User survey finds rapid evidence reviews increased uptake of evidence by Veterans Health Administration leadership to inform fast-paced health-system decision-making
ConclusionsVA ESP rapid reviews have increased the VHA ’s uptake of evidence to inform time-sensitive system-level decision-making. Key areas of interest for future evaluation include assessing user perception of our streamlined methods and the quality of our efforts to inform users of these methods, as well as comparing the usability and impact of ou r rapid and standard systematic reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - August 5, 2016 Category: Global & Universal Source Type: research

Checklist to operationalize measurement characteristics of patient-reported outcome measures
ConclusionsWe present a simplified checklist that can help guide systematic reviewers, researchers, and clinicians with varied measurement theory expertise to evaluate the strengths and weakness of candidate PRO measures ’ developmental properties and the appropriateness for specific applications. (Source: Systematic Reviews)
Source: Systematic Reviews - August 2, 2016 Category: Global & Universal Source Type: research

The effect of door-to-balloon delay in primary percutaneous coronary intervention on clinical outcomes of STEMI: a systematic review and meta-analysis protocol
This study aims to synthesize available evidence in order to answer the following questions: (1) what is the overall effect of D2B delay on clinical outcomes in patients with STEMI treated with primary PCI? (2) What factors explain the differences of the effect estimates among the studies? (3) What are the important strength and limitation of the existing body of evidence?MethodWe will search PubMed/MEDLINE, EMBASE, ClinicalTrials.gov, WHO International Clinical Trials Registry, CINAHL Database, and the Cochrane Library using a predefined search strategy. Other sources of literature will include proceedings from the Europe...
Source: Systematic Reviews - August 2, 2016 Category: Global & Universal Source Type: research

A protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials
DiscussionThis review aims to summarise the evidence on methods used to improve recruitment to randomised controlled trials. Carrying out a systematic review including only data from non-randomised studies is a novel approach, and one which some may argue is futile. However, we believe that the systematic evaluation of what is likely to be a substantial amount of research activity is necessary, worthwhile, and will yield valuable results for the clinical trials community regardless of whether the outcomes find in favour of one or more interventions.Should the results of this review suggest that non-randomised evaluations d...
Source: Systematic Reviews - August 2, 2016 Category: Global & Universal Source Type: research

Impact of cytomegalovirus reactivation on clinical outcomes in immunocompetent critically ill patients: protocol for a systematic review and meta-analysis
Discussion This systematic review aims to explore the impact of CMV reactivation on patient-centered outcomes and health resource utilization in immunocompetent critically ill patients. Our results will help to better define the burden of disease associated with CMV reactivation. Indeed, evidence to date suggests increased mortality in this patient population. However, the relationship between CMV reactivation and health resource utilization remains less clear. Based on our results, future study on the impact of CMV treatment or prophylaxis on outcomes (including those other than mortality) may be warranted. Systematic ...
Source: Systematic Reviews - July 28, 2016 Category: Global & Universal Source Type: research

An evidence map of the effect of Tai Chi on health outcomes
Conclusions Tai Chi has been applied in diverse clinical areas, and for a number of these, systematic reviews have indicated promising results. The evidence map provides a visual overview of Tai Chi research volume and content. Systematic review registration PROSPERO CRD42014009907 (Source: Systematic Reviews)
Source: Systematic Reviews - July 27, 2016 Category: Global & Universal Source Type: research

A systematic review protocol investigating tests for physical or physiological qualities and game-specific skills commonly used in rugby and related sports and their psychometric properties
Discussion Choosing an appropriate test to be included in the screening test battery should be based on sound psychometric properties of the test available. This systematic review will provide an overview of the tests commonly used in rugby union and other related high intermittent team sports characterised by skill executions using the hands and legs such as Rugby League and Australian Rules Football. In addition, the review will highlight the psychometric properties of the identified tests. This information is crucial in developing a sport-specific test battery which can be used for talent identification, especially amo...
Source: Systematic Reviews - July 27, 2016 Category: Global & Universal Source Type: research

The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours: protocol for a systematic review
Discussion The evidence base for the use of PBT in children with CNS tumours is likely to be relatively sparse, highly heterogeneous and potentially of a low quality with small sample sizes. Furthermore, selection and publication biases may limit the internal and external validity of studies. However, any tentative results from the review on potential treatment effects can be used to plan better quality research studies that are of a design appropriate for outcome comparison with conventional therapy. Systematic review registration PROSPERO CRD42015029583 (Source: Systematic Reviews)
Source: Systematic Reviews - July 27, 2016 Category: Global & Universal Source Type: research

Food groups and risk of chronic disease: a protocol for a systematic review and network meta-analysis of cohort studies
Discussion This is a presentation of the study protocol only. Results and conclusions are pending completion of this study. Our systematic review will be of great value to national and international authorities for evidence-based nutritional recommendation/guidelines, regarding the implementation of food-based dietary guidelines for prevention of chronic diseases. Moreover, our results can be implemented to develop new diet quality indices/scores. Systematic review registration PROSPERO CRD42016037069 (Source: Systematic Reviews)
Source: Systematic Reviews - July 27, 2016 Category: Global & Universal Source Type: research

The effectiveness of mental health courts in reducing recidivism and police contact: a systematic review protocol
Discussion By synthesizing the results of the studies, this systematic review will help illuminate gaps in the literature, direct future research, and inform policy makers. Systematic review registration PROSPERO CRD42016036084 (Source: Systematic Reviews)
Source: Systematic Reviews - July 27, 2016 Category: Global & Universal Source Type: research

Progesterone vs. synthetic progestins and the risk of breast cancer: a systematic review and meta-analysis
Conclusions Observational studies suggest that in menopausal women, estrogen and progesterone use may be associated with lower breast cancer risk compared to synthetic progestin. (Source: Systematic Reviews)
Source: Systematic Reviews - July 26, 2016 Category: Global & Universal Source Type: research

What change in body mass index is needed to improve metabolic health status in childhood obesity: protocol for a systematic review
Discussion This will be the first systematic review of studies to establish the change in BMI required to improve metabolic health status in obese children and adolescents. Systematic review registration PROSPERO CRD42016025317 (Source: Systematic Reviews)
Source: Systematic Reviews - July 26, 2016 Category: Global & Universal Source Type: research

Understanding the theoretical underpinning of the exercise component in a fall prevention programme for older adults with mild dementia: a realist review protocol
The objectives of this realist review are (i) to identify the underlying programme theory of strength and balance exercise interventions targeted at those individuals that have been identified as falling and who have a mild dementia and (ii) to explore how and why that intervention reduces falls in that population, particularly in the context of a community setting. This protocol will explain the rationale for using a realist review approach and outline the method. Methods A realist review is a methodology that extends the scope of a traditional narrative or systematic evidence r...
Source: Systematic Reviews - July 19, 2016 Category: Global & Universal Source Type: research

Risk factors for unplanned and crash dialysis starts: a protocol for a systematic review and meta-analysis
Discussion The results of this review will inform the design of strategies to help reduce the incidence of crash and unplanned dialysis starts. Systematic review registration Prospero CRD42016032916 (Source: Systematic Reviews)
Source: Systematic Reviews - July 19, 2016 Category: Global & Universal Source Type: research

The impact of intervention strategies that target arterial stiffness in end-stage renal disease: a systematic review protocol
Discussion This review will summarize evidence regarding effects of interventions targeting arterial stiffness in ESRD patients. Our results will inform clinicians and researchers on the type of existing arterial stiffness-based interventions for ESRD patients and their potential efficacy and safety, with a goal to guide future clinical trials aimed at reducing adverse cardiovascular events. Systematic review registration PROSPERO CRD42016033463 (Source: Systematic Reviews)
Source: Systematic Reviews - July 19, 2016 Category: Global & Universal Source Type: research

Previously unidentified duplicate registrations of clinical trials: an exploratory analysis of registry data worldwide
Conclusions The ICTRP portal does not currently enable the unambiguous identification of trials across registries. Further research is needed to identify and verify the duplicates that currently go undetected. Sponsors, registries, and the ICTRP should consider actions to ensure duplicate registrations are easily identifiable. (Source: Systematic Reviews)
Source: Systematic Reviews - July 15, 2016 Category: Global & Universal Source Type: research

Cochrane: the unfinished symphony of research synthesis
Abstract The NHS needs valid information on the safety and effectiveness of healthcare interventions. Cochrane systematic reviews are an important source of this information. Traditionally, Cochrane has attempted to identify and include all relevant trials in systematic reviews on the basis that if all trials are identified and included, there should be no selection bias. However, a predictable consequence of the drive to include all trials is that some studies are included that are not trials (false positives). Including such studies in reviews might increase bias. More effort is needed to authenticate trials to...
Source: Systematic Reviews - July 14, 2016 Category: Global & Universal Source Type: research

The impact of cash transfers on social determinants of health and health inequalities in Sub-Saharan Africa: a systematic review protocol
Discussion This review will provide empirical evidence on the impact of CTs on SDoH to inform CT policy, implementation, and research in SSA. The protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Systematic review registration This protocol has been registered with the PROSPERO international prospective register of systematic reviews, reference CRD42015025015. (Source: Systematic Reviews)
Source: Systematic Reviews - July 13, 2016 Category: Global & Universal Source Type: research

A critical evaluation of the effectiveness of interventions for improving the well-being of caregivers of children with cerebral palsy: a systematic review protocol
Discussion The proposed systematic review will provide the empirical evidence of the efficacy of interventions for improving the well-being of caregivers of children with physical disabilities. This is important given the great need for evidenced-based care and the greater need to improve the health and well-being of caregivers. Systematic review registration PROSPERO CRD42016033975 (Source: Systematic Reviews)
Source: Systematic Reviews - July 13, 2016 Category: Global & Universal Source Type: research

Drug-based pain management in people with dementia after hip or pelvic fractures: a systematic review protocol
Discussion This review will provide a valuable overview on the current evidence on drug-based pain management for PwD in all settings who were conservatively treated after a hip or pelvic fracture. The review may expose a need to enhance pain management for PwD. It may also provide motivation for healthcare providers and policymakers to give this topic their attention and to facilitate further research by considering aspects of care transitions in all settings. Systematic review registration PROSPERO CRD42016037309 (Source: Systematic Reviews)
Source: Systematic Reviews - July 13, 2016 Category: Global & Universal Source Type: research

Appraisal of clinical practice guidelines for management of paediatric type 2 diabetes mellitus using the AGREE II instrument: a systematic review protocol
Discussion The results of this review will be disseminated through presentations at local, national, and international conferences and publication in a peer-reviewed journal. The results of this review can help improve the reporting of future guidelines, inform decisions of policy-makers to endorse CPGs, and affect the choice of guideline use in clinical practice. Systematic review registration PROSPERO CRD42016034187 (Source: Systematic Reviews)
Source: Systematic Reviews - July 13, 2016 Category: Global & Universal Source Type: research

The HCV care continuum among people who use drugs: protocol for a systematic review and meta-analysis
Discussion Through this review, we hope to quantify the proportion of PWUD at each progressive step and to help identify key individual, social, and structural points of leakage in the HCV care continuum for PWUD. In meeting these objectives, we will identify predictors to progress along the HCV care continuum, which can be used to inform policy to directly improve HCV care for PWUD. Systematic review registration PROSPERO CRD42016034113 (Source: Systematic Reviews)
Source: Systematic Reviews - July 11, 2016 Category: Global & Universal Source Type: research

Family experiences of infant and young child feeding in lower-income countries: protocol for a systematic review of qualitative studies
Discussion The findings will provide insight into the barriers and facilitators related to behavior that may hinder or enable implementation of interventions aimed at improving infant and young child feeding practices in lower-income settings. Systematic review registration PROSPERO CRD42016035677 (Source: Systematic Reviews)
Source: Systematic Reviews - July 8, 2016 Category: Global & Universal Source Type: research

Clinical and surgical risk factors in the development of proliferative vitreoretinopathy following retinal detachment surgery: a systematic review protocol
The objective of this systematic review is to identify and appraise the evidence on clinical and surgical risk factors and their utility in predicting the occurrence or worsening of PVR post-surgery. Methods Electronic databases and grey literature will be searched dating from 1980. Studies will be eligible if they include patients that underwent retinal reattachment surgery for rhegmatogenous retinal detachment (RRD), with and without PVR, and where risk factors were measured before or during surgery. Screening, data extraction and quality assessment will be performed independen...
Source: Systematic Reviews - July 8, 2016 Category: Global & Universal Source Type: research

Rethinking the assessment of risk of bias due to selective reporting: a cross-sectional study
Conclusions Our audit of user practice in Cochrane reviews suggests that the assessment of selective reporting in the current risk of bias tool does not work well. It is not always clear which outcomes were selectively reported or what the corresponding risk of bias is in the synthesis with missing outcome data. New tools that will make it easier for reviewers to convey this information are being developed. (Source: Systematic Reviews)
Source: Systematic Reviews - July 8, 2016 Category: Global & Universal Source Type: research

Study protocol for a systematic review of evidence for lifestyle interventions targeting smoking, sleep, alcohol/other drug use, physical activity, and healthy diet in people with bipolar disorder
Discussion The planned review will synthesize and evaluate the available evidence regarding the behavioral or psychosocial treatment of lifestyle-related behaviors in people with BD. From this review, we will identify gaps in our existing knowledge and research evidence about the management of unhealthy lifestyle behaviors in people with BD. We will also identify potential opportunities to address lifestyle behaviors in BD, with a view to reducing the burden of physical ill-health in this population. Systematic review registration PROSPERO CRD42015019993 (Source: Systematic Reviews)
Source: Systematic Reviews - July 5, 2016 Category: Global & Universal Source Type: research

Effect of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and meta-analysis
Discussion Our study will provide a comprehensive systematic review and meta-analysis on the potential effects of CYP2C9, VKORC1, or CYP4F2 on the warfarin maintenance dose in children, exploring the feasibility of the development of pharmacogenetic-guided warfarin dosing algorithm for children on oral vitamin K antagonists. Systematic review registration The review has been registered with PROSPERO (registration number CRD42015016172). (Source: Systematic Reviews)
Source: Systematic Reviews - June 23, 2016 Category: Global & Universal Source Type: research

Publication of reviews synthesizing child health evidence (PORSCHE): a survey of authors to identify factors associated with publication in Cochrane and non-Cochrane sources
Conclusions Key reasons for publishing in Cochrane are its positive reputation and impact factor. Reasons for publishing in non-Cochrane sources include lack of familiarity or challenges with the Cochrane processes and desire to publish in a source more directly relevant to the topic of interest. End users looking for evidence in the form of SRs need to be aware that there is a vast number of SRs published across the medical literature. Efforts to optimize the identification of SRs in non-Cochrane sources (e.g., through effective labeling or protocol/review registration) and their content will help end users fin...
Source: Systematic Reviews - June 21, 2016 Category: Global & Universal Source Type: research

Erratum to: A protocol for a systematic review of the diagnostic accuracy of blood markers, synovial fluid, and tissue testing in periprosthetic joint infections (PJI)
(Source: Systematic Reviews)
Source: Systematic Reviews - June 20, 2016 Category: Global & Universal Source Type: research

How lay health workers tailor in effective health behaviour change interventions: a protocol for a systematic review
This study aims to develop a better understanding of the effective implementation of tailoring in lay health worker interventions by appraising evidence and synthesising studies that report evaluations of tailored interventions. Method Health and psychology electronic databases (EMBASE, CINAHL, MEDLINE and PsycINFO) will be searched. Reference lists of included studies will also be searched. For articles that are deemed to be potentially relevant, we will employ a ‘cluster searching’ technique in order to identify all published papers related to a relevant interventio...
Source: Systematic Reviews - June 16, 2016 Category: Global & Universal Source Type: research

Clinical effectiveness of cell therapies in patients with chronic liver disease and acute-on-chronic liver failure: a systematic review protocol
This study will systematically review the evidence on clinical effectiveness of cell therapies in patients. Methods All types of study design that investigate the effectiveness of cell therapies (haematopoietic, mesenchymal and unsorted cell types) of autologous or allogeneic origin and/or the use of granulocyte colony-stimulating factor in patients with CLD including ACLF will be included (except case reports). Both autologous and allogenic cell types will be included. The primary outcomes of interest are survival, model for end-stage liver disease score, quality of life and adv...
Source: Systematic Reviews - June 14, 2016 Category: Global & Universal Source Type: research

The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol
Discussion This review will summarize evidence for the effectiveness of interventions used to reduce obesity risk in SCBT. This has significant implications for SCBT, as it can identify gaps in knowledge and provide insights into the development of new interventions to manage obesity in survivors, which may improve their outcomes. Systematic review registration PROSPERO CRD42015025909 (Source: Systematic Reviews)
Source: Systematic Reviews - June 14, 2016 Category: Global & Universal Source Type: research

Quality metrics in solid organ transplantation: protocol for a systematic scoping review
Discussion The results of this review will guide the development, selection, and validation of appropriate quality metrics necessary to drive quality improvement in transplantation. Systematic review registration PROSPERO CRD42016035353. (Source: Systematic Reviews)
Source: Systematic Reviews - June 14, 2016 Category: Global & Universal Source Type: research

Domains of quality for clinical ethics case consultation: a mixed-method systematic review
This article describes a rigorous protocol for compiling the diverse literature on CEC, analyzing it with a quality measurement lens, and seeking a set of potential quality domains for CEC based on areas of existing, but hitherto unrecognized, consensus in the literature. Methods/design This mixed-method systematic review will follow a sequential pattern: scoping review, qualitative synthesis, and then a quantitative synthesis. The scoping review will include categorizing all quality measures for CEC discussed in the literature, both quantitative and qualitative. The qualitative ...
Source: Systematic Reviews - June 7, 2016 Category: Global & Universal Source Type: research

The application of health literacy measurement tools (collective or individual domains) in assessing chronic disease management: a systematic review protocol
Discussion This systematic review will be one of several key contributions central to a global evidence-based strategy funded by the Canadian Institutes of Health Research (CIHR) for measuring HL in patients with asthma and COPD, highlighting the gaps and inconsistencies of domains between existing tools. The knowledge generated from this review will provide the team information on (1) the five-domain model and cross domains, (2) underlying constructs, (3) tool length, (4) time for completion, (5) reading level, and (6) format for development of the proposed tool. Other aspects of the published validation studie...
Source: Systematic Reviews - June 7, 2016 Category: Global & Universal Source Type: research

Effectiveness and content analysis of interventions to enhance medication adherence in hypertension: a systematic review and meta-analysis protocol
The objective of this systematic review is to evaluate the effectiveness of medication adherence interventions for hypertension. In addition, we aim to explore what barriers and facilitators in the interventions may have been targeted and how these might be related to the effect size on blood pressure (BP). Methods This review is a hypertension-specific update to the previous Cochrane Review by Nieuwlaat et al. (2014) on interventions to enhance medication adherence. A systematic literature search will be carried out, and two authors will independently screen titles and abstracts...
Source: Systematic Reviews - June 7, 2016 Category: Global & Universal Source Type: research

Factors contributing to chronic ankle instability: a protocol for a systematic review of systematic reviews
Discussion It is expected that this review will clarify the cause of contradicting findings in the literature and facilitate future research directions. Systematic review registration PROSPERO CRD42016032592. (Source: Systematic Reviews)
Source: Systematic Reviews - June 7, 2016 Category: Global & Universal Source Type: research

Adverse effects of extracorporeal carbon dioxide removal (ECCO 2 R) for acute respiratory failure: a systematic review protocol
Discussion In the UK, the current access to the use of ECCO2R is possible only with special arrangements for clinical governance, consent and for audit or research. Current evidence on ECCO2R suggests that there are a number of well-recognised complications which vary greatly across studies. This systematic review will consolidate the existing knowledge on adverse effects resulting from the use of ECCO2R. Systematic review registration PROSPERO CRD42015023503. (Source: Systematic Reviews)
Source: Systematic Reviews - June 7, 2016 Category: Global & Universal Source Type: research

Correlates of mobile screen media use among children aged 0–8: protocol for a systematic review
This study will identify correlates of mobile screen-viewing among children in five categories: (i) child biological and demographic correlates, (ii) behavioural correlates, (iii) family biological and demographic correlates, (iv) family structure-related correlates and (v) socio-cultural and environmental correlates. PRISMA statement will be used for ensuring transparency and scientific reporting of the results. Discussion This study will identify the correlates associated with increased mobile screen media use among young children through the systematic review of published peer...
Source: Systematic Reviews - June 3, 2016 Category: Global & Universal Source Type: research

Protocol for a systematic review of the efficacy of epidermal grafting for wound healing
Discussion This is a timely systematic review, and the finding of this systematic review is expected to guide research and clinical practice aimed at improving wound care. Systematic review registration PROSPERO CRD42016033051 (Source: Systematic Reviews)
Source: Systematic Reviews - June 3, 2016 Category: Global & Universal Source Type: research

What approaches to social prescribing work, for whom, and in what circumstances? A protocol for a realist review
Discussion This realist review will explore why mechanisms of social prescribing work, for what groups of people and their impact on enrolment, attendance and adherence to programmes. The use of realist approaches to detail the social prescribing process is novel and will offer insights into effective transfer of patients. Systematic review registration PROSPERO CRD42016039491 (Source: Systematic Reviews)
Source: Systematic Reviews - June 3, 2016 Category: Global & Universal Source Type: research

Economic evidence for the prevention and treatment of atopic eczema: a protocol for a systematic review
Discussion The systematic review is being undertaken to identify the type of economic evidence available, summarise the results of the available economic evidence and critically appraise the quality of economic evidence currently available to inform future economic modelling and resource allocation decisions about interventions to prevent or treat eczema. We aim to use the review to offer guidance about how to gather economic evidence in studies of eczema and/or what further research is necessary in order to inform this. Systematic review registration PROSPERO CRD42015...
Source: Systematic Reviews - May 27, 2016 Category: Global & Universal Source Type: research

Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol
The objective of this systematic review is to compare the efficacy and safety of regenerative cell therapies in preclinical models of PAH as well as assess study quality to inform future clinical studies. Methods We will include preclinical studies of PAH in which a regenerative cell type was administered and outcomes compared to a disease control. The primary outcome will be pulmonary hemodynamics as assessed by measurement of right ventricular systolic pressure and/or mean pulmonary arterial pressure. Secondary outcomes will include mortality, survival, right ventricular remode...
Source: Systematic Reviews - May 25, 2016 Category: Global & Universal Source Type: research

Pre-admission interventions to improve outcome after elective surgery—protocol for a systematic review
Discussion This systematic review will determine whether different types of interventions administered before elective surgery are effective in improving postoperative outcomes. It will also determine which components or combinations of components would form the most effective prehabilitation intervention. Systematic review registration PROSPERO CRD42015019191 (Source: Systematic Reviews)
Source: Systematic Reviews - May 23, 2016 Category: Global & Universal Source Type: research

SWIFT-Review: a text-mining workbench for systematic review
Conclusions Text-mining and machine learning software such as SWIFT-Review can be valuable tools to reduce the human screening burden and assist in problem formulation. (Source: Systematic Reviews)
Source: Systematic Reviews - May 23, 2016 Category: Global & Universal Source Type: research

The magnitude and mechanisms of the weekend effect in hospital admissions: A protocol for a mixed methods review incorporating a systematic review and framework synthesis
Discussion The weekend effect is a complex phenomenon that has major implications for the organisation of health services. Its magnitude and underlying mechanisms have been subject to heated debate. Published literature reviews have adopted restricted scopes or methods and mainly focused on quantitative evidence. This proposed review intends to provide a comprehensive and in-depth synthesis of diverse evidence to inform future policy and research aiming to address the weekend effect. Systematic review registration PROSPERO 2016: CRD42016036487 (Source: Systematic Reviews)
Source: Systematic Reviews - May 21, 2016 Category: Global & Universal Source Type: research

Clearing the air: protocol for a systematic meta-narrative review on the harms and benefits of e-cigarettes and vapour devices
Discussion Meta-narrative synthesis has the unique capacity to expose the debates that are influencing the interpretation of empirical studies on vapour devices. We seek to “clear the air” with an even-handed review of the evidence and an understanding of the tensions within public health so that we can offer clear-headed recommendations for policy, regulation, and future research. Systematic review registration PROSPERO CRD42015025267 (Source: Systematic Reviews)
Source: Systematic Reviews - May 21, 2016 Category: Global & Universal Source Type: research

Brazilian oral herbal medication for osteoarthritis: a systematic review protocol
Discussion This is the first study that will evaluate the use of herbal medications used in Brazil for the treatment of pain caused by osteoarthritis. The results could guide prescribers in decision-making in clinical practice, to inform the patients with pain caused by osteoarthritis in relation to effective and safe treatment options and to inform the managers of the public health system which of the plants could actually be financed by the Brazilian government. Systematic review registration PROSPERO 42015019793 (Source: Systematic Reviews)
Source: Systematic Reviews - May 21, 2016 Category: Global & Universal Source Type: research

Community-onset sepsis and its public health burden: a systematic review
Conclusions The lack of a valid standard approach for defining sepsis makes it difficult to determine the true incidence of COS. Differences in case ascertainment contribute to the variation in incidence of COS. The evidence on COS is limited in terms of the number and quality of studies. This review highlights the urgent need for an accurate and standard method for identifying sepsis. Future studies need to improve the methodological shortcomings of previous research in terms of case definition, identification, and surveillance practice. Systematic review registration ...
Source: Systematic Reviews - May 18, 2016 Category: Global & Universal Source Type: research

Evaluation of the Cochrane tool for assessing risk of bias in randomized clinical trials: overview of published comments and analysis of user practice in Cochrane and non-Cochrane reviews
Conclusions The Cochrane tool has become the standard approach to assess risk of bias in randomized clinical trials but is frequently implemented in a non-recommended way. Based on published comments and how it is applied in practice in systematic reviews, the tool may be further improved by a revised structure and more focused guidance. (Source: Systematic Reviews)
Source: Systematic Reviews - May 10, 2016 Category: Global & Universal Source Type: research