Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage [Cardiovascular Surgery]
BackgroundDelayed cerebral infarction (DCI) is a major cause of morbidities after aneurysmal subarachnoid hemorrhage (SAH) and typically starts at day 4 to 7 after initial hemorrhage. MicroRNAs (miRNAs) play an important role in posttranscriptional gene expression control, and distinctive patterns of circulating miRNA changes have been identified for some diseases. We aimed to investigate miRNAs that characterize SAH patients with DCI compared with those without DCI.Methods and ResultsCirculating miRNAs were collected on day 7 after SAH in healthy, SAH‐free controls (n=20), SAH patients with DCI (n=20), and SAH patients ...
Source: JAHA:Journal of the American Heart Association - April 25, 2017 Category: Cardiology Authors: Lu, G., Wong, M. S., Xiong, M. Z. Q., Leung, C. K., Su, X. W., Zhou, J. Y., Poon, W. S., Zheng, V. Z. Y., Chan, W. Y., Wong, G. K. C. Tags: Intracranial Hemorrhage Original Research Source Type: research

Richard E. Kerber, MD, 1939-2016 [In Memoriam]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Gutterman, D., Mark, A. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Echocardiography In Memoriam Source Type: research

Implementing Cardiovascular Risk Prediction in Clinical Practice: The Future Is Now [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Karmali, K. N., Lloyd-Jones, D. M. Tags: Cardiovascular Disease, Epidemiology, Primary Prevention, Risk Factors Editorial Source Type: research

Adverse Events as End Points: The Need to Account for Both Sides of the Same Coin [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Aizpuru, F. Tags: Clinical Studies Editorial Source Type: research

Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later [Epidemiology]
ConclusionsHigher maternal dietary protein intake at the expense of carbohydrates was associated with a modest increase in offspring blood pressure in young adulthood. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Hrolfsdottir, L., Halldorsson, T. I., Rytter, D., Bech, B. H., Birgisdottir, B. E., Gunnarsdottir, I., Granstrom, C., Henriksen, T. B., Olsen, S. F., Maslova, E. Tags: Cardiovascular Disease, Diet and Nutrition, Epidemiology, Pregnancy, High Blood Pressure Original Research Source Type: research

Clinical Significance of Postinfarct Fever in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study [Coronary Heart Disease]
BackgroundLittle is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST‐segment elevation myocardial infarction.Methods and ResultsIn 276 patients undergoing primary percutaneous coronary intervention for ST‐segment elevation myocardial infarction, cardiac magnetic resonance imaging was performed a median of 3.4 days after the index procedure. Forty‐five patients had postinfarct fever (peak body temperature within 4 days after primary percutaneous coronary intervention ≥37.7°C; Fever group) whereas 231 did not (no‐F...
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Jang, W. J., Yang, J. H., Song, Y. B., Chun, W. J., Oh, J. H., Park, Y. H., Lee, M. R., Hwang, J. K., Hwang, J.-W., Hahn, J.-Y., Choi, S.-H., Lee, S.-C., Choe, Y. H., Gwon, H.-C. Tags: Myocardial Infarction, Magnetic Resonance Imaging (MRI), Percutaneous Coronary Intervention, Coronary Artery Disease Original Research Source Type: research

Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection [Coronary Heart Disease]
ConclusionsAn integrated collection of end points and serious AEs is feasible in a multinational trial and illustrates the shared characteristics of events. Tailoring event collection to fit the phase and purpose of the trial is achievable and informative.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00831441. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Guimaraes, P. O., Lopes, R. D., Stevens, S. R., Zimerman, A., Wruck, L., James, S. K., Haque, G., Giraldez, R. R. C. V., Alexander, J. H., Alexander, K. P. Tags: Clinical Studies, Cardiovascular Disease, Myocardial Infarction, Acute Coronary Syndromes Original Research Source Type: research

Short Length of Stay After Elective Transfemoral Transcatheter Aortic Valve Replacement is Not Associated With Increased Early or Late Readmission Risk [Valvular Heart Disease]
ConclusionsAmong elderly survivors of elective transfemoral TAVR, a short postprocedural length of stay was not associated with an increased risk readmission within 30 days or 1 year. However, the risk of 1‐year readmission increased with longer post‐TAVR lengths of stay. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Sud, M., Qui, F., Austin, P. C., Ko, D. T., Wood, D., Czarnecki, A., Patel, V., Lee, D. S., Wijeysundera, H. C. Tags: Valvular Heart Disease, Quality and Outcomes Original Research Source Type: research

Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients [Heart Failure]
ConclusionsAmong a large national cohort of human immunodeficiency virus–infected patients, TDF use was strongly associated with lower risk of incident HF. These findings warrant confirmation in other populations, both with TDF and the recently approved tenofovir alafenamide fumarate. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Chen, R., Scherzer, R., Hsue, P. Y., Jotwani, V., Estrella, M. M., Horberg, M. A., Grunfeld, C., Shlipak, M. G. Tags: Risk Factors, Cardiomyopathy, Heart Failure Original Research Source Type: research

Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves [Valvular Heart Disease]
ConclusionsIn AVICs of calcified valves, increased levels of miR‐486 induce myofibroblastic transition to upregulate Runx2 and Osx expression and synergize with miR‐204 deficiency to elevate cellular and valvular pro‐osteogenic activity. These novel findings indicate that modulation of the epigenetic mechanism underlying valvular pro‐osteogenic activity has therapeutic potential for prevention of calcific aortic valve disease progression. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Song, R., Fullerton, D. A., Ao, L., Zhao, K.-s., Reece, T. B., Cleveland, J. C., Meng, X. Tags: Cell Biology/Structural Biology, Cell Signaling/Signal Transduction, Vascular Biology, Gene Expression & Regulation, Valvular Heart Disease Original Research Source Type: research

Comparative Effectiveness and Safety of Dabigatran and Rivaroxaban in Atrial Fibrillation Patients [Arrhythmia and Electrophysiology]
ConclusionsRivaroxaban therapy was associated with a statistically significant increase in all‐cause death compared with dabigatran therapy in atrial fibrillation patients. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Lai, C.-L., Chen, H.-M., Liao, M.-T., Lin, T.-T., Chan, K. A. Tags: Arrhythmias, Anticoagulants, Pharmacology, Cerebrovascular Disease/Stroke Original Research Source Type: research

Total Thrombus-formation Analysis System Predicts Periprocedural Bleeding Events in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention [Interventional Cardiology]
ConclusionsPL24‐AUC10 measured by the Total Thrombus‐formation Analysis System is a potentially useful predictor of periprocedural bleeding events in coronary artery disease patients undergoing elective percutaneous coronary intervention. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Oimatsu, Y., Kaikita, K., Ishii, M., Mitsuse, T., Ito, M., Arima, Y., Sueta, D., Takahashi, A., Iwashita, S., Yamamoto, E., Kojima, S., Hokimoto, S., Tsujita, K. Tags: Complications, Coronary Artery Disease Original Research Source Type: research

Use and Customization of Risk Scores for Predicting Cardiovascular Events Using Electronic Health Record Data [Health Services and Outcomes Research]
ConclusionsWe conclude that published cardiovascular risk models can be successfully applied to EHD to estimate cardiovascular risk; the FRS remains valid and is not obsolete; and model refitting does not meaningfully improve the accuracy of risk estimates. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Wolfson, J., Vock, D. M., Bandyopadhyay, S., Kottke, T., Vazquez-Benitez, G., Johnson, P., Adomavicius, G., O'Connor, P. J. Tags: Cardiovascular Disease, Risk Factors, Quality and Outcomes Original Research Source Type: research

Marital History and Survival After Stroke [Corrections]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Tags: Correction Source Type: research

Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England [Epidemiology]
ConclusionsAlthough the absolute risk of first stroke is low in women of childbearing age, healthcare professionals should be aware of a considerable increase in relative risk during the peripartum and early postpartum periods. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Ban, L., Sprigg, N., Abdul Sultan, A., Nelson-Piercy, C., Bath, P. M., Ludvigsson, J. F., Stephansson, O., Tata, L. J. Tags: Epidemiology, Pregnancy, Women, Cerebrovascular Disease/Stroke Original Research Source Type: research

In Situ Laser Fenestration Is a Feasible Method for Revascularization of Aortic Arch During Thoracic Endovascular Aortic Repair [Cardiovascular Surgery]
ConclusionsIn situ laser fenestration is a feasible, effective, rapid, repeatable, and safe option for the reconstruction of aortic arch during thoracic endovascular aortic repair, which might be available to revascularize the 3 branches. However, follow‐up periods should be extended to evaluate the robustness of this technique. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Qin, J., Zhao, Z., Wang, R., Ye, K., Li, W., Liu, X., Liu, G., Cui, C., Shi, H., Peng, Z., Yuan, F., Yang, X., Lu, M., Huang, X., Jiang, M., Wang, X., Yin, M., Lu, X. Tags: Aneurysm, Aortic Dissection, Thrombosis Original Research Source Type: research

Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy [Heart Failure]
ConclusionsThese data indicated that TIM50 could attenuate pathological cardiac hypertrophy primarily by reducing oxidative stress. TIM50 could be a promising target for the prevention and therapy of cardiac hypertrophy and heart failure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Tang, K., Zhao, Y., Li, H., Zhu, M., Li, W., Liu, W., Zhu, G., Xu, D., Peng, W., Xu, Y.-w. Tags: Basic Science Research, Hypertrophy Original Research Source Type: research

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis [Imaging]
ConclusionsCAC progression was associated with incident HF and modestly increased LV end diastolic volume and LV end systolic volume at follow‐up exam independent of overt coronary heart disease. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 20, 2017 Category: Cardiology Authors: Bakhshi, H., Ambale-Venkatesh, B., Yang, X., Ostovaneh, M. R., Wu, C. O., Budoff, M., Bahrami, H., Wong, N. D., Bluemke, D. A., Lima, J. A. C. Tags: Heart Failure, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research

Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure [Hypertension]
ConclusionsBrain angiotensin II seems to be involved in cognitive impairment and brain injury in AD, which is associated with oxidative stress, inflammation, and cerebral amyloid angiopathy. Further, brain angiotensin II may participate in cardiac disease and sarcopenia observed in AD. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 20, 2017 Category: Cardiology Authors: Takane, K., Hasegawa, Y., Lin, B., Koibuchi, N., Cao, C., Yokoo, T., Kim-Mitsuyama, S. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Basic Science Research, Cognitive Impairment Original Research Source Type: research

Comparative Safety of Sulfonylurea and Metformin Monotherapy on the Risk of Heart Failure: A Cohort Study [Health Services and Outcomes Research]
BackgroundMedications that impact insulin sensitivity or cause weight gain may increase heart failure risk. Our aim was to compare heart failure and cardiovascular death outcomes among patients initiating sulfonylureas for diabetes mellitus treatment versus metformin.Methods and ResultsNational Veterans Health Administration databases were linked to Medicare, Medicaid, and National Death Index data. Veterans aged ≥18 years who initiated metformin or sulfonylureas between 2001 and 2011 and whose creatinine was (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 19, 2017 Category: Cardiology Authors: Roumie, C. L., Min, J. Y., D'Agostino McGowan, L., Presley, C., Grijalva, C. G., Hackstadt, A. J., Hung, A. M., Greevy, R. A., Elasy, T., Griffin, M. R. Tags: Diabetes, Type 2, Heart Failure, Complications, Quality and Outcomes Original Research Source Type: research

Association of Magnet Status With Hospitalization Outcomes for Ischemic Stroke Patients [Health Services and Outcomes Research]
ConclusionsUsing a comprehensive all‐payer cohort of patients with ischemic stroke in New York State, we identified an association of treatment in Magnet hospitals with lower case‐fatality, discharge to a facility, and length of stay. Further research into the factors contributing to the superiority of Magnet hospitals in stroke care is warranted. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 18, 2017 Category: Cardiology Authors: Bekelis, K., Missios, S., MacKenzie, T. A. Tags: Epidemiology, Cost-Effectiveness, Ethics and Policy, Health Services, Quality and Outcomes Original Research Source Type: research

Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study [Imaging]
BackgroundSubclinical left ventricular (LV) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have been poorly considered. We investigated the cross‐sectional relationship between LV dysfunction and structural/functional measures of the brain and explored the role of potential mechanisms.Method and ResultsA total of 1338 individuals (69±6 years) from the Southall and Brent Revisited study underwent echocardiography for systolic (tissue Doppler imaging peak systolic wave) and diastolic (left atrial diameter) assessment. Cognitive function was assessed and ...
Source: JAHA:Journal of the American Heart Association - April 18, 2017 Category: Cardiology Authors: Park, C. M., Williams, E. D., Chaturvedi, N., Tillin, T., Stewart, R. J., Richards, M., Shibata, D., Mayet, J., Hughes, A. D. Tags: Clinical Studies, Echocardiography, Cognitive Impairment Original Research Source Type: research

Incremental Value of Transthoracic Doppler Echocardiography-Assessed Coronary Flow Reserve in Patients With Suspected Myocardial Ischemia Undergoing Myocardial Perfusion Scintigraphy [Coronary Heart Disease]
BackgroundAdenosine‐assisted transthoracic Doppler‐derived coronary flow reserve (TDE‐CFR) reflects coronary vascular function. The prognostic and incremental value of left anterior descending coronary artery TDE‐CFR above myocardial perfusion scintigraphy in patients with suspected myocardial ischemia has not yet been studied.Methods and ResultsThree hundred seventy‐one patients (mean age, 62.3±8.7 years; 46.8% males) referred to myocardial perfusion scintigraphy attributed to suspected myocardial ischemia were included in the study. The TDE‐CFR result was blinded to the referring physician. Patien...
Source: JAHA:Journal of the American Heart Association - April 18, 2017 Category: Cardiology Authors: Gan, L.-M., Svedlund, S., Wittfeldt, A., Eklund, C., Gao, S., Matejka, G., Jeppsson, A., Albertsson, P., Omerovic, E., Lerman, A. Tags: Coronary Circulation, Ischemia, Prognosis, Ultrasound Original Research Source Type: research

Association Between Chronic Kidney Disease and Rates of Transfusion and Progression to End-Stage Renal Disease in Patients Undergoing Transradial Versus Transfemoral Cardiac Catheterization—An Analysis From the Veterans Affairs Clinical Assessment Reporting and Tracking (CART) Program [Interventional Cardiology]
BackgroundPatients with chronic kidney disease (CKD) are at increased risk for bleeding, transfusion, and dialysis after cardiac catheterization. Whether rates of these complications are increased in this high‐risk population undergoing transradial access compared with transfemoral access is unknown.Methods and ResultsFrom the Veterans Affairs (VA) Clinical Assessment Reporting and Tracking program, we identified 229 108 patients undergoing cardiac catheterization between 2007 and 2014, of which 48 155 (21.0%) had baseline glomerular filtration rate (GFR) between 15 and 59 mL/min. We used multivariable Cox...
Source: JAHA:Journal of the American Heart Association - April 18, 2017 Category: Cardiology Authors: Vora, A. N., Stanislawski, M., Grunwald, G. K., Plomondon, M. E., Rumsfeld, J. S., Maddox, T. M., Vidovich, M. I., Woody, W., Nallamothu, B. K., Gurm, H. S., Rao, S. V. Tags: Percutaneous Coronary Intervention, Quality and Outcomes, Coronary Artery Disease Original Research Source Type: research

Smokers and Postcessation Weight Gain After Acute Coronary Syndrome [Epidemiology]
ConclusionsFollowing an ACS, significant weight is gained by patients who quit smoking. Weight‐management interventions among smokers who quit after ACS should be a focus of investigation in future research so that the cardiovascular benefits achieved by smoking cessation are not offset by weight gain in this high‐risk population.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00794573. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 18, 2017 Category: Cardiology Authors: Dehghani, P., Habib, B., Windle, S. B., Roy, N., Old, W., Grondin, F. R., Bata, I., Iskander, A., Lauzon, C., Srivastava, N., Clarke, A., Cassavar, D., Dion, D., Haught, H., Mehta, S. R., Baril, J.-F., Lambert, C., Madan, M., Abramson, B. L., Eisenberg, M Tags: Clinical Studies, Cardiovascular Disease, Lifestyle, Secondary Prevention Original Research Source Type: research

Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy [Arrhythmia and Electrophysiology]
ConclusionsThis DM mutant mouse model presented with clinical myofibril ultrastructural abnormality and cardiac arrhythmias, including atrial tachyarrhythmias, atrioventricular block, and ventricular tachyarrhythmias. Optical mapping studies revealed prolonged action potential duration and slow conduction velocity in the DM mice, leading to vulnerability of spatially discordant alternans and ventricular arrhythmia induction to pacing. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 17, 2017 Category: Cardiology Authors: Chou, C.-C., Chang, P.-C., Wei, Y.-C., Lee, K.-Y. Tags: Arrhythmias, Basic Science Research Original Research Source Type: research

Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist [Vascular Medicine]
ConclusionsOur results suggest that KP‐10 may contribute to accelerate the progression and instability of atheromatous plaques, leading to plaque rupture. The GPR54 antagonist may be useful for prevention and treatment of atherosclerosis. Thus, the KP‐10/GPR54 system may serve as a novel therapeutic target for atherosclerotic diseases. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 14, 2017 Category: Cardiology Authors: Sato, K., Shirai, R., Hontani, M., Shinooka, R., Hasegawa, A., Kichise, T., Yamashita, T., Yoshizawa, H., Watanabe, R., Matsuyama, T.–a., Ishibashi-Ueda, H., Koba, S., Kobayashi, Y., Hirano, T., Watanabe, T. Tags: Vascular Biology, Atherosclerosis, Coronary Artery Disease, Vascular Disease Original Research Source Type: research

Growth Differentiation Factor 15 at 1 Month After an Acute Coronary Syndrome Is Associated With Increased Risk of Maȷor Bleeding [Coronary Heart Disease]
ConclusionsGDF‐15 at 1 month after an ACS is related to the risk of bleeding during DAPT and provides additional information on the bleeding risk beyond baseline GDF‐15 levels. GDF‐15 levels may therefore be useful as part of decision support concerning long‐term antithrombotic treatment in patients post‐ACS.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00391872. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 14, 2017 Category: Cardiology Authors: Lindholm, D., Hagstrom, E., James, S. K., Becker, R. C., Cannon, C. P., Himmelmann, A., Katus, H. A., Maurer, G., Lopez-Sendon, J. L., Steg, P. G., Storey, R. F., Siegbahn, A., Wallentin, L. Tags: Biomarkers Original Research Source Type: research

Characteristics of Earlier Versus Delayed Presentation of Very Late Drug-Eluting Stent Thrombosis: An Optical Coherence Tomographic Study [Coronary Heart Disease]
ConclusionsThe pathological mechanisms of very late DES thrombosis changed over time. Delayed neointimal healing remained a substantial substrate for VLST, even long after DES implantation. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 14, 2017 Category: Cardiology Authors: Lee, S.-Y., Ahn, J.-M., Mintz, G. S., Hur, S.-H., Choi, S.-Y., Kim, S.-W., Cho, J. M., Hong, S. J., Kim, J. W., Hong, Y. J., Lee, S.-G., Shin, D.-H., Kim, J.-S., Kim, B.-K., Ko, Y.-G., Choi, D., Jang, Y., Park, S.-J., Hong, M.-K. Tags: Optical Coherence Tomography (OCT), Percutaneous Coronary Intervention, Stent Original Research Source Type: research

Differences in Short- and Long-Term Mortality Associated With BMI Following Coronary Revascularization [Coronary Heart Disease]
ConclusionsOverweight was associated with lower mortality following CABG and PCI. Greater long‐term mortality in patients with obese class III following PCI, especially in those with high‐risk coronary anatomy without diabetes mellitus, warrants further investigation. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 14, 2017 Category: Cardiology Authors: Terada, T., Forhan, M., Norris, C. M., Qiu, W., Padwal, R., Sharma, A. M., Nagendran, J., Johnson, J. A. Tags: Diabetes, Type 2, Obesity, Cardiovascular Surgery, Complications, Mortality/Survival Original Research Source Type: research

Long-Term Follow-up of the PADI Trial: Percutaneous Transluminal Angioplasty Versus Drug-Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia [Vascular Medicine]
ConclusionsBoth clinical and morphological long‐term results after treatment of infrapopliteal lesions in patients with critical limb ischemia are improved with DES compared with PTA‐BMS.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00471289. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 14, 2017 Category: Cardiology Authors: Spreen, M. I., Martens, J. M., Knippenberg, B., van Dijk, L. C., de Vries, J.-P. P. M., Vos, J. A., de Borst, G. J., Vonken, E.-J. P. A., Bijlstra, O. D., Wever, J. J., Statius van Eps, R. G., Mali, W. P. T. M., van Overhagen, H. Tags: Ischemia, Angiography, Revascularization, Stent, Peripheral Vascular Disease Original Research Source Type: research

Statin Eligibility and Outpatient Care Prior to ST-Segment Elevation Myocardial Infarction [Preventive Cardiology]
ConclusionsIn a large cohort of STEMI patients, application of American College of Cardiology/American Heart Association guidelines more than doubled pre‐STEMI statin eligibility compared with Third Report of the Adult Treatment Panel guidelines. However, access to and utilization of health care, a necessity for guideline implementation, was suboptimal prior to STEMI. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 12, 2017 Category: Cardiology Authors: Miedema, M. D., Garberich, R. F., Schnaidt, L. J., Peterson, E., Strauss, C., Sharkey, S., Knickelbine, T., Newell, M. C., Henry, T. D. Tags: Lipids and Cholesterol, Epidemiology, Statements and Guidelines, Acute Coronary Syndromes Original Research Source Type: research

In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood [Molecular Cardiology]
BackgroundParticulate matter (PM; PM2.5 [PM with diameters of (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Tanwar, V., Gorr, M. W., Velten, M., Eichenseer, C. M., Long, V. P., Bonilla, I. M., Shettigar, V., Ziolo, M. T., Davis, J. P., Baine, S. H., Carnes, C. A., Wold, L. E. Tags: Animal Models of Human Disease, Calcium Cycling/Excitation-Contraction Coupling, Contractile Function Original Research Source Type: research

Relationship Between Peak Troponin Values and Long-Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes [Coronary Heart Disease]
BackgroundThe relationship between troponin level and outcomes among patients with non‐ST‐segment elevation ACS is established, but the relationship of troponin level with long‐term outcomes among medically managed non‐ST‐segment elevation ACS patients receiving contemporary antiplatelet therapy is inadequately defined.Methods and ResultsIn 6763 medically managed non‐ST‐segment elevation ACS patients randomized in TRILOGY ACS (Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes) (prasugrel versus clopidogrel), we examined relationships between categories o...
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Goldstein, S. A., Newby, L. K., Cyr, D. D., Neely, M., Luscher, T. F., Brown, E. B., White, H. D., Ohman, E. M., Roe, M. T., Hamm, C. W. Tags: Acute Coronary Syndromes Original Research Source Type: research

Health Literacy and Awareness of Atrial Fibrillation [Arrhythmia and Electrophysiology]
ConclusionsLower health literacy is independently associated with less awareness of AF diagnosis. Strategies designed to increase patient awareness of AF and its complications are warranted among individuals with limited health literacy. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Reading, S. R., Go, A. S., Fang, M. C., Singer, D. E., Liu, I.–L. A., Black, M. H., Udaltsova, N., Reynolds, K., the Anticoagulation and Risk Factors in Atrial Fibrillation-Cardiovascular Research Network (ATRIA-CVRN) Investigators Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Health Services Original Research Source Type: research

Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome [Heart Failure]
ConclusionsAlthough the small arteries studied were not cardiac in origin, our results support a role for small artery remodeling in the development of diastolic dysfunction in humans. Further direct examination of the structure and function of the myocardial resistance vasculature is now warranted, to elucidate the temporal association between metabolic risk factors, small artery injury, and diastolic impairment. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 11, 2017 Category: Cardiology Authors: Khavandi, K., Aghamohammadzadeh, R., Luckie, M., Brownrigg, J., Alam, U., Khattar, R., Malik, R. A., Heagerty, A. M., Greenstein, A. S. Tags: Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Heart Failure, Metabolic Syndrome, Hypertension Original Research Source Type: research

Optimal Timing of Complete Revascularization in Acute Coronary Syndrome: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
ConclusionsOur results suggest that single‐stage complete revascularization is safe. There also appears to be a trend towards lower long‐term risks of mortality and major adverse cardiovascular events; however, additional randomized controlled trials are required to confirm the potential benefits of single‐stage multivessel percutaneous coronary intervention. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Gaffar, R., Habib, B., Filion, K. B., Reynier, P., Eisenberg, M. J. Tags: Percutaneous Coronary Intervention, Revascularization, Meta Analysis, Acute Coronary Syndromes, Coronary Artery Disease Systematic Review and Meta ‐ Source Type: research

Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study [Genetics]
ConclusionsFuture studies are needed to replicate and/or determine the causal variants driving our associations and explore clinical applications for those consistently associated with CVEs. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Shendre, A., Irvin, M. R., Wiener, H., Zhi, D., Limdi, N. A., Overton, E. T., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Race and Ethnicity, Risk Factors, Heart Failure Original Research Source Type: research

Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy [Arrhythmia and Electrophysiology]
ConclusionsTollip deficiency selectively leads to enlarged yet stable atherosclerotic plaques, increased circulating lipids, liver steatosis, and reduced inflammation. Compromised lipophagy and reduced expression of inflammatory mediators due to Tollip deficiency may be the underlying causes. Our data suggest that lipid accumulation and inflammation may be intertwined yet independent processes during the progression of atherosclerosis and steatosis. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Chen, K., Yuan, R., Zhang, Y., Geng, S., Li, L. Tags: Inflammation, Mechanisms Original Research Source Type: research

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With {alpha}+Thalassemia [Epidemiology]
ConclusionsThese data suggest that the presence of α+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Etyang, A. O., Khayeka-Wandabwa, C., Kapesa, S., Muthumbi, E., Odipo, E., Wamukoya, M., Ngomi, N., Haregu, T., Kyobutungi, C., Tendwa, M., Makale, J., Macharia, A., Cruickshank, J. K., Smeeth, L., Scott, J. A. G., Williams, T. N. Tags: Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Genetics, High Blood Pressure Original Research Source Type: research

Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice [Stroke]
ConclusionsWe conclude that brain ischemia induces the formation of β‐hydroxybutyrate (ketogenesis) in the liver and the consumption of β‐hydroxybutyrate in the brain. This effect seems to be mediated by β‐adrenergic receptors. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Koch, K., Berressem, D., Konietzka, J., Thinnes, A., Eckert, G. P., Klein, J. Tags: Ischemia, Metabolism, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Research Source Type: research

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion [Molecular Cardiology]
ConclusionsFibroblast nuclei possess AT1R and AT2R binding sites that are coupled to intranuclear Ca2+‐mobilization and NO liberation, respectively. Intracellular Ang‐II signaling regulates fibroblast proliferation, collagen gene expression, and collagen secretion. Heart failure upregulates Ang‐II intracrine signaling‐components in atrial fibroblasts. These results show for the first time that nuclear angiotensin‐II receptor activation and intracrine Ang‐II signaling control fibroblast function and may have pathophysiological significance. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Tadevosyan, A., Xiao, J., Surinkaew, S., Naud, P., Merlen, C., Harada, M., Qi, X., Chatenet, D., Fournier, A., Allen, B. G., Nattel, S. Tags: Arrhythmias, Cell Signaling/Signal Transduction, Fibrosis Original Research Source Type: research

Associations of Blood Pressure Dipping Patterns With Left Ventricular Mass and Left Ventricular Hypertrophy in Blacks: The Jackson Heart Study [Hypertension]
We examined the associations of BP dipping patterns (dipping, nondipping, and reverse dipping) with cardiovascular target organ damage (left ventricular mass index and left ventricular hypertrophy), among participants from the Jackson Heart Study, an exclusively black population–based cohort.Methods and ResultsAnalyses included 1015 participants who completed ambulatory BP monitoring and had echocardiography data from the baseline visit. Participants were categorized based on the nighttime to daytime systolic BP ratio into 3 patterns: dipping pattern (≤0.90), nondipping pattern (>0.90 to ≤1.00), and reverse ...
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Abdalla, M., Caughey, M. C., Tanner, R. M., Booth, J. N., Diaz, K. M., Anstey, D. E., Sims, M., Ravenell, J., Muntner, P., Viera, A. J., Shimbo, D. Tags: Epidemiology, Race and Ethnicity, Hypertension Original Research Source Type: research

Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy [Cardiovascular Surgery]
BackgroundWhen transplanted into failing heart, autologous somatic tissue–derived cells yield functional recovery via paracrine effects that enhance native regeneration. However, the therapeutic effects are modest. We developed a method in which scaffold‐free cell sheets are attached to the epicardial surface to maximize paracrine effects. This Phase I clinical trial tested whether transplanting autologous cell–sheets derived from skeletal muscle is feasible, safe, and effective for treating severe congestive heart failure.Methods and ResultsFifteen ischemic cardiomyopathy patients and 12 patients with dilate...
Source: JAHA:Journal of the American Heart Association - April 5, 2017 Category: Cardiology Authors: Miyagawa, S., Domae, K., Yoshikawa, Y., Fukushima, S., Nakamura, T., Saito, A., Sakata, Y., Hamada, S., Toda, K., Pak, K., Takeuchi, M., Sawa, Y. Tags: Cardiomyopathy, Cardiovascular Surgery Original Research Source Type: research

Circulating microRNAs: Potential Markers of Cardiotoxicity in Children and Young Adults Treated With Anthracycline Chemotherapy [Heart Failure]
ConclusionsIn this pilot study, cardiac‐related plasma miRNAs are dysregulated following ACs. Plasma miR‐29b and ‐499 are acutely elevated post‐AC, with dose response relationships observed with anthracycline dose and markers of cardiac injury. Further evaluation of miRNAs may provide mechanistic insight into AC‐induced cardiotoxicity and yield biomarkers to facilitate earlier intervention to mitigate cardiotoxicity. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 4, 2017 Category: Cardiology Authors: Leger, K. J., Leonard, D., Nielson, D., de Lemos, J. A., Mammen, P. P. A., Winick, N. J. Tags: Biomarkers, Pediatrics, Cardiomyopathy, Complications Original Research Source Type: research

Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy [Heart Failure]
ConclusionsFactors other than focal myocardial damage detectable by LGE explain the initial transient depressions in baseline left ventricular ejection fraction, yet focal myocardial damage may contribute to persistent myocardial dysfunction and hinder recovery in a small minority. Most women exhibit favorable changes in ventricular function over 6 months.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01085955. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 3, 2017 Category: Cardiology Authors: Schelbert, E. B., Elkayam, U., Cooper, L. T., Givertz, M. M., Alexis, J. D., Briller, J., Felker, G. M., Chaparro, S., Kealey, A., Pisarcik, J., Fett, J. D., McNamara, D. M., the Investigations of Pregnancy Associated Cardiomyopathy (IPAC) Investigators Tags: Cardiomyopathy, Heart Failure Original Research Source Type: research

Cardioprotective Effects of Intracoronary Morphine in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Prospective, Randomized Trial [Coronary Heart Disease]
ConclusionsIntracoronary morphine administration could not reduce myocardial infarct size in ST‐elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01738100. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 3, 2017 Category: Cardiology Authors: Gwag, H. B., Kim, E. K., Park, T. K., Lee, J. M., Yang, J. H., Song, Y. B., Choi, J.-H., Choi, S.-H., Lee, S. H., Chang, S.-A., Park, S.-J., Lee, S.-C., Park, S. W., Jang, W. J., Lee, M., Chun, W. J., Oh, J. H., Park, Y. H., Choe, Y. H., Gwon, H.-C., Hahn Tags: Magnetic Resonance Imaging (MRI), Pharmacology, Acute Coronary Syndromes Original Research Source Type: research

An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population [Arrhythmia and Electrophysiology]
ConclusionsA VCL common variant was genetically and biophysically associated with Chinese SUNDS. The aggravation of loss of function of SCN5A caused by VCL‐D841H under acidosis supports that nocturnal sleep respiratory disorders with acidosis may play a key role in the pathogenesis of SUNDS. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 3, 2017 Category: Cardiology Authors: Cheng, J., Kyle, J. W., Lang, D., Wiedmeyer, B., Guo, J., Yin, K., Huang, L., Vaidyanathan, R., Su, T., Makielski, J. C. Tags: Sudden Cardiac Death Original Research Source Type: research

An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure [Contemporary Review]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Kurtz, T. W., DiCarlo, S. E., Pravenec, M., Morris, R. C. Tags: High Blood Pressure, Hypertension Contemporary Review Source Type: research

Benefits of Permanent His Bundle Pacing Combined With Atrioventricular Node Ablation in Atrial Fibrillation Patients With Heart Failure With Both Preserved and Reduced Left Ventricular Ejection Fraction [Heart Failure]
This study evaluated clinical outcomes of permanent HBP in atrial fibrillation patients with narrow QRS who underwent atrioventricular node ablation for heart failure symptoms despite rate control by medication.Methods and ResultsThe study enrolled 52 consecutive heart failure patients who underwent attempted atrioventricular node ablation and HBP for symptomatic atrial fibrillation. Echocardiographic left ventricular ejection fraction and left ventricular end‐diastolic dimension, New York Heart Association classification and use of diuretics for heart failure were assessed during follow‐up visits after permanent HBP. ...
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Huang, W., Su, L., Wu, S., Xu, L., Xiao, F., Zhou, X., Ellenbogen, K. A. Tags: Arrhythmias, Heart Failure, Pacemaker Original Research Source Type: research