Effect of mushrooms on obesity in animal models: study protocol for a systematic review and meta-analysis
AbstractBackgroundObesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body weight are uncertain. The aim of this systematic review is to determine the efficacy of mushrooms in weight loss in animal preclinical models.MethodThis is a systematic review of preclinical studies of animal models of obesity (any type of non-aquatic mammal), which were exposed to edible and medicinal mushrooms orally in comparison with the control. The following databases will be used: MEDLINE (PubM...
Source: Systematic Reviews - November 25, 2019 Category: International Medicine & Public Health Source Type: research

The impact of later eating rhythm on childhood adiposity: protocol for a systematic review
DiscussionThe planned systematic review will investigate the association between later eating rhythm and adiposity in children and adolescents. Understanding the best meal size, timing of energy intake and meal frequency across the evening time for maintaining healthy weight in children is important in order to give parents the best advice to help prevent adulthood obesity and associated chronic diseases in their children.Systematic review registrationPROSPEROCRD42019134187. (Source: Systematic Reviews)
Source: Systematic Reviews - November 25, 2019 Category: International Medicine & Public Health Source Type: research

Defining the concept of family caregiver burden in patients with schizophrenia: a systematic review protocol
DiscussionThe result of this systematic review will help present the comprehensive definition of the family caregiver burden in patients with schizophrenia according to its evolutionary trend.Systematic review registrationPROSPEROCRD42018099372 (Source: Systematic Reviews)
Source: Systematic Reviews - November 25, 2019 Category: International Medicine & Public Health Source Type: research

Evidence on nutritional therapy practice guidelines and implementation in adult critically ill patients: a scoping review protocol
DiscussionWe hope to find studies on the implementation of nutritional therapy practice guidelines in adult critically ill patients and its impact on nutritional practices, patient outcomes, and health care costs. The results of this review will be disseminated through presentations in research seminars, conferences, and congresses and will also be available electronically and in print.Systematic review registrationPROSPEROCRD42017058864 (Source: Systematic Reviews)
Source: Systematic Reviews - November 25, 2019 Category: International Medicine & Public Health Source Type: research

Infrared pupillometry to help predict neurological outcome for patients achieving return of spontaneous circulation following cardiac arrest: a systematic review protocol
DiscussionIRP requires rudimentary skill and is objective and repeatable. As a clinical prognostication modality, it may be utilised early, when the strategy ’s other modalities are not recommended. Corroboration in the evidence would promote early use of IRP and a reduction in ICU bed days.Systematic review registrationPROSPEROCRD42018118180 (Source: Systematic Reviews)
Source: Systematic Reviews - November 24, 2019 Category: International Medicine & Public Health Source Type: research

Implementation strategies to improve preconception and antenatal care for tobacco smoking, alcohol consumption and weight management: a systematic review protocol
DiscussionThis review will identify which implementation strategies are effective in improving the routine provision of preconception and antenatal care for tobacco smoking, alcohol consumption and weight management. Such a review will be of interest to service providers, policy makers and implementation researchers seeking to improve women ’s modifiable risk factors in preconception and antenatal care settings.Systematic review registrationPROSPERO CRD42019131691 (Source: Systematic Reviews)
Source: Systematic Reviews - November 22, 2019 Category: International Medicine & Public Health Source Type: research

Acceptability, feasibility, and efficacy of Internet cognitive behavioral therapy (iCBT) for pediatric obsessive-compulsive disorder: a systematic review
ConclusionAt present, evidence regarding acceptability, feasibility, and efficacy of iCBT for pediatric OCD is limited. Results are promising but need to be confirmed and refined in further research.Systematic review registrationPROSPEROCRD4201808587 (Source: Systematic Reviews)
Source: Systematic Reviews - November 19, 2019 Category: International Medicine & Public Health Source Type: research

Interventions for oropharyngeal dysphagia in acute and critical care: a protocol for a systematic review and meta-analysis
DiscussionNo systematic review has attempted to summarise the evidence for oropharyngeal dysphagia interventions in acute and critical care. Results of the proposed systematic review will inform practice and the design of future clinical trials.Systematic review registrationPROSPERO CRD 42018116849 (http://www.crd.york.ac.uk/PROSPERO/) (Source: Systematic Reviews)
Source: Systematic Reviews - November 19, 2019 Category: International Medicine & Public Health Source Type: research

Many continuous variables should be analyzed using the relative scale: a case study of β 2 -agonists for preventing exercise-induced bronchoconstriction
ConclusionsCompared with the absolute scale, the relative scale captures more effectively the variation in the effects of β2-agonists on exercise-induced FEV1-declines. The absolute scale has been used in the analysis of FEV1 changes and may have led to sub-optimal statistical analysis in some cases. The choice between the absolute and relative scale should be determined based on biological reasoning and empirical testing to identify the scale that leads to lower heterogeneity. (Source: Systematic Reviews)
Source: Systematic Reviews - November 18, 2019 Category: International Medicine & Public Health Source Type: research

Screening for thyroid dysfunction and treatment of screen-detected thyroid dysfunction in asymptomatic, community-dwelling adults: a systematic review
AbstractBackgroundThis systematic review was conducted to inform the Canadian Task Force on Preventive Health Care recommendations on screening for thyroid dysfunction (TD). The review sought to answer key questions on the benefits and harms of screening for TD, patients ’ values and preferences for screening, and the benefits and harms of treating screen-detected TD.MethodsThis review followed Canadian Task Force on Preventive Health Care methods, which include the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. The search strategy used for benefits and harms of screening and tre...
Source: Systematic Reviews - November 17, 2019 Category: International Medicine & Public Health Source Type: research

Performance and usability of machine learning for screening in systematic reviews: a comparative evaluation of three tools
ConclusionsThe workload savings afforded in the automated simulation came with increased risk of missing relevant records. Supplementing a single reviewer ’s decisions with relevance predictions (semi-automated simulation) sometimes reduced the proportion missed, but performance varied by tool and SR. Designing tools based on reviewers’ self-identified preferences may improve their compatibility with present workflows.Systematic review registrationNot applicable. (Source: Systematic Reviews)
Source: Systematic Reviews - November 14, 2019 Category: International Medicine & Public Health Source Type: research

Assessing the accuracy of machine-assisted abstract screening with DistillerAI: a user study
ConclusionsThe accuracy of DistillerAI is not yet adequate to replace a human screener temporarily during abstract screening for systematic reviews. Rapid reviews, which do not require detecting the totality of the relevant evidence, may find semi-automation tools to have greater utility than traditional systematic reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - November 14, 2019 Category: International Medicine & Public Health Source Type: research

Comparative effectiveness and safety of pharmacological and non-pharmacological interventions for insomnia: an overview of reviews
AbstractBackgroundThis review aimed to assess the existing evidence regarding the clinical effectiveness and safety of pharmacological and non-pharmacological interventions in adults with insomnia and identify where research or policy development is needed.MethodsMEDLINE, Embase, PsycINFO, The Cochrane Library, and PubMed were searched from inception until June 14, 2017, along with relevant gray literature sites. Two reviewers independently screened titles/abstracts and full-text articles, and a single reviewer with an independent verifier completed charting, data abstraction, and quality appraisal.ResultsA total of 64 sys...
Source: Systematic Reviews - November 14, 2019 Category: International Medicine & Public Health Source Type: research

Risk of bias tools in systematic reviews of health interventions: an analysis of PROSPERO-registered protocols
ConclusionsWhile RoB tool selection for RCT was consistent, with the Cochrane RoB Tool being the most frequently reported in PROSPERO protocols, RoB tools for NRS varied widely. Results suggest a need for more education and awareness on the appropriate use of RoB tools for NRS. Given the heterogeneity of study designs comprising NRS, multiple RoB tools tailored to specific designs may be required. (Source: Systematic Reviews)
Source: Systematic Reviews - November 14, 2019 Category: International Medicine & Public Health Source Type: research

A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome
ConclusionA consistent finding among all papers included in this review was impaired NK cell cytotoxicity, suggesting that it is a reliable and appropriate cellular model for continued research in ME/CFS patients. Aberrations in NK cell lytic protein levels were also reported. Although additional research is recommended, current research provides a foundation for subsequent investigations. It is possible that NK cell abnormalities can be used to characterise a subset of ME/CFS due to the heterogeneity of both the illness itself and findings between studies investigating specific features of NK function. (Source: Systematic Reviews)
Source: Systematic Reviews - November 13, 2019 Category: International Medicine & Public Health Source Type: research

Evidence-based models of care for the treatment of alcohol use disorder in primary health care settings: protocol for systematic review
DiscussionThis systematic review and meta-analysis aims to guide improvement of design and implementation of evidence-based models of care for the treatment of alcohol use disorder in primary health care settings. The evidence will define which models are most promising and will guide further research.Protocol registration numberPROSPERO CRD42019120293. (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2019 Category: International Medicine & Public Health Source Type: research

Epidemiology of gastric cancer in Africa: a systematic review and meta-analysis protocol
DiscussionThis review will provide relevant data on the current burden of gastric cancer in Africa.Systematic review registrationPROSPEROCRD42019130348. (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2019 Category: International Medicine & Public Health Source Type: research

Mapping evidence on the burden and distribution of childhood obesity in sub-Saharan Africa: a scoping review protocol
DiscussionWe anticipate that the proposed study will contribute to the existing body of knowledge on childhood obesity, identify gaps in knowledge on the topic, inform future research direction, and provide evidence-based information to strengthen health systems and policies on childhood obesity towards achieving the WHO global target of halting the rise in obesity by 2025. (Source: Systematic Reviews)
Source: Systematic Reviews - November 12, 2019 Category: International Medicine & Public Health Source Type: research

An overview of systematic reviews of complementary and alternative therapies for infantile colic
ConclusionThere is clearly a need for larger and more methodologically sound RCTs to be conducted on the effectiveness of some CAM therapies for IC. Particular focus on probiotics in non-breastfed infants is pertinent.Systematic review registrationPROSPERO: CRD42018092966. (Source: Systematic Reviews)
Source: Systematic Reviews - November 10, 2019 Category: International Medicine & Public Health Source Type: research

An overview of systematic reviews of economic evaluations of pharmacy-based public health interventions: addressing methodological challenges
ConclusionsEconomic evaluations of pharmacy-based public health interventions seem to follow most economic quality criteria, but there are still some issues in certain key areas to improve. These findings may assist in improving the design of pilot trials of economic evaluations in pharmacy, leading to robust evidence for payers. Based on the findings, we propose a methodological approach for the economic evaluation of pharmacy-based public health interventions.Systematic review registrationPROSPEROCRD42016032768 (Source: Systematic Reviews)
Source: Systematic Reviews - November 10, 2019 Category: International Medicine & Public Health Source Type: research

Functional recovery with peripheral nerve block versus general anesthesia for upper limb surgery: a systematic review protocol
DiscussionWe aim to summarize the available evidence comparing functional recovery with peripheral nerve block versus general anesthesia for upper limb surgery. These data will inform the design of a trial on the topic.Systematic review registrationPROSPEROCRD42018116298 (Source: Systematic Reviews)
Source: Systematic Reviews - November 10, 2019 Category: International Medicine & Public Health Source Type: research

Prognostic prediction models for pregnancy complications in women with gestational diabetes: a protocol for systematic review, critical appraisal and meta-analysis
This study will systematically review published prognostic prediction models for pregnancy complications in women with GDM, describe their characteristics, compare performance and assess methodological quality and applicability.MethodsStudies will be identified by searching MEDLINE and Embase electronic databases. Title and abstract screening, full-text review and data extraction will be completed independently by two reviewers. The included studies will be systematically assessed for risk of bias and applicability using appropriate tools designed for prediction modelling studies. Extracted data will be tabulated to facili...
Source: Systematic Reviews - November 10, 2019 Category: International Medicine & Public Health Source Type: research

The best treatment option(s) for adult and elderly patients with chronic primary musculoskeletal pain: a protocol for a systematic review and network meta-analysis
DiscussionCPMP is a disabling condition for which several interventions exist. To our knowledge, this is the first network meta-analysis to systematically compare all available evidence. This is required by national health institutions to inform their decisions about the best available treatment option(s) with regard to efficacy and safety outcomes.Systematic review registrationPROSPEROCRD42018096114 (Source: Systematic Reviews)
Source: Systematic Reviews - November 8, 2019 Category: International Medicine & Public Health Source Type: research

The association between depressive symptoms or depression and health outcomes in adults with low back pain with or without radiculopathy: protocol of a systematic review
DiscussionThe impact of depressive symptoms and depression on health- and health care-related outcomes for LBP with or without radiculopathy will be assessed and quantified. Findings of this systematic review will advance our understanding of LBP prognosis, and guide decision-making and improve quality of care for adults with LBP.Systematic review registrationPROSPEROCRD42019130047 (Source: Systematic Reviews)
Source: Systematic Reviews - November 7, 2019 Category: International Medicine & Public Health Source Type: research

Type 2 diabetes and pre-diabetes mellitus: a systematic review and meta-analysis of prevalence studies in women of childbearing age in the Middle East and North Africa, 2000 –2018
ConclusionsT2DM and pre-DM are common in women of childbearing age in MENA countries. The high DM burden in this vital population group could lead to adverse pregnancy outcomes and acceleration of the intergenerational risk of DM. Our review presented data and highlighted gaps in the evidence of the DM burden in women of childbearing age, to inform policy-makers and researchers.Systematic review registrationPROSPERO CRD42017069231 (Source: Systematic Reviews)
Source: Systematic Reviews - November 7, 2019 Category: International Medicine & Public Health Source Type: research

Systematic review of the use of process evaluations in knowledge translation research
ConclusionsThere is widespread acceptance that the generalizability of quantitative trials of KT interventions would be significantly enhanced throughcomplementary process evaluations. However, this systematic review found that process evaluations are of mixed quality and lack theoretical guidance. Most process evaluation data collection occurred post-intervention undermining the ability to evaluate theprocess of implementation. Strong science and methodological guidance is needed to underpin and guide the design and execution of process evaluations in KT science.RegistrationThis study is not registered with PROSPERO. (Sou...
Source: Systematic Reviews - November 6, 2019 Category: International Medicine & Public Health Source Type: research

Intervention components, mediators, and mechanisms of change of Internet- and mobile-based interventions for post-traumatic stress disorder: protocol for a systematic review and meta-analysis
DiscussionThe results of this systematic review and meta-analysis might further contribute to the development of IMIs for PTSD by highlighting intervention components and mediators associated with their efficacy. Knowledge about the active ingredients might ultimately lead to more effective interventions and treatment packages, with implications for clinical practice and dissemination of these rather novel interventions.Systematic review registrationPROSPERO (CRD42019130314). (Source: Systematic Reviews)
Source: Systematic Reviews - November 6, 2019 Category: International Medicine & Public Health Source Type: research

How should systematic reviewers handle conference abstracts? A view from the trenches
ConclusionsUnder given circumstances, it is worthwhile to search for and include results from conference abstracts in systematic reviews. (Source: Systematic Reviews)
Source: Systematic Reviews - November 6, 2019 Category: International Medicine & Public Health Source Type: research

Socioeconomic position and body composition across the life course: a systematic review protocol
DiscussionThe results of the review will summarise the existing evidence on social inequalities in body composition. Findings will identify gaps in knowledge and where further research is required.Systematic review registrationPROSPEROCRD42019119937 (Source: Systematic Reviews)
Source: Systematic Reviews - November 6, 2019 Category: International Medicine & Public Health Source Type: research

Mapping evidence on the distribution of paediatric cancers in sub-Saharan Africa: a scoping review protocol
The objective of this study is to map evidence on the distribution of paediatric cancers in the SSA region.MethodA scoping review will be conducted to map literature on the distribution of paediatric cancers in SSA. An electronic literature search will be conducted from the following databases: PubMed, Google Scholar, EBSCOhost (CINAHL and Health Source) and World Health Organization (WHO)/International Agency for Research in Cancer (IARC) (GLOBOCAN databases). We will also search the reference lists of included studies to source relevant literature. A pilot search was conducted to determine the feasibility of the study. S...
Source: Systematic Reviews - November 6, 2019 Category: International Medicine & Public Health Source Type: research

Non-Interventional Factors Influencing Velopharyngeal Function For Speech In Initial Cleft Palate Repair: A Systematic Review Protocol
DiscussionThis systematic review may provide sufficient data to inform the development of a screening tool to predict the risk of velopharyngeal insufficiency prior to cleft palate repair. However, it is anticipated that these findings will provide the foundation for future studies in this area.Systematic review registrationRegistered on 19 December 2016 with PROSPEROCRD42017051624 (Source: Systematic Reviews)
Source: Systematic Reviews - November 4, 2019 Category: International Medicine & Public Health Source Type: research

Strategies for increasing participation in mail-out colorectal cancer screening programs: a systematic review and meta-analysis
ConclusionsInterventions that combine program-level changes incorporating the issue of advance notification and alternative screening tools with the involvement of primary health professionals through endorsement letters and telephone contact should lead to increases in kit return in mail-out CRC screening programs.Systematic review registrationThis review is registered with PROSPERO; registration number CRD42017064652 (Source: Systematic Reviews)
Source: Systematic Reviews - November 3, 2019 Category: International Medicine & Public Health Source Type: research

Influence of external contextual factors on the implementation of health and social care interventions into practice within or across countries —a protocol for a ‘best fit’ framework synthesis
DiscussionThe review will lead to a comprehensive framework for understanding the influence of external contextual factors on implementation, particularly when spreading health and social care interventions within or across countries. The framework is anticipated to help identify factors explaining the decline and variability in effectiveness of interventions and assessing the prospects of implementation effectiveness, when spreading interventions. We do not intend to only develop another stand-alone implementation framework but one that can be used in conjunction with existing frameworks. The framework can be honed and va...
Source: Systematic Reviews - November 3, 2019 Category: International Medicine & Public Health Source Type: research

New insulin delivery devices and glycemic outcomes in young patients with type 1 diabetes: a protocol for a systematic review and meta-analysis
This study protocol proposes a clear and transparent methodology for conducting a SRMA of the literature (1) to assess the effect of CSII versus MDI on glycemic and patient-reported outcomes (PROs) among young patients with T1D and (2) to identify health inequalities in the use of CSII.MethodsThis protocol was developed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P), the PRISMA-E (PRISMA-Equity 2012 Guidelines), and the Cochrane Collaboration Handbook. We will include randomized clinical trials and non-randomized studies published between January 2000 and June 2019 to a...
Source: Systematic Reviews - November 3, 2019 Category: International Medicine & Public Health Source Type: research

Health outcomes of iron supplementation and/or food fortification in iron-replete children aged 4 –24 months: protocol for a systematic review and meta-analysis
DiscussionRecommended iron supplementation and food fortification practices in high-income countries have been criticised for being both excessive and based on outdated or underpowered studies. This systematic review will build a case for revisiting iron intake guidelines for infants through the design of new trials where health effects of additional iron intake in iron-replete infants are the primary outcome.Systematic review registrationPROSPERO CRD42018093744. (Source: Systematic Reviews)
Source: Systematic Reviews - October 31, 2019 Category: International Medicine & Public Health Source Type: research

Satisfaction of Nigerian patients with health services: a protocol for a systematic review
DiscussionThe intended systematic review will provide information on how the satisfaction of patients with health services has earlier been described and assessed in Nigerian studies. It will establish if a gold standard method exists and synthesize information on topics which might be of special interest to patients. Review findings will enrich the debate on patient-centered care and overall performance of health quality standards in Nigeria.Systematic review registrationPROSPEROCRD42018108140 (Source: Systematic Reviews)
Source: Systematic Reviews - October 31, 2019 Category: International Medicine & Public Health Source Type: research

The effects of cell therapy on seizures in animal models of epilepsy: protocol for systematic review and meta-analysis of preclinical studies
DiscussionThe purpose of this systematic review is to assess and summarise the existing literature in the field of cell transplantation as a treatment for epilepsy in animal models. Efficacy will be measured by evaluating the reduction in seizure intervals, number, and duration, within animal models of epilepsy. Analysis of the existing literature will mark the achievement made in the field and locate the existing gaps, a process that will aid in the search for the next needed step.Systematic review registrationCRD42018103628 (Source: Systematic Reviews)
Source: Systematic Reviews - October 31, 2019 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of the use of qualitative comparative analysis for evaluative questions in public health research
DiscussionThis systematic review will provide an important map of the increasing use of QCA in public health intervention literature. This review will identify the current scope of research in this area, as well as assessing claims about the utility of the method for addressing complex causation in public health research. We will identify implications for better reporting of QCA methods in public health research and for reporting of case studies such that they can be used in future QCA studies.Systematic review registrationPROSPERO,CRD42019131910 (Source: Systematic Reviews)
Source: Systematic Reviews - October 31, 2019 Category: International Medicine & Public Health Source Type: research

Clinical significance of premature ventricular contraction among adult patients: protocol for a scoping review
DiscussionWe believe this scoping review will provide a general foundation of evidence on the potential significance of PVCs concerning its diagnostic and prognostic value among the adult patient population. The findings will allow us to map out research gaps on this topic that could shape future research and ultimately clinical practice.Scoping review registrationThis scoping review has been registered in the Open Science Framework (OSF), DOI:https://doi.org/10.17605/OSF.IO/GAVT2. (Source: Systematic Reviews)
Source: Systematic Reviews - October 31, 2019 Category: International Medicine & Public Health Source Type: research

The effects of adding angiotensin receptor neprilysin inhibitors to usual care in patients with heart failure: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
DiscussionThe present systematic review will have the potential to aid clinicians in decision-making and thereby, benefit patients with heart failure.Systematic review registrationPROSPEROCRD42019129336 (Source: Systematic Reviews)
Source: Systematic Reviews - October 30, 2019 Category: International Medicine & Public Health Source Type: research

Effectiveness and safety of inpatient versus extended venous thromboembolism (VTE) prophylaxis with heparin following major pelvic surgery for malignancy: protocol for a systematic review
DiscussionThis systematic review will aim to identify the postoperative period in which patients undergoing major pelvic surgery for malignancy are at further increased risk of VTE as a result of their surgery and the optimum duration of heparin VTE prophylaxis with heparin to reduce this risk. Determining this will allow evidence-based recommendations to be made for the optimum duration of heparin VTE prophylaxis post major pelvic surgery for malignancy, leading to improved standards of care that are consistent between different providers and institutions.Systematic review registrationIn accordance with guidelines, our sy...
Source: Systematic Reviews - October 29, 2019 Category: International Medicine & Public Health Source Type: research

Effects of aerobic exercise in the treatment of older adults with chronic musculoskeletal pain: a protocol of a systematic review
DiscussionThe results of this systematic review will provide a synthesis of the current evidence on the effects of aerobic exercise in the treatment of older adults with chronic musculoskeletal pain. In addition, this information can help health professionals in decision-making about the use of aerobic exercise in the treatment of older adults with chronic musculoskeletal pain.Ethics and disseminationThis systematic review was recorded prospectively, and the results will be part of a doctoral thesis to be published in a peer-reviewed international journal and possibly presented at international conferences.Systematic revie...
Source: Systematic Reviews - October 29, 2019 Category: International Medicine & Public Health Source Type: research

Interpersonal psychotherapy for perinatal women: a systematic review and meta-analysis protocol
The objective of this systematic review and meta-analysis is to evaluate the effectiveness, feasibility, and acceptability of IPT interventions to treat perinatal psychological distress and to summarize the evidence on predictors, mediators, and moderators of IPT.MethodsWe will include peer-reviewed studies that recruited perinatal women. The search strategy will involve the following databases: MEDLINE (Ovid), EMBASE (Ovid), PsycINFO (Ovid), Cochrane Central Register of Controlled Trials (Ovid), CINAHL with Full Text (EBSCO), Social Work Abstracts (EBSCO), SocINDEX with Full Text (EBSCO), Academic Search Complete (EBSCO),...
Source: Systematic Reviews - October 28, 2019 Category: International Medicine & Public Health Source Type: research

Impact of interventions on work-related outcomes for individuals with musculoskeletal injuries after road traffic crash: a systematic review protocol
DiscussionThis review will explore the effectiveness of interventions in individuals with traffic crash-related musculoskeletal injury on work-related outcomes and will act as a useful source for researchers, policy makers, and stakeholders when developing and implementing interventions in this group.Systematic review registrationPROSPEROCRD42018103746 (Source: Systematic Reviews)
Source: Systematic Reviews - October 28, 2019 Category: International Medicine & Public Health Source Type: research

Coronary artery bypass surgery plus medical therapy versus medical therapy alone for ischaemic heart disease: a protocol for a systematic review with meta-analysis and trial sequential analysis
DiscussionCoronary artery bypass surgery is invasive and can cause death, which is why its use must be thoroughly studied to determine if it yields a large enough long-term benefit for the thousands of patients receiving it every year.Systematic review registrationPROSPERO ID 131924 (Source: Systematic Reviews)
Source: Systematic Reviews - October 27, 2019 Category: International Medicine & Public Health Source Type: research

Psychological interventions for alcohol use disorders in people living with HIV/AIDS: a systematic review
ConclusionThis systematic review did not reveal large or sustained intervention effects of psychological interventions for either primary alcohol use or secondary HIV-related outcomes. Due to the methodological heterogeneity, we were unable to undertake a meta-analysis. Effectiveness trials of psychological interventions for AUDs in PLWH that include disaggregation of data by level of alcohol consumption, gender and age are needed. There is a need to standardise alcohol use outcome measures across studies and include objective biomarkers that provide a more accurate measure of alcohol consumption and are relatively free fr...
Source: Systematic Reviews - October 27, 2019 Category: International Medicine & Public Health Source Type: research

Measuring the impact of screening automation on meta-analyses of diagnostic test accuracy
ConclusionScreening prioritization coupled with stopping criteria in diagnostic test accuracy reviews can reliably detect when the screening process has identified a sufficient number of studies to perform the main meta-analysis with an accuracy within pre-specified tolerance limits. However, many of the systematic reviews did not identify a sufficient number of studies that the meta-analyses were accurate within a 2% limit even with exhaustive manual screening, i.e., using current practice. (Source: Systematic Reviews)
Source: Systematic Reviews - October 27, 2019 Category: International Medicine & Public Health Source Type: research

Risk of major bleeding during extended oral anticoagulation in patients with first unprovoked venous thromboembolism: a systematic review and meta-analysis protocol
DiscussionThe planned systematic review and meta-analysis will provide reliable estimates of the risk for major bleeding events during extended anticoagulation. This information will help inform patient prognosis and assist clinicians with balancing the risks and benefits of treatment to guide management of unprovoked VTE.Systematic review registrationPROSPEROCRD42019128597. (Source: Systematic Reviews)
Source: Systematic Reviews - October 27, 2019 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients
DiscussionOur review will be the first to assess direct and indirect evidence to assess the efficacy and rank the treatments available for new onset atrial fibrillation in critically unwell patients. Our review findings will be applicable to the care of people in a range of acute settings including, ICU, the emergency department and acute medical units.Systematic review registrationPROSPERO registry number: CRD42019121739. (Source: Systematic Reviews)
Source: Systematic Reviews - October 27, 2019 Category: International Medicine & Public Health Source Type: research

Evidence on food control in charitable food assistance programs: a systematic scoping review
ConclusionWith no previous comprehensive review to assess what is known about food control in the CFAPs, we undertook a scoping review, focusing on mapping the key concepts, including the main sources and types of evidence available. By drawing conclusions about the overall state of research activity and identifying research gaps and priorities in the existing literature, this study provides a baseline assessment of the CFAP research published in peer-reviewed journals from inception to 2018. (Source: Systematic Reviews)
Source: Systematic Reviews - October 24, 2019 Category: International Medicine & Public Health Source Type: research