Warfarin-Induced Rapid Rise in INR Post-Cardiac Surgery Is Not Associated With Increased Bleeding Risk.
Conclusion and Relevance: This represents the first report to assess warfarin-related rapid-rise INR in post-cardiac surgery patients and found correlation to hospital LOS but not bleed events. Conservative warfarin dosing may be warranted until further research can be conducted. PMID: 31304766 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 14, 2019 Category: Drugs & Pharmacology Authors: Olson LM, Nei AM, Dierkhising RA, Joyce DL, Nei SD Tags: Ann Pharmacother Source Type: research

The Effect of Patient-Specific Drug-Drug Interaction Alerting on the Frequency of Alerts: A Pilot Study.
Conclusion and Relevance: Patient-specific DDI alerting is an innovative and effective approach to reduce the number of DDI alerts, may potentially increase the appropriateness of alerts, and may decrease the potential for alert fatigue. PMID: 31296026 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 11, 2019 Category: Drugs & Pharmacology Authors: Horn J, Ueng S Tags: Ann Pharmacother Source Type: research

Sufentanil Sublingual Tablet: A New Option for Acute Pain Management.
Conclusions: SST can satisfy an unmet need in patients with acute pain, who require parenteral opioids, and either have no IV access or require prolonged time to achieve IV access such as patients in outpatient surgical centers, EDs, and the battlefield. During periods of parenteral opioid shortage, SST may provide another option for adequate analgesia. PMID: 31280585 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 7, 2019 Category: Drugs & Pharmacology Authors: Reardon CE, Kane-Gill SL, Smithburger PL, Dasta JF Tags: Ann Pharmacother Source Type: research

Doxycycline and Tooth Discoloration in Children: Changing of Recommendations Based on Evidence of Safety.
Abstract Doxycycline use has historically been limited to children older than 8 years because of concerns regarding permanent tooth discoloration. Six studies assessed tooth discoloration in at least 338 patients exposed to doxycycline before 8 years of age. Six patients had potential discoloration, but studies consistently found no difference in tooth discoloration between exposed patients and controls. Recommendations have changed stating doxycycline, but not other tetracyclines, can be used for short courses (
Source: The Annals of Pharmacotherapy - July 7, 2019 Category: Drugs & Pharmacology Authors: Stultz JS, Eiland LS Tags: Ann Pharmacother Source Type: research

Management of Idiopathic Pulmonary Fibrosis.
Conclusions: IPF is a progressive disease, but treatments are available that can slow the progression of the disease. Clinical pharmacists can play an important role in the care of patients with IPF through patient education, monitoring medication compliance and safety, ensuring drugs for comorbidities are optimized, and preventive strategies such as immunizations. PMID: 31280590 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 7, 2019 Category: Drugs & Pharmacology Authors: Pleasants R, Tighe RM Tags: Ann Pharmacother Source Type: research

Comment: Managing Diabetes and Preventing Heart Disease: Have We Found a Safe and Effective Agent?
PMID: 31280591 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 7, 2019 Category: Drugs & Pharmacology Authors: Reeder JA, Gilbert BW, Moran DA Tags: Ann Pharmacother Source Type: research

Reply: Managing Diabetes and Preventing Heart Disease: Have We Found a Safe and Effective Agent?
PMID: 31271040 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 4, 2019 Category: Drugs & Pharmacology Authors: Cheng JWM, Colucci V, Kalus JS, Spinler SA Tags: Ann Pharmacother Source Type: research

β-Blockers and the Rate of Chronic Obstructive Pulmonary Disease Exacerbations.
Conclusions: Based on the limited number of studies that address β-blocker use in COPD, it appears that exacerbations are not increased and may be decreased. A randomized, placebo-controlled trial is in progress to possibly provide more definitive answers to this question. Until the trial is complete, β-blockers should not be withheld in COPD patients who have concurrent cardiovascular conditions, especially where there is a mortality benefit. PMID: 31271049 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - July 4, 2019 Category: Drugs & Pharmacology Authors: Mersfelder TL, Shiltz DL Tags: Ann Pharmacother Source Type: research

Assessment of Opioid Cross-reactivity and Provider Perceptions in Hospitalized Patients With Reported Opioid Allergies.
Conclusions: The risk of IMRs caused by opioids is low in patients with H-IMRs to opioids. Opioid allergy documentations may propagate alert fatigue and unwarranted prescribing changes. PMID: 31253049 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 28, 2019 Category: Drugs & Pharmacology Authors: Powell MZ, Mueller SW, Reynolds PM Tags: Ann Pharmacother Source Type: research

Expanding Beyond Vancomycin and Aminoglycosides: A Novel Foscarnet Pharmacist-Managed Dosing Service.
PMID: 31242757 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 26, 2019 Category: Drugs & Pharmacology Authors: Pillinger KE, McClanahan S, Arnall J, Taylor MC Tags: Ann Pharmacother Source Type: research

Sodium-Glucose Cotransporters as Potential Therapeutic Targets in Patients With Type 1 Diabetes Mellitus: An Update on Phase 3 Clinical Trial Data.
Conclusions: Phase 3 trial data of SGLT inhibitors provide evidence for sustained efficacy in T1DM patients. Appropriate patient selection for therapy and routine monitoring are essential to minimize associated risks. PMID: 31226886 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 21, 2019 Category: Drugs & Pharmacology Authors: Patel K, Carbone A Tags: Ann Pharmacother Source Type: research

The Effect of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors in Patients Prescribed Regular U-500 Insulin.
Conclusion and Relevance: This is the first study to examine SGLT-2 inhibitors in combination with U-500 insulin therapy. Clinically, the addition of a GLP-1 agonist and/or SGLT-2 inhibitor can improve A1C and decrease TDD, BMI, and body weight. PMID: 31215219 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 19, 2019 Category: Drugs & Pharmacology Authors: Meade LT, Mannka ML Tags: Ann Pharmacother Source Type: research

Association Between Drug Exposure and Occurrence of Parkinsonism in Korea: A Population-Based Case-Control Study.
Conclusion and Relevance: At the population level, use of propulsives, antipsychotics, and flunarizine had a significant association with the increased risk of parkinsonism, depending on recency and cumulative dose. Drugs associated with parkinsonism should be used with careful monitoring to prevent drug-induced parkinsonism. PMID: 31216861 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 19, 2019 Category: Drugs & Pharmacology Authors: Kim S, Cheon SM, Suh HS Tags: Ann Pharmacother Source Type: research

What Is the Evidence for Co-trimoxazole, Clindamycin, Doxycycline, and Minocycline in the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Pneumonia?
CONCLUSIONS: There are limited data to support use of TMP-SMX, clindamycin, doxycycline, or minocycline in MRSA pneumonia treatment. Randomized controlled trials are required to determine the effectiveness of these antibiotics. Clinicians should base their decision to use these agents on a case-by-case basis depending on clinical status and susceptibility results. PMID: 31177803 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 10, 2019 Category: Drugs & Pharmacology Authors: Hong J, Ensom MHH, Lau TTY Tags: Ann Pharmacother Source Type: research

Stiripentol: A Novel Antiseizure Medication for the Management of Dravet Syndrome.
CONCLUSIONS: Stiripentol is an effective adjunctive therapy for reducing the frequency and duration of refractory seizures in patients with Dravet syndrome. Its role in the treatment of other refractory epilepsies requires further study. PMID: 31167540 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 6, 2019 Category: Drugs & Pharmacology Authors: Buck ML, Goodkin HP Tags: Ann Pharmacother Source Type: research

Dalbavancin Use in the Emergency Department Setting.
Abstract BACKGROUND: Although dalbavancin's (DBV's) long half-life and one-time dosing strategy confer ideal administration in the ambulatory setting, the optimal role of DBV in the management of acute bacterial skin and skin structure infections (ABSSSIs) remains to be elucidated. OBJECTIVES: The primary objective of this study was to compare treatment outcomes of ABSSSI between patients who received DBV in the emergency department (ED) as part of standard care versus patients who received DBV as part of a telehealth program. METHODS: This was a retrospective cohort study evaluating patients who receive...
Source: The Annals of Pharmacotherapy - June 3, 2019 Category: Drugs & Pharmacology Authors: Patel M, Smalley S, Dubrovskaya Y, Siegfried J, Caspers C, Pham V, Press RA, Papadopoulos J Tags: Ann Pharmacother Source Type: research

Comment: Andexanet alfa: A Novel Factor Xa Inhibitor Reversal Agent.
PMID: 31142121 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 29, 2019 Category: Drugs & Pharmacology Authors: Gilbert BW, Reeder JA Tags: Ann Pharmacother Source Type: research

Author Reply to Letter to the Editor: "Association Between Lung Cancer and Calcium Channel Blockers Use".
Author Reply to Letter to the Editor: "Association Between Lung Cancer and Calcium Channel Blockers Use". Ann Pharmacother. 2019 May 29;:1060028019853285 Authors: Rotshild V, Perlman A, Matok I PMID: 31137953 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 29, 2019 Category: Drugs & Pharmacology Authors: Rotshild V, Perlman A, Matok I Tags: Ann Pharmacother Source Type: research

Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control.
Conclusion and Relevance: Over the course of this 6-month retrospective study, patients using medical cannabis for intractable pain experienced a significant reduction in the number of MMEs available to use for pain control. No significant difference was noted in DE from baseline. Further prospective studies are warranted to confirm or deny the opioid-sparing effects of medical cannabis when used to treat intractable pain. PMID: 31129977 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 25, 2019 Category: Drugs & Pharmacology Authors: O'Connell M, Sandgren M, Frantzen L, Bower E, Erickson B Tags: Ann Pharmacother Source Type: research

Associations Between Potentially Inappropriate Medications and Adverse Health Outcomes in the Elderly: A Systematic Review and Meta-analysis.
Conclusion and Relevance: We recommend that clinicians avoid prescribing PIMs for older adults whenever feasible. In addition, the observed associations should be generalized to other countries with different PIM criteria with caution. PMID: 31129978 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 25, 2019 Category: Drugs & Pharmacology Authors: Xing XX, Zhu C, Liang HY, Wang K, Chu YQ, Zhao LB, Jiang C, Wang YQ, Yan SY Tags: Ann Pharmacother Source Type: research

Association Between Lung Cancer and Calcium Channel Blockers Use.
PMID: 31122036 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 23, 2019 Category: Drugs & Pharmacology Authors: Lai SW Tags: Ann Pharmacother Source Type: research

Pancreatic Hyperamylasemia and Hyperlipasemia Associated With Carfilzomib in Multiple Myeloma.
PMID: 31104468 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 20, 2019 Category: Drugs & Pharmacology Authors: Nakamura Y, Okuda I, Uchida Y, Ito Y, Wakimoto N Tags: Ann Pharmacother Source Type: research

Efficacy of Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review.
CONCLUSION: Current data for capsaicin efficacy in CHS is of low methodological quality. However, the limited data on alternative antiemetic therapies and capsaicin's favorable risk-benefit profile make it a reasonable adjunctive treatment option. PMID: 31104487 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 18, 2019 Category: Drugs & Pharmacology Authors: McConachie SM, Caputo RA, Wilhelm SM, Kale-Pradhan PB Tags: Ann Pharmacother Source Type: research

Unrecognized Drug Interaction: Ranolazine Adverse Effects Intensified by Darunavir-Cobicistat.
PMID: 31106569 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 18, 2019 Category: Drugs & Pharmacology Authors: Dougherty JA, Wynn RE, Maarsingh H Tags: Ann Pharmacother Source Type: research

Eravacycline: The Tetracyclines Strike Back.
CONCLUSIONS: Eravacycline is a new tetracycline antibiotic with a broad spectrum of activity that has demonstrated efficacy in the treatment of cIAIs. Although it has activity against multidrug-resistant organisms, data are limited for other indications. PMID: 31081341 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 12, 2019 Category: Drugs & Pharmacology Authors: Heaney M, Mahoney MV, Gallagher JC Tags: Ann Pharmacother Source Type: research

Responding to Manuscript Reviewer and Editor Comments.
PMID: 31064199 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 7, 2019 Category: Drugs & Pharmacology Authors: Nahata MC, Sorkin EM Tags: Ann Pharmacother Source Type: research

A Pseudo-False Negative Urine Methadone Screen in a Patient Treated With Rifampin.
PMID: 31055939 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 5, 2019 Category: Drugs & Pharmacology Authors: Anderson CE, Williams J, Packer CD Tags: Ann Pharmacother Source Type: research

Discontinuation of Direct Oral Anticoagulants in Response to Attorney Advertisements: Data From the FDA Adverse Event Reporting System.
PMID: 31055957 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 5, 2019 Category: Drugs & Pharmacology Authors: Mohamoud M, Patanavanich S, Crew P, McCulley L, Munoz M, Kortepeter C, Jones SC, Woronow D, Dal Pan G Tags: Ann Pharmacother Source Type: research

Intravenous Acetaminophen-Induced Hypotension: A Review of the Current Literature.
CONCLUSIONS: Available evidence indicates that the administration of IV acetaminophen may be harmful in the critically ill. Additional monitoring is likely required when using IV acetaminophen in this specific population, particularly if a patient is hemodynamically unstable prior to administration. PMID: 31046402 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 3, 2019 Category: Drugs & Pharmacology Authors: Maxwell EN, Johnson B, Cammilleri J, Ferreira JA Tags: Ann Pharmacother Source Type: research

Omadacycline: A New Tetracycline Antibiotic.
CONCLUSION: Omadacycline is an alternative treatment option for ABSSSI and CABP. PMID: 30917674 [PubMed - in process] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 29, 2019 Category: Drugs & Pharmacology Authors: Dougherty JA, Sucher AJ, Chahine EB, Shihadeh KC Tags: Ann Pharmacother Source Type: research

Evaluation of Lactation Compatibility Reference Recommendations.
Conclusion and Relevance: Variation continues to exist across resources with regard to recommendations for medication safety in lactation. LactMed represents the most up-to-date and comprehensive review of literature in this review. When making decisions regarding medication use during lactation, health care professionals should consider reviewing data behind the recommendations and consulting multiple resources. PMID: 30907111 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 24, 2019 Category: Drugs & Pharmacology Authors: Holmes AP, Harris JB, Ware S Tags: Ann Pharmacother Source Type: research

Baricitinib: The Second FDA-Approved JAK Inhibitor for the Treatment of Rheumatoid Arthritis.
CONCLUSION: Baricitinib is the second medication in its class and has been proven efficacious for the treatment of RA. Given concerns for adverse effects associated with baricitinib, it should be reserved for patients who have failed one or more TNFis. PMID: 30907116 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 24, 2019 Category: Drugs & Pharmacology Authors: Mogul A, Corsi K, McAuliffe L Tags: Ann Pharmacother Source Type: research

Payers' Perspectives on Pharmacist-Directed Care in a Community Pharmacy Setting.
CONCLUSIONS AND RELEVANCE: A quantitative assessment of payer attitudes for pharmacist-provided, community-delivered advanced clinical practice was positive. Payers were positive about pharmacist contributions to the provision of heath and medication information. Continued development and deployment of advanced clinical services at the community pharmacy appears to be a financially viable model. PMID: 30895798 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 21, 2019 Category: Drugs & Pharmacology Authors: Merrill BS, Tak CR, Feehan M, Munger MA Tags: Ann Pharmacother Source Type: research

Marijuana Use in Older Adults: Employing a Risk Reduction Strategy.
PMID: 30894014 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 20, 2019 Category: Drugs & Pharmacology Authors: Marcum ZA, Tu S, Crawford C, Hirano L Tags: Ann Pharmacother Source Type: research

Impact of a Direct Oral Anticoagulant Population Management Tool on Anticoagulation Therapy Monitoring in Clinical Practice.
Abstract BACKGROUND: The optimal monitoring and follow-up strategy for long-term direct oral anticoagulant (DOAC) therapy has not been established. Historically, at our medical center, DOAC patients were referred to a clinical pharmacy specialist managed anticoagulation clinic (AC) for monitoring via regularly scheduled encounters (face-to-face or telephone). OBJECTIVE: To determine if implementation of a DOAC Population Management Tool (PMT) designed to identify patients who most likely require clinical review and possibly intervention, would improve the efficacy (interventions per patient) and efficiency (t...
Source: The Annals of Pharmacotherapy - March 10, 2019 Category: Drugs & Pharmacology Authors: Valencia D, Spoutz P, Stoppi J, Kibert JL, Allen A, Parra D, Hough A Tags: Ann Pharmacother Source Type: research

No Loose Ends: A Review of the Pharmacotherapy of Hairy Cell and Hairy Cell Leukemia Variant.
CONCLUSION: HCL and HCLv are uncommon lymphoid neoplasms that lead to a characteristic constellation of symptoms. The emergence of PAs and novel targeted agents have improved the likelihood and durability of responses for these patients. PMID: 30841702 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 6, 2019 Category: Drugs & Pharmacology Authors: King AC, Kabel CC, Pappacena JJ, Stump SE, Daley RJ Tags: Ann Pharmacother Source Type: research

Assessment of Condition and Medication Knowledge Gaps Among Atrial Fibrillation Patients: A Systematic Review and Meta-analysis.
Conclusion and Relevance: This systematic review identified several AF patient knowledge gaps about their condition and its treatment that can inform the development of AF patient education programs. PMID: 30829052 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 2, 2019 Category: Drugs & Pharmacology Authors: Salmasi S, De Vera MA, Barry A, Bansback N, Harrison M, Lynd LD, Loewen PS Tags: Ann Pharmacother Source Type: research

Comparing Anti-Factor Xa and Activated Partial Thromboplastin Levels for Monitoring Unfractionated Heparin.
Conclusion and Relevance: Significantly higher IV heparin doses were required to achieve therapeutic anti-Xa levels after transitioning from an aPTT-based protocol in the largely unstudied veteran population. However, the transition from aPTT to anti-Xa monitoring appears safe and efficacious in these patients. PMID: 30813751 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Authors: Wahking RA, Hargreaves RH, Lockwood SM, Haskell SK, Davis KW Tags: Ann Pharmacother Source Type: research

Ceftaroline-Induced Thrombocytopenia: A Case Report.
PMID: 30813752 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Authors: Britt RS, Pearson JC, Mahoney MV, Carlson AA Tags: Ann Pharmacother Source Type: research

Andexanet alfa: A Novel Factor Xa Inhibitor Reversal Agent.
CONCLUSIONS: The new FDA approval of andexanet alfa will allow safer use of oral anticoagulants and will likely further the use of direct oral anticoagulants for anticoagulant needs. Reversing enoxaparin-/edoxaban-induced bleeding with this agent should be limited because there is no FDA approval owing to the fact that only phase II trial data available. PMID: 30813754 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Authors: Powell J, Taylor J, Garland SG Tags: Ann Pharmacother Source Type: research

Copanlisib: An Intravenous Phosphatidylinositol 3-Kinase (PI3K) Inhibitor for the Treatment of Relapsed Follicular Lymphoma.
CONCLUSIONS: Copanlisib provides an alternative option for patients with relapsed FL. It is safe and effective and has an acceptable toxicity profile. PMID: 30813760 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Authors: Eltantawy A, Vallejos X, Sebea E, Evans K Tags: Ann Pharmacother Source Type: research

Erenumab: A First-in-Class Monoclonal Antibody for Migraine Prevention.
CONCLUSION: Erenumab is an effective once-monthly injectable agent for migraine prevention in patients with chronic or episodic migraine. It is also effective for patients who have previously failed migraine preventive therapy. Erenumab has a favorable adverse effect profile, which may improve patient adherence. PMID: 30813769 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Authors: Garland SG, Smith SM, Gums JG Tags: Ann Pharmacother Source Type: research

Octreotide Added to a Proton Pump Inhibitor Versus a Proton Pump Inhibitor Alone in Nonvariceal Upper-Gastrointestinal Bleeds.
Conclusion and Relevance: Our study observed no difference in clinical end points. This suggests that octreotide provides no additional major clinical benefit in NVUGIB, and PPI therapy alone may be sufficient. PMID: 30803243 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 25, 2019 Category: Drugs & Pharmacology Authors: Riha HM, Wilkinson R, Twilla J, Harris LJ, Kimmons LA, Kocak M, Van Berkel MA Tags: Ann Pharmacother Source Type: research

Severe Peripheral Edema in a Dabigatran-Treated Patient.
PMID: 30803256 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 25, 2019 Category: Drugs & Pharmacology Authors: Famularo G Tags: Ann Pharmacother Source Type: research

Assessment of Late Thromboembolic Complications Post-Fontan Procedure in Relation to Different Antithrombotic Regimens: 30-Years' Follow-up Experience.
Conclusion and Relevance: The incidence rate of late clinical TECs post-Fontan procedure in our population is low. Warfarin was not superior to aspirin for prevention of late TECs. Yet warfarin was associated with a higher rate of bleeding. This finding suggests a simpler antithrombotic regimen for prevention of TEC after 1-year post-Fontan procedure. PMID: 30788973 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 21, 2019 Category: Drugs & Pharmacology Authors: Al-Jazairi AS, Al Alshaykh HA, Di Salvo G, De Vol EB, Alhalees ZY Tags: Ann Pharmacother Source Type: research

Managing Pharmacotherapy in People Living With HIV and Concomitant Malignancy.
CONCLUSIONS: The availability of ART has transformed AIDS into a chronic medical condition, and PLWH are experiencing age-related malignancies. Pharmacists play an important role in the management of this patient population. PMID: 30770025 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 15, 2019 Category: Drugs & Pharmacology Authors: Olin JL, Klibanov O, Chan A, Spooner LM Tags: Ann Pharmacother Source Type: research

Effect of an Asthma Question Prompt List and Video Intervention on Adolescents' Medication Adherence 12 Months Later.
Abstract BACKGROUND: Many adolescents do not obtain the maximum benefit from their asthma medications. Improving patient-provider communication may improve adolescents' asthma knowledge, adherence, and clinical outcomes. OBJECTIVE: To determine how a question prompt list and educational video intervention affect youth- and caregiver-reported medication adherence and self-reported medication problems. METHODS: Adolescents with persistent asthma (n = 359; 56.4% with moderate to severe asthma) and their caregivers were enrolled in a randomized controlled trial at 4 pediatric clinics. Intervention group fami...
Source: The Annals of Pharmacotherapy - February 13, 2019 Category: Drugs & Pharmacology Authors: Davis SA, Carpenter D, Lee C, Garcia N, Reuland DS, Tudor G, Loughlin CE, Sleath B Tags: Ann Pharmacother Source Type: research

Intravenous Olanzapine for the Management of Agitation: Review of the Literature.
CONCLUSIONS: The use of IV olanzapine remains controversial in the absence of clear evidence evaluating safety and efficacy. Future studies are warranted comparing IV olanzapine with more commonly utilized and Food and Drug Administration-approved treatment modalities for acute agitation in the emergency department and other settings. PMID: 30758221 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2019 Category: Drugs & Pharmacology Authors: Khorassani F, Saad M Tags: Ann Pharmacother Source Type: research

Dolutegravir-Rilpivirine, Dual Antiretroviral Therapy for the Treatment of HIV-1 Infection.
CONCLUSIONS: This dual therapy combination of DTG-RPV provides maintenance of virological suppression as a switch strategy with few drug interactions and positive effects on lipids and renal and bone health. PMID: 30758229 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2019 Category: Drugs & Pharmacology Authors: Hester EK, Astle K Tags: Ann Pharmacother Source Type: research

Toxic Tacrolimus Concentrations Associated With Intravenous Use of Metoclopramide in a Lung Transplant Patient.
PMID: 30739475 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 10, 2019 Category: Drugs & Pharmacology Authors: Provenzani A, D'alessandro N, Polidori P Tags: Ann Pharmacother Source Type: research