Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy
ConclusionsDifferential diagnosis of ELA and normal mucosa should be carefully performed to prevent misdiagnosis of ELA as normal mucosa with atypia. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 13, 2019 Category: Gastroenterology Source Type: research

Effects of proton pump inhibitor use on risk of Clostridium difficile infection: a hospital cohort study
ConclusionsOur study showed that PPI use was associated with an increased risk of developing CDI and the risk of CDI was dose dependent. Therefore, PPIs should only be used at proper doses and only for the necessary indications to avoid CDI risk. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 11, 2019 Category: Gastroenterology Source Type: research

What is causing the rising incidence of esophageal adenocarcinoma in the West and will it also happen in the East?
AbstractIn the West, the incidence of esophageal adenocarcinoma, which is a long-term complication of damage by gastroesophageal reflux, has been rising over recent decades. Two main factors are likely to account for this increase. The first is the rising incidence of central obesity which promotes gastroesophageal reflux. The second is the falling incidence ofH. pylori infection and associated atrophic gastritis which reduces the acidity and peptic activity of gastric juice, the main factors damaging to the esophageal mucosa. The rise in esophageal adenocarcinoma has been mirrored by a fall in gastric cancer consistent wi...
Source: Journal of Gastroenterology - June 6, 2019 Category: Gastroenterology Source Type: research

The course of elderly patients with persistent hepatitis C virus infection without hepatocellular carcinoma
ConclusionMost elderly HCV patients die from non-liver-related disease, especially those with less advanced liver fibrosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - June 3, 2019 Category: Gastroenterology Source Type: research

Nonalcoholic fatty liver disease is associated with lower hepatitis B viral load and antiviral response in pediatric population
ConclusionsAn inverse association between CBI and NAFLD reciprocally existed in pediatric population. In longitude study, HBsAg loss was associated with NAFLD at week 96 of antiviral therapy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 27, 2019 Category: Gastroenterology Source Type: research

Carcinoembryonic antigen level in the pancreatic juice is effective in malignancy diagnosis and prediction of future malignant transformation of intraductal papillary mucinous neoplasm of the pancreas
We examined the ability of diagnosing malignancy in 63 patients who underwent surgery (surgical group). Furthermore, we examined the value of predicting malignant transformation in 52 patients who underwent follow-up for over 1  year after ERP (follow-up group).ResultsIn the surgical group, the overall sensitivity and specificity of CEA level ( ≥ 97 ng/ml) in the pancreatic juice for diagnosing malignancy were 45% and 100%, respectively. The specificity was excellent for all IPMN types; however, the sensitivity was highest in main duct type, followed by mixed type and branch duct type. In the follow-up ...
Source: Journal of Gastroenterology - May 20, 2019 Category: Gastroenterology Source Type: research

Preceding endoscopic submucosal dissection for T1 colorectal carcinoma does not affect the prognosis of patients who underwent additional surgery: a large multicenter propensity score-matched analysis
ConclusionsPreceding ESD with histological en bloc resection for patients with T1 CRC did not affect their oncologic behavior adversely after additional surgery. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 18, 2019 Category: Gastroenterology Source Type: research

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey
ConclusionsIN-associated AEs were identified among patients with UC, with liver dysfunction often being reversible, while surgical resection was required in a high proportion of patients who developed intussusception. Both healthcare workers and patients should adequately recognize the potential for AEs with the use of IN. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 17, 2019 Category: Gastroenterology Source Type: research

Dose –response relationship between cigarette smoking and risk of ulcerative colitis: a nationwide population-based study
ConclusionsCompared with nonsmokers, former smokers have a significantly higher risk of UC development that may be proportional to the cumulative smoking exposure. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 15, 2019 Category: Gastroenterology Source Type: research

Impact of the Charlson Comorbidity Index on the treatment strategy and survival in elderly patients after non-curative endoscopic submucosal dissection for esophageal squamous cell carcinoma: a multicenter retrospective study
AbstractBackgroundIn elderly patients with superficial esophageal squamous cell carcinoma (ESCC), the optimal treatment strategy after non-curative endoscopic submucosal dissection (ESD) remains unclear. We aimed to evaluate the validity of additional treatments after non-curative ESD and post-ESD survival predictors in elderly patients with ESCC.MethodsElderly patients (age> 75 years) treated with ESD for ESCC between January 2010 and July 2014 at six tertiary referral hospitals in Japan were retrospectively investigated and stratified according to lymph node metastasis risk, based on histological findings (high-risk f...
Source: Journal of Gastroenterology - May 4, 2019 Category: Gastroenterology Source Type: research

Epitope peptides of Helicobacter pylori CagA antibodies from sera by whole-peptide mapping
ConclusionsOur results suggest that the amino acid sequences constituted in the two reactive peptides are the important immunogenic regions of CagA which would be useful to develop next-generation peptide-based diagnostic assays. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 2, 2019 Category: Gastroenterology Source Type: research

Withdrawal of thiopurines in Crohn ’s disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2)
ConclusionContinuation of thiopurines  >  6 months offers no clear benefit over scheduled ADA monotherapy. CFCR, ER, and ADA trough level at week 52 were not significantly different between groups. ER at week 0 may be involved in better long-term clinical outcomes. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 30, 2019 Category: Gastroenterology Source Type: research

Integrated analysis of circRNAs and mRNAs expression profile revealed the involvement of hsa_circ_0007919 in the pathogenesis of ulcerative colitis
ConclusionsSeveral circRNAs were differentially expressed in UC. Hsa_circ_0007919 is related to clinical characteristics and epithelial integrity by binding to hsa-let-7a, hsa-miR-138 to regulate the target genes. CircRNAs, especially hsa_circ_0007919, are associated with the pathogenesis and development of UC, with potential diagnostic and therapeutic implications. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer
ConclusionsApproximately, half of the patients with PD-L1 expression positive and almost all the patients with PD-L1 expression negative could be diagnosed on FNA specimens. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

Efficacy and safety of hangeshashinto for treatment of GERD refractory to proton pump inhibitors
AbstractBackgroundProton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) leads to a clinical decline in the quality of life (QOL). Therefore, new treatment options are needed. We performed a multicenter, randomized, parallel-group exploratory trial to determine the efficacy of hangeshashinto (HST) in patients with PPI-refractory GERD.MethodsWe enrolled 78 patients with PPI-refractory GERD for standard PPI regimens for at least 4  weeks and randomly assigned patients to receive either a combination of usual dose of rabeprazole (10 mg/day) + HST (7.5 g/day; HST group) or a ...
Source: Journal of Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

Is the new potent acid-inhibitory drug vonoprazan effective for healing idiopathic peptic ulcers? A multicenter observational study in Akita Prefecture, Japan
ConclusionsSix- or 8-week vonoprazan treatment still seems to be insufficient for healing IPUs. Longer-term vonoprazan or another treatment option may be required to heal potentially refractory peptic ulcers. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

Polyethylene glycol 3350 plus electrolytes for chronic constipation: a 2-week, randomized, double-blind, placebo-controlled study with a 52-week open-label extension
AbstractBackgroundAlthough polyethylene glycol 3350 plus electrolytes (PEG3350  + E) is the most widely used osmotic laxative in Europe, prospective data on its long-term (over 6 months) safety and efficacy are not available to date.MethodsJapanese patients with chronic constipation were randomized to receive PEG3350  + E or placebo for 2 weeks orally. Following this, the patients received PEG3350 + E in the 52-week extension study. The starting dose was 13.7 g/day dissolved in 125 mL of water, and dose titration was allowed (upper limit 41.1 g/day) accordi...
Source: Journal of Gastroenterology - April 22, 2019 Category: Gastroenterology Source Type: research

Management of elderly ulcerative colitis in Japan
AbstractJapan has the largest aging society, where many elderly people have intractable diseases including ulcerative colitis (UC). Along with the increasing total number of UC patients, the number of elderly UC patients has also been increasing and will continue to do so in the future. Although the clinical features and natural history of UC in the elderly have many similarities with UC in the non-elderly population, age-specific concerns including comorbidities, immunological dysfunction, and polypharmacy make the diagnosis and management of elderly UC challenging compared to UC in non-elderly patients. Based on increasi...
Source: Journal of Gastroenterology - April 20, 2019 Category: Gastroenterology Source Type: research

Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma
ConclusionEndogenous and exogenous BMP4 activate liver fibroblasts to gain capacity of secreting cytokines and enhancing invasiveness of cancer cells in the liver. BMP4 is one of the regulatory factors of CAFs functioning in the microenvironment of HCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 2, 2019 Category: Gastroenterology Source Type: research

Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis
AbstractBackgroundEsophageal motility abnormalities (EMAs) and interstitial lung diseases (ILDs) are often seen in patients with systemic sclerosis (SSc). Gastroesophageal reflux disease (GERD) could be associated with ILDs, but it is not fully understood if ILDs are caused by GERD or SSc itself.MethodsA total of 109 patients with SSc who underwent high-resolution manometry were enrolled. Esophageal motility was diagnosed with the Chicago classification v3.0. The severity of skin thickness was evaluated by the modified Rodnan total skin thickness score (mRSS). The severity of ILDs was assessed with the chest high-resolutio...
Source: Journal of Gastroenterology - April 1, 2019 Category: Gastroenterology Source Type: research

Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma
ConclusionsThe incidence of EAC and superficial EGJ adenocarcinoma with characteristics similar to those of EAC, including Barrett ’s adenocarcinoma, might be increasing. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 29, 2019 Category: Gastroenterology Source Type: research

Genetic variants in RPA1 associated with the response to oxaliplatin-based chemotherapy in colorectal cancer
ConclusionsOur findings demonstrate an association between rs5030740 and the DCR and PFS of colorectal cancer patients.RPA1 functions as a putative oncogene in tumorigenesis by reducing sensitivity to oxaliplatin and could serve as a potential prognostic biomarker in colorectal cancer. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 28, 2019 Category: Gastroenterology Source Type: research

A new era for understanding genetic evolution of multistep carcinogenesis
AbstractCancer development is a multistep process involving genetic and cellular alterations, and recent advances in next-generation sequencing have elucidated mutation landscapes of premalignant lesions as well as early- and late-stage tumors. In this issue of Journal of Gastroenterology, Kim and colleagues contributed to the better understanding of genetic events in putative precursors of hepatocellular carcinoma (HCC). Precancerous tissues are divided into canonical and non-canonical types, which share common driver mutations with cancerous lesions or not, and potential gatekeeper gene(s) for clonal selection play a cri...
Source: Journal of Gastroenterology - March 28, 2019 Category: Gastroenterology Source Type: research

Systematic review with network meta-analysis: indirect comparison of the efficacy of vonoprazan and proton-pump inhibitors for maintenance treatment of gastroesophageal reflux disease
ConclusionsThe efficacy of vonoprazan in GERD maintenance treatment may be higher than that of some PPIs. However, a direct comparison of vonoprazan and PPIs is required to confirm these effects. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 27, 2019 Category: Gastroenterology Source Type: research

Response to the letter by Sumida et al. regarding our manuscript “Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease”
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 26, 2019 Category: Gastroenterology Source Type: research

Is the grade of ballooned hepatocytes a significant risk factor for rapid progression of hepatic fibrosis in patients with NAFLD?
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 26, 2019 Category: Gastroenterology Source Type: research

Initial- and re-treatment effectiveness of glecaprevir and pibrentasvir for Japanese patients with chronic hepatitis C virus-genotype 1/2/3 infections
ConclusionsInitial and re-treatment with GLE/PIB are effective and safe for Japanese patients with HCV-1/2/3 in real-life settings. Further studies are required to elucidate the mechanism underlying treatment failures of GLE/PIB to completely eradicate HCV worldwide. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 22, 2019 Category: Gastroenterology Source Type: research

Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection
The objectives were to evaluate rate of sustained virologic response 12 weeks post-treatment (SVR12) and safety of the 8-week regimen in the ITT population.ResultsOverall, SVR12 was achieved by 98.9% (889/899) of DAA-na ïve patients without cirrhosis, including 99.2% (597/602) of GT1-infected and 98.3% (292/297) of GT2-infected patients. Less than 1% (2/899) of patients overall and no Japanese patients experienced virologic failure. SVR12 rate was>  97% for patients regardless of baseline characteristics, and common comorbidities or co-medications. Overall,
Source: Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Source Type: research

A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms
This study aimed to elucidate whether the three NE markers such as chromogranin A, synaptophysin, and NCAM decide prognoses for patients with well-differentiated tumors.MethodsBetween April 2002 and October 2018, 217 patients were included in this study. Tissue samples from tumors of Pan-NENs were immunochemically stained for the aforementioned NE markers. Diffuse and intense staining was defined as positive, while faint or focal staining and non-staining were considered negative.ResultsThe median age of patients was 55  years. The median observation period was 1415 days. In multivariate analysis of progression-f...
Source: Journal of Gastroenterology - March 12, 2019 Category: Gastroenterology Source Type: research

Correction to: Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study
In the original publication of this article, Tables 2, 3, 4, 5 and 6 were published incorrectly. The correct tables are given below. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 11, 2019 Category: Gastroenterology Source Type: research

Meaningless comparison of resection depth between cold snare polypectomy and endoscopic mucosal resection
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Response to the letter by Matsushita et al. regarding our manuscript “Resection Depth and Layer of Cold Snare Polypectomy versus Endoscopic Mucosal Resection”
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 9, 2019 Category: Gastroenterology Source Type: research

Real-world virological efficacy and safety of daclatasvir/asunaprevir/beclabuvir in patients with chronic hepatitis C virus genotype 1 infection in Japan
ConclusionsMany patients treated with the DCV/ASV/BCV regimen have a history of a failure to achieve SVR with previous IFN-free DAA therapy. SVR rate was not as high as that in pre-approval clinical trial of this regimen in IFN-free DAA-na ïve patients. In addition, most patients with a history of failure with IFN-free DAA therapy, particularly the DCV/ASV regimen, showed resistance to this regimen. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 8, 2019 Category: Gastroenterology Source Type: research

Noninvasive diagnostic criteria for nonalcoholic steatohepatitis based on gene expression levels in peripheral blood mononuclear cells
ConclusionsExpression levels of the cytokine- and chemokine-encoding genes in PBMCs were positively correlated with ballooning, suggesting their utility for the diagnosis of NASH. The data indicate that peripheral as well as intrahepatic immunity is involved in the progression of NASH. Our findings afford new insight into immunological mechanisms of NASH and will facilitate its noninvasive diagnosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 4, 2019 Category: Gastroenterology Source Type: research

Epstein –Barr virus status is a promising biomarker for endoscopic resection in early gastric cancer: proposal of a novel therapeutic strategy
AbstractBackgroundEpstein –Barr virus-positive gastric cancer (EBVGC) is associated with a low prevalence of lymph node metastasis (LNM); however, EBV status is not considered in the indication of endoscopic resection (ER). We aimed to clarify the implication of EBV status for ER of pT1b GC.MethodsConsecutive cases of pT1b GCs treated with surgery between 2005 and 2014 were retrospectively analyzed. Clinicopathological factors and LNM status were compared between EBVGC and non-EBVGC groups.ResultsEBVGC accounted for 7.9% (71 of 898) cases. Compared to non-EBVGC, EBVGC was more frequent in males (p  =  0...
Source: Journal of Gastroenterology - March 2, 2019 Category: Gastroenterology Source Type: research

YAP and the Hippo pathway in cholangiocarcinoma
AbstractCholangiocarcinoma (CCA) has an increasing incidence and remains a difficult to treat malignancy. In a search for more effective treatment options, progress has been made in identifying molecular drivers of oncogenic signaling including IDH mutations and FGFR2 fusions. In addition, multiple investigators have identified increased activity of YAP, the effector protein of the Hippo pathway, in CCA. The Hippo pathway regulates organ size, cellular proliferation, and apoptosis via YAP, a transcriptional co-activator. Targeting of the pathway has been difficult due the lack of a dedicated cell-surface receptor. However,...
Source: Journal of Gastroenterology - February 27, 2019 Category: Gastroenterology Source Type: research

Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions
ConclusionsRectal tumor location, depression, protuberance within the depression, expansiveness, and loss of mucosal patterns could be predictive factors for HRC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 27, 2019 Category: Gastroenterology Source Type: research

Recent advancement in EUS-guided fine needle sampling
AbstractEUS-guided tissue acquisition technique plays an essential role for evaluation of gastrointestinal tumors. Several components affect the yield of EUS-guided tissue acquisition outcomes such as sampling techniques, use of ROSE (rapid onsite evaluation), training and experience, and needle designs. In this review we discuss advancement in EUS-guided fine needle sampling. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 26, 2019 Category: Gastroenterology Source Type: research

Efficacy and safety of glecaprevir and pibrentasvir treatment for 8 or 12  weeks in patients with recurrent hepatitis C after liver transplantation: a Japanese multicenter experience
ConclusionsEight- or 12-week regimen of glecaprevir and pibrentasvir is efficacious and safe in patients with recurrent HCV infection after liver transplantation, even in difficult-to-treat populations, including patients with severe renal impairment, prior DAA experience, liver cirrhosis, or jaundice after liver transplantation. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 26, 2019 Category: Gastroenterology Source Type: research

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice
ConclusionSeveral differences in gene expression with respect to HBV genotype A and C infection were detected in human hepatocytes. These differences might be associated with genotypic difference in the clinical course or responsiveness to treatment. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 21, 2019 Category: Gastroenterology Source Type: research

Cost-effectiveness analysis of lenvatinib treatment for patients with unresectable hepatocellular carcinoma (uHCC) compared with sorafenib in Japan
ConclusionsLenvatinib was cost-effective compared with sorafenib for the first-line treatment of uHCC in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 20, 2019 Category: Gastroenterology Source Type: research

Safety and efficacy of glecaprevir and pibrentasvir in Japanese hemodialysis patients with genotype 2 hepatitis C virus infection
ConclusionsAn 8- or 12-week G/P regimen is highly effective and safe in GT2 HCV-infected hemodialysis patients. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 18, 2019 Category: Gastroenterology Source Type: research

A Helicobacter pylor i screening and treatment program to eliminate gastric cancer among junior high school students in Saga Prefecture: a preliminary report
AbstractBackgroundTo present the strategies and preliminary findings of the first 3  years after implementing aHelicobacter pylori screening and eradication program to prevent gastric cancer in Saga Prefecture.MethodsA screening and treatment program to eradicateH. pylori from third-grade junior high students was started in Saga Prefecture in 2016, using local governmental grants. Screening was with urinary anti-H. pylori antibody tests, followed byH. pylori stool antigen tests for students who were antibody positive. Those positive on both tests underwentH. pylori eradication by triple therapy based on a potassium-co...
Source: Journal of Gastroenterology - February 15, 2019 Category: Gastroenterology Source Type: research

Metachronous gastric cancer risk after endoscopic resection of early gastric cancer and H. pylori status
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 15, 2019 Category: Gastroenterology Source Type: research

Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center
AbstractOver almost 30  years since functional dyspepsia (FD) was defined, researchers have endeavored to elucidate the pathophysiology of functional gastrointestinal disorders. Now a consensus is emerging that the gastric symptoms of FD are caused mainly by gastric motility abnormalities and gastric hypersensitivity. Th e involvement of other causative factors including acid,Helicobacter pylori, psychological factors, and diet has been debated, but how they are involved in the manifestation of dyspeptic symptoms remains unclear. We believe that most of those factors cause FD symptoms by inducing gastric motility abno...
Source: Journal of Gastroenterology - February 14, 2019 Category: Gastroenterology Source Type: research

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis
ConclusionAnalyses of RNs constructing cirrhotic liver indicated that a variety of genetic aberrations accumulate in the cirrhotic liver before the development of clinically and histologically overt HCC. These aberrations in RNs could provide the basis of tumorigenesis in patients with liver cirrhosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 12, 2019 Category: Gastroenterology Source Type: research

Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma
ConclusionsThese findings suggest the potential usefulness of THC and its combination with NQO1 inhibitor as a therapeutic option for ESCC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 8, 2019 Category: Gastroenterology Source Type: research

Serum aldo –keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis
ConclusionAKR1B10 is a useful serum biomarker for advanced liver fibrosis in NASH and, combined with serum WFA(+)-M2BP, can predict HCC development, gastroesophageal varix formation, and poor prognosis. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 1, 2019 Category: Gastroenterology Source Type: research

Acknowledgements
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 30, 2019 Category: Gastroenterology Source Type: research

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice
ConclusionTherapies combining at least two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents may be effective for HCV-infected patients with NS5A-P32del. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 25, 2019 Category: Gastroenterology Source Type: research