Coexistence of Hodgkin and Non-Hodgkin lymphoma; Composite Lymphoma (CL) in a patient presenting with waxing and waning lymphadenopathy.
Conclusion: Composite lymphomas pose a particular diagnostic challenge, and currently there are no agreed standards for treatment (4). PMID: 31633478 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - October 22, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.
CONCLUSION: The results shows curcumin has not a significant effect on cathepsin D level in patients with MetS. PMID: 31538907 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 22, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Red Blood Cells are appropriate carrier for coagulation factor VIII.
CONCLUSION: This study aims to introduce erythrocytes as appropriate carriers for FVIII to prolong the dosing intervals in the effective and safe levels for a relatively longer time. PMID: 31533604 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 21, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF- α during high-intensity resistance training in low activity men.
Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-α during high-intensity resistance training in low activity men. Cardiovasc Hematol Disord Drug Targets. 2019 Sep 18;: Authors: Asghari E, Rashidlamir A, Hosseini SRA, Moazzami M, Samarghandian S, Farkhondeh T Abstract BACKGROUND: Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid which extracted from plants. UA may enhance the effect of resistance training (RT) in human. OBJECTIVE: Current research was designed to show the effect of high-intensity resistance training (HIR...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 21, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Prognostic Value of Cardiac Biomarkers Assessment in Combination with Myocardial 2D Strain Echocardiography for Early Detection of Anthracycline-Related Cardiac Toxicity.
CONCLUSION: This study has shown that hs-cTnI with good sensitivity can predict cardiac toxicity in Anthracycline-based chemotherapy receiver. Use of strain with speckle echocardiography method has prognostic value; however, both longitudinal and segmental strain should be assessed. Lateral and inferoseptal SLS (segmental longitudinal strain) are specific markers of cardiac toxicity in the course of anthracycline-related cardiac toxicity. PMID: 31513000 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 14, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Protective Effects of TRPV1 Activation Against Cardiac Ischemia/Reperfusion Injury Is Blunted by Diet-Induced Obesity.
Authors: Zhong B, Ma S, Wang DH Abstract BACKGROUND: Activation of transient receptor potential vanilloid subtype 1 (TRPV1) channels protects the heart from ischemia/reperfusion (I/R) injury through releasing calcitonin gene-related peptide (CGRP) and substance P (SP). The current study aimed to study the cardioprotective effects of TRPV1 in obesity. METHODS: TRPV1 gene knockout (TRPV1-/-) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet or for 20 weeks, and then the hearts were collected for I/R injury ex vivo. The hearts were mounted on a Langendorff apparatus and subjected to ischemia...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 14, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Effect of Terebinthus atlanticus on glucose metabolism in diabetic rats.
Authors: El-Ouady F, Eddouks M Abstract BACKGROUND: Pistachia atlantica Desf, (Anacardiaceae) is an important source of essential oil and phenolic compounds justifying the use of its various parts in traditional medicine. OBJECTIVE: The present work aimed to evaluate the antidiabetic and the antioxidant activities of the aqueous extract of the leaves of Pistachia atlantica. METHODS: The current study evaluated the effect of a single and repeated (15 days of treatment) oral administration of the aqueous extract of the leaves of Pistachia atlantica (PALAE) on blood glucose levels in normal and streptozotocin(...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 4, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Impact of Leukemia Stem Cells Phenotype Expression on Response to Induction Therapy in Acute Myeloid Leukemia Patients.
CONCLUSIONS: 1. LSCs were expressed in 63.41% of AML cases and were distributed among FAB subtypes without preference to any FAB subtype. 2. The expression of LSC phenotype was associated with poor response to induction therapy in AML patients. PMID: 31438833 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 25, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Factors which influence the levels of ST-2, Galectin-3 and MMP-9 in Acute Coronary Syndrome.
CONCLUSION: High Galectin-3, MMP-9, and ST-2 are independently influenced to a certain degree by demographic, clinical and laboratory characteristics. However, no single characteristic was found to be commonly associated with all of the three biomarkers. PMID: 31438834 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 25, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

CD123 a novel biomaker for diagnosis and treatment of leukemia.
Authors: Shi M, Jeanna Su R, Parmar KP, Chaudhry R, Sun K, Rao J, Chen M Abstract Leukemia is a group of progressive hematologic malignancies derived from hematopoietic stem cells (HSCs) in bone marrow which causes a large number of cancer deaths. Even with treatment such as traditional chemotherapy, targeted therapy, and allogeneic stem cell transplantation (allo-HSCT), the majority of patients in the end relapse with drug-resistance and the overall survival is dismal. Leukemic stem cells (LSCs) take responsibility for the evolution, relapse and drug-resistance of leukemia. Emerging studies demonstrate that CD123,...
Source: Cardiovascular and Hematological Disorders Drug Targets - June 29, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

The effects of chrysin on serum corticosterone levels and brain oxidative injury induced by immobilization in rat.
Authors: Farkhondeh T, Jalali S, Samarghandian S, Samini F Abstract The current study was designed to investigate the effects of chrysin (CH) on serum corticosterone level. We also investigated depression-like behavior induced by chronic restraint stress in rats. The rats were kept in restrainers for 1 hour daily for 21 consecutive days. Then, the animals were daily injected with either vehicle or CH (10, 20, 30 µg/kg) for 21 days. Our findings showed that the serum corticosterone levels significantly increased in rats submitted to the restraint stress versus non-stressed animals (p
Source: Cardiovascular and Hematological Disorders Drug Targets - June 27, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Bivalirudin versus Heparin during intervention in Acute Coronary Syndrome: A Systematic Review of Randomized Trials.
CONCLUSION: Bivalirudin demonstrates its superiority over heparin plus GPI with better clinical outcomes in terms of preventing bleeding complications, thus making it as an anticoagulation of choice particularly in patients at high risk of bleeding. Further studies are warranted for head to head comparison of bivalirudin to heparin monotherapy to establish an optimal heparin dosing regimen and post-PCI bivalirudin infusion to affirm its beneficial effect in reducing acute ST. PMID: 31241442 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - June 27, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Antihyperglycemic effect of the aqueous extract of Foeniculum vulgare in normal and streptozotocin-induced diabetic rats.
The objective of the study was to investigate the antidiabetic and antioxidant effects of Foeniculum vulgare in streptozotocin-induced diabetic rat. METHODS: The effects of the leaves aqueous extract (LAE) of Foeniculum vulgare (F. vulgare) at a dose of 10 mg/kg on blood glucose levels were evaluated in normal and streptozotocin (STZ)-induced diabetic rats. Histopathological changes were also evaluated in liver in STZ-induced rats. RESULTS: Single oral administration of F. vulgare LAE reduced blood glucose levels 6 h after administration in STZ diabetic rats (p
Source: Cardiovascular and Hematological Disorders Drug Targets - June 16, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

The effect of stenotic geometry and non-Newtonian property of blood flow through arterial stenosis.
Authors: Sriyab S Abstract A mathematical model of non-Newtonian blood flow through different stenosis, namely bell shape and cosine shape, are considered. The non-Newtonian model is characterized by Power-law model. We obtain physiologically important flow quantities of blood flow behavior such as resistance to flow, skin friction and blood flow rate. We find that the cosine geometry exhibits higher resistance to flow, flow rate, and lower skin friction than the bell geometry. We not only study the effect of stenotic geometry but also study the effect of stenosis depth and stenosis height on the flow quantities. M...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 11, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Neutrophil gelatinase-associated lipocalin as a marker of postoperative acute kidney injury following cardiac surgery in patients with pre-operative kidney impairment.
Authors: Tidbury N, Browning N, Shaw M, Morgan M, Kemp I, Matata B Abstract INTRODUCTION: Acute kidney injury (AKI) is a serious complication of cardiac surgery. The current 'gold standard' for determining AKI is change in serum creatinine and urine output, however, this change occurs relatively late after actual injury occurs. Identification of new biomarkers that detect early AKI is required. Recently new biomarkers, such as the NephroCheck® Test and AKIRisk have also been tested and found to be good indicators of AKI. Neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in paediatric patients ...
Source: Cardiovascular and Hematological Disorders Drug Targets - April 18, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

P wave dispersion and silent atrial fibrillation in cryptogenic stroke: the pathogenic role of inflammation.
CONCLUSIONS: In cryptogenic stroke, high PWD is partly due to systemic inflammation that increases AF risk possibly via atrial electric remodeling. These findings could also suggest inflammation as a possible therapeutic target in order to prevent atrial electrical alterations and finally AF occurrence in CS. PMID: 30968778 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - April 11, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Preface.
Authors: Shen G Abstract PMID: 30854947 [PubMed - in process] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 12, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Recent Advancements in Identification of Novel Drug Targets and Drug Delivery for Cardiovascular and Hematological Disorders.
Authors: Mittal R, Jayant RD Abstract PMID: 30854948 [PubMed - in process] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 12, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Thrombotic events in homozygotes with a proven or highly probable Arg304Gln Factor VII mutation (FVII Padua) 1): only limited replacement therapy is needed in case of surgery.
CONCLUSIONS: proven homozygous or compound heterozygous patients with the Arg304Gln mutation showed a higher than expected incidence of thrombotic events. The same is true for probable cases gathered only on the basis of clotting tests. These patients, because of their frequent lack of bleeding and for their relatively high prevalence of thrombosis should probably receive only limited replacement therapy in case of surgical procedures. PMID: 30854979 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - March 12, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

An HHV-8 Positive HIV Negative Multicentric Castleman's Disease, Who Responded Well to Rituximab Alone.
Authors: Kounatidis D, Rontogianni D, Sampaziotis D, Vardaka M, Giatra C, Dolapsakis C, Margellou E, Vallianou NG Abstract Multicentric Castleman Disease (MCD) presents with enlarged lymph nodes in multiple regions and systemic inflammatory symptoms, due to the dysregulation of cytokines, most commonly interleukin-6 (IL-6). Human herpes virus-8 (HHV-8) is strongly related to MCD (HHV-8-associated MCD) and is being implicated in cytokine dysregulation in patients, the majority of whom are HIV positive or immunosuppressed. Preferred treatment of HHV-8-associated MCD depends on the presence or not of concurrent Kaposi...
Source: Cardiovascular and Hematological Disorders Drug Targets - March 5, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Glucose lowering activity of aqueous Ammodaucus leucotrichus extract in diabetic rats.
In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of A. Leucotrichus in rats supporting then its traditional use for the management of diabetes. PMID: 30806327 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - February 28, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Impact of the Fontan operation on organ systems.
Authors: Michel M, Zlamy M, Entenmann A, Pichler K, Scholl-Bürgi S, Karall D, Geiger R, Salvador C, Niederwanger C, Ohuchi H Abstract In patients having undergone the Fontan operation, besides the well discussed changes in the cardiac, pulmonary and gastrointestinal system, alterations of further organ systems including the hematologic, immunologic, endocrinological and metabolic are reported. As a medical adjunct to Fontan surgery, the systematic study of the central role of the liver as a metabolizing and synthesizing organ should allow for a better understanding of the pathomechanism underlying the typical ...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 14, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Relationship Between level of heart type Fatty Acid binding protein (Before and After Procedures) with Acute Renal Failure after PCI in Patients under PCI.
Authors: Mohammadzadeh M, Haybar H, Assare AR, Zayeri ZD, Hoveyzian SA Abstract BACKGROUND & OBJECTIVE: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors with a focus on (HFAB-P) that can be predictive for AKI after Percutaneous Coronary Intervention (PCI). METHODS: This prospective study was performed on 95 patients (55 males and 44 females aged between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz. Patients were ...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A.
CONCLUSION: It seems that TNFα rs1800629 G> A polymorphism decreased the risk of inhibitor formation in Iranian patients with HA. PMID: 30727925 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Genetics Of Atrial Fibrilation: In Search Of Novel Therapeutic Targets.
Authors: Lozano-Velasco E, Garcia-Padilla C, Aránega AE, Franco D Abstract Atrial fibrillation (AF) is the most frequent arrhythmogenic disease in humans, ranging from 2% in the general population and raising up to 10-12% in 80+ years. Genetic analyses of AF familiar cases have identified a series of point mutations in distinct ion channels, supporting a causative link. However, these genetic defects only explain a minority of AF patients. Genome-wide association studies identified single nucleotide polymorphisms (SNPs), close to PITX2 on 4q25 chromosome, that are highly associated to AF. Subsequent GWAS stu...
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Comprehensive Review on Diabetes Associated Cardiovascular Complications - The Vitamin D Perspective.
Authors: Y D, Manjrekar PA, Adhikari P, M C, Ms R Abstract Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs). A dependent link was propos...
Source: Cardiovascular and Hematological Disorders Drug Targets - January 17, 2019 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Factor X deficiency due to a compound heterozygosis between a new mutation (Gla72Asp) in exon 2 and an already known one (Gly154Arg) in exon 5: Factor X Mar del Plata 1).
Authors: Girolami A, de Paoletti DNG, Nenkies ML, Ferrari S, Guglielmone H Abstract A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. The mother was asymptomatic but was a heterozygote for the new mutation. The father was asymptomatic but had deserted the family and could not be investigated. After this abandonme...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 14, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Diagnostic Value of HLA Typing in Pathogenesis of Cardiomyopathy.
Authors: Haybar H, Shahrabi S, Shahjahani M, Rezaeeyan H Abstract Development of cardiomyopathy (CM) is dependent upon several factors. However, reaction of immune response against myocardial tissue due to microbial and viral infections plays an important role in this disease. Therefore, the purpose of this study is to investigate the relationship between HLAs and their pathogenic mechanisms in the incidence of CM. Relevant literature was identified by a PubMed search (1989-2017) of English-language papers using the terms "Cardiomyopathy", "Human leukocyte antigen or HLA", "immune response&...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 8, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Carfilzomib: a Tale of a Heartbreaking Moment. Case Report and Concise Review of the Literature.
Authors: Serra W, Fantin A, Longo C, Rabia G, De Rosa F, Plenteda C, Re F, Crisafulli E, Chetta A Abstract Carfilzomib, a proteasome inhibitor, known as a therapeutical option for people who have already received one or more previous treatments for multiple myeloma, has well known cardiac and systemic adverse effects. There is evidence supporting that adverse effects are dose-dependent, yet there is no known patient phenotype characterized by worse associated consequences, nor are there widely accepted monitoring protocols. In this article we describe two patients with cardiovascular adverse events related to carfi...
Source: Cardiovascular and Hematological Disorders Drug Targets - December 7, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Pentraxin level is the key to determine primary Percutaneous Coronary Intervention (PCI) or fibrinolysis.
Authors: Haybar H, Parsa SA, Khaheshi I, Zayeri ZD Abstract AIM: To examine if pentraxin can help identifying patients benefitting most from primary Percutaneous Coronary Intervention (PCI) vs. fibrinolysis. METHODS: Patients with acute ST-Elevation Myocardial Infarction (STEMI) were consecutively recruited from a community center without PCI and a tertiary center with PCI facilities.Left ventricular ejection fraction (LVEF) was determined echocardiographically at baseline and 5 day after the index admission; the difference between two measurements was considered as the magnitude of improvement. We used regress...
Source: Cardiovascular and Hematological Disorders Drug Targets - November 24, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

The effect of borage (Echium amoenum) on the mouse heart and hematology parameters.
CONCLUSION: This article was suggested that the borage did not make significant damages to heart tissue in mice model. In hematology factors significant changes was observed in erythrocytes and related parameters. Therefore, hematotoxicity of consumption this plant should be considered at high doses. PMID: 30394224 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - November 7, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Adenosine as a marker and mediator of cardiovascular homeostasis: a translational perspective.
Conclusion Herein, we provide a bench-to-bedside review of adenosine biology, highlighting the key considerations for further translational development of this promising molecule. PMID: 30318008 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - October 17, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Protective effects of curcumin against toxic agents-induced renal failure: a review.
Authors: Farkhondeh T, Samarghandian S, Azimi-Nezhad M, Shahri AMP Abstract Curcumin, is the major phenolic compound the rhizome of the Curcuma species that is used in herbal medicine. Several studies has showed the protective effects of curcumin against nephrotoxi agents such as gallic acid, glucose, tartrazine, streptozotocin, lead, maleate, malathion, nicotine, cisplatin, gentamicin and methotrexate. However, due to the lake of linical trial studies, more investigation are needed to determine the efficacy of curcumin as an antidote agent. The present study aimed to critically review the recent literature data fr...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 14, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Blood biomarkers for ischemic stroke subtype differentiation: A systematic review.
Conclusion Our systematic review does not recommend the use of any blood biomarker for clinical purposes based on the studies conducted till date. BNP and D-dimer may present optimal biomarker for diagnosis and differentiation of ischemic stroke. However, large well-designed clinical studies are required to validate utility of these biomarkers to differentiate subtypes of ischemic stroke. PMID: 30160220 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - September 1, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Pure red cell aplasia caused by azathioprine: case report and review of the literature.
Authors: Kounatidis D, Vallianou N, Daskalaki V, Masaoutis C, Margellou E, Harhalakis N, Kokkinakis E Abstract Pure red cell aplasia (PRCA) is a clinical entity comprising severe normochromic normocytic anemia, reticulocytopenia, erythroblastopenia in the bone marrow, with normal leukocyte and platelets count. PRCA can be classified into congenital and acquired, with the latter characterized as idiopathic or secondary to various infections, hematological malignancies, collagen vascular diseases, thymoma, and exposure to a variety of drugs and other chemical substances. Herein, we present a female patient, who prese...
Source: Cardiovascular and Hematological Disorders Drug Targets - August 31, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

In situ oxidative stress and atrial cell deaths in patients with valve disease.
CONCLUSIONS: The findings suggests that oxidative stress originating from in situ leukocytes within the atrial myocardium may be the potential trigger for excessive transcriptional activities and apoptotic cell death within the atrial myocardium of valve disease patients. This represents a potential therapeutic target. PMID: 30033881 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 25, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Sodium-glucose Co-transporters 2 Inhibitors: The Miraculous Route from Hypoglycemic to Cardiovascular Drugs.
Authors: Imprialos KP, Stavropoulos K, Doumas M PMID: 30009694 [PubMed - in process] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - July 18, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Cardiovascular Effects Mediated by Imidazoline Drugs: an Update.
Authors: Cobos-Puc LE, Aguayo-Morales H Abstract Clonidine is a centrally acting antihypertensive drug. Hypotensive effect of clonidine is mediated mainly by central a2-adrenoceptors and/or imidazoline receptors located in a complex network of the brainstem. Unfortunately, clonidine produces side effects such as sedation, mouth dry, and depression. Moxonidine and rilmenidine, compounds of the second generation of imidazoline drugs, with fewer side effects, display a higher affinity for the imidazoline receptors compared with a2-adrenoceptors. The antihypertensive action of these drugs is due to inhibition of the sy...
Source: Cardiovascular and Hematological Disorders Drug Targets - July 3, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Pseudomonas aeruginosa invades human aortic endothelial cells and induces cell damage in vitro.
CONCLUSIONS: In this study, we demonstrate for first time that P. aeruginosa can invade and survive inside HAECs. This cell culture model can be of immense importance to determine the efficacy of drug targets against IE. PMID: 29886837 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - June 13, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Editorial: Growing Researches Responding to the Booming of Cardiovascular and Metabolic Diseases in China and Canada.
Authors: Shen GX PMID: 29804526 [PubMed - in process] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - May 30, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Treatment of Lymphoid and Myeloid Malignancies by Immunomodulatory Drugs.
Authors: Fuchs O PMID: 29788898 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - May 24, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

High Altitude Pulmonary Hypertension.
Authors: Bussotti M, Marchese G Abstract The effects of hypoxia on the human organism has been considered doubly fascinating by the scientific community: the knowledge of the discrete mechanisms allowing the acclimatization both at the genetic level or through the cell mediators production in addition to the macroscopic responses of the cardio-circulatory and ventilatory systems to a hypoxic environment has been progressively developed since the last century; moreover granting a safer stay in hypoxic conditions not only for the residents but also for the different cathegories of workers, sportsmen and tourists has ...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 20, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Humoral immunity in heart failure.
Authors: Rafiq K Abstract Cardiovascular disease (CVD) is a class of diseases that involve disorders of heart and blood vessels, including: hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, which finally lead to heart failure (HF). There are several treatments available all over the world, but still CVD and heart failure became the number one problem causing death every year worldwide. Both experimental and clinical studies have shown a role for inflammation in the pathogenesis of heart failure. This seems related to an imbalance between pro-inflammatory and anti-inflammato...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 20, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Acute Myeloid Leukemia: Diagnosis and Management Based On Current Molecular Genetics Approach.
CONCLUSION: AML is genetically and functionally a heterogenous malignant disease. In the western world leukemia is one of the most common among all cancers. India is ranked 3rd in cancer disease after United State (US) and China. Cytogenetic analysis and molecular prognostic biomarkers help in determining prognosis of the disease. Moreover, molecular biomarkers will also be helpful in redefining treatment strategies. A number of targeted drugs in pre-clinical and clinical trials have been reported to have promising results in AML patients. Recent studies have stated that not only cytogenetics and molecular genetics but als...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 17, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Irisin in coronary bypass surgery.
Authors: Aydin S, Catak Z, Eren MN, Aydin S, Topal AE Abstract INTRODUCTION: In coronary bypass surgery, after cardiopulmonary bypass is initiated by arterial cannulation in the ascending aorta and venous cannulation through a single vein generally in the right atrium, the process of cooling the patient is started. There is a relation between cooling the patient and irisin, which is responsible for releasing heat. OBJECTIVE: Therefore, the main objective of the present study is to explore how irisin concentrations and some other panel of myocardium injury in patients undergoing coronary artery bypass surgery ch...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 13, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Nanoparticle based treatment for Cardiovascular Diseases.
Authors: Jayant RD, Gupta P, Garcia E, Sarkar A, Kapoor S, Rafiq K, Chand HS, Nair M Abstract Nanotechnology has gained increased attention for delivering therapeutic agents effectively to the cardiovascular system. Heart targeted nanocarrier based drug delivery is a new, effective and efficacious approach for treating various cardiac related disorders such as atherosclerosis, hypertension, and myocardial infarction . Nanocarrier based drug delivery system circumvents the problems associated with conventional drug delivery systems, including their non-specificity, severe side effects and damage to the normal cells....
Source: Cardiovascular and Hematological Disorders Drug Targets - May 10, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Recent advances in understanding the pathogenesis of cardiovascular diseases and development of treatment modalities.
The objective of this article is to review the pathogenesis of atherosclerosis, first-line medical treatment for CVD, and key obstacles in efficient drug delivery. PMID: 29737266 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - May 10, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Role of AMPK in Diabetic Cardiovascular Complications: An Overview.
Authors: Kumar A, Nellaiappan K, Yerra VG Abstract Macrovascular complications of diabetes like cardiovascular diseases appear to be one of the leading causes of mortality. Current therapies aimed at counteracting the adverse effects of diabetes on cardiovascular system are found to be inadequate. Hence, there is growing need in search of novel targets. Adenosine monophosphate activated protein kinase (AMPK) is one such promising target, as a plethora of evidences point to its cardioprotective role in pathological milieu like cardiac hypertrophy, atherosclerosis and heart failure. AMPK is a serine-threonine kinase,...
Source: Cardiovascular and Hematological Disorders Drug Targets - May 10, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Knockout of TRPV1 Exacerbates Left Ventricular Diastolic Dysfunction Induced by A High-fat Diet in Mice.
CONCLUSION: In summary, TRPV1 knockout exacerbates HFD-induced glucose intolerance, cardiac oxidative stress and collagen deposition, leading to aggravated LV diastolic dysfunction. PMID: 29732984 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - May 9, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Treatment of Chronic Articular Pain in Adults with Hemophilia.
CONCLUSION: Most adult PWH experience limitations in activities of daily living, and chronic articular pain affects their mental health. Pharmacologic treatment of pain in adult PWH has frequently proven to be inadequate. The optimal pharmacologic treatment of chronic articular pain in these patients is the use of paracetamol and COX-2 inhibitors. Physical medicine, rehabilitation and intra-articular injections of hyaluronic acid and corticosteroids should be second-line therapy. PMID: 29732985 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - May 9, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research