Is there a reliable brain morphological signature for migraine?
AbstractVoxel-based morphometry (VBM) is a popular non-invasive magnetic resonance imaging technique to investigate brain gray matter (GM) differences between groups. Recently, two VBM studies in migraine have been published in The Journal of Headache and Pain. Reviewing the two and those previous published VBM studies, we found considerable variations of the results. Spatially diverse brain regions with decreased and increased GM alterations and null findings have been reported. It is interesting to know whether there is a reliable brain morphological signature for migraine. Coordinate-based meta-analysis (CBMA) is increa...
Source: The Journal of Headache and Pain - July 11, 2020 Category: Neurology Source Type: research

Influence of headache pain intensity and frequency on migraine-related disability in chronic migraine patients treated with OnabotulinumtoxinA
ConclusionsHeadache pain intensity is as important as frequency when evaluating the clinical response and impact on patient headache-related disability after migraine preventive treatment with OnabotulinumtoxinA. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 11, 2020 Category: Neurology Source Type: research

Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion
ConclusionsReducing the level of NPFFR2 leads to the downregulation of capsaicin-induced CGRP in trigeminal ganglion, which would consequently attenuate the activation of trigeminovascular pathway. Thus, NPFFR2 could serve as a potential target for neuromodulation of cephalic pain. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 8, 2020 Category: Neurology Source Type: research

Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization
ConclusionsAcute but notchronic sleep deprivation enhances CSD susceptibility in rodents, possibly underlying its negative impact as a migraine trigger and exacerbating factor. Our findings underscore the importance of CSD as a therapeutic target in migraine  and suggest that headache management should identify and treat associated sleep disorders. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 6, 2020 Category: Neurology Source Type: research

Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis
ConclusionsThe administrative prevalence of migraine in this claims database suggests many patients with migraine did not seek medical care. Of those who did, fewer than one-third received preventive medication, with most patients having been prescribed only one such medication and few having continued treatment beyond 1  year. These outcomes suggest there is scope for improvement in migraine management in Germany. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 6, 2020 Category: Neurology Source Type: research

Erenumab in highly therapy-refractory migraine patients: First German real-world evidence
ConclusionsErenumab seems to be a promising therapeutic option in highly therapy-refractory migraine patients.Trial registrationRetrospective registered. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 3, 2020 Category: Neurology Source Type: research

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals
ConclusionsP2X7 receptors expressed on glutamatergic nerve terminals in the rat TCN can mediate Glu release directly and indirectly by facilitating the activation of presynaptic AMPA receptors. The high level of glial ATP that occurs during chronic pain states can promote widespread release of Glu as well as can increase the function of AMPA receptors. In this manner, ATP contributes to the AMPA receptor activation involved in the onset and maintenance of the central sensitization associated with chronic pain. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 2, 2020 Category: Neurology Source Type: research

Pitfals in recognition and management of trigeminal neuralgia
ConclusionWhile TN has typical features and it is well defined by the available international diagnostic criteria, it is still frequently misdiagnosed and mistreated. There is a need to improve the neurological knowledge in order to promptly recognize the clinical picture of TN and properly adhere to the specific guidelines. This may result in a favorable outcome for patients, whose quality of life is usually severely impaired. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 30, 2020 Category: Neurology Source Type: research

Migraine start, course and features over the cycle of combined hormonal contraceptive users with menstrual migraine – temporal relation to bleeding and hormone withdrawal: a prospective diary-based study
ConclusionThe day of hormone-withdrawal migraine and the first bleeding day are highly predictable in CHC users. Migraine onset is mostly day − 1 and 1 of the bleeding and on days 1–4 of the hormone-free interval. Migraine attacks of CHC users in the hormone-free interval are severe and long lasting. Further trials are necessary to investigate if this knowledge can be used to optimise prevention. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 24, 2020 Category: Neurology Source Type: research

Impact of primary headache disorder on quality of life among school students in Kuwait
ConclusionPrimary headache disorder can have a significant impact on the quality of life in children. It can affect their engagement in activities and academic achievement. Implementing strategies to properly manage schoolchildren with primary headaches can have profound effects on their quality of life. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 24, 2020 Category: Neurology Source Type: research

Effect of age on pharmacokinetics, efficacy, and safety of galcanezumab treatment in adult patients with migraine: results from six phase 2 and phase 3 randomized clinical trials
ConclusionsAge (up to 65  years) does not affect efficacy in migraine prevention and has no clinically meaningful influence on galcanezumab PK to warrant dose adjustment. Furthermore, older galcanezumab-treated patients experienced no increases in frequency of AEs or increases in blood pressure compared with age-matched p lacebo-treated patients.Trial registrationsEVOLVE-1 (NCT02614183, registered 23 November 2015), EVOLVE-2 (NCT02614196, 23 November 2015), REGAIN (NCT02614261, 23 November 2015), ART-01 (NCT01625988, 20 June 2012, ), I5Q-MC-CGAB (NCT02163993, 12 June 2014, ), I5Q-MC-CGAJ (NCT02614287, 23 November 20...
Source: The Journal of Headache and Pain - June 23, 2020 Category: Neurology Source Type: research

The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies
AbstractChronic pain surrounding the temporomandibular joints and masticatory muscles is often the primary chief complaint of patients with temporomandibular disorders (TMD) seeking treatment. Yet, the neuro-pathophysiological basis underlying it remains to be clarified. Neuroimaging techniques have provided a deeper understanding of what happens to brain structure and function in TMD patients with chronic pain. Therefore, we performed a systematic review of magnetic resonance imaging (MRI) studies investigating structural and functional brain alterations in TMD patients to further unravel the neurobiological underpinnings...
Source: The Journal of Headache and Pain - June 19, 2020 Category: Neurology Source Type: research

Addressing chronic persistent headaches after MTBI as a neuropathic pain state
AbstractAn increasing number of patients with chronic persistent post-traumatic headache (PPTH) after mild traumatic brain injury (MTBI) are being referred to headache or pain specialists as conventional treatment options for primary headache disorders have not been able to adequately alleviate their debilitating headache symptoms. Evolving clinical and mechanistic evidences support the notation that chronic persistent MTBI related headaches (MTBI-HA) carry the hallmark characteristics of neuropathic pain. Thus, in addition to conventional treatment options applicable to non-traumatic primary headache disorders, other avai...
Source: The Journal of Headache and Pain - June 19, 2020 Category: Neurology Source Type: research

European headache federation consensus on the definition of resistant and refractory migraine
ConclusionsWe hope, that the updated EHF definition will be able to solve the conflicts that have limited the use of definitions which have been put forward in the past. Only with a widely accepted definition, progresses in difficult-to-treat migraine can be achieved. This new definition has also the aim to increase the understanding of the impact of the migraine as a disease with all of its social, legal and healthcare implications. It is the hope of the EHF Expert Consensus Group that the proposed criteria will stimulate further clinical, scientific and social attention to patients who suffer from migraine which is diffi...
Source: The Journal of Headache and Pain - June 16, 2020 Category: Neurology Source Type: research

Validation of an algorithm for automated classification of migraine and tension-type headache attacks in an electronic headache diary
ConclusionsThe substantial level of agreement indicates that the classification tool is a valuable instrument for automated evaluation of electronic headache diaries, which can thereby support the diagnostic and therapeutic clinical processes. Based on this study ’s results, additional diagnostic functionalities of primary headache management apps can be implemented. Finally, future research can use this classification algorithm for large scale database analysis for epidemiological studies. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 12, 2020 Category: Neurology Source Type: research

Lasmiditan mechanism of action – review of a selective 5-HT 1F agonist
AbstractMigraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this neurological disease led to the discovery that calcitonin gene-related peptide (CGRP) is a key neuropeptide involved in pain signaling during a migraine attack. CGRP-mediated neuronal sensitization and glutamate-based second- and third-order neuronal signaling may be an important component involved in migraine pain. The activation of several serotonergic receptor subtypes can block the release of CGRP, other neuropeptides, and neurotransmitters, and can relieve the symptoms o...
Source: The Journal of Headache and Pain - June 10, 2020 Category: Neurology Source Type: research

The prevalence of headache disorders in children and adolescents in Lithuania: a schools-based study
ConclusionsFindings were not very different from those reported in Turkey and Austria, but with more TTH. Headache has, therefore, again been shown to be common in children and adolescents, and UdH confirmed as a headache type that must be recognised and included in accounts of headache in these age groups. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 10, 2020 Category: Neurology Source Type: research

Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine
ConclusionsThese data demonstrates the possibility of sensitization of vestibular nucleus neurons to impair vestibular function after CM, and anti-CGRP treatment to restore vestibular dysfunction in patients with CM. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 10, 2020 Category: Neurology Source Type: research

Low-value care practice in headache: a Spanish mixed  methods research study
ConclusionsThis study identified low-value headache practices that need to be eradicated and provided data on their frequency and cost overruns. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 10, 2020 Category: Neurology Source Type: research

Sentinel headache as a warning symptom of ischemic stroke
AbstractBackgroundThere are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors as compared to a simultaneous control group.MethodsEligible patients (n = 550) had first-ever acute ischemic stroke with presence of new infarction onmagnetic resonance imaging with diffusion-weighted imaging (n = 469) or on computed tomography (n = 81). As a control group we studied in parallel patients (n = 192) who were admitted to the emergen...
Source: The Journal of Headache and Pain - June 10, 2020 Category: Neurology Source Type: research

Multidimensional assessment of the effects of erenumab in chronic migraine patients with previous unsuccessful preventive treatments: a comprehensive real-world experience
AbstractBackgrounderenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report the clinical experience from an Italian real-world setting using erenumab in patients with chronic migraine experiencing previous unsuccessful preventive treatments.MethodsSeventy patients with chronic migraine and failure to ≥4 migraine preventive medication classes initially received monthly erenumab 70 mg s.c. Patients without a clinically meaningful improvement, considered as a >  30% reduction in headache days per month, after &...
Source: The Journal of Headache and Pain - June 9, 2020 Category: Neurology Source Type: research

Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia
ConclusionThe significant impact of migraine on work productivity and regular activity, appears to lead to substantial monetary loss attributed to not only absenteeism, but more importantly to presenteeism. This study also highlights the unmet needs in migraine management among employees in the banking sector. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 8, 2020 Category: Neurology Source Type: research

The fifth cranial nerve in headaches
AbstractThe fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache patholo...
Source: The Journal of Headache and Pain - June 5, 2020 Category: Neurology Source Type: research

Short-term efficacy and safety of lasmiditan, a novel 5-HT 1F receptor agonist, for the acute treatment of migraine: a systematic review and meta-analysis
ConclusionsThis meta-analysis suggests that lasmiditan is effective for the acute treatment of migraine with a higher incidence of CNS-related adverse reactions compared with placebo. Long-term, open-label, multi-dose trials are required to verify the current findings. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 5, 2020 Category: Neurology Source Type: research

High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Tr øndelag health surveys 2006–2008 and 2017–2019
AbstractBackgroundSeveral previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investigate the influence of hs-CRP at baseline on the risk of developing migraine 11  years later.MethodsData from the Nord-Tr øndelag Health Study performed in 2006–2008 (baseline) and 2017–2019 were used. A total of 19,574 participants without migraine at baseline were divided into three groups based on hs-CRP levels (
Source: The Journal of Headache and Pain - June 5, 2020 Category: Neurology Source Type: research

Genetics of migraine aura: an update
AbstractMigraine is a common brain disorder with a large genetic component. Of the two main migraine types, migraine with aura and migraine without aura, the genetic underpinning in the former is least understood. Given the evidence from epidemiological studies in cohorts and families that the genetic contribution is highest in migraine with aura, this seems paradoxical. Various genetic approaches have been applied to identify genetic factors that confer risk for migraine. Initially, so-called candidate gene associations studies (CGAS) have been performed that test DNA variants in genes prioritized based on presumed a prio...
Source: The Journal of Headache and Pain - June 5, 2020 Category: Neurology Source Type: research

On the utility of the trail making test in migraine with and without aura: a meta-analysis
This study demonstrates the sensit ivity of the TMT in detecting cognitive alterations in migraine. This test should be considered for inclusion in cognitive batteries assessing patients with migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 3, 2020 Category: Neurology Source Type: research

Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study
ConclusionsAmong patients with persistent PTH, erenumab resulted in a lower frequency of moderate to severe headache days in this 12-week open-label trial. In addition, erenumab was well-tolerated as discontinuations due to adverse events were low. Placebo-controlled randomized clinical trials are needed to adequately evaluate the efficacy and safety of erenumab in patients with  persistent PTH.Trial registrationClinicalTrials.Gov,NCT03974360. Registered on April 17, 2019 - Retrospectively registered (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 3, 2020 Category: Neurology Source Type: research

The applicability of web-based solutions in headache epidemiology research
ConclusionOnline headache epidemiology research could be a resource saving alternative to person-to-person studies, however, further research is needed to overcome the problems related to methods of sampling, access and engagement. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 1, 2020 Category: Neurology Source Type: research

A prospective real-world analysis of erenumab in refractory chronic migraine
AbstractBackgroundClinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab in a real-world setting in patients with refractory CM.MethodsThis is a prospective single centre real-world audit conducted in patients with CM with and without medication overuse, refractory to established preventive medications, who received monthly erenumab for 6 months.ResultsOf 164 patients treated, 162 patients (female  = 135, mean age 46 ± 14.3 years o...
Source: The Journal of Headache and Pain - June 1, 2020 Category: Neurology Source Type: research

The impact of remission and coexisting migraine on anxiety and depression in cluster headache
AbstractBackgroundOur aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission.MethodsWe analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of ≥10 at baseline (during a cluster bout). We assessed for changes in ...
Source: The Journal of Headache and Pain - May 29, 2020 Category: Neurology Source Type: research

Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging
ConclusionsMigraine pathophysiology is associated with microstructural abnormalities within the trigeminal nerve that are consistent with histological evidence of altered myelin and/or organization. These peripheral nerve changes may provide further insight into migraine pathophysiology and enable a greater understanding for targeted treatments of pain alleviation. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 29, 2020 Category: Neurology Source Type: research

Volume of the rectus capitis posterior minor muscle in migraine patients: a cross-sectional structural MRI study
ConclusionsWe found no difference in RCPmi volume between migraine patients and controls, suggesting no structural RCPmi pathology in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 27, 2020 Category: Neurology Source Type: research

Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence
ConclusionNotwithstanding some phenotypic similarities, persistent post-traumatic headache after traumatic brain injury, is considered a separate phenomenon from migraine but available data is inconclusive. High-quality studies are further required to investigate the pathophysiological mechanisms of this secondary headache, in order to identify new targets for treatment and to prevent disability. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 24, 2020 Category: Neurology Source Type: research

Subdiagnosis, but not presence of vestibular symptoms, predicts balance impairment in migraine patients – a cross sectional study
ConclusionsThe subdiagnosis of migraine, instead of the presence of vestibular symptoms, can predict postural control impairments observed in migraineurs. This lends support to the notion that balance instability is related to the presence of aura and migraine chronicity, and that it should be considered even in patients without vestibular symptoms. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 24, 2020 Category: Neurology Source Type: research

Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study
ConclusionsPregabalin prescriptions for pain disorders were limited to short-term use, which is consistent around the world. However, the average prescribed dose in Taiwan was lower than those in Western countries, and was frequently below the recommended ranges. Potential causes included the duration of natural history of PHN, and off-label prescriptions for pain in acute herpes zoster, rather than PHN, as well as intolerance to the side effects. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 19, 2020 Category: Neurology Source Type: research

Pain rates in general population for the period 1991 –2015 and 10-years prediction: results from a multi-continent age-period-cohort analysis
ConclusionsProjected increase in pain rates will require specific interventions by health and welfare systems, as pain is responsible for limited quality of subjective well-being, reduced employment rates and hampered work performance. Worksite and lifestyle interventions will therefore be needed to limit the impact of projected higher pain rates. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 13, 2020 Category: Neurology Source Type: research

Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database
ConclusionAmong migraine patients in China, NSAIDs were commonly prescribed as acute medication, while utilization of migraine-specific triptans and preventive medications was low. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 13, 2020 Category: Neurology Source Type: research

13th European Headache Federation Congress 2019: Meeting Abstracts - part 2
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 12, 2020 Category: Neurology Source Type: research

Use of outpatient medical care by headache patients in Germany: a population-based cross-sectional study
AbstractBackgroundHeadache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study are (1) to assess self-reported headache-specific physician consultations and (2) to identify headache-related and sociodemographic predictors.MethodsData of a random sample of the general population in Germany aged ≥14 years were analyzed (N = 2461). A multivariate binary logistic regression was conducted to identify a parsimonious model to predict physician consultation.Res...
Source: The Journal of Headache and Pain - May 11, 2020 Category: Neurology Source Type: research

Jealousy in women with migraine: a cross-sectional case-control study
AbstractBackgroundEstrogen influences susceptibility to migraine attacks and it has been suggested to affect jealousy in romantic relationships in women. Therefore, we hypothesized that migraine women may be more jealous.MethodsJealousy levels and hormonal status were determined based on a cross-sectional, web-based, questionnaire study among female migraine patients and controls. A random sample of participants was selected from a validated migraine database. Participants with a serious and intimate monogamous relationship were included (n = 498) and divided into the following subgroups: menstrual migraine (...
Source: The Journal of Headache and Pain - May 11, 2020 Category: Neurology Source Type: research

Lost productivity associated with headache and depression: a quality improvement project identifying a patient population at risk
ConclusionsThis quality improvement project identified a practice gap for treatment of comorbid depression in patients presenting to Neurology for headache. Depression strongly correlated with productivity loss, highlighting a possible target for the economic burden of headache. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 11, 2020 Category: Neurology Source Type: research

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura
ConclusionIn patients with migraineurs without aura, the functional connectivities between the sensorimotor brain areas and other brain regions was reduced. These disrupted functional connectivities might contribute to abnormalities in visual processing, multisensory integration, nociception processing, spatial attention and intention and dysfunction in cognitive evaluation and modulation of pain. Recurrent headache attacks might lead to the disrupted network between primary motor cortex and temporal regions and between primary somatosensory cortex and temporal regions. Pain sensitivity and patient quality of life are clos...
Source: The Journal of Headache and Pain - May 6, 2020 Category: Neurology Source Type: research

Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study
ConclusionsWe found a significantly increased risk of tinnitus within 1 year of trigeminal neuralgia diagnosis compared to those without the diagnosis. Further studies in other countries and ethnicities are needed to explore the relationship between trigeminal neuralgia and subsequent tinnitus. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 6, 2020 Category: Neurology Source Type: research

Sensory processing patterns affect headache severity among adolescents with migraine
ConclusionsSensory processing difficulties are common among adolescents with episodic migraine. Sensory avoidance may be related to pain experience, and pain catastrophizing and disability level.Trial registrationISRCTNISRCTN73824458. Registered 28 September 2014. retrospectively registered. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 6, 2020 Category: Neurology Source Type: research

Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database
ConclusionsOur results showed that 39.5% of respondents developed pain over a five-year follow-up period, that there are proximal and distal risk factors for pain, and that part of them are directly modifiable. Actions aimed at improving sleep, reducing weight among obese people and treating fatigue would positively impact on pain onset, and avoiding vigorous exercise should be advised to people aged 60 or over, in particular if female or obese. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 6, 2020 Category: Neurology Source Type: research

Direct and indirect costs of cluster headache: a prospective analysis in a tertiary level headache centre
AbstractBackgroundCluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy and prophylactic treatment. The few data available on the economic burden of CH come from retrospective studies based on questionnaires, population surveys and medical insurance claims database. Although all these studies showed an important economic burden, they provided different estimates depending on variability of CH awareness and management, healthcare systems, available therapies and use of tr...
Source: The Journal of Headache and Pain - May 4, 2020 Category: Neurology Source Type: research

A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication
AbstractBackgroundMigraine is a chronic, disabling neurological disease characterized by moderate-to-severe headache pain with other symptoms, including nausea, vomiting, and photophobia. Triptans, while generally effective, are insufficiently efficacious in 30 –40% of patients and poorly tolerated by or contraindicated in others. We assessed the impact of insufficient response to triptans on health-related quality of life (HRQoL) and work productivity in patients currently receiving any prescribed triptan formulation as their only acute migraine medicat ion.MethodsData were from the 2017 Adelphi Migraine Disease Spe...
Source: The Journal of Headache and Pain - April 29, 2020 Category: Neurology Source Type: research

From transformation to chronification of migraine: pathophysiological and clinical aspects
AbstractChronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8  days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from differen t perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiolo...
Source: The Journal of Headache and Pain - April 29, 2020 Category: Neurology Source Type: research

Brain morphologic abnormalities in migraine patients: an observational study
ConclusionOur findings could provide a approach to understand possible differences in the pathogenesis of two type of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 25, 2020 Category: Neurology Source Type: research