Comparative effectiveness of physical activity interventions and anti-hypertensive pharmacological interventions in reducing blood pressure in people with hypertension: protocol for a systematic review and network meta-analysis
This study will provide evidence regarding the comparability of two common first-line treatment options for people with hypertension. It will also describe the extent to which there is direct evidence regarding the comparative effectiveness of increasing physical activity and initiating anti-hypertensive therapy.Systematic review registrationPROSPEROCRD42017070579 (Source: Systematic Reviews)
Source: Systematic Reviews - August 21, 2018 Category: International Medicine & Public Health Source Type: research

Resilience to climate-induced disasters and its overall impact on well-being in Southern Africa: a mixed-methods systematic review protocol
DiscussionThis protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. The protocol gives insight of the scope and parameters for the systematic review to be carried out. The systematic review will establish how resilience to climate-induced disasters affects well-being. It will also provide recommendations to improve humanitarian coordination in Southern Africa.Systematic review registrationThe protocol was registered by the PROSPERO international prospective register of systematic reviews, referenceCRD42017064396. (Source: Systematic Reviews)
Source: Systematic Reviews - August 21, 2018 Category: International Medicine & Public Health Source Type: research

Interprofessional collaboration and patient-reported outcomes in inpatient care: protocol for a systematic review
DiscussionThe systematic review will synthesize the evidence regarding the effectiveness of IPC and how it is perceived by patients in inpatient care. As the patients ’ perspective becomes increasingly relevant in the context of quality improvement, the results can help decision-makers in policy- and health care institutions to understand and develop strategies to ensure a high quality of care.Systematic review registrationPROSPERO registration number:CRD42017073900; date of registration in PROSPERO 07 August 2017. (Source: Systematic Reviews)
Source: Systematic Reviews - August 21, 2018 Category: International Medicine & Public Health Source Type: research

The potential of computerised analysis of bowel sounds for diagnosis of gastrointestinal conditions: a systematic review
ConclusionsDue to concerns over quality and small sample sizes, we cannot yet recommend an existing BSCA diagnostic test without additional studies. However, the preliminary results found in the included studies and the technological advances described in excluded studies indicate excellent future potential. Research combining sophistical clinical and engineering skills is likely to be fruitful.Systematic review registrationThe review protocol (review ID number 42016054028) was developed by three authors (AI, KMW, and JM) and was published in the PROSPERO International prospective register of systematic reviews. It can be ...
Source: Systematic Reviews - August 17, 2018 Category: International Medicine & Public Health Source Type: research

Comparison of crystalloid resuscitation fluids for treatment of acute brain injury: a clinical and pre-clinical systematic review and network meta-analysis protocol
DiscussionThis systematic review will comprehensively summarize the difference in treatment efficacy of various crystalloid resuscitation fluids in acute brain injury. This review is essential to underscore the evidence, or lack thereof, present in the literature to date to support current preference-driven practice and to direct future study.Systematic review registrationPROSPERO#CRD42016042960 (Source: Systematic Reviews)
Source: Systematic Reviews - August 17, 2018 Category: International Medicine & Public Health Source Type: research

A methodological approach to identify the most reliable human milk collection method for compositional analysis: a systematic review protocol
DiscussionIt is important to identify the most reliable and practical method of human milk collection which best represents the average composition of the milk that is being consumed by the infant. This systematic review will be critical for ensuring that we determine a robust and consistent sampling approach to use in future studies of evaluating breast milk composition in a larger population. Identifying a recommended standard collection protocol will also provide more opportunities for sharing and combining data from different research groups, thus enhancing replicability and knowledge in the field.Systematic review reg...
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol
DiscussionThe aim of this systematic review is to provide a robust estimate of the prevalence of Lynch syndrome in women with endometrial cancer. This will enable resource allocation and decision-making regarding the appropriateness of screening all women, or certain women, with endometrial cancer for Lynch syndrome. Such a policy could enable the earlier diagnosis of Lynch syndrome in women and, through the application of colorectal cancer surveillance, improve their survival outcomes.Systematic review registrationThis systematic review has been registered on PROSPERO (refCRD42017081707). (Source: Systematic Reviews)
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

Indicators of deterioration in young adults with serious mental illness: a systematic review protocol
DiscussionThis systematic review will likely make a significant contribution to the field of mental health and help inform future research pertaining to interventions that help highlight deteriorating patients. This may vary depending on the patient group, mental illness or deterioration type.Systematic review registrationPROSPEROCRD42017075755 (Source: Systematic Reviews)
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

Evidence-based guidelines for physiotherapy management of patients with multiple myeloma: study protocol
DiscussionDraft guidelines will be developed in the form of action statements based on the strength of evidence and grades of recommendations. The draft guidelines will be reviewed internally by two independent reviewers using AGREE II and externally by a methodological expert from Evidence-Based Care – Cancer Care Ontario and will be sent to the Canadian Physiotherapy Association (CPA) for feedback from physiotherapists.Systematic review registrationPROSPEROCRD42017064056 (Source: Systematic Reviews)
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

(Update of a) systematic review on the impact of elective early term ( & lt;  39th gestational week) caesarean sections on maternal and neonatal health - a protocol
DiscussionOur aim is to reach a higher validity in the assessment of the time point of elective caesarean sections by performing a meta-analysis to support recommendations for clinical practice. We assume to identify less randomized controlled trials but a large number of cohort studies analyzing the given question. We will discuss similarities and differences in included studies as well as methodological strengths and weaknesses.Systematic review registrationPROSPEROCRD42017078231 (Source: Systematic Reviews)
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

How do the experiences and beliefs of adults and children with heterozygous familial hypercholesterolaemia influence their adherence to treatment? A systematic review of qualitative evidence protocol
DiscussionAdherence to treatment recommendations is crucial for the successful management of FH and subsequent decrease in risk of CHD later in life. Common identified themes could provide an understanding of the beliefs and experiences which influence adherence to treatment recommendations and provide an insight into perceived barriers and facilitators. The findings are intended to be used in the development of future interventions or guidelines regarding treatment of children and adults with FH.Systematic review registrationPROSPERO registration number:CRD42018085946 (Source: Systematic Reviews)
Source: Systematic Reviews - August 16, 2018 Category: International Medicine & Public Health Source Type: research

The use of clinical study reports to enhance the quality of systematic reviews: a survey of systematic review authors
ConclusionsMost respondents (irrespective of whether they had previously used them) agreed that access to CSRs is important, and suggest that further guidance on how to use and include these data would help to promote their use in future systematic reviews. Most respondents who received CSRs considered them to be valuable in their systematic review and/or meta-analysis. (Source: Systematic Reviews)
Source: Systematic Reviews - August 8, 2018 Category: International Medicine & Public Health Source Type: research

Quality and acceptability of patient-reported outcome measures used to assess fatigue in axial spondyloarthritis (axSpA): a systematic review (protocol)
This study will provide the first robust and transparent evaluation of patient-reported measures of fatigue used in the axSpA population, synthesising evidence of quality, relevance and acceptability. The review will benefit patients, clinicians, health professionals and researchers wishing to enhance axSpA-fatigue assessment in routine practice, service evaluation and research. The findings will impact future research which seeks to better understand the nature of axSpA fatigue and evaluate the relative benefit of fatigue-management strategies.Systematic review registrationPROSPEROCRD42016042271 (Source: Systematic Reviews)
Source: Systematic Reviews - August 7, 2018 Category: International Medicine & Public Health Source Type: research

What is the impact of sensory practices on the quality of life of long-term care residents? A mixed-methods systematic review protocol
The objective of this mixed-methods systematic review is to examine the relationship between the se nsory practices and the quality of life of residents living in long-term care settings and to develop an aggregated synthesis of mixed-methods studies to derive recommendations for policy, practice, and research.MethodsWe will conduct a mixed-methods systematic review in accordance with the Cochrane Handbook. A search strategy has been developed with an expert health sciences librarian and peer reviewed using Peer Review for Electronic Search Strategies (PRESS). Seven databases: MEDLINE (Ovid), PubMed (non-MEDLINE —Ovi...
Source: Systematic Reviews - August 4, 2018 Category: International Medicine & Public Health Source Type: research

Behavioral and cognitive interventions to improve treatment adherence and access to HIV care among older adults in sub-Saharan Africa: an updated systematic review
ConclusionsThese findings underscore the need to increase the evidence-base of which interventions will work for older Africans on ART. (Source: Systematic Reviews)
Source: Systematic Reviews - August 2, 2018 Category: International Medicine & Public Health Source Type: research

Sex/gender reporting and analysis in Campbell and Cochrane systematic reviews: a cross-sectional methods study
ConclusionOur study indicates that sex/gender reporting in Campbell and Cochrane reviews is inadequate. (Source: Systematic Reviews)
Source: Systematic Reviews - August 2, 2018 Category: International Medicine & Public Health Source Type: research

B-type natriuretic peptide-guided therapy for heart failure (HF): a systematic review and meta-analysis of individual participant data (IPD) and aggregate data
AbstractBackgroundWe estimated the effectiveness of serial B-type natriuretic peptide (BNP) blood testing to guide up-titration of medication compared with symptom-guided up-titration of medication in patients with heart failure (HF).MethodsSystematic review and meta-analysis of randomised controlled trials (RCTs). We searched: MEDLINE (Ovid) 1950 to 9/06/2016; Embase (Ovid), 1980 to 2016 week 23; the Cochrane Library; ISI Web of Science (Citations Index and Conference Proceedings). The primary outcome was all-cause mortality; secondary outcomes were death related to HF, cardiovascular death, all-cause hospital admission, ...
Source: Systematic Reviews - July 31, 2018 Category: International Medicine & Public Health Source Type: research

Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and Trial Sequential Analysis
ConclusionsIn a sample of Cochrane reviews, methods for assessing imprecision were rarely reported. GRADE according to Handbook guidelines and TSA led to more severe judgment of imprecision rather than GRADE adopted by reviews ’ authors. Cochrane initiatives to improve adherence to GRADE Handbook are warranted. TSA may transparently assist in such development. (Source: Systematic Reviews)
Source: Systematic Reviews - July 28, 2018 Category: International Medicine & Public Health Source Type: research

Single screen of citations with excluded terms: an approach to citation screening in systematic reviews
AbstractCitation screening during the systematic review process can be time-consuming due to the exponentially increasing amount of research. This letter describes an approach to expediting the process by single screening citations that include terms in the abstract and/or keywords related to the exclusion criteria of the systematic review to quickly reject studies with a high likelihood of being excluded from the systematic review. This method can potentially improve the efficiency of the citation screening process while maintaining the quality of the systematic review; however, future research is needed to further valida...
Source: Systematic Reviews - July 28, 2018 Category: International Medicine & Public Health Source Type: research

Realist-informed review of motivational interviewing for adolescent health behaviors
ConclusionsThis realist-informed systematic review provides advances in understanding the mechanisms involved in MI for adolescent health behavior change. Additionally, it provides important practical information as to which contexts create the conditions for these mechanisms to occur, leading to health behavior change. The results can inform future MI interventions for adolescent health behavior change. Future research should continue to test this realist theory and also examine mechanism variables not extensively documented in order to improve our understanding of MI in this population. (Source: Systematic Reviews)
Source: Systematic Reviews - July 27, 2018 Category: International Medicine & Public Health Source Type: research

Prevalence of chloroquine resistance alleles among Plasmodium falciparum parasites in countries affected by malaria disease since change of treatment policy: a systematic review protocol
DiscussionThe review seeks to establish the extent of chloroquine resistance reversal in malaria-endemic countries. The evidence generated from this review will help guide policy makers on the potential re-emerging role of chloroquine in malaria treatment.Systematic review registrationThe systematic review protocol has been registered in PROSPERO with registration number CRD42018083957. (Source: Systematic Reviews)
Source: Systematic Reviews - July 27, 2018 Category: International Medicine & Public Health Source Type: research

Brief interventions for cannabis use in emerging adults: protocol for a systematic review, meta-analysis, and evidence map
The objective of this systematic review is to s ummarize and critically appraise the existing literature of brief interventions for cannabis use both narratively, to describe the content and delivery of existing interventions, and meta-analytically, to determine the aggregated efficacy of these interventions on cannabis use and other outcomes (e. g., other substance use, mental health, help-seeking behaviors, and academic and occupational outcomes).MethodsA systematic search of randomized controlled trials, quasi-experimental trials, and pre-post designs will be conducted in the following electronic databases: MEDLINE, EMB...
Source: Systematic Reviews - July 25, 2018 Category: International Medicine & Public Health Source Type: research

Adherence to prenatal iron-folic acid supplementation in low- and middle-income countries (LMIC): a protocol for systematic review and meta-analysis
DiscussionContemporary evidence about the prevalence and determinants of adherence in LMIC will be synthesized to generate up-to-date knowledge. To our knowledge, this is the first systematic review. It would have substantial implications for researchers, clinicians, and policymakers for optimizing maternal and child health outcomes in LMIC.Systematic review registrationThe protocol has been registered on International Prospective Register of Systematic Review (PROSPERO), University of York Center for Reviews and Dissemination (https://www.crd.york.ac.uk/), registration numberCRD42017080245. (Source: Systematic Reviews)
Source: Systematic Reviews - July 25, 2018 Category: International Medicine & Public Health Source Type: research

Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol
This study will be reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines.DiscussionThis review will summarize the genetic effects of OCT1 polymorphisms associated with variabilities in glycemic responses to metformin. The findings of this study could help to develop genetic tests that could predict a person ’s response to metformin treatment and create personalized drugs with greater efficacy and safety.Systematic review registrationRegistration number: PROSPERO, CRD42017079978 (Source: Systematic Reviews)
Source: Systematic Reviews - July 25, 2018 Category: International Medicine & Public Health Source Type: research

Challenges of pain management in neurologically injured patients: systematic review protocol of analgesia and sedation strategies for early recovery from neurointensive care
DiscussionUsing the evidence from this systematic review, we anticipate disseminating knowledge of analgesia and sedation protocols in the NICU. The results of this systematic review are imperative to close the knowledge  gap in a patient population that is often excluded from studies, and to add to the body of literature aiming to enhance early recovery from the NICU and mitigate iatrogenic harm.Systematic review registrationPROSPEROCRD42017078909 (Source: Systematic Reviews)
Source: Systematic Reviews - July 24, 2018 Category: International Medicine & Public Health Source Type: research

Preoperative exercise therapy for gastrointestinal cancer patients: a systematic review
ConclusionsPET for surgical patients with gastrointestinal malignancies may improve physical fitness and aid in postoperative recovery. (Source: Systematic Reviews)
Source: Systematic Reviews - July 24, 2018 Category: International Medicine & Public Health Source Type: research

Evidence of factors influencing self-medication with antibiotics in LMICs: a systematic scoping review protocol
DiscussionThe study anticipates finding relevant studies reporting evidence on the factors influencing self-medication with antibiotics in LMICs. The evidence obtained from the included studies will help guide future research. The study findings will be disseminated electronically and in print with presentations being done at relevant platforms, i.e. conferences related to antibiotic use, antimicrobial resistance, health seeking behaviour and the use of medicines.Systematic review registrationProspero Registration Number: CRD42017072954 (Source: Systematic Reviews)
Source: Systematic Reviews - July 21, 2018 Category: International Medicine & Public Health Source Type: research

Patient-Oriented Research Competencies in Health (PORCH) for patients, healthcare providers, decision-makers and researchers: protocol of a scoping review
DiscussionResearch on core competencies required to enact POR is in its infancy. In this review, we can articulate what is known and thought about competencies (knowledge, skills and attitudes) needed by individuals on POR research teams and ultimately provide knowledge that could impact research, practice, education and policy. Identification of competencies can contribute to design of healthcare professionals ’ basic and ongoing educational programmes, patient training in research, and professional development activities for health care providers and decision-makers. In addition, knowledge of core competencies can ...
Source: Systematic Reviews - July 19, 2018 Category: International Medicine & Public Health Source Type: research

Relative frequency and risk factors for long-term opioid therapy following surgery and trauma among adults: a systematic review protocol
The objectives of this knowledge synthesis are to examine the relative frequenc y and the risk factors for transitioning to long-term opioid therapy among patients who have undergone a surgical procedure or experienced a trauma.MethodsThe proposed study methodology is based on Preferred ReportIng Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) statements on the conduct of systematic review and meta-analysis, the MOOSE Guidelines for Meta-Analyses and Systematic Reviews of Observational Studies, and theCochrane Handbook for Systematic Review of Interventions. A systematic literature search will include multiple da...
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Dietary intakes of flavan-3-ols and cardiovascular health: a field synopsis using evidence mapping of randomized trials and prospective cohort studies
ConclusionThrough a systematic, evidence-based approach, evidence mapping on flavan-3-ol intake and CVD outcomes demonstrated sufficient data relating to flavan-3ol intake and biomarkers and clinical outcomes of CVD and diabetes. The current evidence base highlights the distribution of available data which both support the development of a future systematic review and identified the research need for future long-term RCTs.Systematic review registrationAt present, evidence mapping is not eligible for registration on the international prospective register of systematic reviews (i.e., PROSPERO). (Source: Systematic Reviews)
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Gray literature in systematic reviews on population health in the Middle East and North Africa: protocol of an overview of systematic reviews and evidence mapping
DiscussionThis overview will comprehensively assess the overall quality of the SRs on population health issues in MENA. Our findings will contribute to the improvement of population health research practices in MENA.Systematic review registrationThe systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 26 October 2018 (registration number CRD42017076736 (Syst Rev 2:4, 2013). (Source: Systematic Reviews)
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of autologous fat grafting for wound healing
DiscussionIn light of the growing popularity of autologous fat grafting for wound healing, a systematic appraisal of the available evidence is timely. If autologous fat grafting is associated with a positive treatment effect, we will compare these outcomes to those achieved using alternative wound management strategies. This review also aims to determine if one or more autologous fat grafting techniques are superior and whether this varies according to patient- and wound-specific factors. We anticipate that these results will guide future research and inform clinical practice.Systematic review registrationPROSPERO CRD42017...
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Prevalence of type 2 diabetes, prediabetes, and gestational diabetes mellitus in women of childbearing age in Middle East and North Africa, 2000 –2017: protocol for two systematic reviews and meta-analyses
DiscussionPublished literature on the prevalence of different types of DM among different population groups has been recently increased in the MENA region. This is the first review to fill an evidence gap on the overall burden, in the form of prevalence, of T2DM, prediabetes, and GDM in women of childbearing age in the MENA region. The findings of the two reviews will help in understanding the regional burden of these three types of DM in specific population groups to identify priority areas for interventions.Systematic review registrationThe PROSPERO registration number for the systematic review 1 is “CRD42017069231...
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Dietary interventions for managing glucose abnormalities in cystic fibrosis: a systematic review protocol
DiscussionThis systematic review will elucidate current knowledge of the effects of dietary interventions for managing glucose abnormalities in the vulnerable CF clinical population.Systematic review registrationPROSPERO registration number:CRD42018085569www.crd.york.ac.uk/prospero/ (Source: Systematic Reviews)
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Cannabis for pediatric epilepsy: protocol for a living systematic review
DiscussionOur review aims to provide a comprehensive and up-to-date summary of the available evidence to inform decisions about the use of cannabis in children with treatment-resistant epilepsy. The results of this review will be of use to parents, clinicians, and policy makers as they navigate this rapidly evolving area.Systematic review registrationPROSPEROCRD42018084755 (Source: Systematic Reviews)
Source: Systematic Reviews - July 18, 2018 Category: International Medicine & Public Health Source Type: research

Pain rewarded: hyperalgesic and allodynic effect of operant conditioning in healthy humans —protocol for a systematic review and meta-analysis
DiscussionData will be pooled and analyzed qualitatively and quantitatively (if possible) in order to advance the understanding of pain mechanisms, especially the development of chronic pain. This systematic review will guide the planning of future experiments and research by summarizing important technical details of conditioning procedures in healthy humans.Systematic review registrationPROSPEROCRD42017051763 (Source: Systematic Reviews)
Source: Systematic Reviews - July 17, 2018 Category: International Medicine & Public Health Source Type: research

Quality of life of women who practice dance: a systematic review protocol
DiscussionThere is a variety of systematic review studies with men and women on quality of life and dance, but this is the first one focused exclusively on adult female audience. It is expected that this review will be useful to promote the discussion about quality of life of adult women and the interest of this population for dance practice. In order to summarize and to explain the characteristics and findings of those studies, tables and information from texts will be used in a systematic narrative synthesis.Systematic review registrationPROSPEROCRD42016039961 (Source: Systematic Reviews)
Source: Systematic Reviews - July 10, 2018 Category: International Medicine & Public Health Source Type: research

Neoadjuvant chemotherapy regimens in treatment of breast cancer: a systematic review and network meta-analysis protocol
DiscussionThe present systematic review will improve the understanding of the relative efficacies of the three treatment regimens and possibly guide the clinical practices by providing the current best evidence on the efficacy of various regimens of NACT in the management of breast cancer patients.Systematic review registrationPROSPERO (CRD42016027236). (Source: Systematic Reviews)
Source: Systematic Reviews - June 26, 2018 Category: International Medicine & Public Health Source Type: research

Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviour: a systematic review protocol
DiscussionTo determine whether neuromodulation holds promise as an effective treatment for neurocognitive deficits in substance use and addictive disorders, it is essential to look carefully at previous studies using this approach in addiction samples. This review will provide an objective and informative description of what is currently known about the efficacy of these techniques, shed light on the feasibility and potential challenges of using neuromodulation in individuals who exhibit addictive behaviour, and identify the most valuable next steps for future research. (Source: Systematic Reviews)
Source: Systematic Reviews - June 26, 2018 Category: International Medicine & Public Health Source Type: research

What happens for informal caregivers during transition to increased levels of care for the person with dementia? A systematic review protocol
DiscussionThe review will seek to identify potentially vulnerable groups in need of support and as such, inform the practice of those offering support. It will also inform future research by highlighting areas in which current literature is insubstantial.Systematic review registrationPROSPEROCRD42017067248 (Source: Systematic Reviews)
Source: Systematic Reviews - June 26, 2018 Category: International Medicine & Public Health Source Type: research

Barriers and facilitators to implementation of menu labelling interventions to support healthy food choices: a mixed methods systematic review protocol
DiscussionGiven the growing consensus that a systemic, sustained portfolio of obesity prevention strategies, delivered at scale, is needed to address the obesity epidemic, greater understanding of the practical issues relating to implementation of such strategies is required. Findings from this review will be used to develop a set of best-practice guidelines to enhance the adoption, implementation and sustainability of menu labelling interventions across countries worldwide.Systematic review registrationPROSPEROCRD42017083306 (Source: Systematic Reviews)
Source: Systematic Reviews - June 23, 2018 Category: International Medicine & Public Health Source Type: research

Reflections and aspirations: the journal after 5  years
AbstractThe journal recently celebrated its fifth anniversary. Like systematic reviews themselves, the journal is thriving and publishing a variety of protocols, reviews, and methods papers. We have also had success in publishing-themed series. (Source: Systematic Reviews)
Source: Systematic Reviews - June 20, 2018 Category: International Medicine & Public Health Source Type: research

A protocol for a systematic review of the diagnostic accuracy of Loop-mediated-isothermal AMPlification (LAMP) in diagnosis of invasive meningococcal disease in children
DiscussionThis review will help determine the diagnostic accuracy of LAMP technology in diagnosing MD from blood, CSF and throat swabs in children. The data will help to define where in the diagnostic pathway LAMP could be useful including potential as a point-of-care test for children at first presentation. (Source: Systematic Reviews)
Source: Systematic Reviews - June 15, 2018 Category: International Medicine & Public Health Source Type: research

Effectiveness of self-management support interventions for people with comorbid diabetes and chronic kidney disease: a systematic review and meta-analysis
AbstractBackgroundSelf-management support interventions may potentially delay kidney function decline and associated complications in patients with comorbid diabetes and chronic kidney disease. However, the effectiveness of these interventions remains unclear. We investigated the effectiveness of current self-management support interventions and their specific components and elements in improving patient outcomes.MethodsElectronic databases were systematically searched from January 1, 1994, to December 19, 2017. Eligible studies were randomized controlled trials on self-management support interventions for adults with como...
Source: Systematic Reviews - June 13, 2018 Category: International Medicine & Public Health Source Type: research

Evaluation of the reliability, usability, and applicability of AMSTAR, AMSTAR 2, and ROBIS: protocol for a descriptive analytic study
DiscussionAppraising the methodological and reporting quality of SRs is necessary to determine the trustworthiness of their conclusions. Which tool may be most reliably applied and how the appraisals should be used is uncertain; the usability of newly developed tools is unknown. This investigation of common (AMSTAR) and newly developed (AMSTAR 2, ROBIS) tools will provide empiric data to inform their application, interpretation, and refinement. (Source: Systematic Reviews)
Source: Systematic Reviews - June 13, 2018 Category: International Medicine & Public Health Source Type: research

mTOR-inhibiting pharmacotherapy for the treatment of non-infectious uveitis: a systematic review protocol
DiscussionStudies of various designs have investigated the clinical use of mTOR inhibitors for non-infectious uveitis, and a large international randomised controlled trail of sirolimus for non-infectious uveitis is due to report. The findings of this systematic review will help inform ophthalmologists and aid the improvement of treatment protocols for non-infectious uveitis with regard to the use of mTOR inhibitors.Systematic review registrationPROSPEROCRD42017056390 (Source: Systematic Reviews)
Source: Systematic Reviews - June 9, 2018 Category: International Medicine & Public Health Source Type: research

Predictors of human immunodeficiency virus (HIV) infection in primary care among adults living in developed countries: a systematic review
ConclusionThis systematic review consolidates existing scientific evidence on characteristics of HIV-infected individuals that could be used to inform decision making in prognostic model development. Further exploration of availability of some of the demographic and behavioural predictors of HIV, such as ethnicity, number of lifetime partners and partner characteristics, in primary care records will be required to determine whether they can be applied in the prediction model. (Source: Systematic Reviews)
Source: Systematic Reviews - June 2, 2018 Category: International Medicine & Public Health Source Type: research

Prevalence of anemia among school-age children in Ethiopia: a systematic review and meta-analysis
ConclusionsThis study found that prevalence of anemia was a moderate public health problem in school children. Due to the complications of anemia for school children, preventative planning and control of anemia among school children in Ethiopia is necessary. (Source: Systematic Reviews)
Source: Systematic Reviews - May 24, 2018 Category: International Medicine & Public Health Source Type: research

Older adult ’s experience of chronic low back pain and its implications on their daily life: Study protocol of a systematic review of qualitative research
DiscussionThis systematic review of qualitative evidence will enable researchers to identify potential unmet care needs, as well as to facilitate the development of effective, appropriate, person-centered health care interventions targeting this group of individuals.Systematic review registrationPROSPERO 2018:CRD42018091292 (Source: Systematic Reviews)
Source: Systematic Reviews - May 24, 2018 Category: International Medicine & Public Health Source Type: research

Health technology assessment of public health interventions: an analysis of characteristics and comparison of methods —study protocol
DiscussionOur analysis will provide a comprehensive and current overview of methods applied in HTAs on PHIs. We will discuss approaches that may be promising to overcome the challenges of evaluating PHIs. (Source: Systematic Reviews)
Source: Systematic Reviews - May 23, 2018 Category: International Medicine & Public Health Source Type: research