Risk of Cutaneous T Cell Lymphoma with Psoriasis Biologic Therapies
ConclusionOur findings indicate that the development of CTCL is rare in the setting of psoriasis biologic use. Of the limited number of cases of CTCL found, most were in the setting of TNF inhibitor use and no cases of CTCL were reported in the setting of IL-23 inhibitor use. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 3, 2023 Category: Dermatology Source Type: research
Commentary: Unmet Needs in Generalized Pustular Psoriasis in Clinical Practice
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 2, 2023 Category: Dermatology Source Type: research
Dietary Factors and Hidradenitis Suppurativa
AbstractHidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition affecting hair follicles in flexural sites. Obesity is considered to be a risk factor for HS occurrence and thought to be associated with increased severity of HS symptoms. Here, we review the literature examining the impact of dietary factors on HS. Moreover, we propose potential mechanistic links between dietary factors and HS pathogenesis, incorporating evidence from both clinical and basic science studies. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 1, 2023 Category: Dermatology Source Type: research
The Diagnostic Workup, Screening, and Treatment Approaches for Patients with Delusional Infestation
This article serves as a guide for dermatologists, psychiatrists, and other clinicians as it reviews the workup and screening that should be considered when managing a patient with delusional infestation and subsequent treatment protocols once the diagnosis has been made. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 1, 2023 Category: Dermatology Source Type: research
Physician- and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries
ConclusionsThese data highlight the significant impact that AA can have beyond hair loss, especially for patients with severe AA. There was substantial physician –patient alignment on severity assessment. Higher physician-rated AA severity was associated with higher levels of patient-reported disease burden, including anxiety and depression, and work and activity impairment. These data may help inform appropriate treatment strategies. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 1, 2023 Category: Dermatology Source Type: research
Summary of Research: Switching Between Adalimumab Reference Product and BI 695501 in Patients with Chronic Plaque Psoriasis (VOLTAIRE-X): A Randomized Controlled Trial
AbstractThis Summary of Research overviews the results of the VOLTAIRE-X study (NCT03210259), which looked at what happened when people with plaque psoriasis continually took the adalimumab reference product (adalimumab RP; known by the brand name Humira®) or switched three times between taking the adalimumab RP and BI 695501 (adalimumab-adbm, known by the brand name Cyltezo®), an adalimumab biosimilar. The VOLTAIRE-X study showed that the pharmacokinetics of adalimumab were similar in people who stayed continuously on adalimumab RP and people who switched between adalimumab RP and adalimumab-adbm. There were no differ...
Source: Dermatology and Therapy - December 1, 2023 Category: Dermatology Source Type: research
Dietary Factors and Hidradenitis Suppurativa
AbstractHidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin condition affecting hair follicles in flexural sites. Obesity is considered to be a risk factor for HS occurrence and thought to be associated with increased severity of HS symptoms. Here, we review the literature examining the impact of dietary factors on HS. Moreover, we propose potential mechanistic links between dietary factors and HS pathogenesis, incorporating evidence from both clinical and basic science studies. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 1, 2023 Category: Dermatology Source Type: research
Real-Life Utility of Basophil Activation Test in the Diagnosis of Immediate Hypersensitivity Drug Reactions
ConclusionsThe sensitivity of BAT for drug allergies is limited, but it can nevertheless be very helpful before contemplating provocation testing in cases of life-threatening drug allergies where patients cannot be rechallenged or in cases of medications for which no other tests are available or their results are ambiguous. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 1, 2023 Category: Dermatology Source Type: research
Real-World Discontinuation and Switching Patterns for Interleukin-Inhibitor Treatments in Patients with Moderate-to-Severe Psoriasis in Japan
ConclusionTreatment modification of IL-inhibitors for PsO was commonly observed and could indicate insufficient disease control and/or incremental economic burden. Discontinuation and switching rates were lowest for RIS regardless of time point and adjustment for patient characteristics. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 29, 2023 Category: Dermatology Source Type: research
Real-Life Utility of Basophil Activation Test in the Diagnosis of Immediate Hypersensitivity Drug Reactions
ConclusionsThe sensitivity of BAT for drug allergies is limited, but it can nevertheless be very helpful before contemplating provocation testing in cases of life-threatening drug allergies where patients cannot be rechallenged or in cases of medications for which no other tests are available or their results are ambiguous. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - November 28, 2023 Category: Dermatology Source Type: research
Psychosocial Burden of Psoriasis: A Systematic Literature Review of Depression Among Patients with Psoriasis
AbstractPsoriasis is associated with various comorbidities with a notable psychosocial burden. This systematic literature review explores the burden of depression in patients with psoriasis, comparing it with that experienced by patients with other chronic medical conditions. Embase via Ovid, PubMed, and Cochrane Database of Systematic Reviews via Ovid were searched for peer-reviewed studies published in English between January 1, 2016 and December 6, 2021 that reported real-world evidence or observational studies involving at least 100 adults (age ≥ 18 years) with general (unspecified) or plaque psoriasis experi...
Source: Dermatology and Therapy - November 23, 2023 Category: Dermatology Source Type: research
