Carbon Monoxide Releasing Molecule-3 (CORM-3) Regulates Microglia Activity, Prevents Neuronal Injury, and Improves Memory Function Dur-ing Radiation Induced Brain Injury.
CONCLUSION: CORM-3 could effectively improve the inflammatory response induced by activation of the MG, reduce neu-ronal apoptosis, promote neural regeneration, and improve the learning and memory performance of mice after radiation. PMID: 32748746 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 30, 2020 Category: Neurology Authors: Lu K, Wu WJ, Zhang C, Zhu YL, Zhong JQ, Li J Tags: Curr Neurovasc Res Source Type: research

LncRNA SNHG12 improves cerebral ischemic-reperfusion injury by activating SIRT1/FOXO3a pathway through inhibition of autophagy and oxidative stress.
CONCLUSION: In conclusion, lncRNA SNHG12 increased cell activity and inhibited oxidative stress through inhibition of SIRT1/FOXO3a signaling-mediated autophagy in HT22 cells of I/R model. This study might provide new potential therapeutic targets for further investigating the mechanisms in cerebral I/R injury and provide. PMID: 32718291 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 27, 2020 Category: Neurology Authors: Wu Y, Huang Y, Cai J, Zhang D, Liu S, Pang B Tags: Curr Neurovasc Res Source Type: research

Neurological Complications in COVID-19 Patients and its Implications for Associated Mortality.
Abstract Coronavirus is an enveloped, non-segmented, positive-polarity and single-stranded RNA virus. It has four types genera that infect mammals and birds, with only alpha and beta types found to affect humans with varying severity. A specific clade of beta coronaviruses are reported as lethal zoonotic viruses and have created major epidemic troubles, starting with the severe acute respiratory syndrome (SARS) in 2002, then the Middle East respiratory syndrome (MERS) in 2012, and lastly Coronavirus Disease 2019 (COVID-19) in 2019. However, many neurological complications reported in COVID19 patients have highligh...
Source: Current Neurovascular Research - July 27, 2020 Category: Neurology Authors: AboTaleb HA Tags: Curr Neurovasc Res Source Type: research

Addressing Alzheimer's Disease and Cognitive Loss Through Autophagy.
PMID: 32693767 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 21, 2020 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
CONCLUSION: Our results indicate that DRP1 overexpression is a prospective radio-resistant phenotype in GBM. Therefore, DRP1 could be a potential target for improving the effectiveness of radiation therapy. PMID: 32576130 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - June 23, 2020 Category: Neurology Authors: Cheng WY, Chow KC, Chiao MT, Yang YC, Shen CC Tags: Curr Neurovasc Res Source Type: research

Adipokines as Potential Biomarkers in the Neurorehabilitation of Obese Stroke Patients.
CONCLUSIONS: Our data show the effectiveness of neurorehabilitation in modulating adipokines levels and suggest that leptin could assume the significance of biomarker of functional recovery. PMID: 32493188 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - June 3, 2020 Category: Neurology Authors: Ciancarelli I, Morone G, Iosa M, Paolucci S, Pignolo L, Tonin P, Cerasa A, Ciancarelli MGT Tags: Curr Neurovasc Res Source Type: research

Anti-vascular endothelial growth factor antibody limits vascular leakage and decreases subretinal fibrosis in a cynomolgus monkey choroidal neovascularization model.
CONCLUSION: In our established cynomolgus monkey CNV model, bevacizumab prevented blood leakage but could not completely suppress fibrosis. SHRM in the OCT images reflected retinal fibrous tissue in a laser-induced CNV monkey model. Our model might be useful for elucidating the pathology and development therapy for neovascularization or fibrosis. PMID: 32445455 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 23, 2020 Category: Neurology Authors: Inagaki S, Shimazawa M, Hamaguchi K, Otsu W, Araki T, Sasaki Y, Numata Y, Tsusaki H, Hara H Tags: Curr Neurovasc Res Source Type: research

Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
Abstract 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019. Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing. Recently, Mao et al. [1] investigated the penetration potential of SARS-CoV-2 into the central nervous system in 214 patients. They reported that 36.4% of the patients had some neurologic findings which are ranged from nonsp...
Source: Current Neurovascular Research - May 22, 2020 Category: Neurology Authors: Bostanciklioglu M, Temiz E Tags: Curr Neurovasc Res Source Type: research

Improved outcomes after reperfusion therapies for ischemic stroke: a "real-world" study in a developing country.
CONCLUSION: CRT led to better outcomes in patients with severe IS in Brazil. PMID: 32436830 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 20, 2020 Category: Neurology Authors: Schulz VC, de Magalhaes PSC, Carneiro CC, da Silva JIT, Silva VN, Guesser VV, Safanelli J, Diegoli H, Liberato RB, Lopes CCC, de Souza A, de França PHC, Conforto AB, Cabral NL Tags: Curr Neurovasc Res Source Type: research

Platelet-to-neutrophil ratio after Intravenous Thrombolysis Predicts Unfavorable Outcomes in Acute Ischemic Stroke.
This study aims to investigate the association between PNR and outcomes of AIS in intravenous thrombolysis (IVT) group. METHODS: Data of acute ischemic stroke patients who received intravenous thrombolysis from April 2015 to March 2019 were collected. We defined the PNR value at admission as pre-IVT PNR and after IVT within 24 h was defined as postIVT PNR. Clinical outcome indicators included early neurological deterioration(END), hemorrhagic transformation(HT), delayed neurological deterioration(DND), and poor 3-month outcome (3m-mRS> 2). RESULTS: A total of 581 patients were enrolled in the final analysis. T...
Source: Current Neurovascular Research - May 17, 2020 Category: Neurology Authors: Wang MQ, Sun YY, Wang Y, Yan XL, Jin H, Sun X, Zhang P, Zhu HJ, Guo ZN, Yang Y Tags: Curr Neurovasc Res Source Type: research

Association Between Neutrophil to Lymphocyte Ratio and Malignant Brain Edema in Patients With Large Hemispheric Infarction.
CONCLUSIONS: Higher NLR was associated with an increased risk of MBE in patients with LHI. PMID: 32416677 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 17, 2020 Category: Neurology Authors: Bai X, Wang C, Wang L, Jiang S, Zhang S, Liu M, Wu B Tags: Curr Neurovasc Res Source Type: research

Association of High-sensitivity C-reactive Protein with Patient Prognosis Following Mechanical Thrombectomy for Acute Ischemic Stroke.
Abstract OBJECTIVE: The aim of this investigation was to examine the association of hsCRP (high-sensitivity C-reactive protein) with outcomes and prognosis of patients who underwent mechanical thrombectomy (MT) for large vessel occlusion (LVO) after acute ischemic stroke (AIS). METHODS: A total of 404 patients were enrolled, and outcomes included unfavorable clinical outcome at three months (modified Rankin Scale, mRS scores 3-6), occurrence of symptomatic intracerebral hemorrhage (sICH) and hemorrhagic transformation (HT) of infarct. Receiver operating characteristic (ROC) curve analysis was performed to ide...
Source: Current Neurovascular Research - May 17, 2020 Category: Neurology Authors: Kim S, Yi HJ, Lee DH, Sung JH Tags: Curr Neurovasc Res Source Type: research

A Polyphenolic Complex Attenuates Inflammatory Response and Blood-Brain Barrier Disruption.
Abstract BACKGROUND: Cerebral ischemia causes strong inflammatory response. Neumentix is a dietary supplement containing 14.9% rosmarinic acid and 29.9% total phenolic content, which was proved to be beneficial against inflammatory response. Therefore, we investigated Neumentix's effect on anti-inflammatory and blood brain barrier (BBB) disruption in transient middle cerebral artery occlusion (tMCAO) model mice. METHODS: After the pretreatment of vehicle or Neumentix 134 mg/kg/d, intraperitoneal injection (i.p.) (containing rosmarinic acid 20mg/kg/d) for 14 days, mice were subjected to tMCAO for 60 min and ke...
Source: Current Neurovascular Research - May 16, 2020 Category: Neurology Authors: Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura E, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K Tags: Curr Neurovasc Res Source Type: research

The sodium channel Nav1.7 is involved in paclitaxel-induced peripheral neuropathy though ERK1/2 signaling in rats.
CONCLUSION: These results indicated that the sodium channel Nav1.7 in the DRG exerted an important function in paclitaxel-induced neuropathy, which was associated with ERK phosphorylation in neurons. PMID: 32407275 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 14, 2020 Category: Neurology Authors: Wang GJ, Zhang X, Huang LD, Xiao Y Tags: Curr Neurovasc Res Source Type: research

Association between coagulation function and spontaneous hemorrhagic transformation in acute ischemic stroke.
CONCLUSION: Not the whole process of coagulation function is associated with spontaneous HT. Prolonged TT, which may indicate an extension of the last step of the coagulation process, is independently and inversely associated with spontaneous HT in patients with acute ischemic stroke. PMID: 32407276 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 14, 2020 Category: Neurology Authors: Ye C, Wang Y, Song Q, Liu J, Wei C, Liu M Tags: Curr Neurovasc Res Source Type: research

Brivaracetam prevents the over-expression of synaptic vesicle protein 2A and rescues the deficits of hippocampal Long-term potentiation in vivo in chronic temporal lobe epilepsy rats.
CONCLUSION: BRV treatment ameliorated the over-expression of SV2A in hippocampus and rescued the synaptic dysfunction in epileptic rats. These results identify the neuroprotective effect of BRV on TLE model. PMID: 32407277 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 14, 2020 Category: Neurology Authors: Ge YX, Lin YY, Bi QQ, Chen YJ Tags: Curr Neurovasc Res Source Type: research

Impact of HbA1C (glycated hemoglobin) and glucose on outcomes of mechanical thrombectomy in patients with large artery occlusion.
This study evaluated the relationship between HbA1c (glycated hemoglobin), admission serum glucose levels and outcomes in patients with large artery occlusion (LAO) treated with mechanical thrombectomy (MT). METHODS: A total of 413 patients were enrolled, and the following outcomes were reviewed: successful recanalization, symptomatic hemorrhage, favorable outcome (modified Rankin Scale, mRS scores of 0-2), and mortality at 3 months. Receiver operating characteristic (ROC) curve analysis was undertaken to identify the cutoff values for HbA1C and glucose to discriminate between favorable and unfavorable outcome. The as...
Source: Current Neurovascular Research - May 14, 2020 Category: Neurology Authors: Kim JG, Yi HJ, Lee DH, Sung JH Tags: Curr Neurovasc Res Source Type: research

Serum albumin as a potential predictor of pneumonia after acute ischemic stroke.
Abstract BACKGROUND: Serum albumin level is associated with infection after stroke, but whether albumin predicts poststroke pneumonia is unclear. Here we evaluated the potential relationship between albumin level and pneumonia in patients with acute ischemic stroke (AIS). METHODS: A consecutive sample of 798 AIS patients who were admitted to West China Hospital within 24 h after onset between 2017 and 2018 were retrospectively analyzed. Blood was collected on admission and assayed for serum albumin. Univariate analyses, multivariate logistic regression, and stratified logistic regression were performed to ide...
Source: Current Neurovascular Research - May 14, 2020 Category: Neurology Authors: Yang X, Wang L, Zheng L, Wu J, Liu J, Hao Z, Zhang S, Wu B, Liu M, Wang D Tags: Curr Neurovasc Res Source Type: research

Low-dose sevoflurane attenuates cardiopulmonary bypass (CPB)-induced postoperative cognitive dysfunction (POCD) by regulating hippocampus apoptosis via PI3K/AKT pathway.
CONCLUSION: Taken together, low-dose sevoflurane attenuated CPB-induced POCD by inhibiting hippocampus apoptosis through activating PI3K/AKT signal pathway. PMID: 32400333 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 12, 2020 Category: Neurology Authors: Qin J, Ma Q, Ma D Tags: Curr Neurovasc Res Source Type: research

MicroR-26b targets high mobility group, AT-hook 2 to ameliorate myocardial infarction-induced fibrosis by suppression cardiac fibroblasts activation.
Abstract BACKGROUND: Myocardial fibrosis (MF) is an important physiological change after myocardial infarction (MI). MicroRNA-26b (MiR-26b) has a certain inhibitory effect on pulmonary fibrosis. However, the role of miR-26b in MI-induced MF rats and underlying molecular mechanisms remain unknown. MATERIAL AND METHODS: Forty male Sprague Dawley (SD) rats weighing 200-250g were divided into four groups (n=10): Sham group, MF group, MF + negative control (NC) agomir group and MF+miR-26b agomir group. Cardiac fibroblasts were isolated from cardiac tissue. Fibrosis levels were detected by MASSON staining, while ex...
Source: Current Neurovascular Research - May 5, 2020 Category: Neurology Authors: Chen X, Ding Z, Li T, Jiang W, Zhang J, Deng X Tags: Curr Neurovasc Res Source Type: research

Upregulation of miR-496 rescues propofol-induced neurotoxicity by targeting Rho Associated Coiled-Coil Containing Protein Kinase 2 (ROCK2) in prefrontal cortical neurons.
CONCLUSION: miR-496 was decreased in PFC neurons treated with propofol, and overexpression of miR-496 attenuated propofol-induced neurotoxicity by targeting ROCK2. miR-496 and ROCK2 may be promising targets for protecting propofol-induced neurotoxicity. PMID: 32370715 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - May 5, 2020 Category: Neurology Authors: Mao Z, Wang W, Gong H, Wu Y, Zhang Y, Wang X Tags: Curr Neurovasc Res Source Type: research

The mechanistic target of rapamycin (mTOR): Novel Considerations as an Antiviral Treatment and Possibilities for COVID-19.
Abstract As a rapidly developing etiology of a global disease, the -coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic leading to coronavirus disease 2019 (COVID-19) and has been declared by the World Health Organization as a Public Health Emergency of International Concern. To date, no definitive treatment or vaccine application exists for COVID-19. Although new investigations seek to repurpose existing antiviral treatments for COVID-19, innovative treatment strategies not normally considered to have antiviral capabilities may be critical as well to address this global concern. One such a...
Source: Current Neurovascular Research - April 25, 2020 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Red blood cell indices in relation to post-stroke psychiatric disorders: a longitudinal study in a follow-up stroke clinic.
CONCLUSION: The risks of PSD and PSA increased substantially 3 months beyond stroke onset. Of the RBC indices, higher MCV showed an independent positive association with PSD. PMID: 32324513 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 22, 2020 Category: Neurology Authors: Wang H, Gong L, Xia X, Dong Q, Jin A, Gu Y, Zhao Y, Liu X Tags: Curr Neurovasc Res Source Type: research

Determinants of Use of Long-term Continuous Electrocardiographic Monitoring for Acute Ischemic Stroke Patients without Atrial Fibrillation at Baseline.
CONCLUSIONS: When selecting the high-risk group of patients (with an NIHSS score> 12 and age> 64.5 years, or with an NIHSS score ≤ 12, age> 71.5 years, and triglyceride level ≤ 61.5 mg/dL) according to the CART model, the detection rate of paroxysmal AF was approximately double in the acute ischemic stroke patients without AF at baseline. PMID: 32324514 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 22, 2020 Category: Neurology Authors: Lee JD, Huang YC, Lee M, Lee TH, Kuo YW, Hu YH, Ovbiagele B Tags: Curr Neurovasc Res Source Type: research

Neuromodulation of memory formation and extinction.
Abstract Memory retrieval is mediated by discharges of acetylcholine, glutamate, gamma-aminobutyric acid, norepinephrine, and serotonin/5-hydroxytryptamine circuits. These projections and memory interact through engram circuits, neurobiological traces of memory. Increased excitability in engram circuits of medial prefrontal cortex and hippocampus results in remote and recent memory retrievals, respectively. However, due to degenerated neurotransmitter projections, the excitability state of engram circuits is decreased in the patient with dementia; and thus, acquired-memory cannot be retrieved by natural cues. Here...
Source: Current Neurovascular Research - April 21, 2020 Category: Neurology Authors: Bostancıklıoğlu M Tags: Curr Neurovasc Res Source Type: research

Pharmacological inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study.
CONCLUSION: This study confirms the ameliorative effect of TRPM2 channel inhibitor in the diabetes-induced cognitive deficits. Inhibition of TRPM2 channels reduces the calcium associated downstream signaling and showed a neuroprotective effect of TRPM2 channels in diabetes-induced cognitive impairment. PMID: 32294037 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 15, 2020 Category: Neurology Authors: Thapak P, Bishnoi M, Sharma SS Tags: Curr Neurovasc Res Source Type: research

Pathogenic mechanisms of a stroke-like attack elicited by epidural steroid injection therapy.
This article dissects the potential pathogenic mechanisms at a neurovascular unit. Noticeably, a schematic provides an explanation of how emboli formed by particulate steroids elicit either hemorrhagic or ischemic lesion. In addition, development of a rat model with intravertebral artery steroid injection is a proposal to address the unmet need in evaluating steroids and vascular injury in ESI. PMID: 32294038 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 15, 2020 Category: Neurology Authors: He Z Tags: Curr Neurovasc Res Source Type: research

MiR-485-5p promotes neuron survival through mediating Rac1/Notch2 signaling pathway after cerebral ischemia/reperfusion.
CONCLUSION: This study showed that miR-485-5p protected cells following I/R injury via targeting Rac1/Notch2 signaling, suggesting that targeted upregulation of miR-485-5p might be a promising therapeutic option for the protection against I/R injury. PMID: 32294039 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 15, 2020 Category: Neurology Authors: Chen X, Zhang S, Shi P, Su Y, Zhang D, Li N Tags: Curr Neurovasc Res Source Type: research

Overexpression of miR-26a-5p suppresses Tau phosphorylation and A β accumulation in Alzheimer's disease mice by targeting DYRK1A.
CONCLUSION: Overexpression of miR-26a-5p could repress Tau phosphorylation and Aβ accumulation via down-regulating DYRK1A level in AD mice. PMID: 32286945 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 14, 2020 Category: Neurology Authors: Liu Y, Wang L, Xie F, Wang X, Hou Y, Wang X, Liu J Tags: Curr Neurovasc Res Source Type: research

Donepezil improves gait performance in patients with an acute cerebral infarction: a prospective observational cohort study.
This study aimed to explore the influence factors of gait performance and investigate whether donepezil could improve gait performance in patients with an acute cerebral infarction. METHODS: A total of 107 patients who experienced unilateral paresis after an acute cerebral infarction incident were enrolled in this prospectively observational study. Participants underwent 3-month assessment. At the study's conclusion, patients were divided into 2 groups-those received daily donepezil (observation Group) and those not (Control Group). RESULTS: There was significant difference (t=3.269, p=0.001) of Wisconsin Gait Sc...
Source: Current Neurovascular Research - April 13, 2020 Category: Neurology Authors: Lin YY, Guo SJ, Quan H, Zhao YX, Huang DY Tags: Curr Neurovasc Res Source Type: research

Riluzole Exhibits No Therapeutic Efficacy On a Transgenic Rat model of Amyotrophic Lateral Sclerosis.
CONCLUSION: These findings indicate that transgenic rats recapitulate the basic neurological and neuropathological characteristics of human ALS, while Riluzole treatment can not halt the development of the behavioral and histopathological phenotypes in this new transgenic rodent model of ALS. PMID: 32271694 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 9, 2020 Category: Neurology Authors: Chen S, Liao Q, Lu K, Zhou J, Huang C, Bi F Tags: Curr Neurovasc Res Source Type: research

Dynamic change of neutrophil to lymphocyte ratios and infection in patients with acute ischemic stroke.
CONCLUSION: Increased NLR around 36 h after stroke was a predictor of infection in patients with acute ischemic stroke. The increased NLR value was associated with a higher risk of 3-month death, which was independent of poststroke infection. PMID: 32268864 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 7, 2020 Category: Neurology Authors: Wang L, Guo W, Wang C, Yang X, Hao Z, Wu S, Zhang S, Wu B, Liu M Tags: Curr Neurovasc Res Source Type: research

Heightened Attention for Wnt Signaling in Diabetes Mellitus.
PMID: 32216737 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - March 27, 2020 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Prospects and Perspectives for WISP1 (CCN4) in Diabetes Mellitus.
Abstract The prevalence of diabetes mellitus (DM) continues to increase throughout the world. In the United States (US) alone, approximately ten percent of the population is diagnosed with DM and another thirty-five percent of the population is considered to have prediabetes. Yet, current treatments for DM are limited and can fail to block the progression of multi-organ failure over time. Wnt1 inducible signaling pathway protein 1 (WISP1), also known as CCN4, is a matricellular protein that offers exceptional promise to address underlying disease progression and develop innovative therapies for DM. WISP1 holds an ...
Source: Current Neurovascular Research - March 27, 2020 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Knockdown of miR-124 reduces depression-like behavior in rats by targeting CREB1 and BDNF.
CONCLUSION: Knockdown of miR-124 can improve depression-like behavior in CUMS-induced depressive rats, which may be related at least in part to the up-regulation of CREB1 and BDNF expression in the hippocampus. PMID: 32189593 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - March 19, 2020 Category: Neurology Authors: Yang W, Liu M, Zhang Q, Zhang J, Chen J, Suo L, Chen Q Tags: Curr Neurovasc Res Source Type: research

Curcumin attenuates cerebral ischemia-reperfusion injury through regulating mitophagy and preserving mitochondrial function.
CONCLUSION: In conclusion, our results suggest that curcumin protects against cerebral I/R injury by improving mitophagy and preserving mitochondrial function. PMID: 32096742 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 25, 2020 Category: Neurology Authors: Wang W, Xu J Tags: Curr Neurovasc Res Source Type: research

Dexmedetomidine pretreatment improves lipopolysaccharide-induced iron homeostasis disorder in aged mice.
CONCLUSION: Dexmedetomidine has no effect on iron metabolism pathway, but it can improve the cognitive decline and the iron disorder by reducing neuroinflammation and oxidative stress. The research indicates that dexmedetomidine plays a neuroprotective role. PMID: 32065090 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 16, 2020 Category: Neurology Authors: Guo F, Kang J, Tan J, Wang Y, Jia L, Xu H Tags: Curr Neurovasc Res Source Type: research

Mesenchymal stem cell-derived exosomes rescue oxygen-glucose deprivation-induced injury in endothelial cells.
CONCLUSION: Both MSCs and MSC-derived exosomes attenuated OGD-induced rat primary brain endothelial cell injury. These findings suggest that at least some of the protective effects of MSCs on endothelial cells are mediated by MSC-derived exosomes. PMID: 32056526 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 13, 2020 Category: Neurology Authors: Kong LY, Liang MY, Liu JP, Lai P, Ye JS, Zhang ZX, Du ZM, Yu JJ, Gu L, Xie FC, Tang ZX, Liu ZY Tags: Curr Neurovasc Res Source Type: research

Isoflurane preconditioning protects the myocardium against ischemia and reperfusion injury by upregulating GRM1 expression.
CONCLUSION: The results of the present study have demonstrated that the expression of GRM1 provides a protective role in ISO preconditioning against I/R-induced myocardial infarction by reduce the oxidative stress and DNA damage. PMID: 32048972 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 11, 2020 Category: Neurology Authors: Huang H, Qing X, Li H Tags: Curr Neurovasc Res Source Type: research

New Challenges and Strategies for Cardiac Disease: Autophagy, mTOR, and AMP-Activated Protein Kinase.
PMID: 32036783 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 7, 2020 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

MicroRNA-582-5p reduces propofol-induced apoptosis in developing neurons by targeting ROCK1.
CONCLUSION: Taken together, these findings suggest that miR-582-5p alleviated propofol-induced apoptosis of newborn rat neurons by inhibiting ROCK1. PMID: 32031069 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 7, 2020 Category: Neurology Authors: Zhang Z, Xu Y, Chi S, Cui L Tags: Curr Neurovasc Res Source Type: research

Association between preoperative midline shift growing rate and outcomes of decompressive craniectomy in patients with malignant middle cerebral artery infarction.
CONCLUSION: Higher preoperative midline shift growing rate was associated with inadequate decompression of decompressive craniectomy in patients with malignant middle cerebral artery infarction. PMID: 32031070 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 7, 2020 Category: Neurology Authors: Yuan R, Wu S, Cheng Y, Ye K, Hao Z, Zhang S, Liu Y, Liu M Tags: Curr Neurovasc Res Source Type: research

Nanocurcumin inhibits angiogenesis via down-regulating hif1a/vegfa signaling in Zebrafish.
Abstract Curcumin has anti-inflammatory, antioxidant and anticancer properties. Despite the considerable promise that curcumin is an efficacious and safe compound for multiple medicinal benefits, there are some demerits with respect to the therapeutic effectiveness of curcumin, namely, poor stability and solubility, and its role in angiogenesis in vivo is still not yet clear. More recently, the approach of biodegradable polymer nanoparticles has been developed. This offers promise for therapeutic effectiveness of curcumin by increasing its bioavailability, solubility and retention time. Here, we compared the medic...
Source: Current Neurovascular Research - February 7, 2020 Category: Neurology Authors: Cao Z, He S, Peng Y, Liao X, Lu H Tags: Curr Neurovasc Res Source Type: research

Early Age of Migraine Onset is Independently Related to Cognitive Decline and Symptoms of Anxiety Affect Quality of Life.
Abstract BACKGROUND: People with migraine experience cognitive decline more often than healthy controls, resulting in a significant functional impact. Early identifying influencing factors that contribute to cognitive decline in migraineurs is crucial for timely intervention. Although migraine may onset early in childhood and early onset migraine is related to significant disability, there is no research investigating the association between age of migraine onset and migraineurs' cognitive decline. Therefore we aim to explore possible factors that correlate to cognitive function of migraineurs, especially focus on...
Source: Current Neurovascular Research - February 7, 2020 Category: Neurology Authors: He L, Bao J, Ma M, Dong S, Gao L, Li C, Cui C, Chen N, Zhang Y Tags: Curr Neurovasc Res Source Type: research

MicroRNA (miR)-429 promotes inflammatory injury by targeting kruppel-like factor 4 (KLF4) in neonatal pneumonia.
CONCLUSION: MiR-429 promotes inflammatory injury, apoptosis and activates NF-κB signaling pathway by targeting KLF4 in neonatal pneumonia, and then these results provide evidence for clinical diagnosis and treatment for neonatal pneumonia. PMID: 32003671 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - January 28, 2020 Category: Neurology Authors: Zhang L, Yan HL, Wang H, Wang L, Bai B, Ma Y, Tie Y, Xi Z Tags: Curr Neurovasc Res Source Type: research

MiR-335-5p inhibits β-Amyloid (Aβ) accumulation to attenuate cognitive deficits through targeting c-jun-N-terminal kinase 3 in alzheimer's disease.
CONCLUSION: The results revealed that the increased JNK3 expression, negatively regulated by miR-335-5p, maybe a potential mechanism that contributes to Aβ accumulation and AD progression, indicating a novel approach for AD treatment. PMID: 32003672 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - January 28, 2020 Category: Neurology Authors: Wang D, Fei Z, Luo S, Wang H Tags: Curr Neurovasc Res Source Type: research

Forkhead box O1-p21 mediates macrophage polarization in postoperative cognitive dysfunction induced by sevoflurane.
Abstract PURPOSE: The current study was conducted in order to investigate the role of Forkhead box O1 and p21-mediated macrophage polarization in postoperative cognitive dysfunction induced by sevoflurane. METHODS: There involved a total of 30 healthy mice that were randomly divided into two groups: control group (without any treatment) and anaesthesia group (treated with sevoflurane inhalation). The effects of sevoflurane on cognitive function (memory) in mice were studied by trace fear conditioned reflex, and the effects of systemic inflammation and behavior after operation were measured by enzyme-linked im...
Source: Current Neurovascular Research - January 28, 2020 Category: Neurology Authors: Fu JB, Wang ZH, Ren YY Tags: Curr Neurovasc Res Source Type: research

Evaluation of Two Fast Virtual Stenting Algorithms for Intracranial Aneurysm Flow Diversion.
In conclusion, modeling stent expansion is critical for preventing unrealistic bulging effects and thus should be considered in virtual FD deployment algorithms. Due to its high computational efficiency and superior accuracy, the VSW algorithm is a better candidate for implementation into a bedside clinical tool for FD deployment simulation. PMID: 31987021 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - January 20, 2020 Category: Neurology Authors: Lamooki SR, Tutino VM, Paliwal N, Damiano RJ, Waqas M, Nagesh SSV, Rajabzadeh-Oghaz H, Vakharia K, Siddiqui AH, Meng H Tags: Curr Neurovasc Res Source Type: research

miR-340 reduces accumulation of amyloid- β through targeting BACE1 (β-site amyloid precursor protein cleaving enzyme 1) in Alzheimer' s disease.
CONCLUSION: MiR-340 was down-regulated in AD and educed accumulation of amyloid-βthrough targeting BACE1, suggesting a potential therapeutic target for AD. PMID: 31957613 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - January 16, 2020 Category: Neurology Authors: Tan X, Luo Y, Pi D, Xia L, Li Z, Tu Q Tags: Curr Neurovasc Res Source Type: research

Propofol pretreatment prevents oxygen-glucose deprivation/reoxygenation(OGD/R)-induced inflammation through nuclear transcription factor κB (NF-κB) pathway in neuroblastoma cells.
CONCLUSION: Our work demonstrated for the first time that propofol pretreatment ameliorated OGD/R induced inflammation via NF-κB pathway modulation in mouse neuroblastoma N2A cells, indicating propofol might be considered as a potential therapeutic approach to reduce inflammation in neuroblastoma. PMID: 31880261 [PubMed - as supplied by publisher] (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - December 26, 2019 Category: Neurology Authors: Hu F, Jiang J, Yu G, Zang H, Sun H Tags: Curr Neurovasc Res Source Type: research