Sexual Dimorphism in Brain Development: Influence on Affective Disorders
J Neuropsychiatry Clin Neurosci. 2021 Spring;33(2):A485-89. doi: 10.1176/appi.neuropsych.20100269.NO ABSTRACTPMID:34018811 | DOI:10.1176/appi.neuropsych.20100269 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 21, 2021 Category: Psychiatry Authors: Wilfredo L ópez-Ojeda Robin A Hurley Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Developing Precision Invasive Neuromodulation for Psychiatry
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20100268. doi: 10.1176/appi.neuropsych.20100268. Online ahead of print.ABSTRACTPsychiatric conditions are common and often disabling. Although great strides have been made in alleviating symptoms with pharmacotherapy and psychotherapeutic approaches, many patients continue to have severe disease burden despite the best therapies available. One of the pervasive challenges to improving treatment is that present diagnostic and therapeutic strategies lag behind our modern conceptualization of the pathophysiology of these disorders. Psychiatric symptoms manifest through...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Nicholas L Bormann Nicholas T Trapp Nandakumar S Narayanan Aaron D Boes Source Type: research

Insomnia Disorders: Nosology and Classification Past, Present, and Future
J Neuropsychiatry Clin Neurosci. 2021 May 14:appineuropsych20080206. doi: 10.1176/appi.neuropsych.20080206. Online ahead of print.ABSTRACTInsomnia is the most common sleep disorder in the adult population. However, the definition of insomnia disorder has varied across major classification systems and changed over time. In the present study, the investigators traced the evolution of insomnia disorder across classification systems, contemplated the empirical basis for its current definitions, and surveyed ongoing research efforts that may clarify insomnia nosology in the future. Three major classification systems for insomni...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 14, 2021 Category: Psychiatry Authors: Shi-Hui Poon Shin-Yi Quek Tih-Shih Lee Source Type: research

Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process
CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research

White Matter Disease and Psychiatric Dysfunction: Clinical and Neurobiological Insights
J Neuropsychiatry Clin Neurosci. 2021 May 6:appineuropsych21010018. doi: 10.1176/appi.neuropsych.21010018. Online ahead of print.NO ABSTRACTPMID:33951920 | DOI:10.1176/appi.neuropsych.21010018 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Christopher M Filley Source Type: research

Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process
CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research

White Matter Disease and Psychiatric Dysfunction: Clinical and Neurobiological Insights
J Neuropsychiatry Clin Neurosci. 2021 May 6:appineuropsych21010018. doi: 10.1176/appi.neuropsych.21010018. Online ahead of print.NO ABSTRACTPMID:33951920 | DOI:10.1176/appi.neuropsych.21010018 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Christopher M Filley Source Type: research

Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process
CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research

White Matter Disease and Psychiatric Dysfunction: Clinical and Neurobiological Insights
J Neuropsychiatry Clin Neurosci. 2021 May 6:appineuropsych21010018. doi: 10.1176/appi.neuropsych.21010018. Online ahead of print.NO ABSTRACTPMID:33951920 | DOI:10.1176/appi.neuropsych.21010018 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Christopher M Filley Source Type: research

Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process
CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research

White Matter Disease and Psychiatric Dysfunction: Clinical and Neurobiological Insights
J Neuropsychiatry Clin Neurosci. 2021 May 6:appineuropsych21010018. doi: 10.1176/appi.neuropsych.21010018. Online ahead of print.NO ABSTRACTPMID:33951920 | DOI:10.1176/appi.neuropsych.21010018 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Christopher M Filley Source Type: research

Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process
CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research

White Matter Disease and Psychiatric Dysfunction: Clinical and Neurobiological Insights
J Neuropsychiatry Clin Neurosci. 2021 May 6:appineuropsych21010018. doi: 10.1176/appi.neuropsych.21010018. Online ahead of print.NO ABSTRACTPMID:33951920 | DOI:10.1176/appi.neuropsych.21010018 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Christopher M Filley Source Type: research

Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process
CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research

White Matter Disease and Psychiatric Dysfunction: Clinical and Neurobiological Insights
J Neuropsychiatry Clin Neurosci. 2021 May 6:appineuropsych21010018. doi: 10.1176/appi.neuropsych.21010018. Online ahead of print.NO ABSTRACTPMID:33951920 | DOI:10.1176/appi.neuropsych.21010018 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Christopher M Filley Source Type: research

Etiologies of Delirium in Consecutive COVID-19 Inpatients and the Relationship Between Severity of Delirium and COVID-19 in a Prospective Study With Follow-Up
CONCLUSIONS: Among inpatients with COVID-19, at least three different etiological categories were identified for delirium. ICU staff treating patients with severe cases of COVID-19 should anticipate a greater severity of delirium. Although multivariate analyses with larger study samples are needed, more severe delirium may herald greater risk of death among COVID-19 patients.PMID:33843248 | DOI:10.1176/appi.neuropsych.20100251 (Source: Journal of Neuropsychiatry and Clinical Neurosciences)
Source: Journal of Neuropsychiatry and Clinical Neurosciences - April 12, 2021 Category: Psychiatry Authors: Juan D Vel ásquez-Tirado Paula T Trzepacz Jos é G Franco Source Type: research