Nomogram to Predict 90-Day All-Cause Mortality in Acute Ischemic Stroke Patients after Endovascular Thrombectomy
CONCLUSION: Our nomogram has incorporated relevant clinical and imaging features, including neurological deterioration, age, baseline NIHSS score, occlusive vessel location, malignant brain edema, and NLR ratio, to provide an accurate and reliable prediction of 90-day all-cause mortality in AIS patients undergoing EVT.PMID:38676479 | DOI:10.2174/0115672026311086240415050048 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 27, 2024 Category: Neurology Authors: Shiya Zhang Shuai Yu Xiaocui Wang Zhiliang Guo Jie Hou Huaishun Wang Zhichao Huang Guodong Xiao Shoujiang You Source Type: research
Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
This study provides supporting evidence that environmental lighting exacerbates ischemic injury and post-stroke mortality by a biological mechanism, that exposure to dLAN causes a fundamental shift of activated microglial phenotypes from beneficial to detrimental at an early time point after stroke, resulting in irreversible neuronal death.PMID:38677449 | DOI:10.1016/j.expneurol.2024.114796 (Source: Experimental Neurology)
Source: Experimental Neurology - April 27, 2024 Category: Neurology Authors: Jennifer A Liu William H Walker O Hecmarie Mel éndez-Fernández Jacob R Bumgarner Ning Zhang James C Walton Gordon P Meares A Courtney DeVries Randy J Nelson Source Type: research
Dystextia and dystypia due to phonological errors after ischemic stroke: a case report in a Japanese patient
Neurocase. 2024 Apr 26:1-8. doi: 10.1080/13554794.2024.2345403. Online ahead of print.ABSTRACTA 69-year-old Japanese male presented with acute dystextia and dystypia, defined as texting and typing impairments, respectively. His text input speed decreased due to a phonologically incorrect kana flick input on his smartphone. Additionally, dystypia occurred due to phonemic paragraphia of Romaji. Brain MRI revealed a new left lenticulostriate infarction sparing the cerebral cortex. SPECT showed reduced cerebral blood flow in the left inferior precentral frontal gyrus as well as in the infarction area. It was concluded that his...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Hiroshi Adachi Jun Numata Katsuya Nishida Hiroshi Yamasaki Naonobu Futamura Source Type: research
Role of intracranial bone marrow mesenchymal stem cells in stroke recovery: A focus on post-stroke inflammation and mitochondrial transfer
Brain Res. 2024 Apr 25:148964. doi: 10.1016/j.brainres.2024.148964. Online ahead of print.ABSTRACTStem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mechanism ...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Jiang Ming Yidong Liao Wenxue Song Zili Wang Junshuan Cui Longcai He Guangtang Chen Kaya Xu Source Type: research
Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research
Long-Term Alterations in Motor Skills, Neurogenesis and Astrocyte Numbers following Transient Cerebral Ischemia in Mice
Conclusions: Our current report demonstrates the long-term effects of transient cerebral ischemia on mice functional parameters and neurogenesis progression. Our data demonstrate that transient cerebral ischemia promotes a long-lasting regenerative response in the ipsilateral brain hemisphere, specifically in the neurogenic SVZ and DG regions.PMID:38674304 | PMC:PMC11052140 | DOI:10.3390/medicina60040658 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Vladimirs Pilipenko Jolanta Upite Beatrise Luize Revina Baiba Jansone Source Type: research
Design, Synthesis, and Biological Evaluation of Novel Cinnamide Derivatives as Neuroprotective Agents for the Treatment of Cerebral Ischemia
CONCLUSION: Compounds 9t, 9u, 9y, and 9z, as potent neuroprotective agents with anti- neurotoxicity activity in vitro and anticerebral infarction efficacy in vivo, might serve as a useful molecular tool for further physiology and pathophysiology function studies, leading to potential clinical therapeutic agents for ischemic injury.PMID:38676480 | DOI:10.2174/0109298673302111240418060441 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Yan Zhong Yi Xu Xin-Zhu Tan Yu-Ying Wang Shuang-Yan Ma Meng-Jie Gao Bin Wu Source Type: research
Optimizing catheter centering enhances mechanical thrombectomy success: Performance difference in cases using novel macrowires versus traditional microwires
CONCLUSION: Large 0.018″ or 0.024″ OD guidewires better fill the lumen of the catheter and help to center the thrombectomy system in the vessel and navigate to the clot face. This leads to a reduction in procedure time and number of passes, and an increase in first pass success, especially when treating occlusions in the ICA.PMID:38676326 | DOI:10.1177/15910199241249212 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - April 27, 2024 Category: Radiology Authors: Ameer E Hassan Wondwossen G Tekle Hamzah Saei Source Type: research
Molecular Pathways of Vulnerable Carotid Plaques at Risk of Ischemic Stroke: A Narrative Review
Int J Mol Sci. 2024 Apr 15;25(8):4351. doi: 10.3390/ijms25084351.ABSTRACTThe concept of vulnerable carotid plaques is pivotal in understanding the pathophysiology of ischemic stroke secondary to large-artery atherosclerosis. In macroscopic evaluation, vulnerable plaques are characterized by one or more of the following features: microcalcification; neovascularization; lipid-rich necrotic cores (LRNCs); intraplaque hemorrhage (IPH); thin fibrous caps; plaque surface ulceration; huge dimensions, suggesting stenosis; and plaque rupture. Recognizing these macroscopic characteristics is crucial for estimating the risk of cerebr...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Giuseppe Miceli Maria Grazia Basso Chiara Pintus Andrea Roberta Pennacchio Elena Cocciola Mariagiovanna Cuffaro Martina Profita Giuliana Rizzo Antonino Tuttolomondo Source Type: research
Nomogram to Predict 90-Day All-Cause Mortality in Acute Ischemic Stroke Patients after Endovascular Thrombectomy
CONCLUSION: Our nomogram has incorporated relevant clinical and imaging features, including neurological deterioration, age, baseline NIHSS score, occlusive vessel location, malignant brain edema, and NLR ratio, to provide an accurate and reliable prediction of 90-day all-cause mortality in AIS patients undergoing EVT.PMID:38676479 | DOI:10.2174/0115672026311086240415050048 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 27, 2024 Category: Neurology Authors: Shiya Zhang Shuai Yu Xiaocui Wang Zhiliang Guo Jie Hou Huaishun Wang Zhichao Huang Guodong Xiao Shoujiang You Source Type: research
Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
This study provides supporting evidence that environmental lighting exacerbates ischemic injury and post-stroke mortality by a biological mechanism, that exposure to dLAN causes a fundamental shift of activated microglial phenotypes from beneficial to detrimental at an early time point after stroke, resulting in irreversible neuronal death.PMID:38677449 | DOI:10.1016/j.expneurol.2024.114796 (Source: Experimental Neurology)
Source: Experimental Neurology - April 27, 2024 Category: Neurology Authors: Jennifer A Liu William H Walker O Hecmarie Mel éndez-Fernández Jacob R Bumgarner Ning Zhang James C Walton Gordon P Meares A Courtney DeVries Randy J Nelson Source Type: research
Dystextia and dystypia due to phonological errors after ischemic stroke: a case report in a Japanese patient
Neurocase. 2024 Apr 26:1-8. doi: 10.1080/13554794.2024.2345403. Online ahead of print.ABSTRACTA 69-year-old Japanese male presented with acute dystextia and dystypia, defined as texting and typing impairments, respectively. His text input speed decreased due to a phonologically incorrect kana flick input on his smartphone. Additionally, dystypia occurred due to phonemic paragraphia of Romaji. Brain MRI revealed a new left lenticulostriate infarction sparing the cerebral cortex. SPECT showed reduced cerebral blood flow in the left inferior precentral frontal gyrus as well as in the infarction area. It was concluded that his...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Hiroshi Adachi Jun Numata Katsuya Nishida Hiroshi Yamasaki Naonobu Futamura Source Type: research
Role of intracranial bone marrow mesenchymal stem cells in stroke recovery: A focus on post-stroke inflammation and mitochondrial transfer
Brain Res. 2024 Apr 25;1837:148964. doi: 10.1016/j.brainres.2024.148964. Online ahead of print.ABSTRACTStem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mecha...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Jiang Ming Yidong Liao Wenxue Song Zili Wang Junshuan Cui Longcai He Guangtang Chen Kaya Xu Source Type: research
Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research
Long-Term Alterations in Motor Skills, Neurogenesis and Astrocyte Numbers following Transient Cerebral Ischemia in Mice
Conclusions: Our current report demonstrates the long-term effects of transient cerebral ischemia on mice functional parameters and neurogenesis progression. Our data demonstrate that transient cerebral ischemia promotes a long-lasting regenerative response in the ipsilateral brain hemisphere, specifically in the neurogenic SVZ and DG regions.PMID:38674304 | PMC:PMC11052140 | DOI:10.3390/medicina60040658 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Vladimirs Pilipenko Jolanta Upite Beatrise Luize Revina Baiba Jansone Source Type: research
