Cancer-Associated Venous Thromboembolism Treatment With Anti-Xa Versus Weight-Based Enoxaparin: A Retrospective Evaluation of Safety and Efficacy.
CONCLUSION AND RELEVANCE: Patients with cancer receiving anti-Xa-guided enoxaparin dose adjustments for initial VTE, compared with weight-based dosing, had no significant difference in the rate of recurrent VTE or major bleed. PMID: 33455432 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 16, 2021 Category: Drugs & Pharmacology Authors: Hart K, Andrick B, Grassi S, Manikowski J, Graham J Tags: Ann Pharmacother Source Type: research

Safety of Intravenous Olanzapine Administration at a Tertiary Academic Medical Center.
Abstract BACKGROUND: Although approved by the Food and Drug Administration for intramuscular administration only, analyses have described the administration of intravenous push (IVP) olanzapine, particularly for acute agitation. The safety and efficacy of IVP olanzapine has mostly been limited to emergency department patients. OBJECTIVE: To evaluate the safety of IVP olanzapine administration in the inpatient setting. METHODS: This single-center, retrospective analysis was conducted between July 1, 2018, and December 31, 2019, at Brigham and Women's Hospital in Boston, Massachusetts. Adult patients who r...
Source: The Annals of Pharmacotherapy - January 16, 2021 Category: Drugs & Pharmacology Authors: Hunt NF, McLaughlin KC, Kovacevic MP, Lupi KE, Dube KM Tags: Ann Pharmacother Source Type: research

A Systematic Review of Blinatumomab in the Treatment of Acute Lymphoblastic Leukemia: Engaging an Old Problem With New Solutions.
CONCLUSIONS: Blinatumomab provides a paradigm-shifting treatment option; however, many questions surrounding optimal patient selection, sequencing, and cost-effectiveness remain. PMID: 33435716 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 13, 2021 Category: Drugs & Pharmacology Authors: Halford Z, Coalter C, Gresham V, Brown T Tags: Ann Pharmacother Source Type: research

A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury.
CONCLUSIONS: The pharmacologic agent with the most supporting literature is amantadine used for cognitive improvement after TBI. Other neurostimulants with positive, despite more limited, evidence include methylphenidate, modafinil, levodopa, and citalopram. Caution is warranted with other neurostimulants given higher rates of adverse effects or lack of benefit observed in clinical trials. PMID: 33435717 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 12, 2021 Category: Drugs & Pharmacology Authors: Kakehi S, Tompkins DM Tags: Ann Pharmacother Source Type: research

Oliceridine for the Management of Acute Postoperative Pain.
CONCLUSION: Oliceridine has obvious analgesic effects in patients with moderate or severe pain after surgery; additionally, it has a favorable safety and tolerability profile. PMID: 33423508 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 11, 2021 Category: Drugs & Pharmacology Authors: Liu Y, Hu Q, Yang J Tags: Ann Pharmacother Source Type: research

Amisulpride: A New Drug for Management of Postoperative Nausea and Vomiting.
CONCLUSIONS: Amisulpride is an important new option for the multimodal management of PONV in adults, and it may be the preferred dopamine antagonist because of the more favorable safety profile that results from its unique pharmacological properties. PMID: 33412897 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 8, 2021 Category: Drugs & Pharmacology Authors: Haber SL, Graybill A, Minasian A Tags: Ann Pharmacother Source Type: research

Is Statin Use Associated With Risk of Thyroid Diseases? Results of a Retrospective Cohort Study.
CONCLUSION AND RELEVANCE: This study did not demonstrate any association of statins with harmful effects on thyroid diseases, which offers assurance to clinicians and patients. Furthermore, statin use appears to be associated with a decreased risk of thyroid cancer, but more studies are needed. PMID: 33412925 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 7, 2021 Category: Drugs & Pharmacology Authors: Trivedi LU, Femnou Mbuntum L, Halm EA, Mansi I Tags: Ann Pharmacother Source Type: research

Effect of Metformin on Circulating Levels of Inflammatory Markers in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
CONCLUSION: The present study evidences that therapy with metformin can reduces CRP level significantly in T2D patients compared to other inflammatory markers. PMID: 33412927 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 7, 2021 Category: Drugs & Pharmacology Authors: Karbalaee-Hasani A, Khadive T, Eskandari M, Shahidi S, Mosavi M, Nejadebrahimi Z, Khalkhali L, Sangdari A, Mohammadi D, Soltani A, Khodabandehloo H, Hosseini H, Koushki M Tags: Ann Pharmacother Source Type: research

The Role of Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure, Regardless of Diabetes Status: Focus on Cardiovascular Disease.
CONCLUSIONS: SGLT2 inhibitor therapy reduces CV death and hospitalizations in HFrEF patients regardless of T2DM. The decision to prescribe this class of drugs should not be determined by glycemic status. PMID: 33401940 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 5, 2021 Category: Drugs & Pharmacology Authors: Ferrari F, Martins VM, Scheffel RS, da Silveira AD, Motta MT, Moriguchi EH, Santos RD, Stein R Tags: Ann Pharmacother Source Type: research

AOP Alphabetical New Reviewers Oct 31, 2019 - Oct 18, 2020.
Authors: PMID: 33242990 [PubMed - in process] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 29, 2020 Category: Drugs & Pharmacology Tags: Ann Pharmacother Source Type: research

Ongentys (Opicapone): A New COMT Inhibitor for the Treatment of Parkinson's Disease.
CONCLUSION: Opicapone is a safe and effective COMT inhibitor shown to reduce off episodes in patients with PD. PMID: 33233916 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 24, 2020 Category: Drugs & Pharmacology Authors: St Onge E, Vanderhoof M, Miller S Tags: Ann Pharmacother Source Type: research

A Critical Evaluation of Newer β-Lactam Antibiotics for Treatment of Pseudomonas aeruginosa Infections.
CONCLUSIONS: Newer agents, including ceftazidime-avibactam, ceftolozane-tazobactam, imipenem-relebactam, and cefiderocol, are useful for the treatment of MDR P aeruginosa infections. These agents offer improved efficacy and less toxicity compared with aminoglycosides and polymyxins and can be used for pathogens that are resistant to first-line antipseudomonal β-lactams. Selection of one agent over another should consider availability, turnaround of susceptibility testing, and product cost. Efficacy data specific for pseudomonal infections are limited, and there are no direct comparisons between the newer agents. ...
Source: The Annals of Pharmacotherapy - November 23, 2020 Category: Drugs & Pharmacology Authors: Blomquist KC, Nix DE Tags: Ann Pharmacother Source Type: research

Safety of High-Dose Unfractionated Heparin for Prophylaxis of Venous Thromboembolism in Hospitalized Obese Patients.
CONCLUSION AND RELEVANCE: High-dose UFH was associated with an increased bleeding event rate compared with standard-dose UFH in patients with a BMI ≥30 kg/m2. This raises safety concerns about the appropriateness of utilizing this regimen in this population. PMID: 33215504 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 20, 2020 Category: Drugs & Pharmacology Authors: Regis T, Goriacko P, Ferguson N Tags: Ann Pharmacother Source Type: research

A Review of β-Lactam-Associated Neutropenia and Implications for Cross-reactivity.
CONCLUSION: Future use of β-lactams with differing R1 side chains, particularly those from a separate class, should not be deemed contraindicated following β-lactam-induced neutropenia and may be considered when indicated, with close laboratory monitoring. PMID: 33215507 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 20, 2020 Category: Drugs & Pharmacology Authors: Cimino C, Allos BM, Phillips EJ Tags: Ann Pharmacother Source Type: research

Comment: Walk the Line-The Importance of Well-informed Interpretation of QT Prolongation.
PMID: 33215511 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 20, 2020 Category: Drugs & Pharmacology Authors: Chua D, Brar T Tags: Ann Pharmacother Source Type: research

Reply: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment.
PMID: 33191775 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 15, 2020 Category: Drugs & Pharmacology Authors: Mullins C, Beaulac K, Sylvia L Tags: Ann Pharmacother Source Type: research

Direct Oral Anticoagulants Versus Warfarin in the Treatment of Left Ventricular Thrombus.
CONCLUSION AND RELEVANCE: Our data suggest that DOACs may be reasonable alternatives for treatment of LV thrombus. When added to the totality of available studies, this study demonstrates that the effectiveness of DOACs in LV thrombus remains uncertain. Randomized clinical trials are needed. PMID: 33191781 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 15, 2020 Category: Drugs & Pharmacology Authors: Willeford A, Zhu W, Stevens C, Thomas IC Tags: Ann Pharmacother Source Type: research

Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment.
PMID: 33185108 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 13, 2020 Category: Drugs & Pharmacology Authors: Danjuma M, Elgara M, Al-Hattab F, Abaro R, Elzouki AN Tags: Ann Pharmacother Source Type: research

The Implication of Conduction Abnormalities on Pharmacotherapy Decision-making.
PMID: 33185109 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 13, 2020 Category: Drugs & Pharmacology Authors: Noel ZR, Flannery AH Tags: Ann Pharmacother Source Type: research

Management of Atrial Fibrillation Following Cardiac Surgery: Observational Study and Development of a Standardized Protocol.
CONCLUSIONS AND RELEVANCE: POAF management was heterogeneous at our institution. This article highlights the need for clear practice guidelines based on large prospective studies to provide care according to best practices. PMID: 33185128 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 13, 2020 Category: Drugs & Pharmacology Authors: Bruggmann C, Astaneh M, Lu H, Tozzi P, Ltaief Z, Voirol P, Sadeghipour F Tags: Ann Pharmacother Source Type: research

Impact of a Pharmacist-Led Intensive Care Unit Sleep Improvement Protocol on Sleep Duration and Quality.
CONCLUSION AND RELEVANCE: A sleep protocol that incorporated novel elements led to objective and subjective improvements in ICU sleep duration and quality. Application of this study may result in increased utilization of sleep protocols and pharmacist involvement. PMID: 33166192 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 9, 2020 Category: Drugs & Pharmacology Authors: Andrews JL, Louzon PR, Torres X, Pyles E, Ali MH, Du Y, Devlin JW Tags: Ann Pharmacother Source Type: research

A Pharmacokinetic-Pharmacodynamic Analysis to Dose Optimize Daptomycin in Vancomycin-Resistant Enterococcus faecium: Is the Answer Fixed Dosing or Lowering Breakpoints?
CONCLUSION AND RELEVANCE: Fixed doses were more likely to achieve a fAUC/MIC of 27.43 than weight-based doses up to 12 mg/kg/d. However, fixed doses necessary for 90% PTA against SDD isolates with higher MICs were associated with elevated risks of toxicity. A reevaluation of Clinical Laboratory Standards Institute breakpoints may need to be considered, with an emphasis on lowering the SDD breakpoint to 1 mg/L. PMID: 33147997 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 4, 2020 Category: Drugs & Pharmacology Authors: Butterfield-Cowper JM Tags: Ann Pharmacother Source Type: research

Netarsudil for the Treatment of Open-Angle Glaucoma and Ocular Hypertension: A Literature Review.
CONCLUSIONS: Evidence demonstrates that netarsudil is inferior to prostaglandin analogues and noninferior to topical β-blockers in the treatment of OAG and OHT. Hyperemia is a common adverse drug reaction, which often resolves after medication discontinuation. Additional phase III clinical trials and evidence-based guidelines are necessary to determine netarsudil's position in OAG and OHT management. PMID: 33148002 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 4, 2020 Category: Drugs & Pharmacology Authors: Gonzalez LE, Boylan PM Tags: Ann Pharmacother Source Type: research

Economic Burden of Osteoporosis-Related Fractures in the US Medicare Population.
CONCLUSION AND RELEVANCE: The current findings suggest a significant economic burden associated with fractures. Early identification and treatment of patients at high risk for fractures is of paramount importance for secondary prevention and reduced mortality. PMID: 33148010 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 4, 2020 Category: Drugs & Pharmacology Authors: Williams SA, Daigle SG, Weiss R, Wang Y, Arora T, Curtis JR Tags: Ann Pharmacother Source Type: research

Off-label Use for Direct Oral Anticoagulants: Valvular Atrial Fibrillation, Heart Failure, Left Ventricular Thrombus, Superficial Vein Thrombosis, Pulmonary Hypertension-a Systematic Review.
CONCLUSION: DOACs can be considered for AF complicated by VHD except for mitral stenosis or mechanical valve replacement. DOACs (especially rivaroxaban) are considered as an alternative therapy for SVT and CTEPH. Further prospective studies for DOAC uses are needed for HF or LVT. PMID: 33148014 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 4, 2020 Category: Drugs & Pharmacology Authors: Brokmeier H, Kido K Tags: Ann Pharmacother Source Type: research

Osilodrostat: A Novel Steroidogenesis Inhibitor to Treat Cushing's Disease.
Abstract OBJECTIVE: To review data on efficacy and safety of osilodrostat (Isturisa), a novel oral steroidogenesis inhibitor for treatment of Cushing's disease (CD), a life-threatening endocrine disorder. DATA SOURCES: A PubMed/CINAHL search from inception to September 25, 2020, was performed using the following keywords: osilodrostat, 11-beta hydroxylase, pituitary, ACTH hypersecretion, and Cushing's disease. STUDY SELECTION AND DATA EXTRACTION: Phase 2 and 3 clinical trials and supplementary documents investigating osilodrostat were obtained from a primary literature search, the manufacturer's website,...
Source: The Annals of Pharmacotherapy - November 3, 2020 Category: Drugs & Pharmacology Authors: Dougherty JA, Desai DS, Herrera JB Tags: Ann Pharmacother Source Type: research

Rethinking Carbapenems: A Pharmacokinetic Approach for Antimicrobial Selection in Infected Necrotizing Pancreatitis.
CONCLUSIONS: Noncarbapenem antipseudomonals, such as piperacillin/tazobactam and cefepime, are appropriate carbapenem-sparing options in INP, based on PK data, spectrum of activity, and risk of collateral damage. PMID: 33135457 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 2, 2020 Category: Drugs & Pharmacology Authors: Maguire C, Agrawal D, Daley MJ, Douglass E, Rose DT Tags: Ann Pharmacother Source Type: research

Ins and Outs: Perspectives of Inpatient Prescribing for Sacubitril/Valsartan.
Abstract Heart failure is a major public health concern with a rising prevalence and significant financial detriment. Although sacubitril/valsartan was shown to reduce the risk of death and hospitalization from heart failure in a contemporary cohort, it continues to remain substantially underutilized. A recent article in the Annals highlights the evidence behind inpatient initiation of sacubitril/valsartan. We provide further considerations and summarize the evidence for inpatient initiation of other guideline directed medical therapies. Overall, there is a need to improve methods to identify ideal populations and...
Source: The Annals of Pharmacotherapy - October 28, 2020 Category: Drugs & Pharmacology Authors: Gillette M, Bozkurt B Tags: Ann Pharmacother Source Type: research

Direct Oral Anticoagulants in Select Patients With Hypercoagulable Disorders.
CONCLUSIONS: The current body of evidence supports the use of select DOACs for the treatment of CAT. In contrast, DOAC use in patients with APS and hereditary thrombophilia should be avoided at this time. PMID: 33100017 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 26, 2020 Category: Drugs & Pharmacology Authors: Valanejad SM, Davis KA Tags: Ann Pharmacother Source Type: research

Impact of Obesity on Warfarin Reversal With Fixed-Dose Factor VIII Inhibitor Bypassing Activity (aPCC).
CONCLUSION AND RELEVANCE: When fixed-dose aPCC is used for warfarin reversal, obesity is associated with a significantly lower rate of INR reversal, without increased bleeding. This study adds to the limited amount of literature on aPCC dosing in obesity. PMID: 33094635 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 23, 2020 Category: Drugs & Pharmacology Authors: McKinney AL, Dailey LM, McMillen JC, Rowe AS Tags: Ann Pharmacother Source Type: research

Risk Factors for Gemcitabine-Induced Vascular Pain in Patients With Pancreatic Cancer.
CONCLUSIONS AND RELEVANCE: High gemcitabine dosages and lack of hot pack use were predictive factors for gemcitabine-induced vascular pain in patients with pancreatic cancer. Patients receiving gemcitabine treatment should apply a hot pack to the injection site. Scrupulous clinical attention is required for patients presenting with these risk factors to improve pain management. PMID: 33094647 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 23, 2020 Category: Drugs & Pharmacology Authors: Ishida S, Makihara Y, Watanabe H, Nakashima T, Nagata K, Suetsugu K, Tsuji T, Hata K, Ikeda M, Ikebe M, Minami H, Watanabe H, Nakata K, Nakamura M, Egashira N, Ieiri I Tags: Ann Pharmacother Source Type: research

Direct Oral Anticoagulant Use in Chronic Kidney Disease and Dialysis Patients With Venous Thromboembolism: A Systematic Review of Thrombosis and Bleeding Outcomes.
CONCLUSION: Apixaban may be used cautiously as an alternative in acute VTE treatment in severe CKD patients. Insufficient evidence is available to suggest the use of dabigatran and rivaroxaban in this patient population. The benefit of using DOACs in this population for VTE treatment should be weighed against the potential bleeding risk in patients with CKD. PMID: 33073581 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 19, 2020 Category: Drugs & Pharmacology Authors: Cheung CYS, Parikh J, Farrell A, Lefebvre M, Summa-Sorgini C, Battistella M Tags: Ann Pharmacother Source Type: research

Use of Cannabis and Cannabinoids in Patients With Cancer.
CONCLUSIONS: Current evidence for use of medical cannabis and cannabinoids in cancer patients is weak. However, healthcare professionals are in an ideal role to monitor and educate patients using medical cannabis and cannabinoids. PMID: 33070617 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 17, 2020 Category: Drugs & Pharmacology Authors: Sawtelle L, Holle LM Tags: Ann Pharmacother Source Type: research

Impact of Extended-Interval Versus Standard Dosing of Zoledronic Acid on Skeletal Events in Non-Small-Cell Lung Cancer and Small-Cell Lung Cancer Patients With Bone Metastases.
CONCLUSION AND RELEVANCE: This is the first report examining extended-interval dosing of zoledronic acid in metastatic lung cancer. Incidence and time to SRE at 1 year were similar. This extended-interval dosing may be safe and reasonable for patients with lung cancer with bone metastases. PMID: 33070623 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 17, 2020 Category: Drugs & Pharmacology Authors: Tam AH, Schepers AJ, Qin A, Nachar VR Tags: Ann Pharmacother Source Type: research

Sacituzumab Govitecan-hziy: An Antibody-Drug Conjugate for the Treatment of Refractory, Metastatic, Triple-Negative Breast Cancer.
CONCLUSION: Sacituzumab govitecan is a novel targeted treatment with promising activity in mTNBC. PMID: 33070624 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 17, 2020 Category: Drugs & Pharmacology Authors: Seligson JM, Patron AM, Berger MJ, Harvey RD, Seligson ND Tags: Ann Pharmacother Source Type: research

Vitamin D Supplementation During Statin Rechallenge in Patients With a History of Intolerance.
PMID: 33054316 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 15, 2020 Category: Drugs & Pharmacology Authors: Compton ALP, Pepin MJ, Katzenberger DR, Kemp DW, Brown JN Tags: Ann Pharmacother Source Type: research

Systematic Review and Meta-analysis of Pirfenidone, Nintedanib, and Pamrevlumab for the Treatment of Idiopathic Pulmonary Fibrosis.
CONCLUSION AND RELEVANCE: This MA provided encouraging results on pamrevlumab efficacy in slowing the decline in FVC compared with pirfenidone and nintedanib. Actually, in phase 3, it could become a potential IPF treatment. PMID: 33054319 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 15, 2020 Category: Drugs & Pharmacology Authors: Di Martino E, Provenzani A, Vitulo P, Polidori P Tags: Ann Pharmacother Source Type: research

Efficacy of Methocarbamol for Acute Pain Management in Young Adults With Traumatic Rib Fractures.
CONCLUSION AND RELEVANCE: This is the first study to evaluate the impact of methocarbamol on reducing opioid requirements. Given the risks associated with opioids, use of methocarbamol as an analgesia-optimizing, opioid-sparing multimodal agent may be reasonable. PMID: 33045839 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 12, 2020 Category: Drugs & Pharmacology Authors: Deloney LP, Smith Condeni M, Carter C, Privette A, Leon S, Eriksson EA Tags: Ann Pharmacother Source Type: research

Safety of Single-Dose Oral Cefixime, Intramuscular Ceftriaxone, or Intramuscular Gentamicin for the Treatment of Gonorrhea: A Systematic Review and Meta-analysis.
CONCLUSIONS: The use of single-dose cefixime, ceftriaxone, and gentamicin-based regimens for treatment of gonorrhea appears to be safe and acceptable for use in practice. PMID: 33043676 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 10, 2020 Category: Drugs & Pharmacology Authors: Dresser J, Wilby KJ Tags: Ann Pharmacother Source Type: research

An Evaluation of Continuous Infusion Rocuronium for Sustained Neuromuscular Blockade in Critically Ill Adults.
CONCLUSION AND RELEVANCE: In ICU patients with MOF, continuous rocuronium infusions were associated with deep levels of paralysis and prolonged recovery times. If neuromuscular blockade is required for critically ill patients, alternative strategies could be considered. PMID: 33043678 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 10, 2020 Category: Drugs & Pharmacology Authors: Groetzinger LM, Hutchins AT, Rivosecchi RM Tags: Ann Pharmacother Source Type: research

Comment: Assessment of Acute Kidney Injury in Neurologically Injured Patients Receiving Hypertonic Sodium Chloride: Does Chloride Load Matter?
PMID: 33025793 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 7, 2020 Category: Drugs & Pharmacology Authors: Gueret G, Le Maguet P, Lefebvre P, Fabre R Tags: Ann Pharmacother Source Type: research

Impact of Hyperoncotic Albumin on Duration of Vasopressor Support inSeptic Shock: A PropensityScore-Matched Analysis.
CONCLUSION AND RELEVANCE: Albumin use in septic shock was not associated with additional days alive and free of vasopressors or in-hospital mortality. The finding of fewer ventilator- and ICU-free days may reflect selection of patients who were critically ill for longer periods of time before or after albumin administration. Additional study is needed to clarify the impact that timing may have on the effectiveness of albumin in septic shock. PMID: 33016080 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 4, 2020 Category: Drugs & Pharmacology Authors: Flannery AH, Owen GD, Coz A, Thompson Bastin ML, Patel K Tags: Ann Pharmacother Source Type: research

Intravenous Zanamivir: A Viable Option for Critically Ill Patients With Influenza.
CONCLUSIONS: The available information suggests that the intravenous formulation of zanamivir offers a viable alternative treatment for critically ill patients with influenza, especially when resistance to other agents is present. PMID: 33016090 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 4, 2020 Category: Drugs & Pharmacology Authors: Slain D Tags: Ann Pharmacother Source Type: research

Sustained Virological Response of Patients Hospitalized Compared With Those Not Hospitalized During Treatment for Hepatitis C Virus With Direct-Acting Antivirals.
CONCLUSION AND RELEVANCE: Patients hospitalized during DAA treatment for HCV had reduced rates of SVR. This reduced SVR rate may be driven by inpatient mortality and severity of liver disease. Patient education to bring home supply of medication for use during admission is an effective intervention. PMID: 33016095 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 4, 2020 Category: Drugs & Pharmacology Authors: Gentene AJ, Bell AM, Pence A, Thomas K, Jakubecz C, Stacy E, Woolf B, Guido MR, Mueller EW, Sherman KE Tags: Ann Pharmacother Source Type: research

Reply: Assessment of Acute Kidney Injury in Neurologically Injured Patients Receiving Hypertonic Sodium Chloride: Does Chloride Load Matter?
PMID: 33016087 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - October 2, 2020 Category: Drugs & Pharmacology Authors: Sigmon J, May C Tags: Ann Pharmacother Source Type: research

Novel Therapies in Acute Migraine Management: Small-Molecule Calcitonin Gene-Receptor Antagonists and Serotonin 1F Receptor Agonist.
CONCLUSIONS: Based on available data, ubrogepant, rimegepant, and lasmiditan should be reserved as second-line therapy and may be safe in patients with cardiovascular risk. Lasmiditan's adverse effect profile may limit its use. PMID: 32993366 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 28, 2020 Category: Drugs & Pharmacology Authors: Joyner KR, Morgan KW Tags: Ann Pharmacother Source Type: research

Heplisav-B: A Hepatitis B Vaccine With a Novel Adjuvant.
CONCLUSION: HepB-CpG has been shown to be as immunogenic as Engerix-B; however, long-term safety and persistence of immune memory has yet to be established. PMID: 32988213 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 27, 2020 Category: Drugs & Pharmacology Authors: Champion CR Tags: Ann Pharmacother Source Type: research

Apixaban Levels Detected in a Patient 10 Days From Last Known Dose While Experiencing Acute on Chronic Kidney Disease.
PMID: 32988217 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 27, 2020 Category: Drugs & Pharmacology Authors: Robinson ZS, Harper NG Tags: Ann Pharmacother Source Type: research

The Association of ICH Exclusion Criteria With Mortality and Disability Rates in ICH Patients Receiving 4F-PCC for Anticoagulation Reversal.
Abstract BACKGROUND: Intracranial hemorrhage (ICH) exclusion criteria in the landmark four-factor prothrombin complex concentrate (4F-PCC) trial have not been incorporated into clinical practice and incremental predictive ability is unknown. OBJECTIVES: Evaluate the association of meeting at least 1 ICH exclusion criterion with the composite end point in-hospital mortality and modified Rankin Scale [mRS] score 5 or 6. Determine the number and combination of criteria associated with poor outcomes. METHODS: Retrospective review of adult ICH patients who received 4F-PCC for anticoagulant reversal. Patient d...
Source: The Annals of Pharmacotherapy - September 23, 2020 Category: Drugs & Pharmacology Authors: Zaeem M, Porter BA, Delibert S, Jones CMC, Acquisto NM Tags: Ann Pharmacother Source Type: research

Effectiveness of a Calculation-Free Weight-Based Unfractionated Heparin Nomogram With Anti-Xa Level Monitoring Compared With Activated Partial Thromboplastin Time.
CONCLUSION AND RELEVANCE: This study demonstrated that anti-Xa UFH monitoring integrated with a calculation-free nomogram results in faster time to therapeutic anticoagulation and fewer dose adjustments compared with aPTT monitoring with manual calculations. PMID: 32964730 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - September 22, 2020 Category: Drugs & Pharmacology Authors: Kindelin NM, Anthes AM, Providence SM, Zhao X, Aspinall SL Tags: Ann Pharmacother Source Type: research