Identifying models of delivery, care domains and quality indicators relevant to palliative day services: a scoping review protocol
DiscussionIdentifying, developing and implementing evidence-based quality indicators is critical to the evaluation and continued improvement of palliative care. Review findings will be used to support clinicians and policymakers make decisions on which quality indicators are most appropriate for evaluating day services at the patient and service level, and to identify areas for further research. (Source: Systematic Reviews)
Source: Systematic Reviews - May 16, 2017 Category: International Medicine & Public Health Source Type: research

An overview of systematic reviews of complementary and alternative therapies for fibromyalgia using both AMSTAR and ROBIS as quality assessment tools
ConclusionsOverall, five reviews scored 6 or above using the AMSTAR scale and the inter-rater agreement was good (83.6%), whereas seven reviews achieved a low risk of bias rating using ROBIS and the inter-rater agreement was fair (60.0%). No firm conclusions were drawn for efficacy of either spinal manipulation or homoeopathy for FM. There is limited evidence for topicalCapsicum, but further research is required. There is some evidence to support the effectiveness of acupuncture for FM, but further high-quality trials are needed to investigate its benefits, harms and mechanisms of action, compared with no or standard treat...
Source: Systematic Reviews - May 15, 2017 Category: International Medicine & Public Health Source Type: research

Paraquat and Parkinson ’s disease: a systematic review protocol according to the OHAT approach for hazard identification
DiscussionThis is the first time that the OHAT systematic review protocol will be applied to investigate a possible causal association between exposure to paraquat and PD. Results from this study could serve as basis for regulatory agencies to define paraquat levels of concern, supporting its risk assessment process.Systematic review registrationPROSPERO CRD42016050861 (Source: Systematic Reviews)
Source: Systematic Reviews - May 15, 2017 Category: International Medicine & Public Health Source Type: research

Cardioprotective potential of N -acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review
DiscussionAlthough several studies have shown that NAC can ameliorate hyperglycaemia-induced oxidative damage within the heart, this systematic review will be the first pre-registered synthesis of data to identify the cardioprotective potential of NAC against hyperglycaemia-induced oxidative damage. This result will help guide future research evaluating the cardioprotective role of NAC against DCM and better identify possible mechanisms of action for NAC to prevent oxidative damage with a diabetic heart.Systemic review registrationPROSPEROCRD42017055851. (Source: Systematic Reviews)
Source: Systematic Reviews - May 12, 2017 Category: International Medicine & Public Health Source Type: research

Behavioral interventions to promote adequate sleep among women: protocol for a systematic review and meta-analysis
DiscussionThis review will provide valuable information to those interested in promoting adequate sleep among women and, hopefully, encourage additional research in this important field to promote maternal, fetal, and infant health.Systematic review registrationThe study protocol was registered in PROSPERO in October 2016 (CRD42016049538). (Source: Systematic Reviews)
Source: Systematic Reviews - May 11, 2017 Category: International Medicine & Public Health Source Type: research

The effects of clinical supervision on supervisees and patients in cognitive-behavioral therapy: a study protocol for a systematic review
This study will include a systematic review of the literature to identify studies that have empirically investigated the effects of supervision on supervised psychotherapists and/or the supervisees ’ patients. A comprehensive search strategy will be conducted to identify published controlled studies indexed in the MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases. Data on supervision outcomes in both psychotherapists and their patients will be extracted, synthesized, and reported. Ri sk of bias and quality of the included studies will be assessed systematically.DiscussionThis systematic review will rigorously...
Source: Systematic Reviews - May 11, 2017 Category: International Medicine & Public Health Source Type: research

Protocol of a scoping review on knowledge translation competencies
DiscussionWe expect the identified KT competencies to contribute to the KT science by providing positive outcomes in practice, policy, education, and future research. Incorporation of the core KT competencies may enhance safety, effectiveness of clinical care, and quality of health outcomes; contribute to and facilitate collaboration among practitioners, knowledge users, knowledge brokers, researchers, employers, and educators; improve education of healthcare professionals and inform policy-making process; benefit practitioners by guiding their KT professional development to become effective at moving evidence into practic...
Source: Systematic Reviews - May 2, 2017 Category: Global & Universal Source Type: research

Perioperative adjuvant corticosteroids for post-operative analgesia in elective knee surgery – A systematic review
DiscussionThis systematic review of the perioperative adjunctive use of corticosteroids will assess the analgesic effects, post-operative nausea and vomiting, opiate consumption, infection rates and time till discharge and assess whether adjunctive corticosteroids should be encouraged in elective knee surgery.Systematic review registrationPROPSERO CRD42016049336 (Source: Systematic Reviews)
Source: Systematic Reviews - April 27, 2017 Category: Global & Universal Source Type: research

Prevention of cervical cancer in HIV-seropositive women from developing countries: a systematic review protocol
DiscussionThis review will address the gap in evidence by systematically reviewing the published literature on the different prevention modalities being used to prevent cervical cancer in HIV-seropositive women in developing countries. The findings may be used to inform evidence-based guidelines for prevention of cervical cancer in seropositive women as well as future research.Systematic review registrationPROSPEROCRD42017054678. (Source: Systematic Reviews)
Source: Systematic Reviews - April 24, 2017 Category: Global & Universal Source Type: research

MOrtality and infectious complications of therapeutic E ndo VA scular interventional radiology: a systematic and meta-analysis protocol
DiscussionThis systematic review will provide a synthesis of EIR complications. The spotlighted results will be analyzed in order to provide a state-of-knowledge synopsis of the current evidence base in relation to the epidemiology of the infectious complications after EIR. In the event of conclusive results, our findings will serve as a reference background to assess guidelines on reality of the problem of the infections linked to endovascular interventional radiology and to formulate of assumptions and propose preventive measures, based on the results of our investigations. These propositions will aim to reduce the risk ...
Source: Systematic Reviews - April 24, 2017 Category: Global & Universal Source Type: research

N of 1 trials and the optimal individualisation of drug treatments: a systematic review protocol
DiscussionThis review will provide new insights into the clinical utility of N of 1 drug trials in helping participants find the most acceptable treatment as defined by patients and clinicians based on the selected outcome measures and the perspectives of participants involved in such trials. Findings from this review will inform the development of a stakeholder workshop and guidance to help physicians find the optimum therapy for their patients and will help guide future research on N of 1 trials.Systematic review registrationPROSPEROCRD42016032452 (Source: Systematic Reviews)
Source: Systematic Reviews - April 24, 2017 Category: Global & Universal Source Type: research

Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data
AbstractBackgroundGaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course. Plasma chitotriosidase activity and CC chemokine ligand 18 (CCL18) have been exchangeably used for monitoring GD activity and response to enzyme replacement therapy in conjunction with clinical assessment. Yet, a large-scale head-to-head comparison of these two biomarkers is currently lacking. We propose a collaborative systematic review with meta-analysis of individual participant data (IPD) ...
Source: Systematic Reviews - April 20, 2017 Category: Global & Universal Source Type: research

Protocol: a systematic review of studies developing and/or evaluating search strategies to identify prognosis studies
DiscussionThis systematic review will identify all existing validated prognosis search filters and synthesise evidence about their applicability and performance. These findings will identify if current filters provide a proficient means of searching electronic bibliographic databases or if further prognosis filters are needed and can feasibly be developed for systematic searches of prognosis studies. (Source: Systematic Reviews)
Source: Systematic Reviews - April 20, 2017 Category: Global & Universal Source Type: research

Updated systematic review: associations between proximity to animal feeding operations and health of individuals in nearby communities
ConclusionsFew studies reported an association between surrogate clinical outcomes and AFO proximity for respiratory tract-related outcomes. There were no consistent dose-response relationships between surrogate clinical outcome and AFO proximity. A new finding was that Q fever in goats is likely associated with an increased Q fever risk in community members. The review results for the non-respiratory health outcomes were inconclusive because only a small number of studies were available or the between-study results were inconsistent.Systematic review registrationPROSPEROCRD42014010521 (Source: Systematic Reviews)
Source: Systematic Reviews - April 18, 2017 Category: Global & Universal Source Type: research

Which learning activities enhance physiotherapy practice? A systematic review protocol of quantitative and qualitative studies
AbstractBackgroundLearning activities are fundamental for the development of expertise in physiotherapy practice. Continuing professional development (CPD) encompasses formal and informal learning activities undertaken by physiotherapists. Identifying the most efficient and effective learning activities is essential to enable the profession to assimilate research findings and improve clinical skills to ensure the most efficacious care for clients. To date, systematic reviews on the effectiveness of CPD provide limited guidance on the most efficacious models of professional development for physiotherapists. The aim of this ...
Source: Systematic Reviews - April 17, 2017 Category: Global & Universal Source Type: research

Patient- and family-centered performance measures focused on actionable processes of care for persistent and chronic critical illness: protocol for a systematic review
AbstractBackgroundApproximately 5 to 10% of critically ill patients transition from acute critical illness to a state of persistent and in some cases chronic critical illness. These patients have unique and complex needs that require a change in the clinical management plan and overall goals of care to a focus on rehabilitation, symptom relief, discharge planning, and in some cases, end-of-life care. However, existing indicators and measures of care quality, and tools such as checklists, that foster implementation of best practices, may not be sufficiently inclusive in terms of actionable processes of care relevant to thes...
Source: Systematic Reviews - April 17, 2017 Category: Global & Universal Source Type: research

Effectiveness of current policing-related mental health interventions in England and Wales and Crisis Intervention Teams as a future potential model: a systematic review
The objectives of the review are firstly to identify and report research on the relevant interventions, nationally and internationally and then secondly to consider, when possible, which interventions or aspects of those interventions are effective. This is judged with regard to changes in mental health status or service use and future offending behaviour.The approaches to be considered have gained a good deal of support and funding over recent years, and this review will provide a systematic review of the underpinning research evidence to inform future commissioning, service design and investment decisions. (Source: Systematic Reviews)
Source: Systematic Reviews - April 17, 2017 Category: Global & Universal Source Type: research

The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysis  protocol
ConclusionsThis review will systematically and comprehensively review diagnostic and management practices associated with the Spitz nevus. This overview of current literature will hopefully provide the foundation for future standardization of clinical practice.Systematic review registrationPROSPEROCRD42016034045 (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2017 Category: Global & Universal Source Type: research

Early identification of patients requiring massive transfusion, embolization, or hemostatic surgery for traumatic hemorrhage: a systematic review protocol
DiscussionThis systematic review will describe the availability of multivariable prediction models and summarize evidence regarding predictors that can be used to identify the need for intervention in patients with traumatic hemorrhage.Systematic review registrationPROSPEROCRD42017054589 (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2017 Category: Global & Universal Source Type: research

Determining the gaps between Cochrane reviews and trials of effectiveness of interventions for acute respiratory infections: an audit
ConclusionsWe identified many RCT topics that have not been systematically reviewed. They need to be addressed in a separate process to establish their priority to clinicians. (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2017 Category: Global & Universal Source Type: research

Approaches to interpreting and choosing the best treatments in network meta-analyses
We present ranking approaches ’ merits and limitations and provide an example of how to apply the results of a NMA to clinical practice. (Source: Systematic Reviews)
Source: Systematic Reviews - April 12, 2017 Category: Global & Universal Source Type: research

What do register-based studies tell us about migrant mental health? A scoping review
ConclusionsThis review systematically charts the register-based studies on migrants ’ mental health for the first time. It shows the main topics and gaps in knowledge in this research domain, discusses the disadvantages of register-based studies, and suggests new directions for forthcoming studies. (Source: Systematic Reviews)
Source: Systematic Reviews - April 11, 2017 Category: Global & Universal Source Type: research

Therapeutic interventions for alcohol dependence in non-inpatient settings: a systematic review and network meta-analysis (protocol)
DiscussionThis network meta-analysis aims to appraise and summarize the total evidence of therapeutic interventions for alcohol-dependent patients that require support for detoxification and can be treated in the community. The evidence will determine which combination of interventions are most promising for current practice and further investigation.Systematic review registrationPROSPEROCRD42016049779 (Source: Systematic Reviews)
Source: Systematic Reviews - April 11, 2017 Category: Global & Universal Source Type: research

Protocol for a systematic review of the factors associated with binge drinking among adolescents and young adults
This study aims to identify and organise the factors associated with binge drinking among young people aged 15 to 24  years; and to provide a framework to further understand these factors in order to better target prevention strategies.Methods/designThis systematic review of the literature will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. The databases PubMed, Embase, PsycINFO and Social Care will be searched for articles published between 1 January 2006 and 31 December 2015. Our search focuses on studies examining the risk factors for binge drinking among you...
Source: Systematic Reviews - April 11, 2017 Category: Global & Universal Source Type: research

Management of scorpion envenoming: a systematic review and meta-analysis of controlled clinical trials
ConclusionsThe polyvalent antivenom againstCentruroides sp. in USA/Mexico and the monovalent antivenom againstM. tamulus in India are effective for rapid resolution of symptoms. Prazosin is useful as an add-on therapy forM. tamulus stings. (Source: Systematic Reviews)
Source: Systematic Reviews - April 8, 2017 Category: Global & Universal Source Type: research

Inter-pregnancy interval and pregnancy outcomes among women with delayed childbearing: protocol for a systematic review
AbstractBackgroundWomen in high resource nations are increasingly delaying childbearing until their thirties. Delayed childbearing poses challenges for the spacing of a woman ’s pregnancies. Inter-pregnancy intervals
Source: Systematic Reviews - April 8, 2017 Category: Global & Universal Source Type: research

Epidemiology and reporting characteristics of overviews of reviews of healthcare interventions published 2012 –2016: protocol for a systematic review
The objectives are to: (1) investigate the epidemiological, descriptive, and reporting characteristics of a random sample of 100 overviews published from 2012 to 2016 and (2) compare these recently published overviews (2012 –2016) to those published prior to 2012 (based on the prior descriptive analyses).MethodsMedline, EMBASE, and CDSR will be searched for overviews published 2012 –2016, using a validated search filter for overviews. Only overviews written in English will be included. All titles and abstracts will be screened by one review author; those deemed not relevant will be verified by a second person f...
Source: Systematic Reviews - April 7, 2017 Category: Global & Universal Source Type: research

Digoxin versus placebo, no intervention, or other medical interventions for atrial fibrillation and atrial flutter: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
DiscussionThe results of this systematic review have the potential to benefit millions of patients worldwide as well as healthcare economy.Systematic review registrationPROSPERO CRD42016052935 (Source: Systematic Reviews)
Source: Systematic Reviews - April 5, 2017 Category: Global & Universal Source Type: research

Consolidating emerging evidence surrounding HIVST and HIVSS: a rapid systematic mapping protocol
DiscussionThis innovative approach will allow rapid cataloguing, documenting and dissemination of new evidence and key findings as they emerge into the public domain.Systematic review registrationThis protocol has not been registered with PROSPERO as they do not register systematic maps. (Source: Systematic Reviews)
Source: Systematic Reviews - April 5, 2017 Category: Global & Universal Source Type: research

Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer.Methods/designWe will perform an umbrella review of systematic reviews and conduct updated meta-analyses of observational studies (cohort and case-control) investigating the association between central nervous system disorders and the risk of developing or dying from any cancer or specific types of cancer. Searches involving PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science will be used to identify systematic rev...
Source: Systematic Reviews - April 4, 2017 Category: Global & Universal Source Type: research

Receptive and expressive English language assessments used for young children: a scoping review protocol
DiscussionThis information will help these professionals identify and select appropriate assessment methods or tools that can be used to support development and/or identify areas of delay or difficulty and plan, implement, and monitor the progress of interventions supporting the development of receptive and expressive language skills in individuals with diverse language needs (e.g., typically developing children, children with language delays and disorders, children learning English as a second or additional language, Indigenous children who may be speaking dialects of English). Researchers plan to evaluate the effectivene...
Source: Systematic Reviews - April 4, 2017 Category: Global & Universal Source Type: research

Epidemiology of chronic obstructive pulmonary disease in the global HIV-infected population: a systematic review and meta-analysis protocol
DiscussionThis systematic review and meta-analysis will give an overview of the epidemiology of COPD in the global HIV population to inform policy-makers and to provide accurate data that can underpin effective interventions for optimizing their detection and management.Systematic review registrationPROSPEROCRD42016052639. (Source: Systematic Reviews)
Source: Systematic Reviews - March 29, 2017 Category: Global & Universal Source Type: research

Variables associated with unplanned general adult ICU admission in hospitalised patients: protocol for a systematic review
We describe the protocol for a systematic review of variables associated with ICU admission.Methods/designMEDLINE, EMBASE, CINAHL and the Cochrane Library, including Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials (CENTRAL) will be searched for studies that assess the association of routinely recorded variables associated with subsequent unplanned ICU admission. Only studies involving adult patients admitted to general ICUs will be included. We will extract data relating to the statistical association between ICU admission and predictor variables, the quality of the studies an...
Source: Systematic Reviews - March 28, 2017 Category: Global & Universal Source Type: research

The effectiveness of health care provider physical activity recommendations in cancer survivors: a systematic review and meta-analysis protocol
DiscussionBy summarizing the best available evidence for the effectiveness of health care provider physical activity recommendations for increasing participation in physical activity among cancer survivors, the results of this systematic review and meta-analysis will help determine if making physical activity recommendations effectively changes cancer survivors behaviour. It will also help to identify knowledge gaps and highlight areas in need of additional research. (Source: Systematic Reviews)
Source: Systematic Reviews - March 27, 2017 Category: Global & Universal Source Type: research

Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis
ConclusionsThe quality of the body of evidence is low. A meta-analysis of all extractable data leads to rejection of our null hypothesis, but analysis of a small sub-group of reliable evidence does not support that rejection. Reliable evidence is lacking in condition-specific meta-analyses, precluding relevant conclusions. Better designed and more rigorous RCTs are needed in order to develop an evidence base that can decisively provide reliable effect estimates of non-individualised homeopathic treatment. (Source: Systematic Reviews)
Source: Systematic Reviews - March 24, 2017 Category: Global & Universal Source Type: research

An evaluation of the comparative effectiveness of geriatrician-led comprehensive geriatric assessment for improving patient and healthcare system outcomes for older adults: a protocol for a systematic review and network meta-analysis
DiscussionAs the proportion of older adults grows worldwide, the demand for specialized geriatric services that help manage complex health needs of older adults with multimorbidity will increase in many countries. Results from this systematic review and NMA will enhance decision-making and the efficient allocation of scarce geriatric resources. Moreover, active involvement of KUs throughout the review process will ensure the results are relevant to different levels of decision-making.Systematic review registrationPROSPEROCRD42014014008 (Source: Systematic Reviews)
Source: Systematic Reviews - March 24, 2017 Category: Global & Universal Source Type: research

The risk associated with spinal manipulation: an overview of reviews
ConclusionsIt is currently not possible to provide an overall conclusion about the safety of SMT; however, the types of SAEs reported can indeed be significant, sustaining that some risk is present. High quality research and consistent reporting of AEs and SAEs are needed.Systematic review registrationPROSPEROCRD42015030068. (Source: Systematic Reviews)
Source: Systematic Reviews - March 24, 2017 Category: Global & Universal Source Type: research

Convergent and sequential synthesis designs: implications for conducting and reporting systematic reviews of qualitative and quantitative evidence
ConclusionsPerforming systematic reviews of qualitative and quantitative evidence is challenging because of the multiple synthesis options. The findings provide guidance on how to combine qualitative and quantitative evidence. Also, recommendations are made to improve the conducting and reporting of this type of review. (Source: Systematic Reviews)
Source: Systematic Reviews - March 23, 2017 Category: Global & Universal Source Type: research

Effectiveness of early interventions for parental sensitivity following preterm birth: a systematic review protocol
DiscussionTo our knowledge, this will be the first systematic review to examine the effect of early interventions that promote parental sensitivity of parents of preterm infants in the neonatal intensive care unit. The results of this review will guide development of best practice guidelines and recommendations for further research and will have implications for neonatal clinical practice.Systematic review registrationPROSPERO CRD42016047083 (Source: Systematic Reviews)
Source: Systematic Reviews - March 23, 2017 Category: Global & Universal Source Type: research

Economic evaluation of interventions delivered by primary care providers to improve neurodevelopment in children aged under 5  years: protocol for a scoping review
DiscussionThis review appears to be the first to be conducted in this area. The findings will be an important resource for future systematic reviews on interventions that have a cost component. This information will be valuable for policy makers and programmers who work in public health or primary care settings. (Source: Systematic Reviews)
Source: Systematic Reviews - March 21, 2017 Category: Global & Universal Source Type: research

Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism —protocol for a systematic review
DiscussionThis review will be the first systematic review of this nature. The evidence synthesised will be useful to general practitioners in their management of hypothyroidism. Findings will be disseminated at conferences and in professional and peer-reviewed journals.Systematic review registrationPROSPEROCRD42015027211 (Source: Systematic Reviews)
Source: Systematic Reviews - March 21, 2017 Category: Global & Universal Source Type: research

Impact of different dietary approaches on glycemic control and cardiovascular risk factors in patients with type 2 diabetes: a protocol for a systematic review and network meta-analysis
DiscussionThis systematic review will synthesize the available evidence on the comparative efficacy of different dietary approaches in the management of glycosylated hemoglobin (primary outcome), fasting glucose, and cardiovascular risk factors in type 2 diabetes mellitus patients. The results of the present network meta-analysis will influence evidence-based treatment decisions since it will be fundamental for based recommendations in the management of type 2 diabetes.Systematic review registrationPROSPERO42016047464 (Source: Systematic Reviews)
Source: Systematic Reviews - March 20, 2017 Category: Global & Universal Source Type: research

Risk factors for pressure injury development in critically ill patients in the intensive care unit: a systematic review protocol
The objectives of this review are to identify patient-centred clinical factors that may be associated with PI development in the adult intensive care environment and to determine the effect size of the relationship between identified factors and PI development in this unique population.Method/designThe review will follow the PRISMA reporting guidelines for systematic reviews. Electronic databases (Cochrane; PubMed/MEDLINE; CINAHL (EBSCOhost); Embase; Scopus; PsycINFO; Proquest; Networked Digital Library of Theses and Dissertations; Australian Digital Theses Program, Grey literature, Google scholar, and Clinical Trial Regis...
Source: Systematic Reviews - March 20, 2017 Category: Global & Universal Source Type: research

Five shared decision-making tools in 5  months: use of rapid reviews to develop decision boxes for seniors living with dementia and their caregivers
ConclusionsThis approach enabled the development of clinical tools more rapidly than with a traditional systematic review. Future studies should evaluate the applicability of this approach to other teams/tools. (Source: Systematic Reviews)
Source: Systematic Reviews - March 15, 2017 Category: Global & Universal Source Type: research

Relationship between family caregiver burden and physical frailty in older adults without dementia: a systematic review
ConclusionsOur review suggests that caregivers of frail older adults experience burden and that the degree of burden may differ from that of other caregiver populations. The limited evidence does not allow conclusions to be drawn or to inform clinical practice. Further research is needed, given the salience of physical frailty and burden.Systematic review registrationPROSPERO CRD42015019198 (Source: Systematic Reviews)
Source: Systematic Reviews - March 14, 2017 Category: Global & Universal Source Type: research

Outcomes of dysvascular partial foot amputation and how these compare to transtibial amputation: a systematic review for the development of shared decision-making resources
ConclusionsAside from mortality, there was limited evidence regarding outcomes of dysvascular PFA, particularly how outcomes differ between levels of PFA and TTA. Acknowledging that there is considerable uncertainty given the small body of literature on many topics where the risk of bias is high, the available evidence suggests that a large proportion of people with PFA experience delayed wound healing and ipsilateral reamputation. People with TTA have increased risk of mortality compared to those with PFA, which may reflect that those considered suitable candidates for TTA have more advanced systemic disease that also inc...
Source: Systematic Reviews - March 14, 2017 Category: Global & Universal Source Type: research

The association between adverse pregnancy outcomes and maternal human papillomavirus infection: a systematic review protocol
DiscussionComprehensive and high-quality evidence of a negative effect of HPV on pregnancy outcomes might be an additional motivation for HPV vaccination. Absence of such relationship could dispel anxiety and reassure HPV-infected pregnant women and clinicians. Findings of a poor level of confidence will allow identification of current knowledge gaps on HPV-pregnancy outcome relationship that need further research.Systematic review registrationPROSPEROCRD42016033425 (Source: Systematic Reviews)
Source: Systematic Reviews - March 11, 2017 Category: Global & Universal Source Type: research

Post-operative outcomes after cleft palate repair in syndromic and non-syndromic children: a systematic review protocol
DiscussionThe evidence behind the optimal surgical approach to cleft palate repair is minimal, with no gold standard technique identified to date for a certain type of cleft palate. It is essential to appreciate how the complication rates differ between each surgical technique and each time point of repair, in order to optimize the management of these patients. A more critical evaluation of the outcomes of different cleft palate repair methods may also provide insight into more effective surgical approaches for different types of cleft palates. (Source: Systematic Reviews)
Source: Systematic Reviews - March 9, 2017 Category: Global & Universal Source Type: research

The effects of dietary and lifestyle interventions among pregnant women who are overweight or obese on longer-term maternal and early childhood outcomes: protocol for an individual participant data (IPD) meta-analysis
DiscussionThe proposed IPDMA provides an opportunity to evaluate the effect of dietary and lifestyle interventions among pregnant women who are overweight or obese on later maternal and early childhood health outcomes, including risk of obesity. This knowledge is essential to effectively translate research findings into clinical practice and public health policy.Systematic review registrationThis IPD has been prospectively registered (PROSPERO), ID numberCRD42016047165. (Source: Systematic Reviews)
Source: Systematic Reviews - March 9, 2017 Category: Global & Universal Source Type: research

Linking families with pre-school children from healthcare services to community resources: a systematic review protocol
DiscussionIt is important to understand how health services can facilitate access to wider services for their patients to address the wider determinants of health. This may impact on the experience of health inequalities. This review focuses on how this can be achieved for families with pre-school children, and the evidence obtained will be useful for informing future guidance on this topic.Systematic review registrationPROSPEROCRD42016034066 (Source: Systematic Reviews)
Source: Systematic Reviews - March 8, 2017 Category: Global & Universal Source Type: research