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Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting
Int J Mol Sci. 2024 Apr 3;25(7):3983. doi: 10.3390/ijms25073983.ABSTRACTNeutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial proteins, are released by neutrophils in response to pathogens but are also recognized for their involvement in a range of pathological processes, including autoimmune diseases, cancer, and cardiovascular diseases. This review explores the intricate roles of NETs in different cardiovascular conditions such as thrombosis, atherosclerosis, myocardial infarction, COVID-19, and particularly in the pathogenesis of abdominal aortic aneurysms. We elucidate the mechanisms under...
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nahla Ibrahim Wolf Eilenberg Christoph Neumayer Christine Brostjan Source Type: research

Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research

Dawn of CAR-T cell therapy in autoimmune diseases
Chin Med J (Engl). 2024 Apr 12. doi: 10.1097/CM9.0000000000003111. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in the treatment of hematological malignancies. Based on the immunomodulatory capability of CAR-T cells, efforts have turned toward exploring their potential in treating autoimmune diseases. Bibliometric analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases, covering a range of subtypes such as systemic lupus erythema...
Source: Chinese Medical Journal - April 13, 2024 Category: General Medicine Authors: Yuxin Liu Minghao Dong Yunhui Chu Luoqi Zhou Yunfan You Xiaowei Pang Sheng Yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang Chuan Qin Daishi Tian Source Type: research

A Case Report of Autoimmune Encephalitis after Anti-SARS-CoV-2 Vaccination: The Role of Cognitive Impairments in the Diagnostic Process
CONCLUSIONS: In this case, a combination of neuroimaging testing, psychiatric evaluation, and neuropsychological assessment provided evidence for a diagnosis of autoimmune encephalitis post-vaccination. Early recognition is essential in order to prevent clinical progression; avoid intractable epilepsy, brain atrophy, and cognitive impairment; and improve prognosis.PMID:38614963 | DOI:10.1093/arclin/acae031 (Source: Archives of Clinical Neuropsychology)
Source: Archives of Clinical Neuropsychology - April 13, 2024 Category: Psychiatry & Psychology Authors: Marialaura Di Tella Ylenia Camassa Nahi Gabriella Paglia Giuliano Carlo Geminiani Source Type: research

Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | PMC:PMC11012611 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research

Whether and when to biopsy coeliac patients: A never-ending story
Coeliac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine, causing mucosal inflammation and variable villous atrophy. It occurs in genetically predisposed subjects following the ingestion of gluten, a protein complex of cereals such as wheat, barley, rye, whose main fractions are prolamins (including gliadin) and gluten [1]. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 13, 2024 Category: Gastroenterology Authors: Salvatore Cucchiara, Beatrice Leter Tags: Editorial Source Type: research

Succinic Acid Ameliorates Concanavalin A-Induced Hepatitis by Altering the Inflammatory Microenvironment and Expression of BCL-2 Family Proteins
This study provides novel insights into the biological functions and therapeutic potential of succinic acid in the treatment of autoimmune liver injury. (Source: Inflammation)
Source: Inflammation - April 13, 2024 Category: Allergy & Immunology Source Type: research