Triptan use in elderly over 65 years and the risk of hospitalization for serious vascular events
ConclusionThe incidence of acute vascular events was low among triptan users. We found that triptan use among older may be associated with a low increased risk for acute vascular events, which may be more marked for cerebral events such as stroke, than for cardiac events. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 26, 2024 Category: Neurology Source Type: research
Is time really brain in stroke therapy?: A meta-analysis of mechanical thrombectomy up to 155 h post ictus
ConclusionOur meta-analysis provides evidence that supports the need of further randomized and prospective clinical trials to better assess the effectiveness and safety of MT in these patients. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 26, 2024 Category: Neurosurgery Source Type: research
Comparison of Incidence and Prognostic Impact of Ischemic Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry
CONCLUSIONS: Hospitalization for HF has become both the most frequent and one of the most ominous events among patients with chronic coronary syndrome. Although less frequent, major bleeding is strongly associated with worse patient survival. Secondary prevention should not be limited to preventing ischemic events. Minimizing bleeding and preventing HF may be at least as important.PMID:38660793 | DOI:10.1161/CIRCULATIONAHA.123.067938 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Gilles Lemesle Nicolas Lamblin Guillaume Schurtz Julien Labreuche Alain Duhamel Basile Verdier Philippe Gabriel Steg Christophe Bauters Source Type: research
Transportation Noise Pollution and Cardiovascular Health
Circ Res. 2024 Apr 26;134(9):1113-1135. doi: 10.1161/CIRCRESAHA.123.323584. Epub 2024 Apr 25.ABSTRACTEpidemiological studies have found that transportation noise increases the risk for cardiovascular morbidity and mortality, with solid evidence for ischemic heart disease, heart failure, and stroke. According to the World Health Organization, at least 1.6 million healthy life years are lost annually from traffic-related noise in Western Europe. Traffic noise at night causes fragmentation and shortening of sleep, elevation of stress hormone levels, and increased oxidative stress in the vasculature and the brain. These factor...
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Thomas M ünzel Michael Molitor Marin Kuntic Omar Hahad Martin R öösli Nicole Engelmann Mathias Basner Andreas Daiber Mette S ørensen Source Type: research
Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study
CONCLUSIONS: We successfully achieve molecular imaging of fibroblast activation in atherosclerotic lesions of rabbits, suggesting Al18F-NOTA-FAPI-04 PET/CT may be a potentially valuable tool to identify plaques.PMID:38664355 | DOI:10.1007/s11307-024-01919-9 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Tianxiong Ji Chunfang Zan Lina Li Jianbo Cao Yao Su Hongliang Wang Zhifang Wu Min-Fu Yang Kefei Dou Sijin Li Source Type: research
Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity
J Cereb Blood Flow Metab. 2024 Apr 25:271678X241248907. doi: 10.1177/0271678X241248907. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) disruption is increasingly recognized as an early contributor to the pathophysiology of cerebral ischemia/reperfusion (I/R) injury, and is also a key event in triggering secondary damage to the central nervous system. Recently, long non-coding RNA (lncRNA) have been found to be associated with ischemic stroke. However, the roles of lncRNA in BBB homeostasis remain largely unknown. Here, we report that long intergenic non-coding RNA-p21 (lincRNA-p21) was the most significantly down-...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Yun-Hua Zhao Yu Liang Kang-Ji Wang Sheng-Nan Jin Xiao-Meng Yu Qian Zhang Jia-Yi Wei Hui Liu Wen-Gang Fang Wei-Dong Zhao Yuan Li Yu-Hua Chen Source Type: research
Comparison of Incidence and Prognostic Impact of Ischemic Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry
CONCLUSIONS: Hospitalization for HF has become both the most frequent and one of the most ominous events among patients with chronic coronary syndrome. Although less frequent, major bleeding is strongly associated with worse patient survival. Secondary prevention should not be limited to preventing ischemic events. Minimizing bleeding and preventing HF may be at least as important.PMID:38660793 | DOI:10.1161/CIRCULATIONAHA.123.067938 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Gilles Lemesle Nicolas Lamblin Guillaume Schurtz Julien Labreuche Alain Duhamel Basile Verdier Philippe Gabriel Steg Christophe Bauters Source Type: research
Impact of ischemic stroke topography on early clinical outcome of basilar artery occlusion: a retrospective study
ConclusionUnfavorable early outcomes in patients with BAOS may be explained by a higher likelihood of inferior brain stem infarcts and lower rates of reperfusion success.Clinical relevance statementBasilar artery occlusion due to underlying stenosis is associated with a poorer prognosis than that caused by embolism; these results suggest that aggressive endovascular therapy, usually involving the placement of a permanent stent, may be warranted in these patients.Key PointsInferior brain stem and occipital infarcts are prognostically unfavorable in basilar artery occlusion.Basilar artery occlusion due to stenosis occurs mor...
Source: European Radiology - April 25, 2024 Category: Radiology Source Type: research
The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease
AbstractAnticoagulant therapy is a mainstay in the management of patients with cardiovascular disease and related conditions characterized by a heightened risk for thrombosis. Acute coronary syndrome, chronic coronary syndrome, ischemic stroke, and atrial fibrillation are the most common. In addition to their proclivity for thrombosis, each of these four conditions is also characterized by local and systemic inflammation, endothelial/endocardial injury and dysfunction, oxidative stress, impaired tissue-level reparative capabilities, and immune dysregulation that plays a critical role in linking molecular events, environmen...
Source: Journal of Thrombosis and Thrombolysis - April 25, 2024 Category: Hematology Source Type: research
Endovascular thrombectomy in wake-up stroke guided by arterial spin-labeling and fluid-attenuated inversion recovery versus diffusion-weighted imaging mismatch on MRI
ConclusionGuided by the ASL-DWI and FLAIR-DWI double mismatch, endovascular thrombectomy combined with standard medical treatment appears to yield superior functional outcomes in patients with WUS and large vessel occlusion compared to standard medical treatment alone. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - April 25, 2024 Category: Hematology Source Type: research
Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study
ConclusionsWe successfully achieve molecular imaging of fibroblast activation in atherosclerotic lesions of rabbits, suggesting Al18F-NOTA-FAPI-04 PET/CT may be a potentially valuable tool to identify plaques. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - April 25, 2024 Category: Molecular Biology Source Type: research
Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke
Nanomedicine, Ahead of Print. (Source: Future Medicine: Nanomedicine)
Source: Future Medicine: Nanomedicine - April 25, 2024 Category: Nanotechnology Authors: Gulrana Khuwaja Sivakumar S Moni Mohammad Firoz Alam Hafiz A Makeen Sarvat Zafar Mohammad Ashafaq Hasan Alhazmi Asim Najmi Shabihul Fatma Sayed Syed Mohammad Shakeel Iqubal Source Type: research
Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke
Nanomedicine, Ahead of Print. (Source: Nanomedicine)
Source: Nanomedicine - April 25, 2024 Category: Nanotechnology Authors: Gulrana Khuwaja Sivakumar S Moni Mohammad Firoz Alam Hafiz A Makeen Sarvat Zafar Mohammad Ashafaq Hasan Alhazmi Asim Najmi Shabihul Fatma Sayed Syed Mohammad Shakeel Iqubal Source Type: research
Stroke in Asia
Cerebrovasc Dis Extra. 2024 Apr 24. doi: 10.1159/000538928. Online ahead of print.ABSTRACTBackground There is a significant burden of stroke in Asia. Asia has the largest population in the world in 2023, estimated at 4.7 billion. Approximately 9.5-10.6 million strokes will be anticipated annually in the backdrop of a diverse group of well-developed and less developed countries with large disparities in stroke care resources. In addition, Asian countries are in varying phases of epidemiological transition. Summary In this review, we examined recent epidemiological features of ischaemic stroke and intracerebral haemorrhage i...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Kay Sin Tan Jeyaraj Durai Pandian Liping Liu Kazunori Toyoda Thomas Wai Hon Leung Shinichiro Uchiyama Sathoshi Kuroda Nijasri C Suwanwela Sanjith Aaron Hui Meng Chang Narayanaswamy Venketasubramanian Source Type: research
The Association of CHADS-P2A2RC Risk Score With Clinical Outcomes in Patients Taking P2Y12 Inhibitor Monotherapy After 3 Months of Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention
CONCLUSIONS: The CHADS-P2A2RC risk score is valuable in discriminating high-ischemic-risk patients. Even in such patients with a high risk of ischemic events, P2Y12 inhibitor monotherapy was associated with a lower incidence of bleeding without increased risk of ischemic events compared with prolonged DAPT.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02079194.PMID:38654565 | DOI:10.4070/kcj.2023.0268 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Pil Sang Song Seok-Woo Seong Ji-Yeon Kim Soo Yeon An Mi Joo Kim Kye Taek Ahn Seon-Ah Jin Jin-Ok Jeong Jeong Hoon Yang Joo-Yong Hahn Hyeon-Cheol Gwon Woo Jin Jang Hyuck Jun Yoon Jang-Whan Bae Woong Gil Choi Young Bin Song Source Type: research
