Long-term remission of candidiasis with fermented lingonberry mouth rinse in an adult patient with APECED.
APECED, or autoimmune polyendocrine syndrome type 1 (APS-1), is a disease caused by mutations in the autoimmune regulator (AIRE) gene [1]. The consequent impaired immune responses formation of organ-specific autoantibodies (AABs). Disorder manifestations are broad, including organ-specific autoimmunity and chronic mucocutaneous candidiasis (CMC) [2]. Patients need lifelong follow-up and hormone replacement therapy. T helper 17 (Th17)-type adaptive immune response is crucial in the mucosal defense against Candida infections [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 20, 2024 Category: Infectious Diseases Authors: Pirjo P ärnänen, Juho Suojanen, Mikael Laine, Timo Sorsa, Annamari Ranki Tags: Case Report Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
Palliating Undifferentiated Encephalopathy in Creutzfeldt-Jakob Disease vs. Autoimmune Encephalitis
1. Utilizing a case based approach, learners will be able to describe the pathophysiology of Creutzfeldt-Jakob Disease (CJD) and autoimmune encephalitis (AE) that predicts the challenges of managing delirium and agitation.2. Learners will be able to recognize the nuances of undifferentiated encephalopathy in order to mitigate potential harms of an indiscriminate approach to neurocognitive palliation with potent dopaminergic antagonists and consider a more sophisticated approach with second generation antipsychotics possessing less dopaminergic antagonism. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christy Meyer, Cayman Martin, Natsu Fukui Source Type: research
Current status of fertility preservation in a Spanish tertiary public hospital: multidisciplinary approach and experience in over 1500 patients
ConclusionsThe increase in FP treatment reflects the implementation of reproductive counselling in oncology programmes. A multidisciplinary approach in a tertiary public hospital allows individualised FP treatment for each patient. In recent years, there has been a change in trend with the introduction of new indications for FP and a change in techniques due to their optimisation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Immunopathogenesis of multiple sclerosis: molecular and cellular mechanisms and new immunotherapeutic approaches
Conclusion: MS remains incurable, but disease-modifying therapies, monoclonal antibodies, and immunomodulatory drugs offer hope for patients. Ongoing research into the immunogenetics and immunoregulatory roles of gut microbiota continues to shed light on potential therapeutic avenues. Understanding the complex interplay between genetic predisposition, environmental factors, and immune dysregulation is critical for developing effective treatments for MS.PMID:38634438 | DOI:10.1080/08923973.2024.2330642 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 18, 2024 Category: Allergy & Immunology Authors: Mansur Aliyu Fatema Tuz Zohora Ayca Ceylan Fariha Hossain Reza Yazdani Gholamreza Azizi Source Type: research
The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases
Crit Rev Microbiol. 2024 Apr 18:1-21. doi: 10.1080/1040841X.2024.2344114. Online ahead of print.ABSTRACTEpstein-Barr Virus (EBV), a dsDNA herpesvirus, is believed to play a significant role in exacerbating and potentially triggering autoimmune and autoinflammatory maladies. Around 90% of the world is infected with the virus, which establishes latency within lymphocytes. EBV is also known to cause infectious mononucleosis, a self-limited flu-like illness, in adolescents. EBV is often reactivated and it employs several mechanisms of evading the host immune system. It has also been implicated in inducing host immune dysfuncti...
Source: Critical Reviews in Microbiology - April 18, 2024 Category: Microbiology Authors: Abdul Hamid Borghol Elio R Bitar Aya Hanna Georges Naim Elias A Rahal Source Type: research
Extracorporeal membrane oxygenation (ECMO) during aplasia: A bridge towards myopericarditis recovery after autologous hematopoietic stem cell transplant for systemic sclerosis and recent Coronarovirus disease (COVID-19) vaccination
This report illustrates, for the first time to our knowledge, that ECMO can be indicated despite aplasia during aHSCT and successfully used as a bridge towards heart function recovery in highly selected and fragile AD patients. We review the factors that may contribute to endothelial and myocardial stunning and acute reversible cardiac failure in SSc and aggravate intrinsic endothelial injury during the aHSCT procedure. These classically include: cyclophosphamide drug toxicity, viral infections and autoimmune activation with disease flair per se. In the COVID-19 pandemic times, acute myocarditis due to recent viral infecti...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Carlotta Cacciatore Mathilde Baudet Estelle Jean Simona Presente Marylou Para Romain Sonneville Dimitri Arangalage Nassim Ait Abdallah Flore Sicre de Fontbrune Pedro Henrique Prata Benjamin Crichi Baptiste Hervier Nathalie Parquet Gilles Soulat Elie Mouss Source Type: research
Phloridzin reduces synovial hyperplasia and inflammation in rheumatoid arthritis rat by modulating mTOR pathway
In conclusion, phlorizin protects inflammation and reduces injury to the synovial tissues in RA, as it reduces autophagy by regulating Akt/PI3K/mTOR pathway.PMID:38636369 | DOI:10.1016/j.intimp.2024.111727 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 18, 2024 Category: Allergy & Immunology Authors: Liuyu Wang Xiangkun Wu Quanhui Wan Yuqiang Yang Chaojie Gao Source Type: research
MicroRNAs targeting TGF- β signaling exacerbate central nervous system autoimmunity by disrupting regulatory T cell development and function
Eur J Immunol. 2024 Apr 18:e2350548. doi: 10.1002/eji.202350548. Online ahead of print.ABSTRACTTransforming growth factor beta (TGF-β) signaling is essential for a balanced immune response by mediating the development and function of regulatory T cells (Tregs) and suppressing autoreactive T cells. Disruption of this balance can result in autoimmune diseases, including multiple sclerosis (MS). MicroRNAs (miRNAs) targeting TGF-β signaling have been shown to be upregulated in naïve CD4 T cells in MS patients, resulting in a limited in vitro generation of human Tregs. Utilizing the murine model experimental autoimmune encep...
Source: European Journal of Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Christina N Rau Mary E Severin Priscilla W Lee Joshua L Deffenbaugh Yue Liu Shawn P Murphy Cora L Petersen-Cherubini Amy E Lovett-Racke Source Type: research
Sudden unexpected death in a middle-aged woman
Clinical presentation The patient was a woman in her 50s with a history of migraine and Raynaud’s disease. She had episodes of severe migraine that only partially responded to triptans, and worsened during pregnancy approximately 14 years prior, and also during the perimenopausal period approximately 2 years ago. After menopause, her migraines improved, occurred once a month, and responded well to triptans. She had elevated cholesterol. She had no known history of hypertension, diabetes mellitus, coronary artery disease, myocardial infarction, stroke, autoimmune disease or connective tissue disease. She was not on ho...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Casimero, F. V. C., Patalas, E. D., Stone, J. R. Tags: Grand rounds Source Type: research
IL-12/IL-23 independent function of Batf3-dependent dendritic cells is required for initiation of disease in a mouse model of vitiligo
Vitiligo is an IFN- ɣ-dependent autoimmune skin disease that causes depigmentation, and we used a mouse model of vitiligo to investigate the role of the Batf3 transcription factor in disease. Batf3 is required for the survival of a small subset of dendritic cells (DCs) known as type 1 classical DCs (cDC1) (identifiabl e in mice by CD103 and CD8a expression), which are primarily found within epithelial tissues and associated lymph nodes where they provide crucial contributions to pathogen defense, tumor surveillance, and peripheral inflammation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Michael L. Frisoli, Jillian M. Richmond, John E. Harris Tags: Letters to the Editor Source Type: research
Association of CIITA (rs8048002) and CLEC2D (rs2114870) gene variants and type 1 diabetes mellitus
ConclusionThe rare C allele of CIITA rs8048002 genetic variant was associated with an increased risk of developing T1DM, while the less common A allele of CLEC2D rs2114870 was associated with a reduced risk of T1DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Safety of Obinutuzumab in children with autoimmune encephalitis and early B cell repopulation on rituximab.
The study objective was to report the use and safety of obinutuzumab in rituximab-resistant children with neurological inflammatory diseases. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 18, 2024 Category: Neurology Authors: A.T. Nguyen, C. Cotteret, C. Gins, E. Sarda, C. Durrleman, B. Mesples, J. Bustamante, C. Fayard, S. Cisternino, I. Desguerre, M. Aubart Tags: Research Paper Source Type: research
Clinical features, cerebrospinal fluid changes, and prognosis in Chinese patients with autoimmune encephalitis
ConclusionThere are differences in age, gender, clinical characteristics, and CSF results in different subtypes of AE. First-line therapy failure would have poor functional recovery, and delayed therapy would increase the risk of relapse. Chloride ion content and white blood cell count in cerebrospinal fluid are positively correlated with the patient's exacerbation and admission to ICU. These indicators have certain clinical value for the prognosis of AE patients. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 18, 2024 Category: Neurology Source Type: research
Prevalence of autoimmune thyroiditis among children with autoimmune hepatitis
Autoimmune hepatitis (AIH) is an organ specific autoimmune disease, which can manifest at any age of life. there is a high prevalence of extrahepatic autoimmune diseases in patients with AIH. Autoimmune thyroi... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 18, 2024 Category: Pediatrics Authors: Engy Adel Mogahed, Hend M. Soliman, Dalia Saber Morgan, Hoda Mohammed Abd Elaal, Rasha Abd El Razek Mahmoud Khattab, Ragaey A. Eid and Mahmoud Hodeib Tags: Research Source Type: research
