The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing
ConclusionThe ADE-G2-based cream proved to be effective and well tolerated in real-life conditions for the management of minor skin impairment in a large and varied cohort of subjects. This product, used as a standalone or adjunctive regimen, can help accelerate the healing of various types of superficial skin impairment. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 7, 2024 Category: Dermatology Source Type: research
Safety of Secukinumab from 1 Million Patient-Years of Exposure: Experience from Post-Marketing Setting and Clinical Trials
ConclusionSecukinumab safety profile with increased patient exposure remained favorable. Paradoxical skin reactions were identified in post-marketing monitoring. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 7, 2024 Category: Dermatology Source Type: research
The Need of Differential Diagnosis Between Vulvar Lichen Sclerosus and Autoimmune Dermatoses in Adolescent Girls
AbstractIntroductionVulvar lichen sclerosus (VLS) is a chronic inflammatory condition affecting the anogenital region, which can manifest in prepubertal or adolescent patients. The prevailing theories point to autoimmune and genetic factors. The primary symptoms of VLS typically include vulvar itching, discomfort, dysuria, and constipation. Physical examination often reveals a characteristic figure 8 pattern, involving the labia minora, clitoral hood, and perianal region. However, these symptoms and the age of onset are nonspecific and require differentiation from autoimmune dermatoses such as bullous diseases, pemphigus...
Source: Dermatology and Therapy - March 7, 2024 Category: Dermatology Source Type: research
A Prospective, Monocentric Case-Control Study on Uncontrolled Psoriasis as Independent Risk Factor for a Hypercoagulable State
ConclusionThis is the first prospective study comparing the CLP of psoriasis patients with that of HC. A significant increase in both amplitude and area under the curve, indicative of a hypercoagulable CLP, was observed in psoriasis patients compared to HC. After successful anti-inflammatory treatment, amplitude significantly decreased. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 7, 2024 Category: Dermatology Source Type: research
The Role of the Gut-Joint Axis in the Care of Psoriatic Arthritis: A Two-Sample Bidirectional Mendelian Randomization Study
ConclusionThis two-sample bidirectional Mendelian randomization analysis suggested that the gut microbiota had a causal effect on psoriatic arthritis and implied the potential role of probiotics in the management and prevention of psoriatic arthritis. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 7, 2024 Category: Dermatology Source Type: research
The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing
ConclusionThe ADE-G2-based cream proved to be effective and well tolerated in real-life conditions for the management of minor skin impairment in a large and varied cohort of subjects. This product, used as a standalone or adjunctive regimen, can help accelerate the healing of various types of superficial skin impairment. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 7, 2024 Category: Dermatology Source Type: research
Treatment Patterns and Negative Health Outcomes in Palmoplantar Pustulosis Patients in Germany and the US
ConclusionsEstablishing treatment guidelines remains an unmet need for patients with PPP and could improve quality of life by reducing the occurrence of negative health outcomes. The findings from this study may provide insight into the effectiveness of current treatment options for patients with PPP and can be leveraged to support the development of treatment guidelines. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 5, 2024 Category: Dermatology Source Type: research
Successful Treatment of Disseminated Granuloma Annulare with Upadacitinib
We report the case of a woman in her 50s with a 2-year history of DGA refractory to multiple treatments. Given the recent evidence of the role of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in the granuloma annulare pathophysiology, treatment with upadacitinib 30 mg per day was started with rapid effectiveness and good tolerance. This case underscores the potential of JAK inhibitors as promising therapeutic options for recalcitrant granuloma annulare. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 5, 2024 Category: Dermatology Source Type: research
Response to “Letter to the Editor Regarding ‘Matching-Adjusted Indirect Comparison of the Long-Term Efficacy Maintenance and Adverse Event Rates of Lebrikizumab vs. Dupilumab in Moderate to Severe Atopic Dermatitis’”
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 5, 2024 Category: Dermatology Source Type: research
Treatment Patterns and Negative Health Outcomes in Palmoplantar Pustulosis Patients in Germany and the US
ConclusionsEstablishing treatment guidelines remains an unmet need for patients with PPP and could improve quality of life by reducing the occurrence of negative health outcomes. The findings from this study may provide insight into the effectiveness of current treatment options for patients with PPP and can be leveraged to support the development of treatment guidelines. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 5, 2024 Category: Dermatology Source Type: research
Successful Treatment of Disseminated Granuloma Annulare with Upadacitinib
We report the case of a woman in her 50s with a 2-year history of DGA refractory to multiple treatments. Given the recent evidence of the role of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in the granuloma annulare pathophysiology, treatment with upadacitinib 30 mg per day was started with rapid effectiveness and good tolerance. This case underscores the potential of JAK inhibitors as promising therapeutic options for recalcitrant granuloma annulare. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 5, 2024 Category: Dermatology Source Type: research
Response to “Letter to the Editor Regarding ‘Matching-Adjusted Indirect Comparison of the Long-Term Efficacy Maintenance and Adverse Event Rates of Lebrikizumab vs. Dupilumab in Moderate to Severe Atopic Dermatitis’”
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 5, 2024 Category: Dermatology Source Type: research
Effect of Makeup Use on Depressive Symptoms: An Open, Randomized and Controlled Trial
ConclusionThe results show that encouraging the frequent use of makeup, a practice that can be achieved by most people and which is simple and inexpensive to implement, can contribute to effective and sustainable improvement in the well-being and mental health of a significant portion of the population. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 1, 2024 Category: Dermatology Source Type: research
Botulinum Toxin A and B for Palmoplantar Hyperhidrosis
ConclusionWe found that BTX-A and BTX-B treatment for palmar hyperhidrosis and BTX-B treatment for plantar hyperhidrosis led to a substantial improvement of QoL. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 1, 2024 Category: Dermatology Source Type: research
Integrating the 40-Gene Expression Profile (40-GEP) Test Improves Metastatic Risk-Stratification Within Clinically Relevant Subgroups of High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) Patients
ConclusionThe 40-GEP test demonstrates accurate, independent, clinically actionable stratification of metastatic risk and improves predictive accuracy when integrated into risk classification systems. The improved accuracy of risk assessment when including tumor biology via the 40-GEP test ensures more risk-aligned, personalized patient management decisions. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 1, 2024 Category: Dermatology Source Type: research
