A Review of the Diagnostic and Therapeutic Gaps in Rosacea Management: Consensus Opinion
We present the recently approved microencapsulated benzoyl peroxide as an effective topical treatment option for papulopustular rosacea. Benzoyl peroxide (BPO) has been used in acne management for many years; however, many clinicians perceive treatment of rosacea with any BPO formulation to be counterintuitive because of concerns of potential skin irritation, while the lack of an accepted mechanism of action on rosacea pathophysiology means that others may be hesitant to use BPO as a treatment. Minocycline foam 1.5% is also an option for the treatment of inflammatory lesions in rosacea, with a decreased risk of systemic ad...
Source: Dermatology and Therapy - January 9, 2024 Category: Dermatology Source Type: research
Correction to: Real-Life Utility of Basophil Activation Test in the Diagnosis of Immediate Hypersensitivity Drug Reactions
(Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 9, 2024 Category: Dermatology Source Type: research
Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review
ConclusionsDrugs and vaccines may be implicated in the aggravation of PsA. Possible mechanisms include cytokine imbalance, immune dysregulation, or inadequate PsA treatment response compared with psoriasis. Most reports are case based without controls, so more studies are needed to further prove the causality. However, early recognition of factors causing or aggravating PsA is important to prevent the irreversible joint damage. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
The Microbiome and Acne: Perspectives for Treatment
AbstractThe skin microbiome consists of the microorganisms populating the human skin.Cutibacterium acnes (C. acnes, formerly namedPropionibacterium acnes) is recognized as a key factor in acne development, regulating inflammatory and immune pathways. Dysbiosis has been described as the imbalance in skin microbiome homeostasis and may play a role in acne pathogenesis. Microbial interference has been shown to be a contributor to healthy skin homeostasis and staphylococcal strains may exclude acne-associatedC. acnes phylotypes. In this review we present an update on the skin microbiome in acne and discuss how current acne...
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
Cutaneous Components Leading to Pruritus, Pain, and Neurosensitivity in Atopic Dermatitis: A Narrative Review
In conclusion, understanding the dynamic interactions between cutaneous components in AD could drive the development of therapies to improve the quality of life for patients with AD. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
An Atlas of the Hidradenitis Suppurativa Transcriptome
ConclusionsOur study provides novel insights into the mechanisms underlying the pathogenesis of HS, and the results also have potential clinical implications in both diagnosis and therapeutics. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
Burden of Hidradenitis Suppurativa: A Systematic Literature Review of Patient Reported Outcomes
ConclusionsAll included studies reported a negative impact of HS on patients ’ lives. A diverse set of disease- and non-disease-specific PRO instruments were utilized highlighting the need for more consistent use of HS-specific validated PRO instruments to assess the impact of HS on the different aspects of patients’ HRQoL to allow for data to be more meaningfully interp reted and compared in real-world settings. Patients with HS need better disease management approaches that address the observed low quality of life. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review
ConclusionsDrugs and vaccines may be implicated in the aggravation of PsA. Possible mechanisms include cytokine imbalance, immune dysregulation, or inadequate PsA treatment response compared with psoriasis. Most reports are case based without controls, so more studies are needed to further prove the causality. However, early recognition of factors causing or aggravating PsA is important to prevent the irreversible joint damage. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
The Microbiome and Acne: Perspectives for Treatment
AbstractThe skin microbiome consists of the microorganisms populating the human skin.Cutibacterium acnes (C. acnes, formerly namedPropionibacterium acnes) is recognized as a key factor in acne development, regulating inflammatory and immune pathways. Dysbiosis has been described as the imbalance in skin microbiome homeostasis and may play a role in acne pathogenesis. Microbial interference has been shown to be a contributor to healthy skin homeostasis and staphylococcal strains may exclude acne-associatedC. acnes phylotypes. In this review we present an update on the skin microbiome in acne and discuss how current acne...
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
Cutaneous Components Leading to Pruritus, Pain, and Neurosensitivity in Atopic Dermatitis: A Narrative Review
In conclusion, understanding the dynamic interactions between cutaneous components in AD could drive the development of therapies to improve the quality of life for patients with AD. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
An Atlas of the Hidradenitis Suppurativa Transcriptome
ConclusionsOur study provides novel insights into the mechanisms underlying the pathogenesis of HS, and the results also have potential clinical implications in both diagnosis and therapeutics. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
Burden of Hidradenitis Suppurativa: A Systematic Literature Review of Patient Reported Outcomes
ConclusionsAll included studies reported a negative impact of HS on patients ’ lives. A diverse set of disease- and non-disease-specific PRO instruments were utilized highlighting the need for more consistent use of HS-specific validated PRO instruments to assess the impact of HS on the different aspects of patients’ HRQoL to allow for data to be more meaningfully interp reted and compared in real-world settings. Patients with HS need better disease management approaches that address the observed low quality of life. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 6, 2024 Category: Dermatology Source Type: research
Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis
ConclusionMaintenance of an acidic skin surface pH and delivery of physiologic lipids are beneficial for skin health and may help improve AD control by reducing sensitivity to irritants and allergens. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 4, 2024 Category: Dermatology Source Type: research
Real-World Effectiveness of Dupilumab in Adult and Adolescent Patients with Atopic Dermatitis: 2-Year Interim Data from the PROSE Registry
ConclusionsIn the real-world PROSE registry, patients with moderate-to-severe AD experienced sustained improvement in disease control, symptoms, and quality of life up to 2 years after initiating dupilumab treatment. Safety data were consistent with the known safety profile of dupilumab.Trial RegistrationClinicalTrials.gov identifier: NCT 03428646.Video abstract (MP4 20,717 kb) (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 4, 2024 Category: Dermatology Source Type: research
Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis
ConclusionMaintenance of an acidic skin surface pH and delivery of physiologic lipids are beneficial for skin health and may help improve AD control by reducing sensitivity to irritants and allergens. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 4, 2024 Category: Dermatology Source Type: research
