The Potential Benefits of Certolizumab Pegol in Patients with Concurrent Psoriatic Arthritis and Chronic Plaque Psoriasis: A Case Series and Review of the Literature
ConclusionCertolizumab is efficacious in both psoriasis and PsA, including in patients who are biologic failures, and could be considered as an alternative treatment modality. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 16, 2019 Category: Dermatology Source Type: research

Understanding the Burden of Atopic Dermatitis in Africa and the Middle East
AbstractAtopic dermatitis (AD) is a common inflammatory skin disease characterized by intensely pruritic lesions. The prevalence of atopic dermatitis is increasing in developing regions, including Africa and the Middle East. However, these regions are underrepresented in the dermatology literature, and a better understanding of the growing burden of atopic dermatitis in Africa and the Middle East is necessary. Herein, we summarize current knowledge on atopic dermatitis epidemiology, disease burden, and treatment options in Africa and the Middle East, highlighting the unmet needs of patients in these regions. With these nee...
Source: Dermatology and Therapy - March 8, 2019 Category: Dermatology Source Type: research

Correction to: Efficacy and Tolerability of a Medical Device Repairing Emollient Cream Associated with a Topical Corticosteroid in Adults with Atopic Dermatitis: An Open-label, Intra-individual Randomized Controlled Study
The original article can be found online. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 1, 2019 Category: Dermatology Source Type: research

Merkel Cell Carcinoma: Therapeutic Update and Emerging Therapies
AbstractMerkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine skin cancer whose incidence has almost doubled in recent decades. Risk factors for MCC include age> 65  years, immunosuppression, sun exposure and infection by Merkel cell polyomavirus. MCC usually presents as rapidly growing, firm, red to violaceous nodule localized on the sun-exposed skin. Surgery followed by radiation therapy is considered to be the first-line treatment for primary or loco-region al MCC in order to prevent recurrences and lymph node metastasis, while chemotherapy has always been used to treat advanced forms. Howev...
Source: Dermatology and Therapy - February 28, 2019 Category: Dermatology Source Type: research

Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin
ConclusionWe report a case of GEKA associated with the presence of HPV39 and the successful use of acitretin combined with surgical removal of the larger lesions. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 21, 2019 Category: Dermatology Source Type: research

Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience
ConclusionIntralesional methotrexate seems to be an effective and safe nonoperative treatment modality for keratoacanthoma, especially when it arises in anatomic areas difficult to treat with surgery, in elderly debilitated patients, and in those refusing surgery. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 21, 2019 Category: Dermatology Source Type: research

Adverse Events from Emollient Use in Eczema: A Restricted Review of Published Data
AbstractAtopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Medline (Ovid) was searched from inception (1946) to June 2018. All types of studies, with the exception of reviews, were included. Eligibility was assessed using a two-stage screening process against inclusion and exclusion criteria. References of all included pa...
Source: Dermatology and Therapy - February 15, 2019 Category: Dermatology Source Type: research

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - February 15, 2019 Category: Dermatology Source Type: research

Tolerability of Topical Treatments for Atopic Dermatitis
This article also reviews published strategies for managing sensory tolerability issues in AD patients during treatment with topical therapies.Funding: Pfizer Inc., New York, NY. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 24, 2019 Category: Dermatology Source Type: research

New Vision in Photoprotection and Photorepair
AbstractChronic exposure to solar radiation is associated with an increased incidence of skin cancer worldwide and more specifically with non-melanoma skin cancers and actinic keratosis. At the cellular level DNA damage is the main event following ultraviolet (UV) exposure. The kind of lesions produced depends on the wavelength and the energy profile of the radiation, with different photoproducts being formed as a result. Although endogenous DNA repair mechanisms are somewhat effective in repairing DNA, some DNA damage persists and can accumulate with chronic exposure. UV protection strategies, such as sunscreen use, are i...
Source: Dermatology and Therapy - January 23, 2019 Category: Dermatology Source Type: research

Self-Assessments of Standardized Scalp Massages for Androgenic Alopecia: Survey Results
ConclusionsWhile further research is warranted, these results align with previous findings and suggest the potential for SSMs to improve AGA. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 22, 2019 Category: Dermatology Source Type: research

Clinical Goals and Barriers to Effective Psoriasis Care
AbstractEngaging global key opinion leaders, the International Psoriasis Council (IPC) held a day-long roundtable discussion with the primary purpose to discuss the treatment goals of psoriasis patients and worldwide barriers to optimal care. Setting clear expectations might ultimately encourage undertreated psoriasis patients to seek care in an era in which great gains in therapeutic efficacy have been achieved. Here, we discuss the option for early treatment of all categories of psoriasis to alleviate disease impact while emphasizing the need for more focused attention for psoriasis patients with mild and moderate forms ...
Source: Dermatology and Therapy - December 21, 2018 Category: Dermatology Source Type: research

The Role of Vitamins and Minerals in Hair Loss: A Review
AbstractPeople commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing. Management of alopecia is an essential aspect of cl...
Source: Dermatology and Therapy - December 13, 2018 Category: Dermatology Source Type: research

Propionibacterium ( Cutibacterium ) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives
AbstractAcne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit,Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. A delicate balance of these microorganisms is essential for the barrier function of the skin.Propionibacterium acnes represents nearly 90% of the human skin microbiome of healthy adults. Acne is a chronic recurrent disease that requires long-lasting t...
Source: Dermatology and Therapy - December 11, 2018 Category: Dermatology Source Type: research

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence
AbstractBasal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. The introduction of a novel class of drugs, the Hedgehog pathway inhibitors, into clinical practice has ushered in a new treatment algorithm for the treatment of difficult BCC cases. In this review we present the latest available evidence and discus...
Source: Dermatology and Therapy - December 11, 2018 Category: Dermatology Source Type: research

Clinical and Biophysical Outcomes of Combining Microfocused Ultrasound with Visualization and Calcium Hydroxylapatite Filler for Facial Treatment
The objective of this clinical evaluation was to assess the long-term safety and efficacy of combining microfocused ultrasound with visualization (MFU-V) treatment with a calcium hydroxylapatite (CaHA) dermal filler to tighten skin at the submental region and contour the jawline.MethodsWomen with loss of contour and skin laxity in the lower face received MFU-V treatment. If subjects did not respond satisfactorily after 12  weeks, they received CaHA to the jawline. Evaluations—which were performed by blinded raters at baseline and after 12, 24, and 48 weeks—included live Global Aesthetic Improvement Sc...
Source: Dermatology and Therapy - December 8, 2018 Category: Dermatology Source Type: research

Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis
ConclusionsBased on our evaluation of 59 subjects with either erysipelas or bacterial cellulitis, combination therapy with amoxicillin + clavulanic acid appears to be linked with the shortest stay in the hospital. We suggest that this combination therapy should be considered as a first-line treatment for patients hospitalized due to erysipelas or bacterial cellulitis, if other factors did not preclude the use of this therapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 7, 2018 Category: Dermatology Source Type: research

Efficacy and Safety of a Water-Based Head Lice Lotion: A Randomized, Controlled, Investigator-Blinded, Comparative, Bicentric Study
ConclusionAqueous dispersions of silylated polyols are a promising new class of pediculicides that combine high cure rates with optimal user convenience (short treatment period, easy wash-out with positive effect on hair quality).Trial RegistrationClinicalTrials.gov identifier, NCT03617926.FundingOystershell Laboratories. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 30, 2018 Category: Dermatology Source Type: research

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum
In conclusion, men can develop scrotal changes due to either intrinsic (aging) or extrinsic (trauma) causes, but nonsurgical interventions and surgical procedures are available for the management of these conditions in individuals who desire to rejuvenate their scrotum. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 26, 2018 Category: Dermatology Source Type: research

Impact of Ixekizumab Treatment on Itch and Psoriasis Area and Severity Index in Patients with Moderate-to-Severe Plaque Psoriasis: An Integrated Analysis of Two Phase III Randomized Studies
AbstractIntroductionWe evaluated baseline itch and its impact on the efficacy of ixekizumab (IXE) in clearing psoriasis and improving quality-of-life measures, and we explored the relationship between itch and psoriatic skin improvement.MethodsData were analyzed from two double-blind, randomized, controlled phase III studies (UNCOVER-2/3) comparing etanercept (ETN), IXE, and placebo (PBO) in patients with moderate-to-severe plaque psoriasis. Long-term analysis included UNCOVER-3 data from week 0 to week 156.ResultsAt week 12, a clinically meaningful improvement in itch [Itch Numeric Rating Scale (NRS) reduction  &ge...
Source: Dermatology and Therapy - November 21, 2018 Category: Dermatology Source Type: research

Burden of Herpes Zoster in the Japanese Population with Immunocompromised/Chronic Disease Conditions: Results from a Cohort Study Claims Database from 2005 –2014
ConclusionsThe elevated burden of HZ in Japanese individuals harboring IC conditions and chronic disorders documented in our study underlines the need for prevention of HZ in people with these conditions.FundingGlaxoSmithKline Biologicals SA. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 19, 2018 Category: Dermatology Source Type: research

A Simulation-Based Workshop to Improve Dermatologists ’ Communication Skills: A Pilot for Continuing Medical Education
ConclusionsParticipants reported that this communication workshop effectively satisfied its learning objectives. Opportunities to practice and improve communication skills as part of continuing medical education will benefit the clinical experience of patients and physicians alike, and the workshop may be formatted to serve physicians of other specialties. The lowest-scoring communication areas identified in this study present an opportunity to develop a tailored curriculum for physician –patient communication in the future. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 17, 2018 Category: Dermatology Source Type: research

A Case of Acute Pemphigus Vulgaris Relapses Associated with Cocaine Use and Review of the Literature
We present the clinical case of the patient, followed for a total of 86  weeks, with ten relapses secondary to probable cocaine use. The patient was admitted to the emergency department after presenting polymorphic dermatosis characterized by blisters, vesicles, and excoriations extending from the oral cavity to the thorax, and to the inguinal and genital regions, aff ecting approximately 35 % of the body surface area with a score of 56 on the Pemphigus Skin Disorder Index. Skin biopsies were compatible with PV diagnosis. The patient had clinical improvement with a combination of methylprednisolone 500 ...
Source: Dermatology and Therapy - November 10, 2018 Category: Dermatology Source Type: research

Scoping Review on Use of Drugs Targeting Interleukin 1 Pathway in DIRA and DITRA
ConclusionsEvidence on use of anti-IL-1 drugs in DIRA and DITRA is scarce and based on observational studies. Larger studies with better methodological quality are needed to increase confidence in use of these drugs in patients with DIRA and DITRA. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 3, 2018 Category: Dermatology Source Type: research

Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families
AbstractIntroductionThe impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase  3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both athttp://www.clinicaltrials.gov).MethodsIn both studies, patients aged ≥ 2 years with mild to moderate AD per the Investigator’s Static Global Assessment were randomly assigned 2:1 to receive crisaborole or vehicle twice daily for 28 days. QoL was assessed using the Children’s Dermatology Life Qual...
Source: Dermatology and Therapy - October 22, 2018 Category: Dermatology Source Type: research

Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis
ConclusionThis study identified a number of clinical and genetic features that could help stratify patients who are at higher risk for having PsA and for whom rheumatology referral may be beneficial. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 20, 2018 Category: Dermatology Source Type: research

Secukinumab is Superior to Ustekinumab in Clearing Skin in Patients with Moderate to Severe Plaque Psoriasis (16-Week CLARITY Results)
AbstractIntroductionSecukinumab, a fully human anti-interleukin-17A monoclonal antibody, has demonstrated superior efficacy to ustekinumab in the phase 3b CLEAR study of moderate to severe plaque psoriasis. Here, we report 16-week results from CLARITY, a second head-to-head trial comparing secukinumab with ustekinumab.MethodsIn the phase 3b CLARITY study, patients were randomized 1:1 to receive subcutaneous secukinumab 300  mg or ustekinumab per label. The co-primary objectives were to demonstrate the superiority of secukinumab over ustekinumab at Week 12 in relation to the proportion of patients with (1) 90% or more ...
Source: Dermatology and Therapy - October 17, 2018 Category: Dermatology Source Type: research

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis
ConclusionsThe results of this study highlight the complexity of the comorbidity burden of HS patients and the need for a multidisciplinary approach to optimize the management of HS and its numerous associated comorbidities.FundingAbbVie, Inc. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 10, 2018 Category: Dermatology Source Type: research

A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
We present a case of nail psoriasis successfully treated with low-dose intralesional methotrexate with no significant side effects in a 48-year-old psoriatic patient. Given the various side effects of conventional topical and systemic therapies limiting their use, we conclude that intralesional methotrexate injection seems to be a safe and effective treatment option for nail psoriasis. However, large controlled studies are needed. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 25, 2018 Category: Dermatology Source Type: research

Disease Burden and Treatment Patterns of Psoriasis in Russia: A Real-World Patient and Dermatologist Survey
ConclusionResults demonstrate a substantial disease burden on psoriasis patients in Russia, despite receiving treatment for their psoriasis, as well as low patient/dermatologist concordance of views on treatment outcomes. These findings also highlight a need to further incorporate the patient ’s views into treatment decision-making in Russia.FundingNovartis Pharma AG, Basel, Switzerland. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 19, 2018 Category: Dermatology Source Type: research

Acral Melanoma: A Patient ’s Experience and Physician’s Commentary
This article, co-authored by a patient diagnosed with acral melanoma, discusses the patient ’s experience of being diagnosed with and treated with surgery for this disease. The physician discusses the epidemiology, genetics, diagnosis, treatment, and prognosis of acral melanoma. Follow-up care plans are also discussed. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 18, 2018 Category: Dermatology Source Type: research

Topical Selenium Sulfide for the Treatment of Hyperkeratosis
In conclusion, we recommend that topical selenium sulfide be added to the therapeutic armamentarium for congenital or acquired hyperkeratosis —particularly for those patients with involvement of their palms and soles. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 10, 2018 Category: Dermatology Source Type: research

Treatment of Atopic Dermatitis with Biologic Drugs
AbstractAtopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease which predominately affects children and usually clears up during infancy or childhood. However, AD may persist with a chronic relapsing course until adulthood or develop at a later age. AD treatment can often be complicated. Treating moderate-to-severe AD can be challenging: only a few therapeutic options are available, with cyclosporine being the only approved and labeled systemic drug. In the last few years, advances in the knowledge of AD pathogenesis have been made that can provide the basis for developing new topical and systemic drugs. ...
Source: Dermatology and Therapy - September 4, 2018 Category: Dermatology Source Type: research

Building a Citizen Pscientist: Advancing Patient-Centered Psoriasis Research by Empowering Patients as Contributors and Analysts
ConclusionWith the growing influence of the internet and technology in society, medical research can be enhanced by crowdsourcing and online patient portals. Patient discovery charts focused on the topics of psoriatic disease demographics, clinical features, environmental triggers, and quality of life. Patients noted that the CP platform adds to their well-being and allows them to express what research questions matter most to them in a direct and quantifiable way. The implementation of CP is a successful and novel method of allowing patients to engage in research. Thus, CP is an important tool to promote patient-centered ...
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Topical Application of 5-Fluorouracil Associated with Distant Seborrheic Dermatitis-like Eruption: Case Report and Review of Seborrheic Dermatitis Cutaneous Reactions after Systemic or Topical Treatment with 5-Fluorouracil
ConclusionWe describe a patient with a seborrheic dermatitis eruption after topical application of 5-fluorouracil at a distant site. The etiologic association between the drug and adverse effect was confirmed with multiple cycles of application and discontinuation of the offending agent. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association?
This article shows the potential for malignant transformation in lichen planus disease and highlights the importance of periodic clinical follow-up. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Patient Reported Improvement After Patch Testing and Allergen Avoidance Counseling: A Retrospective Analysis
We examined positive patch test results considered of definite, probable or possible relevance to the patient’s eczematous eruptions. Patients reported improvement after patch testing as a percentage: 0–100%. Patients were categorized into four groups: (1) those that reported no improvement or worsened, (2) those that reported> 0% and ≤ 60% improvement, (3) those that reported> 60% but
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Beneficial Effects of Antioxidant Furfuryl Palmitate in Non-pharmacologic Treatments (Prescription Emollient Devices, PEDs) for Atopic Dermatitis and Related Skin Disorders
ConclusionStudies performed up to now showed that furfuryl derivatives can efficaciously contrast signs and symptoms of mild-to-moderate AD, erythema, and widespread diffuse cutaneous pathologies in both adult and pediatric patients, representing a real alternative to steroids and a valid aid in the treatment of skin disorders, with no side effects and without requiring precautions in use.FundingRelife S.r.l. - Menarini Group.Plain Language SummaryPlain language summary available for this article. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Development of Low-Cost Locally Sourced Two-Component Compression Bandages in Western Kenya
ConclusionsLow-cost locally sourced two-component compression bandages have been developed for use in Western Kenya. Their use has been initiated at an AMPATH health center and is poised to meet the need for affordable compression therapy options in Western Kenya. Studies evaluating their efficacy in chronic leg ulcers and Kaposi sarcoma lymphedema are ongoing. Future work should address adaptation of compression bandages for optimal use in Western Kenya and evaluate reproducibility of these bandages in similar settings, as well as consider home- or community-based care delivery models to mitigate transportation costs asso...
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

A Rapid and Cost-Effective Device for Testing Minimal Erythema Dose
ConclusionWe designed an MED testing device that is quick, accurate, cost-effective, and easy to use in the setting of a busy phototherapy practice. This device therefore has many advantages over existing MED testing approaches. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

A Single-Arm, Open-Label, Phase IV Study to Evaluate the Efficacy of a Topical Formulation for Hyperkeratotic Actinic Keratosis Lesions
AbstractIntroductionActinic keratosis (AKs) are epidermal lesions that commonly occur in skin exposed to chronic cumulative UV irradiation. Untreated AK lesions can advance to squamous cell carcinoma. Current treatments of AK have many shortcomings; for instance, not all treatments can be used for the hyperkeratotic form of AK. The aim of this study was to test the efficacy and tolerability of a topical product containing 2,4,6-octatrienoic acid and urea for the treatment of hyperkeratotic AK lesions.MethodsForty male and female subjects with at least two hyperkeratotic AK lesions were enrolled in this single-arm, open-lab...
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Basal Cell Carcinoma: A Patient and Physician ’s Experience
AbstractIn this article, the first coauthor, a patient with a basal cell carcinoma on her upper lip, discusses her experience with Mohs micrographic surgery for the treatment of the skin cancer. The second coauthor, who is the patient ’s physician (a dermatologist who shares her last name but is not a relative), diagnosed her skin cancer and referred her for Mohs surgery. The third coauthor, who is the patient’s son and not only a dermatologist, but also a dermatopathologist and a Mohs surgeon (and also shares her last name), summarizes the presentation and treatment of the basal cell carcinoma. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Daily Application of an Aqueous, Acidifying, Peelable Nail Polish versus Weekly Amorolfine for Topical Onychomycosis Treatment: A Prospective, Randomized, Blinded Trial
AbstractIntroductionOnychomycosis is a fungal nail infection, frequently caused by dermatophytes, which occurs in 2 –14% of Western adults. The present study was set up to evaluate the efficacy and safety of a water-based, peelable nail polish (daily application), which acidifies the nail environment, versus a 5% amorolfine nail lacquer (weekly application) for topical treatment of mild-to-moderate onychomycosi s.MethodsOne hundred two adults were randomized in this open, prospective, blinded trial. Clinical efficacy was evaluated at baseline and days 30, 60, 120, and 180, respectively. All patients underwent microbi...
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Efficacy Endpoints in Clinical Trials in Actinic Keratosis
ConclusionThe main endpoints presently in use for the assessment of short- and long-term efficacy of actinic keratosis field-directed therapy, namely, complete clearance and recurrence rate, are obsolete and should be replaced by the percentage reduction in actinic keratosis count or the absolute actinic keratosis count.FundingLEO Pharma A/S. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research

Trichotillomania and Trichophagia: Modern Diagnostic and Therapeutic Methods
AbstractTrichotillomania is a chronic, mental disease of impulse control, characterized by repetitive, compulsive, and self-induced hair pulling. It can occur at any age but is observed more often in adolescents, with a strong predominance in females. Diagnosis of trichotillomania may be difficult, and its effective treatment challenging. The aim of this study is to critically review current literature regarding diagnostic procedures and treatment of trichotillomania, including psychotherapy,N-acetylcysteine, naltrexone, topiramate, atypical neuroleptics, and selective serotonin-reuptake inhibitors. The importance of coope...
Source: Dermatology and Therapy - September 1, 2018 Category: Dermatology Source Type: research