Systematic review of effectiveness of universal self-regulation-based interventions and their effects on distal health and social outcomes in children and adolescents: review protocol
DiscussionThe evidence derived from the systematic review will strengthen the evidence base to inform planning of effective interventions targeting self-regulation skills in childhood and adolescence. This will benefit policy makers, academicians, researchers, health professionals, and also, young people who will benefit from policy and interventions informed by this review.Systematic review registrationCRD42016047661. (Source: Systematic Reviews)
Source: Systematic Reviews - August 29, 2017 Category: International Medicine & Public Health Source Type: research

Patient satisfaction with E-Oral Health care in rural and remote settings: a systematic review protocol
DiscussionThe potential implications and benefits of E-Oral Health care can inform policymakers and health care professionals to take advantage of this technology to address health care challenges in these areas.Systematic review registrationPROSPEROCRD42016039942. (Source: Systematic Reviews)
Source: Systematic Reviews - August 29, 2017 Category: International Medicine & Public Health Source Type: research

Choice of initial antiretroviral drugs and treatment outcomes among HIV-infected patients in sub-Saharan Africa: systematic review and meta-analysis of observational studies
ConclusionThe risk of treatment failure and NNRTI switch were lower in patients who initiated with EFV than NVP-containing regimen. The review suggests that initiation of patients with EFV-containing regimen will reduce treatment failure and NNRTI switch. (Source: Systematic Reviews)
Source: Systematic Reviews - August 25, 2017 Category: International Medicine & Public Health Source Type: research

Barriers and facilitators to the integration of mental health services into primary health care: a systematic review protocol
DiscussionThe SPIDER framework has been chosen for this review because of its suitable application to qualitative and mixed methods research and will be used as a guide when selecting articles for inclusion. Data extracted will be synthesized using the “Best fit” framework because it has been used before and proved its suitability in producing new conceptual models for explaining decision-making and possible behaviors. Synthesizing evidence from countries across the globe will provide useful insights into the experiences of integrating mental health services into PHC and how the barriers and challenges have bee...
Source: Systematic Reviews - August 25, 2017 Category: International Medicine & Public Health Source Type: research

The HIV Care Cascade from HIV diagnosis to viral suppression in sub-Saharan Africa: a systematic review and meta-regression analysis protocol
DiscussionThis review will contribute to a better understanding of the HIV care cascade in SSA. It will help programs identify gaps and approaches to improve care and treatment for people living with HIV and reduce HIV transmission.Systematic review registrationPROSPERO CRD42017055863 (Source: Systematic Reviews)
Source: Systematic Reviews - August 25, 2017 Category: International Medicine & Public Health Source Type: research

Does Value Stream Mapping affect the structure, process, and outcome quality in care facilities? A systematic review
ConclusionsFor a final conclusion about Value Stream Mapping ’s effectiveness, more research with improved methodology is needed. Despite this lack of evidence, Value Stream Mapping has the potential to improve quality of care on the time dimension. The contextual influence has to be investigated to make conclusions about the relationship between different quality domains when applying Value Stream Mapping. However, for using this review’s conclusion, the limitation of including heterogeneous and potentially biased results has to be considered. (Source: Systematic Reviews)
Source: Systematic Reviews - August 24, 2017 Category: International Medicine & Public Health Source Type: research

Antibiotic exposure and risk of weight gain and obesity: protocol for a systematic review
DiscussionThis systematic review will summarize the existing evidence evaluating the association between antibiotic use, weight gain, and obesity and facilitate the identification of important gaps and uncertainties in the literature.Systematic review registrationPROSPEROCRD42017069177 (Source: Systematic Reviews)
Source: Systematic Reviews - August 24, 2017 Category: International Medicine & Public Health Source Type: research

The influence of contextual factors on healthcare quality improvement initiatives: what works, for whom and in what setting? Protocol for a realist review
DiscussionThe review will update and consolidate evidence on the contextual conditions for effective improvement and distil new knowledge to inform the design and development of context-sensitive QI initiatives. This review ties in with the study of improvement programmes as vehicles of change and the development of an evidence base around healthcare improvement by addressing whether QI initiatives can work in all contexts.Systematic review registrationPROSPEROCRD42017062135 (Source: Systematic Reviews)
Source: Systematic Reviews - August 23, 2017 Category: International Medicine & Public Health Source Type: research

Identifying additional studies for a systematic review of retention strategies in randomised controlled trials: making contact with trials units and trial methodologists
ConclusionsMethodological evaluations embedded in RCTs may be unpublished, published in the grey literature or where published, poorly indexed in bibliographic databases. To identify such studies and minimise selection bias in systematic reviews of methodological evaluations, reviewers should consider contacting CTUs and trial methodologists. (Source: Systematic Reviews)
Source: Systematic Reviews - August 22, 2017 Category: International Medicine & Public Health Source Type: research

Protocol for a scoping review to map evidence from randomised controlled trials on paediatric eye disease to disease burden
AbstractBackgroundCurrently, about 2 per 1000 children in the industrialised world are severely visually impaired or blind (SVI/BL) due to diverse uncommon conditions that are usually present from early infancy. The impact of SVI/BL is lifelong and life-changing. Thus, children are a priority in the WHO-led global initiative against avoidable blindness. The aim of this scoping review is to assess the current evidence base on interventions to prevent or treat the major causes of childhood SVI/BL, specifically the degree of alignment between robust interventional research (RCTs) and the burden (relative frequency) of the key...
Source: Systematic Reviews - August 18, 2017 Category: International Medicine & Public Health Source Type: research

Trends in maternal and neonatal mortality in South Africa: a systematic review protocol
This study aims to systematically review the estimates made of maternal and neonatal mortality in the period from 1990 to 2015 in South Africa and determine trends over this period.MethodsFor the purpose of this review, searches for eligible studies will be conducted in MEDLINE, Africa-Wide Information, African Index Medicus, African Journals Online, Scopus, Web of Science and CINAHL databases. Searches will be restricted to articles written in English and presenting data covering the period between 1990 and 2015. Reference lists of retrieved articles will also be screened for additional publications. Three independent rev...
Source: Systematic Reviews - August 17, 2017 Category: International Medicine & Public Health Source Type: research

Immediate versus delayed surgery for hip fractures in the elderly patients: a protocol for a systematic review and meta-analysis
DiscussionSince this is the first systematic review on this topic since 2010, our findings will help to inform clinical practice guidelines concerning timing of surgery in hip fractures. Furthermore, our findings could contribute to define an optimal time period for surgery for different groups of patients with acute hip fracture.Systematic review registrationPROSPERO 2017CRD42017058216 (Source: Systematic Reviews)
Source: Systematic Reviews - August 15, 2017 Category: International Medicine & Public Health Source Type: research

Adverse outcomes associated with opioid prescription for acute low back pain: a systematic review protocol
The objective of this review is to examine adverse outcomes associated with opioid use for ALBP.Methods/designUsing a search strategy, the search will be conducted using the following electronic databases: PubMed/MEDLINE, EMBASE, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Cochrane Library, the National Institutes for Health Clinical Trials Registry and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP). We will include randomized clinical trials and observational studies investigating the impact of opioid use in ALBP in the adult popul...
Source: Systematic Reviews - August 14, 2017 Category: International Medicine & Public Health Source Type: research

Adverse mental health outcomes in breast cancer survivors compared to women who did not have cancer: systematic review protocol
This study will be a systematic review of the literature. Four databases, including MEDLINE and PsycINFO, will be searched to identify potentially relevant studies. The search expressions will use a Boolean logic, including terms for the target population (women who have had breast cancer), outcomes (psychiatric disorders) and comparators (e.g. risk, hazard). All mental disorders will be eligible, except those with onset normally occurring during childhood or strong genetic basis (e.g. Huntington disease). The eligibility of the studies will be assessed in two phases: (1) considering the information provided in the title a...
Source: Systematic Reviews - August 14, 2017 Category: International Medicine & Public Health Source Type: research

Tobacco and alcohol cessation or reduction interventions in people with oral dysplasia and head and neck cancer: systematic review protocol
DiscussionThis systematic review will identify the extent of the current research on smoking and alcohol cessation interventions in patients with head and neck cancer and oral epithelial dysplasia. The findings have the potential to inform which interventions have been successful and how future behavioural change interventions should be conducted within these populations.Systematic review registrationPROSPEROCRD42016038237 (Source: Systematic Reviews)
Source: Systematic Reviews - August 10, 2017 Category: International Medicine & Public Health Source Type: research

Information sources for obesity prevention policy research: a review of systematic reviews
ConclusionsResearchers can maximize search efficiency by searching a small yet targeted selection of both scholarly and gray literature resources. A highly sensitive search of PubMed and those databases that index the greatest number of relevant articles not indexed in PubMed, namely multidisciplinary and economics databases, could save considerable time and effort. When combined with a gray literature search and additional search methods, including cited reference searching and consulting with experts, this approach could help maintain broad retrieval of relevant studies while improving search efficiency. Findings also ha...
Source: Systematic Reviews - August 8, 2017 Category: International Medicine & Public Health Source Type: research

Effectiveness of person- and family-centered care transition interventions: a systematic review protocol
DiscussionThis systematic review will summarize and present the evidence base for person- and family-centered care transition interventions. This review will also inform further research and will lay the groundwork for more empirical studies on person- and family-centered care transitions. Specifically, the results of this systematic review may inform the development of measures to monitor safe and effective person- and family-centered transitions from the hospital to home. These results may also be important for policy makers, decision-makers, clinicians, and patients/families who are involved in navigating the health car...
Source: Systematic Reviews - August 8, 2017 Category: International Medicine & Public Health Source Type: research

Continuing education for the prevention of mild cognitive impairment and Alzheimer ’s-type dementia: a systematic review protocol
DiscussionWe anticipate that our review will highlight serious gaps in the current evidence. Results will build the basis for further research regarding the relation of continuing education and cognitive decline and dementia.Systematic review registrationPROSPEROCRD42017063944 (Source: Systematic Reviews)
Source: Systematic Reviews - August 8, 2017 Category: International Medicine & Public Health Source Type: research

Hepatitis C infection epidemiology in Mongolia: protocol of a systematic review and meta-analysis
DiscussionThe proposed systematic review and meta-analysis will produce a comprehensive synthesis of HCV epidemiology in Mongolia. The study will provide empirical evidence to inform health policy decision-making, resource allocation, and planning and implementation of relevant public health interventions.Systematic review registrationWe have not registered with PROSPERO (Source: Systematic Reviews)
Source: Systematic Reviews - August 8, 2017 Category: International Medicine & Public Health Source Type: research

Challenges and opportunities in country-specific research synthesis: a case study from Cameroon
ConclusionKnowledge synthesis approaches can be adapted for appraisal of country-specific research and offer opportunities for in-depth appraisal of research output. (Source: Systematic Reviews)
Source: Systematic Reviews - August 8, 2017 Category: International Medicine & Public Health Source Type: research

Structural barriers in access to medical marijuana in the USA —a systematic review protocol
DiscussionThe overarching goal of this study is to rigorously evaluate the existing peer-reviewed data on access to medical marijuana in the USA. Income, ethnic background, stigma, and physician preferences have been posited as the primary structural barriers influencing medical marijuana patient population demographics in the USA. Identification of structural barriers to accessing medical marijuana provides a framework for future policies and programs. Evidence-based policies and programs for increasing medical marijuana access help minimize the disparity of access among qualifying patients. (Source: Systematic Reviews)
Source: Systematic Reviews - August 7, 2017 Category: International Medicine & Public Health Source Type: research

A systematic review of decision aids that facilitate elements of shared decision-making in chronic illnesses: a review protocol
This study will characterize DAs for chronic illness and will provide an overview of their effects on SDM, clinical and patient reported outcomes. We anticipate this review will bring to light knowledge gaps and inform further research into the design and use of DAs for patients with chronic conditions.Systematic review registrationPROSPERO registration number:CRD42016050320. (Source: Systematic Reviews)
Source: Systematic Reviews - August 7, 2017 Category: International Medicine & Public Health Source Type: research

Increasing value and reducing waste in data extraction for systematic reviews: tracking data in data extraction forms
AbstractData extraction is one of the most time-consuming tasks in performing a systematic review. Extraction is often onto some sort of form. Sharing completed forms can be used to check quality and accuracy of extraction or for re-cycling data to other researchers for updating. However, validating each piece of extracted data is time-consuming and linking to source problematic.In this methodology paper, we summarize three methods for reporting the location of data in original full-text reports, comparing their advantages and disadvantages. (Source: Systematic Reviews)
Source: Systematic Reviews - August 4, 2017 Category: International Medicine & Public Health Source Type: research

Abuse and disrespect in childbirth process and abortion situation in Latin America and the Caribbean —systematic review protocol
DiscussionData will be extracted using standardized forms with the following information: scope of study, sample characteristics, objectives, design, data collection, methods of analysis, data source, and results. Considering the heterogeneity of the definitions of abuse, disrespect, and mistreatment of women in labor or abortion, it may not be possible to carry out the meta-analysis of the frequency of events reported in the included articles. Events reported by the original articles will be classified according to a typology of abuse, disrespect, and maltreatment in the labor or abortion process described by Bohren et al...
Source: Systematic Reviews - August 3, 2017 Category: International Medicine & Public Health Source Type: research

Complications and health-related quality of life after robot-assisted versus open radical cystectomy: a systematic review and meta-analysis of four RCTs
ConclusionOur review presents evidence for RARC not being superior to ORC regarding complications, LOS and HRQoL. High-quality studies with consistent registration of complications and patient-related outcomes are warranted.Systematic review registrationPROSPEROCRD42016038232 (Source: Systematic Reviews)
Source: Systematic Reviews - August 2, 2017 Category: International Medicine & Public Health Source Type: research

Protocol: systematic review of the association between socio-economic status and survival in adult head and neck cancer
DiscussionThis review will quantify the association between SES and survival outcomes for adult head and neck cancer patients in developed countries. The results will help identify gaps in the literature and therefore direct further novel research in the field. Ultimately, this will inform public policy and strategies to reduce the inequalities in HNSCC survival.Systematic review registrationPROSPEROCRD42016037019. (Source: Systematic Reviews)
Source: Systematic Reviews - August 2, 2017 Category: International Medicine & Public Health Source Type: research

The influence of the team in conducting a systematic review
AbstractThere is an increasing body of research documenting flaws in many published systematic reviews ’ methodological and reporting conduct. When good systematic review practice is questioned, attention is rarely turned to the composition of the team that conducted the systematic review. This commentary highlights a number of relevant articles indicating how the composition of the review team cou ld jeopardise the integrity of the systematic review study and its conclusions. Key biases require closer attention such as sponsorship bias and researcher allegiance, but there may also be less obvious affiliations in tea...
Source: Systematic Reviews - August 1, 2017 Category: International Medicine & Public Health Source Type: research

Producing Cochrane systematic reviews —a qualitative study of current approaches and opportunities for innovation and improvement
ConclusionsThe findings of this study will inform the development of new Cochrane Review production models and may provide valuable data for other systematic review producers as they consider how best to produce rigorous, reliable, up-to-date reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - August 1, 2017 Category: International Medicine & Public Health Source Type: research

Usability evaluation methods employed to assess information visualisations of electronically stored patient data for clinical use: a protocol for a systematic review
DiscussionThis systematic review will identify methods used to assess the usability of electronic information visualisations of patient data for clinical use. We will summarise the similarities and differences between the methods found. Our results will inform best practice when developing new user interfaces to display electronic patient data for clinical use.Trial registrationPROSPERO CRD42016041604 (Source: Systematic Reviews)
Source: Systematic Reviews - July 28, 2017 Category: International Medicine & Public Health Source Type: research

Systematic review adherence to methodological or reporting quality
ConclusionsAlthough reporting guidelines and quality assessment tools exist, reporting and methodological quality of SRs are inconsistent. Mechanisms to improve adherence to established reporting guidelines and methodological assessment tools are needed to improve the quality of SRs. (Source: Systematic Reviews)
Source: Systematic Reviews - July 19, 2017 Category: International Medicine & Public Health Source Type: research

Selecting and implementing overview methods: implications from five exemplar overviews
ConclusionsOverviews are a relatively new methodological innovation, and there are currently substantial variations in the methodological approaches used within different overviews. There are considerable methodological challenges for which optimal solutions are not necessarily yet known. Lessons learnt from five exemplar overviews highlight a number of methodological decisions which may be beneficial to consider during the development of an overview protocol. (Source: Systematic Reviews)
Source: Systematic Reviews - July 18, 2017 Category: International Medicine & Public Health Source Type: research

The utility of mini-Clinical Evaluation Exercise (mini-CEX) in undergraduate and postgraduate medical education: protocol for a systematic review
The objective of this BEME review is to explore, analyze, and synthesize the evidence considering the utility of the mini-CEX for assessing undergraduate and postgraduate medical trainees.MethodsStudies reporting on mini-CEX performed in undergraduate and postgraduate medical education and providing some empirical data for mini-CEX in relation to one or more of the validity, reliability, educational impact, acceptability, and cost of mini-CEX will be included in the review. No restrictions on study design or publication date or language will be handled. To ensure comprehensiveness of our search, we will use different appro...
Source: Systematic Reviews - July 18, 2017 Category: International Medicine & Public Health Source Type: research

Psychosocial interventions for managing occupational stress and burnout among medical doctors: a systematic review
ConclusionThis review found that despite increased scientific attention, the quality of research examining the benefits of psychosocial/behavioural interventions for occupational stress and burnout in medical doctors remains low. Despite this, interventions focused on cognitive and behavioural principles appear to show promise in reducing doctor stress and burnout. Limitations of the current review include a lack of risk of bias assessment or pooling of analyses. Recommendations for improving the quality of research in this area, as well as implications of the current body of evidence are discussed.Systematic review regist...
Source: Systematic Reviews - July 17, 2017 Category: International Medicine & Public Health Source Type: research

Continuous surveillance of a pregnancy clinical guideline: an early experience
ConclusionsFurther resources are needed in updating the CG field, both for implementing updating strategies and for developing methodological research. (Source: Systematic Reviews)
Source: Systematic Reviews - July 14, 2017 Category: International Medicine & Public Health Source Type: research

Influence of genetic variants on toxicity to anti-tubercular agents: a systematic review and meta-analysis (protocol)
DiscussionOur review and meta-analysis will update and add to the existing research in this field. By not restricting the scope of the review to a specific drug, genetic variant, or toxicity outcome, we hope to synthesise data for associations between genetic variants and anti-tuberculosis drug-related toxicity outcomes that have previously not been summarised in systematic reviews, and consequently, add to the knowledge base of the pharmacogenetics of anti-tuberculosis drugs.Systematic review registrationPROSPERO CRD42017068448 (Source: Systematic Reviews)
Source: Systematic Reviews - July 13, 2017 Category: International Medicine & Public Health Source Type: research

Criteria and models for the distribution of casualties in trauma-related mass casualty incidents: a systematic literature review protocol
This study will comprehensively investigate existing papers with search phrases and terms including “mass casualty incident”, distribution, evacuation, and Mesh terms directly corresponding to search phrases. No limitations on the type of studies, date of publication, or language of the relevant documents will be imposed. PubMed, Web of Science, Scopus, and Google Scholar will be searched to a ccess the relevant documents. Included papers will be critically appraised by two independent reviewers. The data including incidents type, scene characteristics, patient features, pre-hospital resources, and hospital res...
Source: Systematic Reviews - July 12, 2017 Category: International Medicine & Public Health Source Type: research

Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: protocol for a systematic review
DiscussionThis systematic review will provide a foundation of evidence regarding ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries. Using the social ecological model as a conceptual framework will facilitate the understanding of broader influences of the sociocultural context on an individual ’s experience with clinical genetic testing and counseling, thereby informing interdisciplinary sectors in future recommendations for practice and policy.Systematic review registrationPROSPERO CRD42016042894 (Source: Systematic Reviews)
Source: Systematic Reviews - July 11, 2017 Category: International Medicine & Public Health Source Type: research

Effects of transcutaneous electrical nerve stimulation (TENS) on proinflammatory cytokines: protocol for systematic review
This study systematically reviews the literature on the effect of TENS on proinflammatory cytokines.MethodsA systematic review protocol was developed based on searches of articles in six electronic databases and references of retrieved articles, contact with authors, and repositories of clinical trials. Eligibility criteria: publication in peer-reviewed journals, randomized clinical trials, use of TENS in the experimental group, and pre- and post-measurements of proinflammatory cytokines in the blood. Selection of the studies and extraction of the data will be carried out by two reviewers independently. Characteristics of ...
Source: Systematic Reviews - July 11, 2017 Category: International Medicine & Public Health Source Type: research

Delay discounting differences in brain activation, connectivity, and structure in individuals with addiction: a systematic review protocol
The objective of this systematic review is to summarize and critically appraise the existing literature examining differences between addicted and healthy individuals in the neural correlates of DRD using magnetic resonance imaging (MRI) or functional magnetic resonance imaging (fMRI).MethodsA systematic search strategy will be implemented that uses Boolean search terms in PubMed/MEDLINE and PsycINFO, as well as manual search methods, to identify the studies comprehensively. This review will include studies using MRI or fMRI in humans to directly compare brain activation, functional connectivity, or structure in relation t...
Source: Systematic Reviews - July 11, 2017 Category: International Medicine & Public Health Source Type: research

Anorexia nervosa and cancer: a protocol for a systematic review and meta-analysis of observational studies
This study protocol is part of a systematic collection and assessment of multiple systematic reviews and meta-analyses (umbrella review) evaluating the association of cancer and multiple central nervous system disorders. We designed a specific protocol for a new systematic review and meta-analysis of observational studies of anorexia nervosa with risk of developing or dying from any cancer. Data sources will be PubMed, Embase, Scopus, Web of Science, and manual screening of references. Observational studies (case –control and cohort) in humans that examined the association between anorexia nervosa and risk of develop...
Source: Systematic Reviews - July 11, 2017 Category: International Medicine & Public Health Source Type: research

Evidence for a comprehensive approach to Aboriginal tobacco control to maintain the decline in smoking: an overview of reviews among Indigenous peoples
ConclusionsThere is limited Indigenous-specific evidence for most tobacco interventions. A ‘comprehensive approach’ incorporating NTS and NATSIHP Principles and Priorities of partnership and engagement, evidence from other settings, programme logic and responsive evaluation plans may improve intervention acceptability, effectiveness and implementation and mitigate risks of adapting to bacco evidence for Indigenous Australians. (Source: Systematic Reviews)
Source: Systematic Reviews - July 10, 2017 Category: International Medicine & Public Health Source Type: research

Clinical manifestations and diagnostic methods in pulmonary angiosarcoma: protocol for a scoping review
DiscussionScoping reviews are increasingly used to synthesize the evidence on a particular topic, to identify gaps in the literature, and to determine if future systematic reviews are feasible. In order to improve the care of patients with angiosarcoma, earlier recognition and diagnosis is required. This review will be valuable for highlighting the range of clinical presentations and the role of imaging and other diagnostic tools in the diagnosis of metastatic and primary pulmonary angiosarcoma.Systematic review registrationPROSPERO registration:CRD42017059052 (Source: Systematic Reviews)
Source: Systematic Reviews - July 10, 2017 Category: International Medicine & Public Health Source Type: research

The effect and safety of postmenopausal hormone therapy and selective estrogen receptor modulators on kidney outcomes in women: a protocol for systematic review and meta-analysis
DiscussionBy examining the effects of postmenopausal hormone therapy and selective estrogen receptor modulators on kidney function and albuminuria, the results of this systematic review and meta-analysis will inform management of postmenopausal women in the general population. Furthermore, it will evaluate the safety, including the risks of known adverse outcomes of postmenopausal hormone therapy and selective estrogen receptor modulators, in the already vulnerable chronic kidney disease population.Systematic review registrationPROSPERO CRD42016050651 (Source: Systematic Reviews)
Source: Systematic Reviews - July 7, 2017 Category: International Medicine & Public Health Source Type: research

Physical frailty and functional status in patients with advanced kidney disease: a protocol for a systematic review
DiscussionThe results of this review will inform the development, selection, and validation of appropriate metrics needed to improve prognostication in patients with chronic kidney disease.Systematic review registrationPROSPEROCRD42016045251 (Source: Systematic Reviews)
Source: Systematic Reviews - July 6, 2017 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of N-of-1 trial protocol guidelines and protocol reporting guidelines
The objective of this study is to evaluate current literature on N-of-1 design and reporting to identify key elements of rigorous N-of-1 protocol design.MethodsWe will conduct a systematic search for all N-of-1 trial guidelines and protocol-reporting guidelines published in peer-reviewed literature. We will search Medline, Embase, PsycINFO, CINAHL, the Cochrane Methodology Register, CENTRAL, and the NHS Economic Evaluation Database. Eligible articles will contain explicit guidance on N-of-1 protocol construction or reporting. Two reviewers will independently screen all titles and abstracts and then undertake full-text revi...
Source: Systematic Reviews - July 6, 2017 Category: International Medicine & Public Health Source Type: research

Management of frailty: a protocol of a network meta-analysis of randomized controlled trials
DiscussionTo the best of our knowledge, this will be the first systematic review and network meta-analysis considering the direct and indirect effect of interventions targeting frailty prevention or treatment. Given the established high prevalence and socio-economic burden of frailty, there is an urgent need for a high-quality systematic review to inform evidence-based management of frailty.Systematic review registrationPROSPERO 2016CRD42016037465. (Source: Systematic Reviews)
Source: Systematic Reviews - July 5, 2017 Category: International Medicine & Public Health Source Type: research

Impact of body size, nutrition and socioeconomic position in early life on the epigenome: a systematic review protocol
DiscussionThis protocol will be used to collate the evidence for the effect of early life factors on the epigenome. Findings will form a component of a wider research study examining epigenetic responses to exposures in early life and over the life course and its impact on healthy ageing using data from population-based cohort studies.Systematic review registrationPROSPERO CRD42016050193 (Source: Systematic Reviews)
Source: Systematic Reviews - July 5, 2017 Category: International Medicine & Public Health Source Type: research

Is health coaching effective in changing the health status and behaviour of prisoners? —a systematic review protocol
DiscussionThis systematic review will identify and gather evidence on the impact of health coaching interventions delivered in the prison setting and can function as a supporting material for health professionals, prison staff, the healthcare system, and public health departments when considering delivering health coaching.Systematic review registrationPROSPEROCRD42016053237. (Source: Systematic Reviews)
Source: Systematic Reviews - July 3, 2017 Category: International Medicine & Public Health Source Type: research

Telephone consultations for general practice: a systematic review
ConclusionThere is a lack of high level evidence for telephone consultations in a GP setting; however, current evidence suggests that telephone consultations as an alternative to face-to-face general practice consultations offers an appropriate option in certain settings.Systematic review registrationPROSPEROCRD42015025225 (Source: Systematic Reviews)
Source: Systematic Reviews - July 3, 2017 Category: International Medicine & Public Health Source Type: research

Quality indicators for care of depression in primary care settings: a systematic review
ConclusionsThe identified set of indicators address multiple dimensions of depression care and provide an excellent starting point for further development and use in primary care settings. (Source: Systematic Reviews)
Source: Systematic Reviews - July 3, 2017 Category: International Medicine & Public Health Source Type: research