Topography of Cholinergic Changes in Dementia With Lewy Bodies and Key Neural Network Hubs.
CONCLUSIONS: The topography of cholinergic vulnerability in DLB comprises key neural hubs involved in tonic alertness (cingulo-opercular), saliency (insula), visual attention (visual thalamus), and spatial navigation (fimbria/fornix) networks. The distinct denervation pattern suggests an important cholinergic role in specific clinical disease-defining features, such as cognitive fluctuations, visuoperceptual abnormalities causing visual hallucinations, visuospatial changes, and loss of balance caused by DLB. PMID: 32498602 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - June 7, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Bipolar Disorder Among Patients Diagnosed With Frontotemporal Dementia.
CONCLUSIONS: Manic or hypomanic episodes years before other symptoms of bvFTD may be a prodrome of this dementia, possibly indicating anterior temporal involvement in bvFTD. Other patients with late-onset bipolar disorder exhibit the nonprogressive frontotemporal dementia phenocopy syndrome. Finally, a few patients with bvFTD have a genetic predisposition for both disorders. PMID: 32498603 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - June 7, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Effect of Functional BDNF and COMT Polymorphisms on Symptoms and Regional Brain Volume in Frontotemporal Dementia and Corticobasal Syndrome.
Authors: Huey ED, Fremont R, Manoochehri M, Gazes Y, Lee S, Cosentino S, Tierney M, Wassermann EM, Momeni P, Grafman J Abstract OBJECTIVE: The authors examined the effects of two common functional polymorphisms-brain-derived neurotrophic factor (BDNF) Val66Met and catechol-O-methyltransferase (COMT) Val158Met-on cognitive, neuropsychiatric, and motor symptoms and MRI findings in persons with frontotemporal lobar degeneration (FTLD) syndromes. METHODS: The BDNF Val66Met and COMT Val158Met polymorphisms were genotyped in 174 participants with FTLD syndromes, including behavioral variant frontotemporal dementia, p...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Of Ghost Grandparents and Missing Limbs.
Authors: Restrepo-Martínez M PMID: 32397877 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Clinical Application of Findings From Longitudinal Studies of Younger-Onset Dementia: Rapid Review and Recommendations.
Authors: Loi SM, Goh AMY, Walterfang M, Velakoulis D Abstract Younger-onset dementia (YOD) presents with heterogeneous symptoms, has a variety of etiologies, and can be difficult to diagnose. The authors conducted a rapid review of longitudinal YOD cohorts and their related substudies to evaluate current literature that may inform the clinical information provided to patients about the progression and duration of illness and to highlight areas for future research. Searches were conducted using MEDLINE, CINAHL, PubMed, PsycINFO, and Web of Science for articles published between January 1966 and June 2018. Four longi...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Visual Hallucinations and the Role of Medications in Parkinson's Disease: Triggers, Pathophysiology, and Management.
Authors: Powell A, Ireland C, Lewis SJG Abstract Visual hallucinations, which are part of the syndrome of Parkinson's disease (PD) psychosis, affect patients' quality of life and increase the likelihood of residential aged-care placement. The association between visual hallucinations and dopaminergic and other medications that are necessary for the symptomatic management of motor and other symptoms of PD is a common clinical dilemma. While dopaminergic medications have long been associated with PD psychosis, a clear causal link has not been established, and other neurotransmitter systems, particularly noradrenaline...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 8, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Speech and Language Therapy for Voice Problems in Parkinson's Disease: A Meta-Analysis.
Authors: Xu H, Bao Z, Liang D, Li M, Wei M, Ge X, Liu J, Li J Abstract Patients with Parkinson's disease (PD) commonly have speech and voice problems that affect their functional communication and that are not sensitive to pharmacological or neurosurgical treatments. The authors aimed to evaluate the effects of speech and language therapies (SLTs) on dysphonia in patients with PD by analyzing data from published randomized controlled trials (RCTs). Studies in English and Chinese that were related to speech and language treatment for patients with PD were retrieved from PubMed, Embase, Chinese National Knowledge Inf...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 8, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Temporal Processing: Neural Correlates and Clinical Relevance.
Authors: Lad SS, Hurley RA, Taber KH PMID: 32279623 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - April 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Comparison of T1Rho MRI, Glucose Metabolism, and Amyloid Burden Across the Cognitive Spectrum: A Pilot Study.
CONCLUSIONS: Higher T1rho values were associated with greater cognitive impairment and pathological burden. T1rho, a biomarker that varies according to a feature common to each cascade rather than one that is unique to a particular pathology, has the potential to serve as a metric of neuropathology, theoretically providing a measure for assessing pathological status and for monitoring the neurodegeneration trajectory. PMID: 32283991 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - April 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Psychiatric Morbidity and Its Prognosis in Posterior Reversible Encephalopathy Syndrome.
Authors: Keynejad RC, David AS Abstract Posterior reversible encephalopathy syndrome (PRES) is a clinically and radiologically diagnosed disorder distinguished by subcortical vasogenic cerebral edema. To date, its presentation has been described through summarized neurological categories, such as seizures, headaches, "confusion," and "altered mental function." This retrospective case series identified all cases of clinically confirmed, radiologically diagnosed PRES resulting in treatment in a large teaching hospital from 2010 to 2019. The authors conducted a search for the term "reversible ...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - April 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Assessing Mental Health Difficulties of Persons With Huntington's Disease: Does Informant Presence Make a Difference?
CONCLUSIONS: Apathy may have been systemically underreported in participant-only interviews, which supports previous findings that persons with HD underreport mental health symptoms. When an informant was present, irritability scores were higher for both HD and non-HD individuals, suggesting that underreporting via self-report may be attributable to non-HD factors. Informant contributions to apathy assessments may be particularly important for persons with HD. Clinicians should note potential underreporting regarding irritability and affect, which was not remediated by informant presence. PMID: 32102601 [PubMed - as su...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 28, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Alcohol Use, Mental Health, and Functional Capacity as Predictors of Workplace Disability in a Cohort With Manifest Huntington's Disease.
CONCLUSIONS: These findings provide important new knowledge that can inform the development of strategies or targeted intervention trials to support persons with symptomatic HD to maintain their work roles. PMID: 32102602 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 28, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

On the Trail of White Matter.
Authors: Filley CM PMID: 32102603 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 28, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Patient Attribution of Posttraumatic Symptoms to Brain Injury Versus PTSD in Military-Related Mild TBI.
Authors: Hardy MS, Kennedy JE, Cooper DB Abstract OBJECTIVE: Persistent cognitive, somatic, and neuropsychiatric symptoms following mild traumatic brain injury (TBI) are influenced by posttraumatic stress disorder (PTSD), particularly in military patients. The authors evaluated the degree to which military service members with a history of mild TBI attributed posttraumatic symptoms to TBI versus PTSD. METHODS: Service members (N=372) with mild TBI were surveyed about the severity of posttraumatic symptoms across four symptom clusters (cognitive, affective, somatosensory, and vestibular) with the Neurobehavioral...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Examination of Potential Differences in Reporting of Sensitive Psychosocial Measures via Diagnostic Evaluation Using Computer Video Telehealth.
CONCLUSIONS: Veterans with PNES evaluated via telehealth did not appear to withhold sensitive or personal information compared with those evaluated in-clinic, suggesting that CVT may be a comparable alternative for conducting evaluations. Baseline evaluations are used to determine treatment suitability, and telehealth allows clinicians to gain access to important information that may improve or inform care. PMID: 32054400 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 15, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Functional Neurological (Conversion) Disorder: A Core Neuropsychiatric Disorder.
Authors: Perez DL, Aybek S, Nicholson TR, Kozlowska K, Arciniegas DB, LaFrance WC PMID: 31964243 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - January 24, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Baseline Cognitive Performance and Treatment Outcomes From Cognitive-Behavioral Therapies for Posttraumatic Stress Disorder: A Naturalistic Study.
CONCLUSIONS: These results discourage any notion of excluding patients with PTSD and poorer cognitive ability from CBTs. PMID: 31948321 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - January 19, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Anatomical Connectivity of the Visuospatial Attentional Network in Schizophrenia: A Diffusion Tensor Imaging Tractography Study.
CONCLUSIONS: This study is the first to describe the structural hemispheric lateralization and organization of the visuospatial attentional network in persons with schizophrenia. The main findings indicate loss of integrity in the SLF II, associated with loss of asymmetry in participants with schizophrenia, compared with healthy individuals, suggesting a potential substrate of attentional deficits. PMID: 31948322 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - January 19, 2020 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Evaluation of LiNES: A New Measure of Trauma, Negative Affect, and Relationship Insecurity Over the Life Span in Persons With FND.
CONCLUSIONS: This study provides further support for the links between FND and trauma, negative affect, and insecure attachment. Recognition of these factors is likely to be important for treatment and stratification of important subpopulations in research. These findings provide new insights into the association between the timing of negative experiences and their effect, with LiNES emerging as a potentially useful measure for patients presenting with FND. PMID: 31865870 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - December 25, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Outcome Measures for Functional Neurological Disorder: A Review of the Theoretical Complexities.
Authors: Nicholson TR, Carson A, Edwards MJ, Goldstein LH, Hallett M, Mildon B, Nielsen G, Nicholson C, Perez DL, Pick S, Stone J, and the FND-COM (Functional Neurological Disorders Core Outcome Measures) Group, FND-COM group collaborators are as follows Abstract The development and selection of optimal outcome measures is increasingly recognized as a key component of evidence-based medicine, particularly the need for the development of a standardized set of measures for use in clinical trials. This process is particularly complex for functional neurological disorder (FND) for several reasons. FND can present with ...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - December 25, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Anemia and Cognitive Performance in the ELSA-Brasil Cohort Baseline.
CONCLUSIONS: Anemia and hemoglobin levels were not associated with worse cognitive performance in this large cohort. PMID: 31795805 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - December 6, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Psychosis Remitted After Ependymoma Resection in a School-Aged Child.
Authors: Jules-Dole N, Uribe-Cardenas R, McReynolds LJ, Borden L, Chambers S, Bell WR, Ahn ES, Raabe E, Salpekar JA PMID: 31795806 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - December 6, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Functional Stroke Symptoms: A Narrative Review and Conceptual Model.
This article proposes a conceptual model of functional symptoms identified in stroke services and some hypotheses based on a narrative review of the functional neurological disorder literature. Predisposing factors may include illness experiences, stressors, and chronic autonomic nervous system arousal. Following the onset of distressing symptoms, perpetuating factors may include implicit cognitive processes, classical and operant conditioning, illness beliefs, and behavioral responses, which could form the basis of treatment targets. The proposed model will inform the development of theory-based interventions as well as a...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - November 16, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Panic Attack as the Sole Manifestation of Epilepsy Localized to the Nondominant Temporal Region.
Authors: Fraser-Rini J, Ochoa J PMID: 31726919 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - November 16, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Virtual Reality-Delivered Mirror Visual Feedback and Exposure Therapy for FND: A Midpoint Report of a Randomized Controlled Feasibility Study.
CONCLUSIONS: This study is the first to report on MVF and VR for treatment of FND. Results generated thus far support feasibility and justify continuation of the study and further investigation into the efficacy of VR interventions for FND. PMID: 31687867 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - November 8, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Vicarious Embarrassment or "Fremdscham": Overendorsement in Frontotemporal Dementia.
CONCLUSIONS: In the presence of social dysfunction and emotional blunting, these findings suggest that patients with bvFTD rely on their own perspective for a rule-based application of social norms in reporting vicarious embarrassment. The assessment of reports of embarrassment for others may indicate an early and previously unrecognized clinical measure for detecting bvFTD. PMID: 31687868 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - November 8, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

The Phenomenology of Acute Anosognosia for Hemiplegia.
CONCLUSIONS: These results highlight that heterogeneity, phenomenological complexity, and transience are hallmarks of AHP. This advances clinical AHP assessment by showing that assessment of performance, rather than just verbal response, uncovers multiple dimensions of AHP. Allochiria emerges as an anatomically distinct subcomponent of the disorder. These findings also have theoretical implications, because they do not lend support to unitary pathogenic models proposing that illusions of movement or impaired intention form the basis of AHP. Most patients rapidly improve, which should invigorate the search for typical compe...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Emotional Reactivity as a Vulnerability for Psychogenic Nonepileptic Seizures? Responses While Reliving Specific Emotions.
Authors: Roberts NA, Burleson MH, Torres DL, Parkhurst DK, Garrett R, Mitchell LB, Duncan CJ, Mintert M, Wang NC Abstract When asked to recall and describe memories evoking specific emotions, those with psychogenic nonepileptic seizures (PNES) experienced more difficulty than trauma controls; showed decreased (vs. increased) heart rate variability during happiness; and some experienced a PNES episode during shame. PMID: 31662092 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Leveraging the Shared Neurobiology of Placebo Effects and Functional Neurological Disorder: A Call for Research.
Authors: Burke MJ, Faria V, Cappon D, Pascual-Leone A, Kaptchuk TJ, Santarnecchi E PMID: 31662093 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Validation of the Delirium Diagnostic Tool-Provisional (DDT-Pro) With Medical Inpatients and Comparison With the Confusion Assessment Method Algorithm.
CONCLUSIONS: The DDT-Pro had high validity and reliability in provisional delirium diagnosis by physicians and nonexpert clinicians, although further validation is warranted before widespread use can be recommended. PMID: 31662094 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Associations of Race-Ethnicity and History of Traumatic Brain Injury With Age at Onset of Alzheimer's Disease.
This study examined whether a history of traumatic brain injury (TBI) is associated with age at onset of Alzheimer's disease (AD) in three racial-ethnic groups. METHODS: Data from 7,577 non-Hispanic Caucasian, 792 African American, and 870 Hispanic participants with clinically diagnosed AD were obtained from the National Alzheimer's Coordinating Center. Participants were categorized by the presence or absence of self-reported remote history of TBI (>1 year before diagnosis of AD) with loss of consciousness (LOC) (TBI+) or no history of TBI with LOC (TBI-). Any group differences in education; sex; APOE ε4 all...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 19, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

What Does Neuroscience Tell Us About the Conversion Model of Functional Neurological Disorders?
Authors: Cretton A, Brown RJ, LaFrance WC, Aybek S Abstract Is FND a mind or brain disorder? Both approaches are appropriate, because they examine the same entity from different angles, using different lenses and methods. To focus on one at the expense of the other is to lose sight of potential insights that each has to offer the other. PMID: 31619119 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 19, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Phenomenology and Management of Encephalitis.
Authors: Caroff SN PMID: 31613194 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 17, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Positron Emission Tomography: Updates on Imaging of Addiction.
Authors: Solingapuram Sai JKK, Hurley RA, Dodda M, Taber KH PMID: 31613195 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 17, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Wilder Penfield and the Architecture of Collaboration.
Authors: Schildkrout B, MacGillivray L, Lauterbach M PMID: 31613196 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 17, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Risk of Neuroleptic Malignant Syndrome in Encephalitides: Response to Caroff.
Authors: Sarkis RA PMID: 31613197 [PubMed - in process] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 17, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Clinical Correlates of Dream Enactment Behaviors in Previously Deployed OEF/OIF/OND Veterans: An Exploratory Analysis.
CONCLUSIONS: These results suggest that mTBI may disrupt neural circuits regulating sleep among OIF/OEF/OND veterans. Prospective, polysomnographic assessment of muscle tone and behavioral events during REM sleep is needed to characterize the physiology of DEBs in this population. PMID: 31587626 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 9, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

What Is the Role of a Specialist Assessment Clinic for FND? Lessons From Three National Referral Centers.
CONCLUSIONS: FND specialty clinics have an important role in ensuring correct diagnosis and appropriate treatment. Most patients with motor FND require specialized neurophysiotherapy. Patients readily accepted an integrated neuropsychiatric approach. Close collaboration between FND clinics and acute neurology facilities might improve early detection of FND and could improve outcomes. PMID: 31587627 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 9, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Impaired Action Control in Patients With Functional Movement Disorders.
CONCLUSIONS: These results suggest that two forms of inhibitory control, selective impulse inhibition and global action cancelation, are impaired in patients with FMD, independent of slowing on go reaction times. Improved understanding of action control in FMD may help in the development of new diagnostic and therapeutic strategies. PMID: 31587628 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 9, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Risk of Misdiagnosing Chronic Traumatic Encephalopathy in Men With Depression.
CONCLUSIONS: The clinical problems attributed to CTE, such as depression, suicidality, anxiety, anger control problems, and headaches, co-occurred in this sample of men with depression from the general population-illustrating that these problems are not specific or unique to CTE. More research is needed to determine whether depression is, in fact, a clinical subtype of CTE. PMID: 31587629 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 9, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Internal Versus External Frame of Reference in Functional Movement Disorders.
CONCLUSIONS: Patients with FMD exhibited high "within our control" internal general and health-specific frame of reference. LOC had no influence on quality of life or disease severity in this patient population. PMID: 31564234 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 1, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Delusions Without Hallucinations After Midbrain Infarction.
Authors: Sakamoto K, Yokoi K, Kawakatsu S, Kobayashi R, Kunihiro K, Okada O, Sato Y, Otani K, Hirayama K PMID: 31564235 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 1, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Outpatient Physical Therapy for Functional Neurological Disorder: A Preliminary Feasibility and Naturalistic Outcome Study in a U.S. Cohort.
CONCLUSIONS: This preliminary, retrospective cohort study demonstrated that treatment adherence to a U.S.-based outpatient physical therapy program was associated with clinical improvement. Prospective observational and randomized controlled trials are needed to further optimize physical therapy for patients with functional motor symptoms in the outpatient setting. PMID: 31564236 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - October 1, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Koro Delusion in Mild Cognitive Impairment Due to Alzheimer's Disease.
Authors: Tau M, Masurkar AV PMID: 31530117 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - September 20, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Serum and CSF Anti-NMDAR Antibody Testing in Psychiatry.
CONCLUSIONS: These findings suggest that traditional psychiatric care may be appropriate for patients with isolated psychiatric symptoms who have positive serum NMDAR testing when CSF is negative and there are no key clinical features such as cognitive deficits, catatonia, speech disturbance, and antipsychotic sensitivity. However, if these key features are present, a trial of immunomodulatory treatment should be considered with repeated examination of CSF for neuronal antibodies. PMID: 31530118 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - September 20, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Loss of Consciousness and Altered Mental State as Predictors of Functional Recovery Within 6 Months Following Mild Traumatic Brain Injury.
Authors: Roy D, Peters ME, Everett AD, Leoutsakos JS, Yan H, Rao V, T Bechtold K, Sair HI, Van Meter T, Falk H, Vassila A, Hall A, Ofoche U, Akbari F, Lyketsos C, Korley F Abstract OBJECTIVE: The authors tested the hypothesis that a combination of loss of consciousness (LOC) and altered mental state (AMS) predicts the highest risk of incomplete functional recovery within 6 months after mild traumatic brain injury (mTBI), compared with either condition alone, and that LOC alone is more strongly associated with incomplete recovery, compared with AMS alone. METHODS: Data were analyzed from 407 patients with mTBI f...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - September 20, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Predisposing Risk Factors for Functional Limb Weakness: A Case-Control Study.
Authors: Stone J, Warlow C, Deary I, Sharpe M Abstract OBJECTIVE: Functional limb weakness is a common symptom of functional neurological disorder. Few controlled studies have examined possible predisposing factors to determine their specificity for this symptom. METHODS: In this prospective case-control study, patients with functional limb weakness (
Source: Journal of Neuropsychiatry and Clinical Neurosciences - August 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

A Systematic Review of Neuropsychiatric Symptoms and Functional Capacity in Huntington's Disease.
CONCLUSIONS: There is some evidence that depression and apathy are associated with decreased functional capacity in Huntington's disease. Other neuropsychiatric symptoms have been infrequently examined. Further knowledge of the relationships between neuropsychiatric symptoms and functional capacity will identify areas for intervention and improvement of outcomes in patients with Huntington's disease. PMID: 31466515 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - August 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Motivational Interviewing Techniques to Improve Psychotherapy Adherence and Outcomes for Patients With Psychogenic Nonepileptic Seizures.
Authors: Tolchin B, Baslet G, Martino S, Suzuki J, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA Abstract Psychogenic nonepileptic seizures (PNES) are a highly disabling disorder frequently encountered by neurologists, psychiatrists, and emergency medicine physicians. There is accumulating evidence for the efficacy of psychological therapies, yet the majority of patients do not complete treatment. A range of health care system-based, clinician-based, and patient-based barriers to treatment exists, including stigma, poor clinician-patient communication, and patient ambivalence about the diagnosis and treatment of...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - August 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Functional Motor Symptoms in Parkinson's Disease and Functional Parkinsonism: A Systematic Review.
CONCLUSIONS: Findings suggest a possible relationship between PD and FP. Clinicians should keep in mind the possibility of functional symptoms in PD patients. PMID: 31466517 [PubMed - as supplied by publisher] (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - August 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research