Beyond-Mild Psoriasis: A Consensus Statement on Calcipotriol and Betamethasone Dipropionate Foam for the Topical Treatment of Adult Patients
ConclusionsThese recommendations aim to give practical guidance to those treating patients withbeyond-mild psoriasis, to support patients ’ use of topical preparations and to optimise treatment outcomes. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 12, 2021 Category: Dermatology Source Type: research

Practical Management of Patients with Atopic Dermatitis on Dupilumab
ConclusionThe expert panel provides statements considering the practical management of patients with AD taking dupilumab to inform clinical decision-making in specific but frequently encountered clinical situations. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 11, 2021 Category: Dermatology Source Type: research

Psoriasis and Cardiometabolic Comorbidities: An Evaluation of the Impact of Systemic Treatments in Randomized Clinical Trials
AbstractThe association between psoriasis, metabolic syndrome, and  cardiovascular disease is well established. The shared pathways between psoriasis, metabolic syndrome, and atherosclerosis suggest that treatments targeting the inflammatory pathways of psoriasis may also be beneficial in the treatment of associated cardiometabolic comorbidities. This paper review s the most recent data regarding the impact of systemic psoriasis treatments on comorbid cardiovascular and metabolic disease. Data from randomized clinical trials with systemic and biologic agents are presented. Overall, studies demonstrate benefi...
Source: Dermatology and Therapy - September 10, 2021 Category: Dermatology Source Type: research

Perspectives on the Future Development of Mobile Applications for Dermatology Clinical Research
AbstractThe COVID-19 pandemic significantly impacted clinical research in dermatology and practices around the country transitioned to teledermatology amid physical distancing requirements. Despite their growing use in teledermatology and clinical care, dermatology applications have not been studied extensively in the research space. The use of mobile applications has the potential to improve the experience of study subjects and physicians and increase the pool of individuals willing to participate in research beyond the pandemic. We discuss the various pros and cons of mobile apps, as well as the necessary components they...
Source: Dermatology and Therapy - September 7, 2021 Category: Dermatology Source Type: research

Key Clinical Adverse Events in Patients with Advanced Basal Cell Carcinoma Treated with Sonidegib or Vismodegib: A Post Hoc Analysis
ConclusionThis post hoc analysis suggests lower overall incidence and slower onset of certain AEs in patients treated with sonidegib compared with vismodegib. In the absence of head-to-head comparisons, the relevance of these findings needs further studies to provide conclusive evidence. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 6, 2021 Category: Dermatology Source Type: research

Clinical Features and Risk Factors for Nasal Rosacea: A Hospital-Based Retrospective Study
ConclusionNasal rosacea has relatively specific clinical features and independent risk factors, suggesting that it may be a special type of rosacea. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 4, 2021 Category: Dermatology Source Type: research

Mast Cell Stabilizers in the Treatment of Rosacea: A Review of Existing and Emerging Therapies
AbstractRosacea is a chronic inflammatory skin disease characterized by centrofacial erythema, papules, pustules, and telangiectasias. The onset of rosacea typically occurs after 30  years of age. It is estimated that approximately 2–5% of adults worldwide are affected. While the exact etiology of rosacea remains unknown, its pathogenesis is thought to be multifactorial with both environmental and genetic factors implicated. Ultraviolet radiation, heat, steam, ingested agent s, including spicy foods and alcohol, host vasculature, dermal matrix degeneration, genetic susceptibility, and microbial organisms, includ...
Source: Dermatology and Therapy - September 2, 2021 Category: Dermatology Source Type: research

A Randomized Double-Blind Parallel-Group Study to Evaluate the Long-Term Effects of a Medical Device Containing 0.3% Octatrienoic Acid in the Treatment of Grade III Actinic Keratosis
This study aimed to test the efficacy and tolerability of a medical device containing 2,4,6 -octatrienoic acid and urea for the treatment of hyperkeratotic AK lesions.MethodsSeventy male and female subjects with grade III AK were enrolled in this randomized double-blind parallel-group study. The product was applied once daily for three consecutive months. The primary efficacy endpoint was the reduction in the mean number of AK lesions per subject from baseline (T0) to the end of the trial (T1) and 3  months after the end of the treatment period (T2). Therefore, clearance of target AK lesions at the end of the treatmen...
Source: Dermatology and Therapy - September 2, 2021 Category: Dermatology Source Type: research

Mast Cell Stabilizers in the Treatment of Rosacea: A Review of Existing and Emerging Therapies
AbstractRosacea is a chronic inflammatory skin disease characterized by centrofacial erythema, papules, pustules, and telangiectasias. The onset of rosacea typically occurs after 30  years of age. It is estimated that approximately 2–5% of adults worldwide are affected. While the exact etiology of rosacea remains unknown, its pathogenesis is thought to be multifactorial with both environmental and genetic factors implicated. Ultraviolet radiation, heat, steam, ingested agent s, including spicy foods and alcohol, host vasculature, dermal matrix degeneration, genetic susceptibility, and microbial organisms, includ...
Source: Dermatology and Therapy - September 2, 2021 Category: Dermatology Source Type: research

A Randomized Double-Blind Parallel-Group Study to Evaluate the Long-Term Effects of a Medical Device Containing 0.3% Octatrienoic Acid in the Treatment of Grade III Actinic Keratosis
This study aimed to test the efficacy and tolerability of a medical device containing 2,4,6 -octatrienoic acid and urea for the treatment of hyperkeratotic AK lesions.MethodsSeventy male and female subjects with grade III AK were enrolled in this randomized double-blind parallel-group study. The product was applied once daily for three consecutive months. The primary efficacy endpoint was the reduction in the mean number of AK lesions per subject from baseline (T0) to the end of the trial (T1) and 3  months after the end of the treatment period (T2). Therefore, clearance of target AK lesions at the end of the treatmen...
Source: Dermatology and Therapy - September 2, 2021 Category: Dermatology Source Type: research

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors
ConclusionAt clinically relevant doses and exposures, deucravacitinib demonstrates highly selective inhibition of TYK2 and not JAK 1/2/3. Tofacitinib, upadacitinib, and baricitinib variably inhibit JAK 1/2/3 but not TYK2. These results indicate that deucravacitinib is a distinct class of kinase inhibitor compared with JAK 1/2/3 inhibitors. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 30, 2021 Category: Dermatology Source Type: research

Recognition and Management of Hereditary Angioedema: Best Practices for Dermatologists
AbstractObjectiveThe goal of this article is to discuss the importance of differentiating hereditary angioedema (HAE) from other types of angioedema, describe advances in HAE management, especially long-term prophylaxis (LTP), and offer practical recommendations for dermatologists.CommentaryWhile HAE is rare, dermatologists are likely to encounter patients with this condition at some point over the course of their clinical practice due to the fact that HAE episodes typically involve subcutaneous swelling and sometimes erythema marginatum. HAE is characterized by recurrent episodes of painful and/or disabling bradykinin-med...
Source: Dermatology and Therapy - August 30, 2021 Category: Dermatology Source Type: research

Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24  Months of Follow-Up: Results from US Dermatology Electronic Medical Records
ConclusionsThese real-world findings highlight the high level of sustained satisfaction with secukinumab treatment for improving and maintaining skin clearance in patients with moderate-to-severe disease, regardless of prior treatment experience. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 28, 2021 Category: Dermatology Source Type: research

Efficacy and Safety of Novel Formulation of Clobetasol Propionate 0.025% Cream in Indian Moderate-to-Severe Psoriasis Patients: Phase-2a, Randomized 3-Arm Study
ConclusionClobetasol propionate 0.025% could be an effective treatment for moderate-to-severe psoriasis compared with 0.05% cream, demonstrating comparable efficacy with a better systemic safety profile.Trial Registration NumberREF/2018/01/016779. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 28, 2021 Category: Dermatology Source Type: research

Real-World Satisfaction with Secukinumab in Clearing the Skin of Patients with Plaque Psoriasis through 24  Months of Follow-Up: Results from US Dermatology Electronic Medical Records
ConclusionsThese real-world findings highlight the high level of sustained satisfaction with secukinumab treatment for improving and maintaining skin clearance in patients with moderate-to-severe disease, regardless of prior treatment experience. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 28, 2021 Category: Dermatology Source Type: research

Efficacy and Safety of Novel Formulation of Clobetasol Propionate 0.025% Cream in Indian Moderate-to-Severe Psoriasis Patients: Phase-2a, Randomized 3-Arm Study
ConclusionClobetasol propionate 0.025% could be an effective treatment for moderate-to-severe psoriasis compared with 0.05% cream, demonstrating comparable efficacy with a better systemic safety profile.Trial Registration NumberREF/2018/01/016779. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 28, 2021 Category: Dermatology Source Type: research

The Use of Real-World Data to Evaluate the Association Between Atopic Dermatitis and Cardiovascular Disease: A Retrospective Claims Analysis
ConclusionsAtopic dermatitis may contribute to the risk of developing CVD and MACE in adults, independent of metabolic disorders. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 27, 2021 Category: Dermatology Source Type: research

The Unmet Needs in Atopic Dermatitis Control in Latin America: A Multidisciplinary Expert Perspective
ConclusionThis article includes a narrative analysis of barriers to AD control in LA and provides necessary recommendations to integrate and increase the use of validated AD control assessment tools throughout the region. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 27, 2021 Category: Dermatology Source Type: research

The Use of Real-World Data to Evaluate the Association Between Atopic Dermatitis and Cardiovascular Disease: A Retrospective Claims Analysis
ConclusionsAtopic dermatitis may contribute to the risk of developing CVD and MACE in adults, independent of metabolic disorders. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 27, 2021 Category: Dermatology Source Type: research

Dupilumab Demonstrates Rapid and Consistent Improvement in Extent and Signs of Atopic Dermatitis Across All Anatomical Regions in Pediatric Patients 6  Years of Age and Older
AbstractIntroductionIn phase  III trials in adolescents and children with atopic dermatitis (AD), dupilumab significantly decreased global disease severity. However, the effects of dupilumab on the extent and signs of AD across different anatomical regions were not reported. Here we characterize the efficacy of dupilumab in im proving the extent and signs of AD across four different anatomical regions in children and adolescents.MethodsA post hoc subset analysis was performed using data from two randomized, double-blind, placebo-controlled, international multicenter, phase  III trials of dupilumab therapy in adol...
Source: Dermatology and Therapy - August 24, 2021 Category: Dermatology Source Type: research

Patient Journey in Atopic Dermatitis: The Real-World Scenario
ConclusionsOur analysis revealed a remarkable lack of consensus on various aspects of the routine diagnosis and treatment of AD. These findings suggest the presence of unmet needs or limited implementation of guidelines for the management of AD and encourage further research to explore the causes of this low consensus on the management of AD in the real-world setting. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 23, 2021 Category: Dermatology Source Type: research

Effect of Vitamin-Containing Amino Acid Supplements on Menopausal Symptoms and Age-Related Skin Changes: A Randomised, Double-Blind, Placebo-Controlled Study
ConclusionThese results indicate that the vitamin-containing amino acid supplement improved menopausal symptoms and age-related changes in the skin (wrinkles).Trial RegistrationUMIN000029830. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 22, 2021 Category: Dermatology Source Type: research

Efficacy and Safety Trends with Continuous, Long-Term Crisaborole Use in Patients Aged  ≥ 2 Years with Mild-to-Moderate Atopic Dermatitis
ConclusionThese results support the efficacious and safe continuous, long-term use of crisaborole for the management of mild-to-moderate AD.Trial RegistrationClinicalTrials.gov: NCT02118766, NCT02118792. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 11, 2021 Category: Dermatology Source Type: research

Current Trends of Immunotherapy in the Treatment of Cutaneous Melanoma: A Review
AbstractCutaneous melanoma remains a severe public health threat, with annual incidence increasing slowly but steadily over 4 decades. While early-stage melanomas can typically be treated with complete surgical excision with favorable results, the development of metastatic cancer, which is related to a lower survival rate, is linked to the primary tumor's rising stage and other high-risk features. Even though the first discoveries of an immunological anti-tumor response were published about a century ago, immunotherapy has only been a feasible therapeutic option for cutaneous melanoma in the last 30  years. Nonetheles...
Source: Dermatology and Therapy - August 2, 2021 Category: Dermatology Source Type: research

Long-Term Proactive Treatment of Plaque Psoriasis with Calcipotriene/Betamethasone Dipropionate Foam Prolongs Remission and Reduces Relapses Irrespective of Patient Baseline Characteristics
AbstractIntroductionThe phase 3 PSO LONG study (NCT02899962) demonstrated superior efficacy of proactive (PM) versus reactive management (RM) using calcipotriene 0.005%/betamethasone dipropionate 0.064% (Cal/BD) foam in adults with psoriasis. Here, we evaluated whether certain baseline parameters had an effect on time to first relapse (TTFR), number of relapses, and assessed interactions between treatment effect.MethodsPSO LONG included an initial 4-week open-label phase (once-daily Cal/BD foam) and a 52-week maintenance phase where patients were randomized to twice-weekly Cal/BD (PM) or vehicle foam (RM), with a 4-week on...
Source: Dermatology and Therapy - August 2, 2021 Category: Dermatology Source Type: research

Current Trends of Immunotherapy in the Treatment of Cutaneous Melanoma: A Review
AbstractCutaneous melanoma remains a severe public health threat, with annual incidence increasing slowly but steadily over 4 decades. While early-stage melanomas can typically be treated with complete surgical excision with favorable results, the development of metastatic cancer, which is related to a lower survival rate, is linked to the primary tumor's rising stage and other high-risk features. Even though the first discoveries of an immunological anti-tumor response were published about a century ago, immunotherapy has only been a feasible therapeutic option for cutaneous melanoma in the last 30  years. Nonetheles...
Source: Dermatology and Therapy - August 2, 2021 Category: Dermatology Source Type: research

Can COVID-19 Increase the Risk of Herpes Zoster? A Narrative Review
AbstractHerpes zoster (HZ) is associated with substantial morbidity. It is caused by reactivation of the latent varicella zoster virus (VZV) following decline in cell-mediated immunity, which is commonly age-related, but also occurs in individuals with immunosuppressive diseases and/or treatment. Since coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with T cell immune dysfunction and there have been reports of HZ in COVID-19 patients, we have performed a review of available literature on whether COVID-19 could trigger HZ. We identified 27...
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Construction and Evaluation of a Deep Learning Model for Assessing Acne Vulgaris Using Clinical Images
AbstractIntroductionAccurate assessment is the basis for the effective treatment of acne vulgaris. The goal of this study was to achieve standardised diagnosis and treatment based on a deep learning model that was developed according to the current Chinese Guidelines for the Management of Acne Vulgaris.MethodsThe first step was to divide each image of acne vulgaris into four regions. Each of these four regions of the same patient was then combined to form a complete facial region. The second step was to classify the images based lesion type, in accordance with the current Chinese guidelines, and by treatment strategy adopt...
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

A Qualitative Analysis of Provider Notes of Atopic Dermatitis-Related Visits Using Natural Language Processing Methods
ConclusionThe topics documented in case notes by healthcare providers about their patients with AD focus largely on symptoms and, to a lesser extent, treatment, but do not reflect the burden of AD on patients ’ lives. This finding highlights a potential care gap that warrants further investigation. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Musculoskeletal Imaging for Dermatologists: Techniques in the Diagnosis and Management of Psoriatic Arthritis
AbstractPsoriatic arthritis is an inflammatory condition affecting up to 30% of patients with psoriasis. Patients may experience irreversible joint damage if not treated early, and diagnostic delays of even 6  months are associated with radiographic progression and impaired function. Therefore, early detection and intervention are of critical importance in patients with psoriatic arthritis. Given that psoriasis often precedes symptoms of psoriatic arthritis, dermatologists are uniquely positioned to ide ntify patients with psoriatic arthritis early in their disease course, before permanent damage has occurred. Several...
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

What Do the Lips Say in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation? A Case Series
ConclusionsThe dermoscopic features observed in cGvHD affecting lip vermillion warrant differentiation with inflammatory (lichen planus), autoimmune (lichen sclerosus, discoid lupus erythematosus), precancerous (actinic keratosis, leukoplakia), and neoplastic diseases (squamous cell carcinoma), among others. Dermoscopy of lip vermillion might be an additional tool to visualize diagnostic mucoscopic features of cGvHD (lichen planus-like, lichen sclerosus-like lesions). (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Dupilumab in Adults with Moderate-to-Severe Atopic Dermatitis and Prior Use of Systemic Non-Steroidal Immunosuppressants: Analysis of Four Phase  3 Trials
ConclusionsDupilumab treatment (monotherapy or +  TCS) provides rapid, significant, sustained improvements in signs, symptoms, and quality of life in patients with moderate-to-severe AD compared with control, regardless of prior systemic NSISS use.Clinical Trial RegistrationLIBERTY AD SOLO  1: ClinicalTrials.gov identifier NCT02277743, EudraCT 2014-001198-15. LIBERTY AD SOLO 2: ClinicalTrials.gov identifier NCT02277769, EudraCT 2014-002619-40. LIBERTY AD CHRONOS: ClinicalTrials.gov identifier NCT02260986, EudraCT 2013-003254-24. LIBERTY AD CAFÉ: ClinicalTrials.gov identifier NCT027 55649, EudraCT 20...
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Deterioration of Health-Related Quality of Life After Withdrawal of Risankizumab Treatment in Patients with Moderate-to-Severe Plaque Psoriasis: A Machine Learning Predictive Model
ConclusionsThe predicted DLQI score deteriorated more rapidly after risankizumab withdrawal than the PASI score, an objective measure of disease. These findings suggest that the deterioration in HRQL reflects more substantial impacts after risankizumab discontinuation than those measured by PASI only. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Chlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience
AbstractMycosis fungoides (MF), the most common form of primary cutaneous T-cell lymphoma, is a disease typically with an indolent course that is initially characterized by localized patches and plaques. In the early stages of the disease, treatment involves skin-directed therapies (SDTs) such as topical corticosteroids and retinoids. Chlormethine gel (also known as mechlorethamine) was the first SDT purposely developed to treat MF and is currently endorsed by international guidelines for the treatment of adult patients with MF as a first-line therapy. While chlormethine is an efficacious therapy, its usage may be complica...
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Acne Scarring: Why We Should Act Sooner Rather Than Later
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research

Cutaneous Rosai-Dorfman Disease: A Treatment Challenge
We present the case of a 69-year-old woman with cutaneous RDD presenting as multiple nodules on the right thigh who was treated with low-dose methotrexate weekly for> 1 year with a partial response. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 1, 2021 Category: Dermatology Source Type: research