Trajectories of glycaemia following acute pancreatitis: a prospective longitudinal cohort study with 24  months follow-up
AbstractBackgroundNew-onset diabetes is the most common sequela of acute pancreatitis (AP). Yet, prospective changes in glycaemia over time have never been investigated comprehensively in this study population. The primary aim was to determine the cumulative incidence of new-onset prediabetes and new-onset diabetes after AP over 24  months of follow-up in a prospective cohort study. The secondary aim was to identify trajectories of glycaemia during follow-up and their predictors at the time of hospitalisation.MethodsPatients with a prospective diagnosis of AP and no diabetes based on the American Diabetes Association ...
Source: Journal of Gastroenterology - June 3, 2020 Category: Gastroenterology Source Type: research

Confounding factors of non-invasive tests for nonalcoholic fatty liver disease
AbstractNonalcoholic fatty liver disease (NAFLD) affects at least 25% of the general adult population worldwide. Because only a fraction of the patients would develop liver-related complications, it is preferable to perform non-invasive tests as the initial assessment. This review summarizes the known and potential confounding factors that affect the performance of non-invasive tests of hepatic steatosis and fibrosis in patients with NAFLD. Clinicians may apply the knowledge and exercise caution in selecting investigations and interpreting test results when confounding factors are present. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 25, 2020 Category: Gastroenterology Source Type: research

Real-world effectiveness and safety of tolvaptan in liver cirrhosis patients with hepatic edema: results from a post-marketing surveillance study (START study)
ConclusionsThe results suggest that tolvaptan was effective and well-tolerated in liver cirrhosis patients with hepatic edema. In the real-world clinical setting, tolvaptan provides a useful option for the treatment of hepatic edema. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 9, 2020 Category: Gastroenterology Source Type: research

Evidence-based diagnosis and clinical practice guidelines for intestinal Beh çet’s disease 2020 edited by Intractable Diseases, the Health and Labour Sciences Research Grants
AbstractBeh çet's disease (BD) is an intractable systemic inflammatory disease characterized by four main symptoms: oral and genital ulcers and ocular and cutaneous involvement. The Japanese diagnostic criteria of BD classify intestinal BD as a specific disease type. Volcano-shaped ulcers in the ileocecum are a typical finding of intestinal BD, and punched-out ulcers can be observed in the intestine or esophagus. Tumor necrosis factor inhibitors were first approved for the treatment of intestinal BD in Japan and have been used as standard therapy. In 2007 and 2014, the Japan consensus statement for the d iagnosis an...
Source: Journal of Gastroenterology - May 7, 2020 Category: Gastroenterology Source Type: research

Interleukin-35 promotes the differentiation of regulatory T cells and suppresses Th2 response in IgG4-related type 1 autoimmune pancreatitis
ConclusionsThis study identified elevated expression of plasma IL-35 and tissue IL-35 subunits in patients with type 1 AIP. This might lead to inflammation suppression via activated eTregs. IL-35 might be associated with this anti-inflammatory role, especially against the Th2 response through several cytokines and the differentiation of Tregs in type 1 AIP. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 6, 2020 Category: Gastroenterology Source Type: research

Defining the  phenotype, pathogenesis and treatment of Crohn’s disease associated spondyloarthritis
AbstractPeripheral and axial spondyloarthritis are the most common extra-intestinal manifestations reported in patients with Crohn ’s disease. Despite the frequency of Crohn’s disease associated spondyloarthritis, clinical diagnostic tools are variably applied in these cohorts and further characterization with validated spondyloarthritis disease activity indexes are needed. In addition, the pathogenesis of Crohn’s diseas e associated spondyloarthritis is not well understood. Evidence of shared genetic, cellular, and microbial mechanisms underlying both Crohn’s disease and spondyloarthritis...
Source: Journal of Gastroenterology - May 4, 2020 Category: Gastroenterology Source Type: research

Nonalcoholic fatty liver disease: impact on healthcare resource utilization, liver transplantation and mortality in a large, integrated healthcare system
ConclusionsWithin a large, integrated healthcare system a diagnosis of NAFLD is independently associated with a 17% overall excess in HRU and a several-fold increase liver transplantation and mortality. Although the dollar amounts will change over time and between healthcare systems, the proportional need for HRU will have broad applicability and implications. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 23, 2020 Category: Gastroenterology Source Type: research

Correction to: Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradication therapy
In the original publication of the article, the article title was published with typo. The word “eradiation” should be “eradication” in the article title and keywords. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 19, 2020 Category: Gastroenterology Source Type: research

Paradox of age-specific incidence rates of second primary cancer in individuals with esophageal cancer
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 13, 2020 Category: Gastroenterology Source Type: research

Prevalence and risk factors for lymph node metastasis after noncurative endoscopic resection for early gastric cancer: a systematic review and meta-analysis
ConclusionsSeveral pathological factors, most notably lymphatic invasion and LVI, were associated with LNM in patients with noncurative resection after ER for EGC. Lymphatic and vascular invasion should be assessed separately instead of LVI (PROSPERO CRD42018109996). (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 10, 2020 Category: Gastroenterology Source Type: research

Longitudinal association of fatty pancreas with the incidence of type-2 diabetes in lean individuals: a 6-year computed tomography-based cohort study
AbstractBackgroundOnly a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort study, we investigated the association between fatty pancreas and T2D incidence in lean individuals.MethodsBetween 2008 and 2013, 1478 nondiabetic lean individuals (i.e. body-mass index  
Source: Journal of Gastroenterology - April 3, 2020 Category: Gastroenterology Source Type: research

Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities
AbstractPrimary sclerosing cholangitis (PSC) is a progressive liver disease, histologically characterized by inflammation and fibrosis of the bile ducts, and clinically leading to multi-focal biliary strictures and with time cirrhosis and liver failure. Patients bear a significant risk of cholangiocarcinoma and colorectal cancer, and frequently have concomitant inflammatory bowel disease and autoimmune disease manifestations. To date, no medical therapy has proven significant impact on clinical outcomes and most patients ultimately need liver transplantation. Several treatment strategies have failed in the past and whilst ...
Source: Journal of Gastroenterology - March 28, 2020 Category: Gastroenterology Source Type: research

Adverse events of nucleos(t)ide analogues for chronic hepatitis B: a systematic review
In conclusion, treatment of CHB with NAs is safe, with a low incidence of AEs. Despite the general understanding TAF being safer than TDF, the number of patients treated with TAF still is too small in comparison to other NAs to consolidate an accurate safety profile. PROSPERO Registration No. CRD42018086471 (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 17, 2020 Category: Gastroenterology Source Type: research

Objective evaluation for treat to target in Crohn ’s disease
ConclusionsProper optimization is necessary in clinical practice. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 4, 2020 Category: Gastroenterology Source Type: research

Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies
AbstractBackgroundLiver injury induced by immune checkpoint inhibitors (ICIs) is an immune-related adverse event (irAE) whose incidence has increased with the broader use of ICIs in clinical practice. However, the incidental risk factors of immune-related liver injury are unknown. We investigated the clinical characteristics of immune-related liver injury.MethodsA total of 546 patients treated with ICIs for advanced malignancies between September 2014 and February 2019 were included retrospectively. Factors associated with immune-related liver injury were determined.ResultsImmune-related liver injury ( ≥ Grade 3)...
Source: Journal of Gastroenterology - March 2, 2020 Category: Gastroenterology Source Type: research

Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients
ConclusionsThe analysis of PBMCs in NAFLD patients showed that T-cell profiles were different from those of HVs. And, it suggested that fatty acids modified T-cell profiles and were involved in liver fibrosis in NAFLD patients. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 2, 2020 Category: Gastroenterology Source Type: research

Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial
ConclusionsRamucirumab after prior sorafenib improved PFS and OS compared with placebo, with a manageable safety profile, in the Japanese REACH-2 subpopulation, consistent with the overall REACH-2 study results. Ramucirumab is the first agent to demonstrate clinical benefit for Japanese patients with HCC in the second-line setting. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 27, 2020 Category: Gastroenterology Source Type: research

JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study
ConclusionsIn HCV GT1- and GT2-infected Japanese patients, treatment with JNJ-4178 was well tolerated and resulted in 100% of patients achieving SVR12. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 17, 2020 Category: Gastroenterology Source Type: research

Response to the letter by Lai et al. regarding our manuscript “Statin use and pancreatic cancer risk in two prospective cohort studies”
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 14, 2020 Category: Gastroenterology Source Type: research

Clinicopathological and molecular correlations in traditional serrated adenoma
ConclusionsOur observations indicate that TSAs mostly harbor various combinations of concurrent WNT and MAPK gene alterations. The associations between genetic and morphological features suggest that the histological diversity of TSA reflects the underlying molecular heterogeneity. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 12, 2020 Category: Gastroenterology Source Type: research

Statins and pancreatic cancer risk
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 8, 2020 Category: Gastroenterology Source Type: research

How long should patients be surveyed for gastric cancer risk after Helicobacter pylori eradication therapy? 10  years is no longer enough
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - February 5, 2020 Category: Gastroenterology Source Type: research

Unresolved issues of immune tolerance in chronic hepatitis B
AbstractDuring the natural course of chronic hepatitis B virus infection, immune-tolerant phase is characterized by high viral replication, the presence of HBV e antigen (HBeAg), and normal or minimally elevated serum alanine aminotransferase. Immune-tolerant phase is usually regarded as a benign course of the disease. International guidelines recommend observation rather than treatment during immune-tolerant phase. In this article, we review unresolved issues related to the definition of true immune-tolerant phase and the benefit of antiviral treatment. Defining true immune-tolerant phase requires a careful approach and l...
Source: Journal of Gastroenterology - February 3, 2020 Category: Gastroenterology Source Type: research

Correction to: Magnitude and direction of the association between Clostridium difficile infection and proton pump inhibitors in adults and pediatric patients: a systematic review and meta-analysis
In the original publication of the article, Table 1 and Figs. 2a, 2b, 3a were published with errors. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 30, 2020 Category: Gastroenterology Source Type: research

Recent advances in chemotherapy for pancreatic cancer: evidence from Japan and recommendations in guidelines
AbstractThe prognosis of patients with pancreatic cancer continues to remain dismal, even though numerous trials have been conducted to establish more effective therapies in Japan and throughout the world. Recent advances in treatment have been characterized by the use of novel combinations of conventional cytotoxic chemotherapies. Especially in Japan, S-1 has become one of the most widely used cytotoxic agents for the treatment of pancreatic cancer, after clinical evidence was established of the survival benefit offered by this drug for patients with resectable or unresectable pancreatic cancer. Unfortunately, with the ex...
Source: Journal of Gastroenterology - January 29, 2020 Category: Gastroenterology Source Type: research

A nationwide, multi-center, retrospective study of symptomatic small bowel stricture in patients with Crohn ’s disease
AbstractBackgroundSmall bowel stricture is one of the most common complications in patients with Crohn ’s disease (CD). Endoscopic balloon dilatation (EBD) is a minimally invasive treatment intended to avoid surgery; however, whether EBD prevents subsequent surgery remains unclear. We aimed to reveal the factors contributing to surgery in patients with small bowel stricture and the factors associat ed with subsequent surgery after initial EBD.MethodsData were retrospectively collected from surgically untreated CD patients who developed symptomatic small bowel stricture after 2008 when the use of balloon-assisted ente...
Source: Journal of Gastroenterology - January 27, 2020 Category: Gastroenterology Source Type: research

Antibodies to Crohn ’s disease peptide 353 as a diagnostic marker for pediatric Crohn’s disease: a prospective multicenter study in Japan
AbstractBackgroundVarious serologic markers such as anti-glycoprotein 2 antibodies and anti-Saccharomyces cerevisiae antibodies have been reported to be diagnostically useful in Crohn ’s disease. Mitsuyama et al. reported that antibodies to Crohn’s disease peptide 353, a newly proposed serologic marker, were more useful in Japanese adults than anti-Saccharomyces. We addressed the same issue in Japanese children and adolescents.MethodsProspectively enrolled subjects under 17  years old assessed and treated at 12 pediatric centers in Japan included groups with Crohn’s disease, ulcerative colitis, other...
Source: Journal of Gastroenterology - January 24, 2020 Category: Gastroenterology Source Type: research

Emerging therapies for PBC
AbstractPrimary biliary cholangitis is an uncommon cholestatic liver disease predominantly affecting middle-aged women. Left untreated, there is a high risk of progression to end-stage liver disease. Few treatment options exist. To date, ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are the only medical therapies approved for use, other than symptomatic treatments and liver transplantation, the latter of which is reserved for those developing complications of cirrhosis or with intractable pruritus. UDCA improves outcomes, but many patients do not adequately respond. OCA therapy may improve response, but long-term ...
Source: Journal of Gastroenterology - January 22, 2020 Category: Gastroenterology Source Type: research

Acknowledgements
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 22, 2020 Category: Gastroenterology Source Type: research

Can portal hypertension and hepatic decompensation be predicted?
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 21, 2020 Category: Gastroenterology Source Type: research

Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis
ConclusionsThese findings suggest that the IRF7-IFN-I-IL-33 axis activated in pDCs drives pathogenic innate immune responses associated with type 1 AIP. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 20, 2020 Category: Gastroenterology Source Type: research

An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort
AbstractBackgroundContemporary primary sclerosing cholangitis (PSC) population-based cohorts describing the epidemiology, natural history, and long-term fluctuations in serum alkaline phosphatase (SAP) and their prognostic relevance are lacking. Therefore, we investigated the incidence and natural history of PSC and quantified SAP fluctuations among those with PSC in Olmsted County, Minnesota over the last 41  years.MethodsThe Rochester Epidemiology Project was used to identify 56 subjects diagnosed with PSC between 1976 and 2017 in Olmsted County. The primary endpoint (n = 19) included liver transplanta...
Source: Journal of Gastroenterology - January 13, 2020 Category: Gastroenterology Source Type: research

Sodium absorption stimulator prostasin (PRSS8) has an anti-inflammatory effect via downregulation of TLR4 signaling in inflammatory bowel disease
ConclusionProstasin has an anti-inflammatory effect via downregulation of TLR4 expression in colonic epithelial cells. Reduced prostasin expression in IBD mucosa is linked to the deterioration of local anti-inflammatory activity and may contribute to the persistence of mucosal inflammation. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 8, 2020 Category: Gastroenterology Source Type: research

Multi-regional sequencing reveals clonal and polyclonal seeding from primary tumor to metastases in advanced gastric cancer
ConclusionsClonal mutations were maintained at both the primary and metastatic sites and genetic divergence of these was low. These findings shed light on the genetic basis of primary tumor dissemination and metastatic processes in advanced gastric cancer. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - January 7, 2020 Category: Gastroenterology Source Type: research

Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016
ConclusionWe clarified the current status of AIP in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 23, 2019 Category: Gastroenterology Source Type: research

Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review
AbstractRecent advances in small-bowel endoscopy such as capsule endoscopy have shown that non-steroidal anti-inflammatory drugs (NSAIDs) frequently damage the small intestine, with the prevalence rate of mucosal breaks of around 50% in chronic users. A significant proportion of patients with NSAIDs-induced enteropathy are asymptomatic, but some patients develop symptomatic or complicated ulcers that need therapeutic intervention. Both inhibition of prostaglandins due to the inhibition of cyclooxygenases and mitochondrial dysfunction secondary to the topical effect of NSAIDs play a crucial role in the early process of inju...
Source: Journal of Gastroenterology - December 21, 2019 Category: Gastroenterology Source Type: research

Comparison of prognosis between observation and surgical resection groups with small sporadic non-functional pancreatic neuroendocrine neoplasms without distant metastasis
ConclusionsThe prognosis of small localized PNENs is good. Observation may be an alternative to surgery in high-risk patients and those with small G1 tumors, particularly those measuring  ≤ 1 cm. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 19, 2019 Category: Gastroenterology Source Type: research

Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives
AbstractNon-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of dysregulated lipid and glucose metabolism, which is often associated with obesity, dyslipidemia and insulin resistance. In view of the high morbidity and health risks of NAFLD, the lack of effective cure has drawn great attention. In recent years, a line of evidence has suggested a close linkage between the intestine and liver diseases such as NAFLD. We summarized the composition and characteristics of intestinal microbes and reviewed molecular insights into the intestinal microbiome in development and progression of NAFLD. Intestinal microbe...
Source: Journal of Gastroenterology - December 16, 2019 Category: Gastroenterology Source Type: research

Effects of vedolizumab in Japanese patients with Crohn ’s disease: a prospective, multicenter, randomized, placebo-controlled Phase 3 trial with exploratory analyses
ConclusionVedolizumab showed a numerically greater efficacy versus placebo as induction therapy, but the difference was not statistically significant. Vedolizumab also showed a numerically greater efficacy in maintenance therapy, and was well tolerated. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 13, 2019 Category: Gastroenterology Source Type: research

The von Willebrand Factor antigen to platelet ratio (VITRO) score predicts hepatic decompensation and mortality in cirrhosis
AbstractBackgroundThe ratio of von Willebrand Factor to platelets (VITRO) reflects the severity of fibrosis and portal hypertension and might thus hold prognostic value.MethodsPatients with compensated cirrhosis were recruited. VITRO, Child –Pugh score (CPS) and MELD were determined at study entry. Hepatic decompensation was defined as variceal bleeding, ascites or hepatic encephalopathy. Liver transplantation and death were recorded.ResultsOne hundred and ninety-four patients with compensated cirrhosis (CPS-A 89%, B 11%; 56% male; median age 56  years; 50% with varices) were included. During a median follow-up ...
Source: Journal of Gastroenterology - December 12, 2019 Category: Gastroenterology Source Type: research

Correction to: Risk of gastric cancer in the second decade of follow-up after Helicobacter pylori eradication
In the original publication of the article, the figure  3 was published with errors. The corrected figure 3 should appear as in this correction. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 9, 2019 Category: Gastroenterology Source Type: research

High incidence of head and neck cancers after endoscopic resection for esophageal cancer in younger patients
This study included patients who underwent endoscopic resection for superficial EC at our hospital between September 1994 and September 2011. Patients ’ data, including sex, age at diagnosis, sequence of cancer incidence, cancer histology, and cancer site, were extracted from the cancer registry.ResultsOf 544 patients, 255 developed second cancers. Simultaneous head and neck cancers (HNCs) and other organ cancers (OCs) were, respectively, present in 15% (80/544) and 9.6% (52/544) of patients; and 30% (162/544) developed metachronous second cancers over a median follow-up period of 79.5  months (range 2–120...
Source: Journal of Gastroenterology - December 7, 2019 Category: Gastroenterology Source Type: research

Long-term proton pump inhibitor usage and the association with pancreatic cancer in Sweden
ConclusionsThis large study showed an increased risk of pancreatic cancer in long-term users of PPIs in Sweden, in particular among the youngest users. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 6, 2019 Category: Gastroenterology Source Type: research

Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial
ConclusionsApheresis was well tolerated as maintenance therapy for UC although the cumulative clinical remission rate at 12  months was comparable between the apheresis and control groups. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - December 6, 2019 Category: Gastroenterology Source Type: research

Abdominal obesity increases risk for esophageal cancer: a nationwide population-based cohort study of South Korea
AbstractBackgroundThe relationship between overall obesity, as measured by body mass index (BMI) and risk of esophageal squamous cell carcinoma (ESCC) has been reported to show a negative correlation. However, the relationship of ESCC, which accounts for around 90% of esophageal cancers in South Korea, with abdominal obesity, as measured by waist circumference (WC), may be different. Thus, we investigated the association between abdominal obesity and esophageal cancer in a nationwide population-based cohort.MethodsA retrospective cohort study of 22,809,722 individuals who had undergone regular health check-ups provided by ...
Source: Journal of Gastroenterology - December 2, 2019 Category: Gastroenterology Source Type: research

Is metabolic syndrome responsible for the progression from NAFLD to NASH in non-obese patients?
(Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 28, 2019 Category: Gastroenterology Source Type: research

Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay
ConclusionsWe report the development of a screening system that is useful for identifying non-nucleos(t)ide RT inhibitors. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 25, 2019 Category: Gastroenterology Source Type: research

Transition in the etiology of liver cirrhosis in Japan: a nationwide survey
ConclusionsHCV has remained the main cause of LC in Japan; however, the contribution of viral hepatitis as an etiology of LC is suggested to have been decreasing. In addition, non-viral LC, such as ALD-related LC and NASH-related LC, is suggested to have increased as etiologies of LC in Japan. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 25, 2019 Category: Gastroenterology Source Type: research

Correction to: High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype
The correct name of the last author should be. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 25, 2019 Category: Gastroenterology Source Type: research

Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial
ConclusionsCRAI with NM did not inhibit the development of pancreatic necrosis although early analgesic effect of CRAI was superior to that of IV. Less-invasive IV therapy can be considered a viable alternative to CRAI therapy. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 22, 2019 Category: Gastroenterology Source Type: research