Magnetic Particle Imaging of Macrophages Associated with Cancer: Filling the Voids Left by Iron-Based Magnetic Resonance Imaging
ConclusionsMPI provides quantitative information onin vivo iron labeling of macrophages that is not attainable with MRI. The optimal iron nanoparticle for MPI in general is still under investigation; however, for MPI imaging of macrophages labeledin vivo by intravenous administration, Ferumoxytol nanoparticles were superior to Ferucarbotran. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 13, 2020 Category: Molecular Biology Source Type: research

Response to: Letter to the Editors: Re: Simultaneous PET/MRI in the Evaluation of Breast and Prostate Cancer Using Combined Na[ 18 F]F and [ 18 F]FDG: A Focus on Skeletal Lesions
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 13, 2020 Category: Molecular Biology Source Type: research

The Myocardial Microenvironment Modulates the Biology of Transplanted Mesenchymal Stem Cells
ConclusionsThe ischemic myocardium induces changes in the phenotype of transplanted MSCs. Despite their limited survival, MSCs still elicit a certain therapeutic response, as evidenced by improvement in myocardial remodeling and cardiac function. Maximization of the survival and reparative efficacy of stem cells remains a key for the success of stem cell therapies. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 6, 2020 Category: Molecular Biology Source Type: research

Synthesis and Application of a Long-Circulating Radiolabeled Peptide for Targeting of Osteosarcoma
ConclusionsOverall, the introduction of the EB motif to TMTP1 significantly changed its pharmacokineticsin vivo, and this strategy fulfills the purpose of prolonging the blood circulation and enhancing the tumor uptake. [64Cu]DOTA-EB-TMTP1 is a promising agent for osteosarcoma targeting. Moreover, our study highlights that DOTA-EB-TMTP1 is a good candidate for labeling with different radionuclides for potential theranostic applications. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 6, 2020 Category: Molecular Biology Source Type: research

Glutamate-Weighted CEST Contrast After Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor
AbstractPurposeTo mitigate the effect of magnetization transfer (MT) from glutamate-weighted chemical exchange saturation transfer (GluCEST) contrast in healthy human brain and its demonstration in a rat brain tumor model.ProceduresGluCEST data was acquired from six healthy human volunteers at 7T and on a rat brain with tumor at 9.4  T. Single voxel proton magnetic resonance spectroscopy (1HMRS) data was acquired from three human volunteers. The magnetic resonance imaging protocol included CEST data acquisition at multiple frequencies for generating Z-spectra, B0 and B1 map. Partial Z-spectra at offset frequencies fro...
Source: Molecular Imaging and Biology - January 6, 2020 Category: Molecular Biology Source Type: research

Modeling of [ 18 F]FEOBV Pharmacokinetics in Rat Brain
Conclusion[18F]FEOBV is best modeled using the irreversible 2TCM or Patlak graphical analysis. SUV should only be used if blood sampling is not possible. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 6, 2020 Category: Molecular Biology Source Type: research

Correction to: Letter to the Editor re: Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake
The article was updated to correct the following errors due to an error in production: (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - January 6, 2020 Category: Molecular Biology Source Type: research

European Molecular Imaging Meeting 2020: Be Invited to Thessaloniki, Greece
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 20, 2019 Category: Molecular Biology Source Type: research

Optimization of Keyhole Imaging Parameters for Glutamate Chemical Exchange Saturation Transfer MRI at 7.0  T
ConclusionsCombining the keyhole imaging technique with GluCEST imaging enables stable image reconstruction and quantitative evaluation, and this approach is potentially applicable in various CEST imaging applications. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 19, 2019 Category: Molecular Biology Source Type: research

Noninvasive Imaging for Assessment of the Efficacy of Therapeutic Agents for Hepatocellular Carcinoma
AbstractMorphological imaging techniques are typically used in the anti-cancer drug efficacy evaluation process. However, these techniques can evaluate the therapeutic efficacy only when the tumor shows anatomic changes —usually at later stages, when the therapeutic effects are poor. In contrast, molecular imaging allows noninvasive monitoring of tumor growth, assessment of drug metabolism, and evaluation of therapeutic efficacy at the molecular and cellular levels. Multimodality molecular imaging, which combines the advantages of various imaging modalities, provides even more comprehensive therapeutic efficacy asses...
Source: Molecular Imaging and Biology - December 13, 2019 Category: Molecular Biology Source Type: research

Letter to the Editor re: “Semiquantitative Parameters in PSMA-Targeted PET Imaging with [ 18 F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake”
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 12, 2019 Category: Molecular Biology Source Type: research

Targeting Phosphatidylethanolamine with Fluorine-18 Labeled Small Molecule Probe for Apoptosis Imaging
ConclusionConsidering the facile preparation and improved biological properties, Al[18F]F-NOTA-PEG3-duramycin seems to be a promising PET tracer candidate for imaging apoptosis in the monitoring of cancer treatment. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 11, 2019 Category: Molecular Biology Source Type: research

In Response to Letter from Fregonara et al. 2019
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 11, 2019 Category: Molecular Biology Source Type: research

Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models
ConclusionsOur findings strongly suggest that MSCs do not home to injured kidneys. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 10, 2019 Category: Molecular Biology Source Type: research

Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer
ConclusionsNanoICG is an efficacious intraoperative contrast agent and could potentially improve surgical outcomes in breast cancer. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 9, 2019 Category: Molecular Biology Source Type: research

Comparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging
ConclusionsSS180 exhibits greater TBRsin vivo, but notex vivo. These findings suggest that SS180 may have weaker fluorescence, but superior contrast. Studies in large animal models and clinical trials may better elucidate the clinical value of a long Stokes shift. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 9, 2019 Category: Molecular Biology Source Type: research

Simultaneous PET/MRI in the Evaluation of Breast and Prostate Cancer Using Combined Na[ 18 F]F and [ 18 F]FDG: a Focus on Skeletal Lesions
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 5, 2019 Category: Molecular Biology Source Type: research

Correction to: Differentiation of Malignant and Benign Head and Neck Tumors with Amide Proton Transfer-Weighted MR Imaging
This article is about head and neck tumor MR imaging and is not within the scope of two National Institutes of Health grants (R0ICA166171, ROICA228188) erroneously listed. Thus, the authors would like to remove the reference to the NIH grants R01CA166171 and R01CA228188 in this article. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 5, 2019 Category: Molecular Biology Source Type: research

In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease
AbstractStem cell-based therapeutics is a rapidly developing field associated with a number of clinical challenges. One such challenge lies in the implementation of methods to track stem cells and stem cell-derived cells in experimental animal models and in the living patient. Here, we provide an overview of cell tracking in the context of cardiac and neurological disease, focusing on the use of iron oxide-based particles (IOPs) visualizedin vivo using magnetic resonance imaging (MRI). We discuss the types of IOPs available for such tracking, their advantages and limitations, approaches for labeling cells with IOPs, biolog...
Source: Molecular Imaging and Biology - December 4, 2019 Category: Molecular Biology Source Type: research

Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N-[ 11 C]Methyl-AMD3465 PET
AbstractPurposeChemokine CXCL12 and its receptor CXCR4 are constitutively overexpressed in human cancers. The CXCL12-CXCR4 signaling axis plays an important role in tumor progression and metastasis, but also in treatment-induced recruitment of CXCR4-expressing cytotoxic immune cells. Here, we aimed to demonstrate the feasibility of N-[11C]methyl-AMD3465 positron emission tomography (PET) to monitor changes in CXCR4 density in tumors after single-fraction local radiotherapy or in combination with immunization.ProcedureTC-1 cells expressing human papillomavirus antigens E6 and E7 were inoculated into the C57BL/6 mice subcuta...
Source: Molecular Imaging and Biology - December 4, 2019 Category: Molecular Biology Source Type: research

Correction to: The 2019 World Molecular Imaging Congress (WMIC) and Molecular Imaging and Biology (MIB) Awards
The Commercial Innovation of the Year Award went to Emile Beaulieu of Photonetc. for their work. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 4, 2019 Category: Molecular Biology Source Type: research

Integrin α6-Targeted Magnetic Resonance Imaging of Hepatocellular Carcinoma in Mice
ConclusionThese findings potentiate the use of RWY-dL-(Gd-DOTA)4 for the MRI of HCC to improve the diagnosis of HCC. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 2, 2019 Category: Molecular Biology Source Type: research

Changing of the Guard at Molecular Imaging & amp; Biology
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 2, 2019 Category: Molecular Biology Source Type: research

In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [ 11 C]ITDM in Mice
This study aimed at investigating binding specificity, suitability of reference region-based kinetic modelling, and pharmacokinetics of the metabotropic glutamate receptor 1 (mGluR1) radioligand [11C]ITDM in mice.ProceduresWe performedin vivo blocking as well as displacement of [11C]ITDM during positron emission tomography (PET) imaging using the specific mGluR1 antagonist YM-202074. Additionally, we assessedin vitro blocking of [3H]ITDM at two different doses of YM-202074. As an alternative to reference region models, we validated the use of a noninvasive image-derived input function (IDIF) compared to an arterial input f...
Source: Molecular Imaging and Biology - December 2, 2019 Category: Molecular Biology Source Type: research

Relationship Between Tumor Immune Markers and Fluorine-18- α-Methyltyrosine ([ 18 F]FAMT) Uptake in Patients with Lung Cancer
ConclusionsThe uptake of [18F]FAMT on PET imaging was significantly correlated with PD-L1 expression in NSCLC, especially in patients with AC and advanced disease. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 2, 2019 Category: Molecular Biology Source Type: research

The Effect of Chirality on the Application of 5-[ 18 F]Fluoro-Aminosuberic Acid ([ 18 F]FASu) for Oxidative Stress Imaging
ConclusionOur data suggest that pure 2S-[18F]FASu can be used to noninvasively image system xC- in a variety of cancers, either as the racemic mixture (2S,5R/S-) or optically pure form. Furthermore, this work shows potential utility of [18F]FASu for detection of glioblastoma and prostate cancer. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - December 2, 2019 Category: Molecular Biology Source Type: research

Proceedings of the World Molecular Imaging Congress 2019, Montreal Quebec, Canada September 4-7, 2019: Late-Breaking Abstracts
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 25, 2019 Category: Molecular Biology Source Type: research

Proceedings of the World Molecular Imaging Congress 2019, Montreal Quebec, Canada September 4-7, 2019: General Abstracts
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 25, 2019 Category: Molecular Biology Source Type: research

A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry
ConclusionsWe have developed a HYNIC-modified Tz derivative, and the HYNIC-PEG11-Tz was labeled with Tc-99m with a high specific activity and radiochemical purity. [99mTc]HYNIC-PEG11-Tz reacted rapidly and almost completely towards atezolizumab-TCOin vitro with the 1:1 Tz-to-mAb reaction. SPECT imaging using the pretargeted strategy (atezolizumab-TCO/[99mTc]HYNIC-PEG11-Tz) demonstrated high-contrast images for high PD-L1 expression H1975 tumor and a low background accumulation of the probe. The pretargeted imaging strategy is a powerful tool for evaluating PD-L1 expression in xenograft mice tumor models and a potential can...
Source: Molecular Imaging and Biology - November 18, 2019 Category: Molecular Biology Source Type: research

Preclinical In Vitro and In Vivo Characterization of Synaptic Vesicle 2A –Targeting Compounds Amenable to F-18 Labeling as Potential PET Radioligands for Imaging of Synapse Integrity
ConclusionsTaken together, these data suggest [18F]MNI-1126/[18F]SDM-8 (since renamed as [18F]SynVesT-1) characterizedvia anin vitro screening cascade provided a measurablein vivo SV2A specific signal in the rodent brain. This tracer as well as the close analog [18F]SDM-2 (since renamed as [18F]SynVesT-2) is currently undergoing further evaluation in preclinical and clinical studies. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - November 14, 2019 Category: Molecular Biology Source Type: research

[ 99m Tc]MIBI SPECT/CT for Identifying Dystonic Muscles in Patients with Primary Cervical Dystonia
This study aimed to evaluate the usefulness of [99mTc]sestamibi ([99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy.ProceduresThirty-six patients with PCD and 10 healthy subjects (control group) who underwent [99mTc]MIBI SPECT/CT were enrolled. The image characteristics of dystonic muscles and normal muscles were evaluated. Muscle/background ratio (MBR) of six representative muscles was calculated for dystonic muscles in PCD gro...
Source: Molecular Imaging and Biology - November 12, 2019 Category: Molecular Biology Source Type: research

Near-Infrared Imaging with Second-Window Indocyanine Green in Newly Diagnosed High-Grade Gliomas Predicts Gadolinium Enhancement on Postoperative Magnetic Resonance Imaging
In this study, we explore the ability of SWIG to detect neoplastic tissue and to predict postoperative magnetic resonance imaging (MRI) findings intraoperatively.ProceduresRetrospective data were collected from 36 patients with primary high-grade gliomas (HGG) enrolled as part of a larger trial between October 2014 and October 2018. Patients received systemic ICG infusions at 2.5 –5 mg/kg 24 h preoperatively. Near-infrared fluorescence was recorded throughout the case and from biopsy specimens. The presence/location of residual SWIG signal after resection was compared to the presence/location of residual gadolinium e...
Source: Molecular Imaging and Biology - November 11, 2019 Category: Molecular Biology Source Type: research

The 2019 World Molecular Imaging Congress (WMIC) and Molecular Imaging and Biology (MIB) Awards
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 30, 2019 Category: Molecular Biology Source Type: research

Subregional Radiomics Analysis of PET/CT Imaging with Intratumor Partitioning: Application to Prognosis for Nasopharyngeal Carcinoma
AbstractPurposeThis work aims to identify intratumoral habitats with distinct heterogeneity based on 2-deoxy-2-[18F]fluro-d-glucose positron emission tomography (PET)/X-ray computed tomography (CT) imaging, and to develop a subregional radiomics approach to predict progression-free survival (PFS) in patients with nasopharyngeal carcinoma (NPC).ProceduresIn total, 128 NPC patients (85 vs. 43 for primary vs. validation cohorts) who underwent pre-treatment PET/CT scan were enrolled retrospectively. Each tumor was partitioned into several phenotypically consistent subregions based on individual- and population-level clustering...
Source: Molecular Imaging and Biology - October 28, 2019 Category: Molecular Biology Source Type: research

Simple and Robust Intravital Microscopy Procedures in Hybrid TIE2GFP-BALB/c Transgenic Mice
ConclusionSimple intravital microscopy procedures on TIE2GFP mice allowed a real-time multi-color visualization of tissue microenvironment, underlining that robust microscopy strategies are relatively simple and can be readily available for many tissues of interest. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 24, 2019 Category: Molecular Biology Source Type: research

PET Imaging of Vesicular Monoamine Transporter 2 in Early Diabetic Retinopathy Using [ 18 F]FP-(+)-DTBZ
ConclusionsEarly DR can be non-invasively detected with PET imaging using [18F]FP-(+)-DTBZ targeting VMAT2. The expression level of VMAT2 in retina may act as a new biomarker for early DR diagnosis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 24, 2019 Category: Molecular Biology Source Type: research

Letter to the Editor re: Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [ 18 F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 22, 2019 Category: Molecular Biology Source Type: research

Letter to the Editor re: Semiquantitative Parameters in PSMA-Targeted PET Imaging with [ 18 F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake
(Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - October 17, 2019 Category: Molecular Biology Source Type: research

Quantification of [ 18 F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value
ConclusionsOur results enable the acquisition setting to be changed from a 90-min dynamic to a 20-min static PET acquisition. According to a better image quality, the 20 –40-min time-frame appears optimal. Due to its equivalence to the Vt, the SUV parameter can be considered in order to quantify [18F]UCB-H uptake in the rat brain. This work, therefore, establishes a starting point for the simplification of SV2Ain vivo quantification with [18F]UCB-H, and represents a step forward to the clinical application of this PET radiotracer. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 4, 2019 Category: Molecular Biology Source Type: research

Prognostic Impact of Intratumoral Heterogeneity Based on Fractal Geometry Analysis in Operated NSCLC Patients
ConclusionsMetabolic heterogeneity determined applying fractal principles on PET images can be considered as a novel imaging biomarker for survival in patients with NSCLC. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 4, 2019 Category: Molecular Biology Source Type: research

Contrast-Enhanced Mammography and Radiomics Analysis for Noninvasive Breast Cancer Characterization: Initial Results
ConclusionsRadiomics analysis with CEM has potential for noninvasive differentiation of tumors with different degrees of invasiveness, hormone receptor status, and tumor grade. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 28, 2019 Category: Molecular Biology Source Type: research

Noninvasive Classification of Human Triple Negative Breast Cancer by PET Imaging with GRP78-Targeted Molecular Probe [ 68 Ga]DOTA-VAP
ConclusionsGRP78-targeted PET imaging with [68Ga]DOTA-VAP provided an effective approach for the noninvasive accurate classification of TNBC from other breast cancer subtypes comparing with [18F]FDG. GRP78 may be a potential target for the diagnosis and treatment of TNBC. For clinical transformation, efforts should be made to overcome deficiencies of [68Ga]DOTA-VAP such as relative high uptake in normal tissues. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 26, 2019 Category: Molecular Biology Source Type: research

Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [ 99m Tc]Fucoidan SPECT
Conclusions[99mTc]Fucoidan SPECT/CT accurately diagnosed the autoimmune attack in the early steps of EAM and could be used to monitor disease evolution and therapy efficiency. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 20, 2019 Category: Molecular Biology Source Type: research

Comparison of Hypermetabolic and Hypoxic Volumes Delineated on [ 18 F]FDG and [ 18 F]Fluoromisonidazole PET/CT in Non-small-cell Lung Cancer Patients
AbstractPurposeThe high rates of failure in the radiotherapy target volume suggest that patients with stage II or III non-small-cell lung cancer (NSCLC) should receive an increased total dose of radiotherapy. 2-Deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and [18F]fluoromisonidazole ([18F]FMISO) (hypoxia) uptake on pre-radiotherapy positron emission tomography (PET)/X-ray computed tomography (CT) have been independently reported to identify intratumor subvolumes at higher risk of relapse after radiotherapy. We have compared the [18F]FDG and [18F]FMISO volumes defined by PET/CT in NSCLC patients included in a prospective study....
Source: Molecular Imaging and Biology - August 20, 2019 Category: Molecular Biology Source Type: research

[ 68 Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [ 68 Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence
Conclusions[68Ga]Ga-P16-093 provided diagnostic information that appeared equivalent to [68Ga]Ga-PSMA-11 in this limited series of ten prostate cancer patients presenting with biochemical recurrence, with the kidneys found to be the critical organ. Diminished tracer appearance in the urine represents a potential advantage of [68Ga]Ga-P16-093 over [68Ga]Ga-PSMA-11 for detection of lesions in the pelvis. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 19, 2019 Category: Molecular Biology Source Type: research

Contrast-Enhanced CT Texture Analysis: a New Set of Predictive Factors for Small Cell Lung Cancer
ConclusionsThe texture features of contrast-enhanced computed tomography image could potentially serve as radiological prognostic biomarkers for SCLC patients. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 19, 2019 Category: Molecular Biology Source Type: research

Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin
Conclusion[68Ga]NODAGA-duramycin PET/CT was successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice. It, therefore, represents a promising alternative to standard toxicological analyses with a high translational potential. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 8, 2019 Category: Molecular Biology Source Type: research

Imaging SERT Availability in a Rat Model of L-DOPA-Induced Dyskinesia
ConclusionsOur longitudinal PET data support a preservation of SERT availability after the induction of L-DOPA-induced dyskinesia, which is in line with previous reports in dyskinetic PD patients. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 8, 2019 Category: Molecular Biology Source Type: research

Noninvasive Photoacoustic Imaging of Dendritic Cell Stimulated with Tumor Cell-Derived Exosome
ConclusionsTEXs efficiently activated DCs and GN-labeled DC migration into LN was successfully monitored using US-guided PAI, suggesting that TEXs are a good source for DC activation and US-guided PAI is a cost-effective and easy-to-use imaging modality for noninvasive tracking of DCs. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - August 5, 2019 Category: Molecular Biology Source Type: research

Paradigms in Fluorescence Molecular Imaging: Maximizing Measurement of Biological Changes in Disease, Therapeutic Efficacy, and Toxicology/Safety
AbstractFluorescence molecular imaging (MI) is an important concept in preclinical research that focuses on the visualization of cellular and biological function in a non-invasive fashion to better understandin vivo disease processes and treatment effects. MI differs fundamentally from traditional preclinical imaging strategies in that it generally relies on reporter probes specific for particular targets or pathways that can be used to reveal biological changesin situ, at the site(s) of disease. In contrast, the more established imaging modalities, like magnetic resonance imaging, X-ray, micro X-ray computed tomography, a...
Source: Molecular Imaging and Biology - July 9, 2019 Category: Molecular Biology Source Type: research