Triamterene in lithium-induced nephrogenic diabetes insipidus: a case report
We describe the case of an 81-year-old woman with bipolar treated with lithium and no previous history of diabetes insipidus. She was hospitalized due to disturbance of consciousness and was diagnosed with, hypercalcemia, hyperparathyroidism, and NDI. Parathyroidectomy was contraindicated and parathyroid hormone level was improved insufficiently after cinacalcet initiation, percutaneous ethanol injection therapy was performed for the enlarged parathyroid gland. After improvement in hypercalcemia and unsuccessful indapamide treatment, triamterene was administrated to control polyuria. Lithium is one of the indispensable mai...
Source: CEN Case Reports - August 8, 2020 Category: Urology & Nephrology Source Type: research
Antihypertensives and melanoma: An updated review.
Abstract
Antihypertensive medications are commonly prescribed and well-studied. Given the widespread use and potential side effects, various theories have been made about the relationship between antihypertensives and malignancy, including melanoma. This review describes the current understanding of the most commonly prescribed antihypertensives and their associations with melanoma. The literature demonstrates that diuretics, specifically hydrochlorothiazide and indapamide, may increase the risk of melanoma. While there is no evidence that antihypertensives have a role in melanoma prevention, nonselective ...
Source: Pigment Cell and Melanoma Research - August 4, 2020 Category: Cytology Authors: Williams NM, Vincent LT, Rodriguez GA, Nouri K Tags: Pigment Cell Melanoma Res Source Type: research
An Unusual Cause of Regurgitation and Heartburn In a Patient With Fundoplication
Question: A 60-year-old woman with a history of gastroesophageal reflux disease (submitted to Nissen fundoplication fourteen years before) underwent esophagogastroduodenoscopy (EGD) due to occasional symptoms of heartburn and regurgitation with 6 months of duration. Her usual medication included long time use of indapamide, pravastatin and alprazolam and one-year use of glucosamine and diclofenac for arthritis. She denied alcohol, tobacco, or illicit drug use. Her physical examination and her laboratory findings were unremarkable. (Source: Gastroenterology)
Source: Gastroenterology - March 2, 2020 Category: Gastroenterology Authors: Joel Ferreira-Silva, Rui Morais, Guilherme Macedo Tags: Practical Teaching Case Source Type: research
Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
ConclusionsIn subjects with uncontrolled BP on existing antihypertensive therapy, switching to perindopril arginine 10 mg/indapamide 2.5 mg was associated with statistically significant decreases in BP and higher rates of target BP achievement in all BMI groups, including more than 70% of overweight and obese patients.Trial RegistrationISRCTN ID, ISRCTN14315146 (retrospectively registered 18/11/2019). (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 31, 2020 Category: Cardiology Source Type: research
Cardiac arrhythmia triggered by diuretic-induced hyponatremia.
We present an unusual case of indapamide-induced hyponatremia and hypokalemia complicated by cardiac arrhythmia. The adverse drug reaction was reversible and non-life-threatening, but this case serves as a reminder that careful evaluation and constant monitoring are necessary when prescribing diuretics.
PMID: 31827736 [PubMed] (Source: American Family Physician)
Source: American Family Physician - December 14, 2019 Category: Primary Care Authors: Lu HT, Loo HC, Ng KS, Wong YO, Nordin R Tags: Malays Fam Physician Source Type: research
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
Publication date: Available online 28 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Olga Begou, Kathrin Drabert, Georgios Theodoridis, Dimitrios TsikasAbstractAcetazolamide (molecular mass (MM), 222) belongs to the class of sulfonamides (R-SO2-NH2) and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity. Acetazolamide is excreted unchanged in the urine. Here, we report on the development, validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human urine. The method is based on evaporat...
Source: Journal of Pharmaceutical Analysis - November 29, 2019 Category: Drugs & Pharmacology Source Type: research
Unravelling the inhibitory and cytoprotective potential of diuretics towards amyloid fibrillation.
Abstract
Protein misfolding and deposition of aggregated proteins inside as well as outside of the cells have been associated with several neurotoxic and neurodegenerative disorders like Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. that could be controlled by anti-aggregation methodologies employing either inhibition or disaggregation of toxic aggregates. Also, the Alzheimer's disease develops in later life is somehow related to the high mid-life blood pressure. Therefore the present work targets the amyloid inhibiting potential of diuretics (a class of antihypertensive drugs) - Indapa...
Source: International Journal of Biological Macromolecules - November 15, 2019 Category: Biochemistry Authors: Malik S, Khursheed Siddiqi M, Majid N, Masroor A, Moasfar Ali S, Khan RH Tags: Int J Biol Macromol Source Type: research
Feasibility of 24-h central blood pressure monitoring: experience from multinational clinical trial assessing the efficacy of perindopril/indapamide/amlodipine
Objectives:
Brachial blood pressure (BP) is a predictor of cardiovascular events. Evidence suggests that central BP (CBP) provides additional information for cardiovascular risk assessment. Methods to assess 24-h CBP are now available. Our objective was to assess the feasibility of 24-h CBP monitoring in clinical trials and its ability for drug evaluation.
Methods:
Data are issued from an international phase 3 randomized clinical trial comparing the efficacy of perindopril/indapamide/amlodipine vs. perindopril/indapamide (Per/Ind), in uncontrolled hypertensive patients treated with Per/Ind. 24-h ambulatory BP monitori...
Source: Journal of Hypertension - November 4, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement and hemodynamic aspects Source Type: research
Simultaneous Evaluation of Dissolution and Permeation of Oral Drug Solid Formulations for Predicting Absorption Rate-Limiting Factors and In Vitro-In Vivo Correlations: Case Study Using a Poorly Soluble Weakly Basic Drug.
In this study, the modified biorelevant media with some solubilizers and pH modifiers were integrated into the drug dissolution/absorption simulating system (DDASS). Indapamide, a poorly soluble compound (pKa = 8.8), was selected to validate the applicability of the modified biorelevant media. The elution and permeation dynamics of indapamide were investigated by using appropriate solubilizing agents in the DDASS. The absorption behaviors were analyzed after oral administration of indapamide in beagle dogs. The absorption rate-limiting steps and IVIVCs were predicted from the dissolution-permeation-absorption dynamic param...
Source: AAPS PharmSciTech - October 23, 2019 Category: Drugs & Pharmacology Authors: Li Z, He X, Tian S, Feng G, Huang C, Xun M, Wu Z, Wang Y Tags: AAPS PharmSciTech Source Type: research
Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects
ConclusionsIndependently of BP values achieved, the antihypertensive TFC therapy was more effective than FCT in LVMI reduction and LVH regression, possibly related to drugs’ intrinsic properties and to BPV modulation. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 16, 2019 Category: Drugs & Pharmacology Source Type: research
Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects.
CONCLUSIONS: Independently of BP values achieved, the antihypertensive TFC therapy was more effective than FCT in LVMI reduction and LVH regression, possibly related to drugs' intrinsic properties and to BPV modulation.
PMID: 31627089 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 14, 2019 Category: Drugs & Pharmacology Authors: Mazza A, Townsend DM, Schiavon L, Torin G, Lenti S, Rossetti C, Rigatelli G, Rubello D Tags: Biomed Pharmacother Source Type: research
Efficacy of a new single-pill combination of a thiazide-like diuretic and a calcium channel blocker (indapamide sustained release/amlodipine) in essential hypertension
Objectives:
The current international, 12-week, double-blind, randomized, controlled trial assessed the efficacy and safety of indapamide sustained release/amlodipine single-pill combination (SPC) in mild-to-moderate hypertensive patients.
Methods:
Following a 4-week run-in period on amlodipine 5 mg, patients (SBP 150–180 mmHg and/or DBP (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research
Evaluation of Clinical Acceptability of Perindopril / Indapamide Single-pill Combination in Moderate to Severe Hypertension.
Conclusion: : Perindopril/Indapamide given as a SPC was found to be an effective and well-tolerated antihypertensive combination resulting in rapid blood pressure control in patients with moderate to severe hypertension.
PMID: 31561692 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - September 30, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Molecules, Vol. 24, Pages 2731: Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage
This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibenclamide, hydrocortisone, hydrochlorothiazide, ketoconazole, and sulfathiazole were used as model APIs. The parameters used to assess the supersaturation potential and crystallization kinetics were the maximum supersaturation concentration (Cmax,app), the area under the curve (AUC), and the crystallization rate constant (k). These were compared for freshly spray-dried and aged/cry...
Source: Molecules - July 26, 2019 Category: Chemistry Authors: Khadijah Edueng Denny Mahlin Johan Gr åsjö Olivia Nylander Manish Thakrani Christel A.S. Bergstr öm Tags: Article Source Type: research
Assessment of adherence to antihypertensive drugs in patients with resistant hypertension receiving optimal treatment
ConclusionsIn our study, more than two out of three patients with apparent resistant hypertension optimally treated and without white coat effect, were partially or completely non-adherent to treatment. Assessment of treatment adherence in these high cardiovascular risk patients should be systematically implemented and if possible by more objective methods. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research
