Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2
ConclusionAcross all degrees of severity for baricitinib 2 mg and 4 mg doses, the proportion of patients responding was yet to plateau up to week 52. Response to treatment was longer for patients with a baseline SALT score 95–100. Further studies are needed to analyze other parameters that may impact observed response rates. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study
ConclusionXG-PP provided a comparable efficacy to hydrocortisone ointment in managing AD, thus representing a safe and effective steroid-sparing alternative in pediatric patients with AD.Trial RegistrationRetrospectively registered on 24 November 2021 in the ISRCTN registry: 11118799. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Cost-Effectiveness of Secukinumab Versus Other Biologics in the Treatment of Moderate-to-Severe Plaque Psoriasis: The Chinese Healthcare System Perspective
ConclusionSecukinumab is the most cost-effective treatment option for patients with moderate-to-severe psoriasis compared with other commonly used biologics from the Chinese healthcare system perspective. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Calcipotriol and Betamethasone Dipropionate Cream Based on PAD Technology for the Treatment of Plaque Psoriasis: A Narrative Review
This article aims to summarize the most relevant published evidence about CAL/BDP PAD-cream and its underlying PAD Technology. The PAD Technology enables CAL and BDP stability in an aqueous cream through a multimolecular shell structure, as well as it increases the penetration of both active ingredients into the epidermis and dermis. This technology also demonstrated to increase the cosmetic acceptability and to provide the desirable sensory properties for a topical psoriasis treatment. Two phase III clinical trials have been conducted so far with CAL/BDP PAD-cream. Findings from both trials revealed high efficacy with a f...
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2
ConclusionAcross all degrees of severity for baricitinib 2 mg and 4 mg doses, the proportion of patients responding was yet to plateau up to week 52. Response to treatment was longer for patients with a baseline SALT score 95–100. Further studies are needed to analyze other parameters that may impact observed response rates. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm
ConclusionOverall, randomized controlled trials are needed to evaluate various treatment regimens for DCS and provide patients with a robust, evidence-based approach to therapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature
This study critically appraises the available literature on all topical treatments of psoriasis from the past 20 years to address some relevant issues, such as the vehicle associated with the highest effectiveness, the best vehicle for improving patient adherence, and the best strategy in terms of efficacy and safety for long-term treatment. The greater effectiveness of the foam formulation was demonstrated for calcipotriene/betamethasone dipropionate (Cal/BD) administration compared with the gel and ointment. Without a direct comparison, matching-adjusted indirect comparison analyses support the superiority of the foam ve...
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Public Perceptions, Factors, and Incentives Influencing Patient Willingness to Share Clinical Images for Artificial Intelligence-Based Healthcare Tools
ConclusionsThis study demonstrates overall public support for sharing images to AI-based tools in dermatology, with influencing factors including image type, context, education level, technology comfort, social media use, and monetary compensation. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Burden of Herpes Zoster Among Patients with Psoriasis in the United States
ConclusionThese findings show the increased incidence of HZ among patients with PsO and the clinical and economic burdens of HZ in this population. Considering the high prevalence of PsO, insights into the impact of HZ in these patients provide valuable evidence to inform clinical decision-making.Graphical abstract (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm
ConclusionOverall, randomized controlled trials are needed to evaluate various treatment regimens for DCS and provide patients with a robust, evidence-based approach to therapy. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Topical Treatment for the Management of Mild-to-Moderate Psoriasis: A Critical Appraisal of the Current Literature
This study critically appraises the available literature on all topical treatments of psoriasis from the past 20 years to address some relevant issues, such as the vehicle associated with the highest effectiveness, the best vehicle for improving patient adherence, and the best strategy in terms of efficacy and safety for long-term treatment. The greater effectiveness of the foam formulation was demonstrated for calcipotriene/betamethasone dipropionate (Cal/BD) administration compared with the gel and ointment. Without a direct comparison, matching-adjusted indirect comparison analyses support the superiority of the foam ve...
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Public Perceptions, Factors, and Incentives Influencing Patient Willingness to Share Clinical Images for Artificial Intelligence-Based Healthcare Tools
ConclusionsThis study demonstrates overall public support for sharing images to AI-based tools in dermatology, with influencing factors including image type, context, education level, technology comfort, social media use, and monetary compensation. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Burden of Herpes Zoster Among Patients with Psoriasis in the United States
ConclusionThese findings show the increased incidence of HZ among patients with PsO and the clinical and economic burdens of HZ in this population. Considering the high prevalence of PsO, insights into the impact of HZ in these patients provide valuable evidence to inform clinical decision-making.Graphical abstract (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 22, 2023 Category: Dermatology Source Type: research
Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study
ConclusionThe primary objective to demonstrate a non-flat dose –response relationship and proof-of-concept was not achieved; improvements with spesolimab occurred in secondary endpoints and in non-Asian patients, indicating potential modest benefits. Spesolimab was generally well tolerated (ClinicalTrials.gov NCT04015518). (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 20, 2023 Category: Dermatology Source Type: research
Responsiveness and Minimal Clinically Important Difference of the Infants and Toddlers Dermatology Quality of Life Questionnaire
ConclusionsResponsiveness for all age-specific versions of the InToDermQoL questionnaire was confirmed. MCIDs for the InToDermQoL are proposed as follows: 3-point change of the total score for age version 0 –11 months and 5-point for the age versions 1–2 years and 3–4 years. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 20, 2023 Category: Dermatology Source Type: research
