Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
GSE248626 Double-negative T cells ameliorate psoriasis by selectively inhibition on IL-17A producing γδ T cells
In this study, we aimed to evaluate the protection of DNT cells and explore its underlying mechanism. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
In conclusion, our data show that, lowC4A copy number and higher insertion ofHERV-K inC4A increases the risk for SLE.C4 andC4-HERV CNs did not correlate with serum complements, autoantibodies, disease phenotypes and activity in SLE. Further validation in a larger homogenous SLE cohort is needed. (Source: Immunologic Research)
Source: Immunologic Research - April 10, 2024 Category: Allergy & Immunology Source Type: research
Unlocking the Potential of Extracellular Vesicles as the Next Generation Therapy: Challenges and Opportunities
Conclusion:From this perspective, this review delves into the advantages and challenges associated with employing MSC –EVs in clinical settings, with a specific focus on their potential in treating conditions like lung diseases, cancer, and autoimmune disorders. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - April 10, 2024 Category: Biotechnology Source Type: research
Personalized treatment concepts in extraocular cancer
CONCLUSIONS: The optimal treatment for periocular skin cancer depends on the type and size of the tumor and whether it involves orbital and adnexal structures. Adjuvant and neoadjuvant therapy with chemotherapy-targeted therapies and immune checkpoint inhibitors should be considered based on tumor type, tumor molecular profile, expected response rate, and candidacy for systemic treatment.PMID:38590555 | PMC:PMC10999489 | DOI:10.1016/j.aopr.2024.02.003 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Sitong Ju Alexander C Rokohl Yongwei Guo Ke Yao Wanlin Fan Ludwig M Heindl Source Type: research
