Enhanced dissolution rates of glibenclamide through solid dispersions on microcrystalline cellulose and mannitol, combined with phosphatidylcholine
CONCLUSION: The study suggests that physical solid dispersions of SG on MC and M, along with their combination with P, can effectively enhance the dissolution rate of G. These findings may be valuable in developing of oral solid drug dosage forms utilizing SGA, SGM, SGAP and SGMP.PMID:38385210 | DOI:10.1080/03639045.2024.2321388 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 22, 2024 Category: Drugs & Pharmacology Authors: Wanlop Weecharangsan Robert J Lee Source Type: research

Developing a rapid analytical method for simultaneous determination of apigenin and gallic acid: validation and application in a nanoliposomal formulation
CONCLUSION: The described HPLC method was shown to be suitable, sensitive, and reproducible for the simultaneous identification and quantification of apigenin and gallic acid. The analytical results were accurate and precise, with good recovery, low limit of detection, and the chromatographic assay was accomplished in less than 3 min, suggesting the suitability of the method for routine analysis of both drugs in pharmaceutical formulations.PMID:38374658 | DOI:10.1080/03639045.2024.2318386 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 20, 2024 Category: Drugs & Pharmacology Authors: Ahmed Gouda Omar S Sakr Maha Nasr Omaima A Sammour Source Type: research

Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation
CONCLUSION: MPEO-N nanoparticles as a natural antioxidant, exhibited a favorable radioprotective effect by a significant reduction in the percentage of apoptosis and necrosis of irradiated PBMCs.PMID:38334353 | DOI:10.1080/03639045.2024.2317297 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 9, 2024 Category: Drugs & Pharmacology Authors: Nima Hamzian Abolfazl Nickfarjam Ali Shams Fatemeh Haghiralsadat Moslem Najmi-Nezhad Source Type: research

Formulation, Optimization and Full Characterization of Mirtazapine Loaded Aquasomes: A new technique to boost antidepressant effects
ConclusionThese results confirmed that the antidepressant effect of MRT was significantly boosted in formulated aquasomes, and thereby they provide a promising carrier nano vesicular system for effective delivery of MRT.PMID:38334395 | DOI:10.1080/03639045.2024.2313538 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 9, 2024 Category: Drugs & Pharmacology Authors: Lamiaa Mohamed Hussein Ali Aya Mohamed Dawaba Shereen Ahmed El-Adawy Source Type: research

Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation
CONCLUSION: MPEO-N nanoparticles as a natural antioxidant, exhibited a favorable radioprotective effect by a significant reduction in the percentage of apoptosis and necrosis of irradiated PBMCs.PMID:38334353 | DOI:10.1080/03639045.2024.2317297 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - February 9, 2024 Category: Drugs & Pharmacology Authors: Nima Hamzian Abolfazl Nickfarjam Ali Shams Fatemeh Haghiralsadat Moslem Najmi-Nezhad Source Type: research