Risk of Adverse Cardiovascular Outcomes in Postmenopausal Women with Inflammatory Bowel Disease
ConclusionsAmong postmenopausal women with IBD, risk of ischemic stroke may be higher than in non-IBD women. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 29, 2024 Category: Gastroenterology Source Type: research
Long-Term Accumulation of T Cytotoxic 1, T Cytotoxic 17, and T Cytotoxic 17/1 Cells in the Brain Contributes to Microglia-Mediated Chronic Neuroinflammation After Ischemic Stroke
AbstractPost-stroke neuroinflammation affects the damage and recovery of neurological functions. T cells including CD8+ T cells were present in the ipsilateral hemisphere in the subacute and late phases of ischemic stroke. However, the potential roles of CD8+ T cell subsets in the progression of neuroinflammation have not been characterized. In the current mouse transient middle cerebral artery occlusion model, we investigated the existence of CD8+ T cell subsets in the ipsilateral hemisphere in the subacute and late phases of stroke. We found that ipsilateral CD8+ T cells were present on post-stroke day 3 and increased on...
Source: NeuroMolecular Medicine - April 29, 2024 Category: Neurology Source Type: research
Risk of Adverse Cardiovascular Outcomes in Postmenopausal Women with Inflammatory Bowel Disease
ConclusionsAmong postmenopausal women with IBD, risk of ischemic stroke may be higher than in non-IBD women. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 29, 2024 Category: Gastroenterology Source Type: research
The obstetrical consequences of ischemic stroke in women of childbearing age
CONCLUSIONS: We observed no recurrence of IS during pregnancy. The study also highlighted that the risk of miscarriages was higher than general population and that of stillbirth should be further studied.PMID:38679658 | DOI:10.1007/s00404-024-07498-y (Source: Atherosclerosis)
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Jeremy David Helene Desmurs-Clavel Laura Mechtouff Anne Long Yesim Dargaud Judith Catella Source Type: research
Remnant cholesterol, LDL cholesterol, and apoB absolute mass changes explain results of the PROMINENT trial
CONCLUSIONS: Absolute mass changes in remnant cholesterol, LDL cholesterol, and apolipoprotein B can explain results of the PROMINENT trial. The 3 mg/dL (0.08 mmol/L) higher total atherogenic cholesterol together with 5 mg/dL (0.05 g/L) higher apolipoprotein B seem to explain the trend toward more ASCVD in the pemafibrate arm.PMID:38678642 | DOI:10.1016/j.atherosclerosis.2024.117556 (Source: Atherosclerosis)
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Takahito Doi Anne Langsted B ørge G Nordestgaard Source Type: research
Temporarily Reversing Warfarin With Low-Dose 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients Undergoing an Invasive Procedure
CONCLUSIONS AND RELEVANCE: Low-dose PCC4 appears to be a safe and effective temporary reversal strategy for patients with LVADs undergoing low-bleed risk elective procedures.PMID:38678311 | DOI:10.1177/10600280241248172 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 28, 2024 Category: Drugs & Pharmacology Authors: Byron Stevenson A Joshua Roberts William E Dager Source Type: research
Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke
Exp Neurol. 2024 Apr 26:114802. doi: 10.1016/j.expneurol.2024.114802. Online ahead of print.ABSTRACTPyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral circulation and mitigating ferroptosis in a murine model of middle cerebral artery occlusion (MCAO). However, the connection between ELA and neuronal pyroptosis remains further elucidation. Here, we observed an upregulation of ELA and APJ expression in both murine brain specimens and...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Nan Shen Lingqi Kong Xinyue Wang Yan Zhang Rui Li Chunrong Tao Guoping Wang Pengfei Xu Wei Hu Source Type: research
Temporarily Reversing Warfarin With Low-Dose 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients Undergoing an Invasive Procedure
CONCLUSIONS AND RELEVANCE: Low-dose PCC4 appears to be a safe and effective temporary reversal strategy for patients with LVADs undergoing low-bleed risk elective procedures.PMID:38678311 | DOI:10.1177/10600280241248172 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 28, 2024 Category: Drugs & Pharmacology Authors: Byron Stevenson A Joshua Roberts William E Dager Source Type: research
Elabela ameliorates neuronal pyroptosis and mitochondrial fission via APJ/ZBP1 signaling in ischemic stroke
Exp Neurol. 2024 Apr 26:114802. doi: 10.1016/j.expneurol.2024.114802. Online ahead of print.ABSTRACTPyroptosis signifies a significant form of programmed neuronal demise subsequent to ischemic stroke. In our prior investigations, we demonstrated that the Elabela (ELA)-Apelin receptor (APJ) axis alleviated neuronal death by improving collateral circulation and mitigating ferroptosis in a murine model of middle cerebral artery occlusion (MCAO). However, the connection between ELA and neuronal pyroptosis remains further elucidation. Here, we observed an upregulation of ELA and APJ expression in both murine brain specimens and...
Source: Experimental Neurology - April 28, 2024 Category: Neurology Authors: Nan Shen Lingqi Kong Xinyue Wang Yan Zhang Rui Li Chunrong Tao Guoping Wang Pengfei Xu Wei Hu Source Type: research
Integrating Bulk RNA and Single-Cell Sequencing Data Unveils Efferocytosis Patterns and ceRNA Network in Ischemic Stroke
This study explored the roles of inflammation and efferocytosis in IS with bioinformatics. Three Gene Expression Omnibus Series (GSE) (GSE137482-3 m, GSE137482-18 m, and GSE30655) were obtained from NCBI (National Center for Biotechnology Information) and GEO (Gene Expression Omnibus). Differentially expressed genes (DEGs) were processed for GSEA (Gene Set Enrichment Analysis), GO (Gene Ontology Functional Enrichment Analysis), and KEGG (Ky oto Encyclopedia of Genes and Genomes) pathway analyses. Efferocytosis-related genes were identified from the existing literature, following which the relationship between Differenti...
Source: Translational Stroke Research - April 28, 2024 Category: Neurology Source Type: research
Optimizing catheter centering enhances mechanical thrombectomy success: Performance difference in cases using novel macrowires versus traditional microwires
CONCLUSION: Large 0.018″ or 0.024″ OD guidewires better fill the lumen of the catheter and help to center the thrombectomy system in the vessel and navigate to the clot face. This leads to a reduction in procedure time and number of passes, and an increase in first pass success, especially when treating occlusions in the ICA.PMID:38676326 | DOI:10.1177/15910199241249212 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - April 27, 2024 Category: Radiology Authors: Ameer E Hassan Wondwossen G Tekle Hamzah Saei Source Type: research
Molecular Pathways of Vulnerable Carotid Plaques at Risk of Ischemic Stroke: A Narrative Review
Int J Mol Sci. 2024 Apr 15;25(8):4351. doi: 10.3390/ijms25084351.ABSTRACTThe concept of vulnerable carotid plaques is pivotal in understanding the pathophysiology of ischemic stroke secondary to large-artery atherosclerosis. In macroscopic evaluation, vulnerable plaques are characterized by one or more of the following features: microcalcification; neovascularization; lipid-rich necrotic cores (LRNCs); intraplaque hemorrhage (IPH); thin fibrous caps; plaque surface ulceration; huge dimensions, suggesting stenosis; and plaque rupture. Recognizing these macroscopic characteristics is crucial for estimating the risk of cerebr...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Giuseppe Miceli Maria Grazia Basso Chiara Pintus Andrea Roberta Pennacchio Elena Cocciola Mariagiovanna Cuffaro Martina Profita Giuliana Rizzo Antonino Tuttolomondo Source Type: research
Nomogram to Predict 90-Day All-Cause Mortality in Acute Ischemic Stroke Patients after Endovascular Thrombectomy
CONCLUSION: Our nomogram has incorporated relevant clinical and imaging features, including neurological deterioration, age, baseline NIHSS score, occlusive vessel location, malignant brain edema, and NLR ratio, to provide an accurate and reliable prediction of 90-day all-cause mortality in AIS patients undergoing EVT.PMID:38676479 | DOI:10.2174/0115672026311086240415050048 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 27, 2024 Category: Neurology Authors: Shiya Zhang Shuai Yu Xiaocui Wang Zhiliang Guo Jie Hou Huaishun Wang Zhichao Huang Guodong Xiao Shoujiang You Source Type: research
Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
This study provides supporting evidence that environmental lighting exacerbates ischemic injury and post-stroke mortality by a biological mechanism, that exposure to dLAN causes a fundamental shift of activated microglial phenotypes from beneficial to detrimental at an early time point after stroke, resulting in irreversible neuronal death.PMID:38677449 | DOI:10.1016/j.expneurol.2024.114796 (Source: Experimental Neurology)
Source: Experimental Neurology - April 27, 2024 Category: Neurology Authors: Jennifer A Liu William H Walker O Hecmarie Mel éndez-Fernández Jacob R Bumgarner Ning Zhang James C Walton Gordon P Meares A Courtney DeVries Randy J Nelson Source Type: research
Dystextia and dystypia due to phonological errors after ischemic stroke: a case report in a Japanese patient
Neurocase. 2024 Apr 26:1-8. doi: 10.1080/13554794.2024.2345403. Online ahead of print.ABSTRACTA 69-year-old Japanese male presented with acute dystextia and dystypia, defined as texting and typing impairments, respectively. His text input speed decreased due to a phonologically incorrect kana flick input on his smartphone. Additionally, dystypia occurred due to phonemic paragraphia of Romaji. Brain MRI revealed a new left lenticulostriate infarction sparing the cerebral cortex. SPECT showed reduced cerebral blood flow in the left inferior precentral frontal gyrus as well as in the infarction area. It was concluded that his...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Hiroshi Adachi Jun Numata Katsuya Nishida Hiroshi Yamasaki Naonobu Futamura Source Type: research
