Difficult-to-treat chronic rhinosinusitis-when the  standard treatment is not effective and biologics are not available
CONCLUSION: To accurately assess the efficacy of second-line therapies for treatment of difficult-to-treat CRS within an endotype-specific framework, additional controlled clinical trials are needed that take into account the heterogeneity of CRS endotypes.PMID:38472346 | DOI:10.1007/s00106-024-01443-w (Source: HNO)
Source: HNO - March 13, 2024 Category: ENT & OMF Authors: Robert B öscke Source Type: research

Biologic therapy in patients with severe NSAID-exacerbated respiratory disease and previous aspirin desensitization : Results of a multicentric study
CONCLUSION: Add-on biologic therapy is effective, safe, and widely accepted among CRSwNP + NERD patients. Future studies might allow for personalized algorithms with sequential surgery, ATAD, and/or biologic therapy.PMID:38466409 | DOI:10.1007/s00106-024-01433-y (Source: HNO)
Source: HNO - March 11, 2024 Category: ENT & OMF Authors: Anna-Rebekka Staufenberg Hanna K Frankenberger Ulrike F örster-Ruhrmann Franziska C Spahn Ludger Klimek Kai Fruth Clemens Stihl Christoph Matthias Moritz Gr öger Jan Hagemann Source Type: research

Medical examination: Preparation for ENT specialisation : Part  71
HNO. 2024 Mar 6. doi: 10.1007/s00106-024-01439-6. Online ahead of print.NO ABSTRACTPMID:38448664 | DOI:10.1007/s00106-024-01439-6 (Source: HNO)
Source: HNO - March 6, 2024 Category: ENT & OMF Authors: M Plath K Plath Source Type: research

Eosinophils in otorhinolaryngology: friend or foe?
This article summarizes the essential aspects of current knowledge about eosinophils, classifies eosinophilia in terms of the dimensions healthy or harmful reaction, takes a specific look at eosinophils in the field of otorhinolaryngology, and gives recommendations for diagnostic workup and therapeutic intervention in case of proven eosinophilia, particularly as an adverse drug reaction. The thoughts are inspired by communications at the 29th Congress of the European Rhinologic Society in Sofia, Bulgaria, 2023.PMID:38436705 | DOI:10.1007/s00106-024-01442-x (Source: HNO)
Source: HNO - March 4, 2024 Category: ENT & OMF Authors: Martin Laudien Source Type: research

Increasing incidence of mastoidectomies in children : Result of reduced antibiotic therapy or late COVID-19 sequela?
CONCLUSION: No clear correlation with reduced outpatient antibiotic therapy could be found. Whether there exists an association with prior COVID infection cannot be judged at this time, due to the high number of asymptomatic and therefore unknown COVID infections.PMID:38429542 | DOI:10.1007/s00106-024-01435-w (Source: HNO)
Source: HNO - March 1, 2024 Category: ENT & OMF Authors: Thomas Gehrke Agmal Scherzad Source Type: research