Pigmentation Effect of Rice Bran Extract in Hair Follicle-Like Tissue and Organ Culture Models
CONCLUSION:Our data suggested that RBE promotes melanin biosynthesis. Taken together, this simplein vitro HFLT model system has the potential to provide significant insights into the underlying molecular mechanisms of HF melanogenesis, and hence can be used for controlled evaluation of the efficacy of new materials for melanogenesis. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 11, 2019 Category: Biotechnology Source Type: research

Applications of Computer Modeling and Simulation in Cartilage Tissue Engineering
Conclusion:Future studies may adopt similar approaches to supplementin vitro trials and further investigate effects of mechanical stimulation on chondrocyte and stem cell dynamics. Additionally, as precision medicine, machine learning, and powerful open-source software become more popular and accessible, applications of multi-scale and multiphysics computational models in cartilage tissue engineering are expected to increase. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 5, 2019 Category: Biotechnology Source Type: research

Updates in molecular imaging techniques
(Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2019 Category: Biotechnology Source Type: research

Multimodal Composite Iron Oxide Nanoparticles for Biomedical Applications
Conclusion:CIONP-based nanoparticles are known for theranostic application, longstanding effects of composite NPs inin vivo systems should also be studied. Once such issues are fixed, multifunctional CIONP-based applications can be extended for theranostics of diverse medical diseases in the future. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2019 Category: Biotechnology Source Type: research

Bladder Augmentation Using Lyoplant ® : First Experimental Results in Rats
Conclusion:In summary, Lyoplant® appears to be a promising tool in experimental bladder augmentation/regeneration in rats. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 26, 2019 Category: Biotechnology Source Type: research

Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine
Conclusion:NIR fluorescence imaging techniques combined with targeted contrast agents can play a significant role in regenerative medicine by monitoring the therapeutic efficacy of implanted cells and scaffolds which would enhance the development of cell therapies and promote their successful clinical translations. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 24, 2019 Category: Biotechnology Source Type: research

Biomaterials for the Treatment of Tendon Injury
Conclusion:Although current biomaterial-based treatment strategies have shown their potential for tendon healing, future research and clinical applications should focused on finding the optimum combinations of regenerative factors with ideal biomaterials for the repair of tendons. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 13, 2019 Category: Biotechnology Source Type: research

Three-Dimensional Spheroid Formation of Cryopreserved Human Dental Follicle-Derived Stem Cells Enhances Pluripotency and Osteogenic Induction Properties
Conclusion:To the best of our knowledge, this is the first study to demonstrate the application of a spheroid culture system for dental follicle-derived stem cells using a microchip dish. Although further studies are needed, includingin vivo transplantation, the results obtained in this study indicate that spheroid hDFSCs derived from cryopreserved dental follicle tissues could be used as a valuable source of autologous stem cells for bone tissue regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 12, 2019 Category: Biotechnology Source Type: research

An Important Role of Macrophages for Wound Margin Regeneration in a Murine Flap Model
Conclusion:Macrophages play a critical role in the flap wound regeneration. Especially, epithelial remodeling at the flap margin is dependent on proper macrophage infiltration. These results implicate to support the cellular mechanisms of impaired flap wound healing. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 12, 2019 Category: Biotechnology Source Type: research

Wound Healing Potential of Low Temperature Plasma in Human Primary Epidermal Keratinocytes
CONCLUSION:Our results suggest that LTP treatment is an effective approach to modulate wound healing-related molecules in epidermal keratinocytes and might promote angiogenesis, leading to improved wound healing. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 4, 2019 Category: Biotechnology Source Type: research

Spreading Shape and Area Regulate the Osteogenesis of Mesenchymal Stem Cells
Conclusion:This study demonstrated that a spreading shape of low circularity and a larger spreading area are beneficial to the survival and osteogenic differentiation of individual MSCs, which may be regulated through the cytosolic expression and distribution of F-actin. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 29, 2019 Category: Biotechnology Source Type: research

In Situ Gelling Hydrogel with Anti-Bacterial Activity and Bone Healing Property for Treatment of Osteomyelitis
Conclusions:From the results, we suggest that thein situ gelling ALG/HA hydrogel containing vancomycin and BMP-2 can be a feasible therapeutic tool to treat osteomyelitis. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 22, 2019 Category: Biotechnology Source Type: research

Near-Infrared Contrast Agents for Bone-Targeted Imaging
Conclusion:By developing bone-targeted NIR contrast agents, optical imaging of bone tissue makes it very attractive for preclinical studies of bone growth or real-time fluorescence guided surgery resulting in high potential to shift the clinical paradigms. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 19, 2019 Category: Biotechnology Source Type: research

Evaluation of Polycaprolactone-Associated Human Nasal Chondrocytes as a Therapeutic Agent for Cartilage Repair
Conclusion:The hNC –PCL complex may be a valuable therapeutic agent for implantation into injured cartilage tissue, and can be used clinically to repair cartilaginous skeletal defects. From a clinical perspective, it is important to set the short duration of the implantation process to achieve effective functional i mplantation. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 19, 2019 Category: Biotechnology Source Type: research

Brown Adipocyte and Splenocyte Co-Culture Maintains Regulatory T Cell Subset in Intermittent Hypobaric Conditions
Conclusion:Both brown and white adipocytes support Treg expression when they are cultured with splenocytes. Of note, brown adipocytes maintained Treg expression in intermittent hypobaric conditions. Anti-inflammatory cytokines and co-inhibitory ligands mediate the immunomodulatory effects of brown adipocytes under altered atmospheric conditions. Brown adipocytes showed the feasibility as a source of adjustment in physical stresses. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 19, 2019 Category: Biotechnology Source Type: research

Updates in Cartilage Tissue Regeneration
(Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 1, 2019 Category: Biotechnology Source Type: research

Updates in Cartilage Tissue Regeneration
(Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 30, 2019 Category: Biotechnology Source Type: research

Development of Macroporous Chitosan Scaffolds for Eyelid Tarsus Tissue Engineering
Conclusions:This bioengineered tissue has the potential to be used as a tarsus substitute during eyelid reconstruction, offering the opportunity to pre-seed the patient ’s own cells and represents a truly personalised approach to tissue engineering. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 26, 2019 Category: Biotechnology Source Type: research

Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodeficiency Mice: Preclinical Study
Conclusion:This study demonstrated that intrathecal injection of hBM-MSCs is safe, non toxic and do not produce tumors. These results provide further evidence that hBM-MSCs might be used in a clinical trial in patients with FRDA. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 26, 2019 Category: Biotechnology Source Type: research

The Interaction between Joint Inflammation and Cartilage Repair
Conclusion:Findings on the role of inflammation in fracture repair and cartilage repair are not in line. The currently widely used models of chondrogenesis, using high differentiation factor concentrations and corticosteroid levels, are not optimal. To make it possible to draw more valid conclusions about the role of inflammation and inflammatory factors on cartilage repair, model systems must be developed that better mimic the real conditions in a joint with damaged cartilage. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 26, 2019 Category: Biotechnology Source Type: research

Stimulatory Effects of KPR-A148 on Osteoblast Differentiation and Bone Regeneration
Conclusion:These results demonstrate that KPR-A148 strongly induces osteoblast differentiation and new bone formation. Therefore, it could be used as a potential therapeutic agent for regenerating bone following its destruction by disease or trauma. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 17, 2019 Category: Biotechnology Source Type: research

Preparation and Characterization of Human Adipose Tissue-Derived Extracellular Matrix, Growth Factors, and Stem Cells: A Concise Review
Conclusion:Depending on the preparation method, the volume, biological activity, and physical properties of ECM, GFs, and adipose tissue-derived cells can vary. Thus, the optimal preparation method is dependent on the intended application of the adipose tissue-derived products. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 5, 2019 Category: Biotechnology Source Type: research

Fabrication of Functional Cell Sheets with Human Thyrocytes from Non-Tumorous Thyroid Tissue
Conclusion:HDM appears suitable as a culture medium for maintaining primary thyrocytes and fabricating functional cell sheets. Thesein vitro findings may contribute to the development of appropriate culture conditions for human thyrocytes as well as engineered functional cell sheets. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 5, 2019 Category: Biotechnology Source Type: research

Current Progress in Tendon and Ligament Tissue Engineering
Conclusions:Tissue engineering showed great promise in replacing the damaged tendon and ligament. However, more study is needed to develop ideal engineered tendon and ligament. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - June 26, 2019 Category: Biotechnology Source Type: research

Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney
Conclusion:In this study, we demonstrated that intermediate mesoderm cells could be induced from ADSCs and that they could differentiate well after cocultured with decellularized scaffolds. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - June 22, 2019 Category: Biotechnology Source Type: research

Bone Morphogenetic Protein 2-Conjugated Silica Particles Enhanced Early Osteogenic Differentiation of Adipose Stem Cells on the Polycaprolactone Scaffold
Conclusion:These results suggest that BCSP composite can be used to promote early stage osteogenic differentiation and show promise as a material for use in scaffolds for bone regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - June 18, 2019 Category: Biotechnology Source Type: research

Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and Angiogenesis In Vitro
Conclusion:A certain concentration of magnesium ions plays an important role in new bone regeneration and reconstruction. It can be used as a simple and effective method to enhance the osteogenesis and angiogenesis of bioceramic scaffolds, and support the development of biomaterials and bone tissue engineering scaffolds. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - June 17, 2019 Category: Biotechnology Source Type: research

Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF- κB Activation
Conclusion:We demonstrated that propofol suppresses the expression of inflammatory substances enhanced by LPS stimulation. Furthermore, this inhibitory effect of propofol on the inflammatory substance expression is mediated by suppression of NF- κB activation. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 29, 2019 Category: Biotechnology Source Type: research

Overview of Urethral Reconstruction by Tissue Engineering: Current Strategies, Clinical Status and Future Direction
CONCLUSION:Hypoxia-preconditioned mesenchymal stem cells in combination with autologous cells seeded on a pre-vascularized synthetic and biodegradable scaffold can be said to be the best combinatory strategy in engineering of human urethra. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 22, 2019 Category: Biotechnology Source Type: research

Modulatory Effects of Single and Complex Vitamins on the In Vitro Growth of Murine Ovarian Follicles
Conclusion:Supplementation of vitamins duringin vitro maturation of murine follicles is an efficient strategy forin vitro expansion of follicular cells. These results could be customized to the sophisticated culture of follicles retrieved from aged or cancer-survived female that contain smaller number of follicles with reduced potential to develop into mature follicles. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 11, 2019 Category: Biotechnology Source Type: research

Generation of Retinal Pigmented Epithelium-Like Cells from Pigmented Spheres Differentiated from Bone Marrow Stromal Cell-Derived Neurospheres
Conclusion:Bone marrow stromal stem cells can differentiate into functional retinal pigmented epithelium cells in a simple, low-cost, high-performance manner over a short period of time. These cells due to expressing the RPELC genes and markers can be used in cell replacement therapy for degenerative diseases including age-related macular degeneration as well as retinitis pigmentosa. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 3, 2019 Category: Biotechnology Source Type: research

Matrix Production in Chondrocytes Transfected with Sex Determining Region Y-Box 9 and Telomerase Reverse Transcriptase Genes: An In Vitro Evaluation from Monolayer Culture to Three-Dimensional Culture
Conclusion:These findings indicated that theSOX9/TERT-transfected chondrocytes incorporation into 3D scaffolds facilitates the cartilage regeneration which is viable structurally and functionally. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 3, 2019 Category: Biotechnology Source Type: research

Repair of Osteochondral Defects in Rabbit Knee Using Menstrual Blood Stem Cells Encapsulated in Fibrin Glue: A Good Stem Cell Candidate for the Treatment of Osteochondral Defects
Conclusion:In summary, MenSCs as unique stem cell population, is suitable forin vivo repair of OCD defects and promising for the future clinical application. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - April 27, 2019 Category: Biotechnology Source Type: research

Exosomes as Therapeutic Vehicles for Cancer
Conclusion:Understanding the molecular and cellular properties of exosomes offer benefits for cancer diagnosis by liquid biopsy and for their application in therapeutic drug delivery systems. Studies have shown that genetic or molecular engineering of exosomes augmented their target specificity and anticancer activity with less toxicity. Thus, deeper understanding of exosome biology will facilitate their therapeutic potential as an innovative drug delivery system for cancer. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - April 23, 2019 Category: Biotechnology Source Type: research

Pentamidine Inhibits Titanium Particle-Induced Osteolysis In Vivo and Receptor Activator of Nuclear Factor- κB Ligand-Mediated Osteoclast Differentiation In Vitro
Conclusion:These results indicate that pentamidine is effective in inhibiting osteoclast formation and significantly attenuates wear debris-induced bone loss in mice. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - April 2, 2019 Category: Biotechnology Source Type: research

Stem Cells Seeded on Multilayered Scaffolds Implanted into an Injured Bladder Rat Model Improves Bladder Function
Conclusion:hADSCs seeded on the multilayered PLCL sheets has the potential to differentiate into SMC, thus facilitating the recovery of compliance and contractility of the injured bladder. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - March 22, 2019 Category: Biotechnology Source Type: research

Preparation and Characterization of Nanocomposite Scaffolds (Collagen/ β-TCP/SrO) for Bone Tissue Engineering
Conclusion:In summary, it was found that the incorporation of Sr into the collagen- β-TCP scaffolds has a great potential for bone tissue engineering applications. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - March 21, 2019 Category: Biotechnology Source Type: research

Histological Method to Study the Effect of Shear Stress on Cell Proliferation and Tissue Morphology in a Bioreactor
Conclusion:We anticipate that our results will help the development and calibration of predictive models, which rely on estimates and morphological description of cell proliferation under shear stress. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - March 21, 2019 Category: Biotechnology Source Type: research

Differentiation Capacity of Monocyte-Derived Multipotential Cells on Nanocomposite Poly(e-caprolactone)-Based Thin Films
Conclusion:To conclude, the differentiation of MOMCs was selectively guided by incorporating SiO2ntbs or SrHAnrds into a polymeric matrix, for the first time.Graphical Abstract (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - March 18, 2019 Category: Biotechnology Source Type: research

Treatment of Periodontal Bone Defects with Stem Cells from Inflammatory Dental Pulp Tissues in Miniature Swine
Conclusion:Autologous DPSCs-IPs may be a feasible means of periodontal regeneration in miniature pigs. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - March 11, 2019 Category: Biotechnology Source Type: research

Characterization of Tendon-Specific Markers in Various Human Tissues, Tenocytes and Mesenchymal Stem Cells
Conclusion:This study demonstrated that 6 commonly used tendon-specific markers were mainly expressed in tendon tissue, but that expression level and pattern of the tendon-specific markers with respect to kinds of tissues, culture duration of tenocytes and sources of MSCs. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - March 4, 2019 Category: Biotechnology Source Type: research

Stem Cell-Based Therapies for Liver Diseases: An Overview and Update
CONCLUSION:Stem cell-based therapy could be a promising therapeutic method for patients with end-stage liver disease, which may alleviate the need for liver transplantation in the future. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - February 21, 2019 Category: Biotechnology Source Type: research

Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine
Conclusions:In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - February 21, 2019 Category: Biotechnology Source Type: research

Conditioned Medium Enhances Osteogenic Differentiation of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
Conclusion:In summary, this study has shown that osteoblast-derived CM can dramatically enhance osteogenic differentiation of iPSC-MSCs toward osteoblasts. Results from this work will contribute  to optimize the osteogenic induction conditions of iPSC-MSCs and will assist in the potential application of iPSC-MSCs for bone tissue engineering. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 29, 2019 Category: Biotechnology Source Type: research

Tissue Regeneration of Human Mesenchymal Stem Cells on Porous Gelatin Micro-Carriers by Long-Term Dynamic In Vitro Culture
Conclusion:The experimental results demonstrated the effect and importance of both micro-carriers and bioreactor in hMSC expansion on cell proliferation and migration as well as extracellular matrix formation on the superficial and pore surfaces of the porous gelatin micro-carriers, and then their inter-connections, leading to tissue regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 28, 2019 Category: Biotechnology Source Type: research

Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment
Conclusions:Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 23, 2019 Category: Biotechnology Source Type: research

Correction to: The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages
Unfortunately, the online published article has error in Figure  3. The name of protein, “Gelectin-1” should be corrected to “Galectin-3”. The corrected Fig. 3 is placed in the following page. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 12, 2019 Category: Biotechnology Source Type: research

Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
CONCLUSION:With recent advances in the development of genome editing technologies such as the CRISPR-Cas9 system, these genetic and epigenetic alternations in OA can be used as platforms from which potential biomarkers for the diagnosis, prognosis, drug response, and development of potential personalized therapeutic targets for OA can be approached. Furthermore, genome editing has allowed the development of “designer” cells, whereby the receptors, gene regulatory networks, or transgenes can be modified as a basis for new cell-based therapies. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 5, 2019 Category: Biotechnology Source Type: research

D-RADA16-RGD-Reinforced Nano-Hydroxyapatite/Polyamide 66 Ternary Biomaterial for Bone Formation
CONCLUSION:This study demonstrates that our nHA/PA66/D-RADA16-RGD composite exhibits reasonable mechanical properties, biocompatibility and bioactivity with promotion of bone formation. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 5, 2019 Category: Biotechnology Source Type: research

Titanium Powder Coating Using Metal 3D Printing: A Novel Coating Technology for Cobalt –Chromium Alloy Implants
AbstractBackground:Three-dimensional (3D) printing with a direct metal fabrication (DMF) technology has been innovatively introduced in the field of surface treatment of prostheses. The purpose of this study was to determine whether such modifications on the surface of cobalt –chromium (CoCr) alloy by titanium powder coating using DMF improves the osseointegration ability of CoCr alloy.Methods:We compared the in vitro and in vivo ability of cells to adhere to DMF-coated CoCr alloy with machining. Biological and morphological responses to human osteoblast cell lines were examined by measuring cell proliferation rate a...
Source: Tissue Engineering and Regenerative Medicine - January 4, 2019 Category: Biotechnology Source Type: research