Economic evaluation of single-pill combination of indapamide and amlodipine in the treatment of arterial hypertension in the Polish setting.
CONCLUSIONS: The treatment with SPC of indapamide and amlodipine for hypertensive patients was found to be dominant over FC or at least less expensive then treatment with FC when the difference in effectiveness was neglected. The replacement of FC with SPC shall result in savings from both NHF perspective and NHF and patient's perspective.
PMID: 25987296 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - May 19, 2015 Category: Cardiology Authors: Kawalec P, Holko P, Stawowczyk E, Borowiec Ł, Filipiak KJ Tags: Kardiol Pol Source Type: research
Volume Overload and Adverse Outcomes in Chronic Kidney Disease: Clinical Observational and Animal Studies [Kidney in Cardiovascular Disease]
Conclusions
Volume overload contributes to CKD progression and cardiovascular diseases. Further research is warranted to clarify whether the correction of volume overload would improve outcomes for CKD patients. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 5, 2015 Category: Cardiology Authors: Hung, S.-C., Lai, Y.-S., Kuo, K.-L., Tarng, D.-C. Tags: Kidney in Cardiovascular Disease Source Type: research
Head-to-Head Comparisons of Hydrochlorothiazide With Indapamide and Chlorthalidone: Antihypertensive and Metabolic Effects [Meta-Analysis: Diuretics]
In conclusion, these head-to-head comparisons demonstrate that, like chlorthalidone, INDAP is more potent than HCTZ at commonly prescribed doses without evidence for greater adverse metabolic effects. (Source: Hypertension)
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Roush, G. C., Ernst, M. E., Kostis, J. B., Tandon, S., Sica, D. A. Tags: Clinical Studies, Other Treatment Meta-Analysis: Diuretics Source Type: research
Indapamide: Is It The Better Diuretic for Hypertension? [Editorial Commentaries]
(Source: Hypertension)
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Kaplan, N. M. Tags: Cardiovascular Pharmacology, Other hypertension, Clinical Studies Editorial Commentaries Source Type: research
Not Just Chlorthalidone: Evidence-Based, Single Tablet, Diuretic Alternatives to Hydrochlorothiazide for Hypertension
In conclusion, based on both scientific and practical grounds, new prescriptions for HCTZ are rarely justified. (Source: Current Hypertension Reports)
Source: Current Hypertension Reports - March 28, 2015 Category: Primary Care Source Type: research
Prevention of metabolic disorders with telmisartan and indapamide in a Chinese population with high-normal blood pressure
g Lu & Wei Zhang (Source: Hypertension Research)
Source: Hypertension Research - February 5, 2015 Category: Cardiology Authors: Jie PengYingxin ZhaoHua ZhangZhendong LiuZhihao WangMengxiong TangMing ZhongFanghong LuWei Zhang Tags: abdominal obesity high-normal blood pressure metabolic syndrome pharmacoeconomics Source Type: research
Dual-directional regulation of drug permeating amount by combining the technique of ion-pair complexation with chemical enhancers for the synchronous permeation of indapamide and bisoprolol in their compound patch through rabbit skin.
Abstract
To achieve the synchronous skin permeation of indapamide (IND) and bisoprolol (BSP) in their compound patch, the technique of ion-pair complexation and chemical enhancers was combined to dual-directionally regulate drug permeating amounts. Ion-pair complexes of BSP and various organic acids were formed by the technique of ion-pair complexation. Among the complexes formed, bisoprolol tartrate (BSP.T) down-regulated the permeating amount of BSP to the same extent as that of IND. Then, to simultaneously up-regulate the amounts of the two drugs, an enhancer combination of 15.8% Span80 (SP), 6.0% Azone...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 4, 2015 Category: Drugs & Pharmacology Authors: Song W, Cun D, Quan P, Liu N, Chen Y, Cui H, Xiang R, Fang L Tags: Eur J Pharm Biopharm Source Type: research
Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial
Publication date: Available online 26 January 2015 Source:The Lancet Author(s): Michel Azizi , Marc Sapoval , Philippe Gosse , Matthieu Monge , Guillaume Bobrie , Pascal Delsart , Marco Midulla , Claire Mounier-Véhier , Pierre-Yves Courand , Pierre Lantelme , Thierry Denolle , Caroline Dourmap-Collas , Hervé Trillaud , Helena Pereira , Pierre-François Plouin , Gilles Chatellier Background Conflicting blood pressure-lowering effects of catheter-based renal artery denervation have been reported in patients with resistant hypertension. We compared the ambulatory blood pressure-lowering efficacy and safe...
Source: The Lancet - January 27, 2015 Category: Journals (General) Source Type: research
Comparison of single-pill strategies first line in hypertension: perindopril/amlodipine versus valsartan/amlodipine
Objectives: An international double-blind, parallel-group, randomized controlled trial was performed to determine the efficacy and safety of a new first-line strategy in mild to moderate hypertension based on a single-pill combination of perindopril/amlodipine versus a validated stepped-care strategy (initiation with valsartan monotherapy, up-titrating to valsartan/amlodipine after 2 months).
Methods: At inclusion, patients received perindopril/amlodipine 3.5/2.5 mg or valsartan 80 mg. At 1, 2, and 3 months, patients were up-titrated if they had uncontrolled hypertension (≥140/90 mmHg). The up-titration steps were:...
Source: Journal of Hypertension - January 6, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs – Overview and meta-analyses
Conclusion: BP lowering by all classes of antihypertensive drugs is accompanied by significant reductions of stroke and major cardiovascular events. This supports the concept that reduction of these events is because of BP lowering per se rather than specific drug properties. However, evidence of risk reduction of other events and particularly mortality was obtained so far with some drug classes only. As a result of marked differences in the trial design, total cardiovascular risk, SBP/DBP differences and statistical power, comparisons of meta-analyses of different drug-specific placebo-controlled RCTs appear unwarranted. ...
Source: Journal of Hypertension - January 6, 2015 Category: Cardiology Tags: Reviews and Meta-Analyses Source Type: research
COPD and concomitant arterial hypertension: The efficacy and safety of slow-release formulation of indapamide
Conclusions: Using of indapamide SR in complex therapy of COPD and concomitant hypertension is efficacy and safety antihypertensive treatment that doesn't affect the existing hyperinflation and electrolytes balance. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Nersesyan, Z., Ovcharenko, S., Morozova, T. Tags: 1.12 Clinical Problems - COPD Source Type: research
Predicting the Effects of Blood Pressure-Lowering Treatment on Major Cardiovascular Events for Individual Patients With Type 2 Diabetes Mellitus: Results From Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation [Clinical Trials]
In conclusion, a multivariable treatment algorithm can identify those individuals who benefit most from blood pressure–lowering therapy in terms of ARR of major adverse cardiovascular events and may be used to guide treatment decisions in individual patients with diabetes.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT00145925. (Source: Hypertension)
Source: Hypertension - December 10, 2014 Category: Cardiology Authors: van der Leeuw, J., Visseren, F. L. J., Woodward, M., Zoungas, S., Kengne, A. P., van der Graaf, Y., Glasziou, P., Hamet, P., MacMahon, S., Poulter, N., Grobbee, D. E., Chalmers, J. Tags: Cardiovascular Pharmacology, Type 2 diabetes Clinical Trials Source Type: research
Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension
Conclusion In patients requiring combination antihypertensive treatment, the regimen of perindopril alone or its FDC with Indapamide or amlodipine reduces blood pressure effectively, resulting in high rates of blood pressure control over the short term, with a low frequency of side effects including cough and pedal edema. (Source: Indian Heart Journal)
Source: Indian Heart Journal - November 29, 2014 Category: Cardiology Source Type: research
HPLC-PDA analysis of ACE-inhibitors, hydrochlorthiazide and indapamide utilizing Design of Experiments
Publication date: Available online 18 November 2014 Source:Arabian Journal of Chemistry Author(s): Eyad Rashed Dawud , Ashok K. Shakya A simple, rapid, precise, accurate and sensitive high performance liquid chromatographic method has been developed for simultaneous determination of ACE inhibitors with hydrochlorothiazide and indapamide in pharmaceutical formulations. ‘Design of Experiments’ (DoE) using ‘central composite design’ (CCD) was applied to facilitate method development and optimization. Mobile phase was optimized utilizing response surface methodology using Design Expert software. Chromatographic s...
Source: Arabian Journal of Chemistry - November 18, 2014 Category: Chemistry Source Type: research
In vitro–in vivo correlations for three different commercial immediate-release indapamide tablets
Drug Development and Industrial Pharmacy, Volume 40, Issue 12, Page 1670-1676, December 2014. (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - November 13, 2014 Category: Drugs & Pharmacology Tags: article Source Type: research
