Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
ConclusionsThe quantitative measurement system for M2BPGi depends on liver fibrosis and inflammation, regardless of etiology. Liver inflammation complicates the interpretation of M2BPGi-Qt results when assessing the fibrosis stage. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Source Type: research
The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis
ConclusionsThe H-pattern exhibited greater necro-inflammation in the histology than the C-pattern, whereas the latter showed more cirrhosis. The accuracy of NITs in detecting fibrosis was decreased in H-pattern. The occurrence of decompensated events and mortality was predominant in C-pattern. Therefore, identifying MASLD phenotypes based on the biochemical presentation could be relevant for clinical practice. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Source Type: research
Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals
ConclusionsThe prevalence of MASLD decreased after achieving SVR12 with DAAs. Patients with pre-existing T2D showed a diminished probability of MASLD regression and a heightened risk of MASLD emergence post-SVR12. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 13, 2024 Category: Gastroenterology Source Type: research
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
ConclusionsNUDT15 codon 139 genotyping effectively reduces thiopurine-induced AEs and improves treatment retention rates in IBD patients after genotype-based dose adjustments. This study provides data-driven treatment strategies based on genotype and identifies risk factors for specific AEs, contributing to a refined thiopurine treatment approach. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 8, 2024 Category: Gastroenterology Source Type: research
Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma
ConclusionsCareful management is warranted for patients with risk factors for exacerbation of PH-related complications; moreover, the effective use of CECT is clinically important. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 7, 2024 Category: Gastroenterology Source Type: research
Natural history of lean and non-lean metabolic dysfunction-associated steatotic liver disease
ConclusionLean MASLD exhibits a similar LRE risk and a lower CVE risk to non-lean MASLD. Therefore, follow-up and treatment strategies should be tailored to the specific MASLD condition. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 4, 2024 Category: Gastroenterology Source Type: research
iATT liver fat quantification for steatosis grading by referring to MRI proton density fat fraction: a multicenter study
ConclusionsCompared to MRI-PDFF, iATT showed excellent diagnostic accuracy in grading steatosis. iATT could be used as a diagnostic tool instead of MRI in clinical practice and trials.Trial registration This study was registered in the UMIN Clinical Trials Registry (UMIN000047411). (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 30, 2024 Category: Gastroenterology Source Type: research
CACNA2D1 regulates the progression and influences the microenvironment of colon cancer
ConclusionsCACNA2D1 plays an important role in the progression and the microenvironment of CC by regulating fibroblasts and may act as a biomarker for disease progression and a therapeutic target for CC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 27, 2024 Category: Gastroenterology Source Type: research
Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.
ConclusionsBTR varies by sex and age even among healthy adults, and decreasing process and timing of BTR during disease progression is different among CLD etiologies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Source Type: research
