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[Complications and side effects of conservative treatment of rhinological diseases].
CONCLUSION: Particularly when treating children or pregnant or breastfeeding women, the indications of all nasal preparations should be checked carefully. The huge variety of rhinologicals enables an optimal individual selection on the basis of consideration of known side effects. PMID: 29767298 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - May 18, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Recognition and prevention of problems in lacrimal duct surgery].
Authors: Kühnel T Abstract Surgical management of lacrimal duct obstruction beyond the canaliculi proves to be a promising endeavor in most cases. To realize the full potential of endonasal dacryocystorhinostomy, some aspects of diagnosis and differential indication setting should be considered in order to avoid errors and problems during patient selection, execution of the technical procedure, and communication with ophthalmologists. These issues are described according to the clinical management of patients; current literature is cited. PMID: 29761204 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - May 17, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Complications of anterior skull base surgery].
Authors: Wagenmann M, Scheckenbach K, Kraus B, Stenin I Abstract Anterior skull base operations are complex surgical procedures that are performed to treat serious and complicated diseases. Despite significant advances in surgical techniques, complications are relatively frequent and can be serious. Endoscopic skull base surgery seems to be associated with less complications than open techniques. Different classifications aimed at categorizing these complications have been suggested, the use of which can be recommended when reporting complication rates. The most relevant and frequent complications of anterior skull...
Source: HNO - May 11, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Management of developmental speech-language disorders in children : Part  1: Diagnosis and underlying comorbid diseases].
[Management of developmental speech-language disorders in children : Part 1: Diagnosis and underlying comorbid diseases]. HNO. 2018 May 04;: Authors: Schönweiler R Abstract Compared to other countries, the prevalence of speech-language disorders among children and also the intervention frequency appear to be much higher in Germany. Since otorhinolaryngologists often initiate speech-language interventions, the first part of this review systematically outlines the guideline-conform diagnostic pathway from examination to therapeutic intervention. The process of first developing a suspected ...
Source: HNO - May 9, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Bothersome tinnitus : Cognitive behavioral perspectives.
Authors: Cima RFF Abstract Tinnitus is not traceable to a single disease or pathology, but merely a symptom, which is distressing to some but not all individuals able to perceive it. The experience of tinnitus does not equate to tinnitus distress. Tinnitus suffering might be understood as a function of tinnitus-related distress in that bothersome tinnitus is an illness rather than a disease. In bothersome (distressing) tinnitus, the perception of the characteristic sound is a very disturbing and bothersome experience because of maladaptive psychological responses. Several cognitive and beha...
Source: HNO - May 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Update HNO.
Authors: PMID: 29713759 [PubMed - in process] (Source: HNO)
Source: HNO - May 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Diagnosis and treatment of Osler's disease].
Authors: Haubner F, Kühnel T Abstract Osler's disease is an autosomal dominant hereditary syndrome which belongs to the group of orphan diseases. Affected patients suffer primarily from severe epistaxis. Diagnosis is based on the Curaçao criteria and molecular genetic tests. Organ manifestations can be found in the form of arteriovenous shunts in the lung, liver, and gastrointestinal tract; more rarely also in the central nervous system (CNS) and other parts of the body. Many patients with gastrointestinal and other organ manifestations are frequently clinically asymptomatic; therefore, organ screening ...
Source: HNO - April 27, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Conflicts of interest in guidelines].
Authors: Stuck BA PMID: 29654330 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - April 15, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Research Today-Future Tomorrow : 89th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery].
Authors: Wollenberg B PMID: 29619537 [PubMed - in process] (Source: HNO)
Source: HNO - April 7, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[The German Society of Otorhinolaryngology, Head and Neck Surgery award winners 2015 and 2017].
Authors: Praetorius M PMID: 29619538 [PubMed - in process] (Source: HNO)
Source: HNO - April 7, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Plastische Operationen.
Authors: PMID: 29619539 [PubMed - in process] (Source: HNO)
Source: HNO - April 7, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[The role of innate immunity in otitis media].
Authors: Wigand M, Hoffmann TK, Ryan AF, Wollenberg B, Leichtle A Abstract Otitis media (OM) belongs to the most common pediatric diseases and causes more medical contacts, surgical interventions, and drug prescriptions than any other infectious disease. Recent findings have identified a critical role of innate immunity in recovery from OM. The middle ear mucosa identifies invading pathogens by sensing pathogen-associated molecule patterns (PAMPs) via pattern recognition receptors such as the Toll-like receptors (TLRs). They generate immediate antimicrobial responses and cytokine release, leading to an inflamm...
Source: HNO - March 29, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Staging of oropharyngeal carcinomas : New TNM classification as a  challenge for head and neck cancer centers].
CONCLUSION: Clinical trials will have to show whether deescalation strategies regarding p16-positive carcinomas are supported by the changes made in the TNM staging system. A prospective multicenter study should examine the universal applicability, the appropriateness for all sublocations, as well as the prognostic significance of the current edition. PMID: 29536123 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 16, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Dependency of APHAB score in the ECu subscale on age, gender and subjective hearing loss : Hearing aid fitting in two subjective hearing loss groups].
CONCLUSION: The distribution with two maximums in the ECu subscale can be explained by individual differences in terms of age and hearing loss, in part also by gender. The lower absolute number of patients in group 1 could be explained by the still relatively late fitting of hearing aids in general. PMID: 29532108 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 15, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Regulatory dysfunctions in nasal polyposis].
Authors: Koennecke M, Pries R, Wollenberg B Abstract Chronic rhinosinusitis is a heterogeneous group of inflammatory diseases with significant annual costs for the health care system. To date, there is no distinct signaling pathway known that explains the entire process from the beginning to tissue transformation. Due to the diversity of chronic rhinosinusitis, no uniform treatment has yet been developed. With a focus on chronic rhinosinusitis with nasal polyps (CRSwNP), molecular biologic gene expression studies have been performed to identify specific characteristics of nasal polyps that might allow the...
Source: HNO - March 9, 2018 Category: ENT & OMF Tags: HNO Source Type: research

On the classification of hydropic ear disease (Meni ère's disease).
On the classification of hydropic ear disease (Menière's disease). HNO. 2018 Mar 02;: Authors: Gürkov R, Hornibrook J Abstract More than 150 years after its initial description by Prosper Menière, the disease named after him is still at the center of scientific debates. Two recent developments have specifically created a breeding ground for controversy: (1) Since its first description 10 years ago, magnetic resonance imaging diagnosis of endolymphatic hydrops in living patients has seen an increasing and worldwide application. (2) The Bárány Soc...
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Rare differential diagnosis of conductive hearing loss in childhood].
Authors: Pein MK, Rahne T, Noll A, Plontke SK PMID: 29500498 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Medical examination: preparation for ENT specialisation : Part  35].
[Medical examination: preparation for ENT specialisation : Part 35]. HNO. 2018 Mar 02;: Authors: Offergeld C, Alballaa A PMID: 29500499 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[B  cells in head and neck oncology].
[B cells in head and neck oncology]. HNO. 2018 Mar 02;: Authors: Schuler PJ, Brunner C, Hoffmann TK Abstract As immunotherapy is becoming increasingly important in the treatment of head and neck cancer, a fundamental understanding of the immunological relationships in the tumor microenvironment is required. The importance of tumor-infiltrating B cells (TIL-B) has been largely neglected so far. In the current literature, however, a significant influence of B cells on tumor growth is described, so that this cell population is now also perceived as a therapeutic target struct...
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Tinnitus-New challenge and therapeutic approaches.
Authors: Mazurek B PMID: 29500501 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Diagnostics and management of choanal atresia].
Authors: Baumann I, Sommerburg O, Amrhein P, Plinkert PK, Koitschev A Abstract Choanal atresia is a rare malformation that represents a special challenge. While bilateral choanal atresia usually needs to be surgically treated within a few days of birth, the intervention for one-sided choanal atresia can be postponed for years. Treatment planning requires adequate imaging (CT or MRI), which also serves to exclude other skull base malformities. Surgical treatment currently focuses on transnasal endoscopic techniques. Simultaneous resection of the parts of the vomer involved in the atresia seems to be i...
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Management of acute vertigo and dizziness : Patients in emergency departments in Germany].
CONCLUSIONS: In acute vertigo syndromes, the ENT physician has a special role and responsibility in the interdisciplinary workup, since ontological disorders are the most common cause. In any case, an ENT consultation is recommended. In German emergency departments, otorhinolaryngologists use modern diagnostic tools and algorithms such as the video head pulse test and HINTS to objectify peripheral vestibulopathy or identify central causes. Thus, this is a contribution to improving medical care. PMID: 29500503 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Hot Topic: Rheumatologie.
Authors: PMID: 29500510 [PubMed - in process] (Source: HNO)
Source: HNO - March 5, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Long-term changes in multimodal intensive tinnitus therapy : A  5‑year follow-up. German version].
CONCLUSION: The results of the present study support the effectiveness of the 7‑day multimodal intensive therapy for tinnitus. Posttreatment improvements were related to both tinnitus burden as well as stress and depressive symptoms and were maintained at the 5‑year follow-up. PMID: 29484461 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - March 1, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Noise-induced neurodegeneration in the central auditory pathway : An overview of experimental studies in a  mouse model].
CONCLUSION: Noise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information. PMID: 29464271 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 24, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Selected otorhinolaryngological symptoms in functional disorders of the upper cervical spine and temporomandibular joints].
Authors: Hölzl M, Behrmann R, Biesinger E, von Heymann W, Hülse R, Arens C Abstract This paper discusses otorhinolaryngological symptoms associated with functional disorders of the upper cervical spine. Hints aimed to avoid misdiagnoses of cross-organ otorhinolaryngological symptoms as phobic or psychogenic disorders are presented. Clinically relevant neuroanatomical convergence of the upper cervical spine (occiput to C3) is fundamental for the interpretation of functional otorhinolaryngological symptoms. Based thereon, evidence for the most common cervical differential diagnoses of dizziness, tinnitus, d...
Source: HNO - February 24, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[The innate immune system in oropharyngeal squamous cell carcinoma : Immune modulation by HPV].
Authors: Wagner S, Böckmann H, Gattenlöhner S, Klussmann JP, Wittekindt C Abstract Based on clinical and experimental data, oropharyngeal squamous cell carcinomas (OPSCC) associated with human papillomavirus (HPV) have been recognized as a distinct entity of head and neck cancers. However, outside of clinical trials, HPV status currently has no impact on treatment. The natural replication cycle of HPV takes place in epithelial cells, and is thus spatially separated from cytotoxic immune cells in the epidermis. Dendritic cells (Langerhans cells, LC), however, are frequent in this upper dermal layer. T...
Source: HNO - February 24, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[A  rare cause of swelling in the parotid region].
[A rare cause of swelling in the parotid region]. HNO. 2018 Feb 19;: Authors: Podzimek J, Jecker P, Daliri A PMID: 29460014 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 21, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Immuno-, radio-, and chemotherapeutic studies in head and neck cancer : Highlights of the ASCO Annual Meeting 2017].
Authors: Schuler PJ, von Witzleben A, Doescher J, Wollenberg B, Dietz A, Hoffmann TK Abstract In recent years, immunotherapy has been shown to be a promising approach for the treatment of various tumor entities. Due to further pharmacological developments and new studies, the checkpoint inhibitors have now arrived in the clinic. To date, patients with cancers in the head and neck region have benefited from these agents as part of a palliative therapy. Current clinical trials are testing other indications for the checkpoint inhibitors as monotherapy or in combination with other therapeutic approaches. The ...
Source: HNO - February 21, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Secondary acquired lacrimal duct obstruction and cervical lymphadenopathy].
Authors: Heichel J, Luci E, Struck HG, Siebolts U, Wickenhauser C, Plontke S, Viestenz A, Götze G PMID: 29460016 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 21, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Strategies for a  regenerative therapy of hearing loss. German version].
[Strategies for a regenerative therapy of hearing loss. German version]. HNO. 2018 Feb 15;: Authors: Diensthuber M, Stöver T Abstract Despite impressive technical progress in the field of conventional hearing aids and implantable hearing systems, the hopes for the treatment of inner ear diseases such as hearing loss and tinnitus have become increasingly directed toward regenerative therapeutic approaches. This review discusses the currently most promising strategies for hair cell regeneration in the inner ear to treat hearing loss, including stem cell-based, gene transfer-based, and pharmacol...
Source: HNO - February 17, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Erratum to: Long-term changes in multimodal intensive tinnitus therapy. A  5-year follow-up.
Erratum to: Long-term changes in multimodal intensive tinnitus therapy. A 5-year follow-up. HNO. 2018 Feb 09;: Authors: Brüggemann P, Otto J, Lorenz N, Schorsch S, Szczepek AJ, Böcking B, Mazurek B Abstract Erratum to:HNO 2018 66 (Suppl):S34-S38 https://doi.org/10.1007/s00106-017-0463-4 Figure 1 was published incorrectly in the online version of this paper. The correct Figure is reproduced below. PMID: 29426995 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 12, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Recurrent frontal swelling in a  child].
[Recurrent frontal swelling in a child]. HNO. 2018 Feb 09;: Authors: Gey A, Scheller C, Kunze C, Pazaitis N, Stiefel M, Plontke S PMID: 29426996 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 12, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Hot Topic: Infektiologie.
Authors: PMID: 29417189 [PubMed - in process] (Source: HNO)
Source: HNO - February 10, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Tinnitus  - New challenge and therapeutic approaches. German version].
[Tinnitus - New challenge and therapeutic approaches. German version]. HNO. 2018 Feb 07;: Authors: Mazurek B PMID: 29417190 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 10, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[New clinical applications for laser Doppler vibrometry in otology].
CONCLUSION: Many clinical questions in otology can be addressed by LDV. However, due to the high acquisition costs of an LDV system, the relatively large instrumental setup, and the large inter-ear variability of middle-ear function, the technique has not (yet) become established in clinical routine. PMID: 29417191 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 10, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Current aspects of tinnitus and depression].
Authors: Kratzsch V, Goebel G Abstract Health authorities underestimate the negative influence of emotional factors such as depression, anxiety disorders, or somatoform disorders in the development of tinnitus and their contribution to a poor prognosis. This can lead to underestimation of the impairment suffered by tinnitus patients and, consequently, a possibly incorrect treatment approach or belated initiation of therapy. Mental disorders play a large role in the S3AWMF "Tinnitus" guidelines. Thus, the somatic and psychiatric approaches for treatment of chronic tinnitus patients are combi...
Source: HNO - February 10, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Smartphone app-supported approaches to tinnitus therapy].
Authors: Hesse G Abstract In recent years, applications (apps) for medical purposes have been developed and introduced, including apps that perform diagnostics and documentation for hearing loss and tinnitus in combination with smartphones. Even therapeutic apps, particularly for chronic tinnitus, have been launched. This review discusses the existing scientific literature for these smartphone applications. For tinnitus, Internet-based cognitive behavioral therapy has been developed and evaluated. For tinnitus therapy, introduced apps combine acoustic stimulation and music, or serve acoustic stimulation of cortical...
Source: HNO - February 10, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Hyperacusis: major research questions.
CONCLUSION: This clinical/researcher-led project identified major research questions in hyperacusis. A further development to identify patient-prioritized research will follow. PMID: 29392341 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 4, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Medical examination: preparation for ENT specialisation : Part  34].
[Medical examination: preparation for ENT specialisation : Part 34]. HNO. 2018 Jan 30;: Authors: Nagel K, Zenk J PMID: 29383387 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - February 2, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Superior canal dehiscence syndrome : Diagnosis with vestibular evoked myogenic potentials and fremitus nystagmus. German version].
CONCLUSION: The subjective and clinical features in this case series of SCDS patients were heterogeneous. However, objective oVEMP testing had the highest diagnostic value. Furthermore, we describe a new diagnostic clinical sign: fremitus nystagmus. PMID: 29362817 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 25, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Rare cause of a supraclavicular swelling].
Authors: Bartmann D, Koppen T, Pieper CC, Bootz F, Send T PMID: 29356858 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 24, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Long-term changes in multimodal intensive tinnitus therapy : A 5 ‑year follow-up.
CONCLUSION: The results of the present study support the effectiveness of the 7‑day multimodal intensive therapy for tinnitus. Posttreatment improvements were related to both tinnitus burden as well as stress and depressive symptoms and were maintained at the 5‑year follow-up. PMID: 29350237 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 21, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Female patient with pulsatile tinnitus].
Authors: Biber F, Nolte CH, Albers AE PMID: 29350238 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 21, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Rhinoplasty-state of the art].
Authors: Berghaus A PMID: 29340737 [PubMed - in process] (Source: HNO)
Source: HNO - January 18, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Mittelohr.
Authors: PMID: 29340738 [PubMed - in process] (Source: HNO)
Source: HNO - January 18, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Dank an die Gutachter 2017.
Authors: PMID: 29340739 [PubMed - in process] (Source: HNO)
Source: HNO - January 18, 2018 Category: ENT & OMF Tags: HNO Source Type: research

Rhinoplasty: lessons from "errors" : From anatomy and experience to the concept of sequential primary rhinoplasty.
CONCLUSION: The goal to reduce the rate of revision rhinoplasty and to improve the natural results can be achieved, considering the concept of sequential primary rhinoplasty. Nasal soft tissues are protected as far as possible. The current rhinoplasty concepts are not antagonist but appear as an intraoperative succession of alternative techniques from anatomy and function preservation to reconstruction of the nasal framework. PMID: 29322251 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 14, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Diagnosis and treatment of Eustachian tube dysfunction].
Authors: Schröder S, Ebmeyer J Abstract The Eustachian tube protects against secretion, germs and sound pressure from the nasopharynx, it acts as a drain, and serves pressure equalization in both directions so that the ear drum and sound-conducting apparatus can vibrate optimally. The incidence of Eustachian tube dysfunction in adults is about 1%, in children almost 40%. Symptoms are often unspecific. For diagnosis, the Eustachian tube score (ETS-5) can be used in patients with a perforated ear drum, and the ETS-7 score in patients with intact ear drum. Adenoid hypertrophy is a frequent cause of obstructive tu...
Source: HNO - January 11, 2018 Category: ENT & OMF Tags: HNO Source Type: research

[Correction to: The physiologic and the pathologic swallowing process].
Authors: Cantemir S PMID: 29318323 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - January 11, 2018 Category: ENT & OMF Tags: HNO Source Type: research