Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice
This study aimed to explore the effectiveness of EE on emotional disorders after cerebral ischemia and its underling mechanism. In this study, sensorimotor cortical infarction was induced by photothrombosis with stable infarct location and volume, resulting in motor dysfunction, anxiety and depression-like behaviors in mice, with decreased ALFF and ReHo values and decreased c-fos expression in the infarction area and adjacent regions. Seven days' EE treatment significantly improved motor function of contralateral forelimb and exhibited anxiolytic and antidepressant effects in infarcted mice. Compared to the mice housing in...
Source: Experimental Neurology - April 30, 2024 Category: Neurology Authors: Dan Huang Yunhui Fan Jingjun Zhang Qianfeng Wang Ming Ding Ruiqing Hou Kewei Yu Xiao Xiao Yi Wu Junfa Wu Source Type: research
Atrial Septal Abnormalities and Cryptogenic Stroke: A Cross-Sectional Study
CONCLUSION: Based on our results, the prevalence of atrial septal abnormalities was relatively high. Considering these issues and the importance of preventing neurological accidents in patients, especially young people, it is recommended to always consider atrial septal disorders and, if diagnosed, to carry out the necessary treatment in this field.PMID:38685781 | DOI:10.2174/011871529X294809240415070950 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Marzieh Aliramezany Mansoor Moazenzadeh Amin Sayyadi Khadijeh Mohammadi Hamidreza Barzegar Maryam Aliramezany Source Type: research
GSE232244 Differential Expression Data from Mice 24hrs after stroke
Contributors : Reza Rahimian ; Revathy Guruswamy ; Hejer Boutej ; Pierre Cordeau Jr ; Yuan Cheng Weng ; Jasna KrizSeries Type : Expression profiling by arrayOrganism : Mus musculusMicroglial activation after stroke may lead to development of inflammation-induced brain damage. Here we uncover a ribosome-based mechanism/check point involved in control of the innate immune response and microglial activation orchestrated by RNA binding protein SRSF3. Using an in vivo model-system for analysis of the dynamic translational state of microglial ribosomes with mRNAs as input and newly synthesized peptides as an output, we fou...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Endovascular Thrombectomy for Large Ischemic Strokes with ASPECTS 0 –2: a Meta-analysis of Randomized Controlled Trials
ConclusionThis meta-analysis suggests a treatment effect of endovascular thrombectomy in specific patients with very low ASPECTS of 0–2, challenging the use of ASPECTS for treatment selection in acute ischemic stroke due to large vessel occlusion. An individual patient meta-analysis of RCTs would strengthen evidence in the treatment o f patients with ASPECTS of 0–2.Graphic abstract (Source: Klinische Neuroradiologie)
Source: Klinische Neuroradiologie - April 30, 2024 Category: Radiology Source Type: research
Safety and efficacy of intravenous thrombolysis before mechanical thrombectomy in patients with atrial fibrillation
ConclusionIVT plus EVT leads to better functional outcomes and lower mortality in AIS-LVO patients with AF. Withholding IVT plus EVT from patients with AF alone may not be justified. (Source: Systematic Reviews)
Source: Systematic Reviews - April 30, 2024 Category: International Medicine & Public Health Source Type: research
Unsupervised Machine Learning Revealed that Repeat Transcranial Magnetic Stimulation is More Suitable for Stroke Patients with Statin
ConclusionStroke patients undergoing rTMS treatment taking statins exhibited greater MEP, FFO, and changes in FMA. Statin intake was associated with a better prognosis in these patients. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 30, 2024 Category: Neurology Source Type: research
All Three Supersystems —Nervous, Vascular, and Immune—Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage
AbstractThe recently published DISCHARGE-1 trial supports the observations of earlier autopsy and neuroimaging studies that almost 70% of all focal brain damage after aneurysmal subarachnoid hemorrhage are anemic infarcts of the cortex, often also affecting the white matter immediately below. The infarcts are not limited by the usual vascular territories. About two-fifths of the ischemic damage occurs within ~ 48 h; the remaining three-fifths are delayed (within ~ 3 weeks). Using neuromonitoring technology in combination with longitudinal neuroimaging, the entire sequence of both early and delayed cortical infar...
Source: Translational Stroke Research - April 30, 2024 Category: Neurology Source Type: research
Differential ischemic stroke risk linked to novel subtypes of type 2 diabetes: insights from a Mendelian randomization analysis
ConclusionsOur study highlights distinct causal links between specific type 2 diabetes subtypes and ischemic stroke risks, emphasizing the importance of subtype-specific prevention and treatment strategies. (Source: Endocrine)
Source: Endocrine - April 30, 2024 Category: Endocrinology Source Type: research
The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation
This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.PMID:38682221 | DOI:10.31083/j.jin2304087 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Xin Gu Lingfei Li Biao Chen Yuyao Zhang Yongji Zhou Keqin Liu Wenqin Xia Xiaoqin Li Zheng Zhang Huanqing Shi Jinyu Huang Beibei Gao Lin Jiang Anwen Shao Congguo Yin Source Type: research
Added Clinical Value of Intraplaque Neovascularization Detection to Color Doppler Ultrasound for Assessing Ischemic Stroke Risk
CONCLUSION: Further assessment of intraplaque neovascularization after CDUS may help more accurately identify patients at risk of ischemic stroke. Combining multiparametric carotid ultrasound and clinical features may help improve the risk stratification of patients with ischemic stroke with ≥50% carotid stenosis.PMID:38681519 | PMC:PMC11055554 | DOI:10.2147/NDT.S456872 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Liuping Cui Ran Liu Fubo Zhou Yumei Liu Bing Tian Ying Chen Yingqi Xing Source Type: research
Ischemic stroke in a patient with pseudoxanthoma elasticum and carotid rete mirabile
Nervenarzt. 2024 Apr 29. doi: 10.1007/s00115-024-01667-9. Online ahead of print.NO ABSTRACTPMID:38683355 | DOI:10.1007/s00115-024-01667-9 (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 29, 2024 Category: Neurology Authors: Lea Auksutat Volker He ßelmann G ünter Seidel Source Type: research
Clinicoradiological application of the use of spectral cranial computed tomography in the management of acute ischemic stroke after mechanical thrombectomy
CONCLUSIONS: Spectral CT provides high diagnostic confidence to the radiologist in identifying the type of detected hyperdensity, thereby offering significant therapeutic confidence to the neurologist in early resuming anticoagulation therapy.PMID:38682762 | DOI:10.33588/rn.7809.2023340 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 29, 2024 Category: Neurology Authors: L Moreno-Navarro M Farrerons-Llopart N L ópez-Hernández S Moliner-Castellano M J Ballesteros-Aparicio J Gallego-Le ón L Concepci ón-Aramendía Source Type: research
NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway
CONCLUSIONS: NEAT1 inhibits the angiogenic activity of mCAECs by inducing M1 polarization of BV-2 cells through the AMPK signaling pathway. This study further clarified the impact and mechanism of NEAT1 on microglia and the angiogenic ability of cerebrovascular endothelial cells.PMID:38684954 | DOI:10.1186/s11658-024-00579-5 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Ting Chen Xin Huang Yi-Xuan Zhao Zhi-Wen Zhou Wen-Sheng Zhou Source Type: research
NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway
CONCLUSIONS: NEAT1 inhibits the angiogenic activity of mCAECs by inducing M1 polarization of BV-2 cells through the AMPK signaling pathway. This study further clarified the impact and mechanism of NEAT1 on microglia and the angiogenic ability of cerebrovascular endothelial cells.PMID:38684954 | DOI:10.1186/s11658-024-00579-5 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - April 29, 2024 Category: Biochemistry Authors: Ting Chen Xin Huang Yi-Xuan Zhao Zhi-Wen Zhou Wen-Sheng Zhou Source Type: research
The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation
This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.PMID:38682221 | DOI:10.31083/j.jin2304087 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Xin Gu Lingfei Li Biao Chen Yuyao Zhang Yongji Zhou Keqin Liu Wenqin Xia Xiaoqin Li Zheng Zhang Huanqing Shi Jinyu Huang Beibei Gao Lin Jiang Anwen Shao Congguo Yin Source Type: research
