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Eutectic solutions for healing: a comprehensive review on therapeutic deep eutectic solvents (TheDES)
Drug Dev Ind Pharm. 2024 Apr 24:1-14. doi: 10.1080/03639045.2024.2345131. Online ahead of print.ABSTRACTOBJECTIVE: TheDES are formed by mixing a Hydrogen Bond Donor (HBD) and a Hydrogen Bond Acceptor (HBA) in appropriate molar ratios. These solvents have been shown to enhance drug solubility, permeability, and delivery. The main objective of the present article is to review these advantages of TheDES.SIGNIFICANCE: TheDES show unique properties, such as low toxicity, biodegradability, improved bioavailability and enhanced drug delivery of poorly soluble active pharmaceutical ingredients. They are also biocompatible in natur...
Source: Drug Development and Industrial Pharmacy - April 18, 2024 Category: Drugs & Pharmacology Authors: Sudhanshu Kalantri Amisha Vora Source Type: research

Eutectic Solutions for Healing: A Comprehensive Review on Therapeutic Deep Eutectic Solvents (TheDES)
Drug Dev Ind Pharm. 2024 Apr 18:1-38. doi: 10.1080/03639045.2024.2345131. Online ahead of print.ABSTRACTObjective TheDES are formed by mixing a Hydrogen Bond Donor (HBD) and a Hydrogen Bond Acceptor (HBA) in appropriate molar ratios. These solvents have been shown to enhance drug solubility, permeability, and delivery. The main objective of the present article is to review these advantages of TheDES.SIGNIFICANCE: TheDES show unique properties, such as low toxicity, biodegradability, improved bioavailability and enhanced drug delivery of poorly soluble active pharmaceutical ingredients. They are also biocompatible in nature...
Source: Drug Development and Industrial Pharmacy - April 18, 2024 Category: Drugs & Pharmacology Authors: Sudhanshu Kalantri Amisha Vora Source Type: research

Design, optimization and pharmaceutical characterization of wound healing film dressings with chloramphenicol and ibuprofen
CONCLUSIONS: The QbD approach was successfully implemented to develop and optimize a novel film dressing promising for the treatment of low-exuding acute wounds prone to infection and inflammation.PMID:38622817 | DOI:10.1080/03639045.2024.2339306 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2024 Category: Drugs & Pharmacology Authors: Ioana Savencu Sonia Iurian C ătălina Bogdan Nicoleta Sp înu Maria Suciu Anca Pop Alexandru Țoc Ioan Tomu ță Source Type: research

Silibinin Solubilization: Combined Effect of Co-solvency and Inclusion Complex Formation
Conclusion: SLB solubility in a buffered solution supplemented by ethanol co-solvent and HP-β-CD complexing agent is a function of free drug present in the semi-aqueous media, the drug-ligand binary complex, and the drug/ligand/co-solvent ternary complex.PMID:38625641 | DOI:10.1080/03639045.2024.2343016 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2024 Category: Drugs & Pharmacology Authors: Azam Dehghan Saeed Ghanbarzadeh Majid Ghiass Mohammad Imani Source Type: research

Ferulic acid nanoemulsion as a promising anti-ulcer tool: in vitro and in vivo assessment
CONCLUSION: Findings suggest that the prepared ferulic acid nanoemulsion is an ideal anti-ulcer system, which is worthy of further investigations.PMID:38602337 | DOI:10.1080/03639045.2024.2341786 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 11, 2024 Category: Drugs & Pharmacology Authors: Hend Abd-Allah Gehad A Abdel Jaleel Azza Hassan Mevidette El Madani Maha Nasr Source Type: research

Ferulic acid nanoemulsion as a promising anti-ulcer tool: In vitro and in vivo assessment
Conclusion: Findings suggest that the prepared ferulic acid nanoemulsion is an ideal anti-ulcer system, which is worthy of further investigations.PMID:38602337 | DOI:10.1080/03639045.2024.2341786 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 11, 2024 Category: Drugs & Pharmacology Authors: Hend Abd-Allah Gehad A Abdel Jaleel Azza Hassan Mevidette El Madani Maha Nasr Source Type: research

< em > In vitro < /em > evaluation of physicochemical-dependent effects of polymeric nanoparticles on their cellular uptake and co-localization using pulmonary calu-3 cell lines
CONCLUSION: PG and PL NPs had shown no or low harmful effects on the barrier integrity, and with effective internalization and vesicular transport, thus, prospectively can be designed for pulmonary delivery applications.PMID:38533688 | DOI:10.1080/03639045.2024.2332889 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - March 27, 2024 Category: Drugs & Pharmacology Authors: Nashwa Osman Paul Curley Helen Box Neill Liptrott Darren Sexton Imran Saleem Source Type: research