Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis—systematic review protocol
Discussion Benefits and harms of pharmacological treatment in erythema migrans have not yet been adequately assessed. This systematic review will evaluate and summarise available evidence addressing benefits and harms of different pharmacological treatments. In addition, this summary of clinical evidence will inform decision-making between clinicians and patients and will play an important part in patient care. Systematic review registration PROSPERO: CRD42016037932 (Source: Systematic Reviews)
Source: Systematic Reviews - May 3, 2016 Category: Global & Universal Source Type: research

The range of peripapillary retinal nerve fibre layer and optic disc parameters in children aged up to but not including 18 years of age, as measured by optical coherence tomography: protocol for a systematic review
Discussion This review aims to provide an overview of the parameters of the optic disc and pRNFL in children of different ages in order to identify gaps in knowledge and to improve understanding of what might be considered within/outside the range of normality. The findings will be presented in peer-reviewed journals and will be presented at conferences. Systematic review registration PROSPERO CRD42016033068 (Source: Systematic Reviews)
Source: Systematic Reviews - April 30, 2016 Category: Global & Universal Source Type: research

To what extent do site-based training, mentoring, and operational research improve district health system management and leadership in low- and middle-income countries: a systematic review protocol
Discussion This protocol paper describes a systematic review assessing the effectiveness of site-based training (with or without mentoring programmes or operational research) on the improvement of district health system management and leadership. Systematic review registration PROSPERO CRD42015032351 (Source: Systematic Reviews)
Source: Systematic Reviews - April 27, 2016 Category: Global & Universal Source Type: research

Erratum to: Nonpharmacologic, nonherbal management of menopause-associated vasomotor symptoms: an umbrella systematic review (protocol)
(Source: Systematic Reviews)
Source: Systematic Reviews - April 25, 2016 Category: Global & Universal Source Type: research

The effectiveness of peer mentoring in promoting a positive transition to higher education for first-year undergraduate students: a mixed methods systematic review protocol
Discussion The review will provide clear, non-biased evidence-based guidance to all third-level educators on the effectiveness of peer-mentoring programmes for first-year undergraduates. The review is necessary to help establish which type of peer mentoring is most effective. The evidence from qualitative and quantitative studies drawn from the international literature will be utilised to illustrate the best way to implement and evaluate peer mentoring as an effective intervention and will be useful in guiding future research and practice in this area. These findings may be applied internationally across all dis...
Source: Systematic Reviews - April 22, 2016 Category: Global & Universal Source Type: research

Concurrent use of prescription drugs and herbal medicinal products in older adults: a systematic review protocol
Discussion This review will synthesise and critically appraise current knowledge on the concurrent use of drugs and HMPs by older adults and thus provide a better understanding of the issue. It will also identify any gaps in knowledge. By establishing safety issues associated with concurrent use, it will also inform strategies that can help practitioners to identify and manage older people at potential risk of herb-drug interactions. Systematic review registration PROSPERO CRD42014009091 (Source: Systematic Reviews)
Source: Systematic Reviews - April 21, 2016 Category: Global & Universal Source Type: research

Regional versus general anaesthesia in elderly patients undergoing surgery for hip fracture: protocol for a systematic review
Discussion This systematic review will provide an updated evidence base with which to guide clinical practice and research for this group of challenging patients. If the anaesthetic technique employed is shown to reduce the incidence of post-operative cognition dysfunction, then this may lead to a change in evidence-based practice, influence future guidelines and support further randomised controlled trial research. There is no known effective treatment for delirium, creating the urgent need for research into delirium prevention. Systematic review registration PROSPERO...
Source: Systematic Reviews - April 21, 2016 Category: Global & Universal Source Type: research

Increasing the uptake of exercise programs in the dialysis unit: a protocol for a realist synthesis
Discussion The complexity of intradialytic exercise programs poses challenges to their implementation. Using the “context, mechanism, outcome” approach, the knowledge gained from this study will be used to develop general recommendations for renal care providers and administration on how to adapt components of an intradialytic exercise programs according to different contextual factors in order to promote patient participation. Systematic review registration PROSPERO CRD42016033335 (Source: Systematic Reviews)
Source: Systematic Reviews - April 21, 2016 Category: Global & Universal Source Type: research

Delivery of health care for cardiovascular and metabolic diseases among people living with HIV/AIDS in African countries: a systematic review protocol
We present a systematic review protocol to synthesize studies of healthcare delivery for an important subset of NCDs, cardiovascular and metabolic diseases (CMDs), among African PLHIV. Methods/design We plan to search electronic databases and reference lists of relevant studies published in African settings from January 2003 to the present. Studies will be considered if they address one or both of our major objectives and focus on health care for one or more of six interrelated CMDs (ischemic heart disease, stroke, heart failure, hypertension, diabetes, and hyperlipidemia) in PLH...
Source: Systematic Reviews - April 16, 2016 Category: Global & Universal Source Type: research

International law’s effects on health and its social determinants: protocol for a systematic review, meta-analysis, and meta-regression analysis
Discussion The findings of this review will contribute to a better understanding of the expected benefits and possible harms of using international law to address different kinds of problems, thereby providing important evidence-informed guidance on when and how it can be effectively introduced and implemented by countries and global institutions. Systematic review registration PROSPERO CRD42015019830 (Source: Systematic Reviews)
Source: Systematic Reviews - April 16, 2016 Category: Global & Universal Source Type: research

Anticipatory and compensatory postural adjustments in people with low back pain: a protocol for a systematic review and meta-analysis
Discussion To our knowledge, this is the first systematic review to examine APAs and CPAs, as measured by EMG, COP, and kinematics in people with LBP. The findings of this review may aid in the identification of factors that play a role in the persistence of symptoms and disability and aid in the development of interventions to treat symptoms. Systematic review registration PROSPERO CRD42016032815 (Source: Systematic Reviews)
Source: Systematic Reviews - April 16, 2016 Category: Global & Universal Source Type: research

What factors affect evidence-informed policymaking in public health? Protocol for a systematic review of qualitative evidence using thematic synthesis
Discussion This review will be the most comprehensive to date to synthesise the qualitative literature on evidence use by public health policymakers and will be the first to apply a formal method of qualitative metasynthesis to this body of evidence. Its results will be useful both to scholars of evidence use and knowledge translation and to decision-makers and academics attempting to influence public health policy. (Source: Systematic Reviews)
Source: Systematic Reviews - April 14, 2016 Category: Global & Universal Source Type: research

Limitations of A Measurement Tool to Assess Systematic Reviews (AMSTAR) and suggestions for improvement
Abstract A Measurement Tool to Assess Systematic Reviews (AMSTAR) is a commonly used tool to assess the quality of systematic reviews; however, modifications are needed to improve its usability, reliability, and validity. In this commentary, we summarize our experience and the experiences of others who have used AMSTAR and provide suggestions for its improvement. We propose that AMSTAR should modify a number of individual items and their instructions and responses to make them more congruent with an assessment of the methodologic quality of systematic reviews. We recommend adding new items and modifying existing ...
Source: Systematic Reviews - April 12, 2016 Category: Global & Universal Source Type: research

Monoclonal antibody therapy for Kawasaki disease: a protocol for systematic reviews and meta-analysis
The objective of this study is to examine the effectiveness of treatment with monoclonal antibodies for KD patients. Methods Relevant randomized controlled trials (RCTs), cluster RCTs, quasi-RCTs, cross-over trials, and any observational studies (e.g., cohort studies, case-control studies, case series, and case reports) will be included to summarize available evidence both qualitatively and quantitatively. Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and ICUSHI will be searched. We will assess coronary artery and treatment outcomes of the interventions. Two au...
Source: Systematic Reviews - April 12, 2016 Category: Global & Universal Source Type: research

The effect of tailored Web-based interventions on pain in adults: a systematic review protocol
Discussion This systematic review is the first one looking at the specific ingredients and effects of tailored and Web-based interventions for pain management. Results of this systematic review could contribute to a better understanding of the mechanisms by which Web-based interventions could be helpful for people facing pain problems. Systematic review registration PROSPERO CRD42015027669 (Source: Systematic Reviews)
Source: Systematic Reviews - April 12, 2016 Category: Global & Universal Source Type: research

The effects of public health policies on population health and health inequalities in European welfare states: protocol for an umbrella review
Discussion Understanding the impact of specific public health policy interventions will help to establish causality in terms of the effects of welfare states on population health and health inequalities. The review will document contextual information on how population-level public health interventions are organised, implemented and delivered. This information can be used to identify effective interventions that could be implemented to reduce health inequalities between and within European countries. Systematic review registration PROSPERO CRD42016025283 (Source: Systematic Reviews)
Source: Systematic Reviews - April 8, 2016 Category: Global & Universal Source Type: research

Barriers and facilitators in providing oral health care to nursing home residents, from the perspective of care aides—a systematic review protocol
Discussion This review will advance the development of effective strategies for improving quality of oral health care and highlight gaps in research on barriers and facilitators to providing oral health care to nursing home residents, as perceived by care aides. Systematic review registration PROSPERO CRD42015032454 (Source: Systematic Reviews)
Source: Systematic Reviews - April 7, 2016 Category: Global & Universal Source Type: research

Supporting successful implementation of public health interventions: protocol for a realist synthesis
Discussion Developing new public health interventions is costly and policy windows that support their implementation can be short lived. Ineffective implementation wastes scarce resources and is neither affordable nor sustainable. Public health interventions that are not implemented will not have their intended effects on improving population health and promoting health equity. This synthesis will provide evidence to support effective implementation of public health interventions taking into account the variable context of interventions. A series of knowledge translation products specific to the needs of knowled...
Source: Systematic Reviews - April 7, 2016 Category: Global & Universal Source Type: research

Nonpharmacologic, nonherbal management of menopause-associated vasomotor symptoms: an umbrella systematic review (protocol)
We describe a protocol for an umbrella review approach, supplemented by evaluating randomized controlled trials (RCTs) published after the most recent good-quality systematic review for each of the eligible interventions. Specific interventions were chosen based on current literature and with input from a technical expert panel and organizational stakeholders. We will conduct a thorough literature search and perform a quality assessment of potentially included systematic reviews and RCTs. Discussion Our umbrella review, supplemented by an additional search for eligible RCTs, aims...
Source: Systematic Reviews - April 7, 2016 Category: Global & Universal Source Type: research

The effects of HIV self-testing on the uptake of HIV testing and linkage to antiretroviral treatment among adults in Africa: a systematic review protocol
Discussion Innovative and cost-effective community-based HIV testing strategies, such as self-testing, will contribute to universal coverage of HIV testing in Africa. The findings from this systematic review will guide development of self-testing policy in African countries. Systematic review registration PROSPERO CRD42015023935 (Source: Systematic Reviews)
Source: Systematic Reviews - April 5, 2016 Category: Global & Universal Source Type: research

Effects of mindfulness-based stress reduction for adults with sleep disturbance: a protocol for an update of a systematic review and meta-analysis
Discussion Many published primary studies have investigated the positive effects of MBSR on sleep quality; however, there are no systematic reviews and meta-analyses synthesizing the evidence of up-to-date research on the effects of MBSR for sleep problems. The review findings will aid the general population and healthcare providers in making informed decisions on evidence-based intervention selection for sleep disturbance or insomnia. Systematic review registration PROSPERO CRD42015027963. (Source: Systematic Reviews)
Source: Systematic Reviews - April 2, 2016 Category: Global & Universal Source Type: research

Insertion torque recordings for the diagnosis of contact between orthodontic mini-implants and dental roots: a systematic review
Conclusions All eligible studies scored higher insertion torque values for implants with root contact than those without, but none of these studies assessed the diagnostic accuracy of the index test. The inclusion of non-randomized and animal and cadaver models in this systematic review provided key findings that otherwise would have been wasted. Such studies are important in the context of the wide applicability of this test, the high prevalence of the target condition, and the underreporting of adverse effects of interventions. A protocol for a potential new diagnostic pathway was presented, and the importance...
Source: Systematic Reviews - March 31, 2016 Category: Global & Universal Source Type: research

The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol
Discussion This systematic review and meta-analysis will identify and synthesize evidence to determine if there is an association between central and peripheral OT concentrations. If significant associations are observed, evidence would provide a rationale for future research to use peripheral measures as a proxy for central OT concentrations. Systematic review registration PROSPERO CRD42015027864 (Source: Systematic Reviews)
Source: Systematic Reviews - March 31, 2016 Category: Global & Universal Source Type: research

Blinding in randomized controlled trials in general and abdominal surgery: protocol for a systematic review and empirical study
Discussion Detection and performance bias distort treatment effects. The degree of such bias in general and abdominal surgery is unknown. Evidence on influence of missing blinding would improve critical appraisal and conduct of general and abdominal surgery RCT. Systematic review registration PROSPERO 2015:CRD42015026837. (Source: Systematic Reviews)
Source: Systematic Reviews - March 24, 2016 Category: Global & Universal Source Type: research

Discharge interventions for older patients leaving hospital: protocol for a systematic meta-review
Discussion This review will identify existing reviews of discharge interventions and appraise how these interventions can impact outcomes in older people such as readmissions, health status, length of hospital stay and mortality. The review could inform practice and will help identify where further research is needed. Systematic review registration PROSPERO CRD42015025737. (Source: Systematic Reviews)
Source: Systematic Reviews - March 16, 2016 Category: Global & Universal Source Type: research

Effectiveness of eHealth interventions for the promotion of physical activity in older adults: a systematic review protocol
Discussion The proposed systematic review will be the first review that compares the effectiveness of eHealth interventions promoting PA in older adults aged 55 years and above with control groups exposed to a non-eHealth intervention or to no intervention. The results of this review will provide new information regarding the question whether eHealth interventions are an effective intervention vehicle for PA promotion in this population. Systematic review registration PROSPERO CRD42015023875 (Source: Systematic Reviews)
Source: Systematic Reviews - March 16, 2016 Category: Global & Universal Source Type: research

Why, when and how to update a meta-ethnography qualitative synthesis
Conclusions This article makes a unique contribution to this evolving area of meta-ethnography methodology. (Source: Systematic Reviews)
Source: Systematic Reviews - March 15, 2016 Category: Global & Universal Source Type: research

Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies
Abstract Background Previous studies showed that high dose of caffeine intake may induce some specific human reproductive system diseases, even lead to infertility. Objectives In consideration of the high consumption of caffeine according to the latest population-based survey, this review is aimed to systematically review the evidence from all controlled clinical studies of caffeine intake for infertility. Designs Relevant randomized/quasi-randomized controlled trials, non-randomized clinical studies, co...
Source: Systematic Reviews - March 15, 2016 Category: Global & Universal Source Type: research

Physical activity in advanced cancer patients: a systematic review protocol
Discussion This systematic review will summarize the current evidence base on physical activity interventions in advanced cancer patients. The findings from this systematic review will identify gaps to be explored by future research studies and inform future practice guideline development of physical activity interventions in advanced cancer patients. Systematic review registration PROSPERO CRD42015026281 (Source: Systematic Reviews)
Source: Systematic Reviews - March 11, 2016 Category: Global & Universal Source Type: research

An evaluation of psychometric properties of caregiver burden outcome measures used in caregivers of children with cerebral palsy: a systematic review protocol
Discussion The proposed systematic review will give an extensive review of the psychometrical properties of tools used to measure caregiver burden in caregivers of children with CP. We hope to identify tools that can be used to accurately screen for caregiver burden both in clinical setting and for research purposes. Systematic review registration PROSPERO CRD42015028026. (Source: Systematic Reviews)
Source: Systematic Reviews - March 9, 2016 Category: Global & Universal Source Type: research

Do Cochrane summaries help student midwives understand the findings of Cochrane systematic reviews: the BRIEF randomised trial
Conclusions Abstracts with and without conclusions generated similar student responses. PLS with conclusions gave similar results to abstracts with and without conclusions. Removing the conclusions from a PLS with uncertain findings led to more problems with interpretation. (Source: Systematic Reviews)
Source: Systematic Reviews - March 1, 2016 Category: Global & Universal Source Type: research

Health service provider education and/or training in infant male circumcision to improve short- and long-term morbidity outcomes: protocol for systematic review
Discussion This review appears to be the first to be conducted in this area. The findings will have important implications for infant male circumcision programmes and policy. Systematic review registration PROSPERO CRD42015029345 (Source: Systematic Reviews)
Source: Systematic Reviews - March 1, 2016 Category: Global & Universal Source Type: research

Comparing the coverage, recall, and precision of searches for 120 systematic reviews in Embase, MEDLINE, and Google Scholar: a prospective study
Conclusions Although overall coverage and recall of GS are high for many searches, the database does not achieve full coverage as some researchers found in previous research. Further, being able to view only the first 1000 records in GS severely reduces its recall percentages. If GS would enable the browsing of records beyond the first 1000, its recall would increase but not sufficiently to be used alone in SR searching. Time needed to screen results would also increase considerably. These results support our assertion that neither GS nor one of the other databases investigated, is on its own, an acceptable data...
Source: Systematic Reviews - March 1, 2016 Category: Global & Universal Source Type: research

The impact of perioperative red blood cell transfusions in patients undergoing liver resection: a systematic review protocol
The objective of this systematic review is to provide estimates of transfusion prevalence and the effects of perioperative blood transfusion on postoperative mortality and morbidity and long-term cancer outcomes in patients undergoing liver resection. Methods/design The Cochrane, Medline, and EMBASE databases will be searched for any randomized controlled trial or observational cohort study comparing liver resection patients that received intraoperative or postoperative allogeneic red blood cell transfusions to those who did not. Outcomes include postoperative mortality, postoper...
Source: Systematic Reviews - February 29, 2016 Category: Global & Universal Source Type: research

Educational interventions to improve people’s understanding of key concepts in assessing the effects of health interventions: a systematic review protocol
Abstract Background Health information has become readily accessible through mass media, and people are playing a more active and autonomous role in their health. Much of the health information that was previously only available to health professionals is now directly accessible to the public. Consequently, people often navigate vast amounts of health information on their own, typically with little knowledge about how to evaluate it or the need to do so. Health information remains essentially unregulated, and widespread problems and concerns with the quality of health information...
Source: Systematic Reviews - February 25, 2016 Category: Global & Universal Source Type: research

Thanks to all those who reviewed for Systematic Reviews in 2015
Contributing reviewers A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they are greatly facilitated by the deeper technical knowledge, scientific insights, understanding of social consequences, and passion that reviewers bring to our deliberations. For these reasons, the Editors-in-Chief and staff of Systematic Reviews warmly thank the 282 reviewers whose comments helped to shape the journal, for their invaluable assistance with review of manuscripts in Volume 4 (2015)....
Source: Systematic Reviews - February 24, 2016 Category: Global & Universal Source Type: research

Barriers and opportunities for return-to-work of cancer survivors: time for action—rapid review and expert consultation
Conclusions The awareness of health professionals regarding barriers of RTW may improve the early identification of cancer survivors at risk for prolonged time to RTW and may allow early supportive intervention. Social and employment policies should be better tailored to support both employers and cancer survivors in the RTW process, providing incentives to positively discriminate cancer survivors on prolonged sick leave. (Source: Systematic Reviews)
Source: Systematic Reviews - February 24, 2016 Category: Global & Universal Source Type: research

Association between physical performance and cardiovascular events in patients with coronary artery disease: protocol for a meta-analysis
Abstract Background Physical performance such as muscle strength or walking speed of patients with coronary artery disease (CAD) is lower than that of people who do not have CAD and is related to mortality and re-admission rates. Recent studies have shown that skeletal muscle strength, such as grip strength, was closely associated with cardiac events. Physical performance testing is quick, safe, and inexpensive and provides a reliable assessment tool for routine clinical practice. The aim of this meta-analysis is to clarify the association between physical performance testing and the risk o...
Source: Systematic Reviews - February 18, 2016 Category: Global & Universal Source Type: research

Using built-in functions of Adobe Acrobat Pro DC to help the selection process in systematic reviews of randomised trials
Abstract This letter describes a simple way of using Adobe Acrobat Pro DC to help select and auto-extract data from Portable Document Format (PDFs) of randomised trials in order to assist swift early selection of trials for a systematic review. (Source: Systematic Reviews)
Source: Systematic Reviews - February 18, 2016 Category: Global & Universal Source Type: research

Memory effects of sedative drugs in children and adolescents—protocol for a systematic review
Discussion To the best of our knowledge, there is no systematic review that specifically addresses this question. Findings from the review will be useful in the decision-making process about the best sedative for minimizing recall of the medical/dental event and possible psychological trauma. Systematic review registration PROSPERO CRD42015017559 (Source: Systematic Reviews)
Source: Systematic Reviews - February 18, 2016 Category: Global & Universal Source Type: research

Effective communication in eliciting and responding to suicidal thoughts: a systematic review protocol
Discussion The results of this systematic review will be used to guide training and practice for health care professionals. Systematic review registration PROSPERO CRD42015025867 (Source: Systematic Reviews)
Source: Systematic Reviews - February 17, 2016 Category: Global & Universal Source Type: research

Effectiveness of Internet- and mobile-based psychological interventions for the prevention of mental disorders: a systematic review and meta-analysis protocol
Discussion Prevention of mental disorders is one of the major emerging global health challenges. This review and meta-analysis will contribute to our understanding of the potential role for IMIs to help address this challenge. Systematic review registration PROSPERO CRD42015026781 (Source: Systematic Reviews)
Source: Systematic Reviews - February 16, 2016 Category: Global & Universal Source Type: research

The effectiveness of pharmacological agents for the treatment of uveitic macular oedema (UMO): a systematic review protocol
Discussion A number of published studies have investigated the effectiveness of the pharmacological agents used to treat UMO. However, there is no recent systematic review that synthesises this evidence. This systematic review will analyse the effectiveness of systemic, local and topical therapies to treat UMO. The findings will provide important evidence to inform clinical and health policy decision-making for the treatment of UMO. Systematic review registration Prospero CRD42015019170 (Source: Systematic Reviews)
Source: Systematic Reviews - February 13, 2016 Category: Global & Universal Source Type: research

What is an evidence map? A systematic review of published evidence maps and their definitions, methods, and products
Conclusions The principal conclusion of our evaluation of studies that call themselves “evidence maps” is that the implied definition of what constitutes an evidence map is a systematic search of a broad field to identify gaps in knowledge and/or future research needs that presents results in a user-friendly format, often a visual figure or graph, or a searchable database. Foundational work is needed to better standardize the methods and products of an evidence map so that researchers and policymakers will know what to expect of this new type of evidence review. Syste...
Source: Systematic Reviews - February 10, 2016 Category: Global & Universal Source Type: research

Measurement properties of quality of life measurement instruments for infants, children and adolescents with eczema: protocol for a systematic review
This study is a systematic review of the measurement properties of patient-reported measures of QoL developed and/or validated for infants, children, and adolescents with eczema. A systematic literature search will be carried out in MEDLINE via PubMed and EMBASE using a selection of relevant search terms. Eligible studies will be primary empirical studies evaluating, describing, or comparing measurement properties of QoL instruments for infants, children, and adolescents with eczema. Two reviewers will independently perform eligibility assessment and data abstraction. Evidence tables will be used to record study characteri...
Source: Systematic Reviews - February 9, 2016 Category: Global & Universal Source Type: research

A comparison of the performance of seven key bibliographic databases in identifying all relevant systematic reviews of interventions for hypertension
Conclusions The coverage of bibliographic databases varies considerably due to differences in their scope and content. Researchers wishing to identify systematic reviews should not rely on one database but search multiple databases. (Source: Systematic Reviews)
Source: Systematic Reviews - February 9, 2016 Category: Global & Universal Source Type: research

Thoracic dysfunction in whiplash-associated disorders: a systematic review and meta-analysis protocol
Discussion This is the first study to bring together evidence of thoracic dysfunction post whiplash and provide new insights into the scope and nature of thoracic dysfunction in WAD. With current management options being largely focused to a primary neck complaint and many patients going to become chronic in their presentations, this review may stimulate research and clinical interest in a largely under investigated, yet anatomically and kinematically related, spinal region. Systematic review registration PROSPERO CRD42015026983. (Source: Systematic Reviews)
Source: Systematic Reviews - February 9, 2016 Category: Global & Universal Source Type: research

The effect of early postnatal discharge from hospital for women and infants: a systematic review protocol
Discussion Information on the effects of early postnatal discharge from hospital will be important for policy makers and clinicians providing maternity care. This review will also identify any gaps in the current literature on this topic and provide direction for future research in this area of study. Systematic review registration PROSPERO CRD42015020545 (Source: Systematic Reviews)
Source: Systematic Reviews - February 8, 2016 Category: Global & Universal Source Type: research

Systematic review of depression in mild traumatic brain injury: study protocol
Discussion This will be the first systematic review conducted with the aim of describing the course, prognostic factors, and health-related outcomes of depression in adults who have suffered a mild traumatic brain injury. The findings of the planned systematic review have the potential to guide research and clinical practice to effectively develop and implement evidence-based interventions aimed at preventing and alleviating mild traumatic brain injury-related depression. Systematic review registration PROSPERO CRD42015019214 (Source: Systematic Reviews)
Source: Systematic Reviews - February 6, 2016 Category: Global & Universal Source Type: research

Barriers and facilitators to the implementation of orthodontic mini-implants in clinical practice: a protocol for a systematic review and meta-analysis
Discussion Knowledge creation on this research topic could identify and quantify both expected and unexpected implementation constructs and their stakeholders. Such knowledge can help develop strategies to address implementation issues and redirect future studies on OMIs towards knowledge translation. This could lead to improved patient-health experiences and a reduction in research waste. (Source: Systematic Reviews)
Source: Systematic Reviews - February 5, 2016 Category: Global & Universal Source Type: research