[Schirmer test for determining the moisture status of the nasal mucosa].
Authors: Stupp F, Weigel A, Hoffmann TK, Sommer F, Grossi AS, Lindemann J Abstract BACKGROUND: There is no established method to objectively measure the moisture status of nasal mucosa. In a pilot study it was shown that a nasal Schirmer test is a possible method. The aim of the current study was to check whether the nasal Schirmer test is suitable to define moisture status in cases with an expected pathological secretion. MATERIALS AND METHODS: Initially, 154 subjects participated, of whom n = 112 were included (healthy n = 65, deviated septum n = 47, ♂ 60, ♀&...
Source: HNO - February 22, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Hearing interventions to prevent dementia.
Authors: Dawes P Abstract Hearing loss is a marker of risk for cognitive decline and dementia. Controlled hearing intervention studies of long-term cognitive outcomes are challenging, and thus the evidence for the impact of hearing interventions is primarily from observational studies and will likely continue to be from studies other than randomised controlled trials. Seven studies of hearing interventions with cognitive outcomes assessed over longer than 3 years are reviewed. Most were of low-to-moderate quality. One cochlear implant study had indeterminate findings. Of six hearing aid studies, thre...
Source: HNO - February 17, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Quality of life after functional aesthetic septorhinoplasty].
Authors: Gassner HG Abstract PMID: 30767055 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 17, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Negative effects of stripe conchotomy on intranasal conditioning].
CONCLUSION: Partial resection of the caudal part of the inferior turbinate may lead to disturbed intranasal conditioning of inspired air if performed too radically. Therefore, if possible, this procedure should be avoided and a more gentle mucosal procedure chosen. PMID: 30767056 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 17, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Selected ENT symptoms in functional disorders of the upper cervical spine and temporomandibular joints.
Authors: Hölzl M, Behrmann R, Biesinger E, von Heymann W, Hülse R, Goessler UR, Arens C Abstract This paper discusses otorhinolaryngological symptoms associated with functional disorders of the upper cervical spine. Hints aimed to avoid misdiagnoses of cross-organ otorhinolaryngological symptoms as phobic or psychogenic disorders are presented. Clinically relevant neuroanatomical convergence of the upper cervical spine (occiput to C3) is fundamental for the interpretation of functional otorhinolaryngological symptoms. Based thereon, evidence for the most common cervical differential diagnoses of dizziness...
Source: HNO - February 13, 2019 Category: ENT & OMF Tags: HNO Source Type: research

The speed limit of outer hair cell electromechanical activity.
Authors: Santos-Sacchi J Abstract The outer hair cell of Corti's organ provides mechanical feedback into the organ to boost auditory perception. The fidelity of voltage-dependent motility has been estimated to extend beyond 50 kHz, where its force generation is deemed a requirement for sensitive high-frequency mammalian hearing. Recent investigations have shown, however, that the frequency response is substantially more low pass at physiological membrane potentials where the kinetics of prestin impose their speed limit. Nevertheless, it is likely that the reduced magnitude of electromotility is sufficient to...
Source: HNO - February 13, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[The subjective perception of the vertical-a valuable parameter for determination of peripheral vestibular disorder in Meni ère's disease in the chronic phase?]
[The subjective perception of the vertical-a valuable parameter for determination of peripheral vestibular disorder in Menière's disease in the chronic phase?] HNO. 2019 Feb 06;: Authors: Voß LJ, Zabaneh SI, Hölzl M, Olze H, Stölzel K Abstract The perception of verticality is mainly based on utricular afferent signals and central processing of the transmitted signals. However, there are also extracranial receptors that make a considerable contribution to the perception of verticality. With the subjective visual vertical (SVV) for the utricle and the subjective trunk vertical...
Source: HNO - February 7, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Diagnostics and treatment of olfactory dysfunction].
CONCLUSION: Since a 50% decrease in the prevalence of olfactory disturbances is unlikely, the lower patient numbers may relate to a more critical diagnosis. The use of olfactory training in clinics has increased significantly (from
Source: HNO - February 7, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Introduction to the new article type "technical comment"].
[Introduction to the new article type "technical comment"]. HNO. 2019 Feb;67(2):82 Authors: Plontke SK Abstract PMID: 30725154 [PubMed - in process] (Source: HNO)
Source: HNO - February 7, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Hot Topic: Schilddr üse.
Hot Topic: Schilddrüse. HNO. 2019 Feb;67(2):80-81 Authors: Abstract PMID: 30725155 [PubMed - in process] (Source: HNO)
Source: HNO - February 7, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Models of tinnitus development : From cochlea to cortex].
Authors: Krauss P, Schilling A, Tziridis K, Schulze H Abstract The development of subjective tinnitus is still not mechanistically understood and existing models are controversially discussed. In this overview, the authors discuss three of the main models, all of which propose damage to the cochlea as the initial step in tinnitus development. Based on these models, a possible manifestation of tinnitus-related neuronal activity at the perceptually relevant level of the auditory pathway, the auditory cortex, is presented. Furthermore, it is demonstrated that one of the models offers a new view on the phenom...
Source: HNO - February 3, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Tinnitus: psychosomatic aspects].
Authors: Boecking B, Brueggemann P, Mazurek B Abstract Tinnitus is a common symptom of unclear origin that can be multifactorially caused and maintained. It is frequently, but not inevitably, associated with hearing loss. Emotional distress and maladaptive coping strategies - that are associated with or amplified by the tinnitus percept - pose key targets for psychological interventions. Once somatic contributors are identified and treated as applicable, psychological approaches comprise normalizing psychoeducational and psychotherapeutic interventions. Measures to improve hearing perception (e. g., hea...
Source: HNO - January 31, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Perspectives of genome editing in otorhinolaryngology].
CONCLUSIONS: In theory, genome editing could be used in otolaryngology to target disease-causing genomic loci specifically. However, various challenges have to be overcome until applications can be used clinically. PMID: 30689007 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 30, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Medical examination: Preparation for ENT specialisation : Part  40].
[Medical examination: Preparation for ENT specialisation : Part 40]. HNO. 2019 Jan 17;: Authors: Offergeld C, Shiraliyev K, Arndt S, Aschendorff A Abstract PMID: 30656351 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 20, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Comparison of piezoelectric and conventional osteotomy in rhinoplasty : A  systematic review].
CONCLUSION: Piezoelectric osteotomy resulted in a reduced propensity for postoperative edema and ecchymosis compared to the conventional osteotomy technique with a chisel. At this time, the results should be regarded as a trend. A definite recommendation favoring piezoelectric osteotomy cannot be made until more studies with higher patient numbers become available. PMID: 30649568 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 18, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Endoskopie und Bildgebung.
Authors: Abstract PMID: 30645683 [PubMed - in process] (Source: HNO)
Source: HNO - January 17, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Immuno-oncology of head and neck tumors].
Authors: Kasper S, Hussain T, Virchow I, Stuschke M, Lang S Abstract Treatment of patients with squamous cell carcinoma of the head and neck (SCCHN) is nowadays multidisciplinary. Therapeutic concepts include modern surgical and radiation techniques as well as systemic therapies. However, the prognosis of these patients is still poor for all stages. In the recurrent or metastatic situation after definitive therapy, there is an indication for palliative systemic treatment, whereby classical platinum-based chemotherapy and the monoclonal epidermal growth factor receptor (EGFR) antibody cetuximab are established, and ...
Source: HNO - January 14, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Maximum monosyllabic score as a  predictor for cochlear implant outcome].
CONCLUSION: The preoperatively measured PBmax may be used as a predictor for the minimum speech perception obtained with CI. This is of high clinical relevance for CI candidates with a PBmax above zero. PMID: 30635677 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 14, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Neck dissection-Surgical treatment of cervical lymphatic drainage pathways].
Authors: Vahl JM, Hoffmann TK Abstract Neck dissection (ND) is an essential component of treatment in head and neck squamous cell carcinoma (HNSCC). The extent of ND depends on primary tumor location and T and N stage. Trials have demonstrated improved survival for cN+ status with therapeutic ND as well as for cN0 status with selective ND if the primary has a high incidence of occult metastasis. The accuracy of the procedure is of prognostic relevance. In the prognostic model of the TNM classification, the parameter "N" does not only reflect the number of affected lymph nodes, but also thei...
Source: HNO - January 10, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Reasons for the development of allergies in children].
Authors: Klimek L, Wollenberg B, Guntinas-Lichius O, Pfaar O, Koennecke M Abstract Allergies are one of the most common chronic diseases in childhood, contributing to a tremendous medical and economical burden in health care systems of most industrialized countries. The development of allergies is dependent on a complex interaction of-among others-environmental factors, nutrition, genetic and epigenetic mechanisms as well as the microbiome. These diverse factors can influence early life immune regulation including innate and adaptive immune mechanisms in a complex fashion. In case of any Childhood al...
Source: HNO - January 5, 2019 Category: ENT & OMF Tags: HNO Source Type: research

[Guideline: Auditive Processing and Perception Disorders: Definition : Guideline of the German Society of Phoniatrics and Pediatric Audiology].
Authors: Ptok M, Kiese-Himmel C, Nickisch A Abstract In accordance with international consensus papers, Auditory Processing Disorders are defined here as disorders of central processes of hearing, which enable, among other things, the pre-conscious and conscious analysis, differentiation, and identification of changes in time, frequency, and intensity of acoustic or auditory speech signals as well as processes of binaural interaction (e. g., for localization, lateralization, noise clearance, and summation) and dichotic processing. Following the establishment of a commission of experts from the German Society...
Source: HNO - December 15, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Dank an die Gutachter 2018.
Authors: PMID: 30539197 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 14, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Complications and complication management in rhinology].
Authors: Beule AG Abstract PMID: 30506313 [PubMed - in process] (Source: HNO)
Source: HNO - December 8, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Innenohrschwerh örigkeit, Tinnitus.
Innenohrschwerhörigkeit, Tinnitus. HNO. 2018 Jun;66(6):416-417 Authors: PMID: 30506314 [PubMed - in process] (Source: HNO)
Source: HNO - December 8, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[The adaptive Freiburg monosyllabic test in noise : Development of a  procedure and comparison of the results with the Oldenburg sentence test].
CONCLUSION: The Freiburg monosyllabic test can not only be used for quantifying discrimination loss in percentage terms, but also to measure the 50% speech recognition threshold with an adaptive algorithm. However, the procedure of the adaptive Freiburg monosyllabic test is more time consuming than that of the Oldenburg sentence test. Concerning a possible missing correlation between the results for 50% speech discrimination, further studies with hearing-impaired persons are needed. PMID: 30519714 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 8, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Erratum to: Management of acute vertigo and dizziness : Patients in emergency departments in Germany].
Authors: Löhler J, Eßer D, Wollenberg B, Walther LE Abstract PMID: 30506084 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Report from the 12th  Congress of the European Laryngological Society : London, 16-19 May 2018].
[Report from the 12th Congress of the European Laryngological Society : London, 16-19 May 2018]. HNO. 2018 Nov 27;: Authors: Sittel C Abstract PMID: 30483828 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - December 1, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Current treatment concepts in head and neck cancer : Highlights of the 2018 ASCO meeting].
Authors: Hoffmann TK Abstract PMID: 30488090 [PubMed - in process] (Source: HNO)
Source: HNO - December 1, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Implantierbare H örsysteme.
Implantierbare Hörsysteme. HNO. 2018 Dec;66(12):876-877 Authors: Abstract PMID: 30488091 [PubMed - in process] (Source: HNO)
Source: HNO - December 1, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Obituary for Prof. Dr. med. Henning Bier (1957-2018) : Director of the Otorhinolaryngology Department at the Klinikum rechts der Isar of the Technical University of Munich from 2007 to 2018].
Authors: Hoffmann T Abstract PMID: 30478675 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 28, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Histology of adenoids].
Authors: Schrom T Abstract PMID: 30478676 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 28, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[The right thing to do with airmiles].
Authors: Wienke A, Wienke M Abstract PMID: 30465165 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 24, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Radiotherapeutic studies of head and neck cancer-highlights of the 2018 ASCO Annual Meeting].
CONCLUSION: The data presented do not justify a change of current treatment paradigms just yet. However, interesting developments can be expected in the coming years, particularly in the field of immunotherapy. PMID: 30421001 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 15, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Functional rehabilitation of severe laryngopharyngeal injuries after near-lethal suicide attempt by hanging].
CONCLUSION: Minimal external clinical findings after near-lethal suicide attempts by hanging do not exclude severe internal injuries of the upper aerodigestive tract structures. After reconstructive surgery an appropriate tracheal cannula management and an early and intensive swallowing therapy parallel to the psychiatric treatment is mandatory to restore voice, airway and deglutition. PMID: 30406269 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 9, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Anteromedial maxillectomy for improvement of nasal breathing : Advanced procedure in surgery of the lateral nasal wall].
This article presents an operative approach developed stepwise a few years ago in which the different operative steps are carried out depending on the individual anatomical situation and the underlying mucosal disease. The focus is on partial anteromedial maxillectomy. PMID: 30406270 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 9, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Sonographic analysis of swallowing in the cervical section of the esophagus].
Authors: Grebe LS, Wolf G, Schick B Abstract BACKGROUND: Dysphagia is a common symptom reported by patients in various medical fields, raising the question of diagnosis. In addition to otorhinolaryngologic examination with a mirror, the current gold standards videofluoroscopy and fiber optic endoscopic evaluation of swallowing (FEES) are available. Ultrasound is frequently used in everyday clinical practice, although its application for swallowing diagnostics needs addressing. MATERIALS AND METHODS: Between April 2012 and February 2014, 81 subjects (age 19-66 years) with no indication of a s...
Source: HNO - November 8, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[New aspects in thyroid cancer treatment : Highlights of the ASCO Annual Meeting 2018].
Authors: Möckelmann N, Münscher A Abstract Whereas surgical treatment of thyroid carcinoma plays an important role especially in the early stages, a multimodal approach is pursued in the palliative setting, which, in addition to classical chemotherapy primarily involves treatment with tyrosine kinase inhibitors. An analysis of clinical trials and studies presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2018 is presented. In particular, studies on the treatment of radioiodine-refractory differentiated thyroid cancer, anaplastic thyroid cancer and immunotherapy were selected...
Source: HNO - November 8, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Immunotherapy highlights of the ASCO annual meeting 2018 for head and neck cancers].
CONCLUSION: The role of immunotherapy for the treatment of head and neck cancer is markedly increasing. Many pioneering trials are currently ongoing, in the phase of data analysis or in planning. PMID: 30402813 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 8, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Alternative therapy practitioners-current information on a "difficult" occupational image].
[Alternative therapy practitioners-current information on a "difficult" occupational image]. HNO. 2018 Oct 30;: Authors: Wienke A, Wienke M Abstract PMID: 30377742 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Treatment of head and neck squamous cell carcinoma recurrences and distant metastases : Highlights of the 2018 ASCO meeting].
Authors: Bußmann L, Münscher A, Busch CJ Abstract This year, the treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC) was mainly dominated by immunotherapy. The corresponding studies are presented in another article. Beside this, results of phase II studies in particular were presented at the ASCO Annual Meeting, in which-as in recent years-new drugs (monoclonal antibodies, small molecules) played a major role. Furthermore, a clinical scoring system for prognosis evaluation in R/M-HNSCC patients was presented and the influence of HPV status on sur...
Source: HNO - November 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Hybrid prosthesis for vascular reconstruction of the internal carotid artery near the skull base after radical excision of a  very rare malignant glomus caroticum paraganglioma].
CONCLUSION: Extended resections, if necessary including vascular (arterial) segments, aim at achieving R0 classification as shown in this extremely rare and usually challenging malignant tumor. Hybrid vascular prostheses are suitable for time-saving vascular reconstruction (>50%) to provide sufficient blood supply. PMID: 30377744 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Vestibul äre Störungen.
Vestibuläre Störungen. HNO. 2018 Nov;66(11):798-799 Authors: Abstract PMID: 30382317 [PubMed - in process] (Source: HNO)
Source: HNO - November 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Entitlement to treatment with a  cochlear implant].
[Entitlement to treatment with a cochlear implant]. HNO. 2018 Oct 29;: Authors: Wienke A Abstract PMID: 30374626 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - November 1, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Clarifications on the topic of data protection].
Authors: Wienke A Abstract PMID: 30367218 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - October 29, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[How would you decide? : Ten questions and answers on patient disclosure].
Authors: Wienke A Abstract PMID: 30367219 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - October 29, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Who does my implant belong to? : A contribution to questions that everybody asks but no one can really answer].
Authors: Wienke A Abstract PMID: 30367220 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - October 29, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Don't be frightened of the "bad wolf" : The new EU general data protection regulation in hospitals and medical practices].
[Don't be frightened of the "bad wolf" : The new EU general data protection regulation in hospitals and medical practices]. HNO. 2018 Oct 26;: Authors: Friese KV, Wienke A Abstract PMID: 30367221 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - October 29, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Unusual tumor of the skull base with expansion into the soft tissues of the neck].
Authors: Jurkov M, Jecker P, Olze H, Knopke S Abstract PMID: 30361929 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - October 28, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[HPV-positive oropharyngeal cancer-risk for the partner?]
Authors: Vahl JM, Hoffmann TK Abstract A case of HPV-positive, metachronous oropharyngeal cancer in a married couple has been reported in the context of other studies, thus raising the question of whether it is necessary to screen or intensively monitor the partners of patients with HPV-positive oropharyngeal cancer, or whether preventive methods are required. Current data suggests that there is a potential risk for the partner to develop a concordant disease, but because of the lack of consolidated data, no statement on the frequency of this event can presently be made. Further epidemiological ...
Source: HNO - October 26, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Update on HPV-associated head and neck cancer-highlights of the 2018 ASCO Annual Meeting].
Authors: Tribius S, Würdemann N, Laban S, Sharma SJ, Wagner S, Hoffmann TK, Wittekindt C, Klussmann JP Abstract Rising incidence rates in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) and a significantly improved prognosis have brought this entity into scientific focus. At this year's American Society of Clinical Oncology (ASCO) Annual Meeting, 291 studies with the keyword "HPV" were presented, the majority of which were in head and neck cancer. Due to high rates of late toxicities after conventional therapy, de-intensified treatment concepts are being ...
Source: HNO - October 25, 2018 Category: ENT & OMF Tags: HNO Source Type: research