Beneficial Effects of a Perindopril/Indapamide Single-Pill Combination in Hypertensive Patients with Diabetes and/or Obesity or Metabolic Syndrome: A Post Hoc Pooled Analysis of Four Observational Studies
AbstractIntroductionTo assess real-life effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in patients with hypertension (HT) and type  2 diabetes mellitus (T2DM), obesity and/or metabolic syndrome (MetS).MethodsThis post hoc analysis pooled raw data from four large observational studies (FORTISSIMO, FORSAGE, ACES, PICASSO). Patients, most with uncontrolled blood pressure (BP) on previous treatments were switched to Per/Ind (10  mg/2.5 mg) SPC at study entry. Office systolic and diastolic blood pressures (SBP and DBP) were measured at baseline, 1 month and 3 months.Re...
Source: Advances in Therapy - February 25, 2021 Category: Drugs & Pharmacology Source Type: research

Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group
Br J Dermatol. 2021 Feb 20. doi: 10.1111/bjd.19880. Online ahead of print.ABSTRACTBACKGROUND: Case-control studies report a dose-dependent increased risk of skin cancer in users of hydrochlorothiazide (HCTZ) vs non-users. The degree to which other thiazides and thiazide-like diuretics (TZs) are associated with skin cancer is less certain.OBJECTIVES: To assess the risk of skin cancer in new users of different TZs compared to new users of calcium channel blockers (CCBs).METHODS: We conducted a cohort study using a UK primary-care database (1998-2017), including 271 154 new TZ users (87.6% bendroflumethiazide [BFT], 5.8% inda...
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: R Schneider D Reinau S Stoffel S S Jick C R Meier J Spoendlin Source Type: research

Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group.
Abstract BACKGROUND: Case-control studies report a dose-dependent increased risk of skin cancer in users of hydrochlorothiazide (HCTZ) vs non-users. The degree to which other thiazides and thiazide-like diuretics (TZs) are associated with skin cancer is less certain. OBJECTIVES: To assess the risk of skin cancer in new users of different TZs compared to new users of calcium channel blockers (CCBs). METHODS: We conducted a cohort study using a UK primary-care database (1998-2017), including 271 154 new TZ users (87.6% bendroflumethiazide [BFT], 5.8% indapamide, and 3.6% HCTZ) and 275 263 CCB...
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J Tags: Br J Dermatol Source Type: research

Development and Validation of a Novel UV Spectrophotometric Method for Simultaneous Analysis of Amlodipine Indapamide and Perindopril
ERICA ALVES, CELINA NAZARETH* AND SANELLY PEREIRA (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - January 19, 2021 Category: Drugs & Pharmacology Source Type: research

Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis
AbstractAs the underlying pathophysiology of progressive forms of multiple sclerosis (MS) remains unclear, current treatment strategies are inadequate. Progressive MS is associated with increased oxidative stress and neuronal damage in lesions along with an extensive representation of activated microglia/macrophages. To target these disease mechanisms, we tested the novel combination of generic medications, hydroxychloroquine (HCQ), and indapamide, in tissue culture and in mice. HCQ is an anti-malarial medication found to inhibit microglial activation and to ameliorate disease activity in experimental autoimmune encephalom...
Source: Neurotherapeutics - January 6, 2021 Category: Neurology Source Type: research

Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC-MS/MS method; Application to a bioequivalence study.
Abstract A robust and rapid UPLC-MS/MS method has been developed, optimized, and validated for determination of amlodipine (AML), indapamide (IND) and perindopril (PRN) in human plasma. A positive electrospray ionization mode was used in Xevo TQD LC-MS/MS instrument. A single sample preparation step using extraction technique was applied to extract the three analytes from plasma samples. There was no need to extract indapamide from blood samples in a further step. Extraction of the three drugs and internal standards was done using a solvent mixture composed of methyl tertiary butyl ether, dichloromethane, and ethy...
Source: Biomedical Chromatography : BMC - December 11, 2020 Category: Biomedical Science Authors: Rezk MR, Badr KA Tags: Biomed Chromatogr Source Type: research

Effectiveness of Perindopril/Indapamide Single-Pill Combination in Uncontrolled Patients with Hypertension: A Pooled Analysis of the FORTISSIMO, FORSAGE, ACES and PICASSO Observational Studies
AbstractIntroductionOur objective was to determine the effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in a broad range of patient profiles, including subgroups with varying hypertension severity, age and cardiovascular risk profiles.MethodsPatient data from four large prospective observational studies (FORTISSIMO, FORSAGE, PICASSO, ACES) were pooled. In each study, patients already treated for hypertension were switched to Per/Ind 10/2.5 mg SPC and systolic and diastolic blood pressure (SBP/DBP) measured at the 1-month (M1) and 3-month (M3) visits. Study endpoints included change in SBP a...
Source: Advances in Therapy - November 5, 2020 Category: Drugs & Pharmacology Source Type: research

Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients.
Authors: Borghi C, Soldati M, Bragagni A, Cicero AFG Abstract INTRODUCTION: ACE-inhibitors (ACEI) and diuretics are the typical first-line antihypertensive drugs with complementary mechanisms of action. The present paper is summarizing the evidence supporting the efficacy of their combination in a broad range of hypertensive patients. AREAS COVERED: This source of data are different trials investigating the use of ACEI and diuretics in different populations of patients. The available evidence supports some advantage for thiazide-type compounds (chlortalidone-CHT and indapamide-IND) in the prevention of major CV...
Source: Expert Opinion on Drug Safety - October 15, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Effect of Perindopril/Indapamide on Cerebral Blood Flow in Middle-Aged, Treatment-Na ïve Patients with Hypertension
This study evaluated the impact of a perindopril arginine/indapamide (Pa/I) single-pill combination (SPC) on CBF in middle-aged patients.MethodsA total of 22 treatment-na ïve patients with essential hypertension and at least one hypertension-mediated organ damage and 41 healthy controls were enrolled. At baseline, all participants underwent brain magnetic resonance imaging (MRI); patients with hypertension underwent an additional MRI at end of follow-up. Arterial sp in labeling (ASL) was used to calculate CBF in the frontal lobe cortical plate. Patients with hypertension received once-daily Pa/I 5 mg/1.25 mg...
Source: Advances in Therapy - October 6, 2020 Category: Drugs & Pharmacology Source Type: research

Analytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine
Publication date: December 2020Source: Microchemical Journal, Volume 159Author(s): Sarah S. Saleh, Hayam M. Lotfy, Gizem Tiris, Nevin Erk, Yasmin Rostom (Source: Microchemical Journal)
Source: Microchemical Journal - October 1, 2020 Category: Chemistry Source Type: research

Blood-pressure Lowering Efficacy and Safety of Perindopril / Indapamide / Amlodipine Single-pill Combination in Hypertensive Patients: Phase III Trial in India.
Conclusion: This study showed the clinical efficacy, safety and acceptability of the perindopril/indapamide/amlodipine SPC in patients with grade 2/3 hypertension inadequately controlled with two-drug therapy. The clinical effectiveness was observed in more than 96 % patients. The benefit of single-pill combination (SPC) therapy in hypertension control was reconfirmed in this study. PMID: 32978924 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - September 29, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Introduction of cellulose-cysteine Schiff base as a new ligand for the fabrication of blue fluorescent gold nanoclusters for the detection of indapamide drug
Publication date: 1 December 2020Source: Journal of Molecular Liquids, Volume 319Author(s): Suresh Kumar Kailasa, Mehul R. Kateshiya, Naved I. Malek (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - September 25, 2020 Category: Molecular Biology Source Type: research

Acute bilateral myopia induced by Triplixam: a case report
Side effects of the systemic drugs used to treat eyes are not common. Triplixam is used to treat systemic hypertension and contains amlodipine, indapamide and perindopril arginine as active ingredients which m... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - September 22, 2020 Category: Opthalmology Authors: Ruta Jaruseviciene and Ginte Sirvydyte Tags: Case report Source Type: research

Triamterene in lithium-induced nephrogenic diabetes insipidus: a case report
We describe the case of an 81-year-old woman with bipolar treated with lithium and no previous history of diabetes insipidus. She was hospitalized due to disturbance of consciousness and was diagnosed with, hypercalcemia, hyperparathyroidism, and NDI. Parathyroidectomy was contraindicated and parathyroid hormone level was improved insufficiently after cinacalcet initiation, percutaneous ethanol injection therapy was performed for the enlarged parathyroid gland. After improvement in hypercalcemia and unsuccessful indapamide treatment, triamterene was administrated to control polyuria. Lithium is one of the indispensable mai...
Source: CEN Case Reports - August 8, 2020 Category: Urology & Nephrology Source Type: research

Antihypertensives and melanoma: An updated review.
Abstract Antihypertensive medications are commonly prescribed and well-studied. Given the widespread use and potential side effects, various theories have been made about the relationship between antihypertensives and malignancy, including melanoma. This review describes the current understanding of the most commonly prescribed antihypertensives and their associations with melanoma. The literature demonstrates that diuretics, specifically hydrochlorothiazide and indapamide, may increase the risk of melanoma. While there is no evidence that antihypertensives have a role in melanoma prevention, nonselective β-b...
Source: Pigment Cell and Melanoma Research - August 4, 2020 Category: Cytology Authors: Williams NM, Vincent LT, Rodriguez GA, Nouri K Tags: Pigment Cell Melanoma Res Source Type: research

An Unusual Cause of Regurgitation and Heartburn In a Patient With Fundoplication
Question: A 60-year-old woman with a history of gastroesophageal reflux disease (submitted to Nissen fundoplication fourteen years before) underwent esophagogastroduodenoscopy (EGD) due to occasional symptoms of heartburn and regurgitation with 6 months of duration. Her usual medication included long time use of indapamide, pravastatin and alprazolam and one-year use of glucosamine and diclofenac for arthritis. She denied alcohol, tobacco, or illicit drug use. Her physical examination and her laboratory findings were unremarkable. (Source: Gastroenterology)
Source: Gastroenterology - March 2, 2020 Category: Gastroenterology Authors: Joel Ferreira-Silva, Rui Morais, Guilherme Macedo Tags: Practical Teaching Case Source Type: research

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
AbstractIntroductionOverweight and obesity are increasing worldwide and are associated with an increased risk for cardiovascular disease (CVD). The aim of this study was to examine the burden of CVD risk factors among normal weight, overweight, and obese subjects with hypertension, and to evaluate the effectiveness of switching to a single-pill combination (SPC) of perindopril arginine/indapamide for blood pressure (BP) control in overweight and obese subjects treated in routine clinical practice.MethodsFORSAGE was a 3-month, multicenter, observational, open-label study conducted in Russian patients with uncontrolled arter...
Source: Cardiology and Therapy - January 31, 2020 Category: Cardiology Source Type: research

Cardiac arrhythmia triggered by diuretic-induced hyponatremia.
We present an unusual case of indapamide-induced hyponatremia and hypokalemia complicated by cardiac arrhythmia. The adverse drug reaction was reversible and non-life-threatening, but this case serves as a reminder that careful evaluation and constant monitoring are necessary when prescribing diuretics. PMID: 31827736 [PubMed] (Source: American Family Physician)
Source: American Family Physician - December 14, 2019 Category: Primary Care Authors: Lu HT, Loo HC, Ng KS, Wong YO, Nordin R Tags: Malays Fam Physician Source Type: research

GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
Publication date: Available online 28 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Olga Begou, Kathrin Drabert, Georgios Theodoridis, Dimitrios TsikasAbstractAcetazolamide (molecular mass (MM), 222) belongs to the class of sulfonamides (R-SO2-NH2) and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity. Acetazolamide is excreted unchanged in the urine. Here, we report on the development, validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human urine. The method is based on evaporat...
Source: Journal of Pharmaceutical Analysis - November 29, 2019 Category: Drugs & Pharmacology Source Type: research

Unravelling the inhibitory and cytoprotective potential of diuretics towards amyloid fibrillation.
Abstract Protein misfolding and deposition of aggregated proteins inside as well as outside of the cells have been associated with several neurotoxic and neurodegenerative disorders like Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. that could be controlled by anti-aggregation methodologies employing either inhibition or disaggregation of toxic aggregates. Also, the Alzheimer's disease develops in later life is somehow related to the high mid-life blood pressure. Therefore the present work targets the amyloid inhibiting potential of diuretics (a class of antihypertensive drugs) - Indapamide (IN...
Source: International Journal of Biological Macromolecules - November 15, 2019 Category: Biochemistry Authors: Malik S, Khursheed Siddiqi M, Majid N, Masroor A, Moasfar Ali S, Khan RH Tags: Int J Biol Macromol Source Type: research

Feasibility of 24-h central blood pressure monitoring: experience from multinational clinical trial assessing the efficacy of perindopril/indapamide/amlodipine
Objectives: Brachial blood pressure (BP) is a predictor of cardiovascular events. Evidence suggests that central BP (CBP) provides additional information for cardiovascular risk assessment. Methods to assess 24-h CBP are now available. Our objective was to assess the feasibility of 24-h CBP monitoring in clinical trials and its ability for drug evaluation. Methods: Data are issued from an international phase 3 randomized clinical trial comparing the efficacy of perindopril/indapamide/amlodipine vs. perindopril/indapamide (Per/Ind), in uncontrolled hypertensive patients treated with Per/Ind. 24-h ambulatory BP monitori...
Source: Journal of Hypertension - November 4, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement and hemodynamic aspects Source Type: research

Simultaneous Evaluation of Dissolution and Permeation of Oral Drug Solid Formulations for Predicting Absorption Rate-Limiting Factors and In Vitro-In Vivo Correlations: Case Study Using a Poorly Soluble Weakly Basic Drug.
In this study, the modified biorelevant media with some solubilizers and pH modifiers were integrated into the drug dissolution/absorption simulating system (DDASS). Indapamide, a poorly soluble compound (pKa = 8.8), was selected to validate the applicability of the modified biorelevant media. The elution and permeation dynamics of indapamide were investigated by using appropriate solubilizing agents in the DDASS. The absorption behaviors were analyzed after oral administration of indapamide in beagle dogs. The absorption rate-limiting steps and IVIVCs were predicted from the dissolution-permeation-absorption dynamic param...
Source: AAPS PharmSciTech - October 23, 2019 Category: Drugs & Pharmacology Authors: Li Z, He X, Tian S, Feng G, Huang C, Xun M, Wu Z, Wang Y Tags: AAPS PharmSciTech Source Type: research

Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Alberto Mazza, Danyelle M. Townsend, Laura Schiavon, Gioia Torin, Salvatore Lenti, Ciro Rossetti, Gianluca Rigatelli, Domenico RubelloAbstractBackgroundMost antihypertensive drugs used in monotherapy or in combination therapy reduce the left ventricular mass index (LVMI). However, little is known about the effects on LVMI of a triple fixed-dose combination (TFC) therapy, containing in a single pill an angiotensin-converting enzyme inhibitor (ACEI), a diuretic and a calcium channel blocker (CCB).MethodsIn this prospective open-lab...
Source: Biomedicine and Pharmacotherapy - October 16, 2019 Category: Drugs & Pharmacology Source Type: research

Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects.
Abstract BACKGROUND: Most antihypertensive drugs used in monotherapy or in combination therapy reduce the left ventricular mass index (LVMI). However, little is known about the effects on LVMI of a triple fixed-dose combination (TFC) therapy, containing in a single pill an angiotensin-converting enzyme inhibitor (ACEI), a diuretic and a calcium channel blocker (CCB). METHODS: In this prospective open-label study, 92 patients with essential hypertension were randomized to treatment with a TFC of perindopril/indapamide/amlodipine at different doses or a triple free combination therapy (FCT) including ACEI/diure...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 14, 2019 Category: Drugs & Pharmacology Authors: Mazza A, Townsend DM, Schiavon L, Torin G, Lenti S, Rossetti C, Rigatelli G, Rubello D Tags: Biomed Pharmacother Source Type: research

Efficacy of a new single-pill combination of a thiazide-like diuretic and a calcium channel blocker (indapamide sustained release/amlodipine) in essential hypertension
Objectives: The current international, 12-week, double-blind, randomized, controlled trial assessed the efficacy and safety of indapamide sustained release/amlodipine single-pill combination (SPC) in mild-to-moderate hypertensive patients. Methods: Following a 4-week run-in period on amlodipine 5 mg, patients (SBP 150–180 mmHg and/or DBP  (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Evaluation of Clinical Acceptability of Perindopril / Indapamide Single-pill Combination in Moderate to Severe Hypertension.
In this study, 173 hypertensive patients, with a mean age of 51 years were enrolled at 3 centres from different geographic areas within India. Mean SBP/DBP decreased significantly from baseline (155.70 (±10.39) / 95.72 (±6.99) mmHg) over 90 days (30.31 (±14.15) / 17.14 (±9.33) mmHg; p
Source: Journal of the Association of Physicians of India - September 30, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Molecules, Vol. 24, Pages 2731: Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage
This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibenclamide, hydrocortisone, hydrochlorothiazide, ketoconazole, and sulfathiazole were used as model APIs. The parameters used to assess the supersaturation potential and crystallization kinetics were the maximum supersaturation concentration (Cmax,app), the area under the curve (AUC), and the crystallization rate constant (k). These were compared for freshly spray-dried and aged/cry...
Source: Molecules - July 26, 2019 Category: Chemistry Authors: Khadijah Edueng Denny Mahlin Johan Gr åsjö Olivia Nylander Manish Thakrani Christel A.S. Bergstr öm Tags: Article Source Type: research

Assessment of adherence to antihypertensive drugs in patients with resistant hypertension receiving optimal treatment
ConclusionsIn our study, more than two out of three patients with apparent resistant hypertension optimally treated and without white coat effect, were partially or completely non-adherent to treatment. Assessment of treatment adherence in these high cardiovascular risk patients should be systematically implemented and if possible by more objective methods. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research

Improving Diabetic Retinopathy Outcomes: FIELD Fenofibrate.
Authors: Kalra S, Sahay R Abstract This brief communication describes evidence which proves the beneficial effects of fenofibrate on the retinal vasculature in type 2 diabetes, acting via both lipid lowering and non-lipid lowering mechanisms. It discusses data from FIELD and other trials to support the use of fenofibrate as a secondary preventive therapy for diabetic retinopathy. These data contrast with the lack of retinal benefit shown in major cardiovascular outcome trials of other blood pressure lowering and glucose lowering agents such as empagliflozin, liraglutide, perindopril + indapamide, and ramipril. ...
Source: Journal of the Association of Physicians of India - July 18, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Resistant Hypertension Management: Comparison of the 2017 American and 2018 European High Blood Pressure Guidelines
AbstractPurpose of ReviewTo compare European and American guidelines for the diagnosis, evaluation, and management of resistant hypertension.Recent FindingsResistant hypertension is defined as high blood pressure that remains above goal with the use of 3 or more antihypertensive agents, commonly a renin-angiotensin blocker (either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker), a long-acting calcium channel blocker, and thiazide or thiazide-like diuretic. Resistant hypertension is common, with a recent analysis indicating that it affects approximately 17 –19% of adult Americans with hy...
Source: Current Hypertension Reports - July 17, 2019 Category: Primary Care Source Type: research

Redefining diuretics use in hypertension: why select a thiazide-like diuretic?
Diuretics are listed in hypertension guidelines as one of three equally weighted first-line treatment options. In order to differentiate between antihypertensives, a lot of discussion has been directed at side effect profiles and as a result, has created a perhaps disproportionate fear of the metabolic effects that can be associated with diuretics. Data, however, show that the risk of a clinically meaningful change in laboratory parameters is very low, whereas the benefits of volume control and natriuresis are high and the reductions in morbidity and mortality are clinically significant. Moreover, as clinically significant...
Source: Journal of Hypertension - June 27, 2019 Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research

HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments
Publication date: July 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 5Author(s): Eyad Rashed Dawud, Ashok K. ShakyaAbstractA simple, rapid, precise, accurate and sensitive high performance liquid chromatographic method has been developed for simultaneous determination of ACE inhibitors with hydrochlorothiazide and indapamide in pharmaceutical formulations. ‘Design of Experiments’ (DoE) using ‘central composite design’ (CCD) was applied to facilitate method development and optimization. Mobile phase was optimized utilizing response surface methodology using Design Expert software. Chroma...
Source: Arabian Journal of Chemistry - June 22, 2019 Category: Chemistry Source Type: research

Development of High-Strength Extended-Release Multiparticulate System by Crystallo-co-agglomeration Technique with Integration of Central Composite Design.
Abstract The number of unit operations to be followed in the preparation of tablets was cumbersome and may introduce material as well as process-related critical parameters which may negatively affect the quality of final formulation. The hypothesis of the present research was to develop directly compressible, high-strength extended-release spherical agglomerates of talc containing indapamide by crystallo-co-agglomeration technique. Hydroxypropyl methylcellulose 15 cps and polyethylene glycol 6000 were used to impart the desired sphericity, strength, and deformability to agglomerates, respectively. Ethyl cell...
Source: AAPS PharmSciTech - May 20, 2019 Category: Drugs & Pharmacology Authors: Gaikwad VL, Jadhav NR, Pawar AP, Mahadik KR Tags: AAPS PharmSciTech Source Type: research

Molecules, Vol. 24, Pages 1764: A Deeper Investigation of Drug Degradation Mixtures Using a Combination of MS and NMR Data: Application to Indapamide
enaud Alain Petit Serge Pilard A global approach that is based on a combination of mass spectrometry (MS) and nuclear magnetic resonance (NMR) data has been developed for a complete and rapid understanding of drug degradation mixtures. We proposed a workflow based on a sample preparation protocol that is compatible to MS and NMR, the selection of the most appropriate experiments for each technique, and the implementation of prediction software and multivariable analysis method for a better interpretation and correlation of MS and NMR spectra. We have demonstrated the efficient quantification of the remaining active...
Source: Molecules - May 6, 2019 Category: Chemistry Authors: C écile Palaric Roland Molini é Dominique Cailleu Jean-Xavier Fontaine David Mathiron Fran çois Mesnard Yoann Gut Tristan Renaud Alain Petit Serge Pilard Tags: Article Source Type: research

Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
CrystEngComm, 2019,21,2043-2048 DOI: 10.1039/C8CE01075G, CommunicationSuryanarayana Allu, Kuthuru Suresh, Geetha Bolla, M. K. Chaitanya Mannava, Ashwini Nangia Crystalline and amorphous stable binary compounds of indapamide for high solubility and permeability. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - March 25, 2019 Category: Chemistry Authors: Suryanarayana Allu Source Type: research

Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
Publication date: Available online 23 February 2019Source: International Journal of PharmaceuticsAuthor(s): Marwah Aljohani, Pól MacFhionnghaile, Patrick McArdle, Andrea ErxlebenAbstractThe antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent hypertension. Cocrystallization and coamorphization are attractive strategies to enhance dissolution rates and to reduce the number of medications a patient has to take. In this work the formation of cocrystals and coam...
Source: International Journal of Pharmaceutics - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Effectiveness and Adherence to Treatment with Perindopril/Indapamide/Amlodipine Single-Pill Combination in a Greek Population with Hypertension
AbstractBackgroundDespite the overwhelming evidence and the established benefits of antihypertensive treatment, adherence to treatment remains low.ObjectiveTo assess the adherence to treatment with a perindopril/indapamide/amlodipine single-pill combination (SPC), its effectiveness on blood pressure (BP) reduction, as well as the safety and tolerability of this SPC over a 4-month treatment period.MethodsThis multicenter, non-interventional study prospectively included 2285 hypertensive patients on perindopril/indapamide/amlodipine SPC. The data were recorded at baseline, 1  month, and 4 months.ResultsOf the 2285 ...
Source: Clinical Drug Investigation - February 21, 2019 Category: Drugs & Pharmacology Source Type: research

Heat capacity and enthalpy of indapamide
Publication date: Available online 30 January 2019Source: Thermochimica ActaAuthor(s): M. Skotnicki, A. Drogoń, J.J Calvin, P.F Rosen, B.F Woodfield, M PydaAbstractThe heat capacities and total enthalpy of anhydrous indapamide (IND, CAS no.: 26807-65-8) are reported from temperature 1.84 to 523.15 K measured by a Quantum Design Physical Property Measurement System® (PPMS) and differential scanning calorimetry (DSC). The low-temperature experimental heat capacities of crystalline IND from 1.84 to 302.65 K were measured by PPMS and fit to a theoretical model in the low temperature range (T 
Source: Thermochimica Acta - January 30, 2019 Category: Chemistry Source Type: research

'Temporary Plasticiser': A Novel Solution to Fabricate 3D Printed Patient-Centred Cardiovascular 'Polypill' Architectures.
Abstract Hypertension and dyslipidaemia are modifiable risk factors associated with cardiovascular diseases (CVDs) and often require a complex therapeutic regimen. The administration of several medicines is commonly associated with poor levels of adherence among patients, to which World Health Organisation (WHO) proposed a fixed-dose combination unit (polypill) as a strategy to improve adherence. In this work, we demonstrate the fabrication of patient-specific polypills for the treatment of CVDs by fused deposition modelling (FDM) 3D printing and introduce a novel solution to meet critical quality attributes. The ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 20, 2018 Category: Drugs & Pharmacology Authors: Pereira BC, Isreb A, Forbes RT, Dores F, Habashy R, Petit JB, Alhnan MA, Oga E Tags: Eur J Pharm Biopharm Source Type: research

Management of vulval melanoma in situ with imiquimod.
This article is protected by copyright. All rights reserved. PMID: 30430545 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: Veraitch O, Lewis F, Craythorne E, Calonje E, Nath R Tags: Br J Dermatol Source Type: research

Management of vulval melanoma in situ with imiquimod
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: O. Veraitch, F. Lewis, E. Craythorne, E. Calonje, R. Nath Tags: Research Letter Source Type: research

Perindopril/indapamide
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of indapamide versus bendroflumethiazide for primary hypertension: a systematic review
British Journal of Clinical Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - October 12, 2018 Category: Drugs & Pharmacology Authors: Tatiana V. Macfarlane, Filippo Pigazzani, Robert W.V. Flynn, Tom M. Macdonald Source Type: research

Combination Antihypertensive Therapy with Perindopril and Indapamide in Patients with Essential Hypertension: Effect on Endothelial and Cognitive Markers of Vascular Improvement
The objective of this study was to assess the impact of a single-pill combination (SPC) of perindopril/indapamide (PER/IND) at full doses (10/2.5 mg) on endothelial and cognitive function as a clinical intermediate marker of vascular improvement.MethodsThis open-label, uncontrolled, observational study enrolled 30 patients (20 females and 10 males) with grade II –III uncontrolled arterial hypertension (SBP/DBP ≥ 160/100 mmHg) and no evidence of cerebrovascular disease. All patients underwent assessment of macro- and microvascular endothelial function parameters at baseline and after 12 months of treatment wit...
Source: Advances in Therapy - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium ‐sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta‐analysis
The Journal of Clinical Hypertension, EarlyView. (Source: The Journal of Clinical Hypertension)
Source: The Journal of Clinical Hypertension - September 25, 2018 Category: Cardiology Authors: George C. Roush, Ramy Abdelfattah, Steven Song, Michael E. Ernst, Domenic A. Sica, John B. Kostis Source Type: research

Combination Antihypertensive Therapy with Perindopril and Indapamide in Patients with Essential Hypertension: Effect on Endothelial and Cognitive Markers of Vascular Improvement
The objective of this study was to assess the impact of a single-pill combination (SPC) of perindopril/indapamide (PER/IND) at full doses (10/2.5 mg) on endothelial and cognitive function as a clinical intermediate marker of vascular improvement.MethodsThis open-label, uncontrolled, observational study enrolled 30 patients (20 females and 10 males) with grade II –III uncontrolled arterial hypertension (SBP/DBP ≥ 160/100 mmHg) and no evidence of cerebrovascular disease. All patients underwent assessment of macro- and microvascular endothelial function parameters at baseline and after 12 months of treatment wit...
Source: Advances in Therapy - August 20, 2018 Category: Drugs & Pharmacology Source Type: research

Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
CrystEngComm, 2018, Advance Article DOI: 10.1039/C8CE01075G, CommunicationSuryanarayana Allu, Kuthuru Suresh, Geetha Bolla, M. K. Chaitanya Mannava, Ashwini Nangia Crystalline and amorphous stable binary compounds of indapamide for high solubility and permeability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 17, 2018 Category: Chemistry Authors: Suryanarayana Allu Source Type: research

Role of hydrogen bonding in cocrystal and coamorphous solids: Indapamide as a case study
CrystEngComm, 2018, Accepted Manuscript DOI: 10.1039/C8CE01075G, CommunicationAshwini Nangia, Suryanarayana Allu, Kuthuru Suresh, Geetha Bolla, Chaitanya Mannava The stronger sulfonamide-pyridine (SO2NH2 •••N-Py) and sulfonamide-carboxamide (SO2NH2•••O=C-NH) hydrogen bonding directs the formation of cocrystals while weaker sulfonamide-amine (SO2NH2•••N-H) hydrogen bond results in coamorphous products. IDP-PIP and IDP-ARG coamorphous solids exhibit... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 7, 2018 Category: Chemistry Authors: Ashwini Nangia Source Type: research

Contribution of Volume Overload to Progression of Cardiovascular Diseases in Rat Model of Chronic Kidney Disease.
In conclusion, salt induced volume overload in a rat model of CKD had an adverse cardiovascular outcome and it was associated with inflammatory activation and decrease in renal klotho expression. PMID: 30079760 [PubMed - as supplied by publisher] (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - August 4, 2018 Category: Drugs & Pharmacology Authors: Mahmoud MM, Shamseldeen A, Rashed LA, Fares AE, Shamaa A, Gharib DM Tags: Can J Physiol Pharmacol Source Type: research