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Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review
ConclusionWe found that there is a lack of high-quality evidence-based studies on the pharmacological treatment of PTH. Future studies are highly needed and must emphasize open-label studies with rigorous methodology or RCTs with a placebo-controlled design. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 21, 2019 Category: Neurology Source Type: research

Differences in treatment response between migraine with aura and migraine without aura: lessons from clinical practice and RCTs
AbstractMigraine is a major public health problem afflicting approximately 10% of the general population and is a leading cause of disability worldwide, yet our understanding of the basis mechanisms of migraine remains incomplete. About a third of migraine patients have attacks with aura, consisting of transient neurological symptoms that precede or accompany headache, or occur without headache. For patients, aura symptoms are alarming and may be transiently disabling. For clinicians and scientists, aura represents an intriguing neurophysiological event that may provide important insight into basic mechanisms of migraine. ...
Source: The Journal of Headache and Pain - September 6, 2019 Category: Neurology Source Type: research

Identifying menstrual migraine – improving the diagnostic criteria using a statistical method
ConclusionsWhile the ICHD$$\frac {2}{3}$$-criterion is a simple screening tool for menstrual migraine, the sMM provides a more specific diagnosis and can be applied irrespective of the number of menstrual cycles recorded. It is particularly useful for clinical trials of menstrual migraine where a chance association between migraine and menstruation must be excluded. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 6, 2019 Category: Neurology Source Type: research

New diagnostic criteria for headache attributed to transient ischemic attacks
ConclusionsExisting diagnostic criteria for headache attributed to TIA of the International Classification of Headache Disorders are too insensitive. We suggest new diagnostic criteria with high sensitivity and preserved specificity. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 6, 2019 Category: Neurology Source Type: research

Aura and Head pain: relationship and gaps in the translational models
AbstractMigraine is a complex brain disorder and initiating events for acute attacks still remain unclear. It seems difficult to explain the development of migraine headache with one mechanism and/or a single anatomical location. Cortical spreading depression (CSD) is recognized as the biological substrate of migraine aura and experimental animal studies have provided mechanisms that possibly link CSD to the activation of trigeminal neurons mediating lateralized head pain. However, some CSD features do not match the clinical features of migraine headache and there are gaps in translating CSD to migraine with aura. Clinical...
Source: The Journal of Headache and Pain - September 3, 2019 Category: Neurology Source Type: research

Structural changes of cerebellum and brainstem in migraine without aura
ConclusionMWoAs exhibited microstructural changes in the cerebellum and the local brainstem. These structural differences might contribute to dysfunction of the transmission and modulation of noxious information, trigeminal nociception, and conduction and integration of multimodal information in MWoAs. These findings further suggest involvement of the cerebellum and the brainstem in the pathology of migraine without aura. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 2, 2019 Category: Neurology Source Type: research

Current and emerging evidence-based treatment options in chronic migraine: a narrative review
ConclusionsTreatment of chronic migraine is a dynamic and rapidly advancing area of research. New developments in this field have the potential to improve the diagnosis and provide more individualised treatments for this condition. Establishing a culture of prevention is essential for reducing the personal, social and economic burden of chronic migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 30, 2019 Category: Neurology Source Type: research

Animal models of migraine and experimental techniques used to examine trigeminal sensory processing
ConclusionSeveral well validated animal models of pain relevant for headache exist, the researcher should consider the advantages and limitations of each model before selecting the most appropriate to answer the specific research question. Further, we should continually strive to refine existing and generate new animal and non-animal models that have the ability to advance our understanding of head pain as well as non-pain symptoms of primary headache disorders. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 29, 2019 Category: Neurology Source Type: research

Lasmiditan for acute treatment of migraine in patients with cardiovascular risk factors: post-hoc analysis of pooled results from 2 randomized, double-blind, placebo-controlled, phase 3 trials
ConclusionsWhen analyzed by the presence of CVRFs, there was no statistical difference in lasmiditan efficacy or the frequency of likely CV TEAEs. Despite the analysis being limited by a single-migraine-attack design, the lack of differences in efficacy and safety with increasing numbers of CVRFs indicates that lasmiditan might be considered in the treatment algorithm for patients with CVRFs. Future studies are needed to assess long-term efficacy and safety.Trial registrationClinicalTrials.govNCT02439320 (SAMURAI), registered 18 March 2015 andClinicalTrials.govNCT02605174 (SPARTAN), registered 11 November 2015. (Source: Th...
Source: The Journal of Headache and Pain - August 29, 2019 Category: Neurology Source Type: research

Identifying and managing refractory migraine: barriers and opportunities?
This article reviews the published criteria and proposes a new set of criteria. The epidemiology, pathophysiology and management options are also reviewed. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 23, 2019 Category: Neurology Source Type: research

Migraine patients ’ journey until a tertiary headache center: an observational study
ConclusionsBrazilian patients with migraine experiment a long journey until getting to a headache specialist and are submitted to a great number of unnecessary exams, especially those with chronic migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 15, 2019 Category: Neurology Source Type: research

Electrical stimulation of the superior sagittal sinus suppresses A-type K + currents and increases P/Q- and T-type Ca 2+ currents in rat trigeminal ganglion neurons
ConclusionThese results suggest that ES decreases theIA in small-sized TG neurons and increases P/Q- and T-type Ca2+ currents in the IB4− subpopulation of TG neurons, which might contribute to neuronal hyperexcitability in a rat model of ES-induced migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 2, 2019 Category: Neurology Source Type: research

Shortcomings and missed potentials in the management of migraine patients - experiences from a specialized tertiary care center
ConclusionsOur data suggest, that many migraine patients to this day do not receive state-of-the-art therapy. Adherence to national and international European guidelines could improve the outcome in migraine patients. Future research should try to answer why guidelines are not followed. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 1, 2019 Category: Neurology Source Type: research

Migraine: a major debilitating chronic non-communicable disease in Brazil, evidence from two national surveys
ConclusionOn this evidence, migraine should be included in the next health surveys in Brazil. Public-health policy should recognize the burden of migraine expressed in public ill health, and promote health services offering better diagnosis and treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 1, 2019 Category: Neurology Source Type: research

Efficacy and safety of lasmiditan in patients using concomitant migraine preventive medications: findings from SAMURAI and SPARTAN, two randomized phase 3 trials
AbstractObjectiveTo study the efficacy and safety of lasmiditan for acute treatment of migraine in patients using migraine preventive medications.BackgroundWhile lasmiditan has been proven to be an effective acute treatment for migraine, its effectiveness has not been examined when used concurrently with migraine preventives.MethodsSAMURAI and SPARTAN were similarly designed, double-blind, phase 3, placebo-controlled studies of patients 18  years or older with 3 to 8 migraine attacks per month. Patients were randomized to treat a migraine attack with oral lasmiditan 50 mg (SPARTAN only), 100 mg, 200&th...
Source: The Journal of Headache and Pain - July 24, 2019 Category: Neurology Source Type: research

Remote electrical neuromodulation (REN) in the acute treatment of migraine: a comparison with usual care and acute migraine medications
AbstractBackgroundThere is a significant unmet need for new, effective and well tolerated acute migraine treatments. A recent study has demonstrated that a novel remote electrical neuromodulation (REN) treatment provides superior clinically meaningful pain relief with a low rate of device-related adverse events. The results reported herein compare the efficacy of REN with current standard of care in the acute treatments of migraine.MethodsWe performed a post-hoc analysis on a subgroup of participants with migraine from a randomized, double-blind, parallel-group, sham-controlled, multicenter study on acute care. The origina...
Source: The Journal of Headache and Pain - July 22, 2019 Category: Neurology Source Type: research

The association between headache and low back pain: a systematic review
ConclusionsWe identified a positive association between persistent LBP and primary headache disorders. The quality of the review findings is limited by diversity of populations, study designs and uncertainly about headache and LBP definitions.Trial registrationPROSPERO 2018CRD42018086557. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 15, 2019 Category: Neurology Source Type: research

Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study
This study reviewed the medical records of adults with inadequately controlled CM from 7 private neurology practices in Australia who, beginning in March 2014, received PBS-subsidized onabotulinumtoxinA per product labelling for the first time. The primary effectiveness measure was the percentage of patients achieving a response defined by 50% or greater reduction in headache days from baseline after 2 treatment cycles. Additional data were recorded in the case report form when available and included demographics, clinical characteristics, headache severity and frequency, Headache Impact Test (HIT-6) score, medication use,...
Source: The Journal of Headache and Pain - July 15, 2019 Category: Neurology Source Type: research

New daily persistent headache: a systematic review on an enigmatic disorder
ConclusionNDPH remains poorly understood but very burdensome for the individual. Multi-center randomized controlled trials are recommended to gain better understanding of NDPH and to establish evidence based treatments. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 15, 2019 Category: Neurology Source Type: research

Genetic mouse models of migraine
AbstractMouse models of rare monogenic forms of migraine provide a unique experimental system to study the cellular and circuit mechanisms of the primary brain dysfunctions causing a migraine disorder. Here, we discuss the migraine-relevant phenotypes and the migraine-relevant functional alterations in the brain of five genetic mouse models of migraine, four of which carry mutations derived from patients with familial hemiplegic migraine (FHM) and the fifth carry a mutation from patients with both phenotypically normal MA and familial advanced sleep phase syndrome (FASPS). We focus on the latter mouse model, in which a ubi...
Source: The Journal of Headache and Pain - July 12, 2019 Category: Neurology Source Type: research

Diffusion tensor imaging in middle-aged headache sufferers in the general population: a cross-sectional population-based imaging study in the Nord-Tr øndelag health study (HUNT-MRI)
ConclusionMiddle-age onset headache may be related to a widespread process in the white matter leading to altered microstructure. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 10, 2019 Category: Neurology Source Type: research

Fluctuations of sensorimotor processing in migraine: a controlled longitudinal study of beta event related desynchronization
ConclusionIncreased preictal baseline beta activity may reflect a decrease in pre-activation in the sensorimotor cortex. Altered pre-activation may lead to changes in thresholds for inhibitory responses and increased beta-ERD response, possibly reflecting a generally increased preictal cortical responsivity in migraine. Cyclic fluctuations in the activity of second- and third-order afferent somatosensory neurons, and their associated cortical and/or thalamic interneurons, may accordingly also be a central part of the migraine pathophysiology. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 9, 2019 Category: Neurology Source Type: research

Emerging evidence of occipital nerve compression in unremitting head and neck pain
AbstractUnremitting head and neck pain (UHNP) is a commonly encountered phenomenon in Headache Medicine and may be seen in the setting of many well-defined headache types. The prevalence of UHNP is not clear, and establishing the presence of UHNP may require careful questioning at repeated patient visits. The cause of UHNP in some patients may be compression of the lesser and greater occipital nerves by the posterior cervical muscles and their fascial attachments at the occipital ridge with subsequent local perineural inflammation. The resulting pain is typically in the sub-occipital and occipital location, and, via anatom...
Source: The Journal of Headache and Pain - July 2, 2019 Category: Neurology Source Type: research

Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & amp; EVOLVE-2)
AbstractBackgroundPatients with high-frequency episodic migraine (HFEM) have a greater disease burden than those with low-frequency episodic migraine (LFEM). Acute treatment overuse increases the risk of migraine chronification in patients with HFEM. Galcanezumab, a humanized monoclonal antibody binding calcitonin gene-related peptide (CGRP), is effective for migraine prevention with a favorable safety profile. Here, we investigate whether there are differences in galcanezumab efficacy in patients with LFEM or with HFEM.MethodsData were pooled from two double-blind, placebo-controlled phase 3 trials; EVOLVE-1 and EVOLVE-2....
Source: The Journal of Headache and Pain - June 28, 2019 Category: Neurology Source Type: research

A real-world study on unmet medical needs in triptan-treated migraine: prevalence, preventive therapies and triptan use modification from a large Italian population along two years
ConclusionsThis real-life analysis underlined that the unmet medical needs concern a large part of patients treated with triptans and there is an undertreatment with preventive therapies whose benefit is insufficient, which may be due to the lack of effective preventive strategies, probably still reserved to severe patients. This study allows forecasting the actual impact of newest therapeutic strategies aimed to fill this gap. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 27, 2019 Category: Neurology Source Type: research

Quality assurance in specialized headache units in Spain: an observational prospective study
ConclusionAlthough there is variability among Specialized Headache Units, the overall quality was generally better than in traditional neurology consultations in Spain. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 25, 2019 Category: Neurology Source Type: research

Advances in genetics of migraine
ConclusionsThe complexity of migraine disorders is mirrored by their genetic complexity. A comprehensive knowledge of the genetic factors underpinning migraine will lead to improved understanding of molecular mechanisms and pathogenesis, to enable better diagnosis and treatments for migraine sufferers. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 21, 2019 Category: Neurology Source Type: research

Correction to: Primary headaches during lifespan
Following publication of the original article [1], we have been notified that one of the author names was incompletely presented. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 19, 2019 Category: Neurology Source Type: research

The HUNT4 study: the validity of questionnaire-based diagnoses
ConclusionThe HUNT4 questionnaire is a valid tool for identifying persons with lifetime migraine, self-reported active migraine and active migraine applying liberal modified criteria. The agreement for TTH was fair. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 13, 2019 Category: Neurology Source Type: research

Trigeminal autonomic cephalalgias presenting in a multidisciplinary tertiary orofacial pain clinic
ConclusionThis study demonstrates the importance of a multidisciplinary approach to diagnosing complex orofacial pain patients and the importance of awareness of primary headache disorders, in particular trigeminal autonomic cephalalgias, thereby reducing unnecessary diagnostic delays or procedures. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 11, 2019 Category: Neurology Source Type: research

Real-world treatment patterns and patient-reported outcomes in episodic and chronic migraine in Japan: analysis of data from the Adelphi migraine disease specific programme
We report patient demographics, prescribed treatment, work productivity, and quality-of-life data for people with CM ( ≥15 headache days/month) or EM (not fulfilling CM criteria). In descriptive analyses, continuous and categorical measures were assessed using t-tests and Chi-squared tests, respectively.ResultsPhysicians provided data for 977 patients (mean age 44.5  years; 77.2% female; 94.5% with EM, 5.5% with CM). A total of 634/977 (64.9%) invited patients (600 with EM; 34 with CM) also provided data. Acute therapy was currently being prescribed in 93.7% and 100% of patients with EM and CM, respectively (p&nb...
Source: The Journal of Headache and Pain - June 7, 2019 Category: Neurology Source Type: research

Letter to the editor: European headache federation guidelines on the use of monoclonal antibodies acting on the calcitonin gene-related peptide or its receptor for migraine prevention
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 4, 2019 Category: Neurology Source Type: research

Erenumab and galcanezumab in chronic migraine prevention: effects after treatment termination
In this study we assessed the effects of discontinuation of preventive erenumab and galcanezumab treatment in patients with chronic migraine.MethodsThis retrospective pooled analysis included completers of the open-label extension study phase for the preventive treatment of chronic migraine with galcanezumab (NCT02614261; 9  months) and erenumab (NCT02174861; 12 months) in a single headache center. We compare migraine data until week 12 after open-label treatment completion, when patients did not have any pharmacological preventive medication, to study baseline values of the double-blind trial period, and to ...
Source: The Journal of Headache and Pain - June 3, 2019 Category: Neurology Source Type: research

Burden and costs of migraine in a Swedish defined patient population – a questionnaire-based study
The objective of this study is to map the health-economic consequences of migraine in a defined patient population in terms of healthcare consumption, production loss and QoL in Sweden.MethodsThe study is based on data from a web-based survey to members in the Swedish patients ’ association suffering from migraine. The survey was conducted in May 2018 and included people with migraine aged 18 years or older. The survey included questions on health resource consumption, lost production resulting from migraine-related absenteeism and presenteeism, and QoL as measured by the EuroQol 5 dimensions questionnaire (EQ...
Source: The Journal of Headache and Pain - May 31, 2019 Category: Neurology Source Type: research

Clinical features of visual migraine aura: a systematic review
ConclusionsWe created a comprehensive list of VAS types reported by migraine patients based on all currently available data from clinical studies, which can be used for testing and validation in future studies. We propose that, based on this work, an official list of VAS types should be developed, preferably within the context of the International Classification of Headache Disorders of the International Headache Society. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 30, 2019 Category: Neurology Source Type: research

Aura and Stroke: relationship and what we have learnt from preclinical models
ConclusionPreclinical models suggest a key role for enhanced SD susceptibility and microembolization to explain both the occurrence of migraine attacks and the increased stroke risk in migraineurs. Therapeutic targeting of SD and microembolic events, or potential causes thereof, will be promising for treatment of aura and may also prevent ischemic infarction in vulnerable brains. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 29, 2019 Category: Neurology Source Type: research

Correction to: Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study
After publication of the original article [1], the authors have notified us that an updated version of Figures 1, 2 and 3 should have been published. The incorrect and revised figures can be found below. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 28, 2019 Category: Neurology Source Type: research

Migraine and cluster headache show impaired neurosteroids patterns
ConclusionWe have shown for the first time that large and disease-specific changes in circulating neurosteroid levels are associated with chronic headache disorders, raising the interesting possibility that fluctuations of neurosteroids at their site of action might shape the natural course of migraine and cluster headache. Whether the observed changes in neurosteroids are genetically determined or rather result from exposure to environmental or intrinsic stressors is unknown. This might also be matter for further investigation because stress is a known triggering factor for headache attacks in both migraineurs and cluster...
Source: The Journal of Headache and Pain - May 27, 2019 Category: Neurology Source Type: research

Correction to: European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention
AbstractFollowing publication of the original article [1], the authors notified us of some misreported data due to the publication of the EVOLVE-2 trial (Cephalalgia. 2018;38:1442 –1454), which substantially changed the level of evidence of galcanezumab for the prevention of episodic migraine. All changes are marked in bold and with red in Figure 1 and Figure 2. Please note that the final recommendations remain unchanged. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 23, 2019 Category: Neurology Source Type: research

The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension
ConclusionThe findings support the hypothesis that the elevation of intracranial pressure induces a microstructural compression of the optic nerve impairing axoplasmic flow and thereby causing the prelaminar papilledema. The microstructural compression of the optic nerve as well as the clinical symptoms improve within hours of normalization of intracranial pressure. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 23, 2019 Category: Neurology Source Type: research

Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 23, 2019 Category: Neurology Source Type: research

Aids to management of headache disorders in primary care (2nd edition)
AbstractTheAids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the European Headache Federation, they update the first edition published 11 years ago.The common headache disorders (migraine, tension-type headache and medication-overuse headache) are major causes of ill health. They should be managed in primary care, firstly because their management is generally not difficult, and secondly because they are so common. TheseAids to Management, with theEuropean principles of ma...
Source: The Journal of Headache and Pain - May 21, 2019 Category: Neurology Source Type: research

Optimising migraine treatment: from drug-drug interactions to personalized medicine
AbstractMigraine is the most disabling and expensive chronic disorders, the etiology of which is still not fully known. The neuronal systems, (glutammatergic, dopaminergic, serotoninergic and GABA-ergic) whose functionality is partly attributable to genetically determined factors, has been suggested to play an important role. The treatment of acute attacks and the prophylactic management of chronic forms include the use of different category of drugs, and it is demonstrated that not each subject has the same clinical answer to them. The reason of this is to be searched in different functional capacity and quantity of phase...
Source: The Journal of Headache and Pain - May 17, 2019 Category: Neurology Source Type: research

Correction to: Therapeutic novelties in migraine: new drugs, new hope?
After publication of the original article 1, the authors have notified us that the row corresponding to the “Alniditan” drug shouldn’t have been included in Table 1. Table 1 should therefore be presented as below: (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 17, 2019 Category: Neurology Source Type: research

The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse
ConclusionThe acute treatment of migraine will certainly improve with the advent of two novel classes of drugs, i.e., the 5-HT1F receptor agonists (lasmiditan) and the small molecule CGRP receptor antagonists (gepants). Data on the effects of 5-HT1F receptor agonism in relation to MOH, as well as the effects of chronic CGRP receptor blockade, are awaited with interest. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 16, 2019 Category: Neurology Source Type: research

Hypoechogenicity of brainstem raphe correlates with depression in migraine patients
This study was to investigate the possible role of BR examination via TCS in migraineurs with depression.MethodsForty two migraine without aura (MwoA) patients and 40 healthy controls were recruited. Echogenicity of lentiform nuclei (LN), caudate nuclei (CN), substantia nigra (SN) and brainstem raphe (BR) and width of the frontal horns of the lateral ventricles and the third ventricle were assessed with TCS. The diagnosis of depression was based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders IV (DSM –IV), and the severity of depression was measured by Hamilton Rating Scale for Depression...
Source: The Journal of Headache and Pain - May 15, 2019 Category: Neurology Source Type: research

The changing faces of migraine
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 10, 2019 Category: Neurology Source Type: research

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications
ConclusionsThe available data highlight the need for a comprehensive evaluation of psychiatric disorders in migraine in order to promote an integrated model of care and carefully address the burden and psychosocial impairment related to psychiatric comorbidities in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 9, 2019 Category: Neurology Source Type: research

Physician and patient preferences for dosing options in migraine prevention
This study evaluated the impact of having flexible dosing options on acceptance of and adherence to a new migraine preventive therapy class among adults with migraine.MethodsIn this observational study, two 20-min online surveys were completed: one by physicians currently treating adult patients with migraine and the other by adults with migraine. Both surveys presented the participants with three scenarios: 1) only monthly, 2) only quarterly, and 3) both dosing options of the new medication are available. Physicians estimated the proportion of their migraine patients who would receive the new medication in each scenario. ...
Source: The Journal of Headache and Pain - May 9, 2019 Category: Neurology Source Type: research

How to integrate monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor in daily clinical practice
ConclusionsSpecificity, long half-life, efficacy, tolerability, and ease of use make monoclonal antibodies targeting the calcitonin gene-related peptide or its receptor an appealing treatment option for migraine prevention. Optimal strategies to manage treatment over time still need to be clarified with real-life data. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 6, 2019 Category: Neurology Source Type: research