Atrial fibrillation and Ventricular Tachyarrhythmias: Advancements for better outcomes.
Authors: Gheini A, Pourya A, Pooria A Abstract Cardiac arrhythmias are associated with several cardiac diseases and are prevalent in people with or without structural and valvular abnormalities. Ventricular arrhythmias (VA) can be life threating and its onset requires immediate medical attention. Similarly, atrial fibrillation and flutter lead to stroke, heart failure and even death. Optimal treatment of VA is very variable and depends on the medical condition associated with the rhythm disorder (which includes reversible causes such as myocardial ischemia or pro-arrhythmic drugs). While an implanted cardioverter d...
Source: Cardiovascular and Hematological Disorders Drug Targets - October 3, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Updated understanding of platelets in thrombosis and hemostasis: the roles of integrin PSI domains and their potential as therapeutic targets.
Authors: MacKeigan DT, Ni T, Shen C, Stratton TW, Ma W, Zhu G, Bhoria P, Ni H Abstract Platelets are small blood cells known primarily for their ability to adhere and aggregate at injured vessels to arrest bleeding. However, when triggered under pathological conditions, the same adaptive mechanism of platelet adhesion and aggregation may cause thrombosis, a primary cause of heart attack and stroke. Over recent decades, research has made considerable progress in uncovering the intricate and dynamic interactions that regulate these processes. Integrins are heterodimeric cell surface receptors expressed on all metazoa...
Source: Cardiovascular and Hematological Disorders Drug Targets - October 3, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Antihyperglycemic activity and safety assessment of the aqueous extract of Scorzonera undulata ssp deliciosa aerial parts in rat.
CONCLUSION: the present study demonstrates the antihyperglycemic effect of Scorzonera undulata in diabetic rats which could be involved through improvement of liver structure and function. In addition, the dose used is not toxic. Finally, the extract contains large amounts of bioactive compounds, mainly polyphenols. PMID: 32860366 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 31, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Evaluating Mortality Rate and Associated Parameters in Patients with Acute Coronary Syndrome.
CONCLUSION: Our study reports risk factors associated with mortality in ACS patients. Advanced and timely therapeutic measurements are likely to reduce the incidence of mortality in these patients. PMID: 32646364 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 12, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Is the detection of factor IX inhibitors in hemophilia B orphan than factor VIII inhibitors in hemophilia A? A concise, systematic review.
CONCLUSION: Consistent with the lower frequency of hemophilia B and the lower development of inhibitors in hemophilia B compared to hemophilia A, it was concluded that hemophilia B had not neglected in Iran. It seems to be rational that each country, check rates of detection of inhibitors in hemophilia B to identify whether it has neglected or not. PMID: 32611303 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 3, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Association between Serum Vitamin D Level and Echocardiographic Abnormalities in Patients with Thalassemia Major.
CONCLUSIONS: It seems that vitamin D deficiency in patients with TM is associated with systolic but not diastolic dysfunctions, possibly as consequences of related biochemical abnormalities. PMID: 32611304 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 3, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Overview of Covid-19 regarding the cardiovascular situation in the light of current reports.
Authors: Aydin S, Akkoc RF, Aydin S Abstract Nowadays coronavirus disease 2019 (Covid-19) is increasing mortality all over the world mercilessly. We are learning almost every day about its new symptoms and that it mutates quickly. This disease ties us up and leaves us desperate. Death from this disease has increased in patients who had with pre-existing medical conditions, especially cardiovascular ones, by eliminating the angiotensin-converting enzyme (ACE)-2 receptor in the lungs. Also, ACE1 and angiotensin receptor blockers (ARB) may stimulate ACE2 expression and worse the prognosis. Intravenous infusions of ACE...
Source: Cardiovascular and Hematological Disorders Drug Targets - July 3, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Antihyperglycemic potential of Matricaria pubescens(Desf.) Schultz. in streptozotocin-induced diabetic rats.
CONCLUSION: In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes. PMID: 32603288 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 2, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Vascular Effects of Avocado Seed Glycosides During Diabetes-induced Endothelial Damage.
CONCLUSION: The ASG had no relevant effect on glucose homeostasis during DIVD but showed significant vasoprotective properties. PMID: 32386502 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - May 12, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Hiv-Related Lymphoprolipherative Diseases In The Era Of Combination Antiretroviral Therapy.
Authors: Castelli R, Schiavon R, Preti C, Ferraris L Abstract HIV-positive patients have a 60- to 200-fold increased incidence of non-Hodgkin lymphomas (NHL) because of their impaired cellular immunity. Some NHL are considered acquired immunodeficiency syndrome (AIDS) defining conditions. Diffuse large B-cell Lymphoma (DLBC) and Burkitt lymphoma (BL) are the most commonly observed, whereas primary effusion lymphoma (PEL), Central Nervous System Lymphomas (PCNSL), plasmablastic lymphoma (PBL) and classic Hodgkin lymphoma (HL) are far less frequent. Multicentric Castleman disease (MCD) is an aggressive lymphoprolifer...
Source: Cardiovascular and Hematological Disorders Drug Targets - April 17, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Complications of muscle hematomas in hemophilia.
Authors: Rodriguez-Merchan EC Abstract Prevention is essential for avoiding the complications of muscle hematomas (compartment syndrome, pseudotumous and peripheral nerve lesions) in hemophilic patients. This is achieved through early diagnosis of muscle hematomas and proper long-term hematological treatment until they have resolved (confirmed by image studies). Ultrasound-guided percutaneous drainage could be beneficial in terms of achieving better and faster symptom relief. Acute compartment syndrome (ACS) requires emergency surgical treatment (decompression fasciotomy). As for pseudotumor, biopsy will help us co...
Source: Cardiovascular and Hematological Disorders Drug Targets - April 17, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Toxicity Evaluation of the Subacute Diazinon in Aged Male Rats: Hematological Aspects.
CONCLUSION: The present study showed that toxicity of DZN is not associated to age. However, more studies should be done to confirm this finding. PMID: 32133967 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 7, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

'do not do' recommendations in hemophilia.
CONCLUSIONS: The information mentioned previously can be useful in the management of hemophilia, from different levels of care. As far as we know, this is the first initiative of this type in hemophilia. PMID: 32133968 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 7, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Efficacy of Cangrelor as bridging therapy post PCI.
We present a case of 77-year old male on triple therapy (aspirin, apixaban, and ticagrelor) given history of paroxysmal atrial fibrillation and PCI of in-stent restenosis in an ostial RCA with a drug eluting stent one week prior for NSTEMI who presented with acute GI bleed. Apixaban was held and he was diagnosed with stage I colonic adenocarcinoma with immediate surgical resection recommended. Ticagrelor was discontinued 6 days prior to surgery and Cangrelor was started 24 hours after Ticagrelor discontinuation. Daily P2Y12 assays were performed to ensure adequate platelet inhibition and minimize bleeding risk. Cangrelor w...
Source: Cardiovascular and Hematological Disorders Drug Targets - March 1, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Stroke following successful PTMC in a patient with severe mitral stenosis: A case report and presenting a simple stepwise approach to PTMC-related stroke.
We present a middle-aged woman who experienced stroke following PTMC and successfully treated with thrombolytic therapy regarding the potential adverse effects of this type of therapy. Also, we present a simple novel stepwise clinical approach for PTMC-related stroke. PMID: 32077834 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - February 22, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Assessment of admission time cell blood count (CBC) parameters in predicting post- primary percutaneous coronary intervention TIMI frame count in patients with ST-segment elevation myocardial infarction.
In this study we aimed to assess the value of admission time CBC parameters in predicting post-primary PCI corrected TIMI frame count. BACKGROUND: Recent years have witnessed large series of studies evaluating different laboratory variables to predict no-reflow phenomenon following primary PCI (PPCI) in patients with STEMI. However, a general agreement about the most reliable predictor of no reflow phenomenon is challenging and also intriguing. METHODS: The current study concluded 208 consecutive patients who underwent primary PCI for ST-Elevation Myocardial Infarction (STEMI) from January 2014 to February 2016. Bl...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 7, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Co-existence of follicular lymphoma in the lymph node with High-grade B cell lymphoma in the bone marrow of a patient presenting with spontaneous tumor lysis syndrome.
Authors: Giatra C, Sykaras AG, Constantinou F, Gennimata V, Sampaziotis D, Geladari E, Kounatidis D, Vallianou NG Abstract A significant percentage of B-cell lymphomas are characterized by bone marrow involvement (BMI) at diagnosis. In most cases, there is concordance between the type of lymphoma present in the lymph node and the lymphoma present in the bone marrow. Herein, we present a sixty-seven years old female patient, who was diagnosed with High-Grade B-cell Lymphoma (HGBL) in the bone marrow, while simultaneously, in the peripheral lymph node, the presence of Follicular Lymphoma (FL) was noted. The patient p...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 2, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Effects of Simvastatin on the Metabolism of Fatty Acids in Combined Secondary Prevention of Coronary Heart Disease: Dosage and Gender Differences between the Effects.
CONCLUSIONS: Considering the formation of saturated fatty acids, statin performed better in males. With Omega-3 polyunsaturated fatty acids involved, changes in lipoproteins, cholesterol and fatty acids (liver and myocardium) were similar to those caused by small doses of a statin drug. Effects from the combination of bisoprolol and acetylsalicylic acid were completely different from those caused by the use of statin. PMID: 31916523 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - January 10, 2020 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Total Ankle Replacement in Hemophilia.
CONCLUSION: Whereas People With Advanced Hemophilic Arthropathy Of The Ankle Are Prone To Ameliorate Pain And Range Of Motion Following Tar, There Is Deficient Knowledge To Regularly Recommend Its Use. Adverse Events And Infection Percentages Are Disturbing. Moreover, The Lack Of Survival Analysis Knowledge Makes It Difficult To Assess The Benefit To People With Hemophilia. Tar Is A Demanding Surgical Procedure And Its Survival Is Not Comparable To That After Hip Or Knee Arthroplasty. PMID: 31820705 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - December 11, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats.
Authors: Kamkar-Del Y, Mohebbati R, Hoseini M, KhajaviRad A, Shafei MN, Rakhshande H Abstract BACKGROUND: Antihypertensive effect of Ziziphus jujube (ZJ) has been reported previously. OBJECTIVE: The present study investigates the effect of two ethyl acetate (polar and semi-polar compound) and aqueous fractions (polar compound) of ZJ on cardiovascular parameters in acute hypertension induced by angiotensin II(AngII). METHODS: Rats randomly were divided into as following groups (n=7 in each group): Control, AngII (50 ng/kg), Losartan (Los, 30 mg/kg) + AngII, ethyl acetate fraction (EA150 and EA300 mg/kg) + An...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 21, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Coexistence of Hodgkin and Non-Hodgkin lymphoma; Composite Lymphoma (CL) in a patient presenting with waxing and waning lymphadenopathy.
Conclusion: Composite lymphomas pose a particular diagnostic challenge, and currently there are no agreed standards for treatment (4). PMID: 31633478 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - October 22, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.
CONCLUSION: The results shows curcumin has not a significant effect on cathepsin D level in patients with MetS. PMID: 31538907 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 22, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Red Blood Cells are appropriate carrier for coagulation factor VIII.
CONCLUSION: This study aims to introduce erythrocytes as appropriate carriers for FVIII to prolong the dosing intervals in the effective and safe levels for a relatively longer time. PMID: 31533604 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 21, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF- α during high-intensity resistance training in low activity men.
Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-α during high-intensity resistance training in low activity men. Cardiovasc Hematol Disord Drug Targets. 2019 Sep 18;: Authors: Asghari E, Rashidlamir A, Hosseini SRA, Moazzami M, Samarghandian S, Farkhondeh T Abstract BACKGROUND: Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid which extracted from plants. UA may enhance the effect of resistance training (RT) in human. OBJECTIVE: Current research was designed to show the effect of high-intensity resistance training (HIR...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 21, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Prognostic Value of Cardiac Biomarkers Assessment in Combination with Myocardial 2D Strain Echocardiography for Early Detection of Anthracycline-Related Cardiac Toxicity.
CONCLUSION: This study has shown that hs-cTnI with good sensitivity can predict cardiac toxicity in Anthracycline-based chemotherapy receiver. Use of strain with speckle echocardiography method has prognostic value; however, both longitudinal and segmental strain should be assessed. Lateral and inferoseptal SLS (segmental longitudinal strain) are specific markers of cardiac toxicity in the course of anthracycline-related cardiac toxicity. PMID: 31513000 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 14, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Protective Effects of TRPV1 Activation Against Cardiac Ischemia/Reperfusion Injury Is Blunted by Diet-Induced Obesity.
Authors: Zhong B, Ma S, Wang DH Abstract BACKGROUND: Activation of transient receptor potential vanilloid subtype 1 (TRPV1) channels protects the heart from ischemia/reperfusion (I/R) injury through releasing calcitonin gene-related peptide (CGRP) and substance P (SP). The current study aimed to study the cardioprotective effects of TRPV1 in obesity. METHODS: TRPV1 gene knockout (TRPV1-/-) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet or for 20 weeks, and then the hearts were collected for I/R injury ex vivo. The hearts were mounted on a Langendorff apparatus and subjected to ischemia...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 14, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Effect of Terebinthus atlanticus on glucose metabolism in diabetic rats.
Authors: El-Ouady F, Eddouks M Abstract BACKGROUND: Pistachia atlantica Desf, (Anacardiaceae) is an important source of essential oil and phenolic compounds justifying the use of its various parts in traditional medicine. OBJECTIVE: The present work aimed to evaluate the antidiabetic and the antioxidant activities of the aqueous extract of the leaves of Pistachia atlantica. METHODS: The current study evaluated the effect of a single and repeated (15 days of treatment) oral administration of the aqueous extract of the leaves of Pistachia atlantica (PALAE) on blood glucose levels in normal and streptozotocin(...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 4, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Impact of Leukemia Stem Cells Phenotype Expression on Response to Induction Therapy in Acute Myeloid Leukemia Patients.
CONCLUSIONS: 1. LSCs were expressed in 63.41% of AML cases and were distributed among FAB subtypes without preference to any FAB subtype. 2. The expression of LSC phenotype was associated with poor response to induction therapy in AML patients. PMID: 31438833 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 25, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Factors which influence the levels of ST-2, Galectin-3 and MMP-9 in Acute Coronary Syndrome.
CONCLUSION: High Galectin-3, MMP-9, and ST-2 are independently influenced to a certain degree by demographic, clinical and laboratory characteristics. However, no single characteristic was found to be commonly associated with all of the three biomarkers. PMID: 31438834 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 25, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

CD123 a novel biomaker for diagnosis and treatment of leukemia.
Authors: Shi M, Jeanna Su R, Parmar KP, Chaudhry R, Sun K, Rao J, Chen M Abstract Leukemia is a group of progressive hematologic malignancies derived from hematopoietic stem cells (HSCs) in bone marrow which causes a large number of cancer deaths. Even with treatment such as traditional chemotherapy, targeted therapy, and allogeneic stem cell transplantation (allo-HSCT), the majority of patients in the end relapse with drug-resistance and the overall survival is dismal. Leukemic stem cells (LSCs) take responsibility for the evolution, relapse and drug-resistance of leukemia. Emerging studies demonstrate that CD123,...
Source: Cardiovascular and Hematological Disorders Drug Targets - June 29, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

The effects of chrysin on serum corticosterone levels and brain oxidative injury induced by immobilization in rat.
Authors: Farkhondeh T, Jalali S, Samarghandian S, Samini F Abstract The current study was designed to investigate the effects of chrysin (CH) on serum corticosterone level. We also investigated depression-like behavior induced by chronic restraint stress in rats. The rats were kept in restrainers for 1 hour daily for 21 consecutive days. Then, the animals were daily injected with either vehicle or CH (10, 20, 30 µg/kg) for 21 days. Our findings showed that the serum corticosterone levels significantly increased in rats submitted to the restraint stress versus non-stressed animals (p
Source: Cardiovascular and Hematological Disorders Drug Targets - June 27, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Bivalirudin versus Heparin during intervention in Acute Coronary Syndrome: A Systematic Review of Randomized Trials.
CONCLUSION: Bivalirudin demonstrates its superiority over heparin plus GPI with better clinical outcomes in terms of preventing bleeding complications, thus making it as an anticoagulation of choice particularly in patients at high risk of bleeding. Further studies are warranted for head to head comparison of bivalirudin to heparin monotherapy to establish an optimal heparin dosing regimen and post-PCI bivalirudin infusion to affirm its beneficial effect in reducing acute ST. PMID: 31241442 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - June 27, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Antihyperglycemic effect of the aqueous extract of Foeniculum vulgare in normal and streptozotocin-induced diabetic rats.
The objective of the study was to investigate the antidiabetic and antioxidant effects of Foeniculum vulgare in streptozotocin-induced diabetic rat. METHODS: The effects of the leaves aqueous extract (LAE) of Foeniculum vulgare (F. vulgare) at a dose of 10 mg/kg on blood glucose levels were evaluated in normal and streptozotocin (STZ)-induced diabetic rats. Histopathological changes were also evaluated in liver in STZ-induced rats. RESULTS: Single oral administration of F. vulgare LAE reduced blood glucose levels 6 h after administration in STZ diabetic rats (p
Source: Cardiovascular and Hematological Disorders Drug Targets - June 16, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

The effect of stenotic geometry and non-Newtonian property of blood flow through arterial stenosis.
Authors: Sriyab S Abstract A mathematical model of non-Newtonian blood flow through different stenosis, namely bell shape and cosine shape, are considered. The non-Newtonian model is characterized by Power-law model. We obtain physiologically important flow quantities of blood flow behavior such as resistance to flow, skin friction and blood flow rate. We find that the cosine geometry exhibits higher resistance to flow, flow rate, and lower skin friction than the bell geometry. We not only study the effect of stenotic geometry but also study the effect of stenosis depth and stenosis height on the flow quantities. M...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 11, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Neutrophil gelatinase-associated lipocalin as a marker of postoperative acute kidney injury following cardiac surgery in patients with pre-operative kidney impairment.
Authors: Tidbury N, Browning N, Shaw M, Morgan M, Kemp I, Matata B Abstract INTRODUCTION: Acute kidney injury (AKI) is a serious complication of cardiac surgery. The current 'gold standard' for determining AKI is change in serum creatinine and urine output, however, this change occurs relatively late after actual injury occurs. Identification of new biomarkers that detect early AKI is required. Recently new biomarkers, such as the NephroCheck® Test and AKIRisk have also been tested and found to be good indicators of AKI. Neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in paediatric patients ...
Source: Cardiovascular and Hematological Disorders Drug Targets - April 18, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

P wave dispersion and silent atrial fibrillation in cryptogenic stroke: the pathogenic role of inflammation.
CONCLUSIONS: In cryptogenic stroke, high PWD is partly due to systemic inflammation that increases AF risk possibly via atrial electric remodeling. These findings could also suggest inflammation as a possible therapeutic target in order to prevent atrial electrical alterations and finally AF occurrence in CS. PMID: 30968778 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - April 11, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Preface.
Authors: Shen G Abstract PMID: 30854947 [PubMed - in process] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 12, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Recent Advancements in Identification of Novel Drug Targets and Drug Delivery for Cardiovascular and Hematological Disorders.
Authors: Mittal R, Jayant RD Abstract PMID: 30854948 [PubMed - in process] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 12, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Thrombotic events in homozygotes with a proven or highly probable Arg304Gln Factor VII mutation (FVII Padua) 1): only limited replacement therapy is needed in case of surgery.
CONCLUSIONS: proven homozygous or compound heterozygous patients with the Arg304Gln mutation showed a higher than expected incidence of thrombotic events. The same is true for probable cases gathered only on the basis of clotting tests. These patients, because of their frequent lack of bleeding and for their relatively high prevalence of thrombosis should probably receive only limited replacement therapy in case of surgical procedures. PMID: 30854979 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 12, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

An HHV-8 Positive HIV Negative Multicentric Castleman's Disease, Who Responded Well to Rituximab Alone.
Authors: Kounatidis D, Rontogianni D, Sampaziotis D, Vardaka M, Giatra C, Dolapsakis C, Margellou E, Vallianou NG Abstract Multicentric Castleman Disease (MCD) presents with enlarged lymph nodes in multiple regions and systemic inflammatory symptoms, due to the dysregulation of cytokines, most commonly interleukin-6 (IL-6). Human herpes virus-8 (HHV-8) is strongly related to MCD (HHV-8-associated MCD) and is being implicated in cytokine dysregulation in patients, the majority of whom are HIV positive or immunosuppressed. Preferred treatment of HHV-8-associated MCD depends on the presence or not of concurrent Kaposi...
Source: Cardiovascular and Hematological Disorders Drug Targets - March 5, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Glucose lowering activity of aqueous Ammodaucus leucotrichus extract in diabetic rats.
In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of A. Leucotrichus in rats supporting then its traditional use for the management of diabetes. PMID: 30806327 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - February 28, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Impact of the Fontan operation on organ systems.
Authors: Michel M, Zlamy M, Entenmann A, Pichler K, Scholl-Bürgi S, Karall D, Geiger R, Salvador C, Niederwanger C, Ohuchi H Abstract In patients having undergone the Fontan operation, besides the well discussed changes in the cardiac, pulmonary and gastrointestinal system, alterations of further organ systems including the hematologic, immunologic, endocrinological and metabolic are reported. As a medical adjunct to Fontan surgery, the systematic study of the central role of the liver as a metabolizing and synthesizing organ should allow for a better understanding of the pathomechanism underlying the typical ...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 13, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Relationship Between level of heart type Fatty Acid binding protein (Before and After Procedures) with Acute Renal Failure after PCI in Patients under PCI.
Authors: Mohammadzadeh M, Haybar H, Assare AR, Zayeri ZD, Hoveyzian SA Abstract BACKGROUND & OBJECTIVE: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors with a focus on (HFAB-P) that can be predictive for AKI after Percutaneous Coronary Intervention (PCI). METHODS: This prospective study was performed on 95 patients (55 males and 44 females aged between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz. Patients were ...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A.
CONCLUSION: It seems that TNFα rs1800629 G> A polymorphism decreased the risk of inhibitor formation in Iranian patients with HA. PMID: 30727925 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Genetics Of Atrial Fibrilation: In Search Of Novel Therapeutic Targets.
Authors: Lozano-Velasco E, Garcia-Padilla C, Aránega AE, Franco D Abstract Atrial fibrillation (AF) is the most frequent arrhythmogenic disease in humans, ranging from 2% in the general population and raising up to 10-12% in 80+ years. Genetic analyses of AF familiar cases have identified a series of point mutations in distinct ion channels, supporting a causative link. However, these genetic defects only explain a minority of AF patients. Genome-wide association studies identified single nucleotide polymorphisms (SNPs), close to PITX2 on 4q25 chromosome, that are highly associated to AF. Subsequent GWAS stu...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Comprehensive Review on Diabetes Associated Cardiovascular Complications - The Vitamin D Perspective.
Authors: Y D, Manjrekar PA, Adhikari P, M C, Ms R Abstract Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs). A dependent link was propos...
Source: Cardiovascular and Hematological Disorders Drug Targets - January 17, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Factor X deficiency due to a compound heterozygosis between a new mutation (Gla72Asp) in exon 2 and an already known one (Gly154Arg) in exon 5: Factor X Mar del Plata 1).
Authors: Girolami A, de Paoletti DNG, Nenkies ML, Ferrari S, Guglielmone H Abstract A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. The mother was asymptomatic but was a heterozygote for the new mutation. The father was asymptomatic but had deserted the family and could not be investigated. After this abandonme...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 14, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Diagnostic Value of HLA Typing in Pathogenesis of Cardiomyopathy.
Authors: Haybar H, Shahrabi S, Shahjahani M, Rezaeeyan H Abstract Development of cardiomyopathy (CM) is dependent upon several factors. However, reaction of immune response against myocardial tissue due to microbial and viral infections plays an important role in this disease. Therefore, the purpose of this study is to investigate the relationship between HLAs and their pathogenic mechanisms in the incidence of CM. Relevant literature was identified by a PubMed search (1989-2017) of English-language papers using the terms "Cardiomyopathy", "Human leukocyte antigen or HLA", "immune response&...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 8, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Carfilzomib: a Tale of a Heartbreaking Moment. Case Report and Concise Review of the Literature.
Authors: Serra W, Fantin A, Longo C, Rabia G, De Rosa F, Plenteda C, Re F, Crisafulli E, Chetta A Abstract Carfilzomib, a proteasome inhibitor, known as a therapeutical option for people who have already received one or more previous treatments for multiple myeloma, has well known cardiac and systemic adverse effects. There is evidence supporting that adverse effects are dose-dependent, yet there is no known patient phenotype characterized by worse associated consequences, nor are there widely accepted monitoring protocols. In this article we describe two patients with cardiovascular adverse events related to carfi...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 7, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Pentraxin level is the key to determine primary Percutaneous Coronary Intervention (PCI) or fibrinolysis.
Authors: Haybar H, Parsa SA, Khaheshi I, Zayeri ZD Abstract AIM: To examine if pentraxin can help identifying patients benefitting most from primary Percutaneous Coronary Intervention (PCI) vs. fibrinolysis. METHODS: Patients with acute ST-Elevation Myocardial Infarction (STEMI) were consecutively recruited from a community center without PCI and a tertiary center with PCI facilities.Left ventricular ejection fraction (LVEF) was determined echocardiographically at baseline and 5 day after the index admission; the difference between two measurements was considered as the magnitude of improvement. We used regress...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 24, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research