A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine
We report a case of a 56-year-old man with CBM, identified asFonsecaea pedrosoi infection by fungal culture and gene sequencing. This patient was successfully treated with a regimen of oral itraconazole (ITZ) and terbinafine lasting 7  months. Through in vitro drug sensitivity tests, minimum inhibitory concentrations of amphotericin, ITZ, and terbinafine were 1 μg/ml, 0.25 μg/ml, and 1 μg/ml, respectively. In this case, terbinafine was found to be more effective than ITZ. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 21, 2020 Category: Dermatology Source Type: research

Predictive Value of NUDT15 Variants on Neutropenia Among Han Chinese Patients with Dermatologic Diseases: A Single-Center Observational Study
ConclusionsPretreatment screening of NUDT15 might reduce the chance of azathioprine-induced neutropenia in Han Chinese patients with dermatologic diseases. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 15, 2020 Category: Dermatology Source Type: research

Lichen Planopilaris and Low-Level Light Therapy: Four Case Reports and Review of the Literature About Low-Level Light Therapy and Lichenoid Dermatosis
We report here four patients with LPP who show a dramatic response to LLLT, including a reduction of inflammation, disappearance of symptoms, and evident hair regrowth with no side effects. We review the possible role of LLLT in LPP and other lichenoid conditions. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 14, 2020 Category: Dermatology Source Type: research

Local Management of Anogenital Warts in Non-Immunocompromised Adults: A Network Meta-Analysis of Randomized Controlled Trials
ConclusionsWith low-level evidence of most included RCTs, surgery and electrosurgery were superior to other treatments after clearance and recurrence assessment. Podophyllotoxin 0.5%  was the most efficacious patient-administered treatment. Combined therapies should be evaluated in future RCTs in view of their identified effectiveness. The results of future RCTs should systematically include clinical type, number and location of AGWs, and sex of the patient, to refine therapeut ic indications.Protocol RegistrationPROSPERO-CRD42015025827 (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 6, 2020 Category: Dermatology Source Type: research

Clinical Implications of Primary Cilia in Skin Cancer
AbstractThe primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has sta...
Source: Dermatology and Therapy - January 29, 2020 Category: Dermatology Source Type: research

Correction to: Pathogenesis, Clinical Signs and Treatment Recommendations in Brittle Nails: A Review
Unfortunately, the co-author name was incorrectly published as “Jose L. López-Esterbaranz” instead of ‘Jose L. López-Estebaranz” in the original article. The correct version of author name is updated here.The original article has been corrected. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 22, 2020 Category: Dermatology Source Type: research

Anastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events
AbstractAnastrozole is an aromatase inhibitor. Anastrozole competitively inhibits the aromatase enzyme, which synthesizes estrogen. It is used for estrogen receptor-positive breast cancers. A woman with breast cancer and anastrozole-induced dermatitis is described; the cutaneous side effects associated with aromatase inhibitors are also reviewed. Skin-related adverse events associated with aromatase inhibitor use are uncommon and may be delayed in appearance; the time of onset ranges from less than 5  days to 6 months (median 2 months). They present as either vasculitis, erythema nodosum, subacute cutaneous ...
Source: Dermatology and Therapy - January 21, 2020 Category: Dermatology Source Type: research

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review
AbstractAtopic dermatitis (AD) is a chronic common inflammatory skin disorder with clinical characteristics of pruritic, dry, and recurrent flares that involve the whole body. Recent studies have demonstrated that the skin microbiota, characterized by an overgrowth ofStaphylococcus aureus (S.  aureus), plays a critical role in the manifestation of AD. There is striking evidence that skin microbiota can modulate the development and progression of AD. Therefore, more and more therapeutic approaches are adopted for modifying skin microbiota. Here we discuss the role of skin microbiota in the etiology and maintenance of A...
Source: Dermatology and Therapy - January 20, 2020 Category: Dermatology Source Type: research

Review of Comorbidities of Hidradenitis Suppurativa: Implications for Daily Clinical Practice
AbstractHidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severi...
Source: Dermatology and Therapy - January 18, 2020 Category: Dermatology Source Type: research

The Validity of Cutaneous Body Image as a Construct and as a Mediator of the Relationship Between Cutaneous Disease and Mental Health
AbstractIntroductionCutaneous body image (CBI) is a construct encompassing how individuals perceive their hair, skin, and nails. Negative CBI has been related to negative psychological outcomes and body image concerns. The first aim of our study was to further validate CBI as a construct. Second, as individuals with dermatologic conditions are at an increased risk for anxiety and depression, the study examined CBI as a mediator of the relationships between having a skin condition and anxiety and depression.MethodsA convenience sample of clinical participants with dermatologist-validated diagnoses of psoriasis, atopic derma...
Source: Dermatology and Therapy - January 16, 2020 Category: Dermatology Source Type: research

Trichoscopy of Tinea Capitis: A Systematic Review
ConclusionThe presence of characteristic trichoscopic features of tinea capitis is sufficient to establish the initial diagnosis and introduce treatment before culture results are available. Trichoscopy may be useful in distinguishing betweenMicrosporum andTrichophyton tinea capitis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2020 Category: Dermatology Source Type: research

Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
ConclusionOur results show that some of the histological hallmarks of photoaging are improved with the use of 3-in-1 NFS. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 3, 2020 Category: Dermatology Source Type: research

Systemic Treatment of Psoriasis with JAK Inhibitors: A Review
AbstractPsoriasis is a prevalent chronic inflammatory disease. The inflammatory response is driven by T cells and mediated by multiple cytokines such as tumor necrosis factor and the interleukins IL-17 and IL-23. Moderate-to-severe psoriasis is treated systemically, using either biologics or conventional treatments with small-molecule drugs. The newer biologics are very effective and well tolerated, but not all patients respond to treatment with biologics, so there is a need for new treatment options for psoriasis. Janus kinase (JAK) inhibitors are a new drug class that may be of use in this respect. These inhibitors are a...
Source: Dermatology and Therapy - December 31, 2019 Category: Dermatology Source Type: research

A Comparison of Azathioprine and Mycophenolate Mofetil as Adjuvant Drugs in Patients with Pemphigus: A Retrospective Cohort Study
ConclusionWhile corticosteroid in combination with either AZA or MMF is an effective therapeutic regimen for the treatment of pemphigus, MMF demonstrates a shorter time to achieve CR on therapy and has a significantly higher steroid-sparing effect. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 21, 2019 Category: Dermatology Source Type: research

Prospective Evaluation of the Efficacy of a Food Supplement in Increasing Photoprotection and Improving Selective Markers Related to Skin Photo-Ageing
The objective of this study was to evaluate the efficacy and tolerability of an oral food supplement containing a combination of actives with mainly antioxidative properties (vitamins A, C, D3, E, selenium, lycopene, lutein, as well as green tea, polypodium and grape extracts) in the context of photoprotection.MethodsPhotoprotective efficacy was assessed in a 12-week-long, open, prospective and monocentric clinical study with 30 subjects (27 women and 3 men) having a Fitzpatrick skin type I-III and manifesting clinical ageing signs. The study included several visits (14, 28, 56, and 84  days after starting supplement ...
Source: Dermatology and Therapy - December 4, 2019 Category: Dermatology Source Type: research

Large-Scale Beard Extraction Enhances the Cosmetic Results of Scalp Hair Restoration in Advanced Androgenetic Alopecia in East Asian Men: A Retrospective Study
ConclusionLarge-scale beard extraction, when combined with occipital hair extraction, is a safe and effective treatment to enhance the cosmetic appearance of East Asian men with advanced AGA. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 29, 2019 Category: Dermatology Source Type: research

Safety of Ixekizumab Treatment for up to 5 Years in Adult Patients with Moderate-to-Severe Psoriasis: Results from Greater Than 17,000 Patient-Years of Exposure
ConclusionsThe decrease in rates of TEAEs and the stable rates of SAEs, other malignancies and MACE during up to 5  years of ixekizumab dosing are consistent with previous reports describing a favorable safety profile of ixekizumab following shorter durations of exposure.FundingEli Lilly and Company. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 20, 2019 Category: Dermatology Source Type: research

Clinical and Instrumental Objective Evidence of the Efficacy of a New Water-Based Nail-Strengthening Solution Containing Pistacia lentiscus and Hyaluronic Acid Applied for Up to 6 Months to Improve the Appearance of Weak, Brittle Nails
AbstractIntroductionBrittle nails are fragile or split nails; they affect 20% of the population and may be primary or secondary to different conditions. The aim of our studies was to evaluate the efficacy and tolerability of a new water-based nail-strengthening treatment containing hyaluronic acid andPistacia lentiscus with daily application for a period of 1 –3 months for one study (n = 30) and up to 6 months for a second study (n = 30).MethodsIn total, we enrolled 60 patients of both sexes with brittle and weak nails due to primary or secondary causes and evaluated the efficacy...
Source: Dermatology and Therapy - November 20, 2019 Category: Dermatology Source Type: research

Pathogenesis, Clinical Signs and Treatment Recommendations in Brittle Nails: A Review
AbstractNail plate brittleness (or fragility) is a common complaint affecting up to 20% of the population, especially women over 50  years of age, with fingernail fragility being more prevalent than toenail fragility. Nail brittleness is characterized by nails that split, flake and crumble, become soft and lose elasticity. The main clinical presentations are: onychoschizia, onychorrhexis, superficial granulation of keratin and worn-down nails. According to causative factors, we can distinguish 2 forms of nail fragility (NF): a primary “idiopathic or brittle nail syndrome” form and NF secondary to different...
Source: Dermatology and Therapy - November 20, 2019 Category: Dermatology Source Type: research

Implementation of an Ultraviolet Phototherapy Service at a National Referral Hospital in Western Kenya: Reflections on Challenges and Lessons Learned
ConclusionStrategies that have been helpful in addressing implementation challenges include: increasing on-site and remote training opportunities for clinicians and nurses, developing a tiered payment schema, educating patients to combat misconceptions about phototherapy, dynamic phototherapy referral guidelines to accommodate service delivery capacity, and prioritizing the engagement of a multidisciplinary team. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 16, 2019 Category: Dermatology Source Type: research

Injection Site Reactions in the Federal Adverse Event Reporting System (FAERS) Post-Marketing Database Vary Among Biologics Approved to Treat Moderate-To-Severe Psoriasis
ConclusionsSpecific ISRs varied among the biologic therapies assessed. The findings presented could be helpful when patients consider switching therapies due to ISRs.FundingEli Lilly and Company. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 16, 2019 Category: Dermatology Source Type: research

Exploring Anti-Fungal, Anti-Microbial and Anti-Inflammatory Properties of a Topical Non-Steroidal Barrier Cream in Face and Chest Seborrheic Dermatitis
ConclusionIn conclusion, our assessment is that NSC is an effective and well tolerated treatment option for SD with anti-fungal, anti-microbial and anti-inflammatory properties.Trial RegistrationISRCTN registry, ISRCTN77871064 (retrospectively registered October 17, 2019). EudraCT number, 2019-003813-32.FundingISDIN. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 8, 2019 Category: Dermatology Source Type: research

Acne Vulgaris: A Patient and Physician ’s Experience
AbstractIn this article, the first coauthor, a young woman with acne vulgaris, shares her experience with the condition; she not only describes the clinical presentation and the eventual successful treatment of her acne, but also the emotional consequences that this skin disorder caused. The second coauthor, the patient ’s dermatologist, reviews some of the features of acne vulgaris: morphologic manifestations, pathogenesis, and treatment options. He also summarizes the patient’s response to isotretinoin therapy. In addition, he reveals his subsequent enlightenment regarding the acne-related non-dermatologic ef...
Source: Dermatology and Therapy - November 7, 2019 Category: Dermatology Source Type: research

Incontinentia Pigmenti Associated with Aplasia Cutis Congenita in a Newborn Male with Klinefelter Syndrome: Is the Severity of Neurological Involvement Linked to Skin Manifestations?
We report a rare case of a newborn male affected by incontinentia pigmenti, Klinefelter syndrome, and aplasia cutis congenita, who developed severe cutaneous, neurological, and ophthalmological manifestations. Genetic analysis showed the presence of the common mutation of NEMO (exon 4 –10 deletion), Klinefelter syndrome karyotype (47 XXY), and random X inactivation. This is in accordance with the severity of involvement of the affected tissues (skin, central nervous system, and retina). Indeed, the patient developed typical skin lesions all over the body, except the head. Equal ly, multiple lesions diffusely involvin...
Source: Dermatology and Therapy - November 6, 2019 Category: Dermatology Source Type: research

Rapid Response of Biologic Treatments of Moderate-to-Severe Plaque Psoriasis: A Comprehensive Investigation Using Bayesian and Frequentist Network Meta-analyses
ConclusionsIxekizumab and brodalumab provide the most rapid response and earliest clinical benefit at week 2 among all of the biologics studied, including other biologic treatments such as secukinumab, ustekinumab, guselkumab, adalimumab, and etanercept. BNMA and fNMA results showed similar relative effect estimates and treatment rankings.FundingEli Lilly and Company. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 4, 2019 Category: Dermatology Source Type: research

Epidemiology, Diagnosis, and Treatment of Atopic Dermatitis in the Developing Countries of Asia, Africa, Latin America, and the Middle East: A Review
The objective of this review is to describe the diagnosis, treatment, and management of AD in developing countries in Asia, Africa, Latin America, and the Middle East; to discuss the differences among the countries; and to establish the unmet needs of patients with AD in them. The unmet medical need for treatment of AD in developing countries can be addressed by continuing to train medical specialists, improve access to and affordability of care, and develop new and effective treatments.Funding Pfizer Inc. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 24, 2019 Category: Dermatology Source Type: research

Responder Threshold for Patient-Oriented Eczema Measure (POEM) and Children ’s Dermatology Life Quality Index (CDLQI) in Adolescents with Atopic Dermatitis
AbstractIntroductionThe Patient-Oriented Eczema Measure (POEM) assesses patient-reported frequency of atopic dermatitis (AD) symptoms, while the Children ’s Dermatology Life Quality Index (CDLQI) measures the impact of skin disease on health-related quality of life (HRQoL) in children. There is currently no threshold for clinically meaningful within-person change in POEM or CDLQI scores in adolescents. Here we empirically derive within-person thres holds of meaningful within-person change in POEM and CDLQI scores in adolescents with moderate-to-severe AD.MethodsData were used from a phase 3, randomized, double-blind,...
Source: Dermatology and Therapy - October 22, 2019 Category: Dermatology Source Type: research

Understanding Treatment Preferences in Patients with Moderate to Severe Plaque Psoriasis in the USA: Results from a Cross-Sectional Patient Survey
ConclusionsOverall, in this study with more than 70% of patients with moderate disease, patients reported high burden of disease and impact on QoL. This study demonstrates the importance of considering patient perspectives in treatment decisions that are critical for optimizing patient outcomes.FundingEli Lilly and Company. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 19, 2019 Category: Dermatology Source Type: research

An Open-Label, Intra-Individual Study to Evaluate a Regimen of Three Cosmetic Products Combined with Medical Treatment of Rosacea: Cutaneous Tolerability and Effect on Hydration
AbstractIntroductionAlthough rosacea management includes general skincare, previous studies have not evaluated comprehensive skincare regimens as adjuvants to other treatments.MethodsThe primary objective of this open-label, intra-individual study of subjects with rosacea was to evaluate the cutaneous tolerability of a regimen consisting of Cetaphil PRO Redness Control Day Moisturizing Cream (once daily in the morning), Cetaphil PRO Redness Control Night Repair Cream (once daily in the evening) and Cetaphil PRO Redness Control Facial Wash (foam once in the morning and once in the evening). Secondary objectives were to eval...
Source: Dermatology and Therapy - October 17, 2019 Category: Dermatology Source Type: research

Local Management of Anogenital Warts in Non-immunocompromised Adults: A Systematic Review and Meta-analyses of Randomized Controlled Trials
ConclusionThe vast majority of included RCTs had a low level of evidence, thereby preventing the establishment of a hierarchy of treatments. Nevertheless, our results provide an overview of the main AGW treatments available for general practitioners and specialists. While provider-administered treatments are superior, patient-administered treatments (e.g., imiquimod, podophyllotoxin) are useful solutions for compliant patients.Protocol registrationPROSPERO-CRD42015025827. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 13, 2019 Category: Dermatology Source Type: research

Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata
ConclusionsEvidence on the efficacy and safety of drugs targeting the JAK/STAT pathway for the treatment of patients with AD, vitiligo, or AA is increasing but is still of low quality. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 13, 2019 Category: Dermatology Source Type: research

Use of Topical Nitric –Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population
ConclusionNZCS was an effective treatment of warts in this pediatric population. The painlessness, simplicity, and twice-monthly dosing regimen of this treatment represents an advantage over standard approaches.FundingISDIN.Trial RegistrationRetrospectively registered 6 September 2019, ISRCTN90862249. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 4, 2019 Category: Dermatology Source Type: research

Sex Differences in Keloidogenesis: An Analysis of 1659 Keloid Patients in Japan
ConclusionThis is the first report to suggest that female sex may drive keloidogenesis because of physiological reasons. Individuals were most likely to seek a medical examination almost 10  years after onset, regardless of sex. These findings provide new insight into the importance of sex in the development and progression of keloids. Future studies should address the influence of sex hormones on the keloid. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 4, 2019 Category: Dermatology Source Type: research

Management of Itch in the Elderly: A Review
AbstractChronic itch is common in the elderly patient and may be caused by a variety of known dermatologic and non-dermatologic conditions and can have a significant effect on quality of life. Age-related changes in barrier function, immunosenescence, and neuronal changes and neuropathies are common predisposing factors to chronic itch in this age group. Certain primary dermatologic conditions are more common in the elderly and can cause chronic itch. Also, co-morbid diseases particularly of the renal, hepatobiliary, or hematologic systems, psychologic conditions, or medications may contribute to chronic itch in this popul...
Source: Dermatology and Therapy - September 23, 2019 Category: Dermatology Source Type: research

Antimicrobial Susceptibility, Biotypes and Phylotypes of Clinical Cutibacterium (Formerly Propionibacterium ) acnes Strains Isolated from Acne Patients: An Observational Study
ConclusionErythromycin and clindamycin resistances are the most common in clinicalC. acnes strains; BIII is the predominant biotype and IA1 is the major phylotype ofC. acnes, which are mainly related to disease severity. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 19, 2019 Category: Dermatology Source Type: research

Delusions of Parasitosis: An Update
AbstractDelusional parasitosis, also known as delusional infestation or Ekbom syndrome, is a relatively infrequent psychotic disorder characterized by an unwavering false belief that there is a parasitic infestation of the skin, despite the absence of any medical evidence that could support this claim. Delusional parasitosis can be categorized into primary, secondary, and organic forms. Sometimes, close relatives also experience identical delusions. This phenomenon was reported to occur in 5 –15% of cases, and is known as shared psychotic disorder–delusional parasitosis with folie à deux. Patients with d...
Source: Dermatology and Therapy - September 13, 2019 Category: Dermatology Source Type: research

Review of Scabies in the Elderly
This article aims to describe the susceptibility factors, clinical presentation, diagnosis, and management considerations specific to elderly adults with scabies. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 11, 2019 Category: Dermatology Source Type: research

Erythema of Rosacea Affects Health-Related Quality of Life: Results of a Survey Conducted in Collaboration with the National Rosacea Society
AbstractIntroductionPersistent facial erythema associated with rosacea may negatively impact quality of life (QoL), self-esteem, and self-confidence. We evaluated burden and health-related QoL (HRQoL) impacts of centrofacial erythema of rosacea.MethodsA cross-sectional, Web-based survey conducted in collaboration with the National Rosacea Society enrolled adults who self-reported having received a physician diagnosis of rosacea and self-evaluated their current erythema as mild to severe on the validated Subject Self-Assessment for Rosacea Facial Redness. Sociodemographic and clinical characteristics, rosacea symptoms, and ...
Source: Dermatology and Therapy - September 11, 2019 Category: Dermatology Source Type: research

The Neuromodulatory Effect of Antipruritic Treatment of Chronic Prurigo
AbstractChronic prurigo is an extremely severe pruritic skin disease which presents with multiple, hyperkeratotic and erosive papules, nodules and/or plaques. Patients with this high-burden disease require effective therapies, but effective treatments with regulatory agency approval are currently lacking. Deeper understanding of the pathophysiology suggests that hypersensitive nerves play an important role in the development of chronic prurigo. Accordingly, a treatment with neuroactive substances which modulate hypersensitivity seems promising. Here, we review antipruritic therapies with a neuromodulative effect. Current t...
Source: Dermatology and Therapy - September 11, 2019 Category: Dermatology Source Type: research

Long-Term Efficacy of Vismodegib After its Withdrawal and Patients ’ Health-Related Quality of Life Using the Dermatology Life Quality Index (DLQI)
ConclusionThe results of this exploratory analysis of vismodegib withdrawal are consistent with a substantial link between treatment response and patients ’ HRQoL. Furthermore, 11 out of 35 (31%) patients that reported a complete remission of the disease after 6 months of vismodegib treatment reported BCC recurrence. These data highlight the importance of continuous follow-up and perhaps different regimens of treatment, such as an alternate dose re gimen to maintain disease control and reduce the adverse events as previously described in the literature. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 10, 2019 Category: Dermatology Source Type: research

Fractional Erbium-YAG Laser and Platelet-Rich Plasma as Single or Combined Treatment for Atrophic Acne Scars: A Randomized Clinical Trial
ConclusionsThe combination of platelet-rich plasma plus erbium-YAG laser is superior to either treatment alone for acne scars, with trivial side effects for all treatment modalities.Trial RegistrationClinicalTrials.gov identifier; NCT03933033. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 16, 2019 Category: Dermatology Source Type: research

Revisiting Imiquimod for Treatment of Folliculotropic Mycosis Fungoides: A Case Report and Review of the Literature
We report a 21-year-old patient with unilesional FMF who achieved clinical remission with imiquimod application. This case highlights a potential for use of imiquimod as a treatment option for patients with FMF and limited skin involvement. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 12, 2019 Category: Dermatology Source Type: research

Topical Non-Pharmacological Treatment for Facial Seborrheic Dermatitis
AbstractFacial seborrheic dermatitis (FSD) is a chronic and relapsing inflammatory skin disorder occurring in areas of the face rich in sebaceous glands. It clinically manifests as erythematous scaly macules or plaques, often associated with pruritus. Although the pathogenesis of seborrheic dermatitis is not yet fully understood,Malassezia yeast, hormones, sebum levels, and immune response are known to play important roles. Additional factors including drugs, cold temperatures, and stress may exacerbate the condition. Currently, the available treatments do not cure the disease but relieve symptoms. Various pharmacological ...
Source: Dermatology and Therapy - August 8, 2019 Category: Dermatology Source Type: research

Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial
ConclusionsOnce-daily application of dissolving triamcinolone-embedded microneedles significantly reduced the volume of keloids. The treatment was safe, can be self-administered and can serve as an alternative for patients unsuitable for conventional treatments.Trial RegistrationTrial Registry: Health Science Authority (Singapore) Clinical Trials Register Registration number: 2015/00440. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - August 2, 2019 Category: Dermatology Source Type: research

New Methodology to Evaluate Sunscreens Under Outdoor Conditions: A Double-Blind, Randomized Intra-Individual Clinical Study of a Water-Based Broad-Spectrum SPF50+ Versus SPF15 (P3) and SPF50+
ConclusionThis exploratory study confirmed the ability of this outdoor model to discriminate sunscreens with different SPF using clinical evaluation as an objective measure. The water-based sunscreen maintained its efficacy in outdoor conditions of very high to extreme UV radiation: it was superior to SPF15 and comparable to SPF50+ controls in preventing erythema. The method used represents an option for sunscreen efficacy comparison outside of the laboratory.FundingIsdin. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 27, 2019 Category: Dermatology Source Type: research

Atrophic Dermatofibroma: A Comprehensive Literature Review
ConclusionAn atrophic dermatofibroma is an uncommon benign variant of a dermatofibroma. The diagnosis can be suspected based on clinical features and dermatoscopic findings. A biopsy of the lesion will confirm the diagnosis. Periodic evaluation of the lesion site is a reasonable approach to the management of the residual tumor. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 23, 2019 Category: Dermatology Source Type: research

Genetic Hair Disorders: A Review
AbstractHair loss in early childhood represents a broad differential diagnosis which can be a diagnostic and therapeutic challenge for a physician. It is important to consider the diagnosis of a genetic hair disorder. Genetic hair disorders are a large group of inherited disorders, many of which are rare. Genetic hair abnormalities in children can be an isolated phenomenon or part of genetic syndromes. Hair changes may be a significant finding or even the initial presentation of a syndrome giving a clue to the diagnosis, such as Netherton syndrome and trichothiodystrophy. Detailed history including family history and physi...
Source: Dermatology and Therapy - July 22, 2019 Category: Dermatology Source Type: research

ERAPSO: Revealing the High Burden of Obesity in German Psoriasis Patients
ConclusionERAPSO revealed inadequate medical care of obese psoriasis participants with insufficient support for weight loss through diet or increased physical activity. Although psoriasis participants showed an intact self-perception of obesity, they seemed to lack intrinsic motivation to lose weight, highlighting the need for external support in losing weight via tailored programs. Since psoriasis severity correlates with impairment in diets and sports, treating psoriasis adequately may allow participants to follow weight loss programs more successfully.FundingNovartis Pharma GmbH, Nuremberg, DE. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 11, 2019 Category: Dermatology Source Type: research

Novel Non-Steroidal Facial Cream Demonstrates Antifungal and Anti-Inflammatory Properties in Ex Vivo Model for Seborrheic Dermatitis
AbstractIntroductionSeborrheic dermatitis (SEBD) is a chronic, recurrent skin disorder that typically occurs as an inflammatory response to fungi of the genusMalassezia. The development of an ex vivo model that mimics the fungal proliferation and skin inflammation of SEBD would play an important role in screening formulations for their efficacy in treating SEBD.MethodsAn ex vivo model for SEBD using human skin explants that had been mechanically manipulated to facilitate colonization ofMalassezia furfur was developed. This model was used to evaluate the efficacy of a novel non-steroidal facial cream (NSFC) in inhibitingM. ...
Source: Dermatology and Therapy - July 5, 2019 Category: Dermatology Source Type: research

Remission Duration and Long-Term Outcomes in Patients with Moderate-to-Severe Psoriasis Treated by Biologics or Tofacitinib in Controlled Clinical Trials: A 15-Year Single-Center Experience
ConclusionsSystemic treatment was required in 86.1% of patients within 12  months after biologic withdrawal and biologics were reinitiated in 77.1% of patients after 3 years. However, early biologic administration within 2 years after diagnosis demonstrated a lower risk of relapse in patients with moderate-to-severe psoriasis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 3, 2019 Category: Dermatology Source Type: research