[Is dissection of the facial nerve avoidable during surgery for benign parotid tumors? : Parotid surgery without facial nerve dissection].
Authors: Mantsopoulos K, Bär B, Iro H PMID: 32060568 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 17, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[ORATOR study : Surgery or radiotherapy for oropharyngeal carcinoma in the context of HPV?]
Authors: Hoffmann TK PMID: 32060569 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 17, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[IgG4-Related Orbitopathy as an Important Differential Diagnosis of Advanced Silent Sinus Syndrome. German version].
We report the case of a patient referred to us after multiple unsuccessful paranasal sinus operations who presented with enophthalmos and a resultant migratory keratitis with a suspected diagnosis of silent sinus syndrome. Preservation of the orbit was no longer feasible. After five years without a definitive diagnosis, we ascertained that this was a case of IgG4-related disease. DISCUSSION: IgG4-related disease represents an important element in the differential diagnosis of chronic advanced diseases of the orbit and paranasal sinuses. The diagnosis should be considered in the case of unclear ...
Source: HNO - February 17, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Immunosuppression and Immunotherapy in Cancer : International symposium at the Ulm University Hospital].
Authors: Hoffmann TK PMID: 32047977 [PubMed - in process] (Source: HNO)
Source: HNO - February 14, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Geriatric assessment-evidence and application in otorhinolaryngology].
CONCLUSION: This article provides an overview of the most important instruments of geriatric assessment, including a discussion of their potential applicability in otorhinolaryngology. PMID: 32052072 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 14, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Dementia: relevant aspects for otorhinolaryngologists].
Authors: Dodel R, Völter C Abstract The aging of society observed during the past century in industrialized countries has not only led to a longer life expectancy, but also an increased frequency of age-related diseases and multimorbidity. In addition to dysphagia and vertigo, sensory deficits such as olfaction and hearing disorders are common in elderly persons and have a significant influence on quality of life. Alzheimer's disease is the most common form of dementia. Epidemiological studies have recently shown that disorders of olfaction and hearing are not only associated with dementia, but also represent ...
Source: HNO - February 8, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Complications of cosmetic piercings and tattoos in the head and neck region].
Authors: Hackenberg B, Große-Büning S, Hammes S, Strieth S Abstract Piercings and tattoos have gained popularity across all cultural environments during the past century, and one in ten Europeans are now pierced. While tattoos are often restricted to the rest of the body, piercings are common at facial sites such as ears, nose, lips, and tongue. Complications following piercings are not uncommon. Infections can rapidly spread across the auricular cartilage and require antibiotic and often surgical treatment. Mild trauma (i.e., piercing the earlobe) can lead to excessive scar formation due to fibroblast p...
Source: HNO - February 7, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Possibilities and limitations of palliative surgery in head and neck cancer patients].
CONCLUSION: Especially in the palliative setting, patients and their individual complaints are the primary focus. Therefore, the indications for surgery should be discussed with the patient and his relatives, preferentially interdisciplinarily. Due to considerable progress, particularly in the field of systemic tumor therapy, extended surgical procedures with reconstruction are losing some of their importance in the palliative situation. PMID: 32016529 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 6, 2020 Category: ENT & OMF Tags: HNO Source Type: research

Targeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids.
Authors: Ferrone S, Whiteside TL Abstract This manuscript describes the functional properties of the exosomes released from melanoma cells. It details the characteristics of the tumor antigen chondroitin sulfate proteoglycan 4 (CSPG4), which is used as a marker to separate exosomes released by melanoma cells from exosomes released by nonmalignant cells. The results are discussed in view of the potential role of melanoma cell-derived exosomes in the escape of malignant cells from the host's immune system. PMID: 32006045 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 3, 2020 Category: ENT & OMF Tags: HNO Source Type: research

Immunotherapeutics for head and neck squamous cell carcinoma stem cells.
Authors: Qian X, Leonard F, Wenhao Y, Sudhoff H, Hoffmann TK, Ferrone S, Kaufmann AM, Albers AE Abstract Cancer stem cell (CSC)-related therapy resistance has become a new obstacle to the successful application of cancer treatment and head and neck squamous cell carcinoma (HNSCC) is no exception to this finding. Head and neck squamous cell carcinoma is highly immune-suppressive, and recently the immune suppression and invasion of HNSCC-CSCs have been characterized. These characteristics have received research and clinical attention because they would enable the stratification of patients into specific cancer s...
Source: HNO - February 1, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Medical examination: Preparation for ENT specialisation : Part  46].
[Medical examination: Preparation for ENT specialisation : Part 46]. HNO. 2020 Jan 29;: Authors: Hofauer B, Heiser C, Offergeld C PMID: 31996934 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 1, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Exosomes: Nanodust? German version].
Authors: Muller L Abstract Until recently, exosomes were considered to be dust in electron microscopy. This perception has changed dramatically in the past few years. A new research field has emerged aiming to describe the formation, release, and function of these nanoparticles. The role of exosomes evolved from garbage bins to biologically active, selectively secreted particles that are part of a novel and broader messaging system. They were shown to display immunomodulatory properties. Today, exosomes are regarded as attractive targets for diagnostic and therapeutic purposes, especially in the field of ...
Source: HNO - February 1, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Allergo-oncology: what allergologists and oncologists can learn from each other : Regulatory T  cells in allergy and cancer].
CONCLUSION: Regulatory T cells play an important role in the pathogenesis of cancer and allergies, and thus represent a therapeutic target. PMID: 31970443 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 25, 2020 Category: ENT & OMF Tags: HNO Source Type: research

Exosomes: nanodust?
Authors: Muller L Abstract Until recently, exosomes were considered to be dust in electron microscopy. This perception has changed dramatically in the past few years. A new research field has emerged aiming to describe the formation, release, and function of these nanoparticles. The role of exosomes evolved from garbage bins to biologically active, selectively secreted particles that are part of a novel and broader messaging system. They were shown to display immunomodulatory properties. Today, exosomes are regarded as attractive targets for diagnostic and therapeutic purposes, especially in the field of ...
Source: HNO - January 25, 2020 Category: ENT & OMF Tags: HNO Source Type: research

Is the number of tonsillectomies and tonsillotomies a  relevant issue?
This study was conducted to quantify and analyze both types of tonsil surgery in Germany. METHODS: Data from the Federal Office of Statistics on the number of procedures and population size were used to calculate annual intervention rates between 2005 and 2017. Percentual changes in intervention rates compared to the previous year were calculated for Germany, for the total number of ENT specialists, for the ENT specialists of the federal states, and for four age groups (≤10; ≤20; ≤40;>40 years). RESULTS: Regression analysis revealed a significant decrease in (adeno)tonsillectomy and a signific...
Source: HNO - January 25, 2020 Category: ENT & OMF Tags: HNO Source Type: research

A  treatise on endothelial biology and exosomes: homage to Theresa Maria Listowska Whiteside.
A treatise on endothelial biology and exosomes: homage to Theresa Maria Listowska Whiteside. HNO. 2020 Jan 21;: Authors: Ludwig N, Lotze MT Abstract Exosomes are the current primary research focus of Dr. Theresa L. Whiteside. They are key mediators of intercellular communication in the head and neck, as well as other sites. Their effects in the tumor microenvironment are manifold and include suppression of immunity, promotion of angiogenesis, enabling of metastasis, as well as reprogramming of fibroblasts and mesenchymal stromal cells. The aim of this communication is to summarize Dr. Whitesi...
Source: HNO - January 24, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Angiolytic laser applications for the larynx : Phonosurgical concepts for transoral laser microsurgery].
Authors: Strieth S, Hagemann J, Hess M Abstract Transoral laser microsurgery (TLM) for treatment of laryngeal cancer has reduced temporary tracheotomies, increased organ preservation rates, and improved functional results. Gold standard for laser-based transoral resection of laryngeal cancer is the application of CO2 lasers. Oncologically safe radical resection and postoperative voice outcome must be weighed up individually. Angiolytic laser effects enable modification of the tumor micromilieu by targeted obliteration of microvessels and antagonization of angiogenesis with preservation of vibrating laryngeal tissue...
Source: HNO - January 18, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Exosomes: potential liquid biopsy in head and neck cancer].
In conclusion, the presented studies can make an essential contribution to the establishment of exosomes as liquid biopsies for head and neck cancer diagnosis and treatment monitoring. PMID: 31915880 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 11, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Comparison of T cell response in the tumor milieu of patients with HPV+ and HPV- head and neck cancer].
CONCLUSION: The importance of the adaptive immune response for treatment response and patients' prognosis has been supported by different investigations. Understanding the immunological processes in the tumor environment plays an important role for the development of new treatment approaches. PMID: 31915881 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 11, 2020 Category: ENT & OMF Tags: HNO Source Type: research

Adenosine production in mesenchymal stromal cells in relation to their developmental status.
CONCLUSION: Mesenchymal stromal cells are potent producers of ADO and are, therefore, able to increase immunosuppression. As MSC differentiate into chondrocytes, they lose this ability and may take on other functions. PMID: 31915882 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 11, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Study protocol of the monocentric prospective randomized placebo-controlled double-blind phase  II study to explore the protective effects of the ginkgo biloba extract EGb 761® from temporary noise-induced hearing loss].
CONCLUSION: This summary of the verification study protocol highlights the complexity of diligent and precise planning according to the European Medicines Agency criteria for controlled trials (EudraCT). Key points are the intervention rationale, definitions of in- and exclusion criteria, estimation of subject numbers, and examination method setting in terms of optimum endpoint description. PMID: 31915883 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 11, 2020 Category: ENT & OMF Tags: HNO Source Type: research

IgG4-related orbitopathy as an important differential diagnosis of advanced silent sinus syndrome.
We report the case of a patient referred to us after multiple unsuccessful paranasal sinus operations who presented with enophthalmos and a resultant migratory keratitis with a suspected diagnosis of silent sinus syndrome. Preservation of the orbit was no longer feasible. After five years without a definitive diagnosis, we ascertained that this was a case of IgG4-related disease. DISCUSSION: IgG4-related disease represents an important element in the differential diagnosis of chronic advanced diseases of the orbit and paranasal sinuses. The diagnosis should be considered in the case of unclear ...
Source: HNO - January 11, 2020 Category: ENT & OMF Tags: HNO Source Type: research

The new Mainz speech test for children 3-7  years old (MATCH) : Design, standardization, and validation.
The new Mainz speech test for children 3-7 years old (MATCH) : Design, standardization, and validation. HNO. 2020 Jan 08;: Authors: Schirkonyer V, Keilmann A, Harmuth C, Wachtlin B, Rader T, Bohnert A Abstract OBJECTIVE: To develop a new, German, age-appropriate speech audiometry test for children, by using 26 nouns that are most likely part of the lexicon of 2-year-olds. The test is a picture-pointing task with a four-option non-forced choice method. MATERIALS AND METHODS: In total, 179 children aged 2;11 to 6;9 y were included for standardizing and validating the speech test. Of these, ...
Source: HNO - January 11, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Head and neck cancer in the elderly-current aspects].
CONCLUSION: Pretreatment risk stratification of geriatric patients with head and neck malignancies is of high relevance for the individual decision for or against invasive treatment, but the currently available evidence is limited. This paper is based on a systematic literature review and provides a clinical algorithm for otorhinolaryngologists and head and neck surgeons. PMID: 31912168 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 9, 2020 Category: ENT & OMF Tags: HNO Source Type: research

[Patient orientation of websites of otorhinolaryngologists in private practice in Bavaria].
CONCLUSION: The results exhibit an inadequate use of criteria catalogues for web presence. A patient-oriented website configuration could help to improve customer acquisition and satisfaction, which is particularly relevant for cities with a high density of physicians. PMID: 31853577 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 21, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Is the number of tonsillectomies and tonsillotomies a  relevant issue? German version].
This study was conducted to quantify and analyze both types of tonsil surgery in Germany. METHODS: Data from the Federal Office of Statistics on the number of procedures and population size were used to calculate annual intervention rates between 2005 and 2017. Percentual changes in intervention rates compared to the previous year were calculated for Germany, for the total number of ENT specialists, for the ENT specialists of the federal states, and for four age groups (≤10; ≤20; ≤40;>40 years). RESULTS: Regression analysis revealed a significant decrease in (adeno)tonsillectomy and a signific...
Source: HNO - December 19, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Dank an die Gutachter 2019.
Authors: PMID: 31796998 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 6, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Tonsil surgery in the federal states of Germany: similarities and differences.
CONCLUSION: The change of trends in tonsil surgery started long before relevant national guidelines were published. The national trend was associated with considerably less surgical activity overall, a significant decrease in ATE/TE, and a significant increase in TT. Regional differences to the national trend were identified and found to be significant in at least in 7 of 16 federal states. PMID: 31796999 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 6, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Structured oral examination ("guided questions") as a  method for objectifying the ENT specialist examination in Germany].
[Structured oral examination ("guided questions") as a method for objectifying the ENT specialist examination in Germany]. HNO. 2019 Nov 29;: Authors: Eichhorn T, Guntinas-Lichius O, Jungehülsing M, Neudert M Abstract On behalf of the federal Ministries of Health, the various German medical associations organize and conduct the board certification examinations for becoming an ENT specialist at the end of residency. The oral examination comprises a collegial discussion that should last at least 30 min and which rarely exceeds 45 to 60 min in practice. The current article de...
Source: HNO - December 2, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[The new Mainz speech test for children aged 3-7  years (MATCH) : Design, standardization, and validation. German version].
[The new Mainz speech test for children aged 3-7 years (MATCH) : Design, standardization, and validation. German version]. HNO. 2019 Nov 28;: Authors: Schirkonyer V, Keilmann A, Harmuth C, Wachtlin B, Rader T, Bohnert A Abstract OBJECTIVE: A new German speech audiometry test was developed using 26 nouns that are most likely part of the lexicon of 2‑year-old children. The test was a picture-pointing task using a four-alternative non-forced choice method. MATERIALS AND METHODS: In total, 179 children aged 2 years 11 months to 6 years 9 months were includ...
Source: HNO - December 1, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Overview on research in the field of medical education].
Authors: Wijnen-Meijer M, Gartmeier M, Berberat PO Abstract Medical education is a relatively young field of research that has been characterized by many innovations over the last 20 years. The main topics were the preparation of students for their medical work and imparting of profound knowledge about scientific contexts in medicine. For a long time, the main focus was on learning the necessary knowledge and skills; however, this is no longer considered sufficient. In order to carry out the work as a physician well, other qualities are also necessary, such as communication, collaboration, profe...
Source: HNO - November 29, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Nasennebenh öhlen/Rhinobasis.
Nasennebenhöhlen/Rhinobasis. HNO. 2019 Dec;67(12):894-895 Authors: PMID: 31768583 [PubMed - in process] (Source: HNO)
Source: HNO - November 28, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Oncologic treatment concepts for head and neck cancer : Important results from the world's largest cancer congress, 2019].
Authors: Hoffmann TK PMID: 31768584 [PubMed - in process] (Source: HNO)
Source: HNO - November 28, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Erratum zu: Charakterisierung eines geschlossenen Logatomtests : Erhebung audiometrischer Kenndaten: Diskriminationsfunktion und Reproduzierbarkeit.
Authors: Hörmann L, Ambrosch P, Hey M PMID: 31768609 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 28, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Bilateral intracochlear schwannomas in a  patient with no genetic or clinical features of neurofibromatosis type 2. German version].
This report describes the first case of bilateral sporadic intracochlear schwannomas in a patient with no genetic or clinical features of NF2. PMID: 31758201 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 25, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Pretesting of the German Vocal Fatigue Index (VFI-D)-transcultural translation and cross validation].
CONCLUSION: The first German version of the VFI‑D might be a base for further research on symptoms, causes, and treatment options in vocal fatigue. Particularly patients in voice-intensive professions may benefit. PMID: 31754731 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 23, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Speech recognition with hearing aids for 10  standard audiograms].
CONCLUSION: The expectation regarding hearing aid provision has to be adjusted according to maximum word recognition score, the derived quality measures, degree of hearing loss, and audiogram type. PMID: 31728573 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 16, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Tips for training assistants on preparing and conducting their board certification examination].
This article first discusses the general requirements for conducting board certification examinations as laid down in the specialty training regulations of the German State Chambers of Physicians. Concrete suggestions are made for training assistants concerning selection of the specialist literature to be processed and allocation of the time in which the material to be covered can be learned. Aspiring medical specialists are provided with suggestions regarding their surroundings and a favorable atmosphere in the final hours before the examination. Furthermore, desirable but also undesirable behaviors of the examinee during...
Source: HNO - November 15, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Tonsil surgery in the federal states of Germany: similarities and differences. German version].
CONCLUSION: The change of trends in tonsil surgery started long before relevant national guidelines were published. The national trend was associated with considerably less surgical activity overall, a significant decrease in ATE/TE, and a significant increase in TT. Regional differences to the national trend were identified and found to be significant in at least in 7 of 16 federal states. PMID: 31720695 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 15, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Laryngectomy-still state of the art?]
Authors: Vahl JM, Schuler PJ, Greve J, Laban S, Knopf A, Hoffmann TK Abstract Total laryngectomy provides a curative approach for patients with advanced laryngeal and hypopharyngeal cancer without distant metastasis. Especially in stage cT4a disease, laryngectomy is superior to primary radio(chemo)therapy in retrospective studies. Further relevant indications for the procedure are tumor-related laryngeal dysfunction such as dysphagia and aspiration, as well as cancer recurrence after primary radio(chemo)therapy. The surgical procedure is highly standardized, with an appropriate safety profile. The subsequent l...
Source: HNO - November 15, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Active hearing implants in chronic otitis media].
Authors: Lailach S, Müller C, Lasurashvili N, Seidler H, Zahnert T Abstract In patients with inadequate hearing improvement after tympanoplasty and failure of conventional hearing aid fitting, active hearing implants provide an alternative treatment option. Active middle ear implants function as a vibromechanical bypass of the stiffness and damping effect of a poorly oscillating tympanic membrane and the (reconstructed) ossicular chain. The selection of the hearing system depends on the maximum output levels of the hearing system and the anatomical conditions in mostly multiply operated ears. The development o...
Source: HNO - November 13, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Hospitalization of children after ENT surgery in Germany].
CONCLUSION: There is currently no uniform hospitalization strategy for postoperative care of children who undergo typical otorhinolaryngologic interventions in Germany. PMID: 31712876 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 13, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Extranodal manifestation of classical Hodgkin lymphoma in the head and neck region].
CONCLUSION: An exclusively extranodal manifestation of cHL in Waldeyer's ring is rare, whereas infiltration of extranodal tissue in the case of a primary manifestation of lymphoma in cervical nodes can occur more frequently and may often remain undiagnosed. Therefore, a specialized ENT consultation could be a reasonable complementary module in tumor staging to determine the correct tumor extent. PMID: 31712877 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 13, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Medical examination: preparation for ENT specialisation : Part  45].
[Medical examination: preparation for ENT specialisation : Part 45]. HNO. 2019 Nov 12;: Authors: Shiraliyev K, Offergeld C PMID: 31713646 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 13, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Influence of single-sided deafness on the auditory capacity of the better ear.
CONCLUSION: The origin of the poorer hearing of the better-hearing ear of SSD patients compared to an age-correlated NH cohort is still unclear. It is most likely a combination of different anatomical, immunological, etiological, and microcirculatory causes, which lead to poorer hearing of the better-hearing ear in SSD patients. PMID: 31705300 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 12, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Physical audiological principles of implantable hearing systems : About power transmission, coupling and power output].
Authors: Rahne T Abstract Implantable hearing systems work because mechanical vibration energy is introduced into the hearing system. The performance of the hearing system is thus essentially determined by physical parameters. Together with the tone and speech audiogram the indications for deciding on a system are based on the efficacy of the respective system and the patient's wishes. Hearing-assisted patients should have a dynamic range of 30-35 dB to adequately understand speech. This should be guaranteed with the respective system also in the medium to long term. In addition, sufficient cochlear reserve perfo...
Source: HNO - November 12, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Update on HPV-associated head and neck cancer-highlights from the 2019 ASCO Annual Meeting].
Authors: Tribius S, Würdemann N, Laban S, Hoffmann TK, Sharma SJ, Klussmann JP Abstract At this year's Annual Meeting of the American Society for Clinical Oncology (ASCO), the keyword search "HPV-associated head and neck cancer" resulted in 920 hits-74% of the hits on human papillomavirus (HPV). This underlines the relevance of the topic. The spectrum ranged from validation and separation of the prognostic groups of patients with HPV-associated oropharyngeal carcinoma (OPSCC) according to TNM 8, to the characterization of new tumor markers and tumor mutational burden for possible de-escalation s...
Source: HNO - November 11, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Treatment of head and neck squamous cell carcinoma recurrences and distant metastases : Highlights of the 2019 ASCO Meeting].
CONCLUSION: Based on the results of Keynote-048, pembrolizumab ± chemotherapy gained FDA approval as first-line treatment for R/M-HNSCC in the USA. Approval in Europe is expected soon and will probably have a strong impact on clinical routine. PMID: 31701170 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 11, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Characterization of a closed-set logatome test : Documentation of audiometric data: discrimination function and reproducibility].
CONCLUSION: The slope of the discrimination function at the SRT appeared to be shallow but was comparable to established word tests. Finally, there was no evidence of a learning effect in the retest, which emphasizes the low redundancy of the speech material and makes it an attractive complementary option to routine audiometric diagnostics. PMID: 31690970 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 8, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Implantierbare H örsysteme.
Implantierbare Hörsysteme. HNO. 2019 Nov;67(11):816-817 Authors: Stöver T PMID: 31673745 [PubMed - in process] (Source: HNO)
Source: HNO - November 2, 2019 Category: ENT & OMF Tags: HNO Source Type: research