Long-Term Alterations in Motor Skills, Neurogenesis and Astrocyte Numbers following Transient Cerebral Ischemia in Mice
Conclusions: Our current report demonstrates the long-term effects of transient cerebral ischemia on mice functional parameters and neurogenesis progression. Our data demonstrate that transient cerebral ischemia promotes a long-lasting regenerative response in the ipsilateral brain hemisphere, specifically in the neurogenic SVZ and DG regions.PMID:38674304 | PMC:PMC11052140 | DOI:10.3390/medicina60040658 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Vladimirs Pilipenko Jolanta Upite Beatrise Luize Revina Baiba Jansone Source Type: research
The role of ferroptosis as a regulator of oxidative stress in the pathogenesis of ischemic stroke
Cell death by ferroptosis results from disrupted iron metabolism, leading to redox-active Fenton reactions that generate lipid peroxidation. In ischemic stroke, where blood flow to the brain is limited, elevated iron absorption exacerbates oxidative stress, potentially inducing ferroptotic neuronal death. Studies demonstrate the involvement of ferroptosis in ischemic stroke, prompting exploration of ferroptosis-targeting therapies. Ferroptosis is a unique form of cell death that was first described in 2012 and plays a significant role in various diseases, including neurodegenerative conditions. It depends on a dysregulatio...
Source: FEBS Letters - April 27, 2024 Category: Biochemistry Authors: Susana Delgado ‐Martín,
Antonio Martínez‐Ruiz Tags: Review Source Type: research
Voacangine protects hippocampal neuronal cells against oxygen –glucose deprivation/reoxygenation‐caused oxidative stress and ferroptosis by activating the PI3K‐Akt‐FoxO signaling
In conclusion, voacangine protects hippocampal neuronal cells against OGD/R-caused oxidative stress and ferroptosis by activating the PI3K-Akt-FoxO signaling. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - April 27, 2024 Category: Toxicology Authors: Ying Li,
Yan Sun,
Jianghong Wang,
Xiaolong Wang,
Wenjie Yang Tags: RESEARCH ARTICLE Source Type: research
Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS
We examined associations between lipidomic profiles and incident ischemic stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids (n = 195) were measured from baseline blood samples, and lipids were consolidated into underlying factors using exploratory factor analysis. Cox proportional hazards models were used to test associations between lipid factors and incident stroke, linear regressions to determine associations betwee n dietary intake and lipid factors, and the inverse odds ratio weighting (IORW) approach to test mediation. The study followed participants over a medi...
Source: Translational Stroke Research - April 27, 2024 Category: Neurology Source Type: research
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Troms ø Study
CONCLUSION: The combination of obesity and ischemic stroke did not yield an excess risk of VTE. Our findings suggest that obese subjects with ischemic stroke do not have a more than additive risk of VTE.PMID:38665865 | PMC:PMC11043863 | DOI:10.1016/j.rpth.2024.102392 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 26, 2024 Category: Hematology Authors: Birgitte G T øndel Joakim K Sejrup V ânia M Morelli Maja-Lisa L øchen Inger Nj ølstad Ellisiv B Mathiesen Tom Wilsgaard John-Bjarne Hansen Sigrid K Br ækkan Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
Curr Issues Mol Biol. 2024 Apr 18;46(4):3484-3501. doi: 10.3390/cimb46040219.ABSTRACTIschemic stroke triggers a complex cascade of cellular and molecular events leading to neuronal damage and tissue injury. This review explores the potential therapeutic avenues targeting cellular signaling pathways implicated in stroke pathophysiology. Specifically, it focuses on the articles that highlight the roles of RhoA/ROCK and mTOR signaling pathways in ischemic brain injury and their therapeutic implications. The RhoA/ROCK pathway modulates various cellular processes, including cytoskeletal dynamics and inflammation, while mTOR sig...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Elena Anca Pino șanu Denisa P îrșcoveanu Carmen Valeria Albu Emilia Burada Andrei P îrvu Roxana Surugiu Raluca Elena Sandu Alina Florina Serb Source Type: research
Safety and efficacy of endovascular treatment for acute ischemic stroke of large-vessel occlusion beyond the time window based on imaging evaluation
CONCLUSIONS: The safety and effectiveness of EVT treatment for selected AIS-LVO patients with symptom onset of 24-72 h are not inferior to those treated within 6-24 h of onset, especially in a short term based on the pre-treatment advanced neuroimaging computed tomography perfusion even though further investigations are necessary to prove this finding.PMID:38665125 | DOI:10.1177/15910199241250081 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - April 26, 2024 Category: Radiology Authors: Shi-Dun Chen Cheng-Bao Yang Yong-Xiang Wang Yue-Han Yin Bu-Lang Gao Chun-Guang Chen Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
AZD1390, an ataxia telangiectasia mutated inhibitor, attenuates microglia-mediated neuroinflammation and ischemic brain injury
CONCLUSION: AZD1390 suppressed NF-κB signaling pathway to alleviate ischemic brain injury in experimental stroke, and attenuated microglia activation and neuroinflammation, which indicated that AZD1390 might be an attractive agent for the treatment of ischemic stroke.PMID:38668740 | PMC:PMC11048048 | DOI:10.1111/cns.14696 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 26, 2024 Category: Neuroscience Authors: Zhen Lan Long-Jie Qu Ying Liang Li-Qiu Chen Shuai Xu Jian-Wei Ge Zhi-Wei Xue Xin-Yu Bao Sheng-Nan Xia Hai-Yan Yang Jing Huang Yun Xu Xiao-Lei Zhu Source Type: research
Argon neuroprotection in ischemic stroke and its underlying mechanism
Brain Res Bull. 2024 Apr 24:110964. doi: 10.1016/j.brainresbull.2024.110964. Online ahead of print.ABSTRACTIschemic stroke (IS), primarily caused by cerebrovascular obstruction, results in severe neurological deficits and has emerged as a leading cause of death and disability worldwide. Recently, there has been increasing exploration of the neuroprotective properties of the inert gas argon. Argon has exhibited impressive neuroprotection in many in vivo and ex vivo experiments without signs of adverse effects, coupled with the advantages of being inexpensive and easily available. However, the efficient administration strate...
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Li Bao Yongxin Liu Qi Jia Sihao Chu Han Jiang Shuang He Source Type: research
Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment
CONCLUSION: EA ameliorates memory impairment in a rat model of ischemic stroke by reducing inflammation and ROS through the inhibition of P2X7R expression. In turn, this mechanism regulates Nrf2 and NLRP3 expression, suggesting EA is beneficial for ischemic stroke treatment using P2X7R as target.PMID:38670470 | DOI:10.1016/j.brainresbull.2024.110967 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Bingbing Lin Mengxue Wang Xiaocheng Chen Linsong Chai Jinglei Ni Jia Huang Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Troms ø Study
CONCLUSION: The combination of obesity and ischemic stroke did not yield an excess risk of VTE. Our findings suggest that obese subjects with ischemic stroke do not have a more than additive risk of VTE.PMID:38665865 | PMC:PMC11043863 | DOI:10.1016/j.rpth.2024.102392 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 26, 2024 Category: Hematology Authors: Birgitte G T øndel Joakim K Sejrup V ânia M Morelli Maja-Lisa L øchen Inger Nj ølstad Ellisiv B Mathiesen Tom Wilsgaard John-Bjarne Hansen Sigrid K Br ækkan Source Type: research
STZ-induced diabetes exacerbates neurons ferroptosis after ischemic stroke by upregulating LCN2 in neutrophils
This study aimed to investigate the effect of streptozotocin (STZ)-induced diabetes on ferroptosis after stroke from the immune cell perspective, and to provide a theoretical foundation for the clinical management of ischemic stroke in patients with diabetes. The results revealed that STZ-induced diabetes not only facilitates the infiltration of neutrophils into the brain after stroke, but also upregulates the expression of lipocalin 2 (LCN2) in neutrophils. LCN2 promotes lipid peroxide accumulation by increasing intracellular ferrous ions, which intensify ferroptosis in major brain cell populations, especially neurons. Ou...
Source: Experimental Neurology - April 26, 2024 Category: Neurology Authors: Huan Wang Zhao Wang Yuxiao Gao Jingjing Wang Yujia Yuan Cong Zhang Xiangjian Zhang Source Type: research
