Healing the Heart with Sirtuins and Mammalian Forkhead Transcription Factors.
PMID: 31814554 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - December 9, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Isoflurane-induced miR-140-5p aggravates neurotoxicity in diabetic rats by targeting SNX12.
CONCLUSIONS: Knockdown of miR-140-5p relieved isoflurane-aggravated neurotoxicity in diabetic rats through targeting SNX12, suggesting a novel target for neuroprotection in diabetes under isoflurane treatment. PMID: 31746297 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - November 19, 2019 Category: Neurology Authors: Fan D, Yang S, Han Y, Zhang R, Yang L Tags: Curr Neurovasc Res Source Type: research

MiR-22-3p regulates amyloid β deposit in mice model of Alzheimer's disease by targeting mitogen-activated protein kinase 14.
MiR-22-3p regulates amyloid β deposit in mice model of Alzheimer's disease by targeting mitogen-activated protein kinase 14. Curr Neurovasc Res. 2019 Nov 11;: Authors: Ji Q, Wang X, Cai J, Du X, Sun H, Zhang N Abstract Propose: To investigate whether miR-22-3p is able to regulate AD development and its molecular mechanism. Methods: Morris water maze test was performed to test the spatial memory. Quantitative polymerase chain reaction (qPCR) was used to assess the expression level of miR-22-3p. The enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of Aβ40 and Aβ42. ...
Source: Current Neurovascular Research - November 11, 2019 Category: Neurology Authors: Ji Q, Wang X, Cai J, Du X, Sun H, Zhang N Tags: Curr Neurovasc Res Source Type: research

microRNA-212-3p attenuates neuropathic pain via targeting sodium voltage-gated channel alpha subunit 3 (NaV 1.3).
CONCLUSION: Expression of miR-212a-3p attenuates neuropathic pain via targeting NaV1.3. PMID: 31713483 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - November 10, 2019 Category: Neurology Authors: Li Y, Zhang X, Fu Z, Zhou Q Tags: Curr Neurovasc Res Source Type: research

Association of Common Variants in the IL-33/ST2 Axis with Ischemic Stroke.
CONCLUSION: Our findings suggested an association between common variants in the IL-33/ST2 axis and a decreased risk of ischemic stroke in the Han Chinese population. PMID: 31660817 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - October 29, 2019 Category: Neurology Authors: Li S, Wang Z, Liu X, Li Y, Shi C, Wu J, Sun S, Li Y, Li S, Xu Y, Song B Tags: Curr Neurovasc Res Source Type: research

Curcumin prevents brain damage and cognitive dysfunction during ischemic-reperfusion through the regulation of miR-7-5p.
CONCLUSION: Curcumin exerts cerebral protection by attenuating cell necrosis and apoptosis, inflammatory response and oxidative stress following CIR, which may be related to its regulation of the miR-7/RELA p65 axis. PMID: 31660818 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - October 29, 2019 Category: Neurology Authors: Xu H, Nie B, Liu L, Zhang C, Zhang Z, Xu M, Mei Y Tags: Curr Neurovasc Res Source Type: research

Role of granulocyte colony-stimulating factor in protection of cerebral vascular endothelium, white matter, and cognition.
CONCLUSION: Therefore,our findings indicated that G-CSF may facilitate non-spatial cognitive function improvement in CSVD by repairing endothelial cells and alleviating WM damage. PMID: 31660819 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - October 29, 2019 Category: Neurology Authors: Tuo M, Xiao Y, Xu Y, Wang L, Wei X, Zhang L Tags: Curr Neurovasc Res Source Type: research

Dissecting the Biological Effects of Isoflurane through the Mechanistic Target of Rapamycin (mTOR) and microRNAs (miRNAs).
PMID: 31647393 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - October 24, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Radial glia-Endothelial cells bidirectional interactions control vascular maturation and astrocyte differentiation: impact for blood brain barrier formation.
CONCLUSION: These results suggest that the bidirectional interaction between RG and ECs is essential to induce vascular maturation and astrocyte generation, which may be an essential cell-cell communication mechanism to promote BBB establishment. PMID: 31633476 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - October 14, 2019 Category: Neurology Authors: Silva Siqueira MD, Gisbert DC, Gomes FCA, Stipursky J Tags: Curr Neurovasc Res Source Type: research

Erythropoietin gene polymorphism rs551238 is associated with a reduced susceptibility to brain injury in preterm infants.
Abstract BACKGROUND: Single nucleotide polymorphisms (SNPs) in the erythropoietin (EPO) promoter region have been shown to influence EPO protein expression, and high blood levels of EPO are associated with an increased risk of brain injury in very preterm infants. Here we investigated the genotype distributions and association of three EPO gene polymorphisms (rs1617640, rs551238, and rs507392) with the risk of brain injury in preterm infants. METHODS: 304 preterm infants with a gestational age of 28 to 34 weeks were enrolled in this study. Brain injury was evaluated by brain ultrasound and MRI examination. EP...
Source: Current Neurovascular Research - October 14, 2019 Category: Neurology Authors: Xu J, Li H, Huang J, Wang Z, Li Y, Yang C, Wu B, Liu L, Kong Q, Huang J, Liu W, Ye X, Chen G Tags: Curr Neurovasc Res Source Type: research

Neonatal Immune Activation May Provoke Long-Term Depressive Attributes.
CONCLUSION: These results suggest that neonatal immune activation may be associated with depressive-like parameters in adulthood. It is believed that endotoxemia may trigger physiological and behavioral alterations, increasing vulnerability to the development of depression in adulthood. PMID: 31589124 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - October 7, 2019 Category: Neurology Authors: Schelder-Marzzani SH, Dias P, Freiberger V, Ventura L, Silva BB, Dutra ML, Bobinski F, Schlindwein AD, Cassol-Jr OJ, Comim CM Tags: Curr Neurovasc Res Source Type: research

Blood-brain barrier disruption may contribute to white matter lesions in the setting of internal jugular venous stenosis.
This study aims to evaluate blood-brain barrier integrity of the patients with IJVS. METHODS: A total of 45 eligible patients with internal jugular venous stenosis confirmed by contrast-MRV and 45 healthy controls were enrolled into this study. The levels of serum MMP-9 and the markers of tight junctions, including occludin and ZO-1 obtained from IJVS patients and control group were tested by enzyme-linked immune-sorbent assay and compared. RESULTS: Both the levels of serum MMP-9 (0.2ng/ml) and occludin (0.05ng/ml) in IJVS group were higher than in the control group (0.01ng/ml vs 0 ng/ml, all p
Source: Current Neurovascular Research - October 1, 2019 Category: Neurology Authors: Wu Y, Meng R, Rajah GB, Ding Y, Xu Y, Ji X Tags: Curr Neurovasc Res Source Type: research

Knowing When to Trust Your Gut: The Intimate Relationship Between Neurodegenerative Diseases and the Brain-Gut Axis.
Abstract PMID: 31560281 [PubMed - in process] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 29, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Depressed serum 25-Hydroxyvitamin D levels increases hospital stay and alters glucose homeostasis in first ever ischemic stroke.
CONCLUSIONS: 25(OH)D levels are associated with glucose homeostasis ,25(OH) D contributes to increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital stay in first-ever ischemic stroke, Vitamin D deficiency did not predict functional outcome at 3 months. PMID: 31549956 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 24, 2019 Category: Neurology Authors: Wang Y, Wang Y, Zhang B, Lin Y, Tan S, Lu Z Tags: Curr Neurovasc Res Source Type: research

Prediction Model of Early Return to Hospital after Discharge Following Acute Ischemic Stroke.
CONCLUSIONS: Although CART analysis did not improve the prediction of an early return to hospital after stroke compared with logistic regression models, decision rules generated by CART can easily be interpreted and applied in clinical practice. PMID: 31544716 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 11, 2019 Category: Neurology Authors: Lee JD, Lee TH, Huang YC, Lee M, Kuo YW, Huang YC, Hu YH Tags: Curr Neurovasc Res Source Type: research

Gender differences in characteristics and outcome in primary intraventricular hemorrhage.
CONCLUSIONS: Women with PIVH exhibit some distinctive baseline features compared with men. The gender difference of the PIVH does not appear to affect the neurological outcome. The predictors of poor outcomes are Graeb score and AMC in women and GCS score and acute hydrocephalus in men. PMID: 31490753 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 6, 2019 Category: Neurology Authors: Guo R, Yin L, Chen R, Zhou L, You C, Ma L, Li H Tags: Curr Neurovasc Res Source Type: research

Prognostic Value of Cystatin C in Acute Ischemic Stroke Patients with Intravenous Thrombolysis.
Abstract BACKGROUND: Less is known about the prognostic value of serum cystatin C in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT). The aim of the present study was to examine the association between serum cystatin C levels and prognosis of AIS patients after IVT. METHODS: Serum cystatin C was measured within 24 hours after recombinant tissue plasminogen activator (rt-PA) treatment in 280 consecutively recruited patients with AIS. Main outcomes included combination of death and major disability, death, major disability (modified Rankin Scale score 3-5) and vascular events at...
Source: Current Neurovascular Research - September 6, 2019 Category: Neurology Authors: Shi J, Zhang C, Cao Y, Qu X, Liu H, You S Tags: Curr Neurovasc Res Source Type: research

MiR-125b-5p inhibitor might protect against sevoflurane-induced cognitive impairments by targeting to LIMK1.
CONCLUSION: Altogether, these findings suggested that miR-125b-5p inhibitor could protect against the sevoflurane-induced cognitive impairments by targeting to LIMK1. PMID: 31490755 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 6, 2019 Category: Neurology Authors: Xiong J, Wang H, Mu F, Liu Z, Bao Y, Sun Y Tags: Curr Neurovasc Res Source Type: research

miR-125a-5p alleviates dysfunction and inflammation of pentylenetetrazol-induced epilepsy through targeting calmodulin-dependent protein kinase IV (CAMK4).
CONCLUSION: miR-125a-5p may represent a novel therapeutic treatment for PTZ-induced epilepsy by preventing the activation of CAMK4. PMID: 31490757 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 6, 2019 Category: Neurology Authors: Liu Q, Wang L, Yan G, Zhang W, Huan Z, Li J Tags: Curr Neurovasc Res Source Type: research

MiR-34a inhibits spinal cord injury and blocks spinal cord neuron apoptosis by activating phatidylinositol 3-kinase (PI3K)/AKT pathway through targeting CD47.
CONCLUSION: MiR-34a can downregulate CD47 expression to activate PI3K/AKT signal pathway, and thus inhibit SCI induced spinal neuron apoptosis. PMID: 31490756 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 5, 2019 Category: Neurology Authors: Qi L, Jiang-Hua M, Ge-Liang H, Qing C, Ya-Ming L Tags: Curr Neurovasc Res Source Type: research

Vitamin D as a Potential Agent for Ischemic Axonal Regeneration after Epineurial Devascularization of the Sciatic Nerve.
In this study it was aimed to investigate the effect of vitamin D3 after epineurial devascularization of the sciatic nerve. Forty adult female Wistar rats were randomly divided into four groups: Group 1 (Control), Group 2 (Sham-operated), Group 3 (Epineurial devascularization + vitamin D3 treatment), Group 4 (Epineurial devascularization + vehicle treatment). Recovery of the sciatic nerve was analyzed by functional (sciatic functional index, pinch test and biochemical analyses) and morphological (electron microscopic analysis and wet muscle weight analysis) methods. Comparison of the data revealed that vitamin D3 administr...
Source: Current Neurovascular Research - September 5, 2019 Category: Neurology Authors: Erdem H, Sarikcioglu L, Boyan N, Oguz O Tags: Curr Neurovasc Res Source Type: research

Releasing the Genie in the Bottle: Molecular Signaling with Hydrogen Sulfide.
Abstract PMID: 31433748 [PubMed - in process] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 23, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Preserving Brain Function During Development and Aging with Erythropoietin.
PMID: 31433758 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 21, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Potential role for the existence of pericytes in the neurovascular unit of the sexually dimorphic nucleus of the rat preoptic area to control blood brain barrier function.
Abstract BACKGROUND: The present study aimed at determining pericytes, a missing component in the previously proposed living neurovascular unit (NVU) of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in rats. Materials and Mehods: Calbindin D28K-immunoreactivities (CB28-irs) were used to delineate the SDN-POA in which CD13-immunoreactivities (CD13-irs) or alpha-smooth muscle actin-immunoreactivities (αSMA-irs), two pericyte biomarkers serving the indexes of pericytes, were tagged using two adjacent brain sections (90-micron intervals). In addition, the nestin-immunoreactive (nestin-ir) cells i...
Source: Current Neurovascular Research - June 27, 2019 Category: Neurology Authors: He Z, Patterson TA Tags: Curr Neurovasc Res Source Type: research

Artificial Hibernation by Phenothiazines: A Potential Neuroprotective Therapy Against Cerebral Inflammation in Stroke.
CONCLUSION: This study showed an inhibitory effect of C+P on brain inflammation, which may be partially dependent on drug-induced hibernation, as well as other mechanisms of action by these drugs. These findings further suggest the great potential of C+P in the clinical treatment of ischemic stroke. PMID: 31232236 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - June 24, 2019 Category: Neurology Authors: Guan L, Guo S, Yip J, Elkin KB, Li F, Peng C, Geng X, Ding Y Tags: Curr Neurovasc Res Source Type: research

Patterns of acute intracranial hemorrhage in adult patients with bilateral and unilateral moyamoya disease.
Abstract BACKGROUND: Moyamoya disease (MMD) is a rare cerebrovascular disease. The difference of hemorrhagic patterns in adult patients with bilateral and unilateral MMD is still unclear. OBJECTIVE: For a better understanding of their characteristics, we compared the patterns of acute intracranial hemorrhage in adult patients with bilateral and unilateral MMD. METHOD: Adult MMD patients with acute intracranial hemorrhage were retrospectively included. Clinical and radiological characteristics of adult patients with bilateral and unilateral MMD were collected and analyzed. Chi-square test, t-test, or rank...
Source: Current Neurovascular Research - June 20, 2019 Category: Neurology Authors: Yu Z, Zheng J, Guo R, Li H, You C, Ma L Tags: Curr Neurovasc Res Source Type: research

Decrease in secondary neck vessels in multiple sclerosis: A 5-year longitudinal magnetic resonance angiography study.
Abstract BACKGROUND: Studies have previously shown greater arterial and venous extracranial vascular changes in persons with multiple sclerosis (PwMS) when compared to healthy controls (HCs). OBJECTIVES: To determine the change in number and size of secondary neck vessels in PwMS and HCs over a 5-year follow-up period. METHODS: Both at baseline and follow-up, 83 PwMS and 25 HCs underwent magnetic resonance angiography (MRA) imaging and analysis. The number and cross-sectional area (CSA) of all secondary neck vessels (excluding the common/internal carotid, vertebral artery, and internal jugular vein) meas...
Source: Current Neurovascular Research - June 12, 2019 Category: Neurology Authors: Jakimovski D, Topolski M, Kimura K, Pandya V, Weinstock-Guttman B, Zivadinov R Tags: Curr Neurovasc Res Source Type: research

Knowing When to Trust Your Gut: The Intimate Relationship Between Neurodegenerative Diseases and the Brain-Gut Axis.
PMID: 31161977 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 27, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Releasing the Genie in the Bottle: Molecular Signaling with Hydrogen Sulfide
PMID: 31035743 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 30, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Association between blood urea nitrogen-to-creatinine ratio and three-month outcome in patients with acute ischemic stroke.
CONCLUSIONS: Elevated BUN/Cr is associated with poor three-month outcome in AIS patients with high HDL levels. PMID: 30977443 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Deng L, Wang C, Qiu S, Bian H, Wang L, Li Y, Wu B, Liu M Tags: Curr Neurovasc Res Source Type: research

What is the current role for vitamin D and the risk of stroke ?
Abstract Increasing evidence support the relationship between vitamin D and stroke. Vitamin D have now been proposed as a prognostic biomarker for also functional outcome in stroke patients. A revision of the data suggests that low vitamin D is associated more with ischemic than with haemorrhagic stroke, even if the role of optimal vitamin D levels for vascular wall is still unclear. Vitamin D deficiency induces with different mechanisms an alteration of vascular wall. However, to date, the research supporting the effectiveness of vitamin D supplementation in stroke and in post-stroke recovery is still inadequate ...
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Siniscalchi A, Lochner P, Anticoli S, Chirchiglia D, De Sarro G, Gallelli L Tags: Curr Neurovasc Res Source Type: research

Prognostic significance of serum magnesium in acute intracerebral hemorrhage patients.
Abstract BACKGROUND: Experimental animal model studies have shown neuroprotective properties of magnesium. We assessed the relationship between admission magnesium and admission stroke severity and 3-month clinical outcomes in patients with acute intracerebral hemorrhage (ICH). METHODS: The present study included 323 patients with acute ICH who were prospectively identified. Demographic characteristics, lifestyle risk factors, NIHSS score, hematoma volumes, and other clinical features were recorded at baseline for all participants. Patients was divided into three groups based on the admission magnesium levels (T1:
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Han X, You S, Huang Z, Han Q, Zhong C, Xu J, Shi R, Chen D, Xiao G, Zhang Y, Cao Y, Liu CF Tags: Curr Neurovasc Res Source Type: research

Lower serum indirect bilirubin levels are inversely related to carotid intima-media thickness progression.
CONCLUSION: The study demonstrated the inverse relationship between serum IBIL and CIMT progression. Lower serum IBIL level is an independent predictor of subclinical atherosclerosis. PMID: 30977446 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Tao X, Wu J, Wang A, Xu C, Wang Z, Zhao X Tags: Curr Neurovasc Res Source Type: research

PON1 hypermethylation and PON3 hypomethylation are associated with risk of cerebral infarction.
Conclusion: The study demonstrated the inverse relationship between serum IBIL and CIMT progression. Lower serum IBIL level is an independent predictor of subclinical atherosclerosis. PMID: 30977447 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Xiao J, Li X, Yuan Q, Zhang S, Qu K, Wu B, Wang Y, Duan S Tags: Curr Neurovasc Res Source Type: research

Gastrointestinal Hemorrhage Is Associated with Mortality after Acute Ischemic Stroke.
Abstract OBJECTIVE: Gastrointestinal (GI) hemorrhage is serious during the acute phase and reported to be related with an increased risk of death during the acute phase of acute ischemic stroke in particular. Our study was designed to investigate the relationship between GI hemorrhage and the mortality of acute ischemic stroke, assessing the influence of cerebrovascular risk factors, brain herniation and oral anticoagulation on the onset of GI hemorrhage. The identified risk factors for the occurrence of GI hemorrhage help to elucidate their respective roles in the mortality of acute ischemic stroke. METHODS:...
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Zhou Y, Xu W, Wang W, Yao S, Xiao B, Wang Y, Chen B Tags: Curr Neurovasc Res Source Type: research

A Direct Correlation Between Red Blood Cell Indices and Cognitive Impairment After Aneurysmal Subarachnoid Hemorrhage (aSAH).
CONCLUSIONS: In this aSAH population, our data shows the positive association between MCH and MCV and cognitive impairment at 1 year. PMID: 30977449 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 12, 2019 Category: Neurology Authors: Gong L, Gu Y, Dong Q, Zhang X, Wang H, Zhao Y, Liu X Tags: Curr Neurovasc Res Source Type: research

NSE, S100B and MMP9 Expression Following Reperfusion after Carotid Artery Stenting.
Abstract OBJECTIVE: Many studies have confirmed that the NSE, S100B and MMP9 were specific markers of cerebral injury. This paper was to evaluate the effect of NSE, S100B and MMP9 on reperfusion after carotid artery stenting (CAS). METHOD: We recruited 44 patients who were diagnosed unilateral carotid artery stenosis by digital subtraction angiography (DSA) as the operation group; Blood samples were collected at three time points, T1: preoperative, T2: first postoperative morning, T3: third postoperative morning. 12 patients who were excluded carotid artery stenosis by DSA were enrolled in control group; Bloo...
Source: Current Neurovascular Research - March 21, 2019 Category: Neurology Authors: Yuan X, Wang J, Wang D, Yang S, Yu N, Guo F Tags: Curr Neurovasc Res Source Type: research

Potential contribution of microRNA-125b targeting p38MAPK to relieving intermittent hypoxia-induced dementia of mice models.
Abstract INTRODUCTION: The purpose of this investigation was to elucidate whether miR-125b targeting p38MAPK could relieve cognitive impairment of obstructive sleep apnea hypopnea syndrome (OSAHS) mice models. MATERIAL AND METHODS: The mice models were categorized into untreated control (UC), 10% continuous hypoxic (CH), 10% chronic intermittent hypoxia (CIH) and 5% chronic intermittent hypoxia (CIH) groups. Morris Water Maze, spatial navigation test and spatial probe test were conducted to appraise the learning, memorizing and cognitive abilities of mice models. Moreover, miR-125b and p38MAPK expressions wer...
Source: Current Neurovascular Research - February 11, 2019 Category: Neurology Authors: Ren H, Qiu W, Peng C, Ding Y, Zhu B, Li Q, Chen X Tags: Curr Neurovasc Res Source Type: research

MicroRNAs for the Treatment of Dementia and Alzheimer's Disease.
Abstract PMID: 30732557 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 7, 2019 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

The U-shaped relationship between serum methylene tetrahydrofolate reductase and large-artery atherosclerotic stroke.
Abstract INTRODUCTION: Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms has been suggested to be associated with ischemic stroke. However, the association between serum MTHFR level and ischemic stroke has not yet been studied. We aimed to examine the association between them in patients with large-artery atherosclerotic stroke and community-based healthy controls. METHODS: Three hundred ninety-five patients with large-artery atherosclerotic stroke from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) and 395 age- and sex-matched healthy controls from communities in China were s...
Source: Current Neurovascular Research - February 7, 2019 Category: Neurology Authors: He Y, Zhu Z, Guo D, Zhang H, Zheng X, Zeng N, Zhang Q, Peng H, Zhong C, Wang A, Xu T, Jin J, Zhang Y, He J Tags: Curr Neurovasc Res Source Type: research

Long-term Outcomes of refactory Idiopathic Intracranial Hypertension with cerebral venous sinus stenosis After Endovascular Stenting.
Conclusions Our data suggest that stenting may be a promising therapeutic option for IIH with cerebral venous sinus stenosis of non thrombotic, non external compression . The majority of patients may get longer-term positive outcomes with stenting. PMID: 30727893 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 6, 2019 Category: Neurology Authors: Xu Y, Meng R, Rajah GB, Ding Y, Wu Y, Wu Y, Ji K, Wu C, Zhao W, Ji X Tags: Curr Neurovasc Res Source Type: research

Autophagy-Inhibition potentiates cell death and its Activation by trehalose does not protect hippocampal HT22 neurons against cell death induced by ER-Stress.
Abstract ER stress leads to the activation of two protein degradation pathways, the ubiquitin-proteasome via ER-associated degradation and lysosome-mediated protein degradation via autophagy. ER-associated degradation involves translocation of unfolded ER proteins to the cytosol where they are ubiquitinated and degraded by the proteasome. When the accumulation of misfolded or unfolded proteins excels the ER capacity, autophagy can be activated in order to degrade accumulated proteins and thus attenuate ER stress. Autophagy is the process by which cellular macromolecules and organelles components are sequestered wi...
Source: Current Neurovascular Research - January 31, 2019 Category: Neurology Authors: Halbe L, Rami A Tags: Curr Neurovasc Res Source Type: research

Intracranial aneurysms in sickle cell disease: A systematic review and case-control study.
e U Abstract BACKGROUND: The exact causes of intracranial aneurysms (IAs) are still unknown. However, certain diseases are known to be associated with IAs. OBJECTIVE: To analyze the differences in IA characteristics in the general population and in individuals with sickle-cell disease (SCD). METHODS: We systematically searched PubMed, Scopus, Web of Science, and Cochrane Library for data on SCD patients with IAs. We compared IA characteristics of SCD patients with those from 2451 healthy IA carriers from our observational cohort. RESULTS: 129 SCD patients with IAs were identified in 42 studies. The ...
Source: Current Neurovascular Research - January 31, 2019 Category: Neurology Authors: Jabbarli R, Dinger TF, Pierscianek D, Oppong MD, Chen B, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Sure U Tags: Curr Neurovasc Res Source Type: research

Current medical and surgical stroke prevention therapies for patients with carotid artery stenosis.
and M Abstract Carotid artery stenosis (CAS) is a marker of systemic atherosclerosis and patients with CAS are at high risk of vascular events in multiple vascular locations, including ipsilateral ischemic stroke. Both medical and surgical therapies have been demonstrated effective in reducing this risk. The optimal management for patients with asymptomatic carotid artery stenosis remains controversial. In patients with symptomatic CAS ≥70%, CEA has been demonstrated to reduce the risk of stroke. With risk of recurrent stroke being particularly high in the first 2 weeks after first event, CEA or carotid angiopl...
Source: Current Neurovascular Research - January 31, 2019 Category: Neurology Authors: Jusufovic M, Skagen K, Krohg-Sørensen K, Skjelland M Tags: Curr Neurovasc Res Source Type: research

Glucose levels and outcome after primary intraventricular hemorrhage.
Abstract OBJECTIVES: Hyperglycemia is reported to be associated with poor outcome in patients with spontaneous intracerebral hemorrhage (ICH), but the association between blood glucose level and outcomes in primary intraventricular hemorrhage (PIVH) remains unclear. We sought to identify the parameters associated with admission hyperglycemia and analyze the impact of hyperglycemia on clinical outcome in patients with PIVH. METHODS: Patients admitted to Department of Neurosurgery, West China Hospital with PIVH between 2010 and 2016 were retrospectively included in our study. Clinical, radiographic, and laborat...
Source: Current Neurovascular Research - January 31, 2019 Category: Neurology Authors: Guo R, Chen R, You C, Ma L, Li H, Fang Y Tags: Curr Neurovasc Res Source Type: research

Ameliorative effect of Phosphodiesterase-5 inhibitor in Rat model of Vascular Dementia.
Abstract Cerebral hypoperfusion has been associated with increased risk of vascular dementia (VaD). The present study investigates the potential of Tadalafil, a phosphodiesterase-5 inhibitor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced VaD. Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. Morris water-maze (MWM) test (7thday onwards post-surgery) was employed to assess learning and memory whereby escape latency time, time spent in target quadrant, Path length and average swim speed taken as important parameters. Endothelial dysfunction was assessed in isol...
Source: Current Neurovascular Research - January 30, 2019 Category: Neurology Authors: Bhatia P, Singh N Tags: Curr Neurovasc Res Source Type: research

Basilar Apex Aneurysms in the Setting of Carotid Artery Stenosis: Case Series and Angiographic Anatomic Study.
CONCLUSION: Changes in the cervical carotid arteries may lead to blood flow alterations in the posterior circulation that increase the propensity for BAA formation. Posterior circulation imaging can be considered in CAS patients to screen for BAA. PMID: 30706810 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - January 29, 2019 Category: Neurology Authors: Rosenbaum MD, Heiferman DM, Raslan OA, Martin B, Dominguez JF, de la Peña PM, Ashley WW, Rosenblum JD, Germanwala AV Tags: Curr Neurovasc Res Source Type: research

Changes in Cognition, Depression and Quality of Life after Carotid Stenosis Treatment.
The objective of this study was to assess changes in cognitive function, depressive symptoms and health-related quality of life (HRQoL) after CAS revascularisation and best medical treatment (BMT). METHODS: Study involved 213 patients with severe (≥70%) CAS who underwent assessment of cognitive function using Montreal Cognitive Assessment scale (MoCA), depressive symptoms - using Patient Health Questionnaire-9 (PHQ-9) and HRQoL - using Medical Outcome Survey Short Form version 2 (SF-36v2). The assessment was performed before carotid endarterectomy (CEA), n=159, percutaneous transluminal angioplasty (PTA), n=29 or B...
Source: Current Neurovascular Research - January 29, 2019 Category: Neurology Authors: Pucite E, Krievina I, Miglane E, Erts R, Krievins D, Millers A Tags: Curr Neurovasc Res Source Type: research

Elevated inflammatory parameter levels negatively correlate with populations of circulating stem cells (CD133+), early endothelial progenitor cells.
Abstract BACKGROUND: Endothelial progenitor cells (EPCs) are important players in neovascularization, mobilized through signalling by angiogenic growth factors (AGFs) such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). In vitro, inflammatory parameters impair the function and influence of EPCs on AGFs. However, this connection is not clear in vivo. To understand the mechanisms of augmented arteriogenesis and angiogenesis in acute ischemic stroke (AIS) patients, we investigated whether circulating stem cells (CD133+), early endothelial progenitor cells (CD133+/VEGFR2+), and endothe...
Source: Current Neurovascular Research - January 29, 2019 Category: Neurology Authors: Golab-Janowska M, Paczkowska E, Machalinski B, Kotlega D, Meller A, Nowacki P, Krzysztof S, Pawel W Tags: Curr Neurovasc Res Source Type: research

Alanine aminotransferase predicts outcomes in elderly patients with aneurysmal subarachnoid hemorrhage.
Abstract OBJECTIVE: With the aging of the world population, a growing number of elderly patients suffered from aneurysmal subarachnoid hemorrhage (aSAH). We aim to investigate the potential association between plasma ALT level and clinical complications of elderly aSAH patients, and explore its predictive value for clinical outcomes of elderly aSAH patients. PATIENTS AND METHODS: Between January 2013 and March 2018, 152 elderly aSAH patients were analyzed in this study. Clinical information, imaging findings and laboratory data were reviewed. According to the Glasgow Outcome Scale (GOS), clinical outcomes at ...
Source: Current Neurovascular Research - January 29, 2019 Category: Neurology Authors: Zheng J, Xu R, Guo Z, Sun X Tags: Curr Neurovasc Res Source Type: research