Conditioned Medium from Tonsil-Derived Mesenchymal Stem Cells Relieves CCl 4 -Induced Liver Fibrosis in Mice
Conclusions:Taken together, these data support the therapeutic potential of T-MSC CM and/or IL-1Ra for the alleviation of liver fibrosis, as well as in treating diseases involving organ fibrosis. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 19, 2018 Category: Biotechnology Source Type: research

In Vivo Safety and Regeneration of Long-Term Transported Amniotic Fluid Stem Cells for Renal Regeneration
Conclusion:This study demonstrates that long-term transported cells under optimized conditions can be used for cell therapy without adverse effects on stem cell characteristics,in vivo safety, and tissue regeneration potency. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 11, 2018 Category: Biotechnology Source Type: research

Biopolymeric In Situ Hydrogels for Tissue Engineering and Bioimaging Applications
Conclusion:The applications of bioactive injectable hydrogels and their bioimaging are a promising area in tissue engineering and regenerative medicine. There is a high demand for injectable hydrogels forin situ imaging. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Hydroxyapatite Nanorod-Modified Sand Blasted Titanium Disk for Endosseous Dental Implant Applications
Conclusions:The modification of Ti implants byl-glutamic acid grafted nHA has produced highly osteogenic Ti disk plants in comparison to pristine Ti disk implants due to the formation of bioactive surfaces by hydroxyapatite nano rods on Ti disk implants. Ti-nHA disk implants showed enhanced adhesion, proliferation, and MC3T3-E1 cells viability in comparison to pristine Ti disk implants. Thus nHA might be to be useful to enhance the osseointegration of Ti implants with teeth bones. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Combination of Mesenchymal Stem Cells, Cartilage Pellet and Bioscaffold Supported Cartilage Regeneration of a Full Thickness Articular Surface Defect in Rabbits
CONCLUSION:HyalofastTM together with BM-MSCs and CP led to efficient cartilage regeneration following full thickness surgical ablation of tibial articular cartilagein vivo in rabbits. Presence of hyaluronic acid in the scaffold and native microenvironment cues probably facilitated differentiation and integration of BM-MSCs. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts
Conclusion:FN-immobilized microgrooved Ti can act as an effective surface for enhancing fibroblast proliferation, and can be used for promoting soft tissue response on the connective tissue attachment zone of biomaterial surfaces. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status
Conclusions:The usage of injectable biomaterials has been increasing for the tissue restoration and regeneration. The future of incorporating ADSCs and growth factors into the injectable biomaterials is promising. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine
Conclusion:In this review, we discuss the use of in situ cross-linkable hydrogels in tissue engineering and regenerative medicine applications. In particular, we focus on emerging technologies as a powerful therapeutic tool for tissue regenerative medicine applications. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Polypeptide Thermogels as Three-Dimensional Scaffolds for Cells
Conclusion:In addition to all the advantages of thermogels including mild conditions for cell-incorporation and controlled supplies of the growth factors, polypeptide thermogels provide neutral pH environments to the cells during the degradation of the gel. Polypeptide thermogels as an injectable scaffold can be a promising system for their eventualin vivo applications in stem cell therapy. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications
Conclusion:Interestingly, the emergence of click chemistry reactions in bioink synthesis for 3D bioprinting have shown the massive potential of these reaction methods in creating 3D tissue constructs. However, the limitations and challenges involved in the click chemistry reactions should be analyzed and bettered to be applied to tissue engineering and 3D bioinks. The future scope of these materials is promising, including their applications inin situ 3D bioprinting for tissue or organ regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Full Thickness Skin Expansion ex vivo in a Newly Developed Reactor and Evaluation of Auto-Grafting Efficiency of the Expanded Skin Using Yucatan Pig Model
Conclusions:These findings provided insight on the potential of this expansion system in promoting dermal extracellular matrix synthesisin vitro. Conclusively, this newly developed smart skin bioreactor enabled effective skin expansionex vivo and successful graftingin vivo in a pig model. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Cellular Response of Anodized Titanium Surface by Poly(Lactide-co-Glycolide)/Bone Morphogenic Protein-2
Conclusion:PLG polymers mixed with rhBMP-2 might improve proliferation, differentiation and osteogenic protein formation of cells on the anodized titanium. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Optimal Stem Cell Transporting Conditions to Maintain Cell Viability and Characteristics
CONCLUSION:Our findings can provide a foundation to optimization of conditions for stem cell transport. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Electrostatically Interactive Injectable Hydrogels for Drug Delivery
Conclusion:The review concludes with perspectives on the future of electrostatically interactivein situ-forming hydrogels. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Characterization of Human Fetal Cartilage Progenitor Cells During Long-Term Expansion in a Xeno-Free Medium
CONCLUSION:These results suggest that SFM-XF supports the long-term expansion of hFCPCs without significant phenotypic and chromosomal changes. This study have also shown that hFCPCs can be mass-producedin vitro, proving their commercial value as a novel source for developing cell therapies. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Injectable Hydrogels for Regenerative Medicine
(Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 1, 2018 Category: Biotechnology Source Type: research

Development and Evaluation of Hyaluronic Acid-Based Hybrid Bio-Ink for Tissue Regeneration
Conclusion:We have developed bio-inks that combine biochemical and mechanical cues. Biochemical cues were able to regulate differentiation of cells, and mechanical cues enabled printing structuring. This multi-functional bio-ink can be used for complex tissue engineering and regenerative medicine. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 21, 2018 Category: Biotechnology Source Type: research

Biopolymeric In Situ Hydrogels for Tissue Engineering and Bioimaging Applications
Conclusion:The applications of bioactive injectable hydrogels and their bioimaging are a promising area in tissue engineering and regenerative medicine. There is a high demand for injectable hydrogels forin situ imaging. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 14, 2018 Category: Biotechnology Source Type: research

Injectable Hydrogels for Regenerative Medicine
(Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 11, 2018 Category: Biotechnology Source Type: research

Late Complications of Allogenic Stem Cells Transplantation in Leukaemia
Conclusion:While allogenic stem cell transplantation is an effective cure for leukaemia, the procedure is associated with complications that can have their onset many years after the procedure. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 6, 2018 Category: Biotechnology Source Type: research

Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status
Conclusions:The usage of injectable biomaterials has been increasing for the tissue restoration and regeneration. The future of incorporating ADSCs and growth factors into the injectable biomaterials is promising. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 1, 2018 Category: Biotechnology Source Type: research

Full Thickness Skin Expansion ex vivo in a Newly Developed Reactor and Evaluation of Auto-Grafting Efficiency of the Expanded Skin Using Yucatan Pig Model
Conclusions:These findings provided insight on the potential of this expansion system in promoting dermal extracellular matrix synthesisin vitro. Conclusively, this newly developed smart skin bioreactor enabled effective skin expansionex vivo and successful graftingin vivo in a pig model. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - September 1, 2018 Category: Biotechnology Source Type: research

Glucosamine Hydrochloride and N -Acetylglucosamine Influence the Response of Bovine Chondrocytes to TGF- β3 and IGF in Monolayer and Three-Dimensional Tissue Culture
Conclusion:GlcN ·HCl and GlcNAc increased cell growth and stimulated COL2 synthesis in long-time 3D culture. However, only GlcNAc added to GF improved proteoglycan synthesis. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 30, 2018 Category: Biotechnology Source Type: research

The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages
CONCLUSION:Our study showed that the immunophenotype and expression of immunomodulation-related cytokines of AD-MSCs and BM-MSCs immunomodulation through the passages were not significantly different, even though the gene expressions of both MSCs were different. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 28, 2018 Category: Biotechnology Source Type: research

Proliferation Profile of Uterine Endometrial Stromal Cells during In Vitro Culture with Gonadotropins: Recombinant versus Urinary Follicle Stimulating Hormone
Conclusions:FSH may inhibit the proliferation of murine uterine endometrial stromal cells duringin vitro culture. rFSH may have more significant inhibitory effects on the proliferation of endometrial stromal cells than uFSH. Establishing an optimal endocrine milieu is necessary using more advanced combination of female hormones forin vitro culture of this type of cells. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 28, 2018 Category: Biotechnology Source Type: research

The Effect of Fibronectin-Immobilized Microgrooved Titanium Substrata on Cell Proliferation and Expression of Genes and Proteins in Human Gingival Fibroblasts
Conclusion:FN-immobilized microgrooved Ti can act as an effective surface for enhancing fibroblast proliferation, and can be used for promoting soft tissue response on the connective tissue attachment zone of biomaterial surfaces. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 28, 2018 Category: Biotechnology Source Type: research

The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages
CONCLUSION:Our study showed that the immunophenotype and expression of immunomodulation-related cytokines of AD-MSCs and BM-MSCs immunomodulation through the passages were not significantly different, even though the gene expressions of both MSCs were different. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 28, 2018 Category: Biotechnology Source Type: research

Proliferation Profile of Uterine Endometrial Stromal Cells during In Vitro Culture with Gonadotropins: Recombinant versus Urinary Follicle Stimulating Hormone
Conclusions:FSH may inhibit the proliferation of murine uterine endometrial stromal cells duringin vitro culture. rFSH may have more significant inhibitory effects on the proliferation of endometrial stromal cells than uFSH. Establishing an optimal endocrine milieu is necessary using more advanced combination of female hormones forin vitro culture of this type of cells. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 28, 2018 Category: Biotechnology Source Type: research

In Situ Cross-Linkable Hydrogels as a Dynamic Matrix for Tissue Regenerative Medicine
Conclusion:In this review, we discuss the use of in situ cross-linkable hydrogels in tissue engineering and regenerative medicine applications. In particular, we focus on emerging technologies as a powerful therapeutic tool for tissue regenerative medicine applications. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 27, 2018 Category: Biotechnology Source Type: research

Hydroxyapatite Nanorod-Modified Sand Blasted Titanium Disk for Endosseous Dental Implant Applications
Conclusions:The modification of Ti implants byl-glutamic acid grafted nHA has produced highly osteogenic Ti disk plants in comparison to pristine Ti disk implants due to the formation of bioactive surfaces by hydroxyapatite nano rods on Ti disk implants. Ti-nHA disk implants showed enhanced adhesion, proliferation, and MC3T3-E1 cells viability in comparison to pristine Ti disk implants. Thus nHA might be to be useful to enhance the osseointegration of Ti implants with teeth bones. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 25, 2018 Category: Biotechnology Source Type: research

Efficient Production of Murine Uterine Damage Model
Conclusion:Taken together, murine uterine damage models were most successfully established by chemical treatment. This production protocols could be applied further to larger animals such as non-human primate. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 18, 2018 Category: Biotechnology Source Type: research

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications
Conclusion:Interestingly, the emergence of click chemistry reactions in bioink synthesis for 3D bioprinting have shown the massive potential of these reaction methods in creating 3D tissue constructs. However, the limitations and challenges involved in the click chemistry reactions should be analyzed and bettered to be applied to tissue engineering and 3D bioinks. The future scope of these materials is promising, including their applications inin situ 3D bioprinting for tissue or organ regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 16, 2018 Category: Biotechnology Source Type: research

Keratinocyte Migration in a Three-Dimensional In Vitro Wound Healing Model Co-Cultured with Fibroblasts
Conclusion:This 3Din vitro wound healing model is a step towards developing a mimetic construct that recapitulates the complex microenvironment of healing wounds and could aid in the early studies of novel therapeutics that promote migration and proliferation of epithelial cells. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 14, 2018 Category: Biotechnology Source Type: research

A Comparison of the Effects of Silica and Hydroxyapatite Nanoparticles on Poly( ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone)/Chitosan Nanofibrous Scaffolds for Bone Tissue Engineering
Conclusion:Compared to other groups, PCEC-CS nanofibers incorporated with 15  wt% n-HA were able to support more cell adhesion and differentiation, thus are better candidates for bone tissue engineering applications. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 14, 2018 Category: Biotechnology Source Type: research

Polypeptide Thermogels as Three-Dimensional Scaffolds for Cells
Conclusion:In addition to all the advantages of thermogels including mild conditions for cell-incorporation and controlled supplies of the growth factors, polypeptide thermogels provide neutral pH environments to the cells during the degradation of the gel. Polypeptide thermogels as an injectable scaffold can be a promising system for their eventualin vivo applications in stem cell therapy. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 14, 2018 Category: Biotechnology Source Type: research

Electrostatically Interactive Injectable Hydrogels for Drug Delivery
Conclusion:The review concludes with perspectives on the future of electrostatically interactivein situ-forming hydrogels. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 9, 2018 Category: Biotechnology Source Type: research

Current Status of Stem Cell Treatment for Type I Diabetes Mellitus
CONCLUSION:Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - August 2, 2018 Category: Biotechnology Source Type: research

Collagen Scaffolds in Cartilage Tissue Engineering and Relevant Approaches for Future Development
Conclusion:Considering the previous improvements of physical and compositional properties of collagen scaffolds and recent manufacturing developments of structural polymer, it is concluded that hybrid strategy is a promising approach to advance further collagen-based scaffolds in CTE. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 25, 2018 Category: Biotechnology Source Type: research

Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity
Conclusion:Therefore, this assay may be powerful tools for determining the efficiency of differentiation systems based on pluripotency. In this study, we not only introduce a new method for determining efficiency based on pluripotency, but also provide more information about the characteristics of osteogenic differentiation which help facilitate future development of more efficient protocols. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 24, 2018 Category: Biotechnology Source Type: research

A 4-Axis Technique for Three-Dimensional Printing of an Artificial Trachea
Conclusion:We suggest that the 4-axis FDM process is more suitable for the development of an accurate and mechanically superior trachea scaffold. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 14, 2018 Category: Biotechnology Source Type: research

Combination of Mesenchymal Stem Cells, Cartilage Pellet and Bioscaffold Supported Cartilage Regeneration of a Full Thickness Articular Surface Defect in Rabbits
CONCLUSION:HyalofastTM together with BM-MSCs and CP led to efficient cartilage regeneration following full thickness surgical ablation of tibial articular cartilagein vivo in rabbits. Presence of hyaluronic acid in the scaffold and native microenvironment cues probably facilitated differentiation and integration of BM-MSCs. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 13, 2018 Category: Biotechnology Source Type: research

Cellular Response of Anodized Titanium Surface by Poly(Lactide-co-Glycolide)/Bone Morphogenic Protein-2
Conclusion:PLG polymers mixed with rhBMP-2 might improve proliferation, differentiation and osteogenic protein formation of cells on the anodized titanium. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 13, 2018 Category: Biotechnology Source Type: research

Wicking Property of Graft Material Enhanced Bone Regeneration in the Ovariectomized Rat Model
AbstractBackground:Recruitment and homing cells into graft materials from host tissue is crucial for bone regeneration.Methods:Highly porous, multi-level structural, hydroxyapatite bone void filler (HA-BVF) have been investigated to restore critical size bone defects. The aim was to investigate a feasibility of bone regeneration of synthetic HA-BVF compared to commercial xenograft (Bio-Oss). HA-BVF of 0.7  mm in average diameter was prepared via template coating method. Groups of animals (n = 6) were divided into two with normal (Sham) or induced osteoporotic conditions (Ovx). Subsequently, subdivided in...
Source: Tissue Engineering and Regenerative Medicine - July 13, 2018 Category: Biotechnology Source Type: research

Three-Dimensional Spheroid Culture Increases Exosome Secretion from Mesenchymal Stem Cells
Conclusion:These results suggested that 3D spheroid culture produces more exosomes than 2D culture and the non-adherent round cell morphology itself might be a causative factor. The result of the present study could provide useful information to develop an optimal process for the mass production of exosomes. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 12, 2018 Category: Biotechnology Source Type: research

Characterization of Human Fetal Cartilage Progenitor Cells During Long-Term Expansion in a Xeno-Free Medium
CONCLUSION:These results suggest that SFM-XF supports the long-term expansion of hFCPCs without significant phenotypic and chromosomal changes. This study have also shown that hFCPCs can be mass-producedin vitro, proving their commercial value as a novel source for developing cell therapies. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 10, 2018 Category: Biotechnology Source Type: research

Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels
CONCLUSION:The strategy of fabricating microchannels in a biomimetic hydrogel and simultaneously providing a chemical cue for angiogenesis is a promising formula for large-scale tissue regeneration. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - July 10, 2018 Category: Biotechnology Source Type: research