Rapid Improvements in Itch with Tapinarof Cream 1% Once Daily in Two Phase  3 Trials in Adults with Mild to Severe Plaque Psoriasis
ConclusionTapinarof was highly efficacious in reducing pruritus across multiple patient-reported outcome measures, with rapid, statistically significant, and clinically meaningful improvements. The high proportion of patients achieving the treatment target of an itch-free state at week  12 (50%) is a noteworthy clinical outcome for a non-steroidal topical cream in the treatment of mild to severe plaque psoriasis.Trial RegistrationClinical trial registration information: NCT03956355, NCT03983980. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 21, 2023 Category: Dermatology Source Type: research

Safety and Efficacy of Upadacitinib for Atopic Dermatitis in Japan: Analysis of the 3-Year Phase 3 Rising Up Study
ConclusionFor up to 3  years of continuous treatment, upadacitinib was well tolerated in Japanese patients, with a similar safety profile to that of short-term studies and durable long-term response rates for skin clearance and itch improvement.Trial RegistrationClinicalTrials.gov identifier, NCT03661138. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 21, 2023 Category: Dermatology Source Type: research

Comparative Effectiveness and Durability of Biologics in Clinical Practice: Month  12 Outcomes from the International, Observational Psoriasis Study of Health Outcomes (PSoHO)
ConclusionsThese results show the comparative effectiveness of biologics at 6 and 12  months in the real-world setting.Trial RegistrationClinicalTrials.gov identifier EUPAS24207. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 19, 2023 Category: Dermatology Source Type: research

The Burden of Air Pollution on Skin Health: a Brief Report and Call to Action
ConclusionThe synchronized atypical peaks of CO levels and AD-related visits during the summer of 2023 highlight the potential impact of acute air pollution events such as wildfires on air quality and the consequences for skin health. Air pollution, exacerbated by wildfires, can damage the skin through the smoke and chemicals utilized for extinguishing fires, which contain multiple potential allergens and irritants to the skin, such as CO, particulate matter (PM2.5), and ammonium phosphates, triggering airway and skin inflammation and flares of AD. This issue disproportionately affects vulnerable populations, including low...
Source: Dermatology and Therapy - December 16, 2023 Category: Dermatology Source Type: research

Evaluation of a Novel Microfocused Ultrasound with Three ‐Dimensional Digital Imaging for Facial Tightening: A Prospective, Randomized, Controlled Trial
ConclusionsA small sample size, lack of clinical scales, and impersonalized treatment parameters. The novel microfocused ultrasound appears to be a safe and effective modality for lower-face tightening.Clinical Trial Registration NumberChiCTR 2200064666. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 15, 2023 Category: Dermatology Source Type: research

Degree of Alignment Between Japanese Patients and Physicians on Alopecia Areata Disease Severity and Treatment Satisfaction: A Real-World Survey
ConclusionsThis study highlights previously unreported patient-physician misalignment on disease severity, level of treatment dissatisfaction and unmet needs due to the lack of effective treatment. Further study on how improvement of the misalignment between physicians and patients could increase both patient and physician satisfaction with treatment and improve the quality of life for patients with AA. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 11, 2023 Category: Dermatology Source Type: research

Natural History of Keloids: A Sociodemographic Analysis Using Structured and Unstructured Data
ConclusionA large population of patients in the USA with keloids was identified and characterized using structured/unstructured sources. A numerically higher proportion of patients with keloids were non-white; Black patients had larger, more severe keloids at diagnosis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 8, 2023 Category: Dermatology Source Type: research

Risk of Cutaneous T  Cell Lymphoma with Psoriasis Biologic Therapies
ConclusionOur findings indicate that the development of CTCL is rare in the setting of psoriasis biologic use. Of the limited number of cases of CTCL found, most were in the setting of TNF inhibitor use and no cases of CTCL were reported in the setting of IL-23 inhibitor use. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 3, 2023 Category: Dermatology Source Type: research

Commentary: Unmet Needs in Generalized Pustular Psoriasis in Clinical Practice
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - December 2, 2023 Category: Dermatology Source Type: research