Is heavy eccentric calf training superior to wait-and-see, sham rehabilitation, traditional physiotherapy and other exercise interventions for pain and function in mid-portion Achilles tendinopathy?
DiscussionThis systematic review and meta-analysis will allow us to investigate if there are difference in pain and function when comparing wait-and-see, sham interventions, traditional physiotherapy and different exercise interventions to the traditional heavy eccentric calf training protocol for mid-portion Achilles tendon pain.Systematic review registrationPROSPERO registration numberCRD42018084493. (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2018 Category: International Medicine & Public Health Source Type: research

Prevalence of depression and anxiety among undergraduate university students in low- and middle-income countries: a systematic review protocol
DiscussionThe results from this systematic review will help in informing and guiding healthcare practitioners, planners, and policymakers on the burden of common mental disorders in university students in LMICs and of appropriate and feasible interventions aimed at reducing the burden of psychological morbidity among them. The results will also point to gaps in research and help set priorities for future enquiries.Systematic review registrationPROSPEROCRD42017064148 (Source: Systematic Reviews)
Source: Systematic Reviews - April 10, 2018 Category: International Medicine & Public Health Source Type: research

Facilitators and barriers to the delivery of school-based smoking prevention interventions for children and young people: a protocol for a systematic review of qualitative studies
DiscussionThis review will focus on qualitative studies that seek to examine the barriers and facilitators to the delivery of school-based smoking prevention programmes in order to inform the design of future theory-based interventions in schools to prevent children and young people from smoking.Systematic review registrationPROSPEROCRD42014015483 (Source: Systematic Reviews)
Source: Systematic Reviews - April 6, 2018 Category: International Medicine & Public Health Source Type: research

Evidence of the factors that influence the utilisation of Kangaroo Mother Care by parents with low-birth-weight infants in low- and middle-income countries (LMICs): a scoping review protocol
DiscussionWe expect to find studies on barriers, challenges and facilitating factors of KMC utilisation by parents with LBWIs in LMICs. The review outcomes will guide future research and practice and inform policy. The findings will be disseminated in print, electronic and conference presentations related to maternal child and neonatal health. (Source: Systematic Reviews)
Source: Systematic Reviews - April 5, 2018 Category: International Medicine & Public Health Source Type: research

The use of standardized management protocols for critically ill patients with non-traumatic subarachnoid hemorrhage: a protocol of a systematic review and meta-analysis
DiscussionWe anticipate a significant degree of clinical heterogeneity in our review, as protocols will likely vary in their content, implementation, and ICU setting. We will aim to summarize the current literature in this domain to understand if SMPs, as a low-cost process-targeted intervention, improve outcomes for critically ill patients with SAH. Our review will additionally inform future research endeavors to improve the processes of care for this patient population.Systematic review registrationCRD42017069173 (Source: Systematic Reviews)
Source: Systematic Reviews - April 2, 2018 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of methods and cost-effectiveness findings of economic evaluations of obesity prevention and/or treatment interventions in children and adolescents
DiscussionThe findings from this review, which will include primary studies, will provide evidence to assist health policy decision makers interpret economic evaluations in this field. In addition, we will identify gaps in the current literature to inform future-related research.Systematic review registrationProsperoCRD42017062236 (Source: Systematic Reviews)
Source: Systematic Reviews - April 2, 2018 Category: International Medicine & Public Health Source Type: research

Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
This study will report and summarize epidemiology data, as well as the economic burden of HF in neonates, infants, children, and adolescents of LMICs. Limitations will mainly arise from the heterogeneity in the diagnostic of HF.Systematic review registrationPROSPERO CRD42017070189. (Source: Systematic Reviews)
Source: Systematic Reviews - April 2, 2018 Category: International Medicine & Public Health Source Type: research

How do we define and measure sarcopenia? Protocol for a systematic review
DiscussionSarcopenia is receiving greater attention in geriatrics research in recent years. Therefore, it is important to investigate how this condition is defined in the literature and whether these definitions can interfere with the reported estimates devoting more efforts on the topic. The results of this study can help to determine the most used definitions of sarcopenia reported in the literature, its strengths and limitations, and open a discussion about a need for a more valid, easy, and suitable one.Systematic review registrationPROSPEROCRD42015020832 (Source: Systematic Reviews)
Source: Systematic Reviews - March 27, 2018 Category: International Medicine & Public Health Source Type: research

Life course factors associated with metabolically healthy obesity: a protocol for the systematic review of longitudinal studies
This study aims to systematically review longitudinal studies investigating the association between life course exposures and future MHO status.MethodsElectronic databases (MEDLINE, SCOPUS, and Web of Science) will be searched using a trialled search strategy. Studies will be included following a double-screening process according to inclusion criteria to assess eligibility. Studies eligible for inclusion will include those that have a longitudinal observational design where a life course exposure occurred or was measured at least 1  year before the outcome, investigate a human study population, are published in Engli...
Source: Systematic Reviews - March 27, 2018 Category: International Medicine & Public Health Source Type: research

Effects of oncological care pathways in primary and secondary care on patient, professional, and health systems outcomes: protocol for a systematic review and meta-analysis
DiscussionFollowing the protocol outlined in this article, we aim to identify, assess, and synthesize all available evidence in order to provide an evidence base on the effects of oncological care pathways as reported in the literature.Systematic review registrationPROSPEROCRD42017057592. (Source: Systematic Reviews)
Source: Systematic Reviews - March 27, 2018 Category: International Medicine & Public Health Source Type: research

Correction to: Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol
AbstractThe correct title of the article [1] should be “Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol”. (Source: Systematic Reviews)
Source: Systematic Reviews - March 19, 2018 Category: International Medicine & Public Health Source Type: research

Economic evaluation of HIV pre-exposure prophylaxis strategies: protocol for a methodological systematic review and quantitative synthesis
DiscussionFindings will guide future economic evaluation of PrEP strategies in terms of methodological and knowledge gaps, and will inform decisions on the efficient integration of PrEP into public health programs across epidemiologic and health system contexts.Systematic review registrationPROSPEROCRD42016038440. (Source: Systematic Reviews)
Source: Systematic Reviews - March 15, 2018 Category: International Medicine & Public Health Source Type: research

Global and gene-specific DNA methylation in adult type 2 diabetic individuals: a protocol for a systematic review
DiscussionThis systematic review will evaluate published literature, assessing the link between DNA methylation and T2DM. Our findings could help guide future research evaluating epigenetic changes in T2DM and direct future therapeutic interventions. (Source: Systematic Reviews)
Source: Systematic Reviews - March 15, 2018 Category: International Medicine & Public Health Source Type: research

Technology-assisted title and abstract screening for systematic reviews: a retrospective evaluation of the Abstrackr machine learning tool
ConclusionsAbstrackr ’s reliability and the workload savings varied by screening task. Workload savings came at the expense of potentially missing relevant records. How this might affect the results and conclusions of SRs needs to be evaluated. Studies evaluating Abstrackr as the second reviewer in a pair would be of interest to determine if concerns for reliability would diminish. Further evaluations of Abstrackr’s performance and usability will inform its refinement and practical utility. (Source: Systematic Reviews)
Source: Systematic Reviews - March 12, 2018 Category: International Medicine & Public Health Source Type: research

Evaluating optimal utilisation of technology in type 1 diabetes mellitus from a clinical and health economic perspective: protocol for a systematic review
DiscussionThis systematic review protocol utilises rigorous methodology and pre-determined eligibility criteria to provide a uniquely comprehensive search for a broad spectrum of clinical and economic outcomes in comparing multiple currently available technologies for managing type 1 diabetes. Evidence on which technologies may be most appropriate for particular patient groups will be examined as well as the economic justification for funding of different technologies.Systematic review registrationPROSPERO (CRD42017077221) (Source: Systematic Reviews)
Source: Systematic Reviews - March 12, 2018 Category: International Medicine & Public Health Source Type: research

Evaluating characteristics of PROSPERO records as predictors of eventual publication of non-Cochrane systematic reviews: a meta-epidemiological study protocol
The objective of this study is to explore which factors are associated with a higher probability that results derived from a non-Cochrane PROSPERO registration record for a systematic review will be finally reported as an original article in a scientific journal.Methods/designThe PROSPERO repository will be web scraped to automatically and iteratively obtain all completed non-Cochrane registration records stored from February 2011 to December 2017. Downloaded records will be screened, and those with less than 90% fulfilled or are duplicated (i.e., those sharing titles and reviewers) will be excluded. Manual and human-super...
Source: Systematic Reviews - March 9, 2018 Category: International Medicine & Public Health Source Type: research

Evaluating the effect of delayed activation of rapid response teams on patient outcomes: a systematic review protocol
The objective of this review is to evaluate the effect of delayed response by rapid response teams on hospital mortality (primary), cardiac arrest, and intensive care transfer rates (secondary).MethodsThis review will include randomized and non-randomized studies which examined the effect of delayed response times by rapid response teams on patient mortality, cardiac arrest, and intensive care unit admission rates. This review will include studies of adult patients who have experienced a rapid response team consultation. The search strategy will utilize a combination of keywords and MeSH terms. MEDLINE and Embase will be s...
Source: Systematic Reviews - March 9, 2018 Category: International Medicine & Public Health Source Type: research

Digital storytelling as a method in health research: a systematic review protocol
DiscussionIn collaboration with national and international experts in digital storytelling, we will synthesize key evidence about digital storytelling that is critical to the development of methodological and ethical expertise about arts-based research methods. We will also develop recommendations for incorporating digital storytelling in a meaningful and ethical manner into the research process.Systematic review registrationPROSPERO registry numberCRD42017068002. (Source: Systematic Reviews)
Source: Systematic Reviews - March 5, 2018 Category: International Medicine & Public Health Source Type: research

Barriers, supports, and effective interventions for uptake of human papillomavirus- and other vaccines within global and Canadian Indigenous peoples: a systematic review protocol
DiscussionTo our knowledge, this study will contribute the first systematic review of documented barriers, supports, and interventions for vaccination in general and for HPV vaccination. The results of this study are expected to inform future research, policies, programs, and community-driven initiatives to enhance acceptability and uptake of HPV vaccination among Indigenous peoples.Systematic review registrationPROSPERO Registration Number: CRD42017048844 (Source: Systematic Reviews)
Source: Systematic Reviews - March 2, 2018 Category: International Medicine & Public Health Source Type: research

An introduction to overviews of reviews: planning a relevant research question and objective for an overview
ConclusionsClear decisions relating to the research questions and objectives are a fundamental first step during the initial planning stages for an overview. Key stakeholders should be involved at the earliest opportunity to ensure that the planned overview is relevant and meaningful to the potential end users of the overview. Following best practice in common with other forms of systematic evidence synthesis, an overview protocol should be published, ensuring transparency and reducing opportunities for introduction of bias in the conduct of the overview. (Source: Systematic Reviews)
Source: Systematic Reviews - March 1, 2018 Category: International Medicine & Public Health Source Type: research

The effects of interventions targeting multiple health behaviors on smoking cessation outcomes: a rapid realist review protocol
DiscussionThis review will provide evidence-based research on the context and mechanisms that may drive the success or failure of interventions designed to support multiple health behavior change. This information will be used to guide curriculum and program development for a government funded project on improving smoking cessation by addressing multiple health behaviors in people in Canada.Systematic review registrationPROSPEROCRD42017064430 (Source: Systematic Reviews)
Source: Systematic Reviews - March 1, 2018 Category: International Medicine & Public Health Source Type: research

Mobility and increased risk of HIV acquisition in South Africa: a mixed-method systematic review protocol
DiscussionThe proposed mixed-method systematic review will employ a three-phase sequential approach [i.e., (i) identifying relevant studies through data extraction (validated by use of Distiller-SR data management software), (ii) qualitative synthesis, and (iii) quantitative synthesis including meta-analysis data]. Recurrent ideas and conclusions from syntheses will be compiled into key themes and further processed into categories and sub-themes constituting the primary and secondary outcomes of this study. Synthesis of main findings from different studies examining the subject issue here may uncover important research gap...
Source: Systematic Reviews - February 27, 2018 Category: International Medicine & Public Health Source Type: research

Physical activity for people with young-onset dementia and carers: protocol for a scoping review
DiscussionThis will be the first review to systematically explore and critically appraise the current state of the evidence regarding physical activity for people with young-onset dementia and carers. It is hoped that findings from this review will be used to inform the development of future physical activity interventions, to serve as a basis for consultation with key stakeholders and to identify appropriate outcome measures relevant to people with young-onset dementia and carers.Systematic review registrationAt present, scoping reviews are not eligible for registration on the international prospective register of systema...
Source: Systematic Reviews - February 27, 2018 Category: International Medicine & Public Health Source Type: research

Structured approaches to promote patient and family engagement in treatment in acute care hospital settings: protocol for a systematic scoping review
DiscussionThis review aims to identify and classify the specific behavior change techniques underpinning patient and family engagement interventions used in acute care hospital settings. By identifying the “active ingredients” in these interventions, our findings will be transferable to a wide range of acute care hospital contexts and populations. (Source: Systematic Reviews)
Source: Systematic Reviews - February 26, 2018 Category: International Medicine & Public Health Source Type: research

Strategies for successful trauma registry implementation in low- and middle-income countries —protocol for a systematic review
This study explores strategies for successful trauma registry implementation in LMICs.MethodsThe protocol was registered a priori (CRD42017058586). A peer-reviewed search strategy of multiple databases will be developed with a senior librarian. As per PRISMA guidelines, first screen of references based on abstract and title and subsequent full-text review will be conducted by two independent reviewers. Disagreements that cannot be resolved by discussion between reviewers shall be arbitrated by the principal investigator. Data extraction will be performed using a pre-defined data extraction sheet. Finally, bibliographies of...
Source: Systematic Reviews - February 21, 2018 Category: International Medicine & Public Health Source Type: research

Drug discontinuation before contrast procedures and the effect on acute kidney injury and other clinical outcomes: a systematic review protocol
DiscussionThis systematic review will provide a synthesis of current evidence on the discontinuation of drugs prior to contrast procedures and its effect on CI-AKI and other clinical outcomes. These findings will provide clinicians with guidelines and serve as a strong research base for future studies in this field.Systematic review registrationPROSPEROCRD42016033178 (Source: Systematic Reviews)
Source: Systematic Reviews - February 21, 2018 Category: International Medicine & Public Health Source Type: research

Effectiveness of interventions aimed at improving physical and psychological outcomes of fall-related injuries in people with dementia: a narrative systematic review
ConclusionsDue to high heterogeneity across the studies, definitive conclusions could not be reached. Most post-fall interventions were not aimed at patients with dementia and have shown little efficacy regardless of cognitive status. Minor improvements to some quality of life indicators were shown, but these were generally not statistically significant. Conclusions were also limited due to most studies addressing hip fracture; the interventions provided for this type of injury may not be suitable for other types of fractures or soft tissue injuries, or for use in primary care.Systematic review registrationPROSPEROCRD42016...
Source: Systematic Reviews - February 20, 2018 Category: International Medicine & Public Health Source Type: research

Registration of systematic reviews in PROSPERO: 30,000 records and counting
ConclusionsRegistration of SRs in PROSPERO increased rapidly between 2011 and 2017, thus benefiting users of health evidence who want to know about ongoing SRs. Further work is needed to explore how closely published SRs adhere to the planned methods, whether greater pre-specification of outcomes prevents selective inclusion and reporting of study results, and whether registered SRs address necessary questions. (Source: Systematic Reviews)
Source: Systematic Reviews - February 20, 2018 Category: International Medicine & Public Health Source Type: research

A protocol for a systematic review of non-randomised evaluations of strategies to increase participant retention to randomised controlled trials
DiscussionThis review aims to gather and evaluate evidence on the effect of retention strategies examined in non-randomised studies. It is imperative to collect evidence from obseravational studies to infer whether or not these studies could be considered a practical way to complement or even replace a broadly favourable randomised design. If we find that non-randomised studies to be included in this review are of high quality with adequate control of biases, we will recommend to trialists and others not to rely exclusively on randomised studies and to give meticulous attention to the plentiful evidence that can be obtaine...
Source: Systematic Reviews - February 20, 2018 Category: International Medicine & Public Health Source Type: research

Cholera diagnosis in human stool and detection in water: protocol for a systematic review of available technologies
DiscussionThe systematic review builds on a previous scoping review in this field and expands upon this by synthesising data on both product technical characteristics and design features. The review will be of particular value to stakeholders engaged in diagnostic procurement and manufacturers interested in developing cholera or diarrheal disease diagnostics.Systematic review registrationPROSPEROCRD42016048428. (Source: Systematic Reviews)
Source: Systematic Reviews - February 20, 2018 Category: International Medicine & Public Health Source Type: research

Information needs in people with diabetes mellitus: a systematic review
ConclusionInformation needs in people with diabetes mellitus, appear to be high, yet poorly investigated. Research is needed regarding differences between diverse diabetes populations, including gender aspects or changes in information needs during the disease course.Systematic review registrationThe review protocol has been registered at Prospero (CRD42015029610). (Source: Systematic Reviews)
Source: Systematic Reviews - February 14, 2018 Category: International Medicine & Public Health Source Type: research

Pharmacotherapies for fatigue in chronic liver disease (CLD): a systematic review and meta-analysis (protocol)
DiscussionThis systematic review will examine the effectiveness of pharmacological therapies on fatigue reduction in people with CLD. Such therapies may be more effective than non-pharmacological interventions in treating fatigue symptoms in CLD. Evidence derived from the findings of this study will guide future practice, policy, and research.Systematic review registrationPROSPERO,CRD42017076957 (Source: Systematic Reviews)
Source: Systematic Reviews - February 14, 2018 Category: International Medicine & Public Health Source Type: research

Strategies for improving the lives of US women aged 40 and above living with HIV/AIDS: an evidence map
ConclusionThe evidence base that is directly applicable to women over 40 who live with HIV/AIDS in the USA is limited, and the research need is broad. We propose research prioritization strategies for this population. (Source: Systematic Reviews)
Source: Systematic Reviews - February 2, 2018 Category: International Medicine & Public Health Source Type: research

What is the impact on health and wellbeing of interventions that foster respect and social inclusion in community-residing older adults? A systematic review of quantitative and qualitative studies
ConclusionsWhilst this review suggests that some interventions may positively impact on the health outcomes of older people, and identified mediating factors to health outcomes, the evidence is based on studies with heterogeneous methodologies. Many of the interventions were delivered as projects to selected groups, raising important questions about the feasibility of wider implementation and the potential for population-wide benefits.Systematic review registrationPROSPERO registration numberCRD42014010107 (Source: Systematic Reviews)
Source: Systematic Reviews - January 30, 2018 Category: International Medicine & Public Health Source Type: research

Effects of dance on cognitive function among older adults: a protocol for systematic review and meta-analysis
The objective of this review is to summarize the effects of dance versus any other control group on cognitive function, physical function, adverse events, and quality of life in older adults.MethodWe will search the following databases MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) to identify the randomized controlled trials (RCTs) evaluating the effects of dance on cognitive function among older adults. Also, we will searchhttp://apps.who.int/trialsearch,clinicaltrials.gov and conference abstracts to identify ongoing and unpublished studies. There will be no restrictions on language, date, ...
Source: Systematic Reviews - January 27, 2018 Category: International Medicine & Public Health Source Type: research

Safety and efficacy of hematopoietic and mesanchymal stem cell therapy for treatment of T1DM: a systematic review and meta-analysis protocol
AbstractIntroductionInsulin standard treatment of T1DM cannot cure the patients as different chronic complications occurred subsequently. Investigations on a curative treatment in T1DM propose cell replacement or maintenance instead of exogenous insulin therapy, but different dimensions of this novel treatment are not clarified.Methods and analysisWe will include all clinical trials which have evaluated the efficacy MSC or HSC transplantation in T1DM treatment; electronically search bibliographic databases, country registration data banks, and gray literatures; and hand-search two key journals, two experts ’ article,...
Source: Systematic Reviews - January 26, 2018 Category: International Medicine & Public Health Source Type: research

Children ’s, parents’ and other stakeholders’ perspectives on early dietary self-management to delay disease progression of chronic disease in children: a protocol for a mixed studies systematic review with a narrative synthesis
DiscussionThis mixed studies systematic review with a narrative synthesis seeks to elucidate the gaps in current knowledge and generate a fresh explanation of research findings on early dietary self-management in chronic disease, with particular application to CKD, from the stakeholders ’ perspective. The review will provide an important platform to inform future research, identifying the facilitators and barriers to implementing early dietary interventions. Ultimately, the review will contribute vital information to inform future improvements in chronic disease. The lead author has a particular interest in CKD paedi...
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

The impact of financial incentives on physical activity in adults: a systematic review protocol
DiscussionThis systematic review will determine the effectiveness of positive and negative financial incentives on physical activity in adults. Findings will help inform the development of public health interventions and research in this field.Systematic review registrationPROSPERO 2017:CRD42017068263 (Source: Systematic Reviews)
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

Treatment of cervical cancer in HIV-seropositive women from developing countries: a protocol for a systematic review
DiscussionThe review findings will provide the current picture of the existing treatment methods being used to treat cervical cancer in HIV-seropositive women in developing countries. The findings might be used for the establishment of evidence-based guidelines for treatment of cervical cancer in seropositive women as well as prompt policy-makers and governments to decide and support future research in a way to find a lasting solution.Systematic review registrationPROSPERO CRD42017054676https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=54676 (Source: Systematic Reviews)
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

A comparison of meta-analytic methods for synthesizing evidence from explanatory and pragmatic trials
ConclusionsIn addition to the original intent of PRECIS-2 tool of aiding researchers in their choice of trial design, PRECIS-2 tool is useful for explaining between study variations in systematic review and meta-analysis of published trials. We recommend that researchers adopt mixture meta-regression methods when synthesizing evidence from explanatory and pragmatic trials. (Source: Systematic Reviews)
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

Global avian influenza outbreaks 2010 –2016: a systematic review of their distribution, avian species and virus subtype
ConclusionsAvian influenza virus has been proved to be able to contaminate all types of avian species, including commercial poultry farms, wild birds, backyard domestic animals, live poultry, game birds and mixed poultry. The study focused on wet markets, slaughterhouses, wild habitats, zoos and natural parks, in both developed and developing countries. The impact of avian influenza virus seems disproportionate and could potentially burden the already existing disparities in the public health domain. Therefore, a collaboration between all the involved health sectors is considered to be more than necessary. (Source: Systematic Reviews)
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

Treatment outcomes in patients with opioid use disorder initiated by prescription: a systematic review protocol
DiscussionWe expect that this review will help determine whether patients that were initially exposed to opioids through a prescription differ in OST treatment outcomes in comparison to people who used opioids through illicit means. We hope that this review will provide evidence related to prescription opioids exposure and future treatment outcomes, which will aid clinicians in their decisions to prescribe opioids or not for specific populations at risk.Systematic review registrationPROSPEROCRD42017058143 (Source: Systematic Reviews)
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

Response to ‘Increasing value and reducing waste in data extraction for systematic reviews: tracking data in data extraction forms’
AbstractᅟThis is a response to a Letter. Data abstraction is a time-consuming and error-prone systematic review task. Shokraneh and Adams categorize available techniques for tracking data during data abstraction into three methods: simple annotation, descriptive addressing, and Cartesian coordinate system. While we agree with the categorization of the techniques, we disagree with the authors ’ statement that descriptive addressing is a PDF-independent method, i.e., any sort of descriptive addressing must reference a specific version of PDF file and not just any PDF of said report. Different versions of PDFs of the ...
Source: Systematic Reviews - January 25, 2018 Category: International Medicine & Public Health Source Type: research

Applying the ROBINS-I tool to natural experiments: an example from public health
ConclusionThe ROBINS-I tool is a conceptually rigorous tool which focusses on risk of bias due to the counterfactual. Difficulties in applying ROBINS-I may be due to poor design and reporting of evaluations of natural experiments. While the quality of reporting may improve in the future, improved guidance on applying ROBINS-I is needed to enable existing evidence from natural experiments to be assessed appropriately and consistently. We hope future refinements to ROBINS-I will address some of the issues raised here to allow wider use of the tool. (Source: Systematic Reviews)
Source: Systematic Reviews - January 24, 2018 Category: International Medicine & Public Health Source Type: research

Anxiety and the development and maintenance of anorexia nervosa: protocol for a systematic review
DiscussionAlthough there are limitations to the present review, understanding the current evidence for the role of non-eating/weight-gain-related anxiety in AN can direct future research that may ensure accurate aetiological models of AN and effective treatments.Systematic review registrationThe study is registered on PROSPERO under the reference numberCRD42017069644 (Source: Systematic Reviews)
Source: Systematic Reviews - January 24, 2018 Category: International Medicine & Public Health Source Type: research

What are the barriers and facilitators for third sector organisations (non-profits) to evaluate their services? A systematic review
ConclusionsThis review constitutes the first systematic effort to synthesise existing literature on factors supporting and preventing evaluation by TSOs. The prevalence of factors revolving around the lack of support, resources and clarity on appropriate outcome indicators suggests that many of the identified challenges may be met by applying evidence-based and stakeholder-inclusive strategies to develop shared evaluation requirements. Future efforts should address the application of EBP as part of the commissioning process of TSOs. (Source: Systematic Reviews)
Source: Systematic Reviews - January 22, 2018 Category: International Medicine & Public Health Source Type: research

Physical activity and the prevention, reduction, and treatment of alcohol and/or substance use across the lifespan (The PHASE review): protocol for a systematic review
The objectives of this mixed methods systematic review are to describe and evaluate the quantitative and qualitative research obtained by a diverse search strategy on the impact of physical activity and its potential to:Reduce the risk of progression to alcohol and/or substance use (PREVENTION)Support individuals to reduce alcohol and/or substance use for harm reduction (REDUCTION), andPromote abstinence and relapse prevention during and after treatment for an alcohol and/or substance use disorder (TREATMENT).With the input of key stakeholders, we aim to assess how what we know can be translated into policy and practice. Q...
Source: Systematic Reviews - January 22, 2018 Category: International Medicine & Public Health Source Type: research

Psychotropic medication non-adherence and associated factors among adult patients with major psychiatric disorders: a protocol for a systematic review
DiscussionPsychiatric disorders remain a public health, social and economic concern worldwide. Management of major psychiatric disorders is highly affected by medication non-adherence. Thus, undertaking an integrated and multifaceted approach is necessary to reduce the burden of medication non-adherence, and enhance the quality of patients ’ life. Evidence is required to design appropriate intervention to prevent psychotropic medication non-adherence.Protocol registrationPROSPERO: 2017:CRD42017067436. (Source: Systematic Reviews)
Source: Systematic Reviews - January 22, 2018 Category: International Medicine & Public Health Source Type: research

Addition of platinum derivatives to neoadjuvant single-agent fluoropyrimidine chemoradiotherapy in patients with stage II/III rectal cancer: protocol for a systematic review and meta-analysis (PROSPERO CRD42017073064)
DiscussionThe findings of this systematic review and meta-analysis will provide novel insights into the efficacy and safety of combined neoadjuvant chemoradiotherapy including a platinum derivative and may form a basis for future clinical decision-making, guideline evaluation, and research prioritization.Systematic review registrationPROSPEROCRD42017073064 (Source: Systematic Reviews)
Source: Systematic Reviews - January 22, 2018 Category: International Medicine & Public Health Source Type: research

Intra-amniotic inflammation and child neurodevelopment: a systematic review protocol
DiscussionThis systematic review will report the current evidence regarding the association between amniotic inflammation and child neurodevelopment, and the modifiers of this association. The review will generate new hypotheses on pathological pathways and will guide future research.Systematic review registrationPROSPERO 2017 65065 (Source: Systematic Reviews)
Source: Systematic Reviews - January 22, 2018 Category: International Medicine & Public Health Source Type: research