Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs
CONCLUSIONS AND RELEVANCE: Assigning a designated clinician to execute a stepwise, routine care process following the checklist provided is a recommended intervention to overcome barriers. The intended impact is behavior change that reduces inappropriate prescribing.PMID:33855858 | DOI:10.1177/10600280211009567 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 15, 2021 Category: Drugs & Pharmacology Authors: Sandra L Kane-Gill Erin F Barreto Azra Bihorac John A Kellum Source Type: research

Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs
CONCLUSIONS AND RELEVANCE: Assigning a designated clinician to execute a stepwise, routine care process following the checklist provided is a recommended intervention to overcome barriers. The intended impact is behavior change that reduces inappropriate prescribing.PMID:33855858 | DOI:10.1177/10600280211009567 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 15, 2021 Category: Drugs & Pharmacology Authors: Sandra L Kane-Gill Erin F Barreto Azra Bihorac John A Kellum Source Type: research

Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs
CONCLUSIONS AND RELEVANCE: Assigning a designated clinician to execute a stepwise, routine care process following the checklist provided is a recommended intervention to overcome barriers. The intended impact is behavior change that reduces inappropriate prescribing.PMID:33855858 | DOI:10.1177/10600280211009567 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 15, 2021 Category: Drugs & Pharmacology Authors: Sandra L Kane-Gill Erin F Barreto Azra Bihorac John A Kellum Source Type: research

Factor VIII Inhibitor Bypassing Activity (FEIBA) Reversal for Apixaban and Rivaroxaban in Patients With Acute Intracranial and Nonintracranial Hemorrhage
CONCLUSION AND RELEVANCE: The combined ICH and non-ICH overall rates of effective hemostasis, TEE, and mortality were comparable to preexisting studies of FEIBA for factor Xa inhibitor reversal. The limitations inherent to the study design warrant a randomized controlled trial with an active comparator to confirm these observations.PMID:33843267 | DOI:10.1177/10600280211004583 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 12, 2021 Category: Drugs & Pharmacology Authors: Aleah R Hunt Shawn N Coffeen Dane L Shiltz Calvin Ice Jessi Parker Source Type: research

Factor VIII Inhibitor Bypassing Activity (FEIBA) Reversal for Apixaban and Rivaroxaban in Patients With Acute Intracranial and Nonintracranial Hemorrhage
CONCLUSION AND RELEVANCE: The combined ICH and non-ICH overall rates of effective hemostasis, TEE, and mortality were comparable to preexisting studies of FEIBA for factor Xa inhibitor reversal. The limitations inherent to the study design warrant a randomized controlled trial with an active comparator to confirm these observations.PMID:33843267 | DOI:10.1177/10600280211004583 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 12, 2021 Category: Drugs & Pharmacology Authors: Aleah R Hunt Shawn N Coffeen Dane L Shiltz Calvin Ice Jessi Parker Source Type: research

Factor VIII Inhibitor Bypassing Activity (FEIBA) Reversal for Apixaban and Rivaroxaban in Patients With Acute Intracranial and Nonintracranial Hemorrhage
CONCLUSION AND RELEVANCE: The combined ICH and non-ICH overall rates of effective hemostasis, TEE, and mortality were comparable to preexisting studies of FEIBA for factor Xa inhibitor reversal. The limitations inherent to the study design warrant a randomized controlled trial with an active comparator to confirm these observations.PMID:33843267 | DOI:10.1177/10600280211004583 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 12, 2021 Category: Drugs & Pharmacology Authors: Aleah R Hunt Shawn N Coffeen Dane L Shiltz Calvin Ice Jessi Parker Source Type: research

Usefulness of the Biomarker TIMP-2 •IGFBP7 for Acute Kidney Injury Assessment in Critically Ill Patients: A Narrative Review
CONCLUSIONS: Although there is evidence to suggest that the urinary TIMP-2•IGFBP7 biomarker is helpful in predicting AKI progression in general medical-surgical ICU patients when used within 12 hours of patient assessment in combination with routine testing, including serum creatinine and urine output, there is little evidence that its use leads to improvements in clinically important patient outcomes.PMID:33829897 | DOI:10.1177/10600280211005425 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 8, 2021 Category: Drugs & Pharmacology Authors: Brian L Erstad Source Type: research

Usefulness of the Biomarker TIMP-2 •IGFBP7 for Acute Kidney Injury Assessment in Critically Ill Patients: A Narrative Review
CONCLUSIONS: Although there is evidence to suggest that the urinary TIMP-2•IGFBP7 biomarker is helpful in predicting AKI progression in general medical-surgical ICU patients when used within 12 hours of patient assessment in combination with routine testing, including serum creatinine and urine output, there is little evidence that its use leads to improvements in clinically important patient outcomes.PMID:33829897 | DOI:10.1177/10600280211005425 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 8, 2021 Category: Drugs & Pharmacology Authors: Brian L Erstad Source Type: research

Usefulness of the Biomarker TIMP-2 •IGFBP7 for Acute Kidney Injury Assessment in Critically Ill Patients: A Narrative Review
CONCLUSIONS: Although there is evidence to suggest that the urinary TIMP-2•IGFBP7 biomarker is helpful in predicting AKI progression in general medical-surgical ICU patients when used within 12 hours of patient assessment in combination with routine testing, including serum creatinine and urine output, there is little evidence that its use leads to improvements in clinically important patient outcomes.PMID:33829897 | DOI:10.1177/10600280211005425 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 8, 2021 Category: Drugs & Pharmacology Authors: Brian L Erstad Source Type: research

Usefulness of the Biomarker TIMP-2 •IGFBP7 for Acute Kidney Injury Assessment in Critically Ill Patients: A Narrative Review
CONCLUSIONS: Although there is evidence to suggest that the urinary TIMP-2•IGFBP7 biomarker is helpful in predicting AKI progression in general medical-surgical ICU patients when used within 12 hours of patient assessment in combination with routine testing, including serum creatinine and urine output, there is little evidence that its use leads to improvements in clinically important patient outcomes.PMID:33829897 | DOI:10.1177/10600280211005425 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 8, 2021 Category: Drugs & Pharmacology Authors: Brian L Erstad Source Type: research

Complications and Management of Eptifibatide-Induced Thrombocytopenia
CONCLUSION AND RELEVANCE: Most cases of EIT were managed by withholding eptifibatide with platelet transfusion if necessary. The majority of complications included bleeding. However, significant procedure delays, prolonged hospital stay, thrombosis, and allergic reactions were also reported.PMID:33813877 | DOI:10.1177/10600280211006645 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Faisal Masood Saad Hashmi Adib Chaus Anna Hertsberg Eli D Ehrenpreis Source Type: research

Effect of Vasopressin Dose on Hemodynamic Response in Obese Patients With Septic Shock: A Retrospective Observational Study
CONCLUSION AND RELEVANCE: This represents the first analysis comparing standard and higher doses of vasopressin in obese patients with septic shock. Receipt of high-dose vasopressin was not associated with a difference in catecholamine requirement or improved outcomes. Further studies are warranted to provide guidance on the use of high-dose vasopressin in septic shock.PMID:33813908 | DOI:10.1177/10600280211007213 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Casey A Dubrawka Kevin D Betthauser Hannah E Pope Gabrielle A Gibson Source Type: research

Safety and Efficacy of Non-Vitamin K Oral Anticoagulant Use Early After Cardiac Surgery: A Systematic Review
CONCLUSIONS: There is limited evidence to guide NOAC use early after cardiac surgery. Three ongoing randomized trials will add to the literature and provide guidance for clinicians on whether, in whom, when, and how to use NOACs safely early after cardiac surgery.PMID:33813916 | DOI:10.1177/10600280211006830 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Erica H Z Wang Jian Ye Ricky Turgeon Source Type: research

Complications and Management of Eptifibatide-Induced Thrombocytopenia
CONCLUSION AND RELEVANCE: Most cases of EIT were managed by withholding eptifibatide with platelet transfusion if necessary. The majority of complications included bleeding. However, significant procedure delays, prolonged hospital stay, thrombosis, and allergic reactions were also reported.PMID:33813877 | DOI:10.1177/10600280211006645 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Faisal Masood Saad Hashmi Adib Chaus Anna Hertsberg Eli D Ehrenpreis Source Type: research

Effect of Vasopressin Dose on Hemodynamic Response in Obese Patients With Septic Shock: A Retrospective Observational Study
CONCLUSION AND RELEVANCE: This represents the first analysis comparing standard and higher doses of vasopressin in obese patients with septic shock. Receipt of high-dose vasopressin was not associated with a difference in catecholamine requirement or improved outcomes. Further studies are warranted to provide guidance on the use of high-dose vasopressin in septic shock.PMID:33813908 | DOI:10.1177/10600280211007213 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Casey A Dubrawka Kevin D Betthauser Hannah E Pope Gabrielle A Gibson Source Type: research

Safety and Efficacy of Non-Vitamin K Oral Anticoagulant Use Early After Cardiac Surgery: A Systematic Review
CONCLUSIONS: There is limited evidence to guide NOAC use early after cardiac surgery. Three ongoing randomized trials will add to the literature and provide guidance for clinicians on whether, in whom, when, and how to use NOACs safely early after cardiac surgery.PMID:33813916 | DOI:10.1177/10600280211006830 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Erica H Z Wang Jian Ye Ricky Turgeon Source Type: research

Complications and Management of Eptifibatide-Induced Thrombocytopenia
CONCLUSION AND RELEVANCE: Most cases of EIT were managed by withholding eptifibatide with platelet transfusion if necessary. The majority of complications included bleeding. However, significant procedure delays, prolonged hospital stay, thrombosis, and allergic reactions were also reported.PMID:33813877 | DOI:10.1177/10600280211006645 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Faisal Masood Saad Hashmi Adib Chaus Anna Hertsberg Eli D Ehrenpreis Source Type: research

Effect of Vasopressin Dose on Hemodynamic Response in Obese Patients With Septic Shock: A Retrospective Observational Study
CONCLUSION AND RELEVANCE: This represents the first analysis comparing standard and higher doses of vasopressin in obese patients with septic shock. Receipt of high-dose vasopressin was not associated with a difference in catecholamine requirement or improved outcomes. Further studies are warranted to provide guidance on the use of high-dose vasopressin in septic shock.PMID:33813908 | DOI:10.1177/10600280211007213 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Casey A Dubrawka Kevin D Betthauser Hannah E Pope Gabrielle A Gibson Source Type: research

Safety and Efficacy of Non-Vitamin K Oral Anticoagulant Use Early After Cardiac Surgery: A Systematic Review
CONCLUSIONS: There is limited evidence to guide NOAC use early after cardiac surgery. Three ongoing randomized trials will add to the literature and provide guidance for clinicians on whether, in whom, when, and how to use NOACs safely early after cardiac surgery.PMID:33813916 | DOI:10.1177/10600280211006830 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - April 5, 2021 Category: Drugs & Pharmacology Authors: Erica H Z Wang Jian Ye Ricky Turgeon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Pharmacogenomics in Pain Management: A Review of Relevant Gene-Drug Associations and Clinical Considerations
CONCLUSIONS: A one-size-fits-all approach to pain management is inadequate and outdated. With increasing genomic data and pharmacogenomic understanding, patient-specific genomic testing offers a comprehensive and personalized treatment alternative worthy of additional research and consideration.PMID:33771051 | DOI:10.1177/10600280211003875 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 27, 2021 Category: Drugs & Pharmacology Authors: Emily Brandl Zachery Halford Matthew D Clark Chris Herndon Source Type: research

Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit
Ann Pharmacother. 2021 Mar 20:10600280211003170. doi: 10.1177/10600280211003170. Online ahead of print.ABSTRACTBACKGROUND: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children.OBJECTIVE: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg hydromorphone). Secondary objectives included identification of the median time and hydromorphone rate at stabilization (defined as the first 24-hour period no hydromorphone rates changed, 80% of State Behavioral Scale [S...
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Maura Harkin Jamie L Miller Sin Yin Lim Stephen B Neely Christina K Walsh Peter N Johnson Source Type: research

Influence of RFC1 c.80A & gt;G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis
CONCLUSION AND RELEVANCE: RFC1 c.80 A>G is an important pharmacogenetic determinant of MTX therapy in RA. The RFC1 80A-allele robustly increased therapeutic efficacy and safety when folate was used along with MTX. Findings are relevant to decision-making in the clinical use of MTX as a treatment for RA patients harboring the RFC1 gene variant.PMID:33749319 | DOI:10.1177/10600280211002053 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Shaik Mohammad Naushad Salman A Alrokayan Fahad N Almajhdi Tajamul Hussain Source Type: research

Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit
Ann Pharmacother. 2021 Mar 20:10600280211003170. doi: 10.1177/10600280211003170. Online ahead of print.ABSTRACTBACKGROUND: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children.OBJECTIVE: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg hydromorphone). Secondary objectives included identification of the median time and hydromorphone rate at stabilization (defined as the first 24-hour period no hydromorphone rates changed, 80% of State Behavioral Scale [S...
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Maura Harkin Jamie L Miller Sin Yin Lim Stephen B Neely Christina K Walsh Peter N Johnson Source Type: research

Influence of RFC1 c.80A & gt;G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis
CONCLUSION AND RELEVANCE: RFC1 c.80 A>G is an important pharmacogenetic determinant of MTX therapy in RA. The RFC1 80A-allele robustly increased therapeutic efficacy and safety when folate was used along with MTX. Findings are relevant to decision-making in the clinical use of MTX as a treatment for RA patients harboring the RFC1 gene variant.PMID:33749319 | DOI:10.1177/10600280211002053 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Shaik Mohammad Naushad Salman A Alrokayan Fahad N Almajhdi Tajamul Hussain Source Type: research

Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit
Ann Pharmacother. 2021 Mar 20:10600280211003170. doi: 10.1177/10600280211003170. Online ahead of print.ABSTRACTBACKGROUND: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children.OBJECTIVE: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg hydromorphone). Secondary objectives included identification of the median time and hydromorphone rate at stabilization (defined as the first 24-hour period no hydromorphone rates changed, 80% of State Behavioral Scale [S...
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Maura Harkin Jamie L Miller Sin Yin Lim Stephen B Neely Christina K Walsh Peter N Johnson Source Type: research

Influence of RFC1 c.80A & gt;G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis
CONCLUSION AND RELEVANCE: RFC1 c.80 A>G is an important pharmacogenetic determinant of MTX therapy in RA. The RFC1 80A-allele robustly increased therapeutic efficacy and safety when folate was used along with MTX. Findings are relevant to decision-making in the clinical use of MTX as a treatment for RA patients harboring the RFC1 gene variant.PMID:33749319 | DOI:10.1177/10600280211002053 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Shaik Mohammad Naushad Salman A Alrokayan Fahad N Almajhdi Tajamul Hussain Source Type: research

Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit
Ann Pharmacother. 2021 Mar 20:10600280211003170. doi: 10.1177/10600280211003170. Online ahead of print.ABSTRACTBACKGROUND: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children.OBJECTIVE: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg hydromorphone). Secondary objectives included identification of the median time and hydromorphone rate at stabilization (defined as the first 24-hour period no hydromorphone rates changed, 80% of State Behavioral Scale [S...
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Maura Harkin Jamie L Miller Sin Yin Lim Stephen B Neely Christina K Walsh Peter N Johnson Source Type: research

Influence of RFC1 c.80A & gt;G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis
CONCLUSION AND RELEVANCE: RFC1 c.80 A>G is an important pharmacogenetic determinant of MTX therapy in RA. The RFC1 80A-allele robustly increased therapeutic efficacy and safety when folate was used along with MTX. Findings are relevant to decision-making in the clinical use of MTX as a treatment for RA patients harboring the RFC1 gene variant.PMID:33749319 | DOI:10.1177/10600280211002053 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Shaik Mohammad Naushad Salman A Alrokayan Fahad N Almajhdi Tajamul Hussain Source Type: research

Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit
Ann Pharmacother. 2021 Mar 20:10600280211003170. doi: 10.1177/10600280211003170. Online ahead of print.ABSTRACTBACKGROUND: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children.OBJECTIVE: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg hydromorphone). Secondary objectives included identification of the median time and hydromorphone rate at stabilization (defined as the first 24-hour period no hydromorphone rates changed, 80% of State Behavioral Scale [S...
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Maura Harkin Jamie L Miller Sin Yin Lim Stephen B Neely Christina K Walsh Peter N Johnson Source Type: research

Influence of RFC1 c.80A & gt;G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis
CONCLUSION AND RELEVANCE: RFC1 c.80 A>G is an important pharmacogenetic determinant of MTX therapy in RA. The RFC1 80A-allele robustly increased therapeutic efficacy and safety when folate was used along with MTX. Findings are relevant to decision-making in the clinical use of MTX as a treatment for RA patients harboring the RFC1 gene variant.PMID:33749319 | DOI:10.1177/10600280211002053 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 22, 2021 Category: Drugs & Pharmacology Authors: Shaik Mohammad Naushad Salman A Alrokayan Fahad N Almajhdi Tajamul Hussain Source Type: research

Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon
CONCLUSION AND RELEVANCE: Therapy with melatonin, ramelteon, and no melatonin receptor agonist resulted in similar rates of delirium in a mixed ICU population. Despite significant differences in agitation, sedation, and medication utilization, there was no differences in the clinical outcomes evaluated.PMID:33715466 | DOI:10.1177/10600280211002054 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 15, 2021 Category: Drugs & Pharmacology Authors: Natasha Romero Kevin M Dube Kenneth E Lupi Jeremy R DeGrado Source Type: research

Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon
CONCLUSION AND RELEVANCE: Therapy with melatonin, ramelteon, and no melatonin receptor agonist resulted in similar rates of delirium in a mixed ICU population. Despite significant differences in agitation, sedation, and medication utilization, there was no differences in the clinical outcomes evaluated.PMID:33715466 | DOI:10.1177/10600280211002054 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 15, 2021 Category: Drugs & Pharmacology Authors: Natasha Romero Kevin M Dube Kenneth E Lupi Jeremy R DeGrado Source Type: research

Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon
CONCLUSION AND RELEVANCE: Therapy with melatonin, ramelteon, and no melatonin receptor agonist resulted in similar rates of delirium in a mixed ICU population. Despite significant differences in agitation, sedation, and medication utilization, there was no differences in the clinical outcomes evaluated.PMID:33715466 | DOI:10.1177/10600280211002054 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 15, 2021 Category: Drugs & Pharmacology Authors: Natasha Romero Kevin M Dube Kenneth E Lupi Jeremy R DeGrado Source Type: research

Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon
CONCLUSION AND RELEVANCE: Therapy with melatonin, ramelteon, and no melatonin receptor agonist resulted in similar rates of delirium in a mixed ICU population. Despite significant differences in agitation, sedation, and medication utilization, there was no differences in the clinical outcomes evaluated.PMID:33715466 | DOI:10.1177/10600280211002054 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 15, 2021 Category: Drugs & Pharmacology Authors: Natasha Romero Kevin M Dube Kenneth E Lupi Jeremy R DeGrado Source Type: research

Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon
CONCLUSION AND RELEVANCE: Therapy with melatonin, ramelteon, and no melatonin receptor agonist resulted in similar rates of delirium in a mixed ICU population. Despite significant differences in agitation, sedation, and medication utilization, there was no differences in the clinical outcomes evaluated.PMID:33715466 | DOI:10.1177/10600280211002054 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 15, 2021 Category: Drugs & Pharmacology Authors: Natasha Romero Kevin M Dube Kenneth E Lupi Jeremy R DeGrado Source Type: research

Resources Assessment for Penicillin Allergy Testing Performed by Pharmacists at the Patient's Bedside
CONCLUSIONS AND RELEVANCE: This study describes penicillin allergy testing and the number of median weekly hospital pharmacist FTEs required, which was approximately 0.15. These data may aid in the implementation of this safe intervention that promotes narrower-spectrum antibiotherapy.PMID:33703922 | DOI:10.1177/10600280211002412 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 11, 2021 Category: Drugs & Pharmacology Authors: Sophie Gaudreau Genevi ève Bourque Kevin C ôté Cl ément Nutu Marie-France Beauchesne Audrey-Anne Longpr é Bianca Beloin-Jubinville Lorraine Legeleux Martin Blaqui ère Philippe Martin M élanie Gilbert Source Type: research

Resources Assessment for Penicillin Allergy Testing Performed by Pharmacists at the Patient's Bedside
CONCLUSIONS AND RELEVANCE: This study describes penicillin allergy testing and the number of median weekly hospital pharmacist FTEs required, which was approximately 0.15. These data may aid in the implementation of this safe intervention that promotes narrower-spectrum antibiotherapy.PMID:33703922 | DOI:10.1177/10600280211002412 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 11, 2021 Category: Drugs & Pharmacology Authors: Sophie Gaudreau Genevi ève Bourque Kevin C ôté Cl ément Nutu Marie-France Beauchesne Audrey-Anne Longpr é Bianca Beloin-Jubinville Lorraine Legeleux Martin Blaqui ère Philippe Martin M élanie Gilbert Source Type: research

Resources Assessment for Penicillin Allergy Testing Performed by Pharmacists at the Patient's Bedside
CONCLUSIONS AND RELEVANCE: This study describes penicillin allergy testing and the number of median weekly hospital pharmacist FTEs required, which was approximately 0.15. These data may aid in the implementation of this safe intervention that promotes narrower-spectrum antibiotherapy.PMID:33703922 | DOI:10.1177/10600280211002412 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 11, 2021 Category: Drugs & Pharmacology Authors: Sophie Gaudreau Genevi ève Bourque Kevin C ôté Cl ément Nutu Marie-France Beauchesne Audrey-Anne Longpr é Bianca Beloin-Jubinville Lorraine Legeleux Martin Blaqui ère Philippe Martin M élanie Gilbert Source Type: research

Transthyretin Amyloid Cardiomyopathy-Current and Future Therapies
CONCLUSION: Diagnostic modalities along with biomarker and genetic testing could detect disease earlier and target therapy more accurately. Novel therapies demonstrate potential treatment benefits and can help shape the standard of care for these patients.PMID:33685242 | DOI:10.1177/10600280211000351 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 9, 2021 Category: Drugs & Pharmacology Authors: Jankhna D Yadav Harjot Othee Kelly A Chan Damen C Man Paul P Belliveau Jennifer Towle Source Type: research

Caveats in Kidney Function Assessment
Ann Pharmacother. 2021 Mar 9:10600280211000347. doi: 10.1177/10600280211000347. Online ahead of print.NO ABSTRACTPMID:33685246 | DOI:10.1177/10600280211000347 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 9, 2021 Category: Drugs & Pharmacology Authors: Brian L Erstad David E Nix Source Type: research

Successful Alectinib Treatment Administered by Mixing With a Soft Diet in a Patient With Non-Small-Cell Lung Cancer With Severe Dysphagia
Ann Pharmacother. 2021 Mar 9:10600280211000703. doi: 10.1177/10600280211000703. Online ahead of print.NO ABSTRACTPMID:33685249 | DOI:10.1177/10600280211000703 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 9, 2021 Category: Drugs & Pharmacology Authors: Silvia V ázquez-Gómez Jaime Gul ín-Dávila Araceli Iglesias-Santamar ía I Rodr íguez-Losada Natalia Fern ández-Núñez Source Type: research

Transthyretin Amyloid Cardiomyopathy-Current and Future Therapies
CONCLUSION: Diagnostic modalities along with biomarker and genetic testing could detect disease earlier and target therapy more accurately. Novel therapies demonstrate potential treatment benefits and can help shape the standard of care for these patients.PMID:33685242 | DOI:10.1177/10600280211000351 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 9, 2021 Category: Drugs & Pharmacology Authors: Jankhna D Yadav Harjot Othee Kelly A Chan Damen C Man Paul P Belliveau Jennifer Towle Source Type: research

Caveats in Kidney Function Assessment
Ann Pharmacother. 2021 Mar 9:10600280211000347. doi: 10.1177/10600280211000347. Online ahead of print.NO ABSTRACTPMID:33685246 | DOI:10.1177/10600280211000347 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 9, 2021 Category: Drugs & Pharmacology Authors: Brian L Erstad David E Nix Source Type: research

Successful Alectinib Treatment Administered by Mixing With a Soft Diet in a Patient With Non-Small-Cell Lung Cancer With Severe Dysphagia
Ann Pharmacother. 2021 Mar 9:10600280211000703. doi: 10.1177/10600280211000703. Online ahead of print.NO ABSTRACTPMID:33685249 | DOI:10.1177/10600280211000703 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 9, 2021 Category: Drugs & Pharmacology Authors: Silvia V ázquez-Gómez Jaime Gul ín-Dávila Araceli Iglesias-Santamar ía I Rodr íguez-Losada Natalia Fern ández-Núñez Source Type: research