CACNA1A-p.Thr501Met mutation associated with familial hemiplegic migraine: a family report
We report the clinical characteristics and genetic analysis of 12 patients belonging to a family withCACNA1A-p.Thr501Met gene mutation.MethodsWe screened for mutations inCACNA1A gene 15 patients belonging to the same family. The exonic sequences ofCACNA1A were analyzed using a Tru-seq ® Custom Amplicon (TSCA) (Illumina Inc., San Diego, CA) targeted capture and paired end library kit. Sanger sequencing was used to confirmCACNA1A variants and segregation analysis.ResultsCACNA1A-p.Thr501Met mutation was found in 12 of the 15 patients screened, which was compatible with the diagnosis of FHM1.Attacks of hemiplegic migraine ...
Source: The Journal of Headache and Pain - July 28, 2021 Category: Neurology Source Type: research

Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model
ConclusionsOur findings demonstrate that repeated intranasal OT eliminates central sensitization by regulating synaptic plasticity via OTR in CM. The effect of OT has closely associated with the down-regulation of AC1/PKA/pCREB signaling pathway, which is activated in CM model. Repeated intranasal OT may be a potential candidate for CM prevention. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 27, 2021 Category: Neurology Source Type: research

Psychiatric and cognitive comorbidities of persistent post-traumatic headache attributed to mild traumatic brain injury
AbstractObjectiveTo investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI).MethodsA total of 100 patients with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls free of mild TBI were enrolled between July 2018 and June 2019. Quality of sleep was evaluated using the Pittsburgh Sleep Quality Index, while symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Cognitive impairment was evaluated using the Montreal Cognitive Assessment questi...
Source: The Journal of Headache and Pain - July 26, 2021 Category: Neurology Source Type: research

Reduction in acute migraine-specific and non-specific medication use in patients treated with erenumab: post-hoc analyses of episodic and chronic migraine clinical trials
ConclusionsIn both EM and CM, treatment with erenumab is associated with a significant and sustained reduction in the use of acute headache medication, in particular MSM.Trial registrationsNCT02456740; NCT02066415; NCT02174861. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 23, 2021 Category: Neurology Source Type: research

Altered speech patterns in subjects with post-traumatic headache due to mild traumatic brain injury
ConclusionsCompared to HC, subjects with acute PTH demonstrate altered speech as measured by objective features of speech production. For individuals with PTH, speech production may have been more effortful resulting in slower speaking rates and more precise vowel articulation during headache vs. when they were headache-free, suggesting that speech alterations were related to PTH and not solely due to the underlying mTBI. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 23, 2021 Category: Neurology Source Type: research

Early alterations of cortical thickness and gyrification in migraine without aura: a retrospective MRI study in pediatric patients
ConclusionsDifferences in CT and LGI in patients affected by migraine without aura may suggest the presence of congenital and acquired abnormalities in migraine and that migraine might represent a vast spectrum of different entities. In particular, ≥ 12-year-old pediatric patients showed a decreased CT in areas related to the executive function and nociceptive networks compared to younger patients, while female patients compared to males showed a decreased CT of the auditory cortex compared to males. Therefore, early and tailored therapies are paramount to obtain migraine control, prevent cerebral reduction of co...
Source: The Journal of Headache and Pain - July 22, 2021 Category: Neurology Source Type: research

Mild traumatic brain injury affects the features of migraine
AbstractBackgroundHeadache is one of the most common symptoms after concussion, and mild traumatic brain injury (mTBI) is a risk factor for chronic migraine (CM). However, there remains a paucity of data regarding the impact of mTBI on migraine-related symptoms and clinical course.MethodsOf 2161 migraine patients who participated in the American Registry for Migraine Research between February 2016 and March 2020, 1098 completed questions assessing history of TBI (50.8%). Forty-four patients reported a history of moderate to severe TBI, 413 patients reported a history of mTBI. Patients ’ demographics, headache symptom...
Source: The Journal of Headache and Pain - July 22, 2021 Category: Neurology Source Type: research

Structured Q1 headache services as the solution to the ill-health burden of headache: 1. Rationale and description
AbstractIn countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropriate: most headache disorders can effectively and more efficiently (and at lower cost) be treated in educationally supported primary care. At the same time, compartmentalizing divisions between primary, secondary and tertiary care in many health-care systems create multiple inefficiencies, confronting patients attempting to navigate these levels (the “patient journey”) with perplexing obstacles.High demand for headache care, estimated here in a needs-asses...
Source: The Journal of Headache and Pain - July 21, 2021 Category: Neurology Source Type: research

The chronobiology of migraine: a systematic review
ConclusionsThe findings of the current review suggest a possible role of chronobiologic rhythms to the periodicity of migraine attacks. Future studies are, however, still needed to provide more knowledge of the oscillating nature of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 19, 2021 Category: Neurology Source Type: research

Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine
ConclusionOur study showed that sensory hypersensitivities commonly occur and overlap in patients with migraine and that multiple sensory hypersensitivity symptoms have a significant impact on headache-related disability. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 19, 2021 Category: Neurology Source Type: research

Cortical metabolic and structural differences in patients with chronic migraine. An exploratory 18FDG-PET and MRI study
ConclusionsCM patients showed frontotemporal hypometabolism and increased frontal cortical thickness when compared to HC that may explain some cognitive and behavioural pain-processing and sensory integration alterations in CM patients. Combined information from sequential or simultaneous PET and MRI could optimize the study of complex functional neurological disorders such as migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 17, 2021 Category: Neurology Source Type: research

MAB-MIG: registry of the spanish neurological society of erenumab for migraine prevention
We present their first results.MethodsPatients fulfilled the ICHD-3 criteria for migraine and had  ≥ 4 MMDs. Sociodemographic and clinical data were registered as well as MMDs, monthly headache days, MHDs, prior and concomitant preventive treatment, medication overuse headache (MOH), migraine evolution, adverse events, and patient-reported outcomes (PROs): headache impact test (HIT-6), mig raine disability assessment questionnaire (MIDAS), and patient global improvement change (PGIC). A >  50% reduction of MMDs after 12 weeks was considered as a response.ResultsWe included 210 patient...
Source: The Journal of Headache and Pain - July 17, 2021 Category: Neurology Source Type: research

The relationship between headache-attributed disability and lost productivity: 1. A review of the literature
ConclusionsThe literature is silent on the relationship between headache-attributed disability and lost productivity. In view of its health economic and political importance, empirical studies are required to remedy this. A prerequisite is to clarify what is meant by “disability” in this context. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 17, 2021 Category: Neurology Source Type: research

Comorbidities of primary headache disorders: a literature review with meta-analysis
ConclusionsSome of the most relevant comorbidities of primary headache disorders – back pain, anxiety and depression, diabetes, ischemic heart disease and stroke – are among the most burdensome conditions, together with headache themselves, according to the GBD study. A joint treatment of headaches and of these comorbidities may positively impact on headache sufferers’ hea lth status and contribute to reduce the impact of a group of highly burdensome diseases. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 14, 2021 Category: Neurology Source Type: research

Assessment of normalized cerebral blood flow and its connectivity with migraines without aura during interictal periods by arterial spin labeling
ConclusionsOur results indicate that migraine patients exhibit abnormalities in regional CBF and feature CBF connection defects at the resting state. The affected areas involve information perception, information integration, and emotional, pain and visual processing. Our findings might provide important clues for the pathophysiology of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 14, 2021 Category: Neurology Source Type: research

Interleukin-6 induces spatially dependent whole-body hypersensitivity in rats: implications for extracephalic hypersensitivity in migraine
ConclusionsHere we show that while stimulation of upper body regions with IL-6 including the meninges and brainstem can cause widespread hypersensitivity spreading to the paws, similar stimulation of the lower body does not cause the spread of hypersensitivity into the head. These data are consistent with the observations that whole body hypersensitivity is specific to conditions such as migraine where pain is present in the head and they may provide insight into co-morbid pain states associated with migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 13, 2021 Category: Neurology Source Type: research

High concurrent validity between digital and analogue algometers to measure pressure pain thresholds in healthy participants and people with migraine: a cross-sectional study
AbstractBackgroundPressure pain thresholds (PPTs) are commonly assessed to quantify mechanical sensitivity in various conditions, including migraine. Digital and analogue algometers are used, but the concurrent validity between these algometers is unknown. Therefore, we assessed the concurrent validity between a digital and analogue algometer to determine PPTs in healthy participants and people with migraine.MethodsTwenty-six healthy participants and twenty-nine people with migraine participated in the study. PPTs were measured interictally and bilaterally at the cephalic region (temporal muscle, C1 paraspinal muscles, and...
Source: The Journal of Headache and Pain - July 12, 2021 Category: Neurology Source Type: research

Efficacy and safety of fremanezumab in patients with episodic and chronic migraine with documented inadequate response to 2 to 4 classes of migraine preventive medications over 6  months of treatment in the phase 3b FOCUS study
In this study, we evaluated the long-term efficacy, safety, and tolerability of monthly and quarterly fremanezumab.MethodsEpisodic migraine and chronic migraine patients completing the 12-week double-blind period of the FOCUS trial entered the 12-week open-label extension and received 3 monthly doses of fremanezumab (225  mg). Changes from baseline in monthly migraine days, monthly headache days of at least moderate severity, days of acute headache medication use, days with photophobia/phonophobia, days with nausea or vomiting, disability scores, and proportion of patients achieving a ≥50% or  ≥7...
Source: The Journal of Headache and Pain - July 10, 2021 Category: Neurology Source Type: research

The patients ’ perspective on the burden of idiopathic intracranial hypertension
ConclusionsIn addition to headaches and visual disturbances, sleep disturbances and depression are frequent symptoms in IIH and contribute to the patients ’ burden. Structured questionnaires can help to identify IIH patients’ needs and can lead to personalized and better treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 8, 2021 Category: Neurology Source Type: research

Phenome-wide analysis highlights putative causal relationships between self-reported migraine and other complex traits
ConclusionsOverall, our results suggest a potential vascular component to migraine, highlighting the role of vasoconstriction and platelet clumping. Stressful life events and occupational variables potentially influence a higher migraine risk. Additionally, a migraine could impact the psychological well-being of individuals. Our findings provide novel testable hypotheses for future studies that may inform the design of new interventions to prevent or reduce migraine risk and recurrence. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 8, 2021 Category: Neurology Source Type: research

Age-related differences in resting state functional connectivity in pediatric migraine
ConclusionsWe demonstrate that brain alterations begin early in youth with migraine and are modulated by development. This highlights the need for further study into the neural mechanisms of migraine in youth specifically, to aid in the development of more effective treatments. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 6, 2021 Category: Neurology Source Type: research

Correction to: Medication overuse and drug addiction: a narrative review from addiction perspective
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 5, 2021 Category: Neurology Source Type: research

A universal outcome measure for headache treatments, care-delivery systems and economic analysis
ConclusionsThe new outcome measure expressed in intuitive units of time is applicable to treatments of all modalities and to system-level interventions for multiple headache types, with utility for CEA and for informing health policy. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - July 1, 2021 Category: Neurology Source Type: research

CGRP induces migraine-like symptoms in mice during both the active and inactive phases
ConclusionsA decrease in wheel activity is an additional clinically relevant phenotype observed in this model, which is reminiscent of the reduction in normal physical activity observed in migraine patients. The ability of peripheral CGRP to induce migraine-like symptoms in mice is independent of the phase of the circadian cycle. Therefore, preclinical assessment of migraine-like phenotypes can likely be done during the more convenient inactive phase of mice. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 30, 2021 Category: Neurology Source Type: research

Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study
ConclusionsChronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Migraine may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 29, 2021 Category: Neurology Source Type: research

Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period
AbstractBackgroundAltered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to decrease the expression of pituitary adenylate cyclase-activating polypeptide 1 –38, a neuropeptide with known migraine-inducing properties. Hence, our aim was to reveal the role of the peripheral kynurenine pathway (KP) in episodic migraineurs. We focused on the complete tryptophan (Trp) catabolism, which comprises the serotonin and melatonin routes in addition to kynurenine metabolites. We i...
Source: The Journal of Headache and Pain - June 25, 2021 Category: Neurology Source Type: research

Primary headaches during the COVID-19 lockdown in Germany: analysis of data from 2325 patients using an electronic headache diary
AbstractBackgroundLockdown measures due to the COVID-19 pandemic have led to lifestyle changes, which in turn may have an impact on the course of headache disorders. We aimed to assess changes in primary headache characteristics and lifestyle factors during the COVID-19 lockdown in Germany using digital documentation in the mobile application (app) M-sense.Main bodyWe analyzed data of smartphone users, who entered daily data in the app in the 28-day period before lockdown (baseline) and in the first 28  days of lockdown (observation period). This analysis included the change of monthly headache days (MHD) in the obs...
Source: The Journal of Headache and Pain - June 22, 2021 Category: Neurology Source Type: research

Thalamo-cortical networks in subtypes of migraine with aura patients
ConclusionsThe present findings suggest that, as far as MRI profiles are concerned, the two clinical phenotypes of migraine with aura have both common and distinct morpho-functional features of nodes in the thalamo-cortical network. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 19, 2021 Category: Neurology Source Type: research

A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study
ConclusionsThis study unravels, for the first time, the gene-gene interactions betweenNRXN2,GABRE - a GABAA-receptor - andCASK, importantly it shows the synergetic effect between those genes and its relation with migraine susceptibility.These gene interactions, which may be a part of a larger network, can potentially help us in better understanding migraine aetiology and in development of new therapeutic approaches. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 14, 2021 Category: Neurology Source Type: research

Correction to: Burden of migraine and unmet needs from the patients ’ perspective: a survey across 11 specialized headache clinics in Korea
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 11, 2021 Category: Neurology Source Type: research

Migraine and neuroinflammation: the inflammasome perspective
ConclusionNeuroinflammatory pathways, specifically those involving inflammasome proteins, seem promising candidates as treatment targets, and perhaps even biomarkers, in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 10, 2021 Category: Neurology Source Type: research

Editorial. Valuing headache ’s solution
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 10, 2021 Category: Neurology Source Type: research

Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study
ConclusionsIn this multicentre study, clinical factors relevant to headache-related disability, such as new-onset headache, stress and sleep disturbances, were identified, highlighting the importance of symptom management in migraine patients during the first wave of the COVID-19 pandemic. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 7, 2021 Category: Neurology Source Type: research

The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
ConclusionsOur findings demonstrate that changes after VTA-DBS in CH-QoL total scores are associated with the reduction of frequency, duration, and severity of headache attacks after surgery. Moreover, post VTA-DBS improvement in CH-QoL scores  is associated with an amelioration in quality of life assessed with generic measures, a reduction of depressive symptoms, and evaluative pain experience after VTA-DBS. These results support the sensitivity to change of the CH-QoL and further demonstrate the validity and applicability of CH-QoL as a disease specific measure of quality of life for CH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 6, 2021 Category: Neurology Source Type: research

Cytokine and interleukin profile in patients with headache and COVID-19: A pilot, CASE-control, study on 104 patients
ConclusionsThe higher levels of IL-10 -an anti-inflammatory cytokine- found in our sample in patients with headache may be explained as a counteract of cytokine release, reflecting a more intense immune response in these patients. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 4, 2021 Category: Neurology Source Type: research

Real-life use of onabotulinumtoxinA reduces healthcare resource utilization in individuals with chronic migraine: the REPOSE study
AbstractBackgroundChronic migraine (CM) is associated with substantial economic burden. Real-world data suggests that onabotulinumtoxinA treatment for CM reduces healthcare resource utilisation (HRU) and related costs.MethodsREPOSE was a 2-year prospective, multicentre, non-interventional, observational study to describe the real-world use of onabotulinumtoxinA in adult patients with CM. This analysis examined the impact of onabotulinumtoxinA on HRU. Patients received onabotulinumtoxinA treatment approximately every 12  weeks according to their physicians’ discretion, guided by the summary of product character...
Source: The Journal of Headache and Pain - June 2, 2021 Category: Neurology Source Type: research

The prevalence and burden of recurrent headache in Australian adolescents: findings from the longitudinal study of Australian children
ConclusionsRecurrent headache was common among Australian adolescents and increased in prevalence for females, across the age groups. Frequent recurrent headache is burdensome for both male and female adolescents. This study provides information regarding the prevalence and burden of recurrent headache in the adolescent population based on findings from the Longitudinal Study of Australian Children. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 1, 2021 Category: Neurology Source Type: research

Shift from high-frequency to low-frequency episodic migraine in patients treated with Galcanezumab: results from two global randomized clinical trials
ConclusionsIn patients with HFEM, treatment with galcanezumab (120  mg and 240 mg) significantly reduced migraine headache days/month, maintained remission status at subsequent months until the end of the study, and improved patients’ quality of life versus placebo.Trial registrationClinicalTrials.gov Identifier: EVOLVE-1,NCT02614183; EVOLVE-2,NCT02614196. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 28, 2021 Category: Neurology Source Type: research

Activation of CamKII α expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model
ConclusionsThis article presents the prospect of pain modulation in trigeminal pain pathway via optogenetic activation of vlPAG excitatory neurons in rat model. This outlook could potentially assist vlPAG insight and its optogenetic approach in trigeminal neuropathic pain which aid clinicians endeavoring towards enhanced pain relief therapy in trigeminal neuralgia patients. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 27, 2021 Category: Neurology Source Type: research

Correction to: Safety and tolerability of eptinezumab in patients with migraine: a pooled analysis of 5 clinical trials
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 25, 2021 Category: Neurology Source Type: research

Burden of migraine and unmet needs from the patients ’ perspective: a survey across 11 specialized headache clinics in Korea
ConclusionKorean patients with migraine experience significant disability and reduced quality of life as a result of the disease and have clear unmet needs in terms of diagnosis, understanding of the disease, and disease management including treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 24, 2021 Category: Neurology Source Type: research

Post-traumatic trigeminal neuropathy: correlation between objective and subjective assessments and a prediction model for neurosensory recovery
ConclusionsWe found a strong correlation of subjective well-being with the presence of brush stroke allodynia, thermal and/or mechanical hyperesthesia, and the size of the neuropathic area. These results suggest that positive symptoms dominate the effect on affect. In patients reporting poor subjective well-being in the absence of positive symptoms or a large neuropathic area, additional attention towards psychosocial triggers might enhance treatment outcome. The prediction model could contribute to establishing realistic expectations about the likelihood of neurosensory recovery but remains to be validated in future studi...
Source: The Journal of Headache and Pain - May 24, 2021 Category: Neurology Source Type: research

InterMiG: international differences in the therapeutic approach to migraine patients in specialized headache centers
AbstractBackgroundThere is currently a wide therapeutic arsenal for migraine patients, without a single first-line preventive drug and we choose the different available alternatives taking into account comorbidities, national guidelines, previous treatments and personal experiences.Our objective was to evaluate the differences in the use of migraine treatments between neurologists from different countries.MethodsThis is a multi-centre observational study carried out by neurologists from specialized headache units in seven countries, retrospective with consecutive inclusion of all patients presenting with a migraine diagnos...
Source: The Journal of Headache and Pain - May 24, 2021 Category: Neurology Source Type: research

Clinical, psychological, and sensory characteristics associated with headache attributed to temporomandibular disorder in people with chronic myogenous temporomandibular disorder and primary headaches
ConclusionsHATMD is highly prevalent among patients with chronic myogenous TMD and headaches and often presents as migraine. In contrast to primary headaches, HATMD is associated with higher headache frequency and examination-evoked masticatory muscle pain, but with surprisingly few measures of facial pain, general health, and psychological distress. A better understanding of HATMD is necessary for developing targeted strategies for its management.Trial identification and registrationSOPPRANO;NCT02437383. Registered May 7, 2015. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 22, 2021 Category: Neurology Source Type: research

The impact of COVID-19 pandemic on headache symptoms and drug withdrawal among patients with medication overuse headache: a cross-sectional study
ConclusionsOur findings reflect that MOH patients experienced a worse relief of headache symptoms and drug withdrawal during the pandemic. Available access to regular prophylactic medications was the significant independent factor for improvement of headache symptoms. Male sex was significantly associated with decreased days with acute medications per month. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 21, 2021 Category: Neurology Source Type: research

Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura
ConclusionsThis study identified abnormal visual FC along with other core networks differentiating anxiety comorbidity from MwoA. This may therefore enhance the understanding of the neuropsychological basis of psychiatric comorbidities and provide novel insights that may help in the discovery of new marks or even treatment targets. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 21, 2021 Category: Neurology Source Type: research

Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & amp; Headache Alliance
ConclusionsThis report highlights the clinical relevance of difficult-to-treat migraine and the presence of unmet needs in this field. There is the need of more evidence regarding the management of those patients and clear guidance referring to the organization of care and available opportunities. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 18, 2021 Category: Neurology Source Type: research

Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice
ConclusionThese results indicate that unilateral injection of BoNT/A attenuated bilateral mechanical pain hypersensitivity and anxiety-like behaviors in dIoN-CCI mice, and the analgesic effects of BoNT/A may be associated with the inhibition of TLR2-mediated neuroinflammation in the TNC. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 17, 2021 Category: Neurology Source Type: research

Long term safety, tolerability, and efficacy of intracutaneous zolmitriptan (M207) in the acute treatment of migraine
ConclusionsThe majority of participants experienced cutaneous adverse reactions such as application site erythema, swelling, and bleeding, and most reactions were scored as mild. These results are consistent with what was observed in the single migraine attack treatment ZOTRIP trial indicating that M207 is well tolerated in the setting of longer-term repeated use. Efficacy findings were also similar to those in the ZOTRIP trial.Trial registrationClinicaltrials.gov on September 13, 2017 (NCT03282227). (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 17, 2021 Category: Neurology Source Type: research

Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study
ConclusionsIn CM patients, MOH is associated with an increased risk for suicidal ideation and prior suicide attempt, which deserves attention for clinicians taking care of headache patients. However, further studies are needed to determine the causal relationship, as well as the underlying pathophysiology. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - May 10, 2021 Category: Neurology Source Type: research