Psoriasis is Associated with a High Comedication Burden: A Population Based Register Study
ConclusionPatients with psoriasis have significantly increased numbers of different dispensed prescriptions than those without psoriasis. This underlines previous findings on increased comorbidity and health care costs for patients with psoriasis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 4, 2020 Category: Dermatology Source Type: research

The Correction of Facial Morphea Lesions by Hyaluronic Acid: A Case Series and Literature Review
ConclusionsHA injection and combination of HA application with FAL are minimally invasive, effective and safe therapeutic options for patients suffering from morphea. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 2, 2020 Category: Dermatology Source Type: research

Retrospective Study of Factors Affecting Efficacy of Therapy with Dye Pulsed Light for Erythematotelangiectatic Rosacea
ConclusionDPL is not the optimal procedure for treating severe telangiectasia in patients with ETR, whereas the efficacy of the treatment for erythema was not affected by the severity of the condition. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 31, 2020 Category: Dermatology Source Type: research

Psoriasis Among Adolescents in Kuwait and the Role of Siblings, Breastfeeding, and Household Cat and Secondhand Smoke Exposure: A Cross-Sectional Study
ConclusionsPsoriasis affects a considerable proportion of schoolchildren in Kuwait. Interestingly, psoriasis prevalence was related to risk factors also found in allergic diseases, such as exposure to SHS, cat-keeping in infancy, breastfeeding, and sibship size, possibly suggesting a role of immune dysregulation. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 25, 2020 Category: Dermatology Source Type: research

Development and Content Validation of the Psoriasis Symptoms and Impacts Measure (P-SIM) for Assessment of Plaque Psoriasis
ConclusionsThe P-SIM questionnaire has good content validity; patients reported it was easy to understand and reflective of their experiences. Following psychometric validation, the P-SIM may be a useful PRO measure for capturing the signs, symptoms and impacts of psoriasis and may support clinician-reported outcomes when assessing treatment benefits in clinical trials. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 25, 2020 Category: Dermatology Source Type: research

Cicatricial Alopecia Related to Folliculotropic Mycosis Fungoides
AbstractFolliculotropic mycosis fungoides (FMF) is a particular subtype of mycosis fungoides (MF), characterized by an infiltration of neoplastic CD4+  T cells in the epidermis which can spread to all follicular structures, sebaceous glands, sweat glands and hair follicles. Clinically, FMF can exhibit various cutaneous symptoms. However, these symptoms often occur on the scalp, face and neck, which are rarely affected by conventional MF. We repo rt cicatricial alopecia in a patient with FMF as alopecia lymphomatica. This peculiar symptom should be kept in mind as a critical differential diagnosis of scarring alopeci...
Source: Dermatology and Therapy - August 24, 2020 Category: Dermatology Source Type: research

A Real-World Evaluation of the Long-Term Safety and Efficacy of Infliximab in the Treatment Moderate-to-Severe Psoriasis
ConclusionSurprisingly, patients who are overweight or obese are more likely to obtain long-term clinical benefit in their psoriasis symptoms with infliximab therapy than patients who are normal weight. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 20, 2020 Category: Dermatology Source Type: research

Is Clear Always Clear? Comparison of Psoriasis Area and Severity Index (PASI) and the Physician ’s Global Assessment (PGA) in Psoriasis Clearance
ConclusionsThe use of both PASI and PGA as equivalent assessment tools for complete clearance is redundant and subject to high variability. Novel severity assessments should be developed that reduce calculation variation and take into account patient-oriented symptoms. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 17, 2020 Category: Dermatology Source Type: research

Calcipotriol/Betamethasone Dipropionate Cutaneous Foam Treatment for Psoriasis in Patients With BSA 5 –15% and PGA ≥ 3: Post-Hoc Analysis From Three Randomized Controlled Trials
ConclusionThe results from three clinical trials analyzed together show that topical Cal/BD foam is well tolerated and efficacious for treating patients with moderate-to-severe disease. Data support Cal/BD foam as a potential topical therapy for moderate-to-severe psoriasis.Trial registrationsClinicalTrials.gov registration numbers: NCT01866163, NCT02132936, NCT01536886. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 12, 2020 Category: Dermatology Source Type: research

Association of Alopecia Areata with Vitamin  D and Calcium Levels: A Systematic Review and Meta-analysis
AbstractIntroductionTo investigate the associations of alopecia areata (AA) with serum vitamin  D and calcium levels.MethodsA systematic review of all relevant articles published up to February 2020 in PubMed, Embase, and Cochrane Library databases was conducted. Primary endpoints were serum 25-hydroxyvitamin  D [25(OH)D] levels and vitamin D deficiency, and the secondary endpoint was serum calcium level. Odds ratio (OR) and standardized mean difference (SMD) with 95% CI across studies were analyzed.ResultsData on 1585 patients with AA and 1114 controls from 16 case –control studies and three cross-sec...
Source: Dermatology and Therapy - August 9, 2020 Category: Dermatology Source Type: research

Association Between Patient- and Physician-Reported Outcomes in Patients with Moderate-To-Severe Plaque Psoriasis Treated with Biologics in Real Life (PSO-BIO-REAL)
ConclusionThis study demonstrates that in a real-world setting patients ’ QoL improves with skin clearance. The results also demonstrate that the correlation between skin clearance and improvements in HRQoL (DLQI) and psoriasis symptoms (PSI) is not complete, which highlights the importance of considering both patient- and physician-reported outcomes in the assessment of psoriasis treatment outcomes. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 6, 2020 Category: Dermatology Source Type: research

Dermoscopic and Clinical Response Predictor Factors in Nonsegmental Vitiligo Treated with Narrowband Ultraviolet B Phototherapy: A Prospective Observational Study
ConclusionsTherapeutic response of vitiligo to Nb-UVB phototherapy may be positively affected by local features of the lesions, i.e., face localization and presence of perifollicular pigmentation on baseline dermoscopic examination, which might be considered as positive response predictor factors to optimize treatment of vitiligo. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 4, 2020 Category: Dermatology Source Type: research

Evaluation of BepanGel Hydrogel Efficacy and Tolerability Using an Abrasive Wound Model in a Within-Person, Single-Center, Randomized, Investigator-Blind Clinical Investigation
This study was designed as a within-person, single-center, randomized, investigator-blind clinical investigation comparing a hydrogel-treated test field with an untreated test field in an abrasive wound model. In 33 subjects, two small superficial wounds were induced on the non-dominant forearms. Wounds were treated with BepanGel and covered with a standard semi-occlusive wound plaster or covered with a plaster alone for 11  consecutive days. Wound healing efficacy, cooling effect, and tolerability of the treatment were assessed over 12 investigational days. During follow-up at day 31, the cosmetic appearance of ...
Source: Dermatology and Therapy - August 2, 2020 Category: Dermatology Source Type: research

Dermoscopy of Cutaneous Graft-Versus-Host-Disease in Patients After Allogeneic Hematopoietic Stem Cell Transplantation
ConclusionThe results of this study suggest that dermoscopy may be a useful tool for diagnosing cutaneous GvHD in allo-HSCT recipients. Combining the clinical picture with dermoscopic features may bring us closer to a faster and easier diagnosis of GvHD. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 16, 2020 Category: Dermatology Source Type: research

An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase  1
ConclusionThe sustained moisturization imparted by the test products reduces the need for frequent emollient application, often requiring 3 –4 applications per day for traditional emollients, and should reduce the high burden of managing dry skin conditions like atopic dermatitis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 15, 2020 Category: Dermatology Source Type: research

An Emollient Containing Aquaphilus dolomiae Extract is Effective in the Management of Xerosis and Pruritus: An International, Real-World Study
AbstractIntroductionXerosis and pruritus are common manifestations of numerous dermatologic and systemic diseases. We evaluated the effectiveness of an emollient containing anAquaphilus dolomiae extract (ADE-G1) for the management of pruritus and xerosis in patients of all age with a range of dermatologic and systemic diseases.MethodsThis open-label, real-world study involved 5910 patients from 33 European, South American, Asian, and North and South African countries, who applied the product for 7  days twice daily to the face and body after the skin had been cleansed and dried. The physician assessed xerosis severity...
Source: Dermatology and Therapy - July 14, 2020 Category: Dermatology Source Type: research

Primary Merkel Cell Carcinoma: A Retrospective Analysis of 31 Cases in Poland
ConclusionsFemale gender, tumor-free resection margins, and local disease were found to be independent prognostic factors in MCC progression. Patients with hematological malignancies, immunosuppression, and those with immune deficiencies should be closely followed up as they are predisposed to develop MCC. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 11, 2020 Category: Dermatology Source Type: research

Hypomyopathic Dermatomyositis with Refractory Dermatitis Treated by Low-dose IL-2
We present a 61-year-old hypomyopathic patient with DM who failed to respond to standard therapy but was successfully treated by low-dose interleukin-2 (IL-2) with no significant side effects. We conclude that low-dose IL-2 is a safe and effective treatment for hypomyopathic DM. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 9, 2020 Category: Dermatology Source Type: research

Clinical Characteristics of 18 Patients with Psoriasis and Multiple Myeloma Identified Through Digital Health Crowdsourcing
AbstractPsoriasis is a skin condition that affects over 100 million people worldwide, while multiple myeloma (MM) accounts for 10% of all hematologic malignancies in the US. There has been limited research on the intersection of psoriasis and MM, and clinicians often face difficult decisions in treating patients diagnosed with both conditions. For instance, the management of psoriasis with systemic immunotherapies in MM patients can be challenging because of concern about immunosuppression and possible worsening of MM. Online crowdsourcing platforms have recently become innovative tools that can actively empower patients i...
Source: Dermatology and Therapy - July 7, 2020 Category: Dermatology Source Type: research

Subject Satisfaction with Trifarotene 50  μg/g Cream in the Treatment of Facial and Truncal Acne Vulgaris: A Case Series
We report a case series of three subjects with moderate facial and truncal acne treated with trifarotene 50 μg/g cream on the face, shoulders, upper back and upper anterior chest for 12 weeks and evaluated by satisfaction questionnaires. This case series illustrating the treat ment of facial and truncal acne with trifarotene 50 μg/g cream, in the form of real-world data, describes high overall satisfaction and excellent tolerability to support the use of this new retinoid molecule in the treatment of acne vulgaris on both the face and trunk. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 4, 2020 Category: Dermatology Source Type: research

Costs and Treatment Patterns Among Patients with Atopic Dermatitis Using Advanced Therapies in the United States: Analysis of a Retrospective Claims Database
AbstractIntroductionFor many, atopic dermatitis (AD) is not adequately controlled with topical regimens. This analysis examined treatment using advanced therapies and associated costs.MethodsThe IQVIA Health Plan Claims data set was analyzed. Patients aged  ≥ 12 years with AD who newly initiated advanced therapy after the availability of dupilumab (March 28, 2017) and had ≥ 6 months continuous enrollment before and after their first advanced therapy claim (index date) were included. Advanced therapies included dupilumab, systemic cortico steroids (SCSs), systemic immunosuppressan...
Source: Dermatology and Therapy - June 30, 2020 Category: Dermatology Source Type: research

Intradermal Micro-Dosing of AbobotulinumtoxinA for Face-Lifting: How Long Does It Last?
ConclusionThe results of this study demonstrate the face-lifting effect of ABO intradermal injection. The results show sustained effects up to 3  months after injection. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 26, 2020 Category: Dermatology Source Type: research

Mepolizumab Therapy for Recalcitrant Eosinophilic Annular Erythema in an Adult: A Case Report and Review of Treatment Options
AbstractEosinophilic annular erythema (EAE) is a rare condition with a chronic relapsing and remitting course, characterized by the presence of annular or polycyclic erythematous and plaque lesions and prominent tissue eosinophilia on histopathology. There is an ongoing discussion on whether EAE is a subset of Wells syndrome (eosinophilic cellulitis) or a separate entity. To date, few cases of EAE have been reported in the literature; of these, about 40 cases were in adults and fewer than ten cases were in children. Given the rarity of this condition, there are no clear recommendations for its management. Systemic corticos...
Source: Dermatology and Therapy - June 23, 2020 Category: Dermatology Source Type: research

Platelet-Rich Plasma and its Use for Cicatricial and Non-Cicatricial Alopecias: A Narrative Review
This article aims to identify the major indications for the application of PRP in the field of hair disorders, including non-cicatricial and cicatricial alopecia. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 17, 2020 Category: Dermatology Source Type: research

Real-World Recurrence Rates and Economic Burden in Patients with Resected Early-Stage Melanoma
ConclusionThe SEER data show that a substantial proportion of adults with early-stage melanoma experience a recurrence within 2  years following resection, resulting in a significant economic burden to the US healthcare system. Dermatologists can distinguish patients with resected early-stage melanoma who are at a high risk for recurrence and consider referrals to medical oncologists for approved adjuvant therapy or enrollm ent in clinical trials after surgical resection to reduce the recurrence of melanoma. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 16, 2020 Category: Dermatology Source Type: research

Intralesional Methotrexate for the Treatment of Advanced Keratinocytic Tumors: A Multi-Center Retrospective Study
AbstractIntroductionKeratinocyte tumors (KT) are frequently observed. Surgery is the treatment gold standard. In some cases, a surgical approach might not be the best option. Radiotherapy (RT) and systemic treatments can frequently cause side effects or be contraindicated. Intralesional methotrexate (MTX) can be a conservative yet effective alternative. We decided to evaluate the effectiveness and safety of intralesional chemotherapy with MTX for the treatment of squamous cell carcinoma (SCC), keratoacanthoma (KA), and basal cell carcinoma (BCC).MethodsAll patients had a histologically confirmed diagnosis of BCC, SCC, or K...
Source: Dermatology and Therapy - June 13, 2020 Category: Dermatology Source Type: research

Brodalumab to the Rescue: Efficacy and Safety of Brodalumab in Patients with Psoriasis and Prior Exposure or Inadequate Response to Biologics
AbstractWhile  biologic therapies for psoriasis are effective for many patients, some patients may lose response, have inadequate control of disease, or develop intolerance to certain biologic agents. It may therefore be beneficial for patients whose psoriasis fails to respond to one biologic to switch to a diff erent biologic therapy, in particular one with a different mechanism of action. However, it remains unclear how prior biologic exposure or lack of response affects the efficacy and safety of subsequent biologics in patients with moderate-to-severe psoriasis. Brodalumab, a fully human anti-interleuki n-17 recep...
Source: Dermatology and Therapy - June 12, 2020 Category: Dermatology Source Type: research

Plaque-Type Psoriasis Treated with Calcipotriene Plus Betamethasone Dipropionate Aerosol Foam: A Prospective Study on Clinical and Dermoscopic Predictor Factors in Response Achievement and Retention
ConclusionClinical response of plaque-type psoriasis to calcipotriol/betamethasone dipropionate spray foam may be adversely affected by the degree of infiltration of lesions at baseline and by legs  localization, and the presence of globular vessels at the baseline dermoscopic assessment is related to poor outcomes. A significant post-treatment relapse rate was observed, and persistence of vascular changes on dermoscopy seems to play a role in promoting disease recurrence. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 12, 2020 Category: Dermatology Source Type: research

Clinical, Dermoscopic and In-Vivo Reflectance Confocal Microscopy Evaluation of a Case of Graham Little-Piccardi-Lassueur Syndrome Successfully Treated with Narrowband-UVB Phototherapy
AbstractGraham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare variant of lichen planopilaris, characterized by a triad of clinical signs including follicular spinous papules on the body area, scarring alopecia of the scalp and non-scarring alopecia of the groin and/or axilla. To date, fewer than 50 cases have been described in the literature. We first report a case of GLPLS investigated with non-invasive techniques such as dermoscopy and in vivo reflectance confocal microscopy (RCM) and successfully treated with narrowband-UVB (NB-UVB) phototherapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 12, 2020 Category: Dermatology Source Type: research

Long-term Safety of Oral Systemic Therapies for Psoriasis: A Comprehensive Review of the Literature
AbstractOral systemic therapies are important treatment options for patients with moderate-to-severe psoriasis, either as monotherapy or in therapy-recalcitrant cases as combination therapy with phototherapy, other oral systemics or biologics. Long-term treatment is needed to maintain sufficient disease control in psoriasis, but continuous use of systemic treatments is limited by adverse events (AEs) and cumulative toxicity risks. The primary aim of this comprehensive literature review was to examine the long-term safety profiles of oral agents commonly used in the treatment of adults with psoriasis. Searches were conducte...
Source: Dermatology and Therapy - June 11, 2020 Category: Dermatology Source Type: research

Itch in Children with Type 1 Diabetes: A Cross-Sectional Study
AbstractIntroductionType 1 diabetes (T1D) is reported to be one of the most common medical conditions in school-age youth and is ranked third in the prevalence of pediatric conditions. Only a few studies have investigated the occurrence of itch in diabetes mellitus, reporting conflicting data. The purpose of this study was to investigate the prevalence of itch in T1D to provide itch characteristics and to explore the potential underlying causes.MethodsThis prospective study evaluated itch among 100 children with T1D. Itch intensity was assessed with the Numerical Rating Scale (NRS) and the 4-Item Itch Questionnaire (4IIQ)....
Source: Dermatology and Therapy - June 8, 2020 Category: Dermatology Source Type: research

The Japanese Experience with Basic Fibroblast Growth Factor in Cutaneous Wound Management and Scar Prevention: A Systematic Review of Clinical and Biological Aspects
ConclusionFurther research, with recognition of the therapeutic value of bFGF in wound and scar management and its clinical applications, is needed to provide additional clinical advantages while improving wound healing and reducing the risk of post-surgical scar formation. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 6, 2020 Category: Dermatology Source Type: research

Penile Angiokeratomas (PEAKERs) Revisited: A Comprehensive Review
AbstractAngiokeratomas are benign vascular lesions. Genital angiokeratomas, also referred to as Fordyce angiokeratomas, usually occur on the scrotum in men and the vulva in women. Penile angiokeratoma (PEAKER) is a subtype of genital angiokeratoma in men; clitoral angiokeratoma (CLANKER) is its embryologic analog in women. The PubMed database was used to search the following words: angiokeratoma, clitoris, genital, peaker, penile, penis, rejuvenation, scrotal, scrotum and vulva. The relevant papers and references cited in those papers that were generated by the search were reviewed. The purpose of this article is to summar...
Source: Dermatology and Therapy - June 6, 2020 Category: Dermatology Source Type: research

Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study
AbstractIntroductionActinic keratosis (AK) is a precancerous skin lesion. Currently, many experts treat actinic keratosis as squamous cell carcinoma in situ. It is well established that exposure of the skin to ultraviolet radiation is a major risk factor for the development of actinic keratosis. Some studies suggest an association between keratinocyte cancers and photosensitizing cardiovascular drugs. The aim of this study was to establish an association between cardiovascular drug use and the presence of AK.MethodsA total of 400 patients were enrolled into the study (200 with AK; 200 healthy persons in the control group)....
Source: Dermatology and Therapy - June 6, 2020 Category: Dermatology Source Type: research

Hidradenitis Suppurativa and Concurrent Psoriasis: Comparison of Epidemiology, Comorbidity Profiles, and Risk Factors
ConclusionsHS patients show a broad spectrum of inflammatory and metabolic syndrome-related comorbidities, with an increased risk by concurrent PsO. Important for clinical practice, the elevated cardiovascular risk of HS patients can be largely attributed to smoking. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - June 4, 2020 Category: Dermatology Source Type: research

Novel Coronavirus Disease (COVID-19) and Biologic Therapy for Psoriasis: Successful Recovery in Two Patients After Infection with Severe Acute Respiratory Syndrome Coronavirus  2 (SARS-CoV-2)
AbstractThe outbreak of the novel coronavirus known as SARS-CoV-2 (severe acute respiratory syndrome coronavirus  2) causing COVID-19 was first reported in late December 2019. Many patients with psoriasis on biologic therapy have asked their medical providers about the effect of biologics on COVID-19. However, it is currently unknown how biologic therapy for psoriasis might impact patients with psoriasis and COVID-19. In this article, we report on the clinical course of two patients on biologic medication for psoriasis who developed COVID-19 and successfully recovered from SARS-CoV-2 infection. Both patients presented...
Source: Dermatology and Therapy - May 29, 2020 Category: Dermatology Source Type: research

Melanoma Screening Days During the Coronavirus Disease 2019 (COVID-19) Pandemic: Strategies to Adopt
AbstractMelanoma is one of the most common cancers, with an increasing incidence worldwide. Disease stage represents the most important prognosis factor; therefore, early diagnosis is essential for melanoma patients ’ survival rates. Following the outbreak in China, the coronavirus disease 2019 (COVID-19) pandemic has spread all over the world and the majority of dermatological visits have been postponed. These measures could cause a delay in melanoma diagnosis and management leading to an increase of morbidi ty, mortality and healthcare costs. Herein we propose an alternative model of skin cancer screening and the o...
Source: Dermatology and Therapy - May 28, 2020 Category: Dermatology Source Type: research

Paradoxical Skin Reaction to Certolizumab, an Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis: Case Report with Literature Review
ConclusionParadoxical skin reactions are an emerging clinical entity that require further research in order to establish risk factors and best personalized treatment. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 23, 2020 Category: Dermatology Source Type: research

Association Between Secondary Botulinum Toxin  A Treatment Failure in Cosmetic Indication and Anti-Complexing Protein Antibody Production
ConclusionsBoT/A-exposed patients may develop antibodies against core botulinum toxin and complexing proteins. Our study is the first to demonstrate that anti-complexing protein antibodies cause BTF. High levels of antibodies against complexing proteins can cause onaA unresponsiveness, although some patients were still incoA-responsive. Our developed ELISA to detect anti-complexing protein antibodies can determine whether onaA-tolerant patients respond to incoA without incoA frontalis testing. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 22, 2020 Category: Dermatology Source Type: research

Toripalimab-Induced Dermatomyositis in a Patient with Metastatic Melanoma
Abstract Toripalimab is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). It has recently been approved as an immune checkpoint inhibitor in second-line therapies in patients with unresectable or metastatic melanoma; however, it may be associated with various immune-related adverse events (irAEs). Here we report a case of toripalimab-induced dermatomyositis in a patient receiving treatment for metastatic melanoma. The symptoms were relieved by discontinuing toripalimab and administering once-daily intravenous methylprednisolone 1  mg/kg. We suggest that this case serves a warning to clinicians ...
Source: Dermatology and Therapy - May 22, 2020 Category: Dermatology Source Type: research

Electrocautery Needling and the 308-nm Excimer Lamp: A Synergistic Combination for the Treatment of Stable Non-segmental Vitiligo
ConclusionElectrocautery needling monotherapy was effective in treating vitiligo, and its efficacy was enhanced when combined with the 308-nm excimer lamp. This combined approach to treat vitiligo is safe and helps increase patient compliance. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 21, 2020 Category: Dermatology Source Type: research

Office-Based Surgical Intervention for Hidradenitis Suppurativa (HS): a Focused Review for Dermatologists
AbstractEasily accessible office-based procedures that require minimal resources may facilitate timely surgical management of hidradenitis suppurativa (HS). This review focuses on excision and unroofing as two surgical HS treatments that can be tailored to the outpatient setting. Fifty-five articles were included in our review, representing 3914 patients. The majority were retrospective studies (58%,n = 32), and the studies reported data both across patients and by number of treated lesions. Recurrence rates for unroofing (14.5%) were found to be half that of excision (30%) across patients (p = ...
Source: Dermatology and Therapy - May 20, 2020 Category: Dermatology Source Type: research

Crisaborole Ointment, 2%, for Treatment of Patients with Mild-to-Moderate Atopic Dermatitis: Systematic Literature Review and Network Meta-Analysis
ConclusionsCrisaborole was shown to be superior to vehicle and pimecrolimus and comparable to tacrolimus, 0.1% or 0.03%, with respect to ISGA 0/1 at 28 –42 days in patients aged ≥ 2 years with mild-to-moderate AD. This evaluation of comparative efficacy of crisaborole further supports use of crisaborole as an effective therapeutic option in this population. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 20, 2020 Category: Dermatology Source Type: research

Management of Paediatric Psoriasis by Paediatricians: A Questionnaire-Based Survey
ConclusionThe certainty of the diagnosis, the use of system therapies and the screening for comorbidity could improve the care of PedPso through targeted training of paediatricians and intensified interdisciplinary cooperation with dermatologist. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 18, 2020 Category: Dermatology Source Type: research

Correction to: Treatment of Psoriasis with Secukinumab in Challenging Patient Scenarios: A Review of the Available Evidence
The authors would like to correct the error in Table 1. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 18, 2020 Category: Dermatology Source Type: research

Cutaneous Breast Cancer Metastases Successfully Treated Using an Oxygen Flow Assisted Topical Administration of Methotrexate (OFAMTX)
DiscussionOFAMTX5% represents an alternative skin-directed, painless, patient-friendly and efficacious adjuvant treatment for superficial metastatic lesions of breast cancer. Larger series are required to evaluate the potential of OFAMTX5% for the treatment of superficial metastatic lesions of breast cancer. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 15, 2020 Category: Dermatology Source Type: research

Ixekizumab and Ustekinumab Efficacy in Nail Psoriasis in Patients with Moderate-to-Severe Psoriasis: 52-Week Results from a Phase 3, Head-to-Head Study (IXORA-S)
We present post hoc data from a head-to-head trial of IXE and UST (IXORA-S) to examine the efficacy in nail psoriasis in patients with moderate-to-severe plaque psoriasis over 52  weeks.MethodsIn IXORA-S,  randomised patients received IXE (N = 136) or UST (N = 166) per label for 52 weeks. Eighty-four (61.8%) and 105 (63.3%) of the patients treated with IXE or UST, respectively, had baseline fingernail psoriasis (Nail Psoriasis Severity Index [NAPSI] >  0); of these, 54 (64.3%) and 63 (60.0%) patients, respectively, had significant baseline fingernail psoriasis (...
Source: Dermatology and Therapy - May 15, 2020 Category: Dermatology Source Type: research

Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
We report a 57-year-old man who presented with candidal granuloma caused byCandida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Prolonged duration of initial antifungal therapy did not obtain satisfactory improvement. Finally, the refractory disease was successfully treated by itraconazole and terbinafine in combination with hyperthermia and cryotherapy. The “blackish-red dot” dermoscopic sign of the verrucous granuloma gradually resolved during the treatment. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 14, 2020 Category: Dermatology Source Type: research

A Randomized Controlled Trial with a Medical Device Containing Sodium Hyaluronate and Nicotinic Acid to Increase the Efficacy of Ultraviolet Phototherapy in Psoriasis
ConclusionUV Fotogel is potentially a useful device for enhancement of the efficacy of phototherapy in patients with psoriasis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 9, 2020 Category: Dermatology Source Type: research

Safety and Efficacy of the Sirolimus Gel for TSC Patients With Facial Skin Lesions in a Long-Term, Open-Label, Extension, Uncontrolled Clinical Trial
ConclusionsThe gel was well tolerated for a long time by patients with TSC involving facial skin lesions and continued to be effective.Trial RegistrationClinicalTrials.gov identifier: NCT02634931. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - May 8, 2020 Category: Dermatology Source Type: research