Anti-IgE monoclonal antibody therapy for the treatment of chronic rhinosinusitis: a systematic review
Abstract Background Several options are available for the treatment of chronic rhinosinusitis (CRS), but disease control remains elusive for many patients. Recently, literature has emerged describing anti-IgE monoclonal antibody as a potential therapy for CRS. However, its effectiveness and safety are not well known. The purpose of this systematic review was to assess the effectiveness and safety of anti-IgE therapy and to identify evidence gaps that will guide future research for the management of CRS. Methods Methodology was registered with PROS...
Source: Systematic Reviews - November 18, 2015 Category: Global & Universal Source Type: research

The risk of intra-cranial haemorrhage in those presenting late to the ED following a head injury: a systematic review
Conclusions Available evidence suggests that head injury patients who present in a delayed fashion to the ED may have lower rates of intra-cranial injury compared to non-delayed head injury patients. However, the evidence is sparse and it is of too low quality to guide clinical practice. Further research is required to help the clinical risk assessment of this group. Trial registration PROSPERO: CRD42015016135 (Source: Systematic Reviews)
Source: Systematic Reviews - November 18, 2015 Category: Global & Universal Source Type: research

Do alternative methods for analysing count data produce similar estimates? Implications for meta-analyses
Conclusions Information about the differences in treatments is lost when event rates increase and the outcome is dichotomised or time to the first event is analysed otherwise similar results are obtained. Further research is needed to examine the effect of differing variances from the different methods on the confidence intervals of pooled estimates. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2015 Category: Global & Universal Source Type: research

Systematic review of the use of behaviour change techniques (BCTs) in home-based cardiac rehabilitation programmes for patients with cardiovascular disease—protocol
Discussion This review will be of value to clinicians and healthcare professionals working with cardiovascular patients by identifying specific BCTs which are used within effective home-based CR. It will also inform the future design and evaluation of complex health service interventions aimed at secondary prevention in CVD. Systematic review registration PROSPERO registration CRD42015027036. (Source: Systematic Reviews)
Source: Systematic Reviews - November 17, 2015 Category: Global & Universal Source Type: research

Fluid strategies and outcomes in patients with acute respiratory distress syndrome, systemic inflammatory response syndrome and sepsis: a protocol for a systematic review and meta-analysis
Discussion While fluid management has been extensively studied and discussed in the critical care literature, no systematic review has attempted to summarise the evidence for post-resuscitation fluid strategies in critical illness. Results of the proposed systematic review will inform practice and the design of future clinical trials. Systematic review registration PROSPERO CRD42013005608. (http://www.crd.york.ac.uk/PROSPERO/) (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2015 Category: Global & Universal Source Type: research

Protocol for systematic review of evidence on the determinants and influence of early glycaemic control in childhood-onset type 1 diabetes
Discussion These linked reviews will be the first to systematically investigate the effects of early glycaemic control and integrate both the quantitative and qualitative evidence on predictors of early glycaemic control in childhood-onset T1D in reducing future diabetes complications. This will help identify and map current research and inform development of effective future interventions. Systematic review registration PROSPERO CRD42015024546 (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2015 Category: Global & Universal Source Type: research

Pre-clinical evaluation of therapies to prevent or treat bone non-union: a systematic review protocol
Discussion To date, there has not been a systematic review addressing bone non-union therapies in animal models despite the plethora of pre-clinical research currently being undertaken. This protocol details and outlines the methodology and justification for such a review. (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2015 Category: Global & Universal Source Type: research

Quality and performance measures of strain on intensive care capacity: a protocol for a systematic review
Discussion Our systematic review will comprehensively identify, define, and evaluate quality and performance measures of ICU capacity strain. This is a necessary step towards understanding the impact of capacity strain on quality and performance in intensive care and to develop innovative interventions aimed to improve efficiency, avoid waste, and better anticipate impending capacity shortfalls. Systematic review registration PROSPERO, CRD42015017931 (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2015 Category: Global & Universal Source Type: research

How to conduct systematic reviews more expeditiously?
Abstract Healthcare consumers, researchers, patients and policy makers increasingly use systematic reviews (SRs) to aid their decision-making process. However, the conduct of SRs can be a time-consuming and resource-intensive task. Often, clinical practice guideline developers or other decision-makers need to make informed decisions in a timely fashion (e.g. outbreaks of infection, hospital-based health technology assessments). Possible approaches to address the issue of timeliness in the production of SRs are to (a) implement process parallelisation, (b) adapt and apply innovative technologies, and/or (c) m...
Source: Systematic Reviews - November 12, 2015 Category: Global & Universal Source Type: research

Identifying and recruiting smokers for preoperative smoking cessation—a systematic review of methods reported in published studies
Conclusions Published studies often inadequately described the methods for recruiting smokers into preoperative smoking cessation programmes. Although smoking cessation at any time is beneficial, many programmes recruited smokers at times very close to scheduled surgery so that the benefit of preoperative smoking cessation may have not been fully effected. Optimal delivery of preoperative smoking cessation remains challenging, and further research is required to develop effective preoperative cessation programmes for smokers awaiting elective operations. (Source: Systematic Reviews)
Source: Systematic Reviews - November 11, 2015 Category: Global & Universal Source Type: research

Fidelity to and comparative results across behavioral interventions evaluated through the RE-AIM framework: a systematic review
Conclusions The RE-AIM framework has been employed in a variety of populations and settings for the planning, delivery, and evaluation of behavioral interventions. This review highlights inconsistencies in the degree to which authors reported each dimension in its entirety as well as inaccuracies in reporting indicators within each dimension. Further, there are few interventions that aim to improve outcomes related to reach, adoption, implementation, and maintenance. (Source: Systematic Reviews)
Source: Systematic Reviews - November 8, 2015 Category: Global & Universal Source Type: research

Nebulised dornase alfa versus placebo or hypertonic saline in adult critically ill patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
Conclusions We found very low quantity and quality of evidence for use of nebulised dornase alfa in adult critically ill patients in this systematic review with meta-analysis. Systematic review registration The International Prospective Register of Systematic Reviews (PROSPERO), no. CRD442015016047. (Source: Systematic Reviews)
Source: Systematic Reviews - November 8, 2015 Category: Global & Universal Source Type: research

Use of ward closure to control outbreaks among hospitalized patients in acute care settings: a systematic review
Conclusions With no published controlled studies identified, ward closure for control of outbreaks remains an intervention that is not evidence based and healthcare personnel will need to continue to balance the competing risks associated with its use, taking into consideration the nature of the outbreak, the type of pathogen and its virulence, mode of transmission, and the setting in which it occurs. Our review has identified a major research gap in this area. (Source: Systematic Reviews)
Source: Systematic Reviews - November 7, 2015 Category: Global & Universal Source Type: research

Key components in models of community-based interventions coordinating care in dementia: a mixed studies systematic review protocol
Discussion The results from this review will be used to develop a model for a community-based intervention coordinating care in dementia. Furthermore, the findings will help guide future work on intervention development of health and social care services for dementia. Systematic review registration PROSPERO CRD42015024618 (Source: Systematic Reviews)
Source: Systematic Reviews - November 7, 2015 Category: Global & Universal Source Type: research

Protocol for a systematic review of quantitative burn wound microbiology in the management of burns patients
Discussion Given the increasing use of quantitative methods, this is a timely systematic review, which will attempt to clarify the evidence base. As far as the authors are aware, it will be the first to address this topic. Trial registration PROSPERO, CRD42015023903 (Source: Systematic Reviews)
Source: Systematic Reviews - November 6, 2015 Category: Global & Universal Source Type: research

Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol)
Discussion The aim of this systematic review is to summarize the evidence on the efficacy and safety of clonidine as a sedative agent in the critically ill population. Systematic review registration PROSPERO CRD42015019365. (Source: Systematic Reviews)
Source: Systematic Reviews - November 6, 2015 Category: Global & Universal Source Type: research

Adherence to Brain Trauma Foundation guidelines for management of traumatic brain injury patients: study protocol for a systematic review and meta-analysis
This study is expected to demonstrate the current level of professionals’ adherence to BTF guidelines in patients with severe traumatic brain injury, it will describe the factors influencing adherence, which may provide valuable input for development of strategies to successfully increase adherence. In addition, if the studies are sufficiently homogenous, it will describe the effect of these guidelines on patient outcome. Systematic review registration PROSPERO CRD42015017794 (Source: Systematic Reviews)
Source: Systematic Reviews - November 5, 2015 Category: Global & Universal Source Type: research

Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities
Abstract Network meta-analysis is increasingly used to allow comparison of multiple treatment alternatives simultaneously, some of which may not have been compared directly in primary research studies. The majority of network meta-analyses published to date have incorporated data from randomized controlled trials (RCTs) only; however, inclusion of non-randomized studies may sometimes be considered. Non-randomized studies can complement RCTs or address some of their limitations, such as short follow-up time, small sample size, highly selected population, high cost, and ethical restrictions. In this paper, we discu...
Source: Systematic Reviews - November 5, 2015 Category: Global & Universal Source Type: research

Identifying the content of home-based health behaviour change interventions for frail older people: a systematic review protocol
Discussion Results will reveal the strategies that have been drawn on within home-based interventions to modify the health behaviours of frail older people, and highlight those more associated with positive changes in behaviour and health. Findings from this review will provide a useful basis for understanding, developing, and implementing behaviour change interventions in this field. Systematic review registration PROSPERO CRD42014010370 (Source: Systematic Reviews)
Source: Systematic Reviews - November 4, 2015 Category: Global & Universal Source Type: research

Involving people with diabetes and the wider community in diabetes research: a realist review protocol
Abstract Background Patient and public involvement in diabetes research is now actively encouraged in different countries because it is believed that involving people with experience of the condition will improve the quality and relevance of the research. However, reviews of patient involvement have noted that inadequate resources, patients’ and communities’ lack of research knowledge, and researchers’ lack of skills to involve patients and communities in research may present significant contextual barriers. Little is known about the extent of patient/community involvement...
Source: Systematic Reviews - November 4, 2015 Category: Global & Universal Source Type: research

The effectiveness of interventions to improve uptake and retention of HIV-infected pregnant and breastfeeding women and their infants in prevention of mother-to-child transmission care programs in low- and middle-income countries: protocol for a systematic review and meta-analysis
Discussion Our findings will be useful to PMTCT implementers, policy makers, and implementation researchers working in LMICs. Systematic review registration PROSPERO CRD42015020829 (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2015 Category: Global & Universal Source Type: research

The effects of culture on guideline discordant gestational weight gain: a systematic review protocol
Discussion This review will provide a comprehensive assessment and synthesis of current evidence and will draw attention to potential gaps where future research on the effects of culture on guideline discordant gestational weight gain remains to be conducted. Systematic review registration PROSPERO CRD42015023399 (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2015 Category: Global & Universal Source Type: research

Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol for a systematic review
Abstract Background Systematic reviews should provide trustworthy guidance to decision-makers, but their credibility is challenged by the selective reporting of trial results and outcomes. Some trials are not published, and even among clinical trials that are published partially (e.g., as conference abstracts), many are never published in full. Although there are many potential sources of published and unpublished data for systematic reviews, there are no established methods for choosing among multiple reports or data sources about the same trial. Methods ...
Source: Systematic Reviews - November 2, 2015 Category: Global & Universal Source Type: research

A protocol for a systematic review of the diagnostic accuracy of blood markers, synovial fluid, and tissue testing in periprosthetic joint infections (PJI)
Discussion We will conduct a systemic review of tests (blood markers, synovial fluids, and tissue testing) for diagnosing PJI in patients’ knee, hip, and shoulder joint replacements. This will be the first scientifically rigorous and comprehensive systematic review in the field and may feed into an evidence-based clinical practice guideline. We will compare the findings of this review with the consensus-based guides and discuss the differences, similarities, and knowledge gaps. Systematic review registration PROSPERO CRD42015023768 (Source: Systematic Reviews)
Source: Systematic Reviews - November 2, 2015 Category: Global & Universal Source Type: research

Effect of stigma reduction intervention strategies on HIV test uptake in low- and middle-income countries: a realist review protocol
Discussion This will be the first realist review that offers both a quantitative and a qualitative exploration of the available evidence to develop and propose a theoretical framework that explains why and how HIV stigma reduction intervention strategies influence HIV test uptake in low- and middle-income countries. Our theoretical framework is meant to provide guidance to program managers on identifying the most effective stigma reduction intervention strategies to increase HIV test uptake. We also include advice on how to effectively implement these strategies to reduce the rate of HIV transmission. ...
Source: Systematic Reviews - November 2, 2015 Category: Global & Universal Source Type: research

Hard-to-reach populations of men who have sex with men and sex workers: a systematic review on sampling methods
Abstract Background In public health, hard-to-reach populations are often recruited by non-probabilistic sampling methods that produce biased results. In order to overcome this, several sampling methods have been improved and developed in the last years. The aim of this systematic review was to identify all current methods used to survey most-at-risk populations of men who have sex with men and sex workers. The review also aimed to assess if there were any relations between the study populations and the sampling methods used to recruit them. Lastly, we wanted to assess if the number of publ...
Source: Systematic Reviews - October 30, 2015 Category: Global & Universal Source Type: research

Intervention Component Analysis (ICA): a pragmatic approach for identifying the critical features of complex interventions
Conclusions ICA is a formal and rigorous yet relatively streamlined approach to identify key intervention content and implementation processes. ICA addresses a critical need for knowledge translation around complex interventions to support policy decisions and evidence implementation. (Source: Systematic Reviews)
Source: Systematic Reviews - October 29, 2015 Category: Global & Universal Source Type: research

The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol
Discussion This review will synthesise evidence for the efficacy of discontinuing diuretics, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/direct renin inhibitors, NSAIDs, metformin or sulfonylureas to prevent or delay onset of AKI or associated complications. Results will provide guidance on efficacy and safety of this strategy and potentially help to develop an intervention to test the best mechanism of guiding medication discontinuation in at-risk populations. Systematic review registration PROSPERO CRD42015023210 (Source: Systematic Reviews)
Source: Systematic Reviews - October 24, 2015 Category: Global & Universal Source Type: research

Applying systematic review search methods to the grey literature: a case study examining guidelines for school-based breakfast programs in Canada
Conclusions This article demonstrated a feasible and seemingly robust method for applying systematic search strategies to identify web-based resources in the grey literature. The search strategy we developed and tested is amenable to adaptation to identify other types of grey literature from other disciplines and answering a wide range of research questions. This method should be further adapted and tested in future research syntheses. (Source: Systematic Reviews)
Source: Systematic Reviews - October 22, 2015 Category: Global & Universal Source Type: research

Considerations from the risk of bias perspective for updating Cochrane reviews
Abstract Authors of Cochrane reviews are expected to update their reviews every 2 years. The updating process helps to ensure that reviews are current and include recent evidence. However, the updating process is time-consuming for authors, particularly when Cochrane methods evolve and authors are required to revisit some of the originally included studies. The Cochrane Collaboration's ‘Risk of bias’ tool is a mandatory component of Cochrane reviews, providing an assessment of the potential biases of included studies. The tool has been modified most recently in 2011, and the expectation...
Source: Systematic Reviews - October 6, 2015 Category: Global & Universal Source Type: research

Protocol for a systematic review of the impact of resuscitation fluids on the microcirculation after haemorrhagic shock in animal models
Discussion The choice of type, sequence, and quantity of resuscitation fluid following haemorrhagic shock is controversial, and the optimal strategy for restoration of microcirculatory function is yet unknown. A detailed examination of pre-clinical data regarding the microcirculation is timely and will enable a focussed approach to clinical research for the improvement of resuscitation following haemorrhagic shock. Systematic review registration Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Studies (CAMARADES) (Source: Systematic Reviews)
Source: Systematic Reviews - October 5, 2015 Category: Global & Universal Source Type: research

Effects of education to facilitate knowledge about chronic pain for adults: a systematic review with meta-analysis
Conclusions The evidence base is limited by the small numbers of studies, their relatively small sample sizes, and the diversity in types of education studied. From that limited evidence, the only support for this type of education is for PNE, though it is insufficiently strong to recommend conclusively that PNE should be delivered as a stand-alone intervention. It therefore remains sensible to recommend that education be delivered in conjunction with other pain management approaches as we cannot confidently conclude that education alone is effective in reducing pain intensity or related disability in...
Source: Systematic Reviews - October 1, 2015 Category: Global & Universal Source Type: research

NatHER: protocol for systematic evaluation of trends in survival among patients with HER2-positive advanced breast cancer
This study will evaluate current and evolving trends in survival associated with HER2-positive advanced breast cancer over nearly 30 years and will build upon prior, less comprehensive, systematic analyses. This information is important to patients, healthcare providers, and researchers, particularly in the advanced disease setting, in which new therapies have been recently approved. Including observational studies allows us to evaluate real-world effectiveness; useful information will be gained by comparing findings from observational studies with those from ICTs. Systematic review re...
Source: Systematic Reviews - October 1, 2015 Category: Global & Universal Source Type: research

Interventions for preventing or treating malnutrition in problem drinkers who are homeless or vulnerably housed: protocol for a systematic review
Discussion The results of this review should help to inform the development of effective interventions that can be implemented in the community to improve the health of homeless people who are problem drinkers. Systematic review registration PROSPERO CRD42015024247 (Source: Systematic Reviews)
Source: Systematic Reviews - September 29, 2015 Category: Global & Universal Source Type: research

Physical rehabilitation interventions for adult patients with critical illness across the continuum of recovery: an overview of systematic reviews protocol
Discussion We anticipate the findings from this novel overview of systematic reviews will contribute to the synthesis and interpretation of existing evidence regarding physical rehabilitation interventions and physical recovery in post-critical illness patients across the continuum of recovery. Systematic review registration PROSPERO CRD42015001068. (Source: Systematic Reviews)
Source: Systematic Reviews - September 29, 2015 Category: Global & Universal Source Type: research

Protocol for a systematic review on the effect of demand generation interventions on uptake and use of modern contraceptives in LMIC
The objectives of the review will be as follows: (1) to synthesize evidence on the impacts and costs of family planning demand generation interventions and on their effectiveness in improving modern contraceptive use and (2) to identify the indicators used to assess effectiveness, cost-effectiveness, and impacts of demand generation interventions. Methods/design We will systematically review the public health and health promotion literature in several databases (e.g., CINAHL, Medline, EMBASE) as well as gray literature. We will select articles from 1970 to 2015, in French and in ...
Source: Systematic Reviews - September 28, 2015 Category: Global & Universal Source Type: research

Do evidence summaries increase policy-makers’ use of evidence from systematic reviews: A systematic review protocol
Discussion The results of this review will inform the development of future systematic review summaries to ensure that systematic review evidence is accessible to and used by policy-makers making health-related decisions. (Source: Systematic Reviews)
Source: Systematic Reviews - September 28, 2015 Category: Global & Universal Source Type: research

Effect of non-surgical, non-pharmacological weight loss interventions in patients who are obese prior to hip and knee arthroplasty surgery: a rapid review
Conclusions There is limited evidence to support the recommendation of weight loss in the year prior to TJA and to determine the effectiveness of short-term non-pharmacological, non-surgical weight management interventions on patient and surgical outcomes. (Source: Systematic Reviews)
Source: Systematic Reviews - September 27, 2015 Category: Global & Universal Source Type: research

Epidemiology of hepatitis A virus in Africa among persons aged 1–10 years: a systematic review protocol
Discussion The systematic review will generate up-to-date information on the current burden of hepatitis A virus in Africa. This information may have implications on policy for hepatitis A vaccination on individual African countries. Systematic review registration CRD42015023764 (Source: Systematic Reviews)
Source: Systematic Reviews - September 26, 2015 Category: Global & Universal Source Type: research

Rapid Review Summit: an overview and initiation of a research agenda
Abstract The demand for accelerated forms of evidence synthesis is on the rise, largely in response to requests by health care decision makers for expeditious assessment and up-to-date information about health care technologies and health services and programs. As a field, rapid review evidence synthesis is marked by a tension between the strategic priority to inform health care decision-making and the scientific imperative to produce robust, high-quality research that soundly supports health policy and practice. In early 2015, the Canadian Agency for Drugs and Technologies in Health convened a forum in...
Source: Systematic Reviews - September 26, 2015 Category: Global & Universal Source Type: research

Use of inhaled corticosteroids for the prevention and/or treatment of bronchopulmonary dysplasia in preterm infants: a systematic review protocol
Discussion Meta-analytic estimates of eligible RCTs, potentially including a new large RCT, may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm infants. Systematic review registration PROSPEROCRD42015019628 (Source: Systematic Reviews)
Source: Systematic Reviews - September 25, 2015 Category: Global & Universal Source Type: research

Interventions for preventing, delaying the onset, or decreasing the burden of frailty: an overview of systematic reviews
Discussion Following the completion of the synthesis, we will use the findings to develop an evidence brief that mobilizes the best available evidence about the problem related to preventing, delaying the onset, or decreasing the burden of frailty symptoms in older adults, policy and programmatic options to address the problem and implementation considerations. The evidence brief will then be used as the input into a stakeholder dialogue, which will engage 18–22 Canadian health-system leaders (including policymakers, health providers, researchers, and other stakeholders) in ‘off-the-record’ del...
Source: Systematic Reviews - September 25, 2015 Category: Global & Universal Source Type: research

Specialist palliative care services for adults with advanced, incurable illness in hospital, hospice, or community settings—protocol for a systematic review
Discussion The available evidence will be summarized and discussed to provide a basis for decision-making among health care professionals and policy makers. For SPC, we believe that multi-professional care is of utmost importance. Therefore, single-profession interventions such as physician consultations will not be included. Based on the multi-dimensional scope of palliative care, we chose QoL as the primary outcome, despite an expected heterogeneity among the QoL outcomes. We consider unidimensional endpoints such as “pain” for the physical domain to be inadequate for capturing the true scope of (S...
Source: Systematic Reviews - September 25, 2015 Category: Global & Universal Source Type: research

The effects of iodine blocking following nuclear accidents on thyroid cancer, hypothyroidism, and benign thyroid nodules: design of a systematic review
Discussion This proposed systematic review will update the existing WHO guideline from 1999. New evidence on the efficacy of KI administration to reduce thyroid cancer, hypothyroidism, and benign thyroid nodules in the event of an accidental release of radioactive iodine to the environment will provide the basis for an update of the WHO guideline for iodine prophylaxis following nuclear accidents. Systematic review registration PROSPERO CRD42015024340 (Source: Systematic Reviews)
Source: Systematic Reviews - September 24, 2015 Category: Global & Universal Source Type: research

Diagnostic accuracy of fine needle aspiration biopsy for detection of malignancy in pediatric thyroid nodules: protocol for a systematic review and meta-analysis
Discussion This meta-analysis will determine the diagnostic accuracy of FNAB for detection of malignancy in pediatric thyroid nodules and explore whether heterogeneity observed across studies may be explained by variations in patient population, FNAB technique or interpretation, and/or study-level risks of bias. This will be the first study to determine the accuracy of Bethesda cytological classification levels of FNAB (benign, atypical, follicular, suspicious, malignant). We expect that our results will help in guiding clinical decision-making in children with thyroid nodules. ...
Source: Systematic Reviews - September 24, 2015 Category: Global & Universal Source Type: research

The effectiveness and safety of treatments used for polycystic ovarian syndrome management in adolescents: a systematic review and network meta-analysis protocol
The objective of this study is to review and synthesize all the available evidence on treatment options for PCOS among adolescent women. Methods/design We will conduct a systematic review of all randomized controlled trials evaluating the use of metformin, oral contraceptive pills as monotherapy, or as combination with pioglitazone, spironolactone, flutamide, and lifestyle interventions in the treatment of PCOS in adolescent women ages 11 to 19 years. The primary outcome measures are menstrual regulation and change hirsutism scores. The secondary outcome measures include acn...
Source: Systematic Reviews - September 23, 2015 Category: Global & Universal Source Type: research

Community-onset sepsis and its public health burden: protocol of a systematic review
Discussion Timeliness and accuracy of diagnosis of sepsis are both crucial aspects for improving the patient’s outcome. The findings of this review will be discussed with a view to better inform future recommendations on improving public-facing campaigns, timely presentation, and diagnosis of sepsis in the community. The review will also discuss gaps in evidence and highlight future research and policy-making avenues for improving public health planning. Systematic review registration PROSPERO CRD42015023484 (Source: Systematic Reviews)
Source: Systematic Reviews - September 23, 2015 Category: Global & Universal Source Type: research

Cochrane systematic reviews and co-publication: dissemination of evidence on interventions for ophthalmic conditions
Conclusions The findings support encouraging co-publication while maintaining the primacy of the Cochrane systematic review. Support for co-publication may be tempered by other factors such as the possibility that CEVG reviews with a co-publication covered more clinically important and timely topics than those without a co-publication. Assuming that citations are a valid measure of dissemination effectiveness, the 15-year CEVG experience with co-publication of systematic reviews suggests that Cochrane authors should be encouraged to co-publish in traditional medical journals. (Source: Systematic Reviews)
Source: Systematic Reviews - September 22, 2015 Category: Global & Universal Source Type: research

Systematic review protocol of interventions to improve the psychological well-being of general practitioners
Discussion The systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidance. This will be the first systematic review on this topic, and the evidence synthesis will aid decision-making by general practitioners, policy makers and planners regarding ways in which to improve GP well-being. Findings will be disseminated at general practitioner meetings, conferences and in professional and peer-reviewed journals. Systematic review registration PROSPERO CRD42015017899 (Source: Systematic Reviews)
Source: Systematic Reviews - September 22, 2015 Category: Global & Universal Source Type: research

Comparison of physical interventions, behavioral interventions, natural health products, and pharmacologics to manage hot flashes in patients with breast or prostate cancer: protocol for a systematic review incorporating network meta-analyses
Discussion Our review will include a broad range of interventions that patients with breast and prostate cancer have attempted to use to manage hot flashes. Our work will establish the extent of evidence underlying these interventions and will employ an inclusive approach to analysis to inform comparisons between them. Our findings will be shared with Cancer Care Ontario for consideration in the development of guidance related to supportive care in these patients. Systematic review registration PROSPERO: CRD42015024286 (Source: Systematic Reviews)
Source: Systematic Reviews - August 27, 2015 Category: Global & Universal Source Type: research