Protocol for a systematic review and meta-analysis of research on the associations between workplace bullying and sleep
DiscussionThis review and meta-analysis will be among the first to systematically explore and integrate the evidence available on the association between exposure to bullying and sleep, as well as on the mediating and moderating factors that can govern this associations. By gathering and summarizing information about potential factors that can explain when and how bullying is related to sleep, the findings from this study will provide directions for future research and provide practitioners and clinicians with an understanding about the nature and consequences of workplace bullying and point to directions for relevant inte...
Source: Systematic Reviews - December 13, 2018 Category: International Medicine & Public Health Source Type: research

Interventions for behaviour change and self-management in stroke secondary prevention: protocol for an overview of reviews.
DiscussionThis overview will comprehensively bring together the best available evidence supporting person-centred, stroke secondary prevention strategies in an accessible format, identifying current knowledge gaps. (Source: Systematic Reviews)
Source: Systematic Reviews - December 13, 2018 Category: International Medicine & Public Health Source Type: research

Current state and future directions of technology-based ecological momentary assessments and interventions for major depressive disorder: protocol for a systematic review
The objective of this systematic review is to provide the state of the art of technology-based EMAs and EMIs for major depressive disorder (MDD), with the aim of leading the way to possible future directions for the clinical practice.MethodsWe will conduct a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Data sources will include two bibliographic databases, PubMed and Web of Science (Web of Knowledge), supplemented by searches for unpublished or ongoing studies. Eligible studies will report data for adult ( ≥ 18 years old) with a primary...
Source: Systematic Reviews - December 13, 2018 Category: International Medicine & Public Health Source Type: research

Resting blood pressure reductions following handgrip exercise training and the impact of age and sex: a systematic review and narrative synthesis
ConclusionsHandgrip exercise is an effective modality for resting BP reduction resulting in clinically significant reductions for men and women of all ages.Systematic review registrationPROSPEROCRD42015019792 (Source: Systematic Reviews)
Source: Systematic Reviews - December 12, 2018 Category: International Medicine & Public Health Source Type: research

A systematic review of the risk factors for suicidal ideation, suicidal attempt and completed suicide among children and adolescents in sub-Saharan Africa between 1986 and 2018: protocol for a systematic review of observational studies
DiscussionThis protocol describes a systematic review of observational studies reporting completed suicide, suicidal ideation and suicidal attempt among children and adolescents in sub-Saharan Africa. We anticipate that once this review is complete and published, our findings will be of interest to adolescents with suicidal behaviour, their families and caregivers, clinicians and other healthcare professionals, scientists and policy makers.Systematic review registrationPROSPERO International prospective register of systematic reviews:CRD42016048610. (Source: Systematic Reviews)
Source: Systematic Reviews - December 12, 2018 Category: International Medicine & Public Health Source Type: research

Angioplasty and stenting for below the knee ulcers in diabetic patients: protocol for a systematic review
DiscussionWhile there are several available endovascular techniques for revascularisation, it is unclear which technique has better outcomes for ulcers below the knee in diabetic patients. A systematic review is required to validate and demonstrate these techniques and their outcomes to allow an evidence-based clinical decision.Systematic review registrationPROSPEROCRD42017065171 (Source: Systematic Reviews)
Source: Systematic Reviews - December 11, 2018 Category: International Medicine & Public Health Source Type: research

Interventions integrating health and academic interventions to prevent substance use and violence: a systematic review and synthesis of process evaluations
ConclusionSeveral useful facilitating and inhibiting factors linked to the implementation of interventions that integrate academic and health education for reduced substance use and/or violence were identified, providing tentative but insightful evidence of context-specific issues that may impact intervention success. However, overall, there is still a considerable gap in our understanding of how to achieve the successful implementation of these interventions. (Source: Systematic Reviews)
Source: Systematic Reviews - December 6, 2018 Category: International Medicine & Public Health Source Type: research

Defining and conceptualising data harmonisation: a scoping review protocol
DiscussionWe list potential limitations of this scoping review. To our knowledge, this scoping review will be the first to synthesise definitions and conceptualisations of data harmonisation in the literature as well as the underlying explanations in the literature of the causal links between data harmonisation and health management decision-making. (Source: Systematic Reviews)
Source: Systematic Reviews - December 6, 2018 Category: International Medicine & Public Health Source Type: research

Diagnostic accuracy of molecular methods for detecting markers of antimalarial drug resistance in clinical samples of Plasmodium falciparum : protocol for an update to a systematic review and meta-analysis
The objective of this update to this systematic review is to improve and update identification of the sensitivity and specificity of each molecular method for detecting selected antimalarial drug resistance markers.MethodsWe will include diagnostic accuracy studies that compare at least two of any molecular methods to examine blood samples from patients diagnosed with, or suspected of having malaria, to detect at least one selected marker of antimalarial drug resistance. We will search PubMed, EMBASE, BIOSIS, and Web of Science from 2000 to present. Two reviewers will independently screen all results, extract data, conside...
Source: Systematic Reviews - December 5, 2018 Category: International Medicine & Public Health Source Type: research

Bioactive scaffolds in stem-cell-based therapies for cardiac repair: protocol for a meta-analysis of randomized controlled preclinical trials in animal myocardial infarction models
DiscussionTo date, the use of scaffolds in myocardial repair has not yet been systematically reviewed. The results of this meta-analysis will aid in determining the efficacy of stem cell-embedded scaffolds for cardiac repair and help bring this therapy to the clinic. (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2018 Category: International Medicine & Public Health Source Type: research

The effect of depression management on diabetes and hypertension outcomes in low- and middle-income countries: a systematic review protocol
DiscussionThe findings from this review will provide evidence to be used in guiding practice and policy on how to integrate depression management in diabetes and hypertension clinics.Systematic review registrationPROSPEROCRD42017068257 (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2018 Category: International Medicine & Public Health Source Type: research

Altered pain processing in people with type I and II diabetes: a protocol for a systematic review and meta-analysis of pain threshold and pain modulation mechanisms
DiscussionThis systematic review and meta-analysis will summarise the evidence on pain threshold profiles and pain modulation mechanisms in people with diabetes without and with neuropathies (both painful and non-painful). This will provide more insight in the clinical presentation and progression of diabetic neuropathies.Systematic review registrationPROSPEROCRD42018088173 (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2018 Category: International Medicine & Public Health Source Type: research

Professional learning and development of postdoctoral scholars: a scoping review protocol
DiscussionDespite the growing numbers of postdoctoral scholars, there has been no synthesis of the sources of evidence of postdoctoral scholars ’ professional learning and development. In reviewing a wide range of evidence and integrating it into a manageable and meaningful whole, this scoping review will be a critical first step in understanding the professional learning and development of postdoctoral scholars. Our results will help inf orm future research and the development of a framework for postdoctoral scholar’s professional learning and development. (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2018 Category: International Medicine & Public Health Source Type: research

HIV-related data among key populations to inform evidence-based responses: protocol of a systematic review
DiscussionFindings from this systematic review and the development of the enhanced graphical interface to display data, along with ongoing efforts to build capacity among key stakeholders to better use and interpret available data, will help ensure that available epidemiologic data related to key populations can be appropriately used to guide large-scale HIV funding and programmatic responses.Systematic review registrationPROPSEROCRD42016047259. (Source: Systematic Reviews)
Source: Systematic Reviews - December 3, 2018 Category: International Medicine & Public Health Source Type: research

Screening for small for gestational age using third-trimester ultrasound markers: protocol for a systematic review and meta-analysis of screening test accuracy
DiscussionThis systematic review will determine the relevance of routine third-trimester ultrasound markers in the screening for FGR in low-risk or general population and their usefulness in standard pregnancy care. Additionally, this knowledge synthesis represents a step in the optimization of the discriminative ability of third-trimester ultrasound and predictive tools, allowing for targeted interventions aiming at the reduction of FGR complications and ultimately improving infants ’ health.Systematic review registrationThis protocol has been registered at PROSPERO: international prospective register of systematic ...
Source: Systematic Reviews - December 3, 2018 Category: International Medicine & Public Health Source Type: research

A review protocol on research partnerships: a Coordinated Multicenter Team approach
DiscussionComprehensively describing and differentiating research partnership terminology and its domains will address well-documented gaps in the literature. These efforts will contribute to and improve the quality, conduct, and reporting of research partnership literature. The collaborative review methodology will help identify and establish common terms, leverage efficiencies (e.g., expertise, experience, search and protocol design, resources) and optimize research feasibility and quality. Our approach allows for enhanced scope and inclusivity of all research user groups and domains, thereby contributing uniquely to the...
Source: Systematic Reviews - November 30, 2018 Category: International Medicine & Public Health Source Type: research

Anesthesia interventions that alter perioperative mortality: a scoping review
ConclusionsBy mapping intervention themes, this scoping review has identified areas requiring further systematic investigation given their potential value for reducing patient mortality as well as areas where continued investment may not be cost-effective given limited evidence for improving survival. This is a key starting point for future knowledge translation to optimize anesthesia practice. (Source: Systematic Reviews)
Source: Systematic Reviews - November 30, 2018 Category: International Medicine & Public Health Source Type: research

The effectiveness of interventions to reduce peripheral blood culture contamination in acute care: a systematic review protocol
DiscussionThis review will identify and summarise the interventions previously described in the literature aimed at reducing peripherally collected blood culture contamination rates in acute care. These findings have the potential to lead to multifaceted interventions based on previous evidence to reduce blood culture contamination in the acute setting. Reductions in the proportion of contaminated blood cultures have the potential to save money, unrequired treatment (particularly antimicrobials) and hospital bed days.Systematic review registrationIn accordance with guidelines outlined in the PRISMA-P methodology, this prot...
Source: Systematic Reviews - November 30, 2018 Category: International Medicine & Public Health Source Type: research

The effectiveness of patient-centred medical home model versus standard primary care in chronic disease management: protocol for a systematic review and meta-analysis of randomised and non-randomised controlled trials
DiscussionThe findings of the proposed systematic review will provide the highest level of evidence to date on the effectiveness of the PCMH model versus standard primary care in chronic disease management. We believe that our findings will inform patients, primary care providers, and public health administrators and policy-makers on the benefits and risks of PCMH model of care.Systematic review registrationPROSPERO CRD42018085378 (Source: Systematic Reviews)
Source: Systematic Reviews - November 29, 2018 Category: International Medicine & Public Health Source Type: research

Quantified patient preferences for lifestyle intervention programs for diabetes prevention — a protocol for a systematic review
DiscussionThe proposed systematic review will provide an overview of the methods used and current practice in the elicitation and quantification of patients ’ preferences for diabetes prevention lifestyle interventions. Furthermore, the methodological quality of the identified studies will be appraised as well.Systematic review registrationPROSPEROCRD42018086988 (Source: Systematic Reviews)
Source: Systematic Reviews - November 29, 2018 Category: International Medicine & Public Health Source Type: research

Short-acting bronchodilators for the management of acute exacerbations of chronic obstructive pulmonary disease in the hospital setting: systematic review
AbstractBackgroundCurrently, there is a lack of guidelines for the use of short-acting bronchodilators (SABD) in people admitted to hospital for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), despite routine use in practice and risk of cardiac adverse events.AimTo review the evidence that underpins use and optimal dose, in terms of risk versus benefit, of SABD for inpatient management of AECOPD and collate the results for future guidelines.MethodsMedline, Embase, the Cochrane Central Register of Controlled Trials,clinicaltrials.gov and International Clinical Trials Registry Platform were searched (in...
Source: Systematic Reviews - November 29, 2018 Category: International Medicine & Public Health Source Type: research

Barriers and facilitators to the integration of mental health services into primary health care: a systematic review
The objective of the review was to synthesize evidence of barriers and facilitators to the integration of mental health services into PHC from existing literature. The structure of the review was guided by the SPIDER framework which involves the following:Sample or population of interest —primary care providers (PCPs);Phenomenon of Interest—integration of mental health services into primary health care (PHC);Design—influenced robustness and analysis of the study;Evaluation—outcomes included subjective outcomes (views and attitudes); andResearch type—qualitative, quantitative, and mixed methods...
Source: Systematic Reviews - November 28, 2018 Category: International Medicine & Public Health Source Type: research

Factors associated with preoperative attrition in bariatric surgery: a protocol for a systematic review
DiscussionPresently, there are studies and reviews investigating population-based utilisation and access to bariatric surgery; however, there is a need to review the reasons behind preoperative bariatric surgery patient attrition once selected for bariatric surgery. The results of the review will highlight potential systematic disparities in patient attrition, where gaps in knowledge remain for further investigation, and suggest areas where countermeasures may be focussed for decreasing attrition rates.Systematic review registrationPROSPEROCRD42017068557 (Source: Systematic Reviews)
Source: Systematic Reviews - November 28, 2018 Category: International Medicine & Public Health Source Type: research

Effectiveness of pharmacotherapy for smoking cessation: protocol for umbrella review and quality assessment of systematic reviews
DiscussionThe World Health Organization recommends treatment of tobacco dependence as one approach in its comprehensive tobacco control policy. To date, many trials and systematic reviews have been conducted to assess the effectiveness of pharmacotherapy for smoking cessation. Therefore, the findings of the umbrella review will improve clinical decision-making and be used as a baseline for future studies.Systematic review registrationPROSPERO CRD42017080906 (Source: Systematic Reviews)
Source: Systematic Reviews - November 24, 2018 Category: International Medicine & Public Health Source Type: research

Stakeholder involvement in systematic reviews: a scoping review
Discussion/conclusionWe identified a relatively large number (291) of papers reporting stakeholder involvement in systematic reviews, but the quality of reporting was generally very poor. Information from a subset of papers judged to provide the best descriptions of stakeholder involvement in systematic reviews provide examples of different ways in which stakeholders have been involved in systematic reviews. These examples arguably currently provide the best available information to inform and guide decisions around the planning of stakeholder involvement within future systematic reviews. This evidence has been used to dev...
Source: Systematic Reviews - November 24, 2018 Category: International Medicine & Public Health Source Type: research

Is increased carer knowledge of the health care system associated with decreased preventable hospitalizations for people in the community diagnosed with dementia? A systematic review protocol
This study aims to assess the effectiveness of interventions focused on reducing avoidable hospitalization for PLWD by supporting carers to manage the health care needs of the PLWD, via improved awareness and understanding of health and the healthcare system.MethodScientific and gray literature will be searched using a combination of keywords pertaining to dementia, caregivers, education, and support. Included studies will involve community-dwelling PLWD and caregivers, with interventions aimed at improving carer ’s understanding of the healthcare system and ability to manage the caregiving role. The primary outcome ...
Source: Systematic Reviews - November 24, 2018 Category: International Medicine & Public Health Source Type: research

The relationship between a trusted adult and adolescent outcomes: a protocol of a scoping review
This study is a scoping review. A broad range of databases will be searched, including MEDLINE, ERIC, Education Abstracts, Web of Science, ASSIA, Sociological Abstracts, and PsycINFO. Predefined inclusion/exclusion criteria will be used, with a focus on outcomes relating to health and education. Two reviewers will blind screen papers independently at all screening stages, with conflicts being resolved by a third reviewer. Quantitative and qualitative studies, as well as unpublished (grey) literature/reports, will be included. We will use the World Health Organization ’s ‘second decade’ definition of adole...
Source: Systematic Reviews - November 24, 2018 Category: International Medicine & Public Health Source Type: research

Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders: a protocol for a systematic review
The objective of the current protocol is to provide the methodology for a systematic review regarding the effects of Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders.MethodThis protocol was developed according to the Preferred Reporting Items for Systematic reviews and Meta-analyses for Protocols (PRISMA-P) 2015 guidelines. Electronic database searches will include EBSCOhost, PubMed and Cochrane Central Register performed by two researchers. This will be complemented by searching other resources such as the reference lists for included studies to identify studies meeting the elig...
Source: Systematic Reviews - November 23, 2018 Category: International Medicine & Public Health Source Type: research

The safety and efficacy of on-site paramedic and allied health treatment interventions targeting the reduction of emergency department visits by long-term care patients: systematic review protocol
DiscussionAs pressure on the healthcare system continues to rise, many areas are looking for alternative models of care. Several programs have been put in place in long-term care centers that seek to avoid transportation to the emergency department by providing enhanced care on-site. These programs are quite variable, and, to date, there is no standardized program or model of care.Systematic review registrationPROSPERO (CRD42018091636) (Source: Systematic Reviews)
Source: Systematic Reviews - November 23, 2018 Category: International Medicine & Public Health Source Type: research

Integrated models of care for diabetes and hypertension in low- and middle-income countries (LMICs)  : Protocol for a systematic review
DiscussionIn light of limited evidence on the provision of comprehensive care for diabetes and hypertension, and its comorbidity in LMCIs, we believe that the findings of this systematic review will provide a synthesis of evidence on effective models of integrated care for diabetes and hypertension and their comorbidities at primary healthcare level. This will enable policy-makers to device policies and programs that are evidence informed.Systematic review registrationPROSPEROCRD42018099314. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis
ConclusionsGenerally, we identified that coverage of the association between SNPs ofCYP genes and anti-tuberculosis drug-related toxicity outcomes is incomplete. We observed significant associations between theRsaI and 96-bp deletion-insertion SNPs of theCYP2E1 gene and anti-tuberculosis drug-related hepatotoxicity. We were unable to comment on the impact of ethnicity on the investigated associations, as information on participants ’ ethnicity was sparsely reported in the included studies.Systematic review registrationPROSPERO registration number: CRD42017068448. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

The impact of musculoskeletal injuries sustained in road traffic crashes on work-related outcomes: a protocol for a systematic review
DiscussionThe results of this systematic review may increase our knowledge of work-related outcomes and understanding of the associated factors for people with musculoskeletal injuries following road traffic crashes. Future studies could use the results to plan interventions and influence policy and legislation, and raise awareness of the needs of this clinical population.Systematic review registrationRegistered on PROSPERO, reference numberCRD42018099252, dated 14 August 2018. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

Mapping evidence on decision-making on contraceptive use among adolescents: a scoping review protocol
DiscussionUnderstanding how adolescents make decisions about whether or not to use contraception is essential for improving contraceptive prevalence rates in this special population. It is envisioned that the results from this review will highlight key evidence on how adolescent make decisions regarding contraceptive use as well as gaps and opportunities for future research. It will also be important in enhancing and re-focusing adolescent sexual and reproductive health policies and programmes. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

Searching Embase and MEDLINE by using only major descriptors or title and abstract fields: a prospective exploratory study
ConclusionsOf the four search options, two options substantially reduced the overall search yield. However, this also resulted in a greater chance of losing relevant references, even though many references were still found in other databases such as Web of Science. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

Prevention of cervical cancer in HIV-seropositive women from developing countries through cervical cancer screening: a systematic review
ConclusionAlthough cervical cancer screening exists in almost all developing countries, what is missing is both opportunistic and systematic organised population-based screenings. Cervical cancer screening programmes need to be integrated into already existing HIV services to enable early detection and treatment. There is a need to offer opportunistic and coordinated screening programmes that are provider-initiated to promote early identification of cervical precancerous lesions.Systematic review registrationPROSPEROCRD42018095702 (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

Time-to-update of systematic reviews relative to the availability of new evidence
ConclusionA minority of 2010 Cochrane reviews were updated before June 2017 to incorporate evidence from new primary studies, and very few updates led to a change in conclusion. We did not find clear evidence that updates were undertaken faster when new evidence was made available. New approaches for finding early signals that a systematic review conclusion is at risk of change may be useful in allocated resources to the updating of systematic reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

Use of indices to measure socio-economic status (SES) in South-Asian urban health studies: a scoping review
ConclusionThis scoping review identifies asset-based wealth index as the most frequently used indices for measuring socioeconomic status in South Asian urban health studies. This review also provides a clear idea about the use of other indices for the measurement SES in the region. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

The effect of rehabilitation interventions on physical function and immobility-related complications in severe stroke —protocol for a systematic review
DiscussionThe results of this systematic review will summarise the strength of evidence for rehabilitation interventions used in the rehabilitation of physical function and immobility-related complications in severe stroke and identify gaps in evidence.Systematic review registrationThe systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) —registration numberCRD77737. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

K13-propeller gene polymorphisms in Plasmodium falciparum parasite population: a systematic review protocol of burden and associated factors
This study will collate evidence from previous studies on the commonly reported K13 -gene polymorphisms amongP. falciparum parasites in malaria-affected countries.Systematic review registrationPROSPERO CRD 42018084624 (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

The quality of clinical practice guidelines for management of pediatric type 2 diabetes mellitus: a systematic review using the AGREE II instrument
ConclusionsOverall, two thirds of the pediatric T2DM guidelines were moderate to low quality and the remaining third ranked higher in quality. Low quality was especially due to the scores for the “Rigour of Development” domain, which directly measures guideline development methodology. It is important that future guidelines and updates of existing guidelines improve the methodology of development and quality of reporting in order to appropriately guide physicians managing children and ad olescents with T2DM.Systematic review registrationPROSPEROCRD42016034187 (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2018 Category: International Medicine & Public Health Source Type: research

Can automated content analysis be used to assess and improve the use of evidence in mental health policy? A systematic review
ConclusionsAutomated content analysis may be useful in assessing and improving the use of evidence in mental health policies. Wordscores is an automated content analysis option for comparing policy and research texts that could be used by both researchers and policymakers. (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2018 Category: International Medicine & Public Health Source Type: research

Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol
DiscussionThis systematic review and meta-analysis will investigate both safety and efficacy ofM. charantia preparations in type 2 diabetes mellitus. The review results will be published in a peer-reviewed journal. The results will bring better understanding of clinical outcomes in treatment of type 2 diabetes mellitus patients and highlight gaps for future research.Systematic review registrationPROSPEROCRD42018083653. (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2018 Category: International Medicine & Public Health Source Type: research

Herceptin ® (trastuzumab) in HER2-positive early breast cancer: a systematic review and cumulative network meta-analysis
ConclusionThis analysis represents the most comprehensive SLR/cNMA to date of published OS data in HER2+ EBC studies. These findings demonstrate why H/chemotherapy is now the established standard of care in HER2+ EBC. In the case of H, the benefits of early patient access far outweighed the risk of waiting for more precise information.Systematic review registrationPROSPEROCRD42017055763 (Source: Systematic Reviews)
Source: Systematic Reviews - November 14, 2018 Category: International Medicine & Public Health Source Type: research

Healthcare provider knowledge, attitudes, beliefs, and practices surrounding the prescription of opioids for chronic non-cancer pain in North America: protocol for a mixed-method systematic review
DiscussionThe ultimate goal of this work is to support interventions aiming to optimize opioid prescribing practices in order to prevent opioid-related morbidity and mortality without restricting a HCP ’s ability to select the most appropriate treatment for an individual patient.Systematic review registrationPROSPEROCRD42018091640. (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Barriers to access and utilization of emergency obstetric care at health facilities in sub-Saharan Africa: a systematic review of literature
ConclusionsA number of factors were found to hamper access to and utilization of emergency obstetric care among women in sub-Saharan Africa. These barriers are inter-dependent and occurred at multiple levels either at home, on the way to health facilities, or at the facilities. Therefore, country-specific holistic strategies including improvements to healthcare systems and the socio-economic status of women need to be strengthened. Further research should focus on the assessment of the third delay, as little is known about facility-readiness.Systematic review registrationPROSPERO CRD42017074102 (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

A systematic review and synthesis of theories of change of school-based interventions integrating health and academic education as a novel means of preventing violence and substance use among students
ConclusionsEroding ‘boundaries’ between health and academic education, teachers and students, classrooms and the wider school and schools and families were seen to be the most critical to establishing new frameworks of family, classroom or school organisation that are conducive to promoting both academic and socia l-emotional outcomes. Whether such interventions are feasible to implement and effective in reducing risk behaviours will be examined in other reports arising from the review. (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of venous coupler devices versus hand-sewn anastomosis for microsurgical free flap reconstruction
DiscussionThere has been no comparison of coupled and hand-sewn venous anastomoses using a robust and validated methodology preceded by a protocol and performing meta-analysis. Included studies are expected to be mainly observational and prone to bias; however, there is value in summarising the evidence, assessing its risk of bias and performing meta-analysis to guide clinicians. By using a broad approach including all types of flaps, we foresee inherent differences regarding the unit of analysis and different anatomic sites. This will limit the validity of our conclusions but is unavoidable. We will seek unpublished data ...
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Relationship between volume and outcome for congenital diaphragmatic hernia: a systematic review protocol
DiscussionGiven the lack of a comprehensive summary of findings on the relationship between hospital or surgeon volume and outcomes for congenital diaphragmatic hernia, this systematic review will put things right. Results can be used to inform decision makers or clinicians and to adapt medical care.Systematic review registrationPROSPERO (CRD42018090231) (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

What influences women ’s movement and the use of different positions during labour and birth: a systematic review protocol
DiscussionThe findings of this review will allow researchers, practitioners and policy makers to better understand the factors influencing women ’s movement and the use of different positions during labour and birth. This will inform future research and the development of maternity services designed to implement best-evidence concerning movement and positioning during labour and birth into clinical practice.Systematic review registrationIn accordance with the PRISMA-P guidelines (Moher et al. Syst Rev 4:1, 2015), the systematic review protocol was registered with the International Prospective Register of Systematic r...
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Systematic review of the surgical management of rotator cuff repair with an augmentative patch: a feasibility study protocol
DiscussionThis review aims to collate the current evidence base regarding the use of patches to augment rotator cuff repair. The results of this review will help to develop, using consensus methods, the design of a definitive randomised trial assessing the clinical and cost-effectiveness of a patch to augment surgical repair of the rotator cuff that is both acceptable to stakeholders and is feasible.Systematic review registrationCRD42017057908 (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research