Emerging Medical Therapies in Rosacea: A Narrative Review
AbstractRosacea is a chronic inflammatory disease with a multifactorial pathogenesis. The wide spectrum of clinical phenotypes, including erythema, telangiectasia, inflammatory papules and pustules, and phyma, demand an individualized approach to treatment. This narrative review offers an updated reference for rosacea management by covering the latest developments in both topical and systemic treatments, including data from newly approved therapies, updates to current treatment modalities and ongoing clinical trials. Although use of benzoyl peroxide as a treatment for rosacea has typically been limited due to irritation, t...
Source: Dermatology and Therapy - October 12, 2023 Category: Dermatology Source Type: research
Short-, Mid-, and Long-Term Efficacy of Deucravacitinib Versus Biologics and Nonbiologics for Plaque Psoriasis: A Network Meta-Analysis
ConclusionsPatients receiving deucravacitinib were more likely to achieve PASI 75 response versus apremilast and methotrexate across all time points. The long-term PASI 75 response rate for deucravacitinib was similar to those of adalimumab and ustekinumab. The approval of deucravacitinib offers patients the choice of an oral therapy with long-term efficacy similar to that of some biologics. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 6, 2023 Category: Dermatology Source Type: research
Evaluating the Appropriateness of Existing Health-Related Quality of Life Measures in Lichen Planus
ConclusionsThe psychometric and qualitative findings support the use of the OLPSSM and Scalpdex within specific LP subtypes but cautioned use of the DLQI. Administration of the ESS is not recommended in LP because of its poor psychometric performance. Given these limitations, further validation of non-specific disease measures is needed and/or the development of additional LP-specific PROMs.Trial RegistrationNCT04300296. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 5, 2023 Category: Dermatology Source Type: research
Association Between Poor Sleep and Myocardial Infarction in Patients with Psoriasis: Findings from a Cross-Sectional Study with the National Psoriasis Foundation
ConclusionOur analyses indicate an association between sleep quantity and history of myocardial infarction in patients with psoriasis. For each hour increase in average nightly sleep, patients with psoriasis have a 33% decrease in the odds of having a history of myocardial infarction. The chief limitation of this study is its cross-sectional design limiting ascertainment of causality. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 5, 2023 Category: Dermatology Source Type: research
Evaluating the Appropriateness of Existing Health-Related Quality of Life Measures in Lichen Planus
ConclusionsThe psychometric and qualitative findings support the use of the OLPSSM and Scalpdex within specific LP subtypes but cautioned use of the DLQI. Administration of the ESS is not recommended in LP because of its poor psychometric performance. Given these limitations, further validation of non-specific disease measures is needed and/or the development of additional LP-specific PROMs.Trial RegistrationNCT04300296. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 5, 2023 Category: Dermatology Source Type: research
Association Between Poor Sleep and Myocardial Infarction in Patients with Psoriasis: Findings from a Cross-Sectional Study with the National Psoriasis Foundation
ConclusionOur analyses indicate an association between sleep quantity and history of myocardial infarction in patients with psoriasis. For each hour increase in average nightly sleep, patients with psoriasis have a 33% decrease in the odds of having a history of myocardial infarction. The chief limitation of this study is its cross-sectional design limiting ascertainment of causality. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 5, 2023 Category: Dermatology Source Type: research
Navigating the Multidimensional Impact of Living with Hidradenitis Suppurativa: An In-Depth Netnographic Study on Social Media Platforms
ConclusionBy undertaking a longitudinal analysis of patient interactions, the study aimed to offer a richer understanding of HS, from its diagnosis to its treatment. It underscores the necessity for a more patient-centered approach when managing this condition. We hope that this enhanced understanding can facilitate better care for those affected by HS. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 4, 2023 Category: Dermatology Source Type: research
Neurotrophin-4 and Brain-Derived Neurotrophic Factor Serum Levels in Renal Transplant Recipients with Chronic Pruritus
ConclusionsThe results indicate higher NT-4 serum concentration in RTRs with pruritus compared to RTRs without pruritus. Furthermore, the study revealed a statistically significant, positive correlation between the serum concentration of NT-4 and NRS score. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 1, 2023 Category: Dermatology Source Type: research
Validation of the Peak Pruritus Numerical Rating Scale as a Patient-Reported Outcome Measure in Prurigo Nodularis
ConclusionThe PP NRS is a content-valid and reliable PRO measure for quantifying itch severity in adults with PN in clinical trials.Trial Registration NumberNCT03181503. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 30, 2023 Category: Dermatology Source Type: research
Natural Retinol Analogs Potentiate the Effects of Retinal on Aged and Photodamaged Skin: Results from In Vitro to Clinical Studies
ConclusionThese data suggest that 3RC is a highly effective and well-tolerated treatment for photoaging. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 30, 2023 Category: Dermatology Source Type: research
The Relevant Oral Burden of Patients with Hidradenitis Suppurativa
ConclusionAs a result of the relevant oral burden in patients with HS, dentists should be part of the multidisciplinary team and oral education should be promoted among patients with HS. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 30, 2023 Category: Dermatology Source Type: research
