Argon neuroprotection in ischemic stroke and its underlying mechanism
Brain Res Bull. 2024 Apr 24:110964. doi: 10.1016/j.brainresbull.2024.110964. Online ahead of print.ABSTRACTIschemic stroke (IS), primarily caused by cerebrovascular obstruction, results in severe neurological deficits and has emerged as a leading cause of death and disability worldwide. Recently, there has been increasing exploration of the neuroprotective properties of the inert gas argon. Argon has exhibited impressive neuroprotection in many in vivo and ex vivo experiments without signs of adverse effects, coupled with the advantages of being inexpensive and easily available. However, the efficient administration strate...
Source: Brain Research - April 26, 2024 Category: Neurology Authors: Li Bao Yongxin Liu Qi Jia Sihao Chu Han Jiang Shuang He Source Type: research
Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment
CONCLUSION: EA ameliorates memory impairment in a rat model of ischemic stroke by reducing inflammation and ROS through the inhibition of P2X7R expression. In turn, this mechanism regulates Nrf2 and NLRP3 expression, suggesting EA is beneficial for ischemic stroke treatment using P2X7R as target.PMID:38670470 | DOI:10.1016/j.brainresbull.2024.110967 (Source: Brain Research)
Source: Brain Research - April 26, 2024 Category: Neurology Authors: Bingbing Lin Mengxue Wang Xiaocheng Chen Linsong Chai Jinglei Ni Jia Huang Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke
Ischemic stroke remains the predominant contributor to mortality and disability globally. Microglia undergo rapid activation and initiate inflammatory cascade reactions by phenotypic polarization, participating in the regulation of inflammatory injury and tissue repair post-ischemic stroke. Regulating microglia-mediated neuroinflammation is a promising therapeutic strategy for ischemic stroke. Previously, we designed and synthesized a novel p55PIK inhibitor, TAT-N15 polypeptide, which presents inhibitive activity on NF- κB signaling-mediated inflammation in acute conjunctivitis and allergic rhinitis. (Source: Journal of S...
Source: Journal of Stroke and Cerebrovascular Diseases - April 26, 2024 Category: Neurology Authors: Yujing Liu, Changlong Leng, Youwei Li, Meiling Zhou, Xiansheng Ye, Chaoxing Li, Xianmin Xia, Binlian Sun, Xiji Shu, Wei Liu Source Type: research
