Developing a framework for a novel multi-disciplinary, multi-agency intervention(s), to improve medication management in community-dwelling older people on complex medication regimens (MEMORABLE) ––a realist synthesis
DiscussionThis realist synthesis aims to develop a framework (underpinned by our programme theory) for a novel multi-disciplinary, multi-agency intervention(s), to improve medication management in community-dwelling older people on complex medication regimens.Systematic review registrationPROSPERO CRD42016043506 (Source: Systematic Reviews)
Source: Systematic Reviews - July 3, 2017 Category: International Medicine & Public Health Source Type: research

A systematic review of the processes used to link clinical trial registrations to their published results
ConclusionsThe linkage of trial registries to their corresponding publications continues to require extensive manual processes. We did not find that the use of automatic linkage has increased over time. Further investigation is needed to inform approaches that will ensure publications are properly linked to trial registrations, thus enabling efficient monitoring of trial reporting. (Source: Systematic Reviews)
Source: Systematic Reviews - July 3, 2017 Category: International Medicine & Public Health Source Type: research

The effects of chronic and acute physical activity on working memory performance in healthy participants: a systematic review with meta-analysis of randomized controlled trials
ConclusionsChronic PA can significantly improve WMP while acute PA cannot. The limiting factors for acute PA studies point to the diversity of working memory instruments utilized, unequal sample sizes between studies, and the sample age groups. Large-scale, high-quality RCTs are needed in order to provide generalizable and more powerful analysis between PA and WMP in a systematic approach. (Source: Systematic Reviews)
Source: Systematic Reviews - June 30, 2017 Category: International Medicine & Public Health Source Type: research

What determines the effects and costs of breast cancer screening? A protocol of a systematic review of reviews
DiscussionThis systematic review of reviews will examine the degree of variability in the effectiveness and cost-effectiveness of BCS programmes.Systematic review registrationPROSPEROCRD42016050764 andCRD42016050765 (Source: Systematic Reviews)
Source: Systematic Reviews - June 28, 2017 Category: International Medicine & Public Health Source Type: research

The association between child and adolescent emotional disorder and poor attendance at school: a systematic review protocol
DiscussionThis systematic review will provide a detailed synthesis of evidence regarding the relationship between childhood emotional disorder and poor attendance at school. Understanding this relationship has the potential to assist in the development of strategies to improve the identification of and intervention for this vulnerable group.Systematic review registrationPROSPEROCRD42016052961 (Source: Systematic Reviews)
Source: Systematic Reviews - June 28, 2017 Category: International Medicine & Public Health Source Type: research

An assessment of the factors affecting the commercialization of cell-based therapeutics: a systematic review protocol
DiscussionThrough a systematic search and appraisal of available literature, this review will identify key challenges in the commercialization pathway of cellular-based therapeutics and highlights significant barriers impeding successful clinical adoption. This will aid in creating an adaptable, acceptable, and harmonized approach supported by apposite regulatory frameworks and pertinent expertise throughout the respective stages of the adoption cycle to facilitate the adoption of new products and technologies in the industry. (Source: Systematic Reviews)
Source: Systematic Reviews - June 26, 2017 Category: International Medicine & Public Health Source Type: research

Stress ulcer prophylaxis versus placebo or no prophylaxis in adult hospitalised acutely ill patients —protocol for a systematic review with meta-analysis and trial sequential analysis
DiscussionThere is a need for a high-quality systematic review to summarise the benefits and harms of stress ulcer prophylaxis in hospitalised patients to inform practice and future research. Although stress ulcer prophylaxis is used worldwide, no firm evidence for benefit or harm as compared to placebo or no treatments has been established. Critical illness is a continuum not limited to the ICU setting, which is why it is important to assess the benefits and harms of stress ulcer prophylaxis in a wider perspective than exclusively in ICU patients.Systematic review registrationPROSPEROCRD42017055676 (Source: Systematic Reviews)
Source: Systematic Reviews - June 24, 2017 Category: International Medicine & Public Health Source Type: research

An investigation of the impact of using different methods for network meta-analysis: a protocol for an empirical evaluation
DiscussionThe results of this study will inform whether, in practice, the choice of network meta-analysis method matters, and if it does, in what situations differences in the results between methods might arise. The results from this research might also inform future simulation studies. (Source: Systematic Reviews)
Source: Systematic Reviews - June 24, 2017 Category: International Medicine & Public Health Source Type: research

Identifying approaches for assessing methodological and reporting quality of systematic reviews: a descriptive study
ConclusionsThe methods used to assess quality of SRs are diverse, and none has become universally accepted. The most commonly used quality assessment tools are AMSTAR, OQAQ, and PRISMA. As new tools and guidelines are developed to improve both the MQ and RQ of SRs, authors of methodological studies are encouraged to put thoughtful consideration into the use of appropriate tools to assess quality and reporting. (Source: Systematic Reviews)
Source: Systematic Reviews - June 19, 2017 Category: International Medicine & Public Health Source Type: research

Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery: protocol for a systematic review, meta-analysis, and trial sequential analysis
DiscussionThe results of this systematic review may help to inform clinical practice and also the design of future large-scale randomized trials.Systematic review registrationPROSPEROCRD42016035987 (Source: Systematic Reviews)
Source: Systematic Reviews - June 19, 2017 Category: International Medicine & Public Health Source Type: research

Development of a program theory for shared decision-making: a realist review protocol
DiscussionThe goal of the realist review will be to identify and refine a program theory for SDM through the identification of mechanisms which shape the characteristics of when, how, and why SDM will, and will not, work.Systematic review registrationPROSPEROCRD42017062609 (Source: Systematic Reviews)
Source: Systematic Reviews - June 17, 2017 Category: International Medicine & Public Health Source Type: research

Does metabolic syndrome predict surgical complications? A protocol for a systematic review and meta-analysis
This study will report and summarise adverse outcomes among adult patients with MetS undergoing surgery across a range of surgical specialties. Developing insights into outcomes of this population of interest is necessary to develop guidelines towards better management of surgical patients with metabolic syndrome.Systematic review registrationPROSPEROCRD42016051071 (Source: Systematic Reviews)
Source: Systematic Reviews - June 17, 2017 Category: International Medicine & Public Health Source Type: research

Psychological interventions for the treatment of depression, anxiety, alcohol misuse or anger in armed forces veterans and their families: systematic review and meta-analysis protocol
DiscussionThe review will examine the findings of existing intervention research for depression, anxiety, alcohol misuse or anger in armed forces veterans and their families, along with any effect sizes that may exist.Systematic review registrationPROSPEROCRD42016036676 (Source: Systematic Reviews)
Source: Systematic Reviews - June 15, 2017 Category: International Medicine & Public Health Source Type: research

Interventions to prevent hemodynamic instability during renal replacement therapy for acute kidney injury: a systematic review protocol
DiscussionHIRRT is a common complication of renal replacement therapy not only in ESKD but also in the critically ill AKI population. It can result in early discontinuation of dialysis, further organ injury from hypoperfusion, and possibly negatively impact renal recovery. This systematic review will synthesize the existing evidence on the interventions employed to predict or prevent episodes HIRRT in critically ill patients with RRT-requiring AKI. This systematic review will allow for an understanding the current evidence for interventions to limit HIRRT in AKI and, in doing so, may also highlight areas in need of further...
Source: Systematic Reviews - June 15, 2017 Category: International Medicine & Public Health Source Type: research

Access barriers to obstetric care at health facilities in sub-Saharan Africa —a systematic review
ConclusionDespite similarities in obstetric care barriers across sub-Saharan Africa, country-specific strategies are required to tackle the challenges mentioned. Governments need to develop strategies to improve healthcare systems and overall socioeconomic status of women, in order to tackle supply- and demand-side access barriers to obstetric care. It is also important that strategies adopted are supported by research evidence appropriate for local conditions. Finally, more research is needed, particularly, with regard to supply-side interventions that may improve the obstetric care experience of pregnant women.Systematic...
Source: Systematic Reviews - June 6, 2017 Category: International Medicine & Public Health Source Type: research

Parent experiences and information needs relating to procedural pain in children: a systematic review protocol
DiscussionTo our knowledge, no published review exists that comprehensively reports on the experiences and information needs of parents related to the management of their child ’s procedural pain and distress. A systematic review of parents’ experiences and information needs will help to inform strategies to empower them with the knowledge necessary to ensure their child’s comfort during a painful procedure.Systematic review registrationPROSPEROCRD42016043698 (Source: Systematic Reviews)
Source: Systematic Reviews - June 6, 2017 Category: International Medicine & Public Health Source Type: research

Protocol for a systematic review of the efficacy of fat grafting and platelet-rich plasma for wound healing
DiscussionThis review will provide robust evidence of the efficacy of fat grafting and PRP for wound healing. This is an emerging technique, and this review is expected to guide clinical practice and ongoing research aimed at improving wound care.Systematic review registrationPROSPEROCRD42016049881 (Source: Systematic Reviews)
Source: Systematic Reviews - June 6, 2017 Category: International Medicine & Public Health Source Type: research

Do outcomes reported in randomised controlled trials of joint replacement surgery fulfil the OMERACT 2.0 Filter? A review of the 2008 and 2013 literature
ConclusionsWe identified significant gaps in the measurement of OMERACT core outcome areas in TJR trials, despite the majority reporting outcome domains of pain and function. An international consensus of key stakeholders is needed to develop a core domain set for reporting of TJR trials.Systematic review registrationPROSPEROCRD42014009216 (Source: Systematic Reviews)
Source: Systematic Reviews - May 30, 2017 Category: International Medicine & Public Health Source Type: research

Perioperative antibiotics in pediatric cardiac surgery: protocol for a systematic review
DiscussionWe will report the results of this review in agreement with the PRISMA statement and disseminate our findings at relevant critical care and cardiology conferences and through publication in peer-reviewed journals. We will use this systematic review to inform clinical guidelines, which will be disseminated in a separate stand-alone publication.Study registration numberPROSPEROCRD42016052978C (Source: Systematic Reviews)
Source: Systematic Reviews - May 30, 2017 Category: International Medicine & Public Health Source Type: research

Ultrasound characteristics of the mid-portion of the Achilles tendon in runners: a systematic review protocol
DiscussionThis will be the first systematic review to summarise the existing evidence on ultrasound characteristics of the mid-portion of the Achilles tendon in recreational runners.Systematic review registrationPROSPEROCRD42016050509 (Source: Systematic Reviews)
Source: Systematic Reviews - May 30, 2017 Category: International Medicine & Public Health Source Type: research

Conclusions in systematic reviews of mammography for breast cancer screening and associations with review design and author characteristics
Conclusions about specific age groups were graded as favourable if they stated that there were meaningful benefits, that benefits of mammography outweighed harms, or that harms were inconsequential. The main outcome measures were the prop ortions of favourable conclusions relative to review design and author characteristics.ResultsFrom 59 conclusions identified in 50 reviews, 42% (25/59) were graded as favourable by two investigators. Among the conclusions produced by clinicians, 63% (12/19) were graded as favourable compared to 32% (13/40) from other authors. In the 50 –69 age group where the largest proportion of s...
Source: Systematic Reviews - May 22, 2017 Category: International Medicine & Public Health Source Type: research

Polypharmacy in multimorbid older adults: protocol for a systematic review
DiscussionThis review will help describe the various ways of conceptualizing polypharmacy and how it is associated with health outcomes. We have selected outcomes most relevant for public surveillance performed with administrative databases. Other positive and negative outcomes have been associated with polypharmacy but may not be included in the review.Systematic review registrationPROSPERO CRD42014014989 (Source: Systematic Reviews)
Source: Systematic Reviews - May 19, 2017 Category: International Medicine & Public Health Source Type: research

Comparison of the effect of oral care with four different antiseptics to prevent ventilator-associated pneumonia in adults: protocol for a network meta-analysis
DiscussionOral care to prevent ventilator-associated pneumonia has been widely used. The efficacy of usual oral antiseptics have been assessed mainly using traditional meta-analysis. However, it was unclear which oral care solution is best used for oral care and there were no head-to-head RCT to compare the efficacy of four antiseptics. The proposed network meta-analysis will compare four antiseptics and rank the results using network meta-analysis to decide which was the best.Systematic review registrationPROSPEROCRD42016038088 (Source: Systematic Reviews)
Source: Systematic Reviews - May 19, 2017 Category: International Medicine & Public Health Source Type: research

Epidemiology of diabetic foot disease and diabetes-related lower-extremity amputation in Australia: a systematic review protocol
This study aims to describe the protocol for a systematic review of the epidemiology of diabetic foot disease and diabetes-related lower-extremity amputation in Australia.Methods —searchThe systematic review will be performed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. PubMed and EMBASE will be searched for publications in any language and without restrictions to date. Two independent investigators will screen publications for eligibility, with publications reporting Australian population-based incidence or prevalence of diabetic foot disease or diabetes-related lowe...
Source: Systematic Reviews - May 18, 2017 Category: International Medicine & Public Health Source Type: research

Why are some people more fit than others? Correlates and determinants of cardiorespiratory fitness in adults: protocol for a systematic review
DiscussionBy consolidating and synthesizing the current research on possible individual and interpersonal correlates and determinants of CRF among adults worldwide, we aim to aid future public health actions, as well as identify gaps in our full understanding of what influences CRF.Systematic review registrationPROSPEROCRD42017055456. (Source: Systematic Reviews)
Source: Systematic Reviews - May 18, 2017 Category: International Medicine & Public Health Source Type: research

Barriers and facilitators of access to maternal services for women with disabilities: scoping review protocol
DiscussionWe anticipate to find relevant studies reporting evidence on the barriers and facilitators of access to maternal health services in Sub-Saharan Africa. The evidence obtained from the included studies when summarised will help guide future research. The study findings will be disseminated electronically and in print. In addition, it will be presented at conferences related to sexual reproductive health, maternal health care and reproductive health. (Source: Systematic Reviews)
Source: Systematic Reviews - May 16, 2017 Category: International Medicine & Public Health Source Type: research

Identifying models of delivery, care domains and quality indicators relevant to palliative day services: a scoping review protocol
DiscussionIdentifying, developing and implementing evidence-based quality indicators is critical to the evaluation and continued improvement of palliative care. Review findings will be used to support clinicians and policymakers make decisions on which quality indicators are most appropriate for evaluating day services at the patient and service level, and to identify areas for further research. (Source: Systematic Reviews)
Source: Systematic Reviews - May 16, 2017 Category: International Medicine & Public Health Source Type: research

An overview of systematic reviews of complementary and alternative therapies for fibromyalgia using both AMSTAR and ROBIS as quality assessment tools
ConclusionsOverall, five reviews scored 6 or above using the AMSTAR scale and the inter-rater agreement was good (83.6%), whereas seven reviews achieved a low risk of bias rating using ROBIS and the inter-rater agreement was fair (60.0%). No firm conclusions were drawn for efficacy of either spinal manipulation or homoeopathy for FM. There is limited evidence for topicalCapsicum, but further research is required. There is some evidence to support the effectiveness of acupuncture for FM, but further high-quality trials are needed to investigate its benefits, harms and mechanisms of action, compared with no or standard treat...
Source: Systematic Reviews - May 15, 2017 Category: International Medicine & Public Health Source Type: research

Paraquat and Parkinson ’s disease: a systematic review protocol according to the OHAT approach for hazard identification
DiscussionThis is the first time that the OHAT systematic review protocol will be applied to investigate a possible causal association between exposure to paraquat and PD. Results from this study could serve as basis for regulatory agencies to define paraquat levels of concern, supporting its risk assessment process.Systematic review registrationPROSPERO CRD42016050861 (Source: Systematic Reviews)
Source: Systematic Reviews - May 15, 2017 Category: International Medicine & Public Health Source Type: research

Cardioprotective potential of N -acetyl cysteine against hyperglycaemia-induced oxidative damage: a protocol for a systematic review
DiscussionAlthough several studies have shown that NAC can ameliorate hyperglycaemia-induced oxidative damage within the heart, this systematic review will be the first pre-registered synthesis of data to identify the cardioprotective potential of NAC against hyperglycaemia-induced oxidative damage. This result will help guide future research evaluating the cardioprotective role of NAC against DCM and better identify possible mechanisms of action for NAC to prevent oxidative damage with a diabetic heart.Systemic review registrationPROSPEROCRD42017055851. (Source: Systematic Reviews)
Source: Systematic Reviews - May 12, 2017 Category: International Medicine & Public Health Source Type: research

Behavioral interventions to promote adequate sleep among women: protocol for a systematic review and meta-analysis
DiscussionThis review will provide valuable information to those interested in promoting adequate sleep among women and, hopefully, encourage additional research in this important field to promote maternal, fetal, and infant health.Systematic review registrationThe study protocol was registered in PROSPERO in October 2016 (CRD42016049538). (Source: Systematic Reviews)
Source: Systematic Reviews - May 11, 2017 Category: International Medicine & Public Health Source Type: research

The effects of clinical supervision on supervisees and patients in cognitive-behavioral therapy: a study protocol for a systematic review
This study will include a systematic review of the literature to identify studies that have empirically investigated the effects of supervision on supervised psychotherapists and/or the supervisees ’ patients. A comprehensive search strategy will be conducted to identify published controlled studies indexed in the MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases. Data on supervision outcomes in both psychotherapists and their patients will be extracted, synthesized, and reported. Ri sk of bias and quality of the included studies will be assessed systematically.DiscussionThis systematic review will rigorously...
Source: Systematic Reviews - May 11, 2017 Category: International Medicine & Public Health Source Type: research

Protocol of a scoping review on knowledge translation competencies
DiscussionWe expect the identified KT competencies to contribute to the KT science by providing positive outcomes in practice, policy, education, and future research. Incorporation of the core KT competencies may enhance safety, effectiveness of clinical care, and quality of health outcomes; contribute to and facilitate collaboration among practitioners, knowledge users, knowledge brokers, researchers, employers, and educators; improve education of healthcare professionals and inform policy-making process; benefit practitioners by guiding their KT professional development to become effective at moving evidence into practic...
Source: Systematic Reviews - May 2, 2017 Category: Global & Universal Source Type: research

Perioperative adjuvant corticosteroids for post-operative analgesia in elective knee surgery – A systematic review
DiscussionThis systematic review of the perioperative adjunctive use of corticosteroids will assess the analgesic effects, post-operative nausea and vomiting, opiate consumption, infection rates and time till discharge and assess whether adjunctive corticosteroids should be encouraged in elective knee surgery.Systematic review registrationPROPSERO CRD42016049336 (Source: Systematic Reviews)
Source: Systematic Reviews - April 27, 2017 Category: Global & Universal Source Type: research

Prevention of cervical cancer in HIV-seropositive women from developing countries: a systematic review protocol
DiscussionThis review will address the gap in evidence by systematically reviewing the published literature on the different prevention modalities being used to prevent cervical cancer in HIV-seropositive women in developing countries. The findings may be used to inform evidence-based guidelines for prevention of cervical cancer in seropositive women as well as future research.Systematic review registrationPROSPEROCRD42017054678. (Source: Systematic Reviews)
Source: Systematic Reviews - April 24, 2017 Category: Global & Universal Source Type: research

MOrtality and infectious complications of therapeutic E ndo VA scular interventional radiology: a systematic and meta-analysis protocol
DiscussionThis systematic review will provide a synthesis of EIR complications. The spotlighted results will be analyzed in order to provide a state-of-knowledge synopsis of the current evidence base in relation to the epidemiology of the infectious complications after EIR. In the event of conclusive results, our findings will serve as a reference background to assess guidelines on reality of the problem of the infections linked to endovascular interventional radiology and to formulate of assumptions and propose preventive measures, based on the results of our investigations. These propositions will aim to reduce the risk ...
Source: Systematic Reviews - April 24, 2017 Category: Global & Universal Source Type: research

N of 1 trials and the optimal individualisation of drug treatments: a systematic review protocol
DiscussionThis review will provide new insights into the clinical utility of N of 1 drug trials in helping participants find the most acceptable treatment as defined by patients and clinicians based on the selected outcome measures and the perspectives of participants involved in such trials. Findings from this review will inform the development of a stakeholder workshop and guidance to help physicians find the optimum therapy for their patients and will help guide future research on N of 1 trials.Systematic review registrationPROSPEROCRD42016032452 (Source: Systematic Reviews)
Source: Systematic Reviews - April 24, 2017 Category: Global & Universal Source Type: research

Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data
AbstractBackgroundGaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course. Plasma chitotriosidase activity and CC chemokine ligand 18 (CCL18) have been exchangeably used for monitoring GD activity and response to enzyme replacement therapy in conjunction with clinical assessment. Yet, a large-scale head-to-head comparison of these two biomarkers is currently lacking. We propose a collaborative systematic review with meta-analysis of individual participant data (IPD) ...
Source: Systematic Reviews - April 20, 2017 Category: Global & Universal Source Type: research

Protocol: a systematic review of studies developing and/or evaluating search strategies to identify prognosis studies
DiscussionThis systematic review will identify all existing validated prognosis search filters and synthesise evidence about their applicability and performance. These findings will identify if current filters provide a proficient means of searching electronic bibliographic databases or if further prognosis filters are needed and can feasibly be developed for systematic searches of prognosis studies. (Source: Systematic Reviews)
Source: Systematic Reviews - April 20, 2017 Category: Global & Universal Source Type: research

Updated systematic review: associations between proximity to animal feeding operations and health of individuals in nearby communities
ConclusionsFew studies reported an association between surrogate clinical outcomes and AFO proximity for respiratory tract-related outcomes. There were no consistent dose-response relationships between surrogate clinical outcome and AFO proximity. A new finding was that Q fever in goats is likely associated with an increased Q fever risk in community members. The review results for the non-respiratory health outcomes were inconclusive because only a small number of studies were available or the between-study results were inconsistent.Systematic review registrationPROSPEROCRD42014010521 (Source: Systematic Reviews)
Source: Systematic Reviews - April 18, 2017 Category: Global & Universal Source Type: research

Which learning activities enhance physiotherapy practice? A systematic review protocol of quantitative and qualitative studies
AbstractBackgroundLearning activities are fundamental for the development of expertise in physiotherapy practice. Continuing professional development (CPD) encompasses formal and informal learning activities undertaken by physiotherapists. Identifying the most efficient and effective learning activities is essential to enable the profession to assimilate research findings and improve clinical skills to ensure the most efficacious care for clients. To date, systematic reviews on the effectiveness of CPD provide limited guidance on the most efficacious models of professional development for physiotherapists. The aim of this ...
Source: Systematic Reviews - April 17, 2017 Category: Global & Universal Source Type: research

Patient- and family-centered performance measures focused on actionable processes of care for persistent and chronic critical illness: protocol for a systematic review
AbstractBackgroundApproximately 5 to 10% of critically ill patients transition from acute critical illness to a state of persistent and in some cases chronic critical illness. These patients have unique and complex needs that require a change in the clinical management plan and overall goals of care to a focus on rehabilitation, symptom relief, discharge planning, and in some cases, end-of-life care. However, existing indicators and measures of care quality, and tools such as checklists, that foster implementation of best practices, may not be sufficiently inclusive in terms of actionable processes of care relevant to thes...
Source: Systematic Reviews - April 17, 2017 Category: Global & Universal Source Type: research

Effectiveness of current policing-related mental health interventions in England and Wales and Crisis Intervention Teams as a future potential model: a systematic review
The objectives of the review are firstly to identify and report research on the relevant interventions, nationally and internationally and then secondly to consider, when possible, which interventions or aspects of those interventions are effective. This is judged with regard to changes in mental health status or service use and future offending behaviour.The approaches to be considered have gained a good deal of support and funding over recent years, and this review will provide a systematic review of the underpinning research evidence to inform future commissioning, service design and investment decisions. (Source: Systematic Reviews)
Source: Systematic Reviews - April 17, 2017 Category: Global & Universal Source Type: research

The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysis  protocol
ConclusionsThis review will systematically and comprehensively review diagnostic and management practices associated with the Spitz nevus. This overview of current literature will hopefully provide the foundation for future standardization of clinical practice.Systematic review registrationPROSPEROCRD42016034045 (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2017 Category: Global & Universal Source Type: research

Early identification of patients requiring massive transfusion, embolization, or hemostatic surgery for traumatic hemorrhage: a systematic review protocol
DiscussionThis systematic review will describe the availability of multivariable prediction models and summarize evidence regarding predictors that can be used to identify the need for intervention in patients with traumatic hemorrhage.Systematic review registrationPROSPEROCRD42017054589 (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2017 Category: Global & Universal Source Type: research

Determining the gaps between Cochrane reviews and trials of effectiveness of interventions for acute respiratory infections: an audit
ConclusionsWe identified many RCT topics that have not been systematically reviewed. They need to be addressed in a separate process to establish their priority to clinicians. (Source: Systematic Reviews)
Source: Systematic Reviews - April 13, 2017 Category: Global & Universal Source Type: research

Approaches to interpreting and choosing the best treatments in network meta-analyses
We present ranking approaches ’ merits and limitations and provide an example of how to apply the results of a NMA to clinical practice. (Source: Systematic Reviews)
Source: Systematic Reviews - April 12, 2017 Category: Global & Universal Source Type: research

What do register-based studies tell us about migrant mental health? A scoping review
ConclusionsThis review systematically charts the register-based studies on migrants ’ mental health for the first time. It shows the main topics and gaps in knowledge in this research domain, discusses the disadvantages of register-based studies, and suggests new directions for forthcoming studies. (Source: Systematic Reviews)
Source: Systematic Reviews - April 11, 2017 Category: Global & Universal Source Type: research

Therapeutic interventions for alcohol dependence in non-inpatient settings: a systematic review and network meta-analysis (protocol)
DiscussionThis network meta-analysis aims to appraise and summarize the total evidence of therapeutic interventions for alcohol-dependent patients that require support for detoxification and can be treated in the community. The evidence will determine which combination of interventions are most promising for current practice and further investigation.Systematic review registrationPROSPEROCRD42016049779 (Source: Systematic Reviews)
Source: Systematic Reviews - April 11, 2017 Category: Global & Universal Source Type: research

Protocol for a systematic review of the factors associated with binge drinking among adolescents and young adults
This study aims to identify and organise the factors associated with binge drinking among young people aged 15 to 24  years; and to provide a framework to further understand these factors in order to better target prevention strategies.Methods/designThis systematic review of the literature will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. The databases PubMed, Embase, PsycINFO and Social Care will be searched for articles published between 1 January 2006 and 31 December 2015. Our search focuses on studies examining the risk factors for binge drinking among you...
Source: Systematic Reviews - April 11, 2017 Category: Global & Universal Source Type: research