AZD1390, an ataxia telangiectasia mutated inhibitor, attenuates microglia-mediated neuroinflammation and ischemic brain injury

CONCLUSION: AZD1390 suppressed NF-κB signaling pathway to alleviate ischemic brain injury in experimental stroke, and attenuated microglia activation and neuroinflammation, which indicated that AZD1390 might be an attractive agent for the treatment of ischemic stroke.PMID:38668740 | PMC:PMC11048048 | DOI:10.1111/cns.14696

Source: CNS Neuroscience and Therapeutics - April 26, 2024 Category: Neuroscience Authors: Zhen Lan Long-Jie Qu Ying Liang Li-Qiu Chen Shuai Xu Jian-Wei Ge Zhi-Wei Xue Xin-Yu Bao Sheng-Nan Xia Hai-Yan Yang Jing Huang Yun Xu Xiao-Lei Zhu Source Type: research