Case report: a rapid review approach used by the UK National Screening Committee to inform recommendations on general population screening for vasa praevia
ConclusionsIn this case report, the use of a rapid review as part of the UK NSC ’s process enabled a pragmatic approach to assessing the overall volume, quality and direction of literature on key questions relating to the viability of a population screening programme for VP. Based on our assessments of this single evidence summary, systematic review quality appraisal tools ma y undervalue rapid reviews. The validity of the methods used in this case report, as well as the wider generalisability of our insights relating to rapid review practice, reporting and quality assessment, requires analysis of a larger sample of ...
Source: Systematic Reviews - December 28, 2019 Category: International Medicine & Public Health Source Type: research

Effectiveness of remineralising agents in prevention and treatment of orthodontically induced white spot lesions: a protocol for a systematic review incorporating network meta-analysis
The objective of this study will be to compare the effectiveness and safety of current remineralising agents used in the management of WSLs in patients treated with fixed orthodontic appliances in any orthodontic setting.MethodsLiterature searches will be conducted in several electronic databases (from inception onwards): MEDLINE (via Ovid), Scopus, Embase, the Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), among others. Grey literature will be identified through searching clinical trials registries. Randomised controlled trials that compared the effectiveness of different remineralisatio...
Source: Systematic Reviews - December 28, 2019 Category: International Medicine & Public Health Source Type: research

Magnetic resonance spectroscopy across chronic pain disorders: a systematic review protocol synthesising anatomical and metabolite findings in chronic pain patients
This study is registered with PROSPEROCRD42018112640. (Source: Systematic Reviews)
Source: Systematic Reviews - December 26, 2019 Category: International Medicine & Public Health Source Type: research

Rehabilitation approaches for children living with HIV in sub-Saharan Africa: a protocol for scoping review
DiscussionThe information from studies will be discussed in relation to the research questions using a critical narrative to explore the emergent themes. The quality of studies will be appraised using the mixed method appraisal tool. The scoping review will provide a baseline of evidence on rehabilitation interventions for children living with HIV in sub-Saharan Africa. The scoping review will inform healthcare providers, scholars and policy developers about the current use of rehabilitation interventions and what gaps need to be addressed with further research and intervention development.Systematic review registrationOSF...
Source: Systematic Reviews - December 22, 2019 Category: International Medicine & Public Health Source Type: research

A protocol for systematic review of Plantago major L. effectiveness in accelerating wound-healing in animal models
DiscussionResults of this systematic review will be presented in a narrative synthesis form. They will provide a summary and clear understanding of the relevant current questions and evidences directly related toP. major effective tissue repair and healing. Outcomes of this systematic review will contribute with important information that could benefit future research efforts and potential applicability in humans.Systematic review registrationPROSPERO CRD42019121962 (Source: Systematic Reviews)
Source: Systematic Reviews - December 22, 2019 Category: International Medicine & Public Health Source Type: research

Preferred Reporting Items for Overviews of Reviews (PRIOR): a protocol for development of a reporting guideline for overviews of reviews of healthcare interventions
DiscussionA systematically developed reporting guideline for overviews could help to improve the accuracy, completeness, and transparency of overviews. This, in turn, could help maximize the value and impact of overviews by allowing more efficient interpretation and use of their research findings. (Source: Systematic Reviews)
Source: Systematic Reviews - December 22, 2019 Category: International Medicine & Public Health Source Type: research

The Systematic Review Data Repository (SRDR): descriptive characteristics of publicly available data and opportunities for research
ConclusionsUntil we arrive at a future in which the systematic review and broader research communities are comfortable with the accuracy of automated data extraction, re-use of data extracted by humans has the potential to help reduce redundancy and costs. The 152 projects with publicly available data through SRDR, and the more than 15,000 studies therein, are freely available to researchers and the general public who might be working on similar reviews or updates of reviews or who want access to the data for decision-making, meta-research, or other purposes. (Source: Systematic Reviews)
Source: Systematic Reviews - December 19, 2019 Category: International Medicine & Public Health Source Type: research

Respiratory syncytial virus prophylaxis for prevention of recurrent childhood wheeze and asthma: a protocol for a systematic review
DiscussionThis review will aid in determining if the relationship between RSV and asthma development is a causal one, by showing the effect (if any) of RSV prophylaxis on subsequent recurrent wheeze/asthma. If this study shows RSV prophylaxis to have no effect on the outcome of recurrent wheeze/asthma, the question of causality remains. (Source: Systematic Reviews)
Source: Systematic Reviews - December 18, 2019 Category: International Medicine & Public Health Source Type: research

The scale of neurodegeneration in moderate-to-severe traumatic brain injury: a systematic review protocol
DiscussionUnderstanding the scale and timelines of neurodegeneration in moderate-to-severe TBI (as well as which brain areas are most vulnerable to chronic declines) can inform intervention research designed to offset such changes. This may help improve patient outcome following moderate-to-severe TBI and, in turn, reduce the burden of the injury.Systematic review registrationPROSPEROCRD42019117548 (Source: Systematic Reviews)
Source: Systematic Reviews - December 17, 2019 Category: International Medicine & Public Health Source Type: research

Etiologic workup in cases of cryptogenic stroke: protocol for a systematic review and comparison of international clinical practice guidelines
DiscussionTo our knowledge, this will be the first review to systematically compare recommendations of international CPGs on investigating the aetiology of ischaemic stroke. The findings will allow for a better understanding of international perspectives on the optimum level of investigations required following a stroke and thus contribute to achieving greater international consensus on best practice in this important and complex area.Systematic review registrationPROSPEROCRD42019127822. (Source: Systematic Reviews)
Source: Systematic Reviews - December 16, 2019 Category: International Medicine & Public Health Source Type: research

Adding exercise to usual care in patients with hypertension, type 2 diabetes mellitus and/or cardiovascular disease: a protocol for a systematic review with meta-analysis and trial sequential analysis
DiscussionThe present systematic review will have the potential to aid patients, clinicians and decision-makers recommending exercise and thereby, benefit patients with hypertension, type 2 diabetes mellitus and/or cardiovascular disease.Systematic review registrationPROSPEROCRD42019142313 (Source: Systematic Reviews)
Source: Systematic Reviews - December 16, 2019 Category: International Medicine & Public Health Source Type: research

The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol
DiscussionThe current use of PZA for TB is based on over 60 years of clinical trial data, but this has never been synthesised to guide rationale use in future regimens and clinical trials.Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO) CRD42019138735 (Source: Systematic Reviews)
Source: Systematic Reviews - December 16, 2019 Category: International Medicine & Public Health Source Type: research

Mapping evidence on access to healthcare information by women of reproductive age in low-and-middle-income countries: scoping review protocol
DiscussionsThe scoping review will focus on women of reproductive age in LMICs. We anticipate finding relevant literature on the interventions aimed at accessing health care services in LMICs. The study findings will help reveal research gaps to guide future research.Scoping review registrationNot registered with PROSPERO (not needed).Protocol and registrationThis scoping review was not registered. (Source: Systematic Reviews)
Source: Systematic Reviews - December 15, 2019 Category: International Medicine & Public Health Source Type: research

Lifestyle interventions to maternal weight loss after birth: a systematic review
ConclusionICT-based interventions can support postpartum women to achieve a healthy lifestyle and weight control. Future studies should focus on larger sample sizes, longer follow-up periods, and adherence to the interventions.Systematic review registrationPROSPERO CRD42018080731 (Source: Systematic Reviews)
Source: Systematic Reviews - December 15, 2019 Category: International Medicine & Public Health Source Type: research

Prevalence of lifetime substances use among students in Ethiopia: a systematic review and meta-analysis
ConclusionThis meta-analysis highlighted the extent of lifetime prevalence of any substance, khat, alcohol, and cigarettes smoking among students in Ethiopia. Significant percent of high school students have exposed to substances. Policy makers should devise and implement strictly binding regulation to curb widespread of substances around educational institution premises at national level. Priority should be given to intervention strategies that help delay first use of substance to prevent problems later in life. Besides,  the problem warrants regular national-level educational institutions based studies focusing on t...
Source: Systematic Reviews - December 13, 2019 Category: International Medicine & Public Health Source Type: research

Feasibility and acceptability of living systematic reviews: results from a mixed-methods evaluation
ConclusionsFindings to date support feasibility and acceptability of LSR production. There are challenges that need to be addressed for living systematic reviews to be sustainable and have maximum value. The findings from this study will be used in discussions with the Cochrane community, key decision makers and people more broadly concerned with LSRs to identify and develop priorities for scale-up. (Source: Systematic Reviews)
Source: Systematic Reviews - December 13, 2019 Category: International Medicine & Public Health Source Type: research

The effectiveness of psychological interventions for fatigue in cancer survivors: systematic review of randomised controlled trials
ConclusionsThis review showed some tentative support for psychological interventions for fatigue after cancer treatment. However, as the RCTs were heterogeneous in nature and the number of high-quality studies was limited, definitive conclusions are not yet possible. With the growing need for stage-specific research in cancer, this review sought to inform current practice and to summarise the existing evidence base of randomised controlled trials in the area.Systematic review registrationPROSPERO registration number: CRD42014015219. (Source: Systematic Reviews)
Source: Systematic Reviews - December 12, 2019 Category: International Medicine & Public Health Source Type: research

Recovery rate and determinants of severe acute malnutrition children treatment in Ethiopia: a systematic review and meta-analysis
ConclusionThe recovery rate among severe acute malnourished children on the therapeutic feeding unit in Ethiopia lied within the international minimum sphere. Hence, health care providers shall strengthen the management of severe acute malnutrition and management other co-morbidities like congestive heart failure.Systematic review registrationPROSPEROCRD42019119124 (Source: Systematic Reviews)
Source: Systematic Reviews - December 12, 2019 Category: International Medicine & Public Health Source Type: research

Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol
DiscussionThis systematic review will summarize preclinical studies investigating the therapeutic efficacy of both small and large extracellular vesicles derived by mesenchymal stromal cells. Extracellular vesicles represent a possibility to harness the benefits of mesenchymal stromal cells with added benefits of reduced manufacturing costs and an improved safety profile. Hence, there has been an exponential increase in interest for developing this cell-free therapy with hundreds of preclinical studies published to date. However, a vast amount of heterogeneity between groups relates to methods of extracellular vesicle isol...
Source: Systematic Reviews - December 11, 2019 Category: International Medicine & Public Health Source Type: research

The comparative efficacy and risk of harms of the intravenous and subcutaneous formulations of trastuzumab in patients with HER2-positive breast cancer: a rapid review
ConclusionResults of studies indicate similar efficacy between the two routes of administration. The higher rates of adverse events for SC administration were mainly attributable to injection site –related events. The clinical decision of whether to administer trastuzumab SC or IV requires the consideration of several factors and should be determined individually. (Source: Systematic Reviews)
Source: Systematic Reviews - December 10, 2019 Category: International Medicine & Public Health Source Type: research

Benefits and harms of medical cannabis: a scoping review of systematic reviews
ConclusionsResults from the included reviews were mixed, with most reporting an inability to draw conclusions due to inconsistent findings and a lack of rigorous evidence. Mild harms were frequently reported, and it is possible the harms of cannabis-based medicines may outweigh benefits.Systematic review registrationThe protocol for this scoping review was posted in the Open Access (https://ruor.uottawa.ca/handle/10393/37247). (Source: Systematic Reviews)
Source: Systematic Reviews - December 9, 2019 Category: International Medicine & Public Health Source Type: research

Psychometric properties of the Jefferson Scale of Empathy: a COSMIN systematic review protocol
DiscussionA narrative description of the findings will be presented along with summary tables. Recommendations for use of the JSE with various cohorts and circumstances will be offered which may inform future research in this field.Systematic review registrationPROSPERO CRD42018111412 (Source: Systematic Reviews)
Source: Systematic Reviews - December 9, 2019 Category: International Medicine & Public Health Source Type: research

Nurses ’ perspectives on human rights when coercion is used in psychiatry: a systematic review protocol of qualitative evidence
DiscussionThis review will provide a synthesis of how psychiatric and mental health nurses integrate human rights principles into their practice, as well as it will identify research gaps in this area. The results of this review will then provide qualitative evidence to better understand how nurses can contribute to the recognition, protection, and advocate for human rights in a psychiatric context.Systematic review registrationPROSPERO,CRD42019116862 (Source: Systematic Reviews)
Source: Systematic Reviews - December 8, 2019 Category: International Medicine & Public Health Source Type: research

The characteristics of effective technology-enabled dementia education for health and social care practitioners: protocol for a mixed studies systematic review
DiscussionThe evidence generated from a systematic review of the current evidence is intended to inform the design and implementation of technology-enabled dementia education programmes and to advance the current academic literature at a time of unprecedented demographic and technological transition.Trial registrationPROSPERO,CRD42018115378. (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Barriers to and facilitators for use of augmentative and alternative communication and voice restorative devices in the adult intensive care unit: a scoping review protocol
DiscussionTo our knowledge, this will be the first scoping review to map and synthesize reported barriers and facilitators to communication strategy utilization in the adult ICU using a theoretical framework. The results of this scoping review will help to identify trends and gaps in the current evidence-base and support recommendations for improving patient-centered practice, policy, and research related to successfully establishing ICU patient communication. (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Mapping evidence of socio-cultural factors in intimate partner violence among young women: a scoping review protocol
DiscussionUnderstanding socio-cultural factors influencing intimate partner violence among young women is critical. This will enable researchers to map existing literature, map research gaps and guide future research.Systematic review registrationPROSPERO (CRD42018116463) (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Differentiated models of service delivery for antiretroviral treatment of HIV in sub-Saharan Africa: a rapid review protocol
DiscussionThis review will provide an initial picture of the status quo for the implementation of DSD in sub-Saharan Africa and identify directions for research and implementation support in the future. This big-picture analysis will be useful for ministries of health, implementers, and donor agencies to inform decision-making on DSD scale-up.Systematic review registrationPROSPERO:CRD42019118230 (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Early warning system models and components in emergency and disaster: a systematic literature review protocol
This study attempts to comprehensively search the previous studies with terms and expressions includingdisaster,emergency model,early warning system, and their synonyms at MESH. To this end, English articles, which have been published from 1980 to 2019, will be assessed. Google Scholar, PubMed, Web of Science, and Scopus databases as well as relevant specialized websites will be searched. Studies will be evaluated by two individuals independently.DiscussionTo the best of our knowledge, no systematic review of models, structures, and components of the early warning system has been conducted so far. This study is the first a...
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Screening PubMed abstracts: is class imbalance always a challenge to machine learning?
ConclusionsResampling techniques slightly improved the performance of the investigated machine learning techniques. From a computational perspective, random undersampling 35:65 may be preferred. (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Associations between school-based peer networks and smoking according to socioeconomic status and tobacco control context: protocol for a mixed method systematic review
DiscussionThis protocol is for a mixed methods synthesis of both social network findings, to investigate social structures and qualitative studies, to elicit contextual information. The review will synthesise changes in the context of social influence on adolescent smoking over time and geographically. As context is increasingly recognised as a key source of complexity, this enhanced understanding will help to inform future interventions targeting smoking through social influence. This will help to enhance their relevance to context, subsequent effectiveness and targeting of inequalities.Systematic review registrationPROSP...
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Garden-based interventions and early childhood health: a protocol for an umbrella review
DiscussionThis umbrella review aims to summarize the role that garden-based interventions play in health promotion for young children. We will focus on a number of diverse child health outcomes in an effort to comprehensively synthesize the evidence to inform future garden-based interventions, research, and policy.Systematic review registrationPROSPEROCRD42019106848 (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Risk of postoperative pulmonary complications in adult surgical patients with metabolic syndrome: a systematic review and meta-analysis protocol
DiscussionThis review will be the first to report and summarise the risk for and incidence of PPC in adult patients with MetS undergoing surgery across a range of surgical specialities. The results have the potential to inform the development of evidenced-based interventions to improve the management of PPC in the surgical patient with MetS. Findings from this systematic review and meta-analysis will inform a subsequent Delphi study on priorities and responses to PPC in patients with MetS. We will also disseminate our results through publication in scientific peer-reviewed journals, conference presentations and promotion t...
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

The impact of environmental cadmium exposure on type 2 diabetes risk: a protocol for an overview of systematic reviews
DiscussionThis overview will assess current evidence from systematic reviews for the association between cadmium exposure and risk of T2DM and other metabolic morbidities. This overview may be helpful for policy-makers and healthcare teams aiming to mitigate T2DM risk in populations at risk of cadmium exposure.Systematic review registrationPROSPERO CRD42019125956 (Source: Systematic Reviews)
Source: Systematic Reviews - December 5, 2019 Category: International Medicine & Public Health Source Type: research

Effect of implementation interventions on nurses ’ behaviour in clinical practice: a systematic review, meta-analysis and meta-regression protocol
DiscussionThis review will inform knowledge users and researchers interested in designing, developing and evaluating implementation interventions to support nurses ’ behaviour change in clinical practice. Results will provide key insights regarding which causal processes—i.e. mechanisms of action—should be targeted by these interventions, and which constituent components—i.e. behaviour change techniques—should be included in these interventions to in crease their effectiveness.Systematic review registrationThe protocol has been registered at the International Prospective Register of Systematic...
Source: Systematic Reviews - December 4, 2019 Category: International Medicine & Public Health Source Type: research

Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis
DiscussionThis is the study protocol for a systematic review on the effects of different antibiotic regimens for neonatal sepsis. The results of this systematic review intent to adequately inform stakeholders or health care professionals in the field of neonatal sepsis, and to aid appropriate development of treatment guidelines.Systematic review registrationPROSPERO reference number:CRD42019134300. (Source: Systematic Reviews)
Source: Systematic Reviews - December 4, 2019 Category: International Medicine & Public Health Source Type: research

Effectiveness of physical activity promotion and exercise referral in primary care: protocol for a systematic review and meta-analysis of randomised controlled trials
DiscussionThis systematic review and meta-analyses will summarise the evidence for the effectiveness of physical activity promotion and referral as interventions for improving physical activity, as well as whether studies using objective measures of physical activity have similar effects to those studies using self-report measures. This knowledge has importance for primary care clinicians, patients and, given the focus of the recent NHS long-term plan on preventive medicine, those making policy decisions.Systematic review registrationThe protocol is registered with PROSPERO the international prospective register of systema...
Source: Systematic Reviews - December 4, 2019 Category: International Medicine & Public Health Source Type: research

Do wastewater treatment plants increase antibiotic resistant bacteria or genes in the environment? Protocol for a systematic review
DiscussionAntibiotic resistance in environmental samples around wastewater treatment plants may pose a risk of exposure to workers and nearby residents. Results from the systematic review outlined in this protocol will allow to estimate the extend of exposure, to inform policy making and help to design future studies. (Source: Systematic Reviews)
Source: Systematic Reviews - December 4, 2019 Category: International Medicine & Public Health Source Type: research

Networked information technologies and patient safety: a protocol for a realist synthesis
DiscussionThe findings of this realist synthesis will shed light on how and why an important class of systems, that span organisations in a health economy, will contribute to changes in patients ’ clinical risks. We anticipate that the findings will be generalizable, in two ways. First, a refined mid-range theory will contribute to our understanding of the underlying mechanisms that, for a range of information technologies, lead to changes in clinical practices and hence patients’ risks (or not). Second, many governments are funding and implementing cross-organisational IT networks. The findings can inform poli...
Source: Systematic Reviews - December 4, 2019 Category: International Medicine & Public Health Source Type: research

Reporting quality of Cochrane systematic reviews with Chinese herbal medicines
ConclusionAlthough the Cochrane SRs of CHM showed reporting compliance with PRISMA checklist, their reporting quality needs improvement, especially about full reporting of CHM interventions and of TCM-related rationales. Reporting guideline of “PRISMA extension for CHM interventions” should be developed thus to improve their quality. (Source: Systematic Reviews)
Source: Systematic Reviews - December 2, 2019 Category: International Medicine & Public Health Source Type: research

Weight loss interventions for Hispanic women in the USA: a protocol for a systematic review
DiscussionThe aim of this systematic review is to critically examine existing weight loss interventions for Hispanic women in the U.S. and provide quality evidence for the effectiveness of these interventions on weight loss. Further, this review seeks to identify characteristics of effective interventions and suggest future directions for research efforts targeting weight loss in this population. This review will inform the development of future weight loss interventions for this population.Systematic review registrationPROSPEROCRD42019119094 (Source: Systematic Reviews)
Source: Systematic Reviews - November 30, 2019 Category: International Medicine & Public Health Source Type: research

Recruitment and retention of fathers with young children in early childhood health intervention research: a systematic review and meta-analysis protocol
DiscussionFindings from this review will help inform future intervention research with fathers to optimally recruit and retain participants. Identifying key factors should enable health researchers and program managers design and adapt interventions to increase the likelihood of increasing father engagement in early childhood health interventions. Researchers will be able to use this review to inform future research that addresses current evidence gaps for the recruitment and retention of fathers. This review will make recommendations for addressing key target areas to improve recruitment and retention of fathers in early ...
Source: Systematic Reviews - November 30, 2019 Category: International Medicine & Public Health Source Type: research

Quality of life and well-being from the perspective of patients on opioid agonist maintenance treatment: study protocol for a systematic review of qualitative research and a scoping review of measures
ConclusionThe findings from the reviews will contribute to obtain a genuine understanding of the perspective from users on OAMT regarding their perception of well-being and quality of life and will likely lead to greater patient centeredness when assessing such variables, which in turn may contribute to a more patient-centered care. (Source: Systematic Reviews)
Source: Systematic Reviews - November 30, 2019 Category: International Medicine & Public Health Source Type: research

The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
DiscussionThis systematic review will assess the association of telomere length with substance use disorders aside from nicotine addiction.Systematic review registrationPROSPERO registration number CRD42019119785 (Source: Systematic Reviews)
Source: Systematic Reviews - November 30, 2019 Category: International Medicine & Public Health Source Type: research

Psychological intervention for universal prevention of antenatal and postnatal depression among pregnant women: protocol for a systematic review and meta-analysis
DiscussionThe findings of this systematic review and meta-analysis will have both clinical and political importance in the context of perinatal mental health. In addition, this study will promote future studies and clarify the direction of research on universal prevention of perinatal depression.Systematic review registrationPROSPEROCRD42019118041 (Source: Systematic Reviews)
Source: Systematic Reviews - November 30, 2019 Category: International Medicine & Public Health Source Type: research

Diabetes drugs for nonalcoholic fatty liver disease: a systematic review
ConclusionsConsistent with existing clinical practice guidelines, which recommend lifestyle intervention and treatment for comorbidities related to fatty liver disease as first-line treatment, trial evidence supports the efficacy of some diabetes drugs (especially pioglitazone) in patients with NAFLD or NASH, though weight gain with some diabetes drugs may warrant caution. Larger trials are needed to better characterize the efficacy and harms of diabetes pharmacotherapy in these patients. (Source: Systematic Reviews)
Source: Systematic Reviews - November 28, 2019 Category: International Medicine & Public Health Source Type: research

Strategies and effects of promising school-based interventions to promote active school transportation by bicycle among children and adolescents: protocol for a systematic review
DiscussionThe planned systematic review can provide information about how bicycling is considered in school-based interventions as an effective strategy to promote active commuting to school among students. In this regard, the conclusions drawn from the review will establish a basis for researchers to plan and implement a comprehensive cycling intervention in the school setting.Systematic review registrationPROSPEROCRD42019125192 (Source: Systematic Reviews)
Source: Systematic Reviews - November 28, 2019 Category: International Medicine & Public Health Source Type: research

Prevalence and factors associated with poor mental health among healthcare professionals in low- and lower-middle-income countries: a systematic review protocol
DiscussionIn assessing the prevalence of mental health issues among healthcare professionals in LLMIC and identifying factors associated with positive or poor mental health, the review aims to synthesize all possible available information for policy makers and health system managers on a potentially highly important but not yet much-discussed issue and to highlight gaps in currently available knowledge.Systematic review registrationInternational Prospective Register of Systematic Reviews PROSPERO (registration numberCRD42019140036) (Source: Systematic Reviews)
Source: Systematic Reviews - November 28, 2019 Category: International Medicine & Public Health Source Type: research

Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol
DiscussionRegarding the role of exosomes and their cargoes in the function of reproductive tract, the possible beneficial or adverse effects following exosomal administration from younger women to older women will be evaluated in the systematic review. As a result, exosome therapy could be suggested as a novel therapeutic agent if the favorable results are identified. (Source: Systematic Reviews)
Source: Systematic Reviews - November 27, 2019 Category: International Medicine & Public Health Source Type: research

Effectiveness of trauma centers verification: Protocol for a systematic review
The objective of the study described in this protocol is to systematically review evidence on the effectiveness of trauma center verification for improving clinical processes and patient outcomes in injury care.MethodsWe will perform a systematic review of studies evaluating the association between trauma center verification and hospital mortality (primary outcome), as well as morbidity, resource utilization, and processes of care (secondary outcomes). We will search CINAHL, EMBASE, HealthStar, MEDLINE, and ProQuest databases, as well as key injury organization websites for gray literature. We will assess the methodologica...
Source: Systematic Reviews - November 27, 2019 Category: International Medicine & Public Health Source Type: research

Instrument-based tests for quantifying aqueous humour protein levels in uveitis: a systematic review protocol
DiscussionThe assessment of inflammation in anterior chamber protein levels currently relies on crude and subjective clinical examination. The findings of this review will identify non-invasive technologies which show good correlation with actual protein concentration, which could be used in routine clinical practice for objective monitoring of AC inflammation.Systematic review registrationPROSPERO CRD42017084167. Study screening stage has just been completed. (Source: Systematic Reviews)
Source: Systematic Reviews - November 25, 2019 Category: International Medicine & Public Health Source Type: research