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An empirical predictive model for determining the aqueous solubility of BCS class IV drugs in amorphous solid dispersions
CONCLUSION: The developed empirical model demonstrated robustness and predicted the aqueous solubility of model drugs from the ASDs of model polymer matrices with an accuracy greater than 80%.PMID:38318700 | DOI:10.1080/03639045.2024.2315477 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 6, 2024 Category: Drugs & Pharmacology Authors: Sridivya Raparla Charina Lampa Xiaoling Li Bhaskara R Jasti Source Type: research

Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation
CONCLUSION: The newly developed DFX nanoform demonstrated a high potential as a promising therapeutic agent for BC treatment.PMID:38305197 | DOI:10.1080/03639045.2024.2314189 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 2, 2024 Category: Drugs & Pharmacology Authors: Nadeen Diaa Abdel-Wahab Mohamed Fawzi Kabil Ibrahim M El-Sherbiny Mohamed F Salama Gehad El-Sayed El-Said El-Sherbini Source Type: research

Physicochemical interaction of rifampicin and ritonavir-lopinavir solid dispersion: an in-vitro and ex-vivo investigation
CONCLUSION: RIF, RTV and LOP in presence of each other on pH-shift, results in co-precipitation in the amorphous form (miscible) which leads to reduction in the highest attainable degree of supersaturation. This reduction corresponds to the mole fraction of the RIF, RTV and LOP within the studied system. These findings suggest that the concomitant administration of these drugs may lead to physicochemical interactions and possible ineffective therapy.PMID:38305806 | DOI:10.1080/03639045.2024.2309508 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 2, 2024 Category: Drugs & Pharmacology Authors: Athira R Nair Sai Krishna Anand Vullendula Dani Lakshman Yarlagadda Brahmam Bheemisetty Swapnil J Dengale Krishnamurthy Bhat Source Type: research

Comparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits
CONCLUSION: As per findings of the in vivo investigation, the Glimepiride ODT would be beneficial in terms of patient compliance, quick onset of action, and increased bioavailability.PMID:38265062 | DOI:10.1080/03639045.2024.2307421 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 24, 2024 Category: Drugs & Pharmacology Authors: Altaf Ur Rahman Fazli Nasir Muzna Ali Khattak Talaya Hidayatullah Sadia Pervez Syeda Rabqa Zainab Arbab Tahir Ali Shazma Gohar Gul E Maryam Waleed H Almalki Source Type: research

Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma
CONCLUSIONS: BO-modified DTX plus TET micelles may provide a new treatment method for drug-resistant brain gliomas.PMID:38235554 | DOI:10.1080/03639045.2024.2302886 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 18, 2024 Category: Drugs & Pharmacology Authors: Yang Liu Jia-Yu Cai Yang Liu Lu Zhang Rui-Bo Guo Xue-Tao Li Ling-Yue Ma Liang Kong Source Type: research

Effect of stoichiometry upon the characteristics of quercetin-arginine cocrystals formulated through solution crystallization
CONCLUSION: Morphology of cocrystals remained unaffected by the solvent type, stoichiometry and the presence of surfactant. We noticed that the cocrystals could improve the aqueous solubility of QCT.PMID:38226968 | DOI:10.1080/03639045.2024.2306281 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 16, 2024 Category: Drugs & Pharmacology Authors: Mahima Mishra Shivanshu Agrawal Pratap Bahadur Sanjay Tiwari Source Type: research

Integrating chemical similarity and bioequivalence: an overall evaluation of the quality consistency of traditional decoction and dispensing granule decoction of Amomum villosum 
CONCLUSION: The chemical composition of DGD and TD differed. The biological activity of DGD-A/B was consistent with that of TD, while the difference between DGD-C and TD was significant. A comprehensive evaluation showed that TD exhibited better quality than DGD. DGD manufacturers should optimize the preparation process to enhance product quality.PMID:38194223 | DOI:10.1080/03639045.2024.2303381 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 9, 2024 Category: Drugs & Pharmacology Authors: Yousong Yue Haiyang Li Manwen Xu Lijie Ma Xiaopeng Wang Yan Miao Lu Zhang Xuelin Li Ruixin Liu Source Type: research

Integrating chemical similarity and bioequivalence: an overall evaluation of the quality consistency of traditional decoction and dispensing granule decoction of Amomum villosum 
Conclusion: The chemical composition of DGD and TD differed. The biological activity of DGD-A/B was consistent with that of TD, while the difference between DGD-C and TD was significant. A comprehensive evaluation showed that TD exhibited better quality than DGD. DGD manufacturers should optimize the preparation process to enhance product quality.PMID:38194223 | DOI:10.1080/03639045.2024.2303381 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 9, 2024 Category: Drugs & Pharmacology Authors: Yousong Yue Haiyang Li Manwen Xu Lijie Ma Xiaopeng Wang Yan Miao Lu Zhang Xuelin Li Ruixin Liu Source Type: research

Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid technology
CONCLUSIONS: Overall, it has been shown herein that the supercritical fluid technology foaming method is promising in masking the bitter taste of bitter ingredients.PMID:38180038 | DOI:10.1080/03639045.2023.2298892 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 5, 2024 Category: Drugs & Pharmacology Authors: Hadeia Mashaqbeh Rana M Obaidat Mo'tasem M Alsmadi Source Type: research

Doxorubicin-sanguinarine nanoparticles: Formulation and evaluation of breast cancer cell apoptosis and cell cycle
Conclusions: Cellular and molecular studies suggested adjuvant chemosensitizers SA and SN to reverse MDR in breast cancer cells.PMID:38180322 | DOI:10.1080/03639045.2024.2302557 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 5, 2024 Category: Drugs & Pharmacology Authors: Mahmoud Zaki El-Readi Majed Abdurhman Abdulkarim Ahmed A H Abdellatif Mohamed E Elzubeir Bassem Refaat Mohammad Althubiti Riyad Adnan Almaimani Mohammed Hasan Mukhtar Issa Saad Al-Moraya Safaa Yehia Eid Source Type: research

Solvent-Free Method for Masking the Bitter Taste of Azithromycin Dihydrate Using Supercritical Fluid Technology
Conclusions: Overall, it has been shown herein that the supercritical fluid technology foaming method is promising in masking the bitter taste of bitter ingredients.PMID:38180038 | DOI:10.1080/03639045.2023.2298892 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - January 5, 2024 Category: Drugs & Pharmacology Authors: Hadeia Mashaqbeh Rana M Obaidat Mo'tasem M Alsmadi Source Type: research