Comparison of Incidence and Prognostic Impact of Ischemic Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry
CONCLUSIONS: Hospitalization for HF has become both the most frequent and one of the most ominous events among patients with chronic coronary syndrome. Although less frequent, major bleeding is strongly associated with worse patient survival. Secondary prevention should not be limited to preventing ischemic events. Minimizing bleeding and preventing HF may be at least as important.PMID:38660793 | DOI:10.1161/CIRCULATIONAHA.123.067938 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Gilles Lemesle Nicolas Lamblin Guillaume Schurtz Julien Labreuche Alain Duhamel Basile Verdier Philippe Gabriel Steg Christophe Bauters Source Type: research
Impact of ischemic stroke topography on early clinical outcome of basilar artery occlusion: a retrospective study
ConclusionUnfavorable early outcomes in patients with BAOS may be explained by a higher likelihood of inferior brain stem infarcts and lower rates of reperfusion success.Clinical relevance statementBasilar artery occlusion due to underlying stenosis is associated with a poorer prognosis than that caused by embolism; these results suggest that aggressive endovascular therapy, usually involving the placement of a permanent stent, may be warranted in these patients.Key PointsInferior brain stem and occipital infarcts are prognostically unfavorable in basilar artery occlusion.Basilar artery occlusion due to stenosis occurs mor...
Source: European Radiology - April 25, 2024 Category: Radiology Source Type: research
The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease
AbstractAnticoagulant therapy is a mainstay in the management of patients with cardiovascular disease and related conditions characterized by a heightened risk for thrombosis. Acute coronary syndrome, chronic coronary syndrome, ischemic stroke, and atrial fibrillation are the most common. In addition to their proclivity for thrombosis, each of these four conditions is also characterized by local and systemic inflammation, endothelial/endocardial injury and dysfunction, oxidative stress, impaired tissue-level reparative capabilities, and immune dysregulation that plays a critical role in linking molecular events, environmen...
Source: Journal of Thrombosis and Thrombolysis - April 25, 2024 Category: Hematology Source Type: research
Endovascular thrombectomy in wake-up stroke guided by arterial spin-labeling and fluid-attenuated inversion recovery versus diffusion-weighted imaging mismatch on MRI
ConclusionGuided by the ASL-DWI and FLAIR-DWI double mismatch, endovascular thrombectomy combined with standard medical treatment appears to yield superior functional outcomes in patients with WUS and large vessel occlusion compared to standard medical treatment alone. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - April 25, 2024 Category: Hematology Source Type: research
Stroke in Asia
Cerebrovasc Dis Extra. 2024 Apr 24. doi: 10.1159/000538928. Online ahead of print.ABSTRACTBackground There is a significant burden of stroke in Asia. Asia has the largest population in the world in 2023, estimated at 4.7 billion. Approximately 9.5-10.6 million strokes will be anticipated annually in the backdrop of a diverse group of well-developed and less developed countries with large disparities in stroke care resources. In addition, Asian countries are in varying phases of epidemiological transition. Summary In this review, we examined recent epidemiological features of ischaemic stroke and intracerebral haemorrhage i...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Kay Sin Tan Jeyaraj Durai Pandian Liping Liu Kazunori Toyoda Thomas Wai Hon Leung Shinichiro Uchiyama Sathoshi Kuroda Nijasri C Suwanwela Sanjith Aaron Hui Meng Chang Narayanaswamy Venketasubramanian Source Type: research
The Association of CHADS-P2A2RC Risk Score With Clinical Outcomes in Patients Taking P2Y12 Inhibitor Monotherapy After 3 Months of Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention
CONCLUSIONS: The CHADS-P2A2RC risk score is valuable in discriminating high-ischemic-risk patients. Even in such patients with a high risk of ischemic events, P2Y12 inhibitor monotherapy was associated with a lower incidence of bleeding without increased risk of ischemic events compared with prolonged DAPT.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02079194.PMID:38654565 | DOI:10.4070/kcj.2023.0268 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Pil Sang Song Seok-Woo Seong Ji-Yeon Kim Soo Yeon An Mi Joo Kim Kye Taek Ahn Seon-Ah Jin Jin-Ok Jeong Jeong Hoon Yang Joo-Yong Hahn Hyeon-Cheol Gwon Woo Jin Jang Hyuck Jun Yoon Jang-Whan Bae Woong Gil Choi Young Bin Song Source Type: research
You only ECHO Twice
We report on an 80-year-old woman with a cerebral stroke. Successful thrombectomy revealed a histopathologically confirmed papillary fibroelastoma as the embolic source. Although it was not detectable on initial echocardiography, the tumour was discovered by transesophageal echocardiography. This case emphasises the importance of considering primary cardiac tumours as potential sources of emboli in ischaemic stroke. Keywords.PMID:38655734 (Source: Praxis)
Source: Praxis - April 24, 2024 Category: General Medicine Authors: Dominik Paugsch Margret Dabrowski Source Type: research
Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study
ConclusionNeuropsychiatric complications of COVID-19, especially AMS, were common, varied, and associated with in-hospital mortality in a diverse multicenter cohort at an epicenter of the COVID-19 pandemic. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Development and validation of a nomogram for predicting 28-day mortality in patients with ischemic stroke
ConclusionsUtilizing a comprehensive array of fourteen readily accessible variables, a prognostic nomogram was meticulously formulated and rigorously validated to provide precise prognostication of short-term mortality within the ischemic stroke cohort. (Source: PLoS One)
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Lingyan Fang Source Type: research
Endovascular thrombectomy for treatment of isolated posterior cerebral artery occlusion: a real-world analysis of hospitalizations in the United States
ConclusionRetrospective analysis of a large administrative registry in the Unites States demonstrates an association of EVT with favorable outcomes following IPCA occlusion, without concomitant risk of hemorrhagic transformation or mortality. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 24, 2024 Category: Neurosurgery Source Type: research
Regarding the predictor of perioperative stroke/TIA in carotid endarterectomy patients
We read Monaco's recent study1 with great interest. The authors assessed the relationship between thrombin receptor activator peptide 6 (TRAP), adenosine-5 ′-diphosphate (ADP), and arachidonic acid (ASPI) tests measured using multiple electrode aggregometry and the rate of stroke/transient ischemic attack (TIA) in patients undergoing carotid endarterectomy (CEA). They used a logistic LASSO regression model to identify factors independently associated with stroke/TIA. They concluded that an ADP>72 U and the need for a shunt during CEA were the only 2 variables independently associated with perioperative stroke/TIA. (Sourc...
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 24, 2024 Category: Anesthesiology Authors: Ying Zhang, Weiwei Chen Tags: Letter to the Editor Source Type: research
Outcomes of mechanical thrombectomy in patients with acute ischemic stroke and thrombocytopenia: systematic review and meta-analysis
ConclusionAs compared to patients without thrombocytopenia, thrombocytopenic AIS patients undergoing MT displayed lower functional independence and higher mortality rates, with no significant differences in sICH or successful recanalization. (Source: Journal of Neurology)
Source: Journal of Neurology - April 24, 2024 Category: Neurology Source Type: research
Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke
. (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - April 24, 2024 Category: Nutrition Authors: Cansu KocCigdem Inci AydemirBerna SalmanAysen CakirNursel Hasanoglu AkbulutPinar Levent KarabarutGonca TopalAycan Yigit CinarGokce TanerOzhan EyigorMehmet Canseva Department of Pharmacology, Faculty of Medicine, Bursa Uludag University, Bursa, T ürkiyeb Source Type: research
Development and Application of an Attribute-Based Taxonomy on the Benefits of Oral Anticoagulant Switching in Atrial Fibrillation: A Delphi Study
ConclusionsThe Delphi-based taxonomy identified five criteria for the beneficial effects of OAC switching, aiding in characterizing real-world OAC switching. (Source: Advances in Therapy)
Source: Advances in Therapy - April 24, 2024 Category: Drugs & Pharmacology Source Type: research
Relationship Between Hemorrhage Type and Development of Emotional and Behavioral Dyscontrol After Hemorrhagic Stroke
CONCLUSIONS: Patients with ICH and a low GCS score at admission are at increased risk of developing EBD 3 months after hemorrhagic stroke and may benefit from early intervention.PMID:38650464 | DOI:10.1176/appi.neuropsych.20230114 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - April 23, 2024 Category: Psychiatry Authors: Daniel Talmasov Sean Kelly Sarah Ecker Anlys Olivera Aaron Lord Lindsey Gurin Koto Ishida Kara Melmed Jose Torres Cen Zhang Jennifer Frontera Ariane Lewis Source Type: research
