The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy
This study aims to investigate the correlation between cerebral blood flow (CBF) values and neonatal behavioral neurological assessment (NBNA) in hypoxic-ischemic encephalopathy (HIE), the relationship between early CBF value changes and the prognosis of neonatal HIE, and the consistency between the clinical grading and magnetic resonance (MR) grading of HIE.METHODS: Forty neonates with HIE were scanned using the three-dimensional arterial spin labeling (ASL) sequencing of the cranial magnetic resonance imaging (MRI). These newborns were classified as having mild, moderate and severe HIE, according to the clinical grading,...
Source: Current Neurovascular Research - September 21, 2021 Category: Neurology Authors: Jianing Wang Jia Li Xiaoping Yin Huan Zhou Yating Zheng Xi Ma Huaijun Liu Source Type: research

NEP1-40-overexpressing neural stem cells enhance axon regeneration by inhibiting Nogo-A/NgR1 signaling pathway
CONCLUSION: NEP1-40 overexpression enhanced the ability of NSCs differentiation into neurons and promoted axon regeneration by inhibiting the Nogo-A/NgR1 signaling pathway. This study provides an alternative gene modified transplantation NSCs for the SCI treatment.PMID:34544340 | DOI:10.2174/1567202618666210920115716 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 21, 2021 Category: Neurology Authors: Bi Zhang Dalin Wang Xusheng Li Shengsen Yang Haifeng Yuan Source Type: research

The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy
This study aims to investigate the correlation between cerebral blood flow (CBF) values and neonatal behavioral neurological assessment (NBNA) in hypoxic-ischemic encephalopathy (HIE), the relationship between early CBF value changes and the prognosis of neonatal HIE, and the consistency between the clinical grading and magnetic resonance (MR) grading of HIE.METHODS: Forty neonates with HIE were scanned using the three-dimensional arterial spin labeling (ASL) sequencing of the cranial magnetic resonance imaging (MRI). These newborns were classified as having mild, moderate and severe HIE, according to the clinical grading,...
Source: Current Neurovascular Research - September 21, 2021 Category: Neurology Authors: Jianing Wang Jia Li Xiaoping Yin Huan Zhou Yating Zheng Xi Ma Huaijun Liu Source Type: research

NEP1-40-overexpressing neural stem cells enhance axon regeneration by inhibiting Nogo-A/NgR1 signaling pathway
CONCLUSION: NEP1-40 overexpression enhanced the ability of NSCs differentiation into neurons and promoted axon regeneration by inhibiting the Nogo-A/NgR1 signaling pathway. This study provides an alternative gene modified transplantation NSCs for the SCI treatment.PMID:34544340 | DOI:10.2174/1567202618666210920115716 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 21, 2021 Category: Neurology Authors: Bi Zhang Dalin Wang Xusheng Li Shengsen Yang Haifeng Yuan Source Type: research

The value of arterial spin labeling imaging in the classification and prognostic evaluation of neonatal hypoxic-ischemic encephalopathy
This study aims to investigate the correlation between cerebral blood flow (CBF) values and neonatal behavioral neurological assessment (NBNA) in hypoxic-ischemic encephalopathy (HIE), the relationship between early CBF value changes and the prognosis of neonatal HIE, and the consistency between the clinical grading and magnetic resonance (MR) grading of HIE.METHODS: Forty neonates with HIE were scanned using the three-dimensional arterial spin labeling (ASL) sequencing of the cranial magnetic resonance imaging (MRI). These newborns were classified as having mild, moderate and severe HIE, according to the clinical grading,...
Source: Current Neurovascular Research - September 21, 2021 Category: Neurology Authors: Jianing Wang Jia Li Xiaoping Yin Huan Zhou Yating Zheng Xi Ma Huaijun Liu Source Type: research

NEP1-40-overexpressing neural stem cells enhance axon regeneration by inhibiting Nogo-A/NgR1 signaling pathway
CONCLUSION: NEP1-40 overexpression enhanced the ability of NSCs differentiation into neurons and promoted axon regeneration by inhibiting the Nogo-A/NgR1 signaling pathway. This study provides an alternative gene modified transplantation NSCs for the SCI treatment.PMID:34544340 | DOI:10.2174/1567202618666210920115716 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 21, 2021 Category: Neurology Authors: Bi Zhang Dalin Wang Xusheng Li Shengsen Yang Haifeng Yuan Source Type: research

Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-Resistant Epilepsy Induced by Lithium-Pilocarpine
CONCLUSION: Taken together, these correlations among drug resistance, seizure frequency, spatial memory impairment and MFS suggested the possibility of a common pathological mechanism. More studies are needed to clarify the underlying mechanism behind these correlations and the detailed role of MFS in epilepsy. The mechanism of mossy cell change may be an important target for the treatment of seizures, drug resistance and cognitive dysfunction in patients with epilepsy.PMID:34538230 | DOI:10.2174/1567202618666210917155408 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 20, 2021 Category: Neurology Authors: Jing Wu Likun Wang Yuanxin Huang Qian Wu Xingmei Luo Yinghui Li Siying Ren Guofeng Wu Source Type: research

Correlation between bispectral index and prognosis of patients with acute cerebral infarction
CONCLUSION: BIS directly reflects the degree of consciousness disturbance in ACI patients, and thus accurately predicts the prognosis, indicating potential application values of BIS in clinical practice.PMID:34538231 | DOI:10.2174/1567202618666210917164223 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 20, 2021 Category: Neurology Authors: Wei Qin Shumei Wang Lei Yang Junliang Yuan Shiqin Niu Wenli Hu Source Type: research

Cognitive Impairment and Mossy Fiber Sprouting in a Rat Model of Drug-Resistant Epilepsy Induced by Lithium-Pilocarpine
CONCLUSION: Taken together, these correlations among drug resistance, seizure frequency, spatial memory impairment and MFS suggested the possibility of a common pathological mechanism. More studies are needed to clarify the underlying mechanism behind these correlations and the detailed role of MFS in epilepsy. The mechanism of mossy cell change may be an important target for the treatment of seizures, drug resistance and cognitive dysfunction in patients with epilepsy.PMID:34538230 | DOI:10.2174/1567202618666210917155408 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 20, 2021 Category: Neurology Authors: Jing Wu Likun Wang Yuanxin Huang Qian Wu Xingmei Luo Yinghui Li Siying Ren Guofeng Wu Source Type: research

Correlation between bispectral index and prognosis of patients with acute cerebral infarction
CONCLUSION: BIS directly reflects the degree of consciousness disturbance in ACI patients, and thus accurately predicts the prognosis, indicating potential application values of BIS in clinical practice.PMID:34538231 | DOI:10.2174/1567202618666210917164223 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 20, 2021 Category: Neurology Authors: Wei Qin Shumei Wang Lei Yang Junliang Yuan Shiqin Niu Wenli Hu Source Type: research

Poly (Adenosine Diphosphate Ribose) Polymerase-1 Single Nucleotide Polymorphism In The 3'-Untranslated Region For Ischemic Stroke Risk Reduction
CONCLUSION: Single nucleotide polymorphism (SNP) rs8679 in PARP13'UTR can prevent ischemic stroke.PMID:34530710 | DOI:10.2174/1567202618666210916122553 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 17, 2021 Category: Neurology Authors: Lujun Gu Gangtao Xu Dinghua Liu Source Type: research

Feasibility and Efficacy of Low-profile Visual Intraluminal Support Device: a Single Center Five-year Experience
CONCLUSION: LVIS brand of stents is a safe, effective, and technically feasible treatment strategy for wide-neck intracranial aneurysms, with high deployment success and aneurysm obliteration rates.PMID:34515001 | DOI:10.2174/1567202618666210910123134 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 13, 2021 Category: Neurology Authors: Vitaliy Davidov Saeed Sadrameli Virendra Desai Jonathan Lee Ryan Austerman Amanda Jenson Zain Boghani Gavin Britz Orlando Diaz Richard P Klucznik Yi Jonathan Zhang Source Type: research

Feasibility and Efficacy of Low-profile Visual Intraluminal Support Device: a Single Center Five-year Experience
CONCLUSION: LVIS brand of stents is a safe, effective, and technically feasible treatment strategy for wide-neck intracranial aneurysms, with high deployment success and aneurysm obliteration rates.PMID:34515001 | DOI:10.2174/1567202618666210910123134 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 13, 2021 Category: Neurology Authors: Vitaliy Davidov Saeed Sadrameli Virendra Desai Jonathan Lee Ryan Austerman Amanda Jenson Zain Boghani Gavin Britz Orlando Diaz Richard P Klucznik Yi Jonathan Zhang Source Type: research

Feasibility and Efficacy of Low-profile Visual Intraluminal Support Device: a Single Center Five-year Experience
CONCLUSION: LVIS brand of stents is a safe, effective, and technically feasible treatment strategy for wide-neck intracranial aneurysms, with high deployment success and aneurysm obliteration rates.PMID:34515001 | DOI:10.2174/1567202618666210910123134 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 13, 2021 Category: Neurology Authors: Vitaliy Davidov Saeed Sadrameli Virendra Desai Jonathan Lee Ryan Austerman Amanda Jenson Zain Boghani Gavin Britz Orlando Diaz Richard P Klucznik Yi Jonathan Zhang Source Type: research

Feasibility and Efficacy of Low-profile Visual Intraluminal Support Device: a Single Center Five-year Experience
CONCLUSION: LVIS brand of stents is a safe, effective, and technically feasible treatment strategy for wide-neck intracranial aneurysms, with high deployment success and aneurysm obliteration rates.PMID:34515001 | DOI:10.2174/1567202618666210910123134 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 13, 2021 Category: Neurology Authors: Vitaliy Davidov Saeed Sadrameli Virendra Desai Jonathan Lee Ryan Austerman Amanda Jenson Zain Boghani Gavin Britz Orlando Diaz Richard P Klucznik Yi Jonathan Zhang Source Type: research

Feasibility and Efficacy of Low-profile Visual Intraluminal Support Device: a Single Center Five-year Experience
CONCLUSION: LVIS brand of stents is a safe, effective, and technically feasible treatment strategy for wide-neck intracranial aneurysms, with high deployment success and aneurysm obliteration rates.PMID:34515001 | DOI:10.2174/1567202618666210910123134 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - September 13, 2021 Category: Neurology Authors: Vitaliy Davidov Saeed Sadrameli Virendra Desai Jonathan Lee Ryan Austerman Amanda Jenson Zain Boghani Gavin Britz Orlando Diaz Richard P Klucznik Yi Jonathan Zhang Source Type: research

Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in Patients with Stroke after Intravenous Thrombolysis
Curr Neurovasc Res. 2021 Sep 6. doi: 10.2174/1567202618666210906142522. Online ahead of print.ABSTRACTBACKGROUND: The association between atrial fibrillation (AF) and the prognosis of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) is debated. Hypokalemia is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF on the prognosis of AIS patients following IVT.METHOD: AIS patients undergoing IVT were enrolled and divided into four groups: normokalemia and non-AF, normokalemia and AF, hypokalemia and non-AF, hypokalemia and AF. Logistic regression was applied...
Source: Current Neurovascular Research - September 7, 2021 Category: Neurology Authors: Li-Min Wei Cheng-Ye Zhou Wang-Qian Ge Jia-Sheng Huang Source Type: research

Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in Patients with Stroke after Intravenous Thrombolysis
Curr Neurovasc Res. 2021 Sep 6. doi: 10.2174/1567202618666210906142522. Online ahead of print.ABSTRACTBACKGROUND: The association between atrial fibrillation (AF) and the prognosis of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) is debated. Hypokalemia is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF on the prognosis of AIS patients following IVT.METHOD: AIS patients undergoing IVT were enrolled and divided into four groups: normokalemia and non-AF, normokalemia and AF, hypokalemia and non-AF, hypokalemia and AF. Logistic regression was applied...
Source: Current Neurovascular Research - September 7, 2021 Category: Neurology Authors: Li-Min Wei Cheng-Ye Zhou Wang-Qian Ge Jia-Sheng Huang Source Type: research

Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in Patients with Stroke after Intravenous Thrombolysis
Curr Neurovasc Res. 2021 Sep 6. doi: 10.2174/1567202618666210906142522. Online ahead of print.ABSTRACTBACKGROUND: The association between atrial fibrillation (AF) and the prognosis of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) is debated. Hypokalemia is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF on the prognosis of AIS patients following IVT.METHOD: AIS patients undergoing IVT were enrolled and divided into four groups: normokalemia and non-AF, normokalemia and AF, hypokalemia and non-AF, hypokalemia and AF. Logistic regression was applied...
Source: Current Neurovascular Research - September 7, 2021 Category: Neurology Authors: Li-Min Wei Cheng-Ye Zhou Wang-Qian Ge Jia-Sheng Huang Source Type: research

Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in Patients with Stroke after Intravenous Thrombolysis
Curr Neurovasc Res. 2021 Sep 6. doi: 10.2174/1567202618666210906142522. Online ahead of print.ABSTRACTBACKGROUND: The association between atrial fibrillation (AF) and the prognosis of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) is debated. Hypokalemia is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF on the prognosis of AIS patients following IVT.METHOD: AIS patients undergoing IVT were enrolled and divided into four groups: normokalemia and non-AF, normokalemia and AF, hypokalemia and non-AF, hypokalemia and AF. Logistic regression was applied...
Source: Current Neurovascular Research - September 7, 2021 Category: Neurology Authors: Li-Min Wei Cheng-Ye Zhou Wang-Qian Ge Jia-Sheng Huang Source Type: research

Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in Patients with Stroke after Intravenous Thrombolysis
Curr Neurovasc Res. 2021 Sep 6. doi: 10.2174/1567202618666210906142522. Online ahead of print.ABSTRACTBACKGROUND: The association between atrial fibrillation (AF) and the prognosis of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) is debated. Hypokalemia is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF on the prognosis of AIS patients following IVT.METHOD: AIS patients undergoing IVT were enrolled and divided into four groups: normokalemia and non-AF, normokalemia and AF, hypokalemia and non-AF, hypokalemia and AF. Logistic regression was applied...
Source: Current Neurovascular Research - September 7, 2021 Category: Neurology Authors: Li-Min Wei Cheng-Ye Zhou Wang-Qian Ge Jia-Sheng Huang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/ β-catenin signalling pathway
CONCLUSION: This study showed that the application of peptide5 maintained cell viability and permeability associated with rtPA treatment, revealing a possible pathway that could be exploited to limit rtPA-related endothelial cell injury during ischemic stroke. Furthermore, the altered Wnt/β-catenin signaling pathway demonstrated that signaling pathways associated with Cx43 might have potential applications in the future. This study may provide a new way to attenuate HT and assist the application of rtPA in ischemic stroke.PMID:34370635 | DOI:10.2174/1567202618666210809115305 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - August 9, 2021 Category: Neurology Authors: Weimin Ren Chuyi Huang Heling Chu Yuping Tang Xiaobo Yang Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Neutrophil-to-lymphocyte ratio predicts the outcome of cerebral venous thrombosis
Curr Neurovasc Res. 2021 Jul 26. doi: 10.2174/1567202618666210726122310. Online ahead of print.ABSTRACTBACKGROUND: Increasing evidences suggest that neutrophil-to- lymphocyte ratio (NLR) is an independent predictor of poor prognosis in patients with cardiovascular disease. However, the relationship between NLR and prognosis in patients with cerebral venous thrombosis (CVT) has not been studied.METHODS: Consecutive CVT patients from November 2011 through April 2019 were retrospectively identified. Poor outcome was defined as modified Rankin Scale (mRS) of 3-6. Multivariate regression analysis was conducted to assess the rel...
Source: Current Neurovascular Research - July 27, 2021 Category: Neurology Authors: Jiawei Zhao Kai Liu Shen Li Yuan Gao Lu Zhao Hongbing Liu Hui Fang Bo Song Yuming Xu Source Type: research

Sleep Disorders, Neurodegeneration, Glymphatic Pathways, and Circadian Rhythm Disruption
Curr Neurovasc Res. 2021 Jul 20. doi: 10.2174/1567202618666210720145728. Online ahead of print.NO ABSTRACTPMID:34303329 | DOI:10.2174/1567202618666210720145728 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 25, 2021 Category: Neurology Authors: Kenneth Maiese Source Type: research

Sleep Disorders, Neurodegeneration, Glymphatic Pathways, and Circadian Rhythm Disruption
Curr Neurovasc Res. 2021 Jul 20. doi: 10.2174/1567202618666210720145728. Online ahead of print.NO ABSTRACTPMID:34303329 | DOI:10.2174/1567202618666210720145728 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 25, 2021 Category: Neurology Authors: Kenneth Maiese Source Type: research

Plasma Homocysteine and Prognosis of Patients with Recanalization after Acute Basilar Artery Occlusion: An Analysis from the Acute Basilar Artery Occlusion Study (BASILAR) Nationwide Prospective Registry
CONCLUSION: Our analysis suggests that elevated plasma Hcy levels have predictive value for functional outcomes in patients with recanalization after acute BAO during the 90-day follow-up period, but not for mortality.PMID:34238192 | DOI:10.2174/1567202618666210708102502 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 9, 2021 Category: Neurology Authors: Xiangrong Sun Qian Yang Xinyue Ju Shenglin Wang Zhongming Qiu Hongfei Sang Wenjie Zi Qingwu Yang Guohui Jiang Source Type: research

Plasma Homocysteine and Prognosis of Patients with Recanalization after Acute Basilar Artery Occlusion: An Analysis from the Acute Basilar Artery Occlusion Study (BASILAR) Nationwide Prospective Registry
CONCLUSION: Our analysis suggests that elevated plasma Hcy levels have predictive value for functional outcomes in patients with recanalization after acute BAO during the 90-day follow-up period, but not for mortality.PMID:34238192 | DOI:10.2174/1567202618666210708102502 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 9, 2021 Category: Neurology Authors: Xiangrong Sun Qian Yang Xinyue Ju Shenglin Wang Zhongming Qiu Hongfei Sang Wenjie Zi Qingwu Yang Guohui Jiang Source Type: research

Plasma Homocysteine and Prognosis of Patients with Recanalization after Acute Basilar Artery Occlusion: An Analysis from the Acute Basilar Artery Occlusion Study (BASILAR) Nationwide Prospective Registry
CONCLUSION: Our analysis suggests that elevated plasma Hcy levels have predictive value for functional outcomes in patients with recanalization after acute BAO during the 90-day follow-up period, but not for mortality.PMID:34238192 | DOI:10.2174/1567202618666210708102502 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - July 9, 2021 Category: Neurology Authors: Xiangrong Sun Qian Yang Xinyue Ju Shenglin Wang Zhongming Qiu Hongfei Sang Wenjie Zi Qingwu Yang Guohui Jiang Source Type: research