Correction to: A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia
The original article can be found online. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 25, 2021 Category: Gastroenterology Source Type: research

Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan
ConclusionA simple calculation of the FIB-4 index in diabetes clinics can be the first step toward surveillance of HCC with a non-viral etiology. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 11, 2021 Category: Gastroenterology Source Type: research

Optimal cutoff value of integrated relaxation pressure on the esophagogastric junction to detect outflow obstruction using starlet high-resolution manometry system
ConclusionThe optimal cutoff value of IRP to distinguish achalasia/EGJOO was  ≥ 25 mmHg using the Starlet HRM system in our cohort. This indicates that the current proposed cutoff of 26 mmHg appears to be relevant. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 9, 2021 Category: Gastroenterology Source Type: research

Cabozantinib in Japanese patients with advanced hepatocellular carcinoma: a phase 2 multicenter study
ConclusionsCabozantinib 60  mg/day has a favorable benefit/risk profile for Japanese patients with advanced HCC who have previously received one or two lines of systemic anticancer therapy including sorafenib. (Clinical trial registration: NCT03586973) (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 3, 2021 Category: Gastroenterology Source Type: research

Diagnosis for Wilson disease: this disease may not be a rare disease
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 3, 2021 Category: Gastroenterology Source Type: research

Correction to: Molecular detection and clinicopathological characteristics of advanced/recurrent biliary tract carcinomas harboring the FGFR2 rearrangements: a prospective observational study (PRELUDE Study)
The original article has been corrected. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 30, 2020 Category: Gastroenterology Source Type: research

Direct-acting antivirals improve survival and recurrence rates after treatment of hepatocellular carcinoma within the Milan criteria
ConclusionsDAAs after HCC treatment prevents deterioration of hepatic functional reserve and significantly improves both recurrence and survival rates. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 5, 2020 Category: Gastroenterology Source Type: research

Prevalence of behavioral disorders in patients with vonoprazan-refractory reflux symptoms
AbstractBackgroundBehavioral disorders, such as supragastric belching (SGB) and rumination syndrome (RS), which may be treated by cognitive behavioral therapy, are common in patients with reflux symptoms refractory to proton pump inhibitors (PPI). Vonoprazan (VPZ) has been used as a new type of acid inhibitor in Japan since 2015. We herein investigated the prevalence of behavioral disorders in patients with VPZ-refractory reflux symptoms and attempted to identify predictive factors.MethodsWe retrospectively analyzed esophagogastroduodenograms, high-resolution manometry, and 24-h multiluminal impedance pH-metry (MIIpH) in p...
Source: Journal of Gastroenterology - November 27, 2020 Category: Gastroenterology Source Type: research

The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan
ConclusionsViral hepatitis has remained the main cause of HCC in Japan. However, the decrease in viral hepatitis-related HCC, particularly HCV-related HCC highly contributed to the etiological changes. In addition, the increased incidence of non-viral HCC, particularly NASH-related HCC, was involved in the changing etiologies of HCC-complicated LC in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 20, 2020 Category: Gastroenterology Source Type: research

Tenofovir – disoproxil – fumarate modulates lipid metabolism via hepatic CD36/PPAR-alpha activation in hepatitis B virus infection
ConclusionsTenofovir –disoproxil–fumarate modulates lipid metabolism by upregulating hepatic CD36 via PPAR-α activation. Since dyslipidemia could be associated with arteriosclerosis and hepatocarcinogenesis, these discoveries provide novel insights into anti-HBV therapies, as well as the associated extrahepatic eff ects of NA. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 19, 2020 Category: Gastroenterology Source Type: research

Enhanced endoscopic detection of occult gastric cancer in carriers of pathogenic CDH1 variants
AbstractBackgroundGermline inactivating variants in theCDH1 tumor suppressor gene impart an elevated lifetime risk of diffuse gastric cancer. The current endoscopic surveillance method depends upon random gastric biopsies for early cancer detection.MethodsAsymptomatic adults with pathogenic or likely pathogenicCDH1 variants referred for endoscopic gastric cancer surveillance were included in this retrospective cohort. Upper gastrointestinal endoscopy was performed according to the consensus Cambridge method, in the early period, or a systematic (Bethesda) protocol as part of an ongoing natural history study. The primary ou...
Source: Journal of Gastroenterology - November 18, 2020 Category: Gastroenterology Source Type: research

Proton-pump inhibitors are associated with a high false-positivity rate in faecal immunochemical testing
ConclusionPPIs increase FIT positivity at the expense of FP results. The recommendation to avoid their use before FIT performance could reduce up to 3% of colonoscopies and 9% of FP results. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 7, 2020 Category: Gastroenterology Source Type: research

Wilson disease: revision of diagnostic criteria in a clinical series with great genetic homogeneity
ConclusionSerum ceruloplasmin determination followed by genetic screening would reduce costs and favor the prioritization of non-invasive procedures to reach a definitive diagnosis, even for asymptomatic cases. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 7, 2020 Category: Gastroenterology Source Type: research

Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p
ConclusionsOur findings suggest that circTMEM87A functions as an oncogene through the miR-142-5p/ULK1 axis in GC. CircTMEM87A might be a prognostic biomarker as well as a promising therapeutic target for GC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 6, 2020 Category: Gastroenterology Source Type: research

Ulcerative colitis-related severe enteritis: an infrequent but serious complication after colectomy
ConclusionUCRSE is a rare but serious complication after colectomy and is sometimes life-threatening. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 5, 2020 Category: Gastroenterology Source Type: research

Artificial intelligence automates and augments baseline impedance measurements from pH-impedance studies in gastroesophageal reflux disease
AbstractBackgroundArtificial intelligence (AI) has potential to streamline interpretation of pH-impedance studies. In this exploratory observational cohort study, we determined feasibility of automated AI extraction of baseline impedance (AIBI) and evaluated clinical value of novel AI metrics.MethodspH-impedance data from a convenience sample of symptomatic patients studied off (n = 117, 53.1 ± 1.2 years, 66% F) and on (n = 93, 53.8 ± 1.3 years, 74% F) anti-secretory therapy and from asymptomatic volunteers (n = 115, 29.3 &...
Source: Journal of Gastroenterology - November 5, 2020 Category: Gastroenterology Source Type: research

The gut mycobiome: a novel player in chronic liver diseases
AbstractThe human gut microbiome (bacteria, fungi, viruses, and archaea) is a complex and diverse ecosystem. It plays an important role in human health, but is involved in several intestinal and extraintestinal diseases. Most research to date has focused on the role of bacteria, while studies focusing on fungi (also referred to as “mycobiome” or “fungome”) are still in its infancy. In this review, we focus on the existing literature available about the gut mycobiome with an emphasis on compositional mycobiome changes associated with liver diseases, the impact on pathogenesis of disease, and its pote...
Source: Journal of Gastroenterology - November 5, 2020 Category: Gastroenterology Source Type: research

Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial
ConclusionsIn this double-blind randomized trial, we observed the complete remission at 8 weeks in patients with steroid-resistant UC receiving a high dose of AM.Clinical trial registryJAPIC clinical trials information; Japic CTI-205255 (200410115290).https://www.clinicaltrials.jp/cti-user/trial/Search.jsp. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 2, 2020 Category: Gastroenterology Source Type: research

Clinical outcome of conservatively managed pancreatic intraductal papillary mucinous neoplasms with mural nodules and main duct dilation
This study enrolled 101 IPMN patients exhibiting HRS with follow-up observations at 11 hospitals in Japan (2011 –2016). The median observation period was 37 months (maximum: 86 months). Primary outcomes were estimated 5-year overall survival (OS) and disease-specific survival (DSS). Survival was also stratified based on HRS features.ResultsOf 101 patients, 32 (31.7%) had the main pancreatic duct (MPD) measuring  ≥ 10 mm and 80 (79.2%) had mural nodules measuring ≥ 5 mm. The estimated 5-year OS and DSS were 74% and 91%, respectively. In the stratified analysis, the...
Source: Journal of Gastroenterology - October 28, 2020 Category: Gastroenterology Source Type: research

Molecular detection and clinicopathological characteristics of advanced/recurrent biliary tract carcinomas harboring the FGFR2 rearrangements: a prospective observational study (PRELUDE Study)
ConclusionsFGFR2 rearrangement was identified in ICC and PCC patients, and was associated with younger age and history of hepatitis viral infection. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 26, 2020 Category: Gastroenterology Source Type: research

The influence of familial pancreatic cancer on postoperative outcome in pancreatic cancer: relevance to adjuvant chemotherapy
AbstractBackgroundFamilial pancreatic cancer (FPC) is defined as a family in which at least two first-degree relatives have pancreatic cancer (PC). The prognostic significance of PC in an FPC family after surgery is not fully understood.MethodsThis was a retrospective study of 427 patients who underwent pancreatectomy for pancreatic ductal adenocarcinoma between January 2008 and December 2016. PC patients who also had at least one first-degree relative with PC were defined as FPC patients. The associations between recurrence and clinicopathological characteristics were analyzed for both FPC and non-FPC patients.ResultsFPC ...
Source: Journal of Gastroenterology - October 22, 2020 Category: Gastroenterology Source Type: research

Proteomics analysis identified TPI1 as a novel biomarker for predicting recurrence of intrahepatic cholangiocarcinoma
This study aimed to develop a novel prognostic classifier for patients with ICC after surgery.MethodsUsing a proteomics approach, we screened tumor markers that up-regulated in ICC tissues, and narrowed down by bioinformatics analysis, western blot and immunohistochemistry. Prognostic markers were identified using Cox regression analyses in primary training cohort and the predictive models for time to recurrence (TTR) were established. The predictive accuracy of predictive model was validated in external validation cohort and prospective validation cohort. MTT assay, clonal formation assay and trans-well assays were used t...
Source: Journal of Gastroenterology - October 21, 2020 Category: Gastroenterology Source Type: research

Verrucous esophageal carcinoma is a unique indolent subtype of squamous cell carcinoma: a systematic review and individual patient regression analysis
AbstractBackground and aimsVerrucous esophageal carcinoma (VEC) is a rare malignancy that presents a diagnostic challenge. We aim to characterize the clinical and genomic features, tumor behavior, and treatment outcomes of VEC to guide clinical practice.MethodsWe performed a systematic review of the literature and identified additional cases from Massachusetts General Hospital records and The Cancer Genome Atlas (TCGA). We obtained individual VEC patient data and analyzed publicly available clinicogenomic data from TCGA. We performed a regression analysis comparing cases of VEC to esophageal squamous cell carcinoma (ESCC) ...
Source: Journal of Gastroenterology - October 20, 2020 Category: Gastroenterology Source Type: research

Significance of endoscopic deep small bowel evaluation using balloon-assisted enteroscopy for Crohn ’s disease in clinical remission
ConclusionEven when Crohn's disease is in remission, it is important to evaluate DSB using BAE to assess endoscopic mucosal healing. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 19, 2020 Category: Gastroenterology Source Type: research

The microbiome can predict mucosal healing in small intestine in patients with Crohn ’s disease
ConclusionsFecal microbiome is corelated with disease activity in the entire small intestine in Crohn ’s disease patients. The predictive score proposed by microbiota characteristics was a potential biomarker for mucosal healing in the small intestine. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 16, 2020 Category: Gastroenterology Source Type: research

PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication
ConclusionsWe demonstrated thatPNPLA3 andHLA-DQB1 polymorphisms were associated with HCC after SVR. These findings might be useful to inform risk stratification for HCC surveillance after SVR. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 15, 2020 Category: Gastroenterology Source Type: research

Near-focus magnification and second-generation narrow-band imaging for early gastric cancer in a randomized trial
ConclusionThe diagnostic performance of NF-NBI is good and acceptable for diagnosis of EGC in combination with either WLI or 2G-NBI. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - October 5, 2020 Category: Gastroenterology Source Type: research

Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study
ConclusionsReal-world efficacy of SOF/VEL treatment for patients with decompensated cirrhosis was similar to Japanese phase 3 study, although treatment discontinuation and death related to liver disease occurred. In patients with poor hepatic reserve, whether it improves continuously after viral clearance requires further evaluation. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 30, 2020 Category: Gastroenterology Source Type: research

Post-reflux swallow-induced peristaltic wave (PSPW): physiology, triggering factors and role in reflux clearance in healthy subjects
AbstractBackground and aimsThe underlying physiology of post-reflux swallow-induced peristaltic wave (PSPW) is unclear. We aimed to: 1) calculate the probability of a random association between reflux and PSPW; 2) characterize factors that could underlie triggering of PSPW and 3) assess the chemical clearance effect of PSPW in healthy asymptomatic subjects.MethodsA total of 251 impedance –pH tracings from healthy asymptomatic subjects were analysed. Twenty consecutive tracings from this pool with 20–40 reflux episodes/24 h and a PSPW index higher than 50% were separately analyzed to evaluate the probabilit...
Source: Journal of Gastroenterology - September 28, 2020 Category: Gastroenterology Source Type: research

Secondary prevention for hepatocellular carcinoma in patients with chronic hepatitis B: are all the nucleos(t)ide analogues the same?
AbstractReducing the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) is the key ultimate goal set in essentially all treatment guidelines. There has been solid evidence supporting the relationship between serum hepatitis B virus (HBV) DNA level and risk of HCC. Antiviral treatment with oral nucleos(t)ide analogues (NAs) leads to sustained viral suppression and hence is often adopted as the secondary prevention for HCC in CHB patients. The first-generation NA, lamivudine, reduced the risk of HCC at 3  years compared to placebo; yet, its high emergence of antiviral resistance has m...
Source: Journal of Gastroenterology - September 23, 2020 Category: Gastroenterology Source Type: research

Impact of acute kidney injury on prognosis and the effect of tolvaptan in patients with hepatic ascites
ConclusionsOur study suggests that concomitant AKI significantly worsens survival in Japanese patients with hepatic ascites, and TLV and natriuretic agent combination therapy might lead to an excellent synergistic therapeutic effect of hepatic ascites and inhibition of AKI onset. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 20, 2020 Category: Gastroenterology Source Type: research

Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance
ConclusionsPlasma cfDNA quantification by distinct measurements is useful to predict tumor burden. Through appropriate methods, dPCR-mediated mutation detection in patients with localized PDA and IPMN likely to progress to invasive carcinoma is feasible and complements conventional biomarkers. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 15, 2020 Category: Gastroenterology Source Type: research

Vonoprazan-based triple therapy is effective for Helicobacter pylori eradication irrespective of clarithromycin susceptibility
ConclusionsCAM-resistantH. pylori was prevalent in one-third of patients in the Tokyo metropolitan area. VPZ-based triple therapy was highly effective and well-tolerated irrespective of CAM susceptibility. Therefore, it could be a valuable first-line treatment regimen forH. pylori infection. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 14, 2020 Category: Gastroenterology Source Type: research

Correction to: Retinoic acid receptor γ activation promotes differentiation of human induced pluripotent stem cells into esophageal epithelium
In the original publication of the article, the following errors were noted and corrected in this correction. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 14, 2020 Category: Gastroenterology Source Type: research

Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors
AbstractBackgroundAlthough endoscopic ultrasound (EUS) is reported to be suitable for determining the layer from which subepithelial lesions (SELs) originate, it is difficult to distinguish gastrointestinal stromal tumor (GIST) from non-GIST using only EUS images. If artificial intelligence (AI) can be used for the diagnosis of SELs, it should provide several benefits, including objectivity, simplicity, and quickness. In this pilot study, we propose an AI diagnostic system for SELs and evaluate its efficacy.MethodsThirty sets each of EUS images with SELs ≥ 20 mm or
Source: Journal of Gastroenterology - September 10, 2020 Category: Gastroenterology Source Type: research

Retraction Note to: Lactobacillus casei BL23 regulates T reg and Th17 T-cell populations and reduces DMH-associated colorectal cancer
The Editor-in-Chief has retracted this article [1]. After publication an investigation by the INRAe Research Integrity Board raised concerns about several aspects of the study. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - September 7, 2020 Category: Gastroenterology Source Type: research

Durable response without recurrence to Tolvaptan improves long-term survival
This study aimed to clarify the water retention recurrence rate and the relationship between long-term response without recurrence and prognosis.MethodsAltogether, 100 patients with decompensated cirrhosis treated with tolvaptan were retrospectively analyzed. Recurrence was evaluated according to the criteria of the EASL clinical practice guideline. The recurrence rate and prognosis of non-responders, patients with recurrence, and long-term responders were analyzed. The baseline factors related to short-term response, recurrence, and long-term response were also evaluated.ResultsApproximately 31.0% of the short-term respon...
Source: Journal of Gastroenterology - August 25, 2020 Category: Gastroenterology Source Type: research

Supragastric belching in Japan: lower prevalence and relevance for management of gastroesophageal reflux disease compared to United Kingdom
This study aimed at comparing the role of SGB in GERD patients in Japan and the UK.MethodsWe re-analyzed impedance-pH monitoring tracings from patients who were referred to tertiary centers in Japan and the UK due to PPI-refractory reflux symptoms. The prevalence of excessive SGB and the impact of SGB on reflux symptoms were compared between the two countries.ResultsImpedance-pH tracings from124 Japanese and 83 British patients were re-analyzed. Japanese patients were significantly younger and had smaller body mass index than the British (P 
Source: Journal of Gastroenterology - August 23, 2020 Category: Gastroenterology Source Type: research

Real-time assessment of video images for esophageal squamous cell carcinoma invasion depth using artificial intelligence
ConclusionsMost diagnostic parameters were higher when done by the AI system than by the experts. These results suggest that our AI system could potentially provide useful support during endoscopies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 9, 2020 Category: Gastroenterology Source Type: research

Solving the questions regarding 5-aminosalitylate formulation in the treatment of ulcerative colitis
Abstract5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal 5-aminosalicylate is effective for proctitis, physicians should endeavor to reduce patient's distress when administering suppositories or enema as the first-line therapy. It should be clarified whether oral 5-aminosalicylate alone with a drug delivery system that allows higher 5-aminosalicylate concent...
Source: Journal of Gastroenterology - August 9, 2020 Category: Gastroenterology Source Type: research

Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19
AbstractBackgroundCOVID-19 has emerged as a threat to human health. Liver dysfunction has been reported to occur frequently in patients with COVID-19, although its significance has not yet been elucidated.MethodsThe subjects were 35 patients with COVID-19, and clinical characteristics were retrospectively analyzed. COVID-19 patients requiring ventilator were classified as having severe COVID-19.ResultsAll 35 patients were diagnosed as having mild-to-moderate COVID-19 at admission, but the severity aggravated to severe in 8 patients (22.9%) in hospital. Hepatocellular-type liver injury, defined as elevation of the serum AST...
Source: Journal of Gastroenterology - August 8, 2020 Category: Gastroenterology Source Type: research

Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs
ConclusionM2BPGi at SVR is a potential predictor for patients ’ survival and a candidate biomarker for detecting individuals who are at greater risk of death due to cancer-related and unrelated to HCV, as well as cardiovascular diseases, after viral eradication. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 7, 2020 Category: Gastroenterology Source Type: research

The long-term outcomes of patients with immunoglobulin G4-related sclerosing cholangitis: the Mayo Clinic experience
ConclusionsIn a cohort of IgG4-SC patients, 88% of whom were treated with immunosuppressive drugs, the risk of cirrhosis and CCA was significantly lower compared to an age- and gender-matched group with PSC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 7, 2020 Category: Gastroenterology Source Type: research

Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments
AbstractChanges in body composition are associated with poor outcomes in cancer patients including hepatocellular carcinoma (HCC). Sarcopenia, defined as the loss of skeletal muscle mass, quality and function, has been associated with a higher rate of complications and recurrences in patients with cirrhosis and HCC. The assessment of patient general status before HCC treatment, including the presence of sarcopenia, is a key-point for achieving therapy tolerability and to avoid short- and long-term complications leading to poor patients ’ survival. Thus, we aimed to review the current literature evaluating the role of...
Source: Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Source Type: research

Systemic treatment options for advanced biliary tract carcinoma
AbstractAdvanced biliary  tract cancers (BTC) include a diverse collection of rare and heterogenous tumors with poor prognosis. The combination of gemcitabine and cisplatin is the established first-line therapy for advanced BTC. There are no accepted standard treatments in the second line setting, though there are sev eral ongoing clinical trials that implement chemotherapy as a therapeutic strategy. The understanding of the molecular landscape of BTC has offered hope of targeted therapies to the identified actionable genomic aberrations, such as FGFR2 gene fusions, mutations of IDH1/2, HER2, ...
Source: Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Source Type: research

Targeting the immune milieu in gastrointestinal cancers
AbstractGastrointestinal (GI) cancers are among the most common and lethal solid tumors worldwide. Unlike in malignancies such as lung, renal and skin cancers, the activity of immunotherapeutic agents in GI cancers has, on the whole, been much less remarkable and do not apply to the majority. Furthermore, while incremental progress has been made and approvals for use of immune checkpoint inhibitors (ICIs) in specific subsets of patients with GI cancers are coming through, in a population of ‘all-comers’, it is frequently unclear as to who may benefit most due to the relative lack of reliable predictive biomarke...
Source: Journal of Gastroenterology - August 2, 2020 Category: Gastroenterology Source Type: research

Symptom-based diagnostic approach for eosinophilic esophagitis
AbstractThe prevalence of eosinophilic esophagitis (EoE) has been increasing in Japan. Although the diagnosis of EoE is based on simple criteria that include the presence of esophageal symptoms and esophageal eosinophilia on biopsies, there are several important issues associated with the diagnostic approach. Following an extensive literature search, the symptoms of 886 EoE cases in Japanese adults were analyzed and divided into three categories as follows: (1) typical symptoms, such as dysphagia (53%); (2) other upper GI symptoms (40%); and (3) no symptoms found during screening or medical examination, i.e., “asympt...
Source: Journal of Gastroenterology - July 26, 2020 Category: Gastroenterology Source Type: research

Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort
AbstractBackgroundPain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain experience in RAP/CP patients.StudyA retrospective study was done using North American Pancreatitis Study II (NAPS2) genotyped RAP and CP patients with completed case report forms (n = 1,357). Subj...
Source: Journal of Gastroenterology - July 16, 2020 Category: Gastroenterology Source Type: research

Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019
ConclusionWe clarified the current status of CP in Japan. Further validation studies are warranted to clarify the diagnostic utility of DC2019. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - July 15, 2020 Category: Gastroenterology Source Type: research

The first management using intubation of a nasogastric tube with Gastrografin enterography or long tube for non-strangulated acute small bowel obstruction: a multicenter, randomized controlled trial
AbstractBackgroundGastrointestinal decompression is generally applied to a non-strangulated acute small bowel obstruction (NSASBO). Although long tube (LT) placement and administration of Gastrografin through a nasogastric tube (NGT-G) have shown advantages over NGT alone in previous studies, no studies appear to have compared LT and NGT-G.MethodsIn this multicenter, randomized controlled trial, patients with NSASBO were randomly assigned to receive LT or NGT-G between July 2016 and November 2018 at 11 Japanese institutions. The primary endpoint was non-inferiority of NGT-G compared to LT for non-surgery rate, and the lowe...
Source: Journal of Gastroenterology - July 14, 2020 Category: Gastroenterology Source Type: research