Evaluation of Tissue-Clearing Techniques for Intraorgan Imaging of Distribution of Polymeric Nanoparticles as Drug Carriers.
CONCLUSION: The intraorgan imaging method was established using modified CUBIC technique by the intravenous administration of fluorescence-tagged tomato lectin for evaluating the distribution of polymeric nanoparticles in mouse pigment-rich organs. PMID: 33115275 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - October 30, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development and Characterization of Orodispersible Film Containing Cefixime Trihydrate.
This study aimed to develop an orodispersible film (ODF) containing cefixime trihydrate (CFX) to cope with the above mentioned problems as well as to enhance water solubility and masking the bitter taste of the drug. The freeze-drying and kneading methods were used for the formation of inclusion complexes. The physicochemical evaluation revealed that T7 was the best film for the incorporation of pure drug and inclusion complexes. Films were further characterized for physical and mechanical properties. Drug content, dissolving time of the film and drug release test was performed. In-vivo taste and disintegration time studie...
Source: Drug Development and Industrial Pharmacy - October 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation and characterization of triamterene complex with ascorbic acid derivatives.
Authors: Onoda H, Inoue Y, Ezawa T, Murata I, Chantadee T, Limmatvapirat S, Oguchi T, Kanamoto I Abstract The purpose of this study was to prepare solid dispersions of triamterene (TRT) with ascorbic acid (AA) or ascorbic acid 2 glucoside (AA2G) and to evaluate their physical properties. Solid dispersions were prepared by dissolving each sample in an organic solvent and evaporation (EVP). Powder X-ray diffraction (PXRD) revealed a halo pattern for EVP1 (AA/TRT =1/1) and EVP2 (AA2G/TRT =1/1). In differential scanning calorimetry (DSC), endothermic peaks due to the melting of TRT and AA disappeared for EVP1 (AA/TRT =...
Source: Drug Development and Industrial Pharmacy - October 28, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation, characterization and pharmacodynamic study on deep second degree burns of total flavonoids composite phospholipids liposome of Oxytropis falcata Bunge.
Authors: Zeng Q, Cai X, Cao Y, Zhou C, Yu L, Chen J Abstract OBJECTIVE: To further rsearch the biological activity of total flavonoids of Oxytropis falcata Bunge on deep second degree (II°) burns by liposome gel and to elucidate its underlying mechanism. METHODS: The total flavonoids composite phospholipids liposome of Oxytropis falcata Bunge (TFOFB-CPL) was synthesized by thin-film dispersion method and the preparation process was optimized via central composite design. The TFOFB-CPL was then characterized by using particle size, polydispersity indexes (PDIs), zeta potential, encapsulation efficiency (EE) ...
Source: Drug Development and Industrial Pharmacy - October 25, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation and Optimization of Multi-Functional Directly Compressible Excipient: An Integrated Approach Of Principal Component Analysis And Design Of Experiments.
Authors: Mori D, Rathod P, Parmar R, Dudhat K, Chavda J Abstract Developing a new excipient and obtaining its market approval is an expensive, time-consuming, and complex process. The application of multivariate analytical approach - principal component analysis (PCA) in combination with DoE approach can make the process of developing co-processed excipient cost-effective and rapid. The present investigation was aimed to demonstrate the applicability of the DoE approach and PCA in developing a co-processed excipient by using spray drying technique. The preliminary studies suggested a significant effect of inlet air...
Source: Drug Development and Industrial Pharmacy - October 25, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Chemical composition and pharmacological mechanism of Shenfu decoction in the treatment of novel coronavirus Pneumonia (COVID-19).
This study aimed to explore the material basis and molecular mechanism of Shenfu Decoction through network pharmacology and molecular mechanisms, to provide a research basis for clinical medication and clues for subsequent research. METHODS: The active components and targets of Shenfu decoction were searched in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the COVID-19-associated genes were collected using the GeneCards platform. The target protein-protein interaction network map was constructed by mapping two genes, and the "drug-active ingredient-target" n...
Source: Drug Development and Industrial Pharmacy - October 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Design, Fabrication & Characterization of Graft Co-Polymer Assisted Ocular Insert: A State of Art in Reducing Post-Operative Pain.
Conclusion: It was concluded that the ocular inserts of the poorly soluble nepafenac developed using a graft-co-polymer enhanced the solubility and utilization of the drug for a prolonged period. Highlights:The use of graft Co-Polymer enhanced the solubility of Nepafenac and assisted in the design of ocular insert formulation.The problem of less contact time associated with eye drops is overcome by the novel formulation of Insert.The formulation remains in contact for longer period of time and hence provide enhanced duration of action and maximum drug utilization.It is biocompatible & bio erodible in nature. PMID: ...
Source: Drug Development and Industrial Pharmacy - October 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Fabrication and evaluation of fast disintegrating pellets of cilostazol.
Authors: Arora U, Thakkar V, Baldaniya L, Gohel MC Abstract The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was achieved by preparing inclusion complex with Captisol® (Sulfobutyl Ether β cyclodextrin - SBE-β-CD). Extrusion-spheronization technique was used to formulate pellets. Placket-Burman design was used for the initial screening of most significant factors suc...
Source: Drug Development and Industrial Pharmacy - October 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Pre-plasticization of thermal binder facilitates processing and granule growth during melt granulation of gabapentin using co-rotating twin screw extruder.
Authors: Spahn J, Zhang F Abstract Plasticization, a common method of reducing the polymer melt viscosity in plastics extrusion, was investigated to improve the processability of a pharmaceutical formulation during twin-screw melt granulation. The thermolabile drug gabapentin was used as a model compound given previous work showed the benefit of preparing 80% drug loading gabapentin granules with hydroxypropyl cellulose as thermal binder. The plasticizer triethyl citrate was selected based on physicochemical compatibility with both the thermal binder and gabapentin by assessing polymer melt rheology and drug stabil...
Source: Drug Development and Industrial Pharmacy - October 7, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Investigation of the mucoadhesivity, swelling and drug release mechanisms of indomethacin buccal tablets: effect of formulation variables.
Authors: Esim O, Savaser A, Ozkan CK, Tas C, Ozkan Y Abstract The purpose of this study was to investigate the effect of formulation variables on properties related to critical functionality for their use in indomethacin buccal tablets. Chitosan (CH), carbopol (PAA) and hydroxypropyl methyl cellulose (HPMC) concentration and filler type were evaluated as parameters for describing tablet hardness, swelling index, indomethacin release and mucoadhesion in controlled release buccal tablets. Moreover, a 32 full factorial design was employed to study the effect of each polymer ratios in CH and PAA combination, which sign...
Source: Drug Development and Industrial Pharmacy - October 3, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.
CONCLUSIONS: The results of this study suggest that Carbopol 971P NF was the most appropriate polymer for a probiotic mucoadhesive ODT. PMID: 33006298 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - October 3, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Panax quinquefolium saponin liposomes prepared by passive drug loading for improving intestinal absorption.
In this study, PQS liposomes (PQS-Lips) were prepared by thin layer hydration, an in situ single-pass intestinal perfusion (SPIP) model was used to verify the improvement of membrane permeability of PQS-Lips. PQS-Lips had a high encapsulation efficiency (EE) of 65%∼70%, a particle size about 100.0 nm, and a zeta potential of -60 mV with regular spherical surface. FTIR and DSC showed the PQS in liposomes were amorphous, indicating that hydrogen bonds formed between one or several hydroxyl groups in PQS and C-O group at the phospholipid polar terminal. In addition, PQS-Lips showed sustained release in ...
Source: Drug Development and Industrial Pharmacy - October 1, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

New resveratrol micelle formulation for ocular delivery: characterization and in vitro/in vivo evaluation.
Authors: Li M, Zhang L, Li R, Yan M Abstract Many eye diseases, such as corneal wound healing after injury, involve oxidative stress and inflammatory responses; however, many efficient natural antioxidants (e.g., resveratrol) have limited application in ophthalmology due to their poor solubility, low stability and poor ocular bioavailability. In this work, the aim was to formulate resveratrol into a micelle ophthalmic solution for efficient delivery to the eye. A Soluplus micelle ophthalmic solution containing resveratrol (Sol-Res) was formulated and optimized with a small and uniform dispersion in an ophthalmic so...
Source: Drug Development and Industrial Pharmacy - September 30, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation, Evaluation and In vitro Cytotoxicity Studies of Artesunate-loaded Glycyrrhetinic Acid Decorated PEG-PLGA Nanoparticles.
The objective of this study was to prepare the liver targeting drug delivery system (TDDS) of artesunate (ART)-loaded polyethylene glycol (PEG)-Poly (D, L-lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) modified by glycyrrhetinic acid (GA), and evaluate its in vitro cytotoxicity.Significance: The GA-PEG-PLGA-ART NPs enhanced the in vitro cytotoxicity on HCC cell lines. The development of GA-PEG-PLGA NPs will greatly push the clinical applications of ART as a novel anticancer drug.Methods: The NPs were prepared using solvent evaporation method, and the formulation was optimized through an orthogonal design. In addition,...
Source: Drug Development and Industrial Pharmacy - September 27, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Enhanced oral bioavailability of self-Assembling curcumin-vitamin E prodrug-nanoparticles by co-nanoprecipitation with Vitamin E TPGS.
In this study, a novel prodrug-nanoparticles (CSSV/TPGS-NPs) self-assembled by co-nanoprecipitation of curcumin-s-s-vitamin E conjugate and D-alpha-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) was prepared in attempt to solve aforementioned obstacles. CSSV/TPGS-NPs showed smaller sizes and better stability compared with that of curcumin-s-s-vitamin E conjugate prodrug-nanoparticles (CSSV-NPs). Significantly, the absorption constant and effective permeability of CSSV/TPGS-NPs in different intestinal tracts increased 1.31-2.78 times and 1.81-6.95 times than that of CUR suspension, respectively. Pharmacokine...
Source: Drug Development and Industrial Pharmacy - September 26, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Statistical development and in vivo evaluation of resveratrol loaded topical gel containing deformable vesicles for a significant reduction in photoinduced skin aging and oxidative stress.
Conclusion: Restoration of first-line defense mechanism in chronic UV exposed animal model has proved that transethosomal resveratrol can be developed as an innovative cosmetic product for significant improvement and repair of photo-aged skin. PMID: 32962434 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 24, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Eu(III)-coordination polymer: inhibitory activity on cervical cancer via inducing ROS mediated apoptosis.
Authors: Hong D, Zhao HM Abstract Under the hydrothermal reaction condition, we prepared a new 3D Eu(III)-based coordination polymer (CP) [Eu(H2-DHBDC)0.5(DHBDC)0.5 (H2O)2]n·H2O (1, H4-DHBDC = 2,5-dihydroxy-1,4-terephthalic acid). Furthermore, we assessed the inhibitory influence on cervical cancer cells of this compound. Firstly, for testing the anti-viability of the compound against cervical cancer cells, the Cell Counting Kit-8 (CCK-8) assay was carried out. Then reactive oxygen species (ROS) detection kit was used to determine the ROS accumulation in the cervical cancer cells. Finally, after the Annexin ...
Source: Drug Development and Industrial Pharmacy - September 24, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

A Novel α-(8-quinolinyloxy) Monosubstituted Zinc Phthalocyanine Nanosuspension for Potential Enhanced Photodynamic Therapy.
Conclusion: The ZnPc-NS exhibited optimal stability, faster photosensitization rate of 1O2, and optimal antitumor activity and safety than the ZnPc DMF solution, which could provide potential support for further research and development. PMID: 32951478 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 23, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Application of HPMC HME polymer as hot melt extrusion carrier in carbamazepine solid dispersion.
Conclusion: HPMC HME 15LV, as a new HME carrier, has certain advantages in producing well CBZ-SD preparation. Its low viscosity can prevent the gelatinization phenomenon during capsule dissolution, as well as suitable Tg and low hygroscopicity were also benefit to the stability of CBZ-SD. PMID: 32942902 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.
Conclusions: Aerosolized drug delivery systems using PEGylated liposomes exhibited prolonged distribution in both healthy and fibrotic mouse lungs. PEGylated liposomes were determined to be efficient drug delivery systems for anti-fibrotic agents targeting lung fibroblasts and alveolar epithelial cells for optimizing the treatment of IPF. PMID: 32940095 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 19, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

An examination of carbopol hydrogel/organogel bigels of thymoquinone prepared by microwave irradiation method.
Authors: Algin Yapar E, Tuncay Tanriverdi S, Aybar Tural G, Gümüş ZP, Turunç E, Gokce EH Abstract Nigella sativa L. is shown wide spread over the world and contains many useful phytochemicals. Much of the biological activity of the seeds has been shown due to the presence of thymoquinone (TQ). Its poor aqueous solubility of TQ hinders its delivery to target site. The aim of this work was to prepare TQ bigels composed of Carbopol 974 P NF (C974) in PEG 400 (organogel) or C974 in water (hydrogel) with microwave heating method. A novel technique, high speed homogenization followed by microwave...
Source: Drug Development and Industrial Pharmacy - September 17, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

The pH-triggered polyglutamate brush co-delivery of MDR1 and survivin-targeting siRNAs efficiently overcomes multi-drug resistance of NSCLC.
In this study, we attempted to overcome MDR of NSCLC by simultaneously interfering with two RNAs that have different functions. A new pH-triggered polyglutamate brush polymer dimethylmaleic anhydride-poly(ethyleneglycol) monomethyl ether-b-polyglutamate-g-spermine (DMA-mPEG-b-PG-g-spermine, DPPGS) was designed and synthesized. The DPPGS/small interfering RNA (siRNA) complex nanoparticles (DPPGSN) were prepared. The results demonstrated that DPPGSN could be transformed from a negatively charged form into a positively charged form in the slightly acidic tumor extracellular environment. The siRNA targeting MDR1 mRNA (siMDR1) ...
Source: Drug Development and Industrial Pharmacy - September 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Comparison of Media Milling and Microfluidization Methods for Engineering of Nanocrystals: A Case Study.
Conclusions: Based on the characterization outcomes, it can be concluded that both the top-down technologies could be successfully applied to develop nanocrystals of poorly water-soluble drugs. However, microfluidization was found to outplay media milling in terms of processing time and drug loading. PMID: 32912040 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 13, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Visualized analysis and evaluation of simultaneous controlled release of Metformin Hydrochloride and Gliclazide from sandwiched osmotic pump capsule.
Authors: Gao S, Chen Y, Hu R, Lu W, Yu L, Chen J, Liu S, Guo Y, Shen Q, Wang B, Fang W Abstract The aim of this study was to develop the Metformin Hydrochloride and Gliclazide (MH-GZ) sandwiched osmotic pump capsule which could overcome the problems associated with short half-life and burst release. The system could deliver drugs with different solubility simultaneously at zero-order rate, in which MH-GZ were filled in both sides of the push layer respectively. The single factor and orthogonal test were employed to obtain the optimized formulation with the evaluation index of similarity factor (ƒ2). R language...
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Optimization and In vivo Evaluation of Quetiapine Loaded Transdermal Drug Delivery System for the Treatment of Schizophrenia.
Authors: Agrawal MB, Patel MM Abstract The prevailing studies were carried out to formulate and optimize the quetiapine transdermal matrix patch by the usage of Box-Behnken design for ameliorated bioavailability when contrasted with conventional drug delivery. The Box-Behnken design with 3-level and 3-factor was utilized to explore the intermingle impact of critical attributes on tensile strength, in vitro drug release, and flux. Optimized formulation was characterized for Fourier transform infrared, differential scanning calorimetry, in-vivo pharmacokinetics, and skin irritation along with stability studies. The i...
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Levofloxacin-loaded Naturally Occurring Monoterpene-based Nanoemulgel: A Feasible Efficient System to Circumvent MRSA Ocular Infections.
In conclusion, the current investigation provided a strong foundation for further studies of limonene nanoemulgel as a potential complementary therapeutic agent against resistant bacterial strains. PMID: 32896171 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

A novel multi-stimuli-responsive theranostic nanomedicine based on Fe3O4@Au nanoparticles against cancer.
Authors: Massoumi B, Farnudiyan-Habibi A, Derakhshankhah H, Samadian H, Jahanban-Esfahlan R, Jaymand M Abstract A novel multi-stimuli-responsive theranostic nanomedicine was designed and fabricated by the conjugation of a thiol end-capped poly(N-isopropylacrylamide-block-acrylic acid) (HS-PNIPAAm-b-PAA) onto Fe3O4@Au nanoparticles (NPs) followed by physical loading of doxorubicin hydrochloride (Dox) as a general anti-cancer drug. For this purpose, Fe3O4@Au NPs were fabricated through small Au nanolayer grown on larger magnetic NPs. A HS-PNIPAAm-b-PAA was synthesized through an atom transfer radical polymerization (...
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Bridging the Gap: Academia, Industry and FDA Convergence for Nanomaterials.
Authors: Shah S, Nene S, Rangaraj N, Raghuvanshi RS, Singh SB, Srivastava S Abstract Nano-medicine is the fastest growing field in pharmaceutical industry today. However, there still exist several hurdles preceding its clinical translation. This review provides insights on the guidelines for nanomaterials provided by the US-FDA (United States Food and Drug Administration), various approval pathways and also addresses the lacunae between academic research, pharmaceutical industry and US-FDA through an attempt to overcome the hurdle to its clinical translation. We have also emphasized various ways to overcome the des...
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development of Polymeric Nanoparticle Gel Prepared with the Combination of Ionic Pre-Gelation and Polyelectrolyte Complexation as a Novel Drug Delivery of Timolol Maleate.
Conclusion: The prepared nanoparticle gel can be an effective controlled release system of TM that administered topically on the skin surface. PMID: 32901561 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation and characterization of polypills containing aspirin and simvastatin using 3D printing technology for the prevention of cardiovascular diseases.
Authors: Keikhosravi N, Mirdamadian SZ, Varshosaz J, Taheri A Abstract Three-dimensional printing has become a promising manufacturing technique for pharmaceutical products. Fused Deposition Modeling (FDM) is the most affordable printing technology. But this technique has two major drawbacks: limited drug loading capacity and the stability of thermolabile drugs. So, other techniques such as melt casting could be associated with FDM to overcome these limitations. In the melt casting method, drug is mixed with a molten polymer and is poured in the mold and allowed to solidify. The present paper for the first time des...
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development of arsenic trioxide sustained-release pellets for reducing toxicity and improving compliance.
Authors: Liu X, Zhou P, Yang Y, Liu J, Widjaya AS, Jiang Y Abstract Arsenic trioxide (ATO) is first-line drug for acute promyelocytic leukemia. Clinically, the continuously slow intravenous infusion is adopted to maintain effective blood concentration and reduce toxic effects, but it causes poor patient' compliance for a considerable infusion period. To overcome these disadvantages, we developed an oral ATO sustained-release preparation which were constructed via the ATO core pellets prepared by extrusion spheronization and followed by a coating membrane by fluid-bed technology. The prepared coated pellets displaye...
Source: Drug Development and Industrial Pharmacy - September 10, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

In vitro and in vivo amelioration of colitis using targeted delivery system of cyclosporine A in NewZealand rabbits.
In conclusion, all in vitro and in vivo results confirm the successful site specific delivery and anti inflammatory efficacy of developed formulation of Cyp A in TNBS induced colitis in NewZealand rabbits. PMID: 32892648 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Intranasal delivery of a nicotine vaccine candidate induces antibodies in mouse blood and lung mucosal secretions that specifically neutralize nicotine.
Conclusion: Intranasal immunization with a nicotine vaccine candidate can induce systemic and mucosal antibodies that specifically neutralize nicotine. PMID: 32892651 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Diclofenac Diethylamine Nanosystems-Loaded Bigels for Topical Delivery: Development, Rheological Characterization, and Release Studies.
The objective of this study was to develop novel topical drug delivery systems of the nonsteroidal anti-inflammatory drug diclofenac diethylamine (DDEA). Toward this objective, DDEA was loaded into two nanosystems, the oil in water (O/W) nanoemulsion (DDEA-NE) and the gold nanorods (GNR) that were conjugated to DDEA, forming DDEA-GNR. The DDEA-NE and DDEA-GNR were characterized in terms of particle size, zeta potential, morphology, thermodynamic stability, DDEA loading efficiency, and UV-Vis spectroscopy. These nanosystems were then incorporated into the biphasic gel-based formulations (bigels) for topical delivery. The rh...
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Co-processing of nateglinide with meglumine for enhanced dissolution rate: In vitro and in vivo evaluation.
Conclusion: Dry co-grinding of nateglinide with meglumine developed new species which liberated nateglinide rapidly and enhanced the rate and extent of hypoglycemia of nateglinide. PMID: 32892654 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

A Bioequivalence Study of Two Telmisartan 80  mg Tablets in Healthy Indonesian Subjects: An Open Label, Three-way, Three-period, Partial Replicate Crossover Study.
This study aimed to compare the bioavailability of two 80 mg telmisartan tablets in healthy Indonesian subjects. A randomized, open-label, single-dose, three-sequence, three-way, reference-formulation-replicated crossover study was conducted under fasting period with two-week washout period. In this study, thirty-one Indonesian subjects were enrolled and twenty-eight subjects were completed the study. Serial blood samples were collected up to 72 hours following drug administration. Plasma concentrations of telmisartan were determined using high performance liquid chromatography method with fluorescence detect...
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Synergistic Effect of Self-assembled Curcumin-Piperine-Loaded Human Serum Albumin Nanoparticles on Suppressing Cancer Cells.
Conclusions: The results suggest that CUR-PIP-HSA-NPs can be employed as a practical drug delivery system in cancer treatment with synergistic effects of both CUR and PIP. PMID: 32892656 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development and Evaluation of Polymeric Micelle Containing Tablet Formulation for Poorly Water Soluble Drug: Tamoxifen Citrate.
In this study poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) triblock copolymer, which has been approved by FDA for oral application was used to benefit its micellar solubilization effect. Self-assembled micelles were prepared for the delivery of TMX and this way TMX solubility was increased approximately 60 times. TMX treated cells showed 38.06 ± 1.5% viability at 50 μM concentration for 24h; 66.71 ± 11.6% viability at 25 μM concentration for 48h, at the same conditions TMX loaded micelles exhibited 24.994 ± ...
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Vision of bacterial ghosts as drug carriers mandates accepting the effect of cell membrane on drug loading.
In this study, Escherichia coli (E. coli) BGs were prepared using modified protocol sponge-like reduced protocol (SLRP) which was used for loading of doxorubicin (DOX). First time in the literature, different possible factors affecting DOX loading from BGs were examined in this study. These factors including drug concentration, temperature, pH gradient, incubation time and tonicity, are proposed to effect on drug loading into E. coli BGs. Results of optimum effect from accompanied factors were found to be 10 mg/ml as DOX concentration at pH 6 with tonicity of 0.7% incubated overnight at 4 °C. After gather...
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Validated Specific HPLC-DAD Method for Simultaneous Estimation of Paracetamol and Chlorzoxazone in Presence of Five of Their Degradation Products and Toxic Impurities.
Authors: El-Yazbi AF, Guirguis KM, Bedair MM, Belal TS Abstract This work demonstrates a specific and reliable HPLC with diode array detection (DAD) method for the simultaneous estimation of paracetamol (PAR) and chlorzoxazone (CZ) in presence of five of their degradation products and toxic impurities; namely; 4-aminophenol (AP), 4-nitrophenol (NP), acetanilide (AT), 4-chloroacetanilide (CA) and 2-amino-4-chlorophenol (ACP). Successful chromatographic separation was accomplished using Waters Symmetry C8 column (3.9 × 150 mm, 5 μm) with gradient elution of the mobile phase consis...
Source: Drug Development and Industrial Pharmacy - September 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Correction.
Authors: PMID: 32870123 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - September 3, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

The relationship between the Hammett acidity and the decomposition of cefotaxime sodium in the solid state.
Authors: Al-Tanni BM, Alkhamis KA, Abu Baker S, Haddad R Abstract It was of interest to correlate the solid state acidity to the decomposition of a model drug namely cefotaxime sodium. Amorphous samples containing either an indicator probe (thymol blue) or a model drug (cefotaxime sodium) were prepared by freeze drying. The prepared samples were characterized using XRPD and Karl Fischer titrimetry. The acidity in the solid state was measured using reflectance spectroscopy. The kinetics of hydrolysis of cefotaxime sodium was studied in solid state at 50˚C in the Hammett acidity range of 8.12-8.61 and at constant io...
Source: Drug Development and Industrial Pharmacy - August 27, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract/potassium oxonate-induced hyperuricemic mice.
Conclusion: Taken together, Sco-Ms represent a potential oral strategy for the treatment of hyperuricemia. PMID: 32811191 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - August 21, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Improved hepatoprotective activity of Beta vulgaris L. leaf extract loaded self-nanoemulsifying drug delivery system (SNEDDS): In vitro and in vivo evaluation.
The objective of the current study is the development and optimization of self-nanoemulsifying drug delivery systems (SNEDDSs) to enhance the hepatoprotective activity of beet leaf (BL) extract.Methods: Total flavonoids content was estimated in the BL extract and its solubility was evaluated in various vehicles to select proper component combinations. Pseudo-ternary phase diagrams were constructed employing olive, linseed, castor and sesame oils (oil phase), Tween® 20 (Tw20) and Tween® 80 (Tw80) (surfactants) as well as dimethyl sulfoxide (DMSO) and propylene glycol (PG) (co-surfactants). Optimization of formulatio...
Source: Drug Development and Industrial Pharmacy - August 21, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development and characterization of Chitosan Nanoparticles Containing an Indanonic Tricyclic Spiroisoxazoline Derivative using Ion-gelation Method: An in vitro study.
The objectives of this work are first, investigating the impact of two important parameters (i.e. chitosan or sodium tripolyphosphate (TPP) solution concentration and chitosan to TPP mass ratio) on the chitosan nanoparticles (CNPs) formation by ionic-gelation method and then, the synthesis and characterization of chitosan-based, biodegradable drug-loaded nanoparticles in the encapsulation of novel 4'-(4-(methylsulfonyl)phenyl)-3'-(3,4,5-trimethoxyphenyl)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one (MTS) indanonic tricyclic spiroisoxazoline, which is a potent anticancer drug. The particle size, shape, zeta potential, drug loa...
Source: Drug Development and Industrial Pharmacy - August 21, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Optimization of lipid materials in the formulation of S-carvedilol self-microemulsifying drug-delivery systems.
Conclusions The SMEDDS using ionic lipids (oleic acid or soybean lecithin) as oil phase can increase the oral bioavailability of S-CAR by increasing the solubility and reducing the first-pass effect. PMID: 32806972 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - August 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Turmeric/Oregano Formulations for Treatment of Diabetic Ulcer Wounds.
Authors: Sami DG, Abdellatif A, Azzazy HME Abstract Diabetic wound infections and pressure ulcers pose a significant challenge to healthcare providers worldwide. The current study provides new and innovative wound care products that reduce inflammation, clear infection and improve healing in an animal model of pressure ulcers in diabetic rats. Ointment, hydrogel, and nanofiber dressings were synthesized using 5% turmeric, 1% oregano, and 1% chitosan nanoparticles and tested for antibacterial and cytotoxicity in vitro, and wound healing effects in vivo.Turmeric ethanolic extract showed high antioxidant activity comp...
Source: Drug Development and Industrial Pharmacy - August 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Formulation of Curcumin - β cyclodextrin - Polyvinylpyrrolidone supramolecular inclusion complex: Experimental, molecular docking and preclinical anti-nociceptive assessment.
Formulation of Curcumin - β cyclodextrin - Polyvinylpyrrolidone supramolecular inclusion complex: Experimental, molecular docking and preclinical anti-nociceptive assessment. Drug Dev Ind Pharm. 2020 Aug 18;:1-31 Authors: Jafar M, Khalid MS, Eid Al Dossari MF, Amir M, Alshaer FI, Adrees FAA, Gilani SJ, Alshehri S, Hassan MZ, Imam SS Abstract The current research planned to ameliorate an aqueous solubility and dissolution of curcumin (CUR) by the formulation of inclusion complex with β-cyclodextrin and polyvinyl pyrrolidone. The phase solubility study was performed to assess the solubility of ...
Source: Drug Development and Industrial Pharmacy - August 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

A Sustainable UPLC-UV Method for Quantification of Donepezil Hydrochloride in Biorelevant Media Applied to Dissolution Profile Comparison.
Authors: Campos DP, Silva-Barcellos NM, Marinho FDM, Barbosa GX, Lana VLVV, de Souza J Abstract Donepezil hydrochloride is one of the most prescribed anti-Alzheimer's drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions in vivo (pH 1.2, 4.5, 6.8) are not available in the literature. These media are used in the dissolution test, an important tool, for registration and quality control of medicines. Considering the need for methods with this purpose, this work aimed to develop and validate a sus...
Source: Drug Development and Industrial Pharmacy - August 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preliminary in vitro and in vivo evaluation of specific activity of branched oligohexamethyleneguanidine hydrochloride.
This study aimed at evaluating antimicrobial activity of OHMG against potential causative agents of oral and pharyngeal mucosa infections, specifically, the activity against 56 clinical strains, 5 of which were antibiotics-resistant. Also, a preliminary in vivo study of specific activity of OHMG based on a traumatic stomatitis and gingivitis model in rabbits was carried out. In vitro antimicrobial activity of OHMG was determined by testing the minimal inhibitory concentration (MIC). OHMG displayed excellent activity against Streptococcus pneumoniae, Streptococcus pyogenes (MIC was 0.002-0.25 μg/ml), Moraxella catarrhali...
Source: Drug Development and Industrial Pharmacy - August 20, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research