Onasemnogene Abeparvovec-xioi: Gene Therapy for Spinal Muscular Atrophy.
Abstract Objective: To review the efficacy and safety of onasemnogene abeparvovec-xioi (Zolgensma) in the treatment of spinal muscular atrophy (SMA). Data Sources: An English-language literature search of PubMed, MEDLINE, and Ovid (1946 to December 2019) was completed using the terms onasemnogene, AVXS-101, and spinal muscular atrophy. Manufacturer prescribing information, article bibliographies, and data from ClinicalTrials.gov were incorporated in the reviewed data. Study Selection/Data Extraction: All studies registered on ClinicalTrials.gov were incorporated in the reviewed data. Data Synthesis: Onasemnogene i...
Source: The Annals of Pharmacotherapy - March 23, 2020 Category: Drugs & Pharmacology Authors: Stevens D, Claborn MK, Gildon BL, Kessler TL, Walker C Tags: Ann Pharmacother Source Type: research

Association Between Antipsychotics and Osteoporosis Based on Real-World Data.
Conclusion and Relevance: Real-world data show no association between antipsychotic use and the onset of osteoporosis. Further pharmacoepidemiological studies are needed for causality assessment. PMID: 32186394 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 18, 2020 Category: Drugs & Pharmacology Authors: Yokoyama S, Wakamoto S, Tanaka Y, Nakagawa C, Hosomi K, Takada M Tags: Ann Pharmacother Source Type: research

Niraparib for the Treatment of Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.
Abstract Objective: To review the efficacy and safety of niraparib for the treatment of recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer (OC, FTC, and PPC). Data Sources: A literature search via MEDLINE through PubMed from August 2013 to January 2020 was performed using the key terms niraparib, PARP inhibitors, ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. Study Selection and Data Extraction: Completed and ongoing trials were identified through a review of the website trial registry https://www.clinicaltrials.gov . Data Synthesis: In a phase III, double-blind clin...
Source: The Annals of Pharmacotherapy - March 16, 2020 Category: Drugs & Pharmacology Authors: Kerliu L, Myruski S, Bhatti A, Soni P, Petrosius P, Pervanas HC, Horton ER Tags: Ann Pharmacother Source Type: research

Outcomes Associated With Resuming Direct Oral Anticoagulant Therapy Following Admission for a Gastrointestinal Bleed.
Conclusion and Relevance: Resuming anticoagulation within 7 days of admission for an index GIB was not associated with a recurrent GIB within 90 days of discharge. PMID: 32141301 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 6, 2020 Category: Drugs & Pharmacology Authors: Valanejad SM, Davis KA, Nisly SA Tags: Ann Pharmacother Source Type: research

Treating Psoriasis With Halobetasol Propionate and Tazarotene Combination: A Review of Phase II and III Clinical Trials.
Conclusions: HP/TAZ combination lotion is efficacious and safe for plaque psoriasis treatment, with more patients achieving end points and fewer side effects than in HP, TAZ, or vehicle-treated controls. Drug synergy may play a role. Importantly, patient adherence to a once-daily combinational therapy is likely to contribute to efficacy. PMID: 32126800 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 4, 2020 Category: Drugs & Pharmacology Authors: Ramachandran V, Bertus B, Bashyam AM, Feldman SR Tags: Ann Pharmacother Source Type: research

Ethical, Economic, Societal, Clinical, and Pharmacology Uncertainties Associated With Milasen and Other Personalized Drugs.
PMID: 32126811 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 4, 2020 Category: Drugs & Pharmacology Authors: Amariles P, Madrigal-Cadavid J Tags: Ann Pharmacother Source Type: research

Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials.
Conclusion: Moderate and high dose of CT could accelerate hearing improvement in SSHL. PMID: 32126823 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 4, 2020 Category: Drugs & Pharmacology Authors: Li J, Ding L Tags: Ann Pharmacother Source Type: research

Looking Back at US Pharmacy's Past to Help Discern Its Future.
Conclusion: Most of the predictions for the future of pharmacy from the past 3 decades materialized, with some still in progress (reimbursement for pharmacy services), whereas others manifested in unexpected ways (transition from shortage to excess of pharmacists). Current forces shaping pharmacy include, but are not limited to, growing spending and use of specialty drugs, automation of pharmacy operations, growth of pharmacy in the digital health enterprise, and growing consumer interest in the use of analytical pharmacy that tests drugs before dispensing. PMID: 32115996 [PubMed - as supplied by publisher] (Source: T...
Source: The Annals of Pharmacotherapy - March 1, 2020 Category: Drugs & Pharmacology Authors: Shcherbakova N, Desselle S Tags: Ann Pharmacother Source Type: research

Reply: Sodium-Glucose Cotransporters as Potential Therapeutic Targets in Patients With Type 1 Diabetes Mellitus: An Update on Phase 3 Clinical Trial Data.
PMID: 32115997 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 1, 2020 Category: Drugs & Pharmacology Authors: Patel KS, Carbone AM Tags: Ann Pharmacother Source Type: research

To Block or Not: Updates in Neuromuscular Blockade in Acute Respiratory Distress Syndrome.
Conclusions: The mortality benefit of NMBAs in ARDS has contradicting evidence with potentially serious adverse effects and notable controversies. PMID: 32111121 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 28, 2020 Category: Drugs & Pharmacology Authors: Mefford B, Donaldson JC, Bissell BD Tags: Ann Pharmacother Source Type: research

Exploration of an Association Between UFH Dosing Based on Estimated Blood Volume and Venous Thromboembolism and Bleeding in the Underweight and Critically Ill.
PMID: 32106684 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 28, 2020 Category: Drugs & Pharmacology Authors: Carter C, Betthauser KD, Peppard WJ Tags: Ann Pharmacother Source Type: research

Dose-Dependent Hyperkalemia Among Hospitalized, HIV-Infected Patients Receiving Sulfamethoxazole/Trimethoprim.
Abstract Background: Sulfamethoxazole-trimethoprim (SXT) therapy is commonly used in HIV-infected patients and is associated with hyperkalemia and elevated serum creatinine (SCr). Objective: The purpose of this study was to examine the frequency of hyperkalemia and elevated SCr in hospitalized, HIV-infected patients receiving SXT. Methods: This was a retrospective, single-center cohort study. HIV-infected hospitalized patients receiving a minimum of 3 consecutive days of SXT were included. Patients were grouped according to high dose (≥10 mg/kg/d) and low dose (
Source: The Annals of Pharmacotherapy - February 28, 2020 Category: Drugs & Pharmacology Authors: Caulder CR, Kocherla CS, Qureshi ZP, Magagnoli J, Bookstaver PB Tags: Ann Pharmacother Source Type: research

Comment: Sodium-Glucose Cotransporters as Potential Therapeutic Targets in Patients With Type 1 Diabetes Mellitus: An Update on Phase 3 Clinical Trial Data.
PMID: 32106686 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 28, 2020 Category: Drugs & Pharmacology Authors: Cumhur Cure M, Cure E Tags: Ann Pharmacother Source Type: research

Improved Glycemic Control Outcomes Regardless of Mental Health Disorders in a Pharmacist-Endocrinologist Diabetes Intense Medical Management (DIMM) "Tune Up" Clinic.
Conclusion and Relevance: In 6 months, both groups in the DIMM clinic achieved a statistically significant mean A1C reduction (over 2%) with no statistical or clinical difference in the magnitude of change between groups. Patients with T2D benefitted from the DIMM model and personalized visits with a pharmacist regardless of having a MH disorder. PMID: 32100551 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 26, 2020 Category: Drugs & Pharmacology Authors: Morello CM, Nguyen T, Tao L, Hirsch JD Tags: Ann Pharmacother Source Type: research

Management of Mantle Cell Lymphoma in the Era of Novel Oral Agents.
Conclusions: Recent study results are changing management of MCL. Although these data have complicated the picture of regimen selection, increasingly effective and tolerable therapy and additional anticipated data point to a brighter future for patients with MCL. PMID: 32079411 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 20, 2020 Category: Drugs & Pharmacology Authors: Buege MJ, Kumar A, Dixon BN, Tang LA, Pak T, Orozco J, Peterson TJ, Maples KT Tags: Ann Pharmacother Source Type: research

Standardized Volume Dosing Protocol of 23.4% Hypertonic Saline for Pediatric Critical Care: Initial Experience.
Abstract Background: Standardized volume dosing of 23.4% hypertonic saline (HTS) exists for adults, but the concentration, dosing and administration of HTS in pediatrics is variable. With emerging pediatric experience of 23.4% HTS, a standard volume dose approach may be helpful. Objective: To describe initial experience with a standardized 23.4% HTS weight-based volume dosing protocol of 10, 20, or 30 mL in the pediatric intensive care unit. Methods: Standard volume doses of 23.4% HTS were developed from weight dosing equivalents of 3% HTS. Pre and post sodium and intracranial pressure (ICP) measurements were comp...
Source: The Annals of Pharmacotherapy - February 18, 2020 Category: Drugs & Pharmacology Authors: Cummings BM, Fernandes ND, Parker LF, Murphy SA, Yager PH Tags: Ann Pharmacother Source Type: research

Secukinumab-Induced Acute Autoimmune Hemolytic Anemia.
ine A PMID: 32062981 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 17, 2020 Category: Drugs & Pharmacology Authors: Sébastien R, Claire V, Thierry V, Marine A Tags: Ann Pharmacother Source Type: research

The Revised Starling Equation: The Debate of Albumin Versus Crystalloids Continues.
Conclusions: The principles underlying the revised Starling equation in conjunction with data from radiolabeled studies of albumin and large clinical trials demonstrate that albumin does not have the perceived degree of plasma expansion or duration of intravascular retention beyond crystalloid solutions predicted by the classic Starling equation. PMID: 32059617 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 14, 2020 Category: Drugs & Pharmacology Authors: Erstad BL Tags: Ann Pharmacother Source Type: research

Extravasation of Noncytotoxic Drugs.
Conclusions: Extravasations still contribute to significant morbidity and mortality. A good knowledge of risk factors and the implementation of easily and quickly accessible standardized care protocols are 2 key elements in both prevention and treatment of extravasations. PMID: 32054312 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2020 Category: Drugs & Pharmacology Authors: David V, Christou N, Etienne P, Almeida M, Roux A, Taibi A, Mathonnet M Tags: Ann Pharmacother Source Type: research

Intranasal Glucagon: A New Way to Treat Hypoglycemic Emergencies.
Conclusion: IN glucagon is a safe, effective, easy to use, needle-free treatment option for severe hypoglycemia. PMID: 32052651 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 13, 2020 Category: Drugs & Pharmacology Authors: Lowe RN, Trujillo JM Tags: Ann Pharmacother Source Type: research

Real-World Evaluation of Dosing in Patients Converted From Insulin Glargine (Lantus) to Insulin Glargine (Basaglar).
Abstract Background: Basaglar, insulin glargine (BGlar; Eli Lilly, Indianapolis, IN), a follow-on biologic, was developed after the patent for Lantus, insulin glargine (LGlar; Sanofi-Aventis, Paris, France) expired. Objective: To compare the dosing and hemoglobin A1C (A1C)-lowering effects of BGlar compared with LGlar in a real-world setting. Methods: Adult patients, at 5 clinics, with type 1 (T1DM) or type 2 diabetes mellitus (T2DM) who were converted from LGlar to BGlar were included in this retrospective observational study. The primary outcome compared mean basal insulin dose (U/d) from the date of conversion ...
Source: The Annals of Pharmacotherapy - February 10, 2020 Category: Drugs & Pharmacology Authors: Pitlick JM, Bryant GA, Daly MW, Koenigsfeld CF, Lehman N, Brueggen K, McCormick A, Wellington K Tags: Ann Pharmacother Source Type: research

Current System of Overseeing Drug Trials in Developing Countries by the FDA Is Dangerous.
Abstract Clinical research used to substantiate Food and Drug Administration (FDA) drug approval is increasingly being conducted overseas. One of the enticements to move overseas is unequal oversight by the FDA, and these differences can result in poor quality research and human subject risk. Downstream, patients, clinicians, and payers of health care can be harmed by inaccuracies in the new drug approval process. The need of the hour is to bridge the gap in the standards by ensuring that the investigators in the developing countries adhere to the same quality standards as the domestic investigators. PMID: 32...
Source: The Annals of Pharmacotherapy - February 10, 2020 Category: Drugs & Pharmacology Authors: White CM Tags: Ann Pharmacother Source Type: research

Calcitonin Gene-Related Peptide Antagonists for the Prevention of Migraine: Highlights From Pivotal Studies and the Clinical Relevance of This New Drug Class.
Conclusions: Monoclonal antibodies inhibiting CGRP are effective in migraine prophylaxis with minimal adverse effects. Targeting CGRP is a novel clinical strategy in managing migraine. PMID: 32019317 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 5, 2020 Category: Drugs & Pharmacology Authors: Arca K, Reynolds J, Sands KA, Shiue HJ Tags: Ann Pharmacother Source Type: research

A Review of Deflazacort for Patients With Duchenne Muscular Dystrophy.
Conclusions: Deflazacort presents an additional, FDA-approved corticosteroid option for patients that offers improved quality of life for DMD patients. However, there is weak evidence to support these benefits; a full risk-benefit analysis considering adverse events, efficacy, cost, and previous trials of steroid therapy is necessary when selecting therapy. Further research will help clarify deflazacort's optimal dose, duration of treatment, and impact on quality of life. PMID: 32019318 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 4, 2020 Category: Drugs & Pharmacology Authors: Bylo M, Farewell R, Coppenrath VA, Yogaratnam D Tags: Ann Pharmacother Source Type: research

The Tasmanian Atrial Fibrillation Study (TAFS): Differences in Stroke Prevention According to Sex.
Conclusion and Relevance: Female patients with a high stroke risk were less likely to receive guideline-recommended treatment. This study provides new information on prescribing trends within the Australian setting and highlights the opportunity to improve the management of female patients with AF and 1 or more additional stroke risk factors. PMID: 32019321 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - February 4, 2020 Category: Drugs & Pharmacology Authors: Pilcher SM, Alamneh EA, Chalmers L, Bereznicki LR Tags: Ann Pharmacother Source Type: research

Efficacy of Conversion to Aflibercept for Diabetic Macular Edema Previously Refractory to Bevacizumab or Ranibizumab: A Meta-analysis of High-Quality Nonrandomized Studies.
Abstract Background: Aflibercept has been widely used in treating diabetic macular edema (DME). However, the effect of aflibercept in treating DME refractory to bevacizumab or ranibizumab has not been well established. Objective: To assess the therapeutic effect of switching from bevacizumab or ranibizumab to aflibercept in the treatment of refractory DME. Methods: Relevant studies were searched from 3 databases: the Cochrane Library, PubMed, and Web of Science. Data on changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), and adverse events within the follow-up period were collected and...
Source: The Annals of Pharmacotherapy - January 31, 2020 Category: Drugs & Pharmacology Authors: Xiao K, Li FZ, Liang SZ, Wang J, Qian C, Wan GM Tags: Ann Pharmacother Source Type: research

Dietary Supplements Pose Real Dangers to Patients.
Abstract The Dietary Supplement Health and Education Act led to a flood of poor-quality dietary supplements. The Food and Drug Administration's (FDA's) jurisdiction is limited to removing products proven unsafe, rather than prospectively assessing them for quality manufacturing. With so many products available, there is very little FDA oversight until reports of patient harm occur. Microbial and heavy metal contamination, adulteration with synthetic drugs (including drugs banned from the United States), substituting herbs, and fraudulently specifying ingredients on the label have all occurred. Clinicians should co...
Source: The Annals of Pharmacotherapy - January 24, 2020 Category: Drugs & Pharmacology Authors: White CM Tags: Ann Pharmacother Source Type: research

Impact of an Antimicrobial Stewardship Team on Reducing Antiretroviral Medication Errors.
This study assessed the impact of an antimicrobial stewardship (ASP) team intervention on reducing the rate of ARV therapy errors in patients admitted to an academic medical center. Methods: This observational, retrospective study included patients who received ARV therapy from June 2016 to December 2017. The primary outcome was evaluation of ASP team performance in detecting ARV medication errors in the inpatient setting. Errors were further categorized by type (interaction, dosing, regimen). The Mann-Whitney U test and χ2 tests were utilized to analyze continuous and categorical data, respectively. Results: Medicatio...
Source: The Annals of Pharmacotherapy - January 24, 2020 Category: Drugs & Pharmacology Authors: Nimarko K, Bandali A, Bias TE, Mindel S Tags: Ann Pharmacother Source Type: research

Request for an Andexxa Value Analysis.
Abstract This perspective is a formal request to the American College of Cardiology and American Heart Association (ACC/AHA) to perform a value analysis on andexanet (Andexxa) similar to what was completed for the PCSK9 inhibitors in the 2018 ACC/AHA Blood Cholesterol guidelines. Based on the safety and efficacy concerns of andexanet alfa, a value statement in and or as an addendum to society guidelines is vital considering the high cost of therapy. In this era of ever-increasing health care costs, every clinician, health system, national society, insurer, and pharmaceutical company should work to be good stewards...
Source: The Annals of Pharmacotherapy - January 23, 2020 Category: Drugs & Pharmacology Authors: Yin E, McConnell KJ Tags: Ann Pharmacother Source Type: research

Pharmacokinetics of Trastuzumab After Subcutaneous and Intravenous Administration in Obese Patients.
Conclusion and Relevance: Our study suggests that trastuzumab SC fixed dose of 600 mg is not equivalent to IV administration, especially in obese patients. An adequate trastuzumab exposure in this population needs patient weight-adjusted IV dosage in the first administration. The clinical relevance of these findings remains to be elucidated, and further research, including larger controlled trials, is warranted. PMID: 31971005 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 23, 2020 Category: Drugs & Pharmacology Authors: González García J, Gutiérrez Nicolás F, Ramos Díaz R, Nazco Casariego GJ, Viña Romero MM, Llabres Martinez M, Llanos Muñoz M, Batista López JN, Jiménez Sosa A, Ceballos Lenza I, Cruz Jurado J Tags: Ann Pharmacother Source Type: research

Pharmacological Treatment for Obesity in Adults: An Umbrella Review.
Conclusions: All pharmacological therapies included in this review are superior to placebo in reducing weight. Clinicians should consider patient comorbidities and risk of adverse events when recommending medications for weight loss. PMID: 31958967 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 20, 2020 Category: Drugs & Pharmacology Authors: Khalil H, Ellwood L, Lord H, Fernandez R Tags: Ann Pharmacother Source Type: research

Association of Antibiotic Treatment Duration With Recurrence of Uncomplicated Urinary Tract Infection in Pediatric Patients.
Conclusions and Relevance: Antibiotic treatment duration was not significantly associated with recurrence of uncomplicated UTI in a national pediatric cohort. Results provide support for shorter-course treatment, consistent with antimicrobial stewardship efforts. PMID: 31958969 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 20, 2020 Category: Drugs & Pharmacology Authors: Afolabi TM, Goodlet KJ, Fairman KA Tags: Ann Pharmacother Source Type: research

Narrative Review of Controversies Involving Vasopressin Use in Septic Shock and Practical Considerations.
Conclusion: Vasopressin should remain second-line adjunct to norepinephrine to augment mean arterial pressures. Dosing should be initiated at 0.03 U/min, and higher doses offer minimal benefit. There are conflicting data on the impact of weight on vasopressin response. Studies have failed to show renal benefit with vasopressin use or an interaction with corticosteroid therapy. PMID: 31958982 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 20, 2020 Category: Drugs & Pharmacology Authors: Der-Nigoghossian C, Hammond DA, Ammar MA Tags: Ann Pharmacother Source Type: research

Associations Between Obesity and the Effectiveness of Anti-Tumor Necrosis Factor- α Agents in Inflammatory Bowel Disease Patients: A Literature Review and Meta-analysis.
Conclusion and Relevance: In our meta-analysis, obesity was associated with the inferior response of anti-TNF treatments in UC patients. Clinicians should be aware that obese UC patients may require higher doses in anti-TNF treatment. PMID: 31955605 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 19, 2020 Category: Drugs & Pharmacology Authors: Dai ZH, Xu XT, Ran ZH Tags: Ann Pharmacother Source Type: research

Adrenal Insufficiency and Response to Stress Dose Hydrocortisone in Patients With Cirrhosis and Vasopressor Dependency Using Cirrhosis-Specific Cortisol Thresholds.
Abstract Background: Cortisol thresholds defining adrenal insufficiency (AI) in some cirrhosis-specific studies differ from those recommended by the SCCM/ESICM (Society of Critical Care Medicine/European Society of Intensive Care Medicine) guidelines, which may influence treatment decisions. Objective: To determine if stress-dose hydrocortisone (HC) improves outcomes in vasopressor-dependent patients meeting cirrhosis-specific criteria for AI. Methods: In this retrospective study, AI was defined using criteria from 2 studies in critically ill cirrhosis patients showing mortality reduction with HC (random cortisol
Source: The Annals of Pharmacotherapy - January 12, 2020 Category: Drugs & Pharmacology Authors: Vu T, Vallabh M, Laine G Tags: Ann Pharmacother Source Type: research

Effectiveness, Safety, and Costs of Dolutegravir/Abacavir/Lamivudine Single-Tablet Regimen in a Real-Life Cohort of HIV-1 Adult Infected Patients.
Abstract Background: Real-life data on single-tablet regimen (STR) dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) is scarce, and concerns about DTG neuropsychiatric adverse events (NP-AEs) have recently arisen. Objective: To explore the effectiveness and safety, in particular NP-AEs, of DTG/ABC/3TC in a cohort of HIV-1 adult infected patients. Pill burden, adherence to this STR, and the impact of switching on costs were also evaluated. Methods: This was an observational, retrospective study. The study population included antiretroviral therapy (ART)-naive and treatment-experienced (TE) patients who started DTG/ABC...
Source: The Annals of Pharmacotherapy - January 8, 2020 Category: Drugs & Pharmacology Authors: Rodriguez-Gonzalez CG, Chamorro-de-Vega E, Ortega-Navarro C, Alonso R, Herranz-Alonso A, Sanjurjo-Saez M Tags: Ann Pharmacother Source Type: research

Alirocumab-Induced Hyperlipasemia and Hyperamylasemia.
PMID: 31902215 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 5, 2020 Category: Drugs & Pharmacology Authors: Alkhatib AA, Anglade P Tags: Ann Pharmacother Source Type: research

Noninvasive Fibrosis Assessment in Acute Viral Hepatitis C Infection.
PMID: 31902216 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 5, 2020 Category: Drugs & Pharmacology Authors: Hynicka LM, Cervino L, Burgess LA Tags: Ann Pharmacother Source Type: research

Medications Used Routinely in Primary Care to be Dose-Adjusted or Avoided in People With Chronic Kidney Disease: Results of a Modified Delphi Study.
Conclusion and Relevance: We have developed a concise list of 24 medications commonly used in primary care that should be dose-adjusted or avoided in people with CKD to reduce harm. This list incorporates new and frequently prescribed medications and will inform an updated, easy to access source for primary care providers. PMID: 31896276 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 2, 2020 Category: Drugs & Pharmacology Authors: Taji L, Battistella M, Grill AK, Cunningham J, Hemmelgarn BL, Quinn KM, Thomas A, Brimble KS Tags: Ann Pharmacother Source Type: research

Bremelanotide: New Drug Approved for Treating Hypoactive Sexual Desire Disorder.
Conclusion: Bremelanotide is a subcutaneous injection that can be administered as needed approximately 45 minutes prior to sexual activity. Bremelanotide is safe and has limited drug-drug interactions, including no clinically significant interactions with ethanol. Prescribing guidelines recommend no more than 1 dose in 24 hours and no more than 8 doses per month. Individuals should discontinue use after 8 weeks without benefit. PMID: 31893927 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 1, 2020 Category: Drugs & Pharmacology Authors: Mayer D, Lynch SE Tags: Ann Pharmacother Source Type: research

Comparison of Hypoglycemia and Safety Outcomes With Long-Acting Insulins Versus Insulin NPH in Pregestational and Gestational Diabetes.
Abstract Background: Current guidelines from the American College of Obstetricians and Gynecologists recommend insulin as the standard therapy for treatment of pregestational and gestational diabetes (PGDM and GDM). However, the guidelines do not specify which type(s) of insulin to utilize. Additionally, there are limited published data regarding safety parameters of insulin in this population. Objective: To evaluate if insulin glargine or detemir (long-acting insulin) results in less hypoglycemia, hospitalizations, or delivery complications compared with intermediate-acting insulin neutral protamine Hagedorn (NPH...
Source: The Annals of Pharmacotherapy - January 1, 2020 Category: Drugs & Pharmacology Authors: Sleeman A, Odom J, Schellinger M Tags: Ann Pharmacother Source Type: research

The Influence of Different Triazole Antifungal Agents on the Pharmacokinetics of Cyclophosphamide.
Conclusions and Relevance: Ketoconazole had the greatest effect on the PK of cyclophosphamide among the 3 triazole antifungals. Our study provides clues that the toxicity and adverse drug reactions that are associated with cyclophosphamide should be closely monitored when coadministered with ketoconazole. PMID: 31893943 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 1, 2020 Category: Drugs & Pharmacology Authors: Cai T, Liao Y, Chen Z, Zhu Y, Qiu X Tags: Ann Pharmacother Source Type: research

Acknowledgments to AOP Peer Reviewers November 1, 2018 through October 30, 2019.
Authors: PMID: 31766873 [PubMed - in process] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 28, 2019 Category: Drugs & Pharmacology Tags: Ann Pharmacother Source Type: research

Cirrhosis, Thrombosis, Finding FaXts about Doses: Dosing of Unfractionated Heparin for Venous Thromboembolism in Cirrhosis.
Conclusion and Relevance: Patients with severe cirrhosis required higher doses of heparin to achieve the same therapeutic AXA levels, but also tended to have higher rates of bleeding compared with less severe cirrhosis. These results represent further evidence of changes in heparin response as cirrhosis severity increases and may suggest that current monitoring methods are suboptimal in this patient population. PMID: 31766856 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 25, 2019 Category: Drugs & Pharmacology Authors: Franz ND, Brancaccio A, Robinson AC, Regal RE Tags: Ann Pharmacother Source Type: research

Trends of Use and Outcomes Associated With Glycoprotein-IIb/IIIa Inhibitors in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention.
Abstract Background: Glycoprotein IIb/IIIa inhibitors (GPIs) are a treatment option in the management of acute coronary syndromes (ACSs). Evidence supporting the use of GPIs predates trials establishing the benefits of P2Y12 inhibitors, routine early invasive therapy, and thrombectomy devices in patients with ACS. Objective: The aim of this study was to determine trends in GPI use and their associated outcomes in contemporary practice. Methods: We assessed GPI use in patients with ACS undergoing percutaneous coronary intervention (PCI) from the Melbourne Interventional Group registry (2005-2013). The primary endpo...
Source: The Annals of Pharmacotherapy - November 25, 2019 Category: Drugs & Pharmacology Authors: Gellatly RM, Connell C, Tan C, Andrianopoulos N, Ajani AE, Clark DJ, Nanayakkara S, Sebastian M, Brennan A, Freeman M, O'Brien J, Selkrig LA, Reid CM, Duffy SJ Tags: Ann Pharmacother Source Type: research

Evolution of Equations for Estimating Renal Function and Their Application to the Dosing of New Antimicrobials.
Conclusion: Recently approved antimicrobials utilizing the MDRD equation for renal dose adjustment will be interspersed with old and new antimicrobials utilizing the CG equation because of lack of singular guidance by the FDA. This requires pharmacists to be vigilant in evaluating drug labels to determine which equation is recommended and to understand the differences, strengths, and limitations of each equation. PMID: 31762287 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 24, 2019 Category: Drugs & Pharmacology Authors: Lew AK, Crass RL, Eschenauer G Tags: Ann Pharmacother Source Type: research

Patient Satisfaction With Extended International Normalized Ratio Follow-up Intervals in a Veteran Population.
Conclusion and Relevance: For patients currently stable on warfarin therapy, extending the INR follow-up interval up to 12 weeks or changing to a DOAC does not appear to improve patient satisfaction. PMID: 31752504 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 21, 2019 Category: Drugs & Pharmacology Authors: Schoen RR, Nagy MW, Porter AL, Margolis AR Tags: Ann Pharmacother Source Type: research

Bilateral Anterior and Intermediate Uveitis Associated With Omeprazole.
PMID: 31744307 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 19, 2019 Category: Drugs & Pharmacology Authors: Shifera AS Tags: Ann Pharmacother Source Type: research

Oral Semaglutide: First-in-Class Oral GLP-1 Receptor Agonist for the Treatment of Type 2 Diabetes Mellitus.
Conclusions: Oral semaglutide appears safe and effective as monotherapy and add-on pharmacological therapy for the treatment of T2DM. PMID: 31744308 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 19, 2019 Category: Drugs & Pharmacology Authors: Cowart K Tags: Ann Pharmacother Source Type: research

First Case of Azathioprine-Induced Severe Hematotoxicity in a Tunisian Patient With Homozygous TT for NUDT15 rs116855232.
PMID: 31744310 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - November 19, 2019 Category: Drugs & Pharmacology Authors: Ben Salem C, Hachana M, Fathallah N, Eya H, Ksiaa M Tags: Ann Pharmacother Source Type: research