Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis
AbstractPurpose of ReviewPregnancy-induced preeclampsia is a severe pregnancy complication and preeclampsia has been associated with an increased risk of chronic hypertension for offspring. However, the magnitude of the overall effect of exposure to preeclampsia in pregnancy on blood pressure (BP) in offspring is unknown. This systematic review and meta-analysis was sought to systematically assess the effects of preeclampsia on the BP of the offspring.Recent FindingsOf 2550 publications identified, 23 studies were included. The meta-analysis indicated that preeclampsia increases the potential risk of hypertension in offspr...
Source: Current Hypertension Reports - May 23, 2024 Category: Primary Care Source Type: research

White Coat Hypertension & amp; Cardiovascular Outcomes
AbstractPurpose of ReviewThis review aims to inform the reader of the complexity of blood pressure responses when comparing blood pressure measured in the medical environment to that outside the medical environment. In addition, we summarize what is known about current predictors of white coat hypertension, reevaluate the relationship of white coat hypertension to cardiovascular outcomes, and provide some clinical guidance on management.Recent FindingsDifferences in outcomes exist when white coat effect occurs in unmedicated people versus the white coat effects in those on antihypertensive therapy.SummaryWhite coat hyperte...
Source: Current Hypertension Reports - May 18, 2024 Category: Primary Care Source Type: research

Posterior Reversible Encephalopathy Syndrome in Children and Adolescents
AbstractPurpose of ReviewPosterior reversible encephalopathy syndrome, or PRES, is a constellation of severe, acute hypertension and specific brain imaging findings. This may be caused by failure of the cerebral autoregulatory system to manage acute or severe changes in blood pressure. The incidence in children is unknown but estimated to be more common in children with predisposing factors including renal disease, autoimmune disease, malignancy, solid organ transplantation, stem cell transplantation, hypertension, sepsis, and exposure to certain medications.Recent FindingsManagement of PRES includes addressing hypertensio...
Source: Current Hypertension Reports - May 10, 2024 Category: Primary Care Source Type: research

Diet to Stop Hypertension: Should Fats be Included?
AbstractPurpose of ReviewInternational guidelines emphasize advice to incorporate dietary measures for the prevention and in the management of hypertension. Current data show that modest reductions in weight can have an impact on blood pressure. Reducing salt and marine oils have also shown consistent benefit in reducing blood pressure. Whether other dietary constituents, in particular the amount and type of fat that play important roles in cardiovascular prevention, influence blood pressure sufficiently to be included in the management of hypertension is less certain. In this review, we provide a summary of the most recen...
Source: Current Hypertension Reports - May 7, 2024 Category: Primary Care Source Type: research

Considering Adverse Effects of Common Antihypertensive Medications in the ED
AbstractPurpose of ReviewTo evaluate the adverse effects of common antihypertensive agents utilized or encountered in the Emergency Department.Recent FindingsAll categories of antihypertensive agents may manifest adverse effects, inclusive of adverse drug reactions (ADRs), drug-to-drug interactions, or accidental overdose. Adverse effects, and specifically ADRs, may be stratified into the organ systems affected, might require specific time-sensitive interventions, could pose particular risks to vulnerable populations, and may result in significant morbidity, and potential mortality.SummaryAdverse effects of common antihype...
Source: Current Hypertension Reports - April 30, 2024 Category: Primary Care Source Type: research

Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension
AbstractPurpose of the ReviewTo review what intestinal permeability is and how it is measured, and to summarise the current evidence linking altered intestinal permeability with the development of hypertension.Recent FindingsIncreased gastrointestinal permeability, directly measuredin vivo, has been demonstrated in experimental and genetic animal models of hypertension. This is consistent with the passage of microbial substances to the systemic circulation and the activation of inflammatory pathways. Evidence for increased gut permeability in human hypertension has been reliant of a handful of blood biomarkers, with no stu...
Source: Current Hypertension Reports - April 25, 2024 Category: Primary Care Source Type: research

Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure
AbstractPurpose of the ReviewPreserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the pathogenesis of preserved ejection fraction heart failure is unclear. Accumulation of visceral adiposity underlies the pathogenic aftermaths of obesity. However, visceral adiposity imaging is assessed by computed tomography or magnetic resonance and thus not routinely available. In contrast, epicardial adiposity thickness is assessed by echocardiography and thus routinely available. We review the rationale for assessing epicardial adiposity thickness in patients with preserve...
Source: Current Hypertension Reports - April 20, 2024 Category: Primary Care Source Type: research

Neuroimmunology of Cardiovascular Disease
AbstractPurpose of ReviewCardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention strategies the number of persons affected by CVD continues to rise. Thus, there is great interest in unveiling novel mechanisms that may lead to new treatments. Considering this dilemma, recent focus has turned to the neuroimmune mechanisms involved in CVD pathology leading to a deeper understanding of the brain ’s involvement in disease pathology. This review provides an overview of new and salient findings regarding the neuroimmune mechanisms that contribute to CVD.Rece...
Source: Current Hypertension Reports - April 13, 2024 Category: Primary Care Source Type: research

Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure
AbstractPurpose of ReviewHypertension is a principal risk factor for cardiovascular morbidity and mortality, with its severity exacerbated by high sodium intake, particularly in individuals with salt-sensitive blood pressure. However, the mechanisms underlying hypertension and salt sensitivity are only partly understood. Herein, we review potential interactions in hypertension pathophysiology involving the immune system, endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and proteostasis pathways; identify knowledge gaps; and discuss future directions.Recent FindingsRecent advancements by our research ...
Source: Current Hypertension Reports - April 11, 2024 Category: Primary Care Source Type: research