Synthesis and characterization of meloxicam eutectics with mandelic acid and saccharin for enhanced solubility.
Authors: Fernandes RP, de Carvalho ACS, Ekawa B, do Nascimento ALSC, Pironi AM, Chorilli M, Caires FJ Abstract Meloxicam (MLX) is a non-steroidal anti-inflammatory which is practically insoluble in water, requiring high concentrations to reach therapeutic levels and causing frequently gastrointestinal effects. In this way, the aim of this study was to synthesize two eutectic mixtures of MLX with mandelic acid (MND) and saccharin (SAC) by liquid-assisted grinding resulting in a multicomponent material with enhanced solubility. Mixtures were studied in different stoichiometric and eutectic point was found for each eu...
Source: Drug Development and Industrial Pharmacy - June 2, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Hydroxyapatite as a biomaterial - a gift that keeps on giving.
Authors: Ghiasi B, Sefidbakht Y, Mozaffari-Jovin S, Gharehcheloo B, Mehrarya M, Khodadadi A, Rezaei M, Ranaei Siadat SO, Uskoković V Abstract The synthetic analogue to biogenic apatite, hydroxyapatite (HA) has a number of physicochemical properties that make it an attractive candidate for diagnosis, treatment of disease and augmentation of biological tissues. Here we describe some of the recent studies on HA, which may provide bases for a number of new medical applications. The content of this review is divided to different medical application modes utilizing HA, including tissue engineering, medical implants, con...
Source: Drug Development and Industrial Pharmacy - June 2, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Novel approaches to cancer therapy with ibuprofen loaded Eudragit RS 100 and/or octadecylamine modified PLGA nanoparticles by assessment of their effects on apoptosis.
Conclusion: E coded NP is selected as a promising candidate with its highly specific affinity for human lung adenocarcinoma cells and could induce cell death effectively and be a potent system to treat lung cancer. PMID: 32476502 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - June 2, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Long-term stability of insulin glulisine loaded nanoparticles formulated using an amphiphilic cyclodextrin and designed for intestinal delivery.
Authors: Presas E, Sultan E, Gervasi V, Crean AM, Werner U, Bazile D, O'Driscoll CM Abstract Long-term stability is one of the main challenges for translation of therapeutic proteins into commercially viable biopharmaceutical products. During processing and storage proteins are susceptible to denaturation. The aim of this work was to evaluate the stability of amphiphilic cyclodextrin-based nanoparticles (NPs) containing insulin glulisine. The stability of the NP dispersion was systematically evaluated following storage at three different temperatures (4 °C, room temperature (RT) and 40 °C). Wh...
Source: Drug Development and Industrial Pharmacy - June 2, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation of Technetium-99m labeled ibuprofen by direct route and Technetium-99m tricarbonyl route: A comparison of in vivo behaviors.
Authors: Durkan K, Ichedef C, Yurt Kılcar A, Arıcı M, Ucar E Abstract In the current study, ibuprofen (ibu) which is a non-steroidal anti-inflammatory drug (NSAID) was radiolabeled with 99mTc using two different methods: stannous chloride method (direct route) and technetium-99m tricarbonyl [99mTc(CO)3]+ route. Thus, it's aimed to investigate the radiolabeling potential of ibu for inflammation detection and to monitor if there is any difference in in vivo distribution depending on the radiolabeling route. Quality control studies of both radiolabeled ibu were performed by radiochromatographic methods (Thin Layer ...
Source: Drug Development and Industrial Pharmacy - June 2, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Microneedle ocular patch: fabrication, characterization and ex-vivo evaluation using pilocarpine as model drug.
The objective of the study was to design, fabricate, and investigate the effectiveness of microneedle ocular patch (MOP) in delivering the model drug, pilocarpine HCl across the corneal membrane.Methods: MOP mimicked commercially available contact lens design elements having a diameter of 14.20 mm and a sagittal height of 3.85 mm with a convex curvature. The base of this patch contained an array of 25 pyramid-shaped microneedles measuring 521 ± 10 µm in length. Pilocarpine loaded MOP was prepared by micromolding technique using dissolvable polyvinyl alcohol and polyvinyl pyrrolidone...
Source: Drug Development and Industrial Pharmacy - May 31, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Amorphous Nano Morin Outperforms Native Molecule in Anticancer Activity and Oral Bioavailability.
In this study, we have used morin hydrate (MH), a flavonol, and developed MH nanosuspension formulation (MHNS) to improve its poor physiochemical properties and low oral bioavailability. Different stabilizers with varying concentrations were investigated for preparing nanosuspension. MHNS was characterized by DLS, TEM, FTIR, DSC, powder XRD and was evaluated for its solubility, dissolution, partition coefficient, in-vitro anticancer activity and pharmacokinetics in rats. The optimized nanosuspension formulation, with a size of
Source: Drug Development and Industrial Pharmacy - May 31, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Formulation of pluronic F127/TPGS mixed micelles to improve the oral absorption of Glycyrrhizic acid.
Conclusion: These results suggested F127/TPGS-MMs might be a potential nanocarrier for oral delivery of GL. PMID: 32463722 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Impact of cyclodextrin derivatives on systemic release of duloxetine HCl via buccal route.
Conclusion: Both cyclodextrin derivatives are able to enhance drug release and permeation in vitro and ex vivo. PMID: 32420753 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 19, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Carbamazepine and levetiracetam-loaded PLGA nanoparticles prepared by nanoprecipitation method: in vitro and in vivo studies.
Conclusions: Our results showed that a decrease in seizure scores in the group treated with CBZ + LEV was observed and also, CBZ + LEV and CBZ + LEV-PLGA-NPs had similar antiepileptic activity. The NPs containing CBZ + LEV might be beneficial in the treatment of epilepsy. PMID: 32406290 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Electrospun Metronidazole-Loaded Nanofibers for Vaginal Drug Delivery.
CONCLUSIONS: Vaginal use of MET loaded nanofibers has been shown to be a potential drug delivery system for the treatment of BV. PMID: 32393132 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 13, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Metabolic aspects of phenolic compounds from Triplaris gardneriana seeds in the management of oxidative stress.
Conclusion: It was demonstrated that the oral administration of EETg would provide phenolic compounds partially absorbable by the human gut and capable of providing health benefits associated with the inhibition of oxidative stress. Additionally, the results highlight the need to implement new approaches for the rational development of plant-based medicines. PMID: 32393135 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 13, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Odorranalectin modified PEG-PLGA/PEG-PBLG curcumin-loaded nanoparticle for intranasal administration.
Authors: Li X, Su J, Kamal Z, Guo P, Wu X, Lu L, Wu H, Qiu M Abstract Curcumin (Cur) is a promising drug for neurological diseases. Nevertheless, the application of Cur has been limited due to its difficulty in penetrating blood-brain barrier (BBB). Intranasal drug delivery, a noninvasive alternative delivery of Cur, can effectively help Cur cross BBB and inert into central nervous system directly. Odorranalectin (OL) which is the smallest lectin can prolong the residence time of Cur in the nasal mucosa and promote cellular uptake. In this work, a nasal delivery system incorporating OL modified Cur-loaded nanoparti...
Source: Drug Development and Industrial Pharmacy - May 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Galantamine transdermal patch shows higher tolerability over oral galantamine in rheumatoid arthritis rat model.
Authors: Kandil L, Hanafy A, Abdelhady S Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease of idiopathic etiology that triggers inflammatory cytokines compromising the joint mobility. Epidemiological evidences recommend the utilization of galantamine (GH) to reverse the anti-inflammatory reactions induced RA. Oral administration of GH is non-selectivity due to its association with serious gastrointestinal symptoms which, could hinder its therapeutic success. Therefore, the present study aimed to validate the therapeutic potential of GH transdermal patches as a novel application to constitute an eff...
Source: Drug Development and Industrial Pharmacy - May 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

BCS Class II drug loaded protein nanoparticles with enhanced oral bioavailability: in vitro evaluation and in vivo pharmacokinetic study in rats.
Authors: Kasekar NM, Singh S, Jadhav KR, Kadam VJ Abstract The aim of the study was to improve the bioavailability of atorvastatin calcium (ATC) by formulating polymeric nanoparticles with an easy and cost-effective approach. ATC entrapped gelatin nanoparticles (AEGNPs) were prepared by using a simple one-step desolvation method. The formed nanoparticles were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. Morphological study exhibited a homogenous spherical shape of formulated nanoparticles. FTIR studies revealed the chemical compatibili...
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition.
In this study, GGP modified daunorubicin plus dioscin liposomes are constructed and characterized. GGP modified daunorubicin plus dioscin liposome has suitable particle size, narrow PDI, zeta potential of about -5 mV, long cycle effect, and enhanced cell uptake due to surface modification of GGP making the liposome could enter the inside of the tumor to fully exert its anti-tumor effect. The results of in vitro experiments show that the liposome has superior killing effect on tumor cells and invasion. In vivo results indicate that the liposome prolongs the drug's prolonged time in the body and accumulates at the tum...
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Fabrication of extended-dissolution divalproex tablets: a green solvent-free granulation technique.
This study aims to produce stable taste masked divalproex sodium once daily tablets using solvent free hot melt granulation process.Methods: A lab scale high shear mixer granulator employing six meltable lipid binders (compritol®888 ATO, beeswax, gelucire®50/13, precirol® ATO5, stearyl alcohol, and geleol®) were used for the preparation of tablets. Quality control tests were performed on granules and tablets, and Box Behnken design was adopted to investigate the effect of binder concentration, impeller speed, and granulation time on the drug dissolution. Shelf and accelerated stability evaluation, taste ass...
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Proniosomes as a Carrier System for Transdermal Delivery of Clozapine.
Authors: Tareen FK, Shah KU, Ahmad N, Ur Rehman A, Shah SU, Ullah N Abstract The current study aimed to formulate the clozapine (CLZ) loaded proniosomal gel (PN) and evaluate it's in vitro release, ex vivo permeation and gel properties. CLZ is a BCS class II drug with low bioavailability of 27% and severe adverse drug reactions (ADRs) due to frequent dosing. Proniosomes offer a versatile pro-vesicular approach with potential in transdermal drug delivery. PN-CLZ gel was prepared by the coacervation phase separation method utilizing span-60, cholesterol and lecithin. Optimization of PN gel was done by hit & trial...
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Extraction of Triterpenoid compounds from Ganoderma Lucidum Spore Powder through a dual-mode sonication process.
Authors: Shen SF, Zhu LF, Wu Z, Wang G, Ahmad Z, Chang MW Abstract Development of drug products from natural sources enable advantageous treatment and therapy options. Bioactive compounds in Ganoderma lucidum spore powder (GLSP) are known for vast antibacterial, antioxidant and anti-cancer properties. Herein, we studied the use of dual-probe ultrasound to extract triterpenoids from GLSP and further investigated the bioactivity of resulting products. FTIR results confirm the presence of key peaks although dual-probe ultrasound varied extraction efficacy. Response surface methodology (RSM) was used to optimize extrac...
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Selective Laser Sintering 3D Printing - An Overview of the Technology and Pharmaceutical Applications.
Authors: Charoo NA, Barakh Ali SF, Mohamed EM, Kuttolamadom MA, Ozkan T, Khan MA, Rahman Z Abstract Food and Drug Administration (FDA) has approved a drug product (Spritam®) and many medical devices manufactured by 3-dimensional printing (3DP) processes for human use. There is immense potential to print personalized medicines using 3DP. Many 3DP methods have been reported in the literature for pharmaceutical applications. However, selective laser sintering (SLS) printing has remained least explored for pharmaceutical applications. There are many advantages and challenges in adopting a SLS method for fabrication...
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Investigating the influences of intermolecular interactions on viscoelastic performance of pressure sensitive adhesive by FT-IR spectroscopy and molecular modeling.
Conclusions: The present study described molecular mechanism of viscoelastic performance variation, especially the plasticizing effect. These results were essential for the design and development of transdermal patches from the viewpoint of viscoelastic performance. PMID: 32366133 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Cocrystallization with syringic acid presents a new opportunity for effectively reducing the hepatotoxicity of isoniazid.
Conclusion: INH-SYA cocrystal could effectively reducing the hepatotoxicity of isoniazid. PMID: 32366135 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - May 6, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

UHPLC-MS Phytochemical profiling, biological propensities and in-silico studies of Alhagi maurorum roots: A medicinal herb with multifunctional properties.
Authors: Saleem H, Sarfaraz M, Khan KM, Anwar MI, Zengin G, Ahmad I, Khan SU, Mahomoodally FM, Ahemad N Abstract The biological, chemical, and in silico properties of methanol and dichloromethane (DCM) extracts of Alhagi maurorum roots with respect to the antioxidant, enzyme inhibition, and phytochemical composition were evaluated. Total bioactive contents were determined spectrophotometrically, and the individual secondary metabolites composition was assessed via ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS) analysis. Antioxidant capacities were evaluated using a panoply of assays (2,2-...
Source: Drug Development and Industrial Pharmacy - May 2, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Augmented healing of full thickness chronic excision wound by rosmarinic acid loaded chitosan encapsulated graphene nanopockets.
Authors: Chhabra P, Chauhan G, Kumar A Abstract Nanoparticles have emerged as an important carrier system to treat wounds as they permit the topical administration of an antimicrobial drug in a sustained and effective manner. On the other hand, if active excipients are added during the formulation, such as chitosan or graphene oxide, the developed nanoformulation could significantly improve its potential for chronic wound healing. Given that, we have conceived the fabrication and evaluation of rosmarinic acid loaded chitosan encapsulated graphene nanoparticles (RA-CH-G-NPOs) formulation to enhance wound healing cap...
Source: Drug Development and Industrial Pharmacy - April 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preparation and characterization of metformin hydrochloride controlled-release tablet using fatty acid coated granules.
Authors: Kang JH, Chun MH, Cho MS, Kwon YB, Choi JC, Kim DW, Park CW, Park ES Abstract Metformin hydrochloride (MFM) is often used as a controlled-release (CR) tablet to reduce dosing frequency. However, the MFM CR tablet contains significant amounts of excipients and the tablet size is also large. Dosing convenience and patient compliance can be increased by reducing the size of the CR tablets. The aim of this study was to prepare and evaluate the MFM controlled-release tablet (MFM-CRT) using two types of release modulators, inner and outer. The MFM-CRT was prepared by coating the MFM granules using a binder solut...
Source: Drug Development and Industrial Pharmacy - April 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Solubility of codeine phosphate in carbitol +2-propanol mixture at different temperatures.
Authors: Rezaei H, Jouyban A, Martinez F, Barzegar-Jalali M, Rahimpour E Abstract The solubility profile of codeine phosphate in the carbitol and 2-propanol mixtures at 293.2 - 313.2 K are determined and correlated with some developed cosolvency models. Moreover, the density values of codeine phosphate saturated solutions are also determined and fitted with the Jouyban-Acree model. The model accuracy is investigated by calculating the mean relative deviations (MRD%). The thermodynamic parameters of codeine phosphate dissolution in the non-aqueous mixtures of carbitol and 2-propanol are also computed by using van't ...
Source: Drug Development and Industrial Pharmacy - April 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Enhancement of loading and oral bioavailability of curcumin loaded self-microemulsifying lipid carriers using Curcuma oleoresins.
Authors: Vijayan UK, Varakumar S, Sole S, Singhal RS Abstract The therapeutic applications of curcumin, a phenolic compound extracted from Curcuma species, is limited due to poor bioavailability. To enhance the bioavailability, self-microemulsifying drug delivery systems (SMEDDS) with curcumin were prepared. Ethyl oleate, Tween 80, and Transcutol® P with surfactant: co-surfactant ratio of 2:1 w/w was selected based on the solubility and pseudo-ternary phase diagrams. The optimized formulation (S-Eo3) was evaluated for use of spice oleoresins as curcumin bioenhancers. The oleophilic phase of curcumin containing ...
Source: Drug Development and Industrial Pharmacy - April 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development and Optimization of Osmotically Controlled Drug Delivery System for Poorly Aqueous Soluble Diacerein to Improve its Bioavailability.
In conclusion, the approach of enhancing solubility and wet-ability in accompany with optimized asymmetric osmotic pump system could serve as a promising delivery system and a way to improve the bioavailability of poorly aqueous soluble drugs. PMID: 32306779 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 22, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Effect of binary combinations of solvent system on permeability profiling of pure agomelatine across rat skin: A comparative study with statistically optimized polymeric nanoparticles.
CONCLUSION: The above observations concluded that binary combination of 33% PG-ethanol with 5%v/v transcutol-HP can serve as a solvent system of choice for effective transdermal delivery of agomelatine via nanoparticulate system. PMID: 32312082 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 22, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

In vivo and In vitro Biocompatibility Study of MnFe2O4 and Cr2Fe6O12 as Photosensitizer for Photodynamic Therapy and Drug Delivery of Anti-Cancer Drugs.
Authors: Aghajanzadeh M, Naderi E, Zamani M, Sharafi A, Naseri M, Danafar H Abstract In The present project, a variety of MnFe2O4 (Mn) and Cr2Fe6O12 (Cr)-based nanocarriers (NCs) were synthesized as photosensitizer and NCs for delivery of chemotherapeutic curcumin (CUR) and provide a new structure for Photodynamic Therapy (PDT). For determining efficiency of NCs release study, MTT assay, lethal dose test and hemolysis assay were carried out. The release study showed the release of CUR from NCs was pH-dependent, but, every NCs had its own behavior for releasing the drug. The data acquired from the release study show...
Source: Drug Development and Industrial Pharmacy - April 19, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Correction.
Authors: PMID: 32283945 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Development of darunavir proliposome powder for oral delivery by using box-bhenken design.
Authors: Bhusari S, Ansari I, Chaudhary A Abstract The aim of present study is to develop Darunavir pro-liposome powder for oral delivery. Darunavir-loaded oral pro-liposome powder (OPP) was prepared by a solvent evaporation technique with varying independent variables at three different levels. Based on different levels pro-liposome powder formulation was optimized by using Box-Behnken design. The formulations were analyzed for its size distribution, entrapment efficiency and surface morphology. Optimized pro-liposome batch A was evaluated for physical parameter, morphological parameters, entrapment efficiency, fo...
Source: Drug Development and Industrial Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Filling of Lactose-based Formulations in a Tamping-Pin Capsule Filler.
This study demonstrated that selection of process parameters and mechanical adaptions could enhance the filling performance, especially in continuous production, since they reduce the powder volume in the process. Moreover, we showed that a tamping pin system is capable of successfully filling a broad range of powders with various material characteristics and can potentially be used in a continuous production mode. PMID: 32290729 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Caffeine inhalation effects on locomotor activity in mice.
This study is useful not only for creating new administration methods of caffeine but also for adjusting caffeine storage and management. PMID: 32292092 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Performance and toxicity of different absorption enhancers used in the preparation of poloxamer thermosensitive in situ gels for ketamine nasal administration.
Authors: Xia Y, Li L, Huang X, Wang Z, Zhang H, Gao J, Du Y, Chen W, Zheng A Abstract The purpose of this study was to investigate the nasal absorption rate and nasal mucosal toxicity of thermosensitive ketamine in situ gels containing various absorption enhancers. The optimal composition ratio for the gel matrix was determined to be 17.2% Poloxamer 407 and 2% Poloxamer 188, as this combination resulted in solutions with a gelation point within the range found in the nasal cavity. Ketamine gels containing the tested enhancers, namely ethylenediaminetetraacetic acid disodium salt, hydroxypropyl-β-cyclodextrin, ...
Source: Drug Development and Industrial Pharmacy - April 16, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Latanoprost niosomes as a sustained release ocular delivery system for the management of glaucoma.
Conclusion: Latanoprost niosomal Pluronic® F127 gel may find applications in glaucoma management. PMID: 32281424 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 15, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Effect of different molecular weight PLGA on flurbiprofen nanoparticles: Formulation, characterization, cytotoxicity and in vivo anti-inflammatory effect by using HET-CAM assay.
Conclusions: It could be concluded that FLB loaded NPs seem to be a promising extended release drug delivery system for oral administration with a low dose and high efficiency. PMID: 32281428 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 15, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Formulation of lyophilized oily-core poly- Ɛ-caprolactone nanocapsules to improve oral bioavailability of Olmesartan Medoxomil.
Conclusion: It is concluded that formulation of lyophilized ONC for OM can significantly enhance its oral bioavailability and consequently, its therapeutic efficacy and patient compliance. PMID: 32275456 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 12, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Oxiconazole Nitrate Solid Lipid Nanoparticles: Formulation, In-vitro Characterization and Clinical Assessment of An Analogous Loaded Carbopol Gel.
Authors: Mahmoud RA, Hussein AK, Nasef GA, Mansour HF Abstract The aim of the present work was to develop a promising drug delivery system of oxiconazole nitrate-loaded solid lipid nanoparticles (SLNs) topical gel to enhance the drug effectiveness for the treatment of Tinea infection. SLNs were prepared by emulsification-solvent evaporation method. Particle size and entrapment efficiency of the prepared SLNs were investigated. An appropriate formulation was selected and examined for morphology and physicochemical characterization adopting Scanning electron microscope and Differential scanning colorimetry. In-vitro ...
Source: Drug Development and Industrial Pharmacy - April 9, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Preformulation Studies of L-Glutathione: Physicochemical Properties, Degradation Kinetics, and In Vitro Cytotoxicity Investigations.
Conclusions: Precise preformulation parameters of GSH were obtained, and these are imperative for the development and optimization of advanced GSH formulations. PMID: 32249604 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 8, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

A plausible Way for Excretion of Metal Nanoparticles via Active Targeting.
This study confirms that QDs-VAP can target the podocytès sstrs then can be cleared via podocyte cells. Moreover, these results are considered a highly promising approach for future therapy, targeting, clearance, and diagnosis of podocyte-associated diseases. PMID: 32250174 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 8, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Glibenclamide Nanosuspension Inhaler: Development, In vitro and In vivo Assessment.
Conclusion These results confirmed that glibenclamide nanosuspension inhaler enhance hypoglycemic effectiveness and reduce adverse effect of glibenclamide, opening up new dosage form in Diabetes mellitus treatment. PMID: 32250179 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 8, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Formulation and Evaluation of Niosomal Vesicles containing Ondansetron HCL for Trans-mucosal nasal drug delivery.
Authors: Teaima MH, El Mohamady AM, El-Nabarawi MA, Mohamed AI Abstract Ondansetron HCl is a (5-HT3) serotonin receptor antagonist, used as anti-emetic drug in combination with anticancer agents. Conventional dosage forms have poor bioavailability and patient compliance. These problems can be reduced by the use of nasal niosomal thermo reversible in situ gelling system; Niosomes were formulated using various surfactants (Span 60, Span 80, Tween 20 and Tween 80) in different ratios using thin film hydration technique. Niosomes were evaluated for particle size, zeta potential, Transmission Electron Microscopy (TEM) i...
Source: Drug Development and Industrial Pharmacy - April 8, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Step-wise approach to developing a scale-independent design space for functional tablet coating process.
The objective of this study is to present a practical example of a scale-independent design space development using a step-wise approach. A detailed description of the development process with a systematic outline of the main steps is provided. Design space is developed for film coating of tablets with moisture protective polyvinyl alcohol (PVA) based coating. The impact of scale-independent coating process parameters on the properties of film-coated tablets (FCT), i.e. water activity and film coating protection ability, and consequently on product long-term stability is explored. The main finding is that with model simpli...
Source: Drug Development and Industrial Pharmacy - April 3, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Eye drops and eye gels of levofloxacin: comparison of ocular absorption characterizations and therapeutic effects in the treatment of bacterial keratitis in rabbits.
Authors: Li G, Xu L, Jiang M, Wu X Abstract The aim was to reveal the characteristic profiles of the marketed levofloxacin eye drops (5 mg/ml) and levofloxacin eye gel (3 mg/g) from the pharmacokinetics and pharmacodynamics views of rabbits' eyes. A mild and a heavy bacterial keratitis models in rabbits were established. Different regimens of levofloxacin eye drops and eye gel, including phosphate buffer solution (the PBS group), the 4-Sol +1-Gel group (rabbits were treated with 4 doses of levofloxacin eye drops and 1 dose levofloxacin eye gel per day), the 3-Sol +1-Gel group (3 doses drops and 1 dose...
Source: Drug Development and Industrial Pharmacy - April 3, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Sonication tailored enhance cytotoxicity of naringenin nanoparticle in pancreatic cancer: Design, optimization, and in vitro studies.
Authors: Akhter MH, Kumar S, Nomani S Abstract Objective: In vitro, optimization, characterization and cytotoxic studies of NAR NPs to against pancreatic cancer.Method: The sonication tailored NARG loaded poly (lactide-co-glycolic acid) (PLGA) nanoparticle (NPs) was fabricated for potential cytotoxic effect against pancreatic cancer. NARG NPs were prepared by emulsion-diffusion evaporation technique applying Box Behnken experimental design based on 3-level and 3-factors. The effect of independent variables surfactant concentration (X1), polymer concentration (X2) and sonication time (X3) were studied on responses p...
Source: Drug Development and Industrial Pharmacy - March 29, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Comparison between novel star-like redox-sensitive amphiphilic block copolymer and its linear counterpart copolymer as nanocarriers for Doxorubicin.
Authors: Murjan S, Saeedi S, Nabid MR Abstract Linear and star-like redox-sensitive amphiphilic block copolymers have been studied as anticancer drug delivery systems. However, few reports directly compared the properties of those two structures especially when they are used as nanocarriers for antitumor drugs. To address this, a novel star-like copolymer and its linear counterpart were synthesized with a hydrophobic/redox-responsive/hydrophilic structure. The overall molecular weight of the star-shaped copolymer was nearly equal to that of the linear counterpart.The star-like micelles exhibit size of 90 nm,...
Source: Drug Development and Industrial Pharmacy - March 27, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Effect of Gamma Sterilization on the Properties of Microneedle Array Transdermal Patch System.
Authors: H P S, Matadh V A, Suresh S, Paul Guin J, Murthy S N, Kanni P, Varshney L, H N S Abstract Soluble Microneedles (MNs) of four different hydrophilic polymers namely Sodium Carboxymethyl Cellulose (CMC), Polyvinylpyrrolidone (PVP) K30, PVP K90 and Sodium Hyaluronate (HU) were fabricated by mold casting technique. When exposed to gamma radiation, a dose of 25 Kilogray (kGy) was found to render the microneedle (MN) sterile. However, CMC was found to form MN with poor mechanical properties whereas PVP K30 MNs were drastically deformed upon exposure to applied dose as observed in bright field microscopy. Scanning...
Source: Drug Development and Industrial Pharmacy - March 26, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Mesoporous silica particles as potential carriers for protein drug delivery: protein immobilisation and the effect of displacer on γ-globulin release.
Mesoporous silica particles as potential carriers for protein drug delivery: protein immobilisation and the effect of displacer on γ-globulin release. Drug Dev Ind Pharm. 2020 Mar 12;:1-33 Authors: Ajiboye AL, Trivedi V, Mitchell J Abstract The adsorption of γ-globulin was evaluated with experiments with silica particles marketed as Syloid AL1-FP (SAL), XDP-3150 (SXDP), and 244FP (SFP). The influence of pH, pore sizes, and degree of surface porosity on the extent of γ-globulin immobilisation was examined. Protein adsorption on these particles was largely related to their surface poros...
Source: Drug Development and Industrial Pharmacy - March 13, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Impact of solidification on micromeritic properties and dissolution rate of self-nanoemulsifying delivery system loaded with docosahexaenoic acid.
Authors: Ghosh D, Singh SK, Khursheed R, Pandey NK, Kumar B, Kumar R, Kumari Y, Kaur G, Clarisse A, Awasthi A, Gulati M, Jain SK, Porwal O, Bayrakdar E, Sheet M, Gowthamarajan K, Gupta S, Corrie L, Gunjal P, Gupta RK, Singh TG, Sinha S Abstract Development of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of liquid-SNEDDS (L-SNEDDS) formulation was Labrafil® M1944 CS, 47% v/v Tween 80, 27% v/v Transcutol P, and 0.1% v/v DHA. L-SNEDDS were solidified using Syloid XDP 3150 as solid porous ca...
Source: Drug Development and Industrial Pharmacy - March 13, 2020 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research