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Exosomal microRNAs as potential circulating biomarkers in gastrointestinal tract cancers: a systematic review protocol
DiscussionThe analysis of circulating exosomal miRNA profiles provides attractive screening and non-invasive diagnostic tools for the majority of solid tumors including GI cancers. There is limited information regarding the relationship between serum exosomal miRNA profiles and the pathological condition of patients with different GI cancers. Since there is no specific biomarker for GI cancers, we aim to suggest a number of circulating exosomal miRNA candidates as potential multifaceted GI cancer biomarkers for clinical utility.Systematic review registrationPROSPEROCRD42017057129 (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2017 Category: International Medicine & Public Health Source Type: research

Mapping evidence on the distribution of human papillomavirus-related cancers in sub-Saharan Africa: scoping review protocol
DiscussionWe anticipate finding relevant literature on the distribution of HPV-related cancers in sub-Saharan Africa. The study findings will help reveal research gaps to guide future research.Systematic review registrationPROSPERO CRD42017062403. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2017 Category: International Medicine & Public Health Source Type: research

Prevalence and prognosis of acutely ill patients with organ failure at arrival to hospital: protocol for a systematic review
DiscussionThis review will summarize and analyze studies of prevalence and prognosis of acutely ill patients, with organ failure at arrival to hospital, assist ED physicians assessing the risk of organ failure in unselected patients, and guide recommendations for further research.Systematic review registrationPROSPERO CRD42017060871 (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2017 Category: International Medicine & Public Health Source Type: research

Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol
DiscussionThis systematic review of preclinical evidence will provide a summary of the efficacy and safety of MSCs in animal models of MI. The results will help determine whether sufficient evidence exists to conduct a clinical trial in humans and inform its design. (Source: Systematic Reviews)
Source: Systematic Reviews - November 7, 2017 Category: International Medicine & Public Health Source Type: research

Effectiveness of interventions during NICU hospitalization on the neurodevelopment of preterm infants: a systematic review protocol
DiscussionThe results of this systematic review will highlight which interventions are effective for promoting preterm infants ’ neurodevelopment during NICU hospitalization and will contribute to the body of knowledge in neonatal care by providing guidance for NICU clinical practice and research.Systematic review registrationPROSPEROCRD42017047072 (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2017 Category: International Medicine & Public Health Source Type: research

The role of psychosocial stress in the development of chronic musculoskeletal pain disorders: protocol for a systematic review and meta-analysis
DiscussionTo our knowledge, this review will be the first to systematically explore the available evidence on the aetiological role of psychosocial stress for the development of chronic musculoskeletal pain disorders. This review has the capacity to inform clinical practice on the importance of an early identification and, consequently, treatment of individuals who present with acute musculoskeletal disorders accompanied by a high level of stress.Systematic review registrationPROSPEROCRD42017059949 (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2017 Category: International Medicine & Public Health Source Type: research

Reliability of measurements of the fractured clavicle: a systematic review
ConclusionNo definite conclusions could be drawn. In order to optimize future studies and the realization of comparable results, more research is necessary to identify a standardized method of imaging and measuring.Level of Evidence III. (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2017 Category: International Medicine & Public Health Source Type: research

The macro-economic determinants of health and health inequalities —umbrella review protocol
DiscussionOur umbrella review protocol provides a robust method to systematically appraise the evidence in this field, using new conceptual models derived specifically to address the study question. This will yield important information for policymakers, practitioners and researchers at the local, national and international level. It will also help set the future research agenda in this field and guide the development of interventions.Systematic review registrationThis umbrella review protocol has been registered with PROSPEROCRD42017068357. (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2017 Category: International Medicine & Public Health Source Type: research

Putting research in place: an innovative approach to providing contextualized evidence synthesis for decision makers
ConclusionsBy asking the health system to identify its own priorities and to participate directly in the research process, CHRSP fully integrates KT among researchers and knowledge users in healthcare in Newfoundland and Labrador. This high level of decision-maker buy-in has resulted in a corresponding level of uptake. CHRSP studies have directly informed a number of policy and practice directions, including the design of youth residential treatment centers, a provincial policy on single-use medical devices, and most recently, the opening of the province ’s first Acute Care for the Elderly hospital unit. (Source: Systematic Reviews)
Source: Systematic Reviews - November 2, 2017 Category: International Medicine & Public Health Source Type: research

Methodological quality and transparency of clinical practice guidelines for the pharmacological treatment of non-communicable diseases using the AGREE II instrument: a systematic review protocol
DiscussionThe AGREE II instrument will be applied to evaluate the quality of CPGs and contribute to enhance the discussion and development of guidelines of high quality. The findings will be submitted for publication in high-impact, peer-reviewed scientific journals and will also be disseminated at international conferences.Systematic review registrationPROSPEROCRD42016043364 (Source: Systematic Reviews)
Source: Systematic Reviews - November 2, 2017 Category: International Medicine & Public Health Source Type: research

Family resilience and adaptive coping in children with juvenile idiopathic arthritis: protocol for a systematic review
The objective is to determine which resilience processes are associated with a favourable quality of life in terms of academic, communication, emotional, interpersonal, physical, psychological, and social well-being in families of children with chronic pain associated with JIA.Methods/designThis systematic review will be conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the PRESS (Peer Review of Electronic Search Strategies) guideline.Longitudinal, cross-sectional, and treatment studies written in English will be included, as will grey literature ...
Source: Systematic Reviews - November 2, 2017 Category: International Medicine & Public Health Source Type: research

Mobile tablet-based therapies following stroke: a systematic scoping review protocol of attempted interventions and the challenges encountered
DiscussionTrends in MTBT feasibility and common challenges will be discussed to summarize major findings and highlight research gaps. Solutions to common challenges experienced by intervention participants and study staff will be proposed. Implications for the conduct of randomized clinical trials of MTBT efficacy and the appropriateness of a systematic review and meta-analysis of completed trials will be discussed.Systematic review registrationuO Research (http://hdl.handle.net/10393/35696). (Source: Systematic Reviews)
Source: Systematic Reviews - November 2, 2017 Category: International Medicine & Public Health Source Type: research

Effectiveness of real-time polymerase chain reaction assay for the detection of Mycobacterium tuberculosis in pathological samples: a systematic review and meta-analysis
ConclusionsRT-PCR assay demonstrated a high degree of sensitivity for pulmonary TB and good sensitivity for extra-pulmonary TB. It indicated a high degree of specificity for ruling in TB infection from sampling regimes. This was acceptable, but may better as a rule out add-on diagnostic test. RT-PCR assays demonstrate both a high degree of sensitivity in pulmonary samples and rapidity of detection of TB which is an important factor in achieving effective global control and for patient management in terms of initiating early and appropriate anti-tubercular therapy.Systematic review registrationPROSPEROCRD42015027534. (Sourc...
Source: Systematic Reviews - October 25, 2017 Category: International Medicine & Public Health Source Type: research

Understanding the experience of initiating community-based physical activity and social support by people with serious mental illness: a systematic review using a meta-ethnographic approach
DiscussionThis systematic review is expected to provide new insights into the experience of community-based group physical activity initiation for adults who have a serious mental illness to inform person-centred improvements to the management of serious mental illness through physical activity.Systematic review registrationThe protocol has been registered on the International Prospective Register of Systematic Reviews (PROSPERO) on 22/03/2017; (registration numberCRD42017059948). (Source: Systematic Reviews)
Source: Systematic Reviews - October 25, 2017 Category: International Medicine & Public Health Source Type: research

The relationship between childhood body weight and dental caries experience: an umbrella systematic review protocol
DiscussionThe final umbrella review aims to aggregate the available evidence in order to provide a summary for policymakers and to inform healthcare interventions.Systematic review registrationPROSPEROCRD42016047304 (Source: Systematic Reviews)
Source: Systematic Reviews - October 25, 2017 Category: International Medicine & Public Health Source Type: research

Availability and performance of image/video-based vital signs monitoring methods: a systematic review protocol
DiscussionTo the best of our knowledge, this is the first systematic review of image-based non-contact methods of vital signs monitoring. Synthesis of currently available technology will facilitate future research in this highly topical area.Systematic review registrationPROSPEROCRD42016029167 (Source: Systematic Reviews)
Source: Systematic Reviews - October 25, 2017 Category: International Medicine & Public Health Source Type: research

Diabetes-related information-seeking behaviour: a systematic review
ConclusionThe systematic review provides a valuable overview of available knowledge on the information-seeking behaviour of people with diabetes mellitus, although there are only a few studies. There was a high heterogeneity regarding the research question, design, methods and participants. Although the Internet is often used to seek information, health professionals still play an important role in supporting their patients ’ information-seeking behaviour. Specific needs of people with diabetes must be taken into consideration.Systematic review registrationPROSPEROCRD42016037312 (Source: Systematic Reviews)
Source: Systematic Reviews - October 24, 2017 Category: International Medicine & Public Health Source Type: research

Interventions for acute stroke management in Africa: a systematic review of the evidence
ConclusionEvidence from this review confirms the widespread assertion of low applicability and uptake of evidence-based acute stroke care in LMICs. Despite the limited eligible studies, the overall positive patient outcomes following such interventions demonstrate the applicability and value of evidence-based acute stroke care interventions in Africa. Health policy attention is thus required to ensure widespread applicability of such interventions for improved patients ’ outcomes. The review findings also emphasises the need for further research to unravel the reasons for low uptake.Systematic review registrationPROS...
Source: Systematic Reviews - October 24, 2017 Category: International Medicine & Public Health Source Type: research

Effectiveness of behavioral change techniques employed in eHealth interventions designed to improve glycemic control in persons with poorly controlled type 2 diabetes: a systematic review and meta-analysis protocol
DiscussionThis systematic review is one of the firsts to appraise the effectiveness of eHealth interventions employing BCTs which aimed at improving glycemic control in persons with poorly controlled T2DM. The review will aggregate the effect sizes of BCTs on HbA1c levels. The results may inform future eHealth interventions targeting poorly controlled T2DM populations.Systematic review registrationPROSPERO CRD42016049940 (Source: Systematic Reviews)
Source: Systematic Reviews - October 24, 2017 Category: International Medicine & Public Health Source Type: research

Authors ’ response to comments from Nachman KE et al.
AbstractAuthors ’ response to comments letter to the editor from Nachman KE et al. (Source: Systematic Reviews)
Source: Systematic Reviews - October 23, 2017 Category: International Medicine & Public Health Source Type: research

Use of social network analysis methods to study professional advice and performance among healthcare providers: a systematic review
ConclusionNetwork methods are underutilized for the purposes of understanding professional communication and performance among healthcare providers. The paucity of articles meeting our search criteria, lack of studies in middle- and low-income contexts, limited number in non-tertiary settings, and few longitudinal, experimental designs, or network interventions present clear research gaps.Systematic review registrationPROSPEROCRD42015019328 (Source: Systematic Reviews)
Source: Systematic Reviews - October 23, 2017 Category: International Medicine & Public Health Source Type: research

Exploring the clinically orientated roles of the general practice receptionist: a systematic review protocol
DiscussionThe review will explore existing research covering the clinically orientated roles of the GP receptionist. The findings of the review will be important for healthcare professionals and academics working within primary healthcare. It will highlight and for the first time synthesise research relating to the complex and essential work of the GP receptionist. Our findings will inform the direction and focus of further research, as gaps in the knowledge base will be uncovered.Systematic review registrationPROSPERO registration no:CRD42016048957. (Source: Systematic Reviews)
Source: Systematic Reviews - October 23, 2017 Category: International Medicine & Public Health Source Type: research

A systematic review protocol on the effectiveness of therapeutic exercises utilised by physiotherapists to improve function in patients with burns
DiscussionBurns may have a long-lasting impact on both psychological and physical functioning and thus it is important to identify and evaluate the effects of current and past aerobic and strength exercises on patients with burns. By identifying the characteristics of effective exercise programmes, guidelines can be suggested for developing intervention programmes aimed at improving the function of patients with burns. The safety and precautions of exercise regimes and the optimal frequency, duration, time and intensity will also be examined to inform further intervention.Systematic review registrationPROSPEROCDR4201604837...
Source: Systematic Reviews - October 23, 2017 Category: International Medicine & Public Health Source Type: research

Costs related to cardiac arrest management: a systematic review protocol
DiscussionThis review will provide an estimate of costs related to cardiac arrest management according to the different components of such a management as well as total costs.Systematic review registrationInternational Prospective Register of Systematic Reviews PROSPEROCRD42016046993 (Source: Systematic Reviews)
Source: Systematic Reviews - October 17, 2017 Category: International Medicine & Public Health Source Type: research

SEED: a tool for disseminating systematic review data into Wikipedia
AbstractWikipedia, the free-content online encyclopaedia, contains many heavily accessed pages relating to healthcare. Cochrane systematic reviews contain much high-grade evidence but dissemination into Wikipedia has been slow. New skills are needed to both translate and relocate data from Cochrane reviews to implant into Wikipedia pages. This letter introduces a programme to greatly simplify the process of disseminating the summary of findings of Cochrane reviews into Wikipedia pages. (Source: Systematic Reviews)
Source: Systematic Reviews - October 17, 2017 Category: International Medicine & Public Health Source Type: research

A proposed framework for developing quality assessment tools
ConclusionsWe recommend that anyone who would like to develop a new quality assessment tool follow the stages outlined in this paper. We hope that our proposed framework will increase the number of tools developed using robust methods. (Source: Systematic Reviews)
Source: Systematic Reviews - October 17, 2017 Category: International Medicine & Public Health Source Type: research

Olfactive stimulation interventions for managing procedural pain in preterm and full-term neonates: a systematic review protocol
The objective of this systematic review is to evaluate the effect of olfactive stimulation intervention on the pain response of preterm and full-term neonates during painful procedures.MethodsAn electronic search will be conducted in various databases such as PubMed (1946 to date), MEDLINE (1946 to date), CINAHL (1981 to date), Embase (1947 to date), PsycINFO (1806 to date), Web of Science (1945 to date), CENTRAL and Scopus (1960 to date), and Proquest, without restriction for the year of publication. Only studies published in English or French will be included. The search will be conducted using the following three concep...
Source: Systematic Reviews - October 17, 2017 Category: International Medicine & Public Health Source Type: research

High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis
ConclusionsIn patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to NIV or standard oxygen. Secondary outcomes including dyspnea, tolerance, and safety were not systematically reported. Residual heterogeneity and variable reporting of secondary outcomes limit the conclusions that can be made in this review. Prospective trials designed to evaluate the efficacy and safety of HFNC in patients with acute hypoxemic respiratory failure are required. (Source: Systematic Reviews)
Source: Systematic Reviews - October 16, 2017 Category: International Medicine & Public Health Source Type: research

Ventriculoperitoneal shunt insertion for hydrocephalus in human immunodeficiency virus-infected adults: a systematic review and meta-analysis protocol
This study will generate a comprehensive review of VPS in HIV-infected patients for publication. The primary outcome of meta-analysis is 12-month survival. If only low-quality, heterogeneous studies are available, this study will demonstrate this deficiency and will be of value in justifying and aiding the design of future studies.Systematic review registrationPROSPERO CRD42016052239 (Source: Systematic Reviews)
Source: Systematic Reviews - October 16, 2017 Category: International Medicine & Public Health Source Type: research

Renal manifestations of HIV during the antiretroviral era in South Africa: a systematic scoping review
ConclusionThe findings of the review have implications to the recently adopted ‘test and treat’ approach to HIV prevention and management.Systematic review registrationPROSPEROCRD42016039270 (Source: Systematic Reviews)
Source: Systematic Reviews - October 13, 2017 Category: International Medicine & Public Health Source Type: research

Predictors of multidisciplinary rehabilitation outcomes in patients with chronic musculoskeletal pain: protocol for a systematic review and meta-analysis
This study protocol, therefore, presents our planned systematic review and meta-analysis on important predictive factors for health and work-related outcomes following multidisciplinary rehabilitation (MDR) in patients with chronic musculoskeletal pain.MethodsWe aim to perform a synthesis of the available evidence together with a meta-analysis of published peer-reviewed original research that includes predictive factors preceding MDR. Included are prospective studies of adults with benign, chronic (>  3 months) musculoskeletal pain diagnoses who have taken part in MDR. In the studies, associations between pe...
Source: Systematic Reviews - October 11, 2017 Category: International Medicine & Public Health Source Type: research

Interventions to reduce dependency in bathing in community dwelling older adults: a systematic review
ConclusionDespite evidence suggesting the importance of addressing bathing difficulties as a means of possible prevention of disability in the ageing process, there is a dearth of evaluative or interventional research studies. Further robust research is warranted, including studies of randomised and controlled design. (Source: Systematic Reviews)
Source: Systematic Reviews - October 11, 2017 Category: International Medicine & Public Health Source Type: research

Recommendations for reporting of systematic reviews and meta-analyses of diagnostic test accuracy: a systematic review
ConclusionItems on the methods and reporting of DTA systematic reviews in the present systematic review will provide a basis for generating a PRISMA extension for DTA systematic reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - October 10, 2017 Category: International Medicine & Public Health Source Type: research

Herceptin ® (trastuzumab) in HER2-positive early breast cancer: protocol for a systematic review and cumulative network meta-analysis
This study will evaluate survival trends associated with originator trastuzumab in patients with HER2+ early breast cancer. As originator trastuzumab has been researched in both clinical and real-world settings for close to 20  years, a cumulative NMA is likely to show improved precision around the parameter estimates for trastuzumab now compared with when the drug was initially launched in the USA in 1998. A better understanding of the evolution of publicly available comparative evidence for originator trastuzumab wi ll further inform treatment for patients with HER2+ early breast cancer, providin...
Source: Systematic Reviews - October 10, 2017 Category: International Medicine & Public Health Source Type: research

Effect of intra-pregnancy nonsurgical periodontal therapy on inflammatory biomarkers and adverse pregnancy outcomes: a systematic review with meta-analysis
ConclusionsThese results demonstrated that the intra-pregnancy nonsurgical periodontal therapy decreased periodontal inflammatory biomarker levels from gingival crevicular fluid and some from serum blood, with no influence on inflammatory biomarker level from cord blood, and it did not consistently reduce adverse gestational adverse outcome occurrence.Systematic review registrationPROSPEROCRD42015027750 (Source: Systematic Reviews)
Source: Systematic Reviews - October 10, 2017 Category: International Medicine & Public Health Source Type: research

Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980 –2016
DiscussionOur systematic review and meta-analysis aims to contribute to an improved understanding of global epidemiologic patterns of syphilis infection in most-at-risk populations. Through systematic classification of the existing literature, and comparison of disease patterns across regional, temporal and socio-behavioral differences, we hope to improve public health surveillance and improve efforts to control the spread of disease across the Americas.Systematic review registrationPROSPERO CRD42016047306. (Source: Systematic Reviews)
Source: Systematic Reviews - October 10, 2017 Category: International Medicine & Public Health Source Type: research

Identifying effective components for mobile health behaviour change interventions for smoking cessation and service uptake: protocol of a systematic review and planned meta-analysis
DiscussionThe results of this systematic review will provide future research with a foundation for designing and evaluating complex interventions that use mobile phones as a platform to deliver behaviour change techniques.Systematic review registrationPROSPEROCRD42016026918. (Source: Systematic Reviews)
Source: Systematic Reviews - October 6, 2017 Category: International Medicine & Public Health Source Type: research

Prevalence, awareness, and associated risk factors of hypertension in older adults in Africa: a systematic review and meta-analysis protocol
DiscussionThe estimates of the prevalence, the risk factors and the level of awareness of hypertension could help in galvanizing efforts at prioritizing the cardiovascular health of older persons in Africa.Systematic review registrationPROSPEROCRD42017056474 (Source: Systematic Reviews)
Source: Systematic Reviews - October 4, 2017 Category: International Medicine & Public Health Source Type: research

Role of bispectral index monitoring and burst suppression in prognostication following out-of-hospital cardiac arrest: a systematic review protocol
DiscussionThis review will synthesize the evidence on the use of BIS monitors within 24  h of achieving return of spontaneous circulation (ROSC) and may help in early prognostication.Systematic review registrationPROSPERO CRD42016050224. (Source: Systematic Reviews)
Source: Systematic Reviews - September 25, 2017 Category: International Medicine & Public Health Source Type: research

The effect of psychological interventions on the prevention of chronic pain in adults: a systematic review protocol
DiscussionThis systematic review is the first in examining the effects of psychological interventions implemented in the acute pain phase with the objective of preventing chronic pain. Results of this systematic review could provide information on psychological intervention characteristics that are most helpful for individuals with pain and guidance as to when such interventions should be applied in the continuum of care.Systematic review registrationPROSPERO CRD42016049312 (Source: Systematic Reviews)
Source: Systematic Reviews - September 21, 2017 Category: International Medicine & Public Health Source Type: research

Risk of mortality among children, adolescents, and adults with autism spectrum disorder or attention deficit hyperactivity disorder and their first-degree relatives: a protocol for a systematic review and meta-analysis of observational studies
DiscussionOur study will establish the extent of the epidemiological evidence underlying the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. We anticipate that our findings will be of interest to patients, their families, caregivers, healthcare professionals, scientists, and policy makers. Implications for future epidemiological research will be discussed.Systematic review registrationPROSPEROCRD42017059955. (Source: Systematic Reviews)
Source: Systematic Reviews - September 15, 2017 Category: International Medicine & Public Health Source Type: research

The validity and reliability of the four square step test in different adult populations: a systematic review
ConclusionsThe FSST may be an effective and valid tool for measuring dynamic balance and a participants ’ falls risk. It has been shown to have strong correlations with other measures of balance and mobility with good reliability shown in a number of populations. However, the quality of the papers reviewed was variable with key factors, such as sample size and test set up, needing to be addressed be fore the tool can be confidently used in these specified populations. (Source: Systematic Reviews)
Source: Systematic Reviews - September 11, 2017 Category: International Medicine & Public Health Source Type: research

Interventions to control myopia progression in children: protocol for an overview of systematic reviews and meta-analyses
DiscussionThis overview will examine the high level of existing evidence for treatment of myopia progression. Efficient interventions will be identified, and side effects will be reported. The expected benefit is that all robust recent research evidence will be compiled in a single study. The results may inform future research in this area, which should provide insight into the appropriate regimes for the administration of these modalities and contribute to future guideline development.Systematic review registrationPROSPEROCRD42017068204 (Source: Systematic Reviews)
Source: Systematic Reviews - September 11, 2017 Category: International Medicine & Public Health Source Type: research

Sex and gender considerations in transplantation research: protocol for a scoping review
DiscussionThis scoping review will be an important stepping stone towards the development of good practice guidelines on study design and analysis considerations when handling sex and gender issues in human transplantation research. This scoping review can also help identify methodological issues that restrict the translation of transplantation research findings into clinical practice related to underestimation of sex/gender differences. This review will ultimately identify major gaps, inform donor-recipient selection, guide personalized interventions, and prioritize research recommendations in human transplantation resear...
Source: Systematic Reviews - September 8, 2017 Category: International Medicine & Public Health Source Type: research

Overviews of systematic reviews: great promise, greater challenge
AbstractThe proliferation of systematic reviews and escalating demand from policy makers has driven a newer form of evidence synthesis —overviews of systematic reviews.Systematic Reviews are publishing a special thematic series on overviews and are encouraging submissions on the development and evaluation of methods for this review type. The authors ’ of this editorial introduce the series by considering challenges that arise when conducting an overview and what methods guidance is available. They emphasise the importance of evaluating overview methods to understand the trade-offs of using different approaches ...
Source: Systematic Reviews - September 8, 2017 Category: International Medicine & Public Health Source Type: research

Comparative safety and efficacy of pharmacological and non-pharmacological interventions for the behavioral and psychological symptoms of dementia: protocol for a systematic review and network meta-analysis
DiscussionWe will identify the safest and most efficacious treatment strategies for patients with BPSD from among our most highly ranked treatments. The results of this study will be used to guide decision-making and improve patient care.Systematic review registrationPROSPERO registry number CRD42017050130. (Source: Systematic Reviews)
Source: Systematic Reviews - September 7, 2017 Category: International Medicine & Public Health Source Type: research

Strategies to improve the quality of life of persons post-stroke: protocol of a systematic review
DiscussionThis systematic review will identify those quality improvement strategies aimed at the health system, health care professionals, and patients that impact the quality of life of individuals with stroke. Improving awareness and utilization of such strategies may enhance uptake of stroke best practices and reduce inappropriate health care utilization costs.Systematic review registrationPROSPERO,CRD42017064141 (Source: Systematic Reviews)
Source: Systematic Reviews - September 7, 2017 Category: International Medicine & Public Health Source Type: research

Social determinants of common metabolic risk factors (high blood pressure, high blood sugar, high body mass index and high waist-hip ratio) of major non-communicable diseases in South Asia region: a systematic review protocol
This study will identify social determinants of common metabolic risk factors of major non-communicable diseases in the context of the South Asian region and map their causal pathway.MethodsA systematic review of selected articles will be carried out following Cochrane guidelines. Review will be guided by Social Determinants of Health Framework developed by the World Health Organization to extract social determinants of metabolic risk factors of non-communicable diseases from studies. A distinct search strategy will be applied using key words to screen relevant studies from online databases. Primary and grey literature pub...
Source: Systematic Reviews - September 7, 2017 Category: International Medicine & Public Health Source Type: research

Evaluative reports on medical malpractice policies in obstetrics: a rapid scoping review
ConclusionsOnly a few litigation policies in obstetrics were evaluated or compared. Included documents showed that initiatives to reduce medical malpractice litigation could be associated with a decrease in adverse and malpractice events. However, due to heterogeneous settings (e.g., economic structure, healthcare system) and variation in the outcomes reported, the advantages and disadvantages of initiatives may vary. (Source: Systematic Reviews)
Source: Systematic Reviews - September 6, 2017 Category: International Medicine & Public Health Source Type: research

Socio-ecological influences on adolescent (aged 10 –17) alcohol use and linked unhealthy eating behaviours: protocol for a systematic review and synthesis of qualitative studies
DiscussionThis synthesis will interpret individual studies by identification of second-order constructs (interpretations offered by the original researchers) and third-order constructs (development of new interpretations beyond those offered in individual studies) by way of the development of a ‘model structure’ of shared influences upon both unhealthy eating behaviours and alcohol use. It is anticipated that this ‘model structure’ will aid subsequent co-design and piloting of a future intervention to help reduce health risk and social inequalities due to excess weight gain and alc ohol consumption....
Source: Systematic Reviews - September 2, 2017 Category: International Medicine & Public Health Source Type: research