Is increased carer knowledge of the health care system associated with decreased preventable hospitalizations for people in the community diagnosed with dementia? A systematic review protocol
This study aims to assess the effectiveness of interventions focused on reducing avoidable hospitalization for PLWD by supporting carers to manage the health care needs of the PLWD, via improved awareness and understanding of health and the healthcare system.MethodScientific and gray literature will be searched using a combination of keywords pertaining to dementia, caregivers, education, and support. Included studies will involve community-dwelling PLWD and caregivers, with interventions aimed at improving carer ’s understanding of the healthcare system and ability to manage the caregiving role. The primary outcome ...
Source: Systematic Reviews - November 24, 2018 Category: International Medicine & Public Health Source Type: research

The relationship between a trusted adult and adolescent outcomes: a protocol of a scoping review
This study is a scoping review. A broad range of databases will be searched, including MEDLINE, ERIC, Education Abstracts, Web of Science, ASSIA, Sociological Abstracts, and PsycINFO. Predefined inclusion/exclusion criteria will be used, with a focus on outcomes relating to health and education. Two reviewers will blind screen papers independently at all screening stages, with conflicts being resolved by a third reviewer. Quantitative and qualitative studies, as well as unpublished (grey) literature/reports, will be included. We will use the World Health Organization ’s ‘second decade’ definition of adole...
Source: Systematic Reviews - November 24, 2018 Category: International Medicine & Public Health Source Type: research

Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders: a protocol for a systematic review
The objective of the current protocol is to provide the methodology for a systematic review regarding the effects of Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders.MethodThis protocol was developed according to the Preferred Reporting Items for Systematic reviews and Meta-analyses for Protocols (PRISMA-P) 2015 guidelines. Electronic database searches will include EBSCOhost, PubMed and Cochrane Central Register performed by two researchers. This will be complemented by searching other resources such as the reference lists for included studies to identify studies meeting the elig...
Source: Systematic Reviews - November 23, 2018 Category: International Medicine & Public Health Source Type: research

The safety and efficacy of on-site paramedic and allied health treatment interventions targeting the reduction of emergency department visits by long-term care patients: systematic review protocol
DiscussionAs pressure on the healthcare system continues to rise, many areas are looking for alternative models of care. Several programs have been put in place in long-term care centers that seek to avoid transportation to the emergency department by providing enhanced care on-site. These programs are quite variable, and, to date, there is no standardized program or model of care.Systematic review registrationPROSPERO (CRD42018091636) (Source: Systematic Reviews)
Source: Systematic Reviews - November 23, 2018 Category: International Medicine & Public Health Source Type: research

Integrated models of care for diabetes and hypertension in low- and middle-income countries (LMICs)  : Protocol for a systematic review
DiscussionIn light of limited evidence on the provision of comprehensive care for diabetes and hypertension, and its comorbidity in LMCIs, we believe that the findings of this systematic review will provide a synthesis of evidence on effective models of integrated care for diabetes and hypertension and their comorbidities at primary healthcare level. This will enable policy-makers to device policies and programs that are evidence informed.Systematic review registrationPROSPEROCRD42018099314. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

CYP genetic variants and toxicity related to anti-tubercular agents: a systematic review and meta-analysis
ConclusionsGenerally, we identified that coverage of the association between SNPs ofCYP genes and anti-tuberculosis drug-related toxicity outcomes is incomplete. We observed significant associations between theRsaI and 96-bp deletion-insertion SNPs of theCYP2E1 gene and anti-tuberculosis drug-related hepatotoxicity. We were unable to comment on the impact of ethnicity on the investigated associations, as information on participants ’ ethnicity was sparsely reported in the included studies.Systematic review registrationPROSPERO registration number: CRD42017068448. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

The impact of musculoskeletal injuries sustained in road traffic crashes on work-related outcomes: a protocol for a systematic review
DiscussionThe results of this systematic review may increase our knowledge of work-related outcomes and understanding of the associated factors for people with musculoskeletal injuries following road traffic crashes. Future studies could use the results to plan interventions and influence policy and legislation, and raise awareness of the needs of this clinical population.Systematic review registrationRegistered on PROSPERO, reference numberCRD42018099252, dated 14 August 2018. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

Mapping evidence on decision-making on contraceptive use among adolescents: a scoping review protocol
DiscussionUnderstanding how adolescents make decisions about whether or not to use contraception is essential for improving contraceptive prevalence rates in this special population. It is envisioned that the results from this review will highlight key evidence on how adolescent make decisions regarding contraceptive use as well as gaps and opportunities for future research. It will also be important in enhancing and re-focusing adolescent sexual and reproductive health policies and programmes. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

Searching Embase and MEDLINE by using only major descriptors or title and abstract fields: a prospective exploratory study
ConclusionsOf the four search options, two options substantially reduced the overall search yield. However, this also resulted in a greater chance of losing relevant references, even though many references were still found in other databases such as Web of Science. (Source: Systematic Reviews)
Source: Systematic Reviews - November 20, 2018 Category: International Medicine & Public Health Source Type: research

Prevention of cervical cancer in HIV-seropositive women from developing countries through cervical cancer screening: a systematic review
ConclusionAlthough cervical cancer screening exists in almost all developing countries, what is missing is both opportunistic and systematic organised population-based screenings. Cervical cancer screening programmes need to be integrated into already existing HIV services to enable early detection and treatment. There is a need to offer opportunistic and coordinated screening programmes that are provider-initiated to promote early identification of cervical precancerous lesions.Systematic review registrationPROSPEROCRD42018095702 (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

Time-to-update of systematic reviews relative to the availability of new evidence
ConclusionA minority of 2010 Cochrane reviews were updated before June 2017 to incorporate evidence from new primary studies, and very few updates led to a change in conclusion. We did not find clear evidence that updates were undertaken faster when new evidence was made available. New approaches for finding early signals that a systematic review conclusion is at risk of change may be useful in allocated resources to the updating of systematic reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

Use of indices to measure socio-economic status (SES) in South-Asian urban health studies: a scoping review
ConclusionThis scoping review identifies asset-based wealth index as the most frequently used indices for measuring socioeconomic status in South Asian urban health studies. This review also provides a clear idea about the use of other indices for the measurement SES in the region. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

The effect of rehabilitation interventions on physical function and immobility-related complications in severe stroke —protocol for a systematic review
DiscussionThe results of this systematic review will summarise the strength of evidence for rehabilitation interventions used in the rehabilitation of physical function and immobility-related complications in severe stroke and identify gaps in evidence.Systematic review registrationThe systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) —registration numberCRD77737. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

K13-propeller gene polymorphisms in Plasmodium falciparum parasite population: a systematic review protocol of burden and associated factors
This study will collate evidence from previous studies on the commonly reported K13 -gene polymorphisms amongP. falciparum parasites in malaria-affected countries.Systematic review registrationPROSPERO CRD 42018084624 (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2018 Category: International Medicine & Public Health Source Type: research

The quality of clinical practice guidelines for management of pediatric type 2 diabetes mellitus: a systematic review using the AGREE II instrument
ConclusionsOverall, two thirds of the pediatric T2DM guidelines were moderate to low quality and the remaining third ranked higher in quality. Low quality was especially due to the scores for the “Rigour of Development” domain, which directly measures guideline development methodology. It is important that future guidelines and updates of existing guidelines improve the methodology of development and quality of reporting in order to appropriately guide physicians managing children and ad olescents with T2DM.Systematic review registrationPROSPEROCRD42016034187 (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2018 Category: International Medicine & Public Health Source Type: research

Can automated content analysis be used to assess and improve the use of evidence in mental health policy? A systematic review
ConclusionsAutomated content analysis may be useful in assessing and improving the use of evidence in mental health policies. Wordscores is an automated content analysis option for comparing policy and research texts that could be used by both researchers and policymakers. (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2018 Category: International Medicine & Public Health Source Type: research

Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol
DiscussionThis systematic review and meta-analysis will investigate both safety and efficacy ofM. charantia preparations in type 2 diabetes mellitus. The review results will be published in a peer-reviewed journal. The results will bring better understanding of clinical outcomes in treatment of type 2 diabetes mellitus patients and highlight gaps for future research.Systematic review registrationPROSPEROCRD42018083653. (Source: Systematic Reviews)
Source: Systematic Reviews - November 15, 2018 Category: International Medicine & Public Health Source Type: research

Herceptin ® (trastuzumab) in HER2-positive early breast cancer: a systematic review and cumulative network meta-analysis
ConclusionThis analysis represents the most comprehensive SLR/cNMA to date of published OS data in HER2+ EBC studies. These findings demonstrate why H/chemotherapy is now the established standard of care in HER2+ EBC. In the case of H, the benefits of early patient access far outweighed the risk of waiting for more precise information.Systematic review registrationPROSPEROCRD42017055763 (Source: Systematic Reviews)
Source: Systematic Reviews - November 14, 2018 Category: International Medicine & Public Health Source Type: research

Healthcare provider knowledge, attitudes, beliefs, and practices surrounding the prescription of opioids for chronic non-cancer pain in North America: protocol for a mixed-method systematic review
DiscussionThe ultimate goal of this work is to support interventions aiming to optimize opioid prescribing practices in order to prevent opioid-related morbidity and mortality without restricting a HCP ’s ability to select the most appropriate treatment for an individual patient.Systematic review registrationPROSPEROCRD42018091640. (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Barriers to access and utilization of emergency obstetric care at health facilities in sub-Saharan Africa: a systematic review of literature
ConclusionsA number of factors were found to hamper access to and utilization of emergency obstetric care among women in sub-Saharan Africa. These barriers are inter-dependent and occurred at multiple levels either at home, on the way to health facilities, or at the facilities. Therefore, country-specific holistic strategies including improvements to healthcare systems and the socio-economic status of women need to be strengthened. Further research should focus on the assessment of the third delay, as little is known about facility-readiness.Systematic review registrationPROSPERO CRD42017074102 (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

A systematic review and synthesis of theories of change of school-based interventions integrating health and academic education as a novel means of preventing violence and substance use among students
ConclusionsEroding ‘boundaries’ between health and academic education, teachers and students, classrooms and the wider school and schools and families were seen to be the most critical to establishing new frameworks of family, classroom or school organisation that are conducive to promoting both academic and socia l-emotional outcomes. Whether such interventions are feasible to implement and effective in reducing risk behaviours will be examined in other reports arising from the review. (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of venous coupler devices versus hand-sewn anastomosis for microsurgical free flap reconstruction
DiscussionThere has been no comparison of coupled and hand-sewn venous anastomoses using a robust and validated methodology preceded by a protocol and performing meta-analysis. Included studies are expected to be mainly observational and prone to bias; however, there is value in summarising the evidence, assessing its risk of bias and performing meta-analysis to guide clinicians. By using a broad approach including all types of flaps, we foresee inherent differences regarding the unit of analysis and different anatomic sites. This will limit the validity of our conclusions but is unavoidable. We will seek unpublished data ...
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Relationship between volume and outcome for congenital diaphragmatic hernia: a systematic review protocol
DiscussionGiven the lack of a comprehensive summary of findings on the relationship between hospital or surgeon volume and outcomes for congenital diaphragmatic hernia, this systematic review will put things right. Results can be used to inform decision makers or clinicians and to adapt medical care.Systematic review registrationPROSPERO (CRD42018090231) (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

What influences women ’s movement and the use of different positions during labour and birth: a systematic review protocol
DiscussionThe findings of this review will allow researchers, practitioners and policy makers to better understand the factors influencing women ’s movement and the use of different positions during labour and birth. This will inform future research and the development of maternity services designed to implement best-evidence concerning movement and positioning during labour and birth into clinical practice.Systematic review registrationIn accordance with the PRISMA-P guidelines (Moher et al. Syst Rev 4:1, 2015), the systematic review protocol was registered with the International Prospective Register of Systematic r...
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Systematic review of the surgical management of rotator cuff repair with an augmentative patch: a feasibility study protocol
DiscussionThis review aims to collate the current evidence base regarding the use of patches to augment rotator cuff repair. The results of this review will help to develop, using consensus methods, the design of a definitive randomised trial assessing the clinical and cost-effectiveness of a patch to augment surgical repair of the rotator cuff that is both acceptable to stakeholders and is feasible.Systematic review registrationCRD42017057908 (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Body image dissatisfaction in patients with inflammatory bowel disease: a systematic review protocol
DiscussionTo the best of our knowledge, this will be the first systematic review to collate the existing evidence on BID in IBD patients. Understanding the impact of BID, its relationship with quality of life, and which patients may be at greater risk, may ultimately lead to the development of interventions to prevent or treat BID and to better patient care. Any gaps in the identified evidence will help to inform the research agenda in this area.Systematic review registrationPROSPERO: (CRD42018060999). (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2018 Category: International Medicine & Public Health Source Type: research

Systematic review and meta-analysis of diagnostic accuracy of detection of any level of diabetic retinopathy using digital retinal imaging
ConclusionsNon-mydriatic two-field strategy could be a more pragmatic approach in starting DRS programmes for facility-based PwDM in low-income settings, with dilatation of the pupils of those who have ungradable images. There was insufficient evidence in primary studies to draw firm conclusions on how graders ’ background influences DTA. Conducting more context-specific DRS validation studies in low-income and non-ophthalmic settings can be recommended. (Source: Systematic Reviews)
Source: Systematic Reviews - November 7, 2018 Category: International Medicine & Public Health Source Type: research

Measures assessing attributes of evidence-informed decision-making (EIDM) competence among nurses: a systematic review protocol
DiscussionThis systematic review will provide a current understanding about the state of evidence with respect to EIDM competence measures in nursing to assist in determining potentially relevant and robust measures for use in different nursing practice settings.Systematic review registrationProtocol registered in PROSPERO Registration #:CRD42018088754 (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2018 Category: International Medicine & Public Health Source Type: research

Parent-to-parent support interventions for parents of babies cared for in a neonatal unit —protocol of a systematic review of qualitative and quantitative evidence
DiscussionAll outputs will be available on the NIHR CLAHRC South West Peninsula (PenCLAHRC) website and promoted via PenCLAHRC networks as well as organisations that have been contacted throughout the project. PAG members will be involved in writing and reviewing the academic paper and final report and in co-producing dissemination products such as plain language summaries. The PAG will influence the main conclusions of the systematic review, aid interpretation and help to communicate results in the most appropriate ways. We will hold an impact conference with representatives from neonatal units, national neonatal networks...
Source: Systematic Reviews - October 31, 2018 Category: International Medicine & Public Health Source Type: research

Effects of perioperative fluid management on postoperative outcomes in liver transplantation: a systematic review protocol
DiscussionHuman organs available for transplantation are scarce resources. Strategies to improve recipients ’ survival are needed. We hypothesize that restrictive fluid management strategies will be associated with better postoperative outcomes than liberal fluid management strategies. This systematic review will improve our understanding of the available evidence and help us better inform future clinic al trials.Systematic review registrationThis systematic review protocol is registered in PROSPERO (CRD42017054970). (Source: Systematic Reviews)
Source: Systematic Reviews - October 31, 2018 Category: International Medicine & Public Health Source Type: research

Does motivational interviewing improve the weight management process in adolescents? Protocol for a systematic review and meta-analysis
This study aims to investigate whether MI will improve weight management process in adolescents.Methods/designA systematic review will be conducted on clinical trials, assessing the effect of MI on weight management processes in adolescents, aged 10 to 19  years. The primary objective is to assess the efficacy of MI in controlling weight-related measures in overweight and obese adolescents. Secondary objectives are assessing the efficacy of MI on obesity-related behaviors and cognitive abilities considering heterogeneity in outcomes of primary studi es in different MI settings. Main data sources include MEDLINE/PubMed...
Source: Systematic Reviews - October 30, 2018 Category: International Medicine & Public Health Source Type: research

Physical activity participation and the risk of chronic diseases among South Asian adults: protocol for a systematic review and meta-analysis
DiscussionThis review will summarise the strength of the association between physical activity and selected chronic diseases and their markers among South Asian adults 40  years or older. The findings will provide an evidence base to guide public health policy and interventions in the South Asian region and to inform future research to address the rising burden of chronic diseases.Systematic review registrationPROSPEROCRD42018096505 (Source: Systematic Reviews)
Source: Systematic Reviews - October 30, 2018 Category: International Medicine & Public Health Source Type: research

Functional, motor, and sensory assessment instruments upon nerve repair in adult hands: systematic review of psychometric properties
ConclusionsFew studies included nerve repair in their sample for the psychometric analysis of outcome measures, so moderate evidence could be confirmed. Manual muscle test and Rotterdam Intrinsic Hand Myometer dynamometer had excellent reliability but insufficient data on validity or responsiveness. Touch threshold testing was more responsive than 2PD test. The locognosia test and STI had limited but positive supporting data related to validity. Ros én-Lundborg score had emerging evidence of reliability and validity as a comprehensive outcome following nerve repair. Few questionnaires were considered reliable and va...
Source: Systematic Reviews - October 27, 2018 Category: International Medicine & Public Health Source Type: research

Partially systematic thoughts on the history of systematic reviews
AbstractSix years after the launch ofSystematic Reviews by Biomed Central, this article is part of the celebration of the journal. It contains personal reflections on the past, present and future of systematic reviews, using examples relevant to the role of systematic reviews in cataloguing and analysing research, assessing quality and planning new studies. The focus is on the most common of the various types of systematic review in health and social care, namely those assessing the effects of interventions. (Source: Systematic Reviews)
Source: Systematic Reviews - October 27, 2018 Category: International Medicine & Public Health Source Type: research

Protocol of a systematic review on the application of wearable inertial sensors to quantify everyday life motor activity in people with mobility impairments
DiscussionThis review will facilitate the selection of an appropriate sensor setup for future applications, contain recommendations about the design of data processing algorithms as well as their evaluation procedure, and present a gap for innovative, new algorithms, and devices.Systematic review registrationInternational prospective register of systematic reviews (PROSPERO):CRD42017069865. (Source: Systematic Reviews)
Source: Systematic Reviews - October 24, 2018 Category: International Medicine & Public Health Source Type: research

A study of the value of requesting information from drug manufacturers for systematic reviews; 9 years of experience from the drug effectiveness review project
ConclusionsIn SRs conducted for DERP, few studies submitted by pharmaceutical manufacturers were ultimately included in a SR. The included data helped to reduce reporting and publication bias by filling important gaps and in some cases led to altered conclusions. (Source: Systematic Reviews)
Source: Systematic Reviews - October 22, 2018 Category: International Medicine & Public Health Source Type: research

The impact of body mass index on mortality in patients with acute kidney injury: a systematic review protocol
DiscussionBody mass index may be an important modifiable risk factor for mortality in patients presenting with AKI. The proposed systematic review will help to elucidate the association between all categories of BMI and survival in this patient group.Systematic review registrationPROSPEROCRD42017071124. (Source: Systematic Reviews)
Source: Systematic Reviews - October 22, 2018 Category: International Medicine & Public Health Source Type: research

Effects of hypercapnia in sepsis: protocol for a systematic review of clinical and preclinical data
The objective of this systematic review is to collate the biomedical literature of preclinical and clinical studies testing the effects of higher PaCO2 levels in the setting of sepsis.MethodsWe will perform a qualitative systematic review of preclinical and clinical studies evaluating the effects of hypercapnia in sepsis. We will search CENTRAL, PubMed, CINAHL, and EMBASE using a comprehensive strategy. We will screen the reference lists of the articles we select for inclusion to identify additional studies for potential inclusion. Two independent reviewers will review all search results. Upon inclusion of articles, we wil...
Source: Systematic Reviews - October 22, 2018 Category: International Medicine & Public Health Source Type: research

Rapid methods including network meta-analysis to produce evidence in clinical decision support: a decision analysis
ConclusionsThe transfer of knowledge to practice could benefit from faster systematic reviewing methods. The results in this preliminary assessment suggest that an improved rapid NMA approach might replace gold standard NMAs. Decision analysis could be used to compare evidence summarisation methods. (Source: Systematic Reviews)
Source: Systematic Reviews - October 20, 2018 Category: International Medicine & Public Health Source Type: research

Prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients associated with oral anticoagulant administration: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
DiscussionAs critical bleeding in patients treated with oral anticoagulants is an increasing problem, an up-to-date systematic review evaluating the benefits and harms of prothrombin complex concentrate is urgently needed. It is the hope that this review will be able to guide best practice in treatment and clinical research of these critically bleeding patients.Systematic review registrationPROSPERO CRD42018084371 (Source: Systematic Reviews)
Source: Systematic Reviews - October 20, 2018 Category: International Medicine & Public Health Source Type: research

T cell activation and cardiovascular risk in type 2 diabetes mellitus: a protocol for a systematic review and meta-analysis
DiscussionsThis review will not require ethical approval, and the findings will be disseminated through peer-reviewed publication and conferences. Although other previous studies have reported deregulated T cell function in hyperglycaemia, the underlying mechanisms remain controversial. However, evidence suggests that T cells may be a key component in the development of T2DM and CVDs as its complication. Furthermore, they are a potential diagnostic and therapeutic target in the management of the disease.Systematic review registrationPROSPEROCRD42018099745 (Source: Systematic Reviews)
Source: Systematic Reviews - October 20, 2018 Category: International Medicine & Public Health Source Type: research

The effect of carbetocin compared to misoprostol in management of the third stage of labor and prevention of postpartum hemorrhage: a systematic review
ConclusionAlthough this review showed that carbetocin is effective for decreasing PPH, blood loss, the length of the third stage of labor, and the need for additional uterotonics, this conclusion should be considered with caution. Because assessment of PPH is a subjective issue and it is uncertain whether outcomes were assessed blindly in respect to treatment. We recommend future research to verify our findings. Also clinicians may like to consider use of carbetocin for women with low risk for PPH. (Source: Systematic Reviews)
Source: Systematic Reviews - October 20, 2018 Category: International Medicine & Public Health Source Type: research

Effective study selection using text mining or a single-screening approach: a study protocol
This study is also the first to investigate a range of questions surrounding the screening process and to include an a priori sample size calculation, thus enabling statistical conclusions. In addition, the impact of missing studies on the conclusion of a benefit assessment is calculated.Systematic review registrationNot applicable (Source: Systematic Reviews)
Source: Systematic Reviews - October 20, 2018 Category: International Medicine & Public Health Source Type: research

The impact of health literacy on diagnosis and outcomes of symptomatic cancer by ethnicity : a systematic review protocol
DiscussionThis systematic review will summarise the evidence regarding ethnic inequality in health literacy and how this impacts on diagnosis and outcomes of cancer. The review will identify possible areas for future research, and inform clinical practice and interventions to reduce ethnic inequalities in cancer diagnosis and outcomes. (Source: Systematic Reviews)
Source: Systematic Reviews - October 17, 2018 Category: International Medicine & Public Health Source Type: research

The use of probiotics for improving lipid profiles in dyslipidemic individuals: an overview protocol
DiscussionThere are some systematic reviews about the use of probiotics to prevent and/or treat dyslipidemia; however, their outcomes related to the ability of probiotics to improve lipid profiles are conflicting. So, an overview on this topic is needed to clarify this important issue.Systematic review registrationPROSPEROCRD42017080328 (Source: Systematic Reviews)
Source: Systematic Reviews - October 17, 2018 Category: International Medicine & Public Health Source Type: research

The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol
DiscussionThis systematic review aims to clarify whether BPV is associated with elevated risk for dementia, cognitive impairment, and cognitive function. An evaluation of the etiological links between BPV with incident dementia might inform evidence-based clinical practice and policy concerning blood pressure measurement and hypertension management. The review will identify sources of heterogeneity and may inform decisions on whether it is feasible and desirable to proceed with an individual participant data meta-analysis.Systematic review registrationPROSPEROCRD42017081977 (Source: Systematic Reviews)
Source: Systematic Reviews - October 15, 2018 Category: International Medicine & Public Health Source Type: research

Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis
ConclusionsThe results suggest that DM can significantly increase the odds of developing MDR-TB. Consequently, a more robust TB treatment and follow-up might be necessary for patients with DM. Efforts to control DM can have a substantial beneficial effect on TB outcomes, particularly in the case of MDR-TB.Systematic review registrationPROSPEROCRD42016045692. (Source: Systematic Reviews)
Source: Systematic Reviews - October 15, 2018 Category: International Medicine & Public Health Source Type: research

Joint distraction for knee osteoarthritis: protocol for a systematic review and meta-analysis
DiscussionThis systematic review will summarise the short- and long-term clinical and structural outcomes following joint distraction for knee osteoarthritis. The findings from this review will establish the quality of currently available evidence, which will determine the need for further studies to establish the true effect size of this procedure.Systematic review registrationPROSPEROCRD42018087032 (Source: Systematic Reviews)
Source: Systematic Reviews - October 15, 2018 Category: International Medicine & Public Health Source Type: research

The effectiveness of attentional bias modification for substance use disorder symptoms in adults: a systematic review
ConclusionsDespite a number of negative findings and the diversity of studies, multi-session ABM interventions, especially in the case of alcohol and when the Alcohol Attention Control Training Programme was used, appear to have positive effects on symptoms of addictive behaviour. However, more rigorous well-powered future research in clinical samples is needed before firm conclusions regarding the effectiveness of ABM interventions can be drawn.Systematic review registrationRegistration number PROSPERO:CRD42016046823 (Source: Systematic Reviews)
Source: Systematic Reviews - October 13, 2018 Category: International Medicine & Public Health Source Type: research

Toward a comprehensive evidence map of overview of systematic review methods: paper 2 —risk of bias assessment; synthesis, presentation and summary of the findings; and assessment of the certainty of the evidence
ConclusionMany methods have been described for use in the latter steps in conducting an overview; however, evaluation and guidance for applying these methods is sparse. The exception is RoB assessment, for which a multitude of tools exist —several with sufficient evaluation and guidance to recommend their use. Evaluation of other methods is required to provide a comprehensive evidence map. (Source: Systematic Reviews)
Source: Systematic Reviews - October 12, 2018 Category: International Medicine & Public Health Source Type: research