Informal carers ’ experience and outcomes of assistive technology use in dementia care in the community: a systematic review protocol
DiscussionA systematic review of quantitative, qualitative and mixed methods evidence of informal carers ’ experience of AT use in dementia in the community will be carried out. It is anticipated that this will highlight (1) investigations on impact of AT use on carers, (2) outcome measures and experience questionnaires that have been used and (3) the types of studies carried out so far on this topic . The results from the review will be presented in a summary matrix of common types (e.g. mobile phones, alarms) and uses (e.g. communication, safety, personal care) of AT in dementia care and also identify AT that is no...
Source: Systematic Reviews - July 3, 2019 Category: International Medicine & Public Health Source Type: research

Assessing trauma care health systems in low- and middle-income countries, a protocol for a systematic literature review and narrative synthesis
This study aims to conduct a narrative synthesis of a systematic search of the literature on the assessment of trauma care health systems in LMICs in order to inform the further development of trauma care health system assessment.MethodsThe review will include primary quantitative, qualitative or mixed method studies and secondary literature reviews. No restriction will be placed on language or date. Reports and publications identified from the grey literature including from relevant national and international health organisations will be included. Articles will be screened by two independent reviewers with a third reviewe...
Source: Systematic Reviews - July 2, 2019 Category: International Medicine & Public Health Source Type: research

Correction to: Information needs in people with diabetes mellitus: a systematic review
Following publication of the original article [1], the authors opted to revise Table  1. Below is the updated version of the table. (Source: Systematic Reviews)
Source: Systematic Reviews - July 2, 2019 Category: International Medicine & Public Health Source Type: research

Educational outcomes of children in contact with social care in England: a systematic review
ConclusionsDespite employing a search across 16 databases supplemented with additional searches of other online sources, we found only seven studies that met our inclusion criteria. This review throws into sharp relief the urgent need to conduct more population-level research into the educational prospects of children in contact with CSC services.Systematic review registrationPROSPEROCRD42018089755 (Source: Systematic Reviews)
Source: Systematic Reviews - June 28, 2019 Category: International Medicine & Public Health Source Type: research

Effect of mobile text message reminders on routine childhood vaccination: a systematic review and meta-analysis
ConclusionThis review highlights the potential benefits of incorporating mobile text message reminders into the standard management of childhood immunizations, especially in low- and middle-income countries. The frequency and timing of the text message reminders are also crucial in determining the effectiveness of text message reminders. Hence, mHealth interventions deserve more attention as a potential innovation to improve healthcare programs.Systematic review registrationPROSPEROCRD42017074230 (Source: Systematic Reviews)
Source: Systematic Reviews - June 28, 2019 Category: International Medicine & Public Health Source Type: research

Effects of walking speed on gait biomechanics in healthy participants: a systematic review and meta-analysis
ConclusionsThis review identified that speed affected the gait patterns of different populations with respect to the amplitude of spatiotemporal parameters, joint kinematics, joint kinetics, and ground reaction forces. Specifically, most of the values analyzed decreased at slower speeds and increased at faster speeds. Therefore, the effects of speed on gait patterns should also be considered when comparing the gait analysis of pathological individuals with normal or control ones. (Source: Systematic Reviews)
Source: Systematic Reviews - June 27, 2019 Category: International Medicine & Public Health Source Type: research

Health economic evaluation in orthotics and prosthetics: a systematic review protocol
DiscussionThis protocol has been purposefully designed to summarise the existing evidence and appraise the methodological approaches used and the quality of the health economic evaluations in orthotics and prosthetics. What we learn from this review will be used to guide further work in this area and design more rigorous health economic evaluations into the future.Systematic review registrationPROSPERO CRD42018116910. (Source: Systematic Reviews)
Source: Systematic Reviews - June 27, 2019 Category: International Medicine & Public Health Source Type: research

Introducing RAPTOR: RevMan Parsing Tool for Reviewers
ConclusionsThis software, despite being limited, illustrates how the efforts of reviewers meticulously extracting study data can be improved, disseminated and reused with little additional effort. (Source: Systematic Reviews)
Source: Systematic Reviews - June 26, 2019 Category: International Medicine & Public Health Source Type: research

Protocol on a systematic review of qualitative studies on asthma treatment challenges experienced in Sub-Saharan Africa
DiscussionThis systematic review will provide an overview of reported challenges in the treatment of asthma in Sub-Saharan Africa from 2008 to 2018. The review is expected to provide information that will help form the basis for future research, policy development and practice in treatment of asthma.Systematic review registrationPROSPERO CRD42018095802 (Source: Systematic Reviews)
Source: Systematic Reviews - June 25, 2019 Category: International Medicine & Public Health Source Type: research

Effectiveness and acceptability of methods of communicating the results of clinical research to lay and professional audiences: protocol for a systematic review
DiscussionDeveloping the search strategy for this review has been challenging as many of the concepts (patients, clinicians, clinical studies, and communication) are widely used in literature that is not relevant for inclusion in our review. We expect there will be limited comparative evidence, spread over a wide range of approaches, comparators and populations and, therefore, do not anticipate being able to carry out meta-analysis.Systematic review registrationInternational Prospective Register of Systematic Reviews PROSPERO (CRD42019137364). (Source: Systematic Reviews)
Source: Systematic Reviews - June 25, 2019 Category: International Medicine & Public Health Source Type: research

Palliative care interventions in intensive care unit patients – a systematic review protocol
DiscussionThis review will provide insight into the implementation of palliative care in ICU, elucidate differences between countries and health systems, reveal most effective models, and contribute to identifying research priorities to improve outcomes.Systematic review registrationInternational Prospective Register of Systematic reviews PROSPERO (CRD42018094315) (Source: Systematic Reviews)
Source: Systematic Reviews - June 22, 2019 Category: International Medicine & Public Health Source Type: research

Accurate GFR in obesity —protocol for a systematic review
DiscussionThis systematic review might help to inform clinicians on the best equation to use in patients with obesity and CKD for staging of CKD and for medication dosing. If no equation is deemed suitable, this review will form a basis for future studies of GFR in obese individuals.Systematic review registrationPROSPEROCRD42018104345 (Source: Systematic Reviews)
Source: Systematic Reviews - June 22, 2019 Category: International Medicine & Public Health Source Type: research

Antibiotic treatment for ocular toxoplasmosis: a systematic review and meta-analysis: study protocol
DiscussionThe strength of our study will lie in the exhaustive and systematic nature of the literature search, as well as in its methods for assessing quality and analyzing RCT data. Considering the controversial efficacy of the treatment for OT, our study will contribute to improving the existing evidence on the effectiveness of different antibiotics. Future studies may be conducted to increase physicians ’ awareness of antibiotic therapies, improving the health of patients with OT.Systematic review registrationPROSPERO CRD42018085468. (Source: Systematic Reviews)
Source: Systematic Reviews - June 20, 2019 Category: International Medicine & Public Health Source Type: research

Usability and acceptability of four systematic review automation software packages: a mixed method design
ConclusionThis study identified a number of considerations which systematic reviewers can use as a basis of their decision which software to use when performing the citation screening and dispute resolution steps of a systematic review. (Source: Systematic Reviews)
Source: Systematic Reviews - June 20, 2019 Category: International Medicine & Public Health Source Type: research

A question of trust: can we build an evidence base to gain trust in systematic review automation technologies?
ConclusionWe discuss adoption barriers with the goal of providing tool developers with guidance as to how to design and report such evaluations and for end users to assess their validity. Further, we discuss approaches to formatting and announcing publicly available datasets suitable for assessment of automation technologies and tools. Making these resources available will increase trust that tools are non-inferior or superior to current practice. Finally, we identify that, even with evidence that automation tools are non-inferior or superior to current practice, substantial set-up challenges remain for main stream integra...
Source: Systematic Reviews - June 18, 2019 Category: International Medicine & Public Health Source Type: research

Control group changes in objectively measured physical activity in primary care: protocol for a systematic review and meta-analysis
DiscussionThis systematic review and meta-analysis will determine the extent to which physical activity measurement alone is associated with changes in objectively measured physical activity levels in control groups in primary care. Findings from this study will inform future physical activity intervention research and practice. If measuring physical activity alone is associated with increases in physical activity levels that may be considered beneficial for health, this could indicate that measurement alone may be a low cost, efficient and effective method to increase  a proprotion of the population’s physical ...
Source: Systematic Reviews - June 18, 2019 Category: International Medicine & Public Health Source Type: research

Exercise therapy in the treatment of tendinopathies of the lower limbs: a protocol of a systematic review
DiscussionOther systematic reviews have been published about the prescription of exercise therapy in the treatment of tendinopathies of the lower limbs. However, the results of these reviews are limited to only one type of tendinopathy or specific exercise. Because some of these reviews are also outdated, this systematic review will investigate whether exercise therapy is more effective than any other type of intervention and if there is a best form of exercise therapy, considering modality, dose, and intensity, for the treatment of lower limb tendinopathies. Furthermore, this study will present data related to the sample ...
Source: Systematic Reviews - June 15, 2019 Category: International Medicine & Public Health Source Type: research

Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies
The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain.Methods/designWe designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the ...
Source: Systematic Reviews - June 14, 2019 Category: International Medicine & Public Health Source Type: research

Acceptance and commitment therapy for chronic pain: protocol of a systematic review and individual participant data meta-analysis
DiscussionThis collaborative meta-analysis of individual participant data from randomized controlled trials of ACT for chronic pain versus control conditions will demonstrate how the known benefits of ACT for chronic pain vary across different subtypes of the chronic pain population. The results of the meta-analyses will be based on a comprehensive search of multiple databases and will help to inform future clinical trials and decision-making on the use of ACT in chronic pain and improve the quality, design, and reporting of future trials in this field.Systematic review registrationPROSPERO CRD42019120901. (Source: Systematic Reviews)
Source: Systematic Reviews - June 14, 2019 Category: International Medicine & Public Health Source Type: research

Naloxone interventions in opioid overdoses: a systematic review protocol
DiscussionOur review will include the most up-to-date available data including ultra-potent opioids to inform the current response to the opioid epidemic, addressing the limitations of recent reviews. We anticipate limitations relating to study heterogeneity. We will disseminate study results widely to update overdose treatment guidelines and naloxone dosing in Take Home Naloxone programs. (Source: Systematic Reviews)
Source: Systematic Reviews - June 11, 2019 Category: International Medicine & Public Health Source Type: research

Immunotherapy with check-point inhibitors (CPI) in adult malignancies: a protocol for the systematic review of the quality of economic analyses
DiscussionThe systematic review will aim to provide an overview of the quality of economic analyses evaluating CPIs for the treatment of malignancies in adult patients. Any systemic or recurrent deficiencies in methodological or reporting quality will be described and used to inform recommendations for improved reporting of economic analyses.Systematic review registrationThis review will not be registered with PROSPERO, it does not meet the eligibility criterion of addressing an outcome of the direct patient or clinical relevance. (Source: Systematic Reviews)
Source: Systematic Reviews - June 11, 2019 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of randomized trials of knee arthroplasty decision aids and shared decision-making approaches
This study will characterize shared decision-making (SDM) approaches in knee arthroplasty randomized clinical trials and will summarize their effects of SDM on clinical and patient-reported outcomes. We anticipate this review will bring to light knowledge gaps and inform further research into the design and use of shared decision-making approaches in lower extremity arthroplasty.Systematic review registrationPROSPEROCRD42019123586 (Source: Systematic Reviews)
Source: Systematic Reviews - June 8, 2019 Category: International Medicine & Public Health Source Type: research

Development of a program theory for clinical pathways in hospitals: protocol for a realist review
The objective of this realist review is to develop a program theory for CPWs in hospitals.MethodsThis is a protocol for a realist review. The review will use a six-step iterative process to develop a program theory for CPWs in hospitals: (1) development of a preliminary program theory; (2) search strategy and literature search; (3) study selection and appraisal; (4) data extraction; (5) data analysis and synthesis; and (6) stakeholder engagement. In addition to searching the gray literature and contacting authors, we will search electronic databases such as MEDLINE, NHSEED, CINAHL EBSCO, HMIC, and PsycINFO. Studies will be...
Source: Systematic Reviews - June 8, 2019 Category: International Medicine & Public Health Source Type: research

Living alone and positive mental health: a systematic review
ConclusionsThis review allows a limited look at the association between living alone and positive mental health. Because the number of included studies was low and the quality of evidence varied across studies, further research is warranted. (Source: Systematic Reviews)
Source: Systematic Reviews - June 7, 2019 Category: International Medicine & Public Health Source Type: research

Telemedicine infectious diseases consultations and clinical outcomes: a systematic review and meta-analysis protocol
DiscussionA number of studies have documented the feasibility of telemedicine for infectious diseases, but a synthesis of clinical outcomes data with telemedicine infectious diseases consultation has not been performed. This systematic review will analyze many clinical outcomes of telemedicine infectious diseases consultation. The findings of this study will add to established literature about feasibility of telemedicine consultation by synthesizing the evidence for clinical effectiveness.Systematic review registrationPROSPEROCRD42018105225 (Source: Systematic Reviews)
Source: Systematic Reviews - June 7, 2019 Category: International Medicine & Public Health Source Type: research

Efficacy of commercially available biological agents for the topical treatment of cervical intraepithelial neoplasia: a systematic review
ConclusionAmong the topical agents studied, 5-FluoroUracil showed good remission rates above 80%. Varying results seen in this review is due to the differences in quality of the design between studies. Large-scale and less biaised studies are needed to elucidate the true efficacy and safety of topical agents in the treatment of CIN. (Source: Systematic Reviews)
Source: Systematic Reviews - June 7, 2019 Category: International Medicine & Public Health Source Type: research

Protocol for a scoping review of age-related health conditions among geriatric populations in sub-Saharan Africa
(Source: Systematic Reviews)
Source: Systematic Reviews - June 7, 2019 Category: International Medicine & Public Health Source Type: research

Predictors of 1-year mortality in adult lung transplant recipients: a systematic review and meta-analysis
DiscussionThe results from this study may inform future guidelines on the selection of candidates and donors for transplantation and predictive model development and inform the decision-making process that the physician and patient undertake together. Furthermore, through the conduction of this review, we can identify the limitations with the current best evidence, which will encourage the need for studies with a better methodology to reassess the predictors of mortality. (Source: Systematic Reviews)
Source: Systematic Reviews - June 3, 2019 Category: International Medicine & Public Health Source Type: research

Effectiveness of whey protein supplements on the serum levels of amino acid, creatinine kinase and myoglobin of athletes: a systematic review and meta-analysis
ConclusionThe findings revealed that the clinical evidence supports the effectiveness of WPS as a positive ergogenic aid on athletes ’ amino acids, creatinine kinase and myoglobin. (Source: Systematic Reviews)
Source: Systematic Reviews - May 31, 2019 Category: International Medicine & Public Health Source Type: research

Study-based registers reduce waste in systematic reviewing: discussion and case report
ConclusionWhilst helping prioritise and conduct systematic reviews, SBRs improve quality. Those funding information specialists for literature reviewing could reasonably stipulate the resulting SBR to be delivered for dissemination and use beyond the life of the project. (Source: Systematic Reviews)
Source: Systematic Reviews - May 30, 2019 Category: International Medicine & Public Health Source Type: research

Individual participant data (IPD)-level meta-analysis of randomised controlled trials among dark-skinned populations to estimate the dietary requirement for vitamin D
DiscussionAs dark-skinned population subgroups are at increased risk of vitamin D deficiency, further investigation of dietary recommendations for vitamin D in these subgroups is needed. We strongly believe that application of an IPD-based meta-analysis is a highly strategic approach by which to undertake some of this further investigation. Such IPD-based analysis, however, will need collaboration across the principal investigators of the identified RCTs meeting with the eligibility criteria, and the availability of this study protocol will be important to highlight the potential of IPD-based analysis for estimation of the...
Source: Systematic Reviews - May 28, 2019 Category: International Medicine & Public Health Source Type: research

Epidemiology, prevention, diagnosis, treatment, and outcomes for psychosocial problems in patients and families affected by non-intellectually impairing craniofacial malformation conditions: a systematic review protocol of qualitative data
DiscussionBecause the quality of research on psychosocial problems in craniofacial malformation conditions is known to be fraught with methodological problems, inconsistencies, and considerable knowledge gaps, we anticipate difficulties, which may limit the review questions able to be answered. We hope to produce a survey relevant to all non-intellectually impaired craniofacially deformed patients and their families and outline knowledge gaps and prioritise areas for clinical investigation.Systematic review registration: PROSPERO CRD42018093021Universal trial number: U1111-1211-8153 (Source: Systematic Reviews)
Source: Systematic Reviews - May 27, 2019 Category: International Medicine & Public Health Source Type: research

Mesenchymal stem cells for sensorineural hearing loss: protocol for a systematic review of preclinical studies
The objective of the proposed systematic review is to examine the efficacy of MSCs as a therapy for SNHL in animal models.MethodsWe will include preclinical animal studies of SNHL in which MSCs are administered, and outcomes are compared against MSC-na ïve controls. The primary outcome will include audiologic tests that are routinely used in experimental studies of hearing loss, such as auditory brainstem response (ABR) and distortion product otoacoustic emissions testing (DPOAE). Secondary outcomes will include histology, microscopy, gene protei n expression, and behavioral responses of animals. Electronic searches o...
Source: Systematic Reviews - May 25, 2019 Category: International Medicine & Public Health Source Type: research

Does stage of illness influence recovery-focused outcomes after psychological treatment in bipolar disorder? A systematic review protocol
DiscussionThis review will contribute to the literature by expanding upon previous reviews and potentially inform the psychosocial treatment of established BD. Implications include assisting clinicians, consumers and researchers to identify and select interventions most appropriate to recovery-focused goals based on individuals ’ clinical status.Systematic review registrationPROSPERO CRD42016037868 (Source: Systematic Reviews)
Source: Systematic Reviews - May 25, 2019 Category: International Medicine & Public Health Source Type: research

Psychological interventions for people with psychotic experiences: protocol for a systematic review and meta-analysis
DiscussionThe identification of effective psychological interventions and of specific components associated with intervention effectiveness will augment existing evidence that can inform the development of a new, tailored intervention to improve outcomes related to psychotic symptoms, anxiety and depression, distress, functioning, and quality of life.Systematic review registrationPROSPEROCRD42016033869 (Source: Systematic Reviews)
Source: Systematic Reviews - May 23, 2019 Category: International Medicine & Public Health Source Type: research

Decision aids that facilitate elements of shared decision making in chronic illnesses: a systematic review
ConclusionsDAs for selected chronic conditions are mostly designed to transfer information about options and their harms and benefits. The extent to which their support of SDM key elements relates to their impact on SDM outcomes could not be ascertained.Systematic review registrationPROSPERO registration number:CRD42016050320. (Source: Systematic Reviews)
Source: Systematic Reviews - May 20, 2019 Category: International Medicine & Public Health Source Type: research

Experiential learning for primary healthcare workers in low- and middle-income countries: a scoping review protocol
DiscussionWe anticipate finding a significant number of studies on the applications of experiential learning in resource-limited settings. Findings will be disseminated through publication in a peer-reviewed journal, peer presentations as well as presentations at relevant conferences. (Source: Systematic Reviews)
Source: Systematic Reviews - May 20, 2019 Category: International Medicine & Public Health Source Type: research

Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis  protocol
DiscussionHEV-infected animals are likely to transmit this virus to humans in Africa, as studies have already shown in developed countries. This systematic review and meta-analysis will provide a clear picture of the epidemiology of HEV in animals in Africa, to better understand this infection and to respond adequately to the epidemic challenges that often afflict Africa.Systematic review registrationPROSPERO,CRD42018087684. (Source: Systematic Reviews)
Source: Systematic Reviews - May 20, 2019 Category: International Medicine & Public Health Source Type: research

Epidemiology of respiratory viral infections in people with acute respiratory tract infections in Africa: the VARIAFRICA systematic review and meta-analysis protocol
DiscussionThis systematic review and meta-analysis is based on published data and therefore does not require ethical approval. This work will serve as a basis for the development of strategies for prevention and control ARTI in Africa and will also serve to identify data gaps and guide future investigations. The final report will be published in peer-reviewed journals as a scientific article and presented in workshops, conferences, and scientific conferences.Systematic review registrationPROSPERO,CRD42018088261. (Source: Systematic Reviews)
Source: Systematic Reviews - May 20, 2019 Category: International Medicine & Public Health Source Type: research

Experiential peer support and its effects on desistance from delinquent behavior: protocol paper for a systematic realist literature review
DiscussionInvestigating the effects and the underlying mechanisms of support by experiential peers for individuals with delinquent behavior is relevant because the forensic setting has some unique features, and the involvement of service users might create even more tension than in other settings due to stigma and perceived risks. The findings that will be reported in the realist review will contribute to the knowledge of the effects of support by experiential peers and will provide insight into which aspects remain to be studied. It might also provide formal care institutions with guidance on whether to involve experienti...
Source: Systematic Reviews - May 18, 2019 Category: International Medicine & Public Health Source Type: research

Using mobile phones to improve young people ’s sexual and reproductive health in low- and middle-income countries: a systematic review protocol to identify barriers, facilitators and reported interventions
DiscussionThe systematic review will assist researchers and SRH professionals in understanding facilitators and barriers to implementing and increasing the uptake of mHealth interventions for SRH in LMICs. Finally, this review will provide more detailed information about embracing the use of mobile phones at different levels of the healthcare system for improving young people ’s SRH outcomes.Systematic review registrationPROSPERO CRD42018087585 (Source: Systematic Reviews)
Source: Systematic Reviews - May 18, 2019 Category: International Medicine & Public Health Source Type: research

Anticonvulsants for behavioral and psychological symptoms in dementia: protocol for a systematic review
DiscussionThis is a protocol for a systematic review addressing the anticonvulsant group of medications as a whole, and as such, our results will inform current clinical practice in the use of anticonvulsants for BPSD. It will also help clinicians and policy makers compare the efficacy of anticonvulsants compared to antidepressants and antipsychotics as well as identify areas which will need further study.Systematic review registrationPROSPEROCRD42017079826 (Source: Systematic Reviews)
Source: Systematic Reviews - May 18, 2019 Category: International Medicine & Public Health Source Type: research

The effects of exercise on cardiometabolic outcomes in women with polycystic ovary syndrome not taking the oral contraceptive pill: protocol for a systematic review and meta-analysis
DiscussionA large proportion of women are affected by PCOS. It is prudent to examine how CVD risk can be mitigated in this high-risk population, and this review aims to provide evidence-driven recommendations on the types of exercise interventions that are effective for this. The review will seek to provide recommendations regarding type, frequency and duration of exercise interventions to improve cardiometabolic profile in PCOS. The subgroup analysis may be able to highlight difference in intervention effects between normo-androgenic and hyper-androgenic profile.Limitations include heterogeneity across studies and a scarc...
Source: Systematic Reviews - May 16, 2019 Category: International Medicine & Public Health Source Type: research

Predisposing and protective factors influencing suicide ideation, attempt, and death in patients accessing substance use treatment: a systematic review and meta-analysis protocol
DiscussionThis systematic review will contribute to our knowledge of risk and protective factors for suicidality in patients before and after treatment. Understanding these factors will help define areas of research for further investigation to ultimately inform risk assessment and prevention strategies.Systematic review registrationPROSPERO (reference number: CRD42018076260). (Source: Systematic Reviews)
Source: Systematic Reviews - May 15, 2019 Category: International Medicine & Public Health Source Type: research

Medication adherence influencing factors —an (updated) overview of systematic reviews
ConclusionThis overview analyses factors that might impact adherence to oral therapies in adult patients with physical chronic diseases. Our overview suggests that there is a social gradient in adherence. However, for most factors, the evidence was not conclusive due to the risk of bias, inconsistency or imprecision. (Source: Systematic Reviews)
Source: Systematic Reviews - May 10, 2019 Category: International Medicine & Public Health Source Type: research

Factors influencing perceptions of private water quality in North America: a systematic review
ConclusionsUnderstanding the factors that shape perceptions of water quality among private water users is an important step in developing private water management policies to increase compliance towards water testing and treatment in Canada and the USA. As many jurisdictions in Canada and the USA do not have mandatory private water testing or treatment guidelines, delineating these factors is an important step in informing future research and guiding policy on the public health of private water systems. (Source: Systematic Reviews)
Source: Systematic Reviews - May 10, 2019 Category: International Medicine & Public Health Source Type: research

Is a fusobacterium nucleatum infection in the colon a risk factor for colorectal cancer?: a systematic review and meta-analysis protocol
The objective of this systematic review is to synthesize the epidemiological evidence on the association between infection with Fusobacterium nucleatum in the colon and colorectal cancer.MethodsThis systematic review will include observational studies (cohort, case-control, cross-sectional) in humans in which the role of Fusobacterium nucleatum in the etiology of colorectal cancer was investigated. MEDLINE, EMBASE, Web of Science, and Cochrane Database of Systematic Reviews will be searched using a comprehensive search strategy and manual screening of references. Two reviewers will independently identify eligible studies a...
Source: Systematic Reviews - May 10, 2019 Category: International Medicine & Public Health Source Type: research

Effects of school-based interventions on motivation towards physical activity in children and adolescents: protocol for a systematic review
DiscussionIn order to increase and maintain physical activity levels in children and adolescents, motivation towards physical activity should be sustained. It is anticipated that the results of this systematic review will provide information as to which strategies implemented in the school setting are effective in increasing students ’ motivation towards physical activity, and hence increase their physical activity during school and after-school hours.Systematic review registrationPROSPERO CRD42018110306 (Source: Systematic Reviews)
Source: Systematic Reviews - May 10, 2019 Category: International Medicine & Public Health Source Type: research

Demographic and risk group heterogeneity across the UNAIDS 90-90-90 targets: a systematic review and meta-analysis protocol
DiscussionThe results of our review will help elucidate factors associated with failure to achieve virological suppression in sub-Saharan Africa, as well as factors associated with failure to achieve each of the 90-90-90 goals. These data will help quantify the population-level effects of current HIV treatment interventions to improve strategies for maximizing virological suppression and ending the HIV epidemic.Systematic review registrationPROSPEROCRD42018089505. (Source: Systematic Reviews)
Source: Systematic Reviews - May 6, 2019 Category: International Medicine & Public Health Source Type: research

Evaluation of the impact of single-nucleotide polymorphisms on treatment response, survival and toxicity with cytarabine and anthracyclines in patients with acute myeloid leukaemia: a systematic review protocol
DiscussionIt is expected that clinical decisions for AML patients will consider evidence-based practices to contribute to better patient management. In this way, we will be able to define how to treat patients with AML to improve their survival and quality of life.Systematic review registrationPROSPEROCRD42018100750 (Source: Systematic Reviews)
Source: Systematic Reviews - May 3, 2019 Category: International Medicine & Public Health Source Type: research