Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
ConclusionThis study reveals that SFKs activity transmits P2X7 receptor signaling to facilitate CSD propagation via glutamatergic pathway and promote neuroinflammation, which is of particular relevance to migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - December 4, 2021 Category: Neurology Source Type: research

Major sex differences in migraine prevalence among occupational categories: a cross-sectional study using UK Biobank
ConclusionOur results show that migraine is genderdependently associated with physically demanding jobs and shift working. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - December 4, 2021 Category: Neurology Source Type: research

Which is the best transcranial direct current stimulation protocol for migraine prevention? A systematic review and critical appraisal of randomized controlled trials
ConclusionsBoth anodal and cathodal tDCS are promising for migraine prevention. However, there is a need for larger and rigorous RCTs and standardized procedures. Additionally, the potential benefits and targeted neurostimulation protocols should be assessed for specific subgroups of patients. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 27, 2021 Category: Neurology Source Type: research

Cardiovascular outcomes in adults with migraine treated with eptinezumab for migraine prevention: pooled data from four randomized, double-blind, placebo-controlled studies
ConclusionsIn this post hoc analysis of four clinical trials for eptinezumab, doses of 100  mg, 300 mg, and 1000 mg (more than 3 times the highest approved dose) were not associated with clinically relevant changes in vital signs or significant changes in concomitant cardiovascular medication usage, and had low incidences of cardiovascular TEAEs, comparable to placebo.Trial registrationNCT01772524 (Study 2), 01/21/2013;NCT02275117 (Study 5), 10/27/2014;NCT02559895 (PROMISE-1), 09/25/2017;NCT02974153 (PROMISE-2), 11/28/2016 (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 25, 2021 Category: Neurology Source Type: research

Efficacy and safety of fremanezumab in clinical trial participants aged ≥60 years with episodic or chronic migraine: pooled results from 3 randomized, double-blind, placebo-controlled phase 3 studies
AbstractBackgroundAlthough migraine is less common in older people, preventive treatment of migraine in these individuals may be more challenging due to the presence of multiple comorbidities and polypharmacy. Additionally, evidence for migraine treatment efficacy, safety, and tolerability is limited in this population. We evaluated efficacy, safety, and tolerability of fremanezumab, a fully humanized monoclonal antibody (IgG2 Δa) that selectively targets calcitonin gene–related peptide (CGRP), in clinical trial participants aged ≥60 years with episodic migraine (EM) or chronic migraine (CM).MethodsTh...
Source: The Journal of Headache and Pain - November 24, 2021 Category: Neurology Source Type: research

Metabolic profile  changes in serum of migraine patients detected using 1H-NMR spectroscopy
ConclusionThis study indicates that metabolic profiles, based on serum concentrations of several metabolites, including lipids, amino acids and metabolites of glucose metabolism, can distinguish active migraine patients from controls. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 24, 2021 Category: Neurology Source Type: research

Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
ConclusionThis study shows that migraineurs have increased grey matter volume in the lingual gyrus, which can be modified by tDCS. Tracking structural plasticity in migraineurs provides a potential neuroimaging biomarker for treatment monitoring.Trial registrationClinicalTrials.gov,NCT03237754. Registered 03 August 2017 – retrospectively registered,https://clinicaltrials.gov/ct2/show/NCT03237754. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 20, 2021 Category: Neurology Source Type: research

Total health insurance costs in children with a migraine diagnosis compared to a control group
Conclusion6 to 11  year old children with a migraine diagnosis cause significant direct and comorbidity related excess costs in the German health care system. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 20, 2021 Category: Neurology Source Type: research

The International Headache Congress – IHS and EHF joint congress 2021: late breaking abstracts
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 18, 2021 Category: Neurology Source Type: research

Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine
ConclusionExperimental studies in animals and emerging imaging findings from patients warrant further research to gain deeper insight to the complex role of inflammatory signaling in headache generation in migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 18, 2021 Category: Neurology Source Type: research

Altered static and dynamic functional network connectivity in post-traumatic headache
ConclusionsMTBI patients with PTH are characterized with altered sFNC and dFNC, which could provide new perspective to understand the neuropathological mechanism underlying the PTH to determine more appropriate management, and may be a useful imaging biomarker for identifying and predicting mTBI with PTH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 13, 2021 Category: Neurology Source Type: research

The management and clinical knowledge of headache disorders among general practitioners in Norway: a questionnaire survey
ConclusionThe knowledge of management of CTTH and MOH was moderate compared to migraine among Norwegian GPs. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 11, 2021 Category: Neurology Source Type: research

Correction to: Clinical symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 9, 2021 Category: Neurology Source Type: research

Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
ConclusionOur study clearly shows that freedom from headache is not caused by a lower general pain sensitivity. The results support the hypothesis that headache is caused by specific mechanisms, which are present in the primary headache disorders, rather than by a decreased general sensitivity to painful stimuli.Trial registrationRegistered at ClinicalTrials.gov (NCT04217616),  3rd January 2020, retrospectively registered. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 8, 2021 Category: Neurology Source Type: research

Real-world evidence data on the monoclonal antibody erenumab in migraine prevention: perspectives of treating physicians in Germany
ConclusionsTELESCOPE confirms positive treatment responses with erenumab shown in clinical trials in a real-world multi-centre setting. The results show consistently positive experiences of physicians utilizing erenumab in clinical practice and underline that therapy with this monoclonal antibody is effective in migraine patients, particular in those, who have failed several prophylactic therapies. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 6, 2021 Category: Neurology Source Type: research

Safety findings from CENTURION, a phase 3 consistency study of lasmiditan for the acute treatment of migraine
We present detailed safety findings from the placebo-controlled, double-blind Phase 3 study, of LTN treatment across 4 attacks (CENTURION).MethodsPatients were randomized 1:1:1 to LTN 200  mg (LTN200), LTN100, or a control group that received placebo for 3 attacks and LTN50 for either the 3rd or 4th attack (1:1). Safety analyses were conducted for patients who took ≥1 dose of study drug and, in some cases, those who took all 4 doses.ResultsOverall, 1471 patients treated 4494 attacks. The incidences of treatment-emergent serious adverse events (SAEs) were - placebo,n=2 (0.4  %); LTN100,n=1 (0.2  %); LT...
Source: The Journal of Headache and Pain - November 6, 2021 Category: Neurology Source Type: research

Correction to: Psychological predictors of negative treatment outcome with Erenumab in chronic migraine: data from an open label long-term prospective study
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - November 3, 2021 Category: Neurology Source Type: research

Regional homogeneity alterations in multi-frequency bands in tension-type headache: a resting-state fMRI study
ConclusionsThe results showed that the superior frontal gyrus and middle frontal gyrus were involved in the integration and processing of pain signals. In addition, the abnormal spontaneous neural activity in TTH patients was frequency-specific. Namely, slow-5 band (0.01 –0.027 Hz) might contain additional useful information in comparison to slow-4 band (0.027−0.073 Hz). This preliminary exploration might provide an objective imaging basis for the understanding of the pathophysiological mechanism of TTH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 28, 2021 Category: Neurology Source Type: research

CGRP monoclonal antibodies in migraine: an efficacy and tolerability comparison with standard prophylactic drugs
ConclusionsBalancing the data presented in the current manuscript with additional data concerning long term safety on the one hand and cost issues on the other hand, can be of particular use to health policy makers to implement this new drug class in the prevention of migraine. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 25, 2021 Category: Neurology Source Type: research

Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study
ConclusionsClinical care may impact GMV in migraine patients. Patients may need different treatment options to address this baseline deficit.Trial registrationNCT02133209. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 23, 2021 Category: Neurology Source Type: research

Minimal important change and responsiveness of the Migraine Disability Assessment Score (MIDAS) questionnaire
ConclusionsThis study showed that MIDAS has a limited responsiveness to change. A change of 4.5 points or more represents a clinically important change for patients with high frequent migraine and chronic migraine receiving non-pharmacological treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 21, 2021 Category: Neurology Source Type: research

Clinical symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study
AbstractBackgroundTo compare symptoms of clinical androgen deficiency between men with migraine, men with cluster headache and non-headache male controls.MethodsWe performed a cross-sectional study using two validated questionnaires to assess symptoms of androgen deficiency in males with migraine, cluster headache, and non-headache controls. Primary outcome was the mean difference in androgen deficiency scores. Generalized linear models were used adjusting for age, BMI, smoking and lifetime depression. As secondary outcome we assessed the percentage of patients reporting to score below average on four sexual symptoms (bear...
Source: The Journal of Headache and Pain - October 19, 2021 Category: Neurology Source Type: research

Risk for ischemic stroke and coronary heart disease associated with migraine and migraine medication among older adults
ConclusionsOlder adults with migraine are at increased risk for ischemic stroke. The risk for ischemic stroke among older adults with migraine may differ by migraine medication classes. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 13, 2021 Category: Neurology Source Type: research

Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
ConclusionsThis review highlights that at the epidemiological and clinical level, obesity increases morbidity in migraine and IIH headache, where weight loss can improve headache morbidity. However, further research is required to understand the molecular underpinnings of obesity related headache in order to generate novel treatments. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 10, 2021 Category: Neurology Source Type: research

Inflammatory complications of CGRP monoclonal antibodies: a case series
ConclusionThis case series provides novel insights on the potential molecular mechanisms and side-effects of CGRP antagonism in migraine and supports clinical vigilance in patient care going forward. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 9, 2021 Category: Neurology Source Type: research

Angioarchitectural features amongst patients with unruptured brain arteriovenous malformations presenting with headache: findings from a single center retrospective review of 76 patients
ConclusionsOur study suggests that the absence of venous stenosis may contribute to headache symptomatology. This serves as a basis for further study of correlations between AVM angioarchitecture and symptomatology to direct headache management in AVM patients. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 9, 2021 Category: Neurology Source Type: research

Prenatal oestrogen-testosterone balance as a risk factor of migraine in adults
ConclusionsOur results suggest that depending on sex, different proportion of prenatal sex steroids might be a risk factor of migraine in adults. Women with migraine were presumably exposed in prenatal life to higher testosterone levels relative to oestrogen, while men with migraine were probably exposed in prenatal life to higher levels of oestrogen relative to testosterone. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 7, 2021 Category: Neurology Source Type: research

Anti-CGRP monoclonal antibodies in chronic migraine with medication overuse: real-life effectiveness and predictors of response at 6  months
AbstractBackgroundIn daily practice, anti-CGRP monoclonal antibodies (MAbs) may be useful in chronic migraine (CM) with medication overuse (MO), but data is limited. We evaluated their effectiveness in a real-life clinical cohort.MethodsThis is a prospective study conducted in CM patients with and without medication overuse treated with monthly MAbs during 6  months (erenumab/galcanezumab). We collected headache characteristics, including acute medication intake, through an electronic diary. We compared patients (1) with and without MO at baseline, (2) with and without ongoing MO after treatment, defining MO resolution as
Source: The Journal of Headache and Pain - October 7, 2021 Category: Neurology Source Type: research

Intracranial pressure directly predicts headache  morbidity in idiopathic intracranial hypertension
AbstractObjectiveHeadache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate the association with intracranial pressure.MethodsIIH:WT was a randomised controlled parallel group multicentre trial in the United Kingdom investigating weight management methods in IIH. Participants with active IIH (evidenced by papilloedema) and a body mass index (BMI) ≥35 kg/m2 were recruited. At baseline, 12  months and 24 months headache characteristics and quality of life outcome measures were collected and lumbar puncture measurements were ...
Source: The Journal of Headache and Pain - October 7, 2021 Category: Neurology Source Type: research

Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis
ConclusionsIt is concluded that enhanced inflammatory and immune cell activity, and oxidative stress can play a role in migraine susceptibility and headache generation. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 6, 2021 Category: Neurology Source Type: research

Correction to: Manual joint mobilisation techniques, supervised physical activity, psychological treatment, acupuncture and patient education for patients with tension-type headache. A systematic review and meta-analysis
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 6, 2021 Category: Neurology Source Type: research

Correction to: CGRP induces migraine-like symptoms in mice during both the active and inactive phases
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - October 5, 2021 Category: Neurology Source Type: research

Psychological predictors of negative treatment outcome with Erenumab in chronic migraine: data from an open label long-term prospective study
In this study, we evaluated the psychological predictors of the outcome of treatment with the anti-CGRP monoclonal antibody erenumab in patients with chronic migraine (CM).MethodsSeventy-five patients with CM who had already failed at least 3 preventive therapies received erenumab every 28  days for a period of 12 months. Before the first administration, patients received a full psychological evaluation using The Structured Clinical Interview for DSM-5 Clinician Version (SCID-5-CV) to assess personality disturbances (primary outcome), mood and anxiety disorders, and as well specif ic questionnaires to evaluat...
Source: The Journal of Headache and Pain - October 2, 2021 Category: Neurology Source Type: research

Efficacy of galcanezumab in patients with migraine and history of failure to 3 –4 preventive medication categories: subgroup analysis from CONQUER study
AbstractBackgroundChronic migraine (CM) and episodic migraine (EM) are associated with substantial headache-related disability, poor quality of life and global societal burden. In this subgroup analysis from the CONQUER study, we report efficacy outcomes from a pre-specified analysis of galcanezumab versus placebo in patients with CM or EM and 3 –4 prior preventive medication category failures due to inadequate efficacy (after at least 2 months at maximum tolerated dose), or safety or tolerability reasons. The patient population is of particular interest due to evidence of decreased quality of life and increas...
Source: The Journal of Headache and Pain - September 30, 2021 Category: Neurology Source Type: research

Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia
ConclusionsThese findings, generated through a highly sensitive 7  T MRI protocol, provide compelling support for the theory that TN neurobiology is a complex amalgamation of local structural changes within the trigeminal nerve and structural alterations in subnuclei of limbic structures directly and indirectly involved in nociception and pain processing. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 23, 2021 Category: Neurology Source Type: research

CGRP antibody therapy in patients with drug resistant migraine and chronic daily headache: a real-world experience
ConclusionsDespite the low responder rate, CGRP antibodies can be effective at least in a few cases of severely affected patients with drug resistant migraine and chronic daily headache.Trial registrationRetrospective registered. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 20, 2021 Category: Neurology Source Type: research

Efficacy and safety of erenumab in Japanese migraine patients with prior preventive treatment failure or concomitant preventive treatment: subgroup analyses of a phase 3, randomized trial
ConclusionErenumab was associated with clinically relevant improvements in all efficacy endpoints and was well tolerated across all subgroups of Japanese migraine patients with/without prior preventive treatment failure(s) and with/without concomitant preventive treatment.Trial registrationClinicaltrials.gov. NCT03812224. Registered January 23, 2019. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 18, 2021 Category: Neurology Source Type: research

Osmophobia in primary headache patients: associated symptoms and response to preventive treatments
AbstractBackgroundOsmophobia, is common among primary headaches, with prevalence of migraine.The study aimed to evaluate prevalence and clinical characteristics of patients with osmophobia in a cohort of primary headache patients selected at a tertiary headache center. The second aim was to verify the possible predicting role of osmophobia in preventive treatment response in a sub cohort of migraine patients.MethodsThis was an observational retrospective cohort study based on data collected in a tertiary headache center.We selected patients aged 18 –65 years, diagnosed as migraine without aura (MO), migraine w...
Source: The Journal of Headache and Pain - September 18, 2021 Category: Neurology Source Type: research

Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis
AbstractBackgroundHeadache is a frequent symptom following COVID-19 immunization with a typical onset within days post-vaccination. Cases of cerebral venous thrombosis (CVT) have been reported in adenovirus vector-based COVID-19 vaccine recipients.FindingsWe reviewed all vaccine related CVT published cases by April 30, 2021. We assessed demographic, clinical variables and the interval between the vaccination and onset of headache. We assessed whether the presence of headache was associated with higher probability of death or intracranial hemorrhage.We identified 77 cases of CVT after COVID-19 vaccination. Patients ’ ...
Source: The Journal of Headache and Pain - September 17, 2021 Category: Neurology Source Type: research

Migraine patients in Germany - need for medical recognition and new preventive treatments: results from the PANORAMA survey
ConclusionsPANORAMA gives a comprehensive overview of the migraine healthcare landscape in Germany in 2017/2018, elucidates a lack of common treatment algorithms and reveals a high demand for defined therapy strategies and new prophylactic treatment going forwards. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 9, 2021 Category: Neurology Source Type: research

Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study
ConclusionsThe current study supported MOH to be lying within a spectrum of dependence and addiction disorder. The enhanced functional connectivity of the habenula with SN may correlate to the development or chronification of MOH. Furthermore, the habenula may be an indicator or treatment target for MOH for its integrative role involved in multiple aspects of MOH. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 9, 2021 Category: Neurology Source Type: research

CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater
ConclusionsWe conclude that only a small fraction of CGRP applied onto the dura mater reaches the jugular blood and, in a delayed manner, also the CSF. The dura mater may constitute a barrier for CGRP and limits diffusion into the CSF of the subarachnoidal space, where the CGRP concentration is too low to cause vasodilatation. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 8, 2021 Category: Neurology Source Type: research

The International Headache Congress – IHS and EHF joint congress 2021
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 7, 2021 Category: Neurology Source Type: research

Flatness of the Meckel cave may cause primary trigeminal neuralgia: a radiomics-based study
ConclusionsBy providing a method to analyze the morphology of the MC, we found that there is an asymmetry in the morphology of bilateral MC in the PTN and HC groups. It can be inferred that the flatness of the MC may be a cause of PTN. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - September 3, 2021 Category: Neurology Source Type: research

Disconnectome of the migraine brain: a “connectopathy” model
AbstractBackgroundIn the past decades a plethora of studies has been conducted to explore resting-state functional connectivity (RS-FC) of the brain networks in migraine with conflicting results probably due to the variability and susceptibility of signal fluctuations across the course of RS-FC scan. On the other hand, the structural substrates enabling the functional communications among the brain connectome, characterized by higher stability and reproducibility, have not been widely investigated in migraine by means of graph analysis approach. We hypothesize a rearrangement of the brain connectome with an increase of bot...
Source: The Journal of Headache and Pain - August 28, 2021 Category: Neurology Source Type: research

A close association of freedom from pain, migraine-related functional disability, and other outcomes: results of a post hoc analysis of randomized lasmiditan studies SAMURAI and SPARTAN
AbstractBackgroundWhile pain freedom at 2  h is a key primary outcome for current trials for acute treatment of migraine, the relationship between the degree of head pain and other efficacy measures at 2 h has rarely been explored. Following lasmiditan treatment of a migraine attack with moderate or severe head pain, we contrast those w ho achieve pain freedom with those who achieve mild pain but not pain freedom 2 h post dosing.MethodsPatient-level data were pooled across studies and treatment arms from two Phase 3 trials comparing lasmiditan and placebo, SAMURAI and SPARTAN. This post hoc analysis as...
Source: The Journal of Headache and Pain - August 28, 2021 Category: Neurology Source Type: research

Correction to: Effect of galcanezumab on severity and symptoms of migraine in phase 3 trials in patients with episodic or chronic migraine
(Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 26, 2021 Category: Neurology Source Type: research

Structured headache services as the solution to the ill-health burden of headache. 2. Modelling effectiveness and cost-effectiveness of implementation in Europe: methodology
ConclusionsThis study presents the first headache-type-specific analytical models to evaluate effectiveness and cost-effectiveness of implementing structured headache services in countries in the European Region. The models are robust, and can assist policy makers in allocating health budgets between interventions to maximize the health of populations. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 23, 2021 Category: Neurology Source Type: research

Coronavirus disease-19 and headache; impact on pre-existing and characteristics of de novo: a cross-sectional study
AbstractBackgroundCoronavirus disease-19 is caused by the severe acute respiratory syndrome coronavirus 2 Headache is a common symptom during and after Coronavirus disease-19. We aimed to study headache character in relation to COVID-19.MethodsThis was a cross-sectional study. Patients who had Coronavirus disease-19, confirmed by reverse transcription polymerase chain reaction technique and presented to the headache clinic within 3  months after the onset of infections were identified to the study. Study included patients diagnosed as primary headache disorders according to The International Classification of Headac...
Source: The Journal of Headache and Pain - August 21, 2021 Category: Neurology Source Type: research

Investigation of cortical thickness and volume during spontaneous attacks of migraine without aura: a 3-Tesla MRI study
ConclusionSpontaneous migraine attacks are accompanied by transient reduced cortical thickness and volume in pain-related areas. The findings constitute a fingerprint of acute pain in migraine patients, which can be used as a possible biomarker to predict antimigraine treatment effect in future studies.Trial registrationThe study was registered atClinicalTrials.gov (NCT02202486). (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 21, 2021 Category: Neurology Source Type: research