Cardiac arrhythmia triggered by diuretic-induced hyponatremia.
We present an unusual case of indapamide-induced hyponatremia and hypokalemia complicated by cardiac arrhythmia. The adverse drug reaction was reversible and non-life-threatening, but this case serves as a reminder that careful evaluation and constant monitoring are necessary when prescribing diuretics. PMID: 31827736 [PubMed] (Source: American Family Physician)
Source: American Family Physician - December 14, 2019 Category: Primary Care Authors: Lu HT, Loo HC, Ng KS, Wong YO, Nordin R Tags: Malays Fam Physician Source Type: research

GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
Publication date: Available online 28 November 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Olga Begou, Kathrin Drabert, Georgios Theodoridis, Dimitrios TsikasAbstractAcetazolamide (molecular mass (MM), 222) belongs to the class of sulfonamides (R-SO2-NH2) and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity. Acetazolamide is excreted unchanged in the urine. Here, we report on the development, validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human urine. The method is based on evaporat...
Source: Journal of Pharmaceutical Analysis - November 29, 2019 Category: Drugs & Pharmacology Source Type: research

Unravelling the inhibitory and cytoprotective potential of diuretics towards amyloid fibrillation.
Abstract Protein misfolding and deposition of aggregated proteins inside as well as outside of the cells have been associated with several neurotoxic and neurodegenerative disorders like Alzheimer's, Parkinson's and familial amyloid polyneuropathy etc. that could be controlled by anti-aggregation methodologies employing either inhibition or disaggregation of toxic aggregates. Also, the Alzheimer's disease develops in later life is somehow related to the high mid-life blood pressure. Therefore the present work targets the amyloid inhibiting potential of diuretics (a class of antihypertensive drugs) - Indapamide (IN...
Source: International Journal of Biological Macromolecules - November 16, 2019 Category: Biochemistry Authors: Malik S, Khursheed Siddiqi M, Majid N, Masroor A, Moasfar Ali S, Khan RH Tags: Int J Biol Macromol Source Type: research

Feasibility of 24-h central blood pressure monitoring: experience from multinational clinical trial assessing the efficacy of perindopril/indapamide/amlodipine
Objectives: Brachial blood pressure (BP) is a predictor of cardiovascular events. Evidence suggests that central BP (CBP) provides additional information for cardiovascular risk assessment. Methods to assess 24-h CBP are now available. Our objective was to assess the feasibility of 24-h CBP monitoring in clinical trials and its ability for drug evaluation. Methods: Data are issued from an international phase 3 randomized clinical trial comparing the efficacy of perindopril/indapamide/amlodipine vs. perindopril/indapamide (Per/Ind), in uncontrolled hypertensive patients treated with Per/Ind. 24-h ambulatory BP monitori...
Source: Journal of Hypertension - November 4, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: BP measurement and hemodynamic aspects Source Type: research

Simultaneous Evaluation of Dissolution and Permeation of Oral Drug Solid Formulations for Predicting Absorption Rate-Limiting Factors and In Vitro-In Vivo Correlations: Case Study Using a Poorly Soluble Weakly Basic Drug.
In this study, the modified biorelevant media with some solubilizers and pH modifiers were integrated into the drug dissolution/absorption simulating system (DDASS). Indapamide, a poorly soluble compound (pKa = 8.8), was selected to validate the applicability of the modified biorelevant media. The elution and permeation dynamics of indapamide were investigated by using appropriate solubilizing agents in the DDASS. The absorption behaviors were analyzed after oral administration of indapamide in beagle dogs. The absorption rate-limiting steps and IVIVCs were predicted from the dissolution-permeation-absorption dynamic param...
Source: AAPS PharmSciTech - October 24, 2019 Category: Drugs & Pharmacology Authors: Li Z, He X, Tian S, Feng G, Huang C, Xun M, Wu Z, Wang Y Tags: AAPS PharmSciTech Source Type: research

Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects
Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Alberto Mazza, Danyelle M. Townsend, Laura Schiavon, Gioia Torin, Salvatore Lenti, Ciro Rossetti, Gianluca Rigatelli, Domenico RubelloAbstractBackgroundMost antihypertensive drugs used in monotherapy or in combination therapy reduce the left ventricular mass index (LVMI). However, little is known about the effects on LVMI of a triple fixed-dose combination (TFC) therapy, containing in a single pill an angiotensin-converting enzyme inhibitor (ACEI), a diuretic and a calcium channel blocker (CCB).MethodsIn this prospective open-lab...
Source: Biomedicine and Pharmacotherapy - October 17, 2019 Category: Drugs & Pharmacology Source Type: research

Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects.
Abstract BACKGROUND: Most antihypertensive drugs used in monotherapy or in combination therapy reduce the left ventricular mass index (LVMI). However, little is known about the effects on LVMI of a triple fixed-dose combination (TFC) therapy, containing in a single pill an angiotensin-converting enzyme inhibitor (ACEI), a diuretic and a calcium channel blocker (CCB). METHODS: In this prospective open-label study, 92 patients with essential hypertension were randomized to treatment with a TFC of perindopril/indapamide/amlodipine at different doses or a triple free combination therapy (FCT) including ACEI/diure...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2019 Category: Drugs & Pharmacology Authors: Mazza A, Townsend DM, Schiavon L, Torin G, Lenti S, Rossetti C, Rigatelli G, Rubello D Tags: Biomed Pharmacother Source Type: research

Efficacy of a new single-pill combination of a thiazide-like diuretic and a calcium channel blocker (indapamide sustained release/amlodipine) in essential hypertension
Objectives: The current international, 12-week, double-blind, randomized, controlled trial assessed the efficacy and safety of indapamide sustained release/amlodipine single-pill combination (SPC) in mild-to-moderate hypertensive patients. Methods: Following a 4-week run-in period on amlodipine 5 mg, patients (SBP 150–180 mmHg and/or DBP  (Source: Journal of Hypertension)
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Evaluation of Clinical Acceptability of Perindopril / Indapamide Single-pill Combination in Moderate to Severe Hypertension.
In this study, 173 hypertensive patients, with a mean age of 51 years were enrolled at 3 centres from different geographic areas within India. Mean SBP/DBP decreased significantly from baseline (155.70 (±10.39) / 95.72 (±6.99) mmHg) over 90 days (30.31 (±14.15) / 17.14 (±9.33) mmHg; p
Source: Journal of the Association of Physicians of India - September 30, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Molecules, Vol. 24, Pages 2731: Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage
This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active pharmaceutical ingredients (APIs). Spray-dried, fully amorphous indapamide, metolazone, glibenclamide, hydrocortisone, hydrochlorothiazide, ketoconazole, and sulfathiazole were used as model APIs. The parameters used to assess the supersaturation potential and crystallization kinetics were the maximum supersaturation concentration (Cmax,app), the area under the curve (AUC), and the crystallization rate constant (k). These were compared for freshly spray-dried and aged/cry...
Source: Molecules - July 27, 2019 Category: Chemistry Authors: Khadijah Edueng Denny Mahlin Johan Gr åsjö Olivia Nylander Manish Thakrani Christel A.S. Bergstr öm Tags: Article Source Type: research

Assessment of adherence to antihypertensive drugs in patients with resistant hypertension receiving optimal treatment
ConclusionsIn our study, more than two out of three patients with apparent resistant hypertension optimally treated and without white coat effect, were partially or completely non-adherent to treatment. Assessment of treatment adherence in these high cardiovascular risk patients should be systematically implemented and if possible by more objective methods. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research

Improving Diabetic Retinopathy Outcomes: FIELD Fenofibrate.
Authors: Kalra S, Sahay R Abstract This brief communication describes evidence which proves the beneficial effects of fenofibrate on the retinal vasculature in type 2 diabetes, acting via both lipid lowering and non-lipid lowering mechanisms. It discusses data from FIELD and other trials to support the use of fenofibrate as a secondary preventive therapy for diabetic retinopathy. These data contrast with the lack of retinal benefit shown in major cardiovascular outcome trials of other blood pressure lowering and glucose lowering agents such as empagliflozin, liraglutide, perindopril + indapamide, and ramipril. ...
Source: Journal of the Association of Physicians of India - July 18, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Resistant Hypertension Management: Comparison of the 2017 American and 2018 European High Blood Pressure Guidelines
AbstractPurpose of ReviewTo compare European and American guidelines for the diagnosis, evaluation, and management of resistant hypertension.Recent FindingsResistant hypertension is defined as high blood pressure that remains above goal with the use of 3 or more antihypertensive agents, commonly a renin-angiotensin blocker (either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker), a long-acting calcium channel blocker, and thiazide or thiazide-like diuretic. Resistant hypertension is common, with a recent analysis indicating that it affects approximately 17 –19% of adult Americans with hy...
Source: Current Hypertension Reports - July 18, 2019 Category: Primary Care Source Type: research

Redefining diuretics use in hypertension: why select a thiazide-like diuretic?
Diuretics are listed in hypertension guidelines as one of three equally weighted first-line treatment options. In order to differentiate between antihypertensives, a lot of discussion has been directed at side effect profiles and as a result, has created a perhaps disproportionate fear of the metabolic effects that can be associated with diuretics. Data, however, show that the risk of a clinically meaningful change in laboratory parameters is very low, whereas the benefits of volume control and natriuresis are high and the reductions in morbidity and mortality are clinically significant. Moreover, as clinically significant...
Source: Journal of Hypertension - June 27, 2019 Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research

HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments
Publication date: July 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 5Author(s): Eyad Rashed Dawud, Ashok K. ShakyaAbstractA simple, rapid, precise, accurate and sensitive high performance liquid chromatographic method has been developed for simultaneous determination of ACE inhibitors with hydrochlorothiazide and indapamide in pharmaceutical formulations. ‘Design of Experiments’ (DoE) using ‘central composite design’ (CCD) was applied to facilitate method development and optimization. Mobile phase was optimized utilizing response surface methodology using Design Expert software. Chroma...
Source: Arabian Journal of Chemistry - June 22, 2019 Category: Chemistry Source Type: research

Development of High-Strength Extended-Release Multiparticulate System by Crystallo-co-agglomeration Technique with Integration of Central Composite Design.
Abstract The number of unit operations to be followed in the preparation of tablets was cumbersome and may introduce material as well as process-related critical parameters which may negatively affect the quality of final formulation. The hypothesis of the present research was to develop directly compressible, high-strength extended-release spherical agglomerates of talc containing indapamide by crystallo-co-agglomeration technique. Hydroxypropyl methylcellulose 15 cps and polyethylene glycol 6000 were used to impart the desired sphericity, strength, and deformability to agglomerates, respectively. Ethyl cell...
Source: AAPS PharmSciTech - May 21, 2019 Category: Drugs & Pharmacology Authors: Gaikwad VL, Jadhav NR, Pawar AP, Mahadik KR Tags: AAPS PharmSciTech Source Type: research

Molecules, Vol. 24, Pages 1764: A Deeper Investigation of Drug Degradation Mixtures Using a Combination of MS and NMR Data: Application to Indapamide
enaud Alain Petit Serge Pilard A global approach that is based on a combination of mass spectrometry (MS) and nuclear magnetic resonance (NMR) data has been developed for a complete and rapid understanding of drug degradation mixtures. We proposed a workflow based on a sample preparation protocol that is compatible to MS and NMR, the selection of the most appropriate experiments for each technique, and the implementation of prediction software and multivariable analysis method for a better interpretation and correlation of MS and NMR spectra. We have demonstrated the efficient quantification of the remaining active...
Source: Molecules - May 7, 2019 Category: Chemistry Authors: C écile Palaric Roland Molini é Dominique Cailleu Jean-Xavier Fontaine David Mathiron Fran çois Mesnard Yoann Gut Tristan Renaud Alain Petit Serge Pilard Tags: Article Source Type: research

Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
CrystEngComm, 2019,21,2043-2048 DOI: 10.1039/C8CE01075G, CommunicationSuryanarayana Allu, Kuthuru Suresh, Geetha Bolla, M. K. Chaitanya Mannava, Ashwini Nangia Crystalline and amorphous stable binary compounds of indapamide for high solubility and permeability. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - March 25, 2019 Category: Chemistry Authors: Suryanarayana Allu Source Type: research

Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
Publication date: Available online 23 February 2019Source: International Journal of PharmaceuticsAuthor(s): Marwah Aljohani, Pól MacFhionnghaile, Patrick McArdle, Andrea ErxlebenAbstractThe antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent hypertension. Cocrystallization and coamorphization are attractive strategies to enhance dissolution rates and to reduce the number of medications a patient has to take. In this work the formation of cocrystals and coam...
Source: International Journal of Pharmaceutics - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Effectiveness and Adherence to Treatment with Perindopril/Indapamide/Amlodipine Single-Pill Combination in a Greek Population with Hypertension
AbstractBackgroundDespite the overwhelming evidence and the established benefits of antihypertensive treatment, adherence to treatment remains low.ObjectiveTo assess the adherence to treatment with a perindopril/indapamide/amlodipine single-pill combination (SPC), its effectiveness on blood pressure (BP) reduction, as well as the safety and tolerability of this SPC over a 4-month treatment period.MethodsThis multicenter, non-interventional study prospectively included 2285 hypertensive patients on perindopril/indapamide/amlodipine SPC. The data were recorded at baseline, 1  month, and 4 months.ResultsOf the 2285 ...
Source: Clinical Drug Investigation - February 21, 2019 Category: Drugs & Pharmacology Source Type: research

Heat capacity and enthalpy of indapamide
Publication date: Available online 30 January 2019Source: Thermochimica ActaAuthor(s): M. Skotnicki, A. Drogoń, J.J Calvin, P.F Rosen, B.F Woodfield, M PydaAbstractThe heat capacities and total enthalpy of anhydrous indapamide (IND, CAS no.: 26807-65-8) are reported from temperature 1.84 to 523.15 K measured by a Quantum Design Physical Property Measurement System® (PPMS) and differential scanning calorimetry (DSC). The low-temperature experimental heat capacities of crystalline IND from 1.84 to 302.65 K were measured by PPMS and fit to a theoretical model in the low temperature range (T 
Source: Thermochimica Acta - January 30, 2019 Category: Chemistry Source Type: research

'Temporary Plasticiser': A Novel Solution to Fabricate 3D Printed Patient-Centred Cardiovascular 'Polypill' Architectures.
Abstract Hypertension and dyslipidaemia are modifiable risk factors associated with cardiovascular diseases (CVDs) and often require a complex therapeutic regimen. The administration of several medicines is commonly associated with poor levels of adherence among patients, to which World Health Organisation (WHO) proposed a fixed-dose combination unit (polypill) as a strategy to improve adherence. In this work, we demonstrate the fabrication of patient-specific polypills for the treatment of CVDs by fused deposition modelling (FDM) 3D printing and introduce a novel solution to meet critical quality attributes. The ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 20, 2018 Category: Drugs & Pharmacology Authors: Pereira BC, Isreb A, Forbes RT, Dores F, Habashy R, Petit JB, Alhnan MA, Oga E Tags: Eur J Pharm Biopharm Source Type: research

Management of vulval melanoma in situ with imiquimod
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: O. Veraitch, F. Lewis, E. Craythorne, E. Calonje, R. Nath Tags: Research Letter Source Type: research

Management of vulval melanoma in situ with imiquimod.
This article is protected by copyright. All rights reserved. PMID: 30430545 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: Veraitch O, Lewis F, Craythorne E, Calonje E, Nath R Tags: Br J Dermatol Source Type: research

Perindopril/indapamide
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of indapamide versus bendroflumethiazide for primary hypertension: a systematic review
British Journal of Clinical Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - October 12, 2018 Category: Drugs & Pharmacology Authors: Tatiana V. Macfarlane, Filippo Pigazzani, Robert W.V. Flynn, Tom M. Macdonald Source Type: research

Combination Antihypertensive Therapy with Perindopril and Indapamide in Patients with Essential Hypertension: Effect on Endothelial and Cognitive Markers of Vascular Improvement
The objective of this study was to assess the impact of a single-pill combination (SPC) of perindopril/indapamide (PER/IND) at full doses (10/2.5 mg) on endothelial and cognitive function as a clinical intermediate marker of vascular improvement.MethodsThis open-label, uncontrolled, observational study enrolled 30 patients (20 females and 10 males) with grade II –III uncontrolled arterial hypertension (SBP/DBP ≥ 160/100 mmHg) and no evidence of cerebrovascular disease. All patients underwent assessment of macro- and microvascular endothelial function parameters at baseline and after 12 months of treatment wit...
Source: Advances in Therapy - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium ‐sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta‐analysis
The Journal of Clinical Hypertension, EarlyView. (Source: The Journal of Clinical Hypertension)
Source: The Journal of Clinical Hypertension - September 25, 2018 Category: Cardiology Authors: George C. Roush, Ramy Abdelfattah, Steven Song, Michael E. Ernst, Domenic A. Sica, John B. Kostis Source Type: research

Combination Antihypertensive Therapy with Perindopril and Indapamide in Patients with Essential Hypertension: Effect on Endothelial and Cognitive Markers of Vascular Improvement
The objective of this study was to assess the impact of a single-pill combination (SPC) of perindopril/indapamide (PER/IND) at full doses (10/2.5 mg) on endothelial and cognitive function as a clinical intermediate marker of vascular improvement.MethodsThis open-label, uncontrolled, observational study enrolled 30 patients (20 females and 10 males) with grade II –III uncontrolled arterial hypertension (SBP/DBP ≥ 160/100 mmHg) and no evidence of cerebrovascular disease. All patients underwent assessment of macro- and microvascular endothelial function parameters at baseline and after 12 months of treatment wit...
Source: Advances in Therapy - August 20, 2018 Category: Drugs & Pharmacology Source Type: research

Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
CrystEngComm, 2018, Advance Article DOI: 10.1039/C8CE01075G, CommunicationSuryanarayana Allu, Kuthuru Suresh, Geetha Bolla, M. K. Chaitanya Mannava, Ashwini Nangia Crystalline and amorphous stable binary compounds of indapamide for high solubility and permeability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 17, 2018 Category: Chemistry Authors: Suryanarayana Allu Source Type: research

Role of hydrogen bonding in cocrystal and coamorphous solids: Indapamide as a case study
CrystEngComm, 2018, Accepted Manuscript DOI: 10.1039/C8CE01075G, CommunicationAshwini Nangia, Suryanarayana Allu, Kuthuru Suresh, Geetha Bolla, Chaitanya Mannava The stronger sulfonamide-pyridine (SO2NH2 •••N-Py) and sulfonamide-carboxamide (SO2NH2•••O=C-NH) hydrogen bonding directs the formation of cocrystals while weaker sulfonamide-amine (SO2NH2•••N-H) hydrogen bond results in coamorphous products. IDP-PIP and IDP-ARG coamorphous solids exhibit... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 7, 2018 Category: Chemistry Authors: Ashwini Nangia Source Type: research

Contribution of Volume Overload to Progression of Cardiovascular Diseases in Rat Model of Chronic Kidney Disease.
In conclusion, salt induced volume overload in a rat model of CKD had an adverse cardiovascular outcome and it was associated with inflammatory activation and decrease in renal klotho expression. PMID: 30079760 [PubMed - as supplied by publisher] (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - August 4, 2018 Category: Drugs & Pharmacology Authors: Mahmoud MM, Shamseldeen A, Rashed LA, Fares AE, Shamaa A, Gharib DM Tags: Can J Physiol Pharmacol Source Type: research

Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application
Publication date: Available online 19 May 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Yi Tao, Sheng Wang, Lei Wang, Min Song, Taijun HangAbstractSimple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Indapamide-d3, perindopril-d4 and perindoprilat-d4 were used as the internal standards. The separation was performed on a Thermo BDS Hypersil C18 column (4.6 mm×100 mm, 2.4 μm) for indapamide and perindo...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application
Publication date: Available online 19 May 2018 Source:Journal of Pharmaceutical Analysis Author(s): Yi Tao, Sheng Wang, Lei Wang, Min Song, Taijun Hang Simple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Indapamide-d3, perindopril-d4 and perindoprilat-d4 were used as the internal standards. The separation was performed on a Thermo BDS Hypersil C18 column (4.6mm×100mm, 2.4 μm) for indapamide and perindopril simultaneous...
Source: Journal of Pharmaceutical Analysis - May 20, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and Tolerability of Fixed-Dose Combination Perindopril/Indapamide in Hypertensive Patients with a History of Stroke or Transient Ischemic Attack: PICASSO Trial
AbstractIntroductionIn everyday medical practice, physicians often need to manage patients whose blood pressure is not well controlled. Those with a history of cerebrovascular disease are a high-risk group in need of rapid blood pressure control.MethodsThe PICASSO study was a real-life, observational trial involving 9257 inadequately treated hypertensive patients who were switched from previous therapy to the fixed-dose combination of perindopril 10  mg/indapamide 2.5 mg (PI) for 3 months. A subanalysis of data of 1117 hypertensive patients who met the clinical criteria of previous stroke or transient ischem...
Source: Advances in Therapy - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Hydrochlorothiazide and alternative diuretics versus renin–angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis
Background: Found in 36–41% of hypertension, elevated left ventricular mass (LVM) independently predicts cardiovascular events and total mortality. Conversely, drug-induced regression of LVM predicts improved outcomes. Previous studies have favored renin–angiotensin system inhibitors (RASIs) over other antihypertensives for reducing LVM but ignored differences among thiazide-type diuretics. From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that ‘CHIP’ diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: Reviews Source Type: research

Type 2 Diabetes and Thiazide Diuretics
AbstractPurpose of ReviewIn patients with prediabetes or type 2 diabetes, the use of thiazides as antihypertensive agents has been challenged because associated metabolic adverse events, including new-onset diabetes.Recent FindingsThese metabolic disturbances are less marked with low-dose thiazides and, in most but not all studies, with thiazide-like diuretics (chlorthalidone, indapamide) than with thiazide-type diuretics (hydrochlorothiazide). In post hoc analyses of subgroups of patients with hypertension and type 2 diabetes, thiazides resulted in a significant reduction in cardiovascular events, all-cause mortality, and...
Source: Current Diabetes Reports - February 5, 2018 Category: Endocrinology Source Type: research

Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes.
CONCLUSION: Moving forward, understanding the pathophysiological bases of the effects that extend beyond those of blood pressure control, will help us differentiate between anti-hypertensive choices. PMID: 29307229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Diagnosis and management of hyponatraemia in the older patient
Abstract Hyponatraemia (serum sodium concentration below 135 mmol/L) is the most common electrolyte disturbance and occurs commonly in older people. The causes can be complex to diagnose and treat and many published guidelines do not focus on the issues in an older patient group. Here, we are principally concerned with diagnosis and management of euvolaemic and hypervolaemic hyponatraemia in hospitalised patients over 70 years old. We also aim to increase awareness of hyponatraemia in residential aged care facilities and the community. Hyponatraemia can have many causes; in older people, chronic hyponatraemia can often be ...
Source: Internal Medicine Journal - January 10, 2018 Category: Internal Medicine Authors: Michael Woodward, Peter Gonski, Mathis Grossmann, John Obeid, Ron Scholes, Duncan J. Topliss Tags: Review Source Type: research

Resistant hypertension: an overview.
Authors: Pedrinelli R, Dell' Omo G, Ambrosio G, Cameli M, Cerbai E, Coiro S, Emdin M, Liga R, Marcucci R, Morrone D, Palazzuoli A, Padeletti L, Savino K, Società Italiana di Cardiologia, Sezione Regionale Tosco-Umbra Abstract Despite the availability of anti-hypertensive medications with proven efficacy and good tolerability, many hypertensive patients have blood pressure levels(BP) not at the goals set by international societies. Some of these patients are either non-adherent to the prescribed drugs or not optimally treated. However, a proportion, despite adequate treatment, has resistant hypertension(RH) d...
Source: Minerva Cardioangiologica - September 9, 2017 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Blood pressure –lowering efficacy of indapamide SR/amlodipine combination in older patients with hypertension: A post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria)
To examine the antihypertensive efficacy and safety of indapamide sustained‐release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted. NESTOR randomized 570 patients (n=197, aged ≥65 years) with hypertension (systolic BP 140–180/diastolic BP
Source: The Journal of Clinical Hypertension - July 18, 2017 Category: Cardiology Authors: Olivier Hanon, Laure Caillard, Edouard Chaussade, Intza Hernandorena, Clemence Boully Tags: ORIGINAL PAPER Source Type: research

Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan
& X Chen (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - July 13, 2017 Category: Cardiology Authors: S Wang J Li X Zhou K Liu X Zhang Q Meng R Shi D Shi X Chen Source Type: research

Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan
Journal of Human Hypertension, Published online: 13 July 2017; doi:10.1038/jhh.2017.51 (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - July 13, 2017 Category: Cardiology Authors: S Wang J Li X Zhou K Liu X Zhang Q Meng R Shi D Shi X Chen Source Type: research

The Transition From Hypertension to  Heart Failure
Publication date: Available online 12 July 2017 Source:JACC: Heart Failure Author(s): Franz H. Messerli, Stefano F. Rimoldi, Sripal Bangalore Longstanding hypertension ultimately leads to heart failure (HF), and as a consequence most patients with HF have a history of hypertension. Conversely, absence of hypertension in middle age is associated with lower risks for incident HF across the remaining life course. Cardiac remodeling to a predominant pressure overload consists of diastolic dysfunction and concentric left ventricular (LV) hypertrophy. When pressure overload is sustained, diastolic dysfunction progresses, f...
Source: JACC: Heart Failure - July 12, 2017 Category: Cardiology Source Type: research

Erratum to: Full-dose Perindopril/Indapamide in the Treatment of Difficult-to-Control Hypertension: The FORTISSIMO Study
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - July 10, 2017 Category: Drugs & Pharmacology Source Type: research

Prospective direct comparison of antihypertensive effect and safety between high-dose amlodipine or indapamide in hypertensive patients uncontrolled by standard doses of angiotensin receptor blockers and amlodipine.
Abstract OBJECTIVE: When hypertension is uncontrolled by routine treatment with an angiotensin II receptor blocker (ARB) and the calcium channel blocker amlodipine (5 mg), the dose of amlodipine can be increased or a diuretic can be added. We investigated the more effective option in a prospective multicenter open-label study. METHODS: Hypertensive patients were recruited if the target blood pressure (BP) in The Japanese Society of Hypertension 2009 guideline could not be achieved with standard-dose ARB therapy and amlodipine (5 mg). PATIENTS: Patients were divided into three groups. Group-1 was switched...
Source: Clinical and Experimental Hypertension - July 10, 2017 Category: Cardiology Authors: Okamura K, Shirai K, Totake N, Okuda T, Urata H Tags: Clin Exp Hypertens Source Type: research

The Antihypertensive Efficacy of the Triple Fixed Combination of Perindopril, Indapamide, and Amlodipine: The Results of the PETRA Study
AbstractIntroductionThe etiology of essential hypertension is multifactorial. Therefore, treatment with combinations of antihypertensive agents acting on multiple targets is necessary for successful therapy in the majority of patients. According to the experience and clinical data accumulated so far, combination therapy with three agents from different pharmacological classes is required in approx. 30% of patients in order to achieve long-term blood pressure control. The primary objective of the PETRA study was to evaluate the efficacy of blood pressure (BP) control with once daily administration of the different dosage st...
Source: Advances in Therapy - June 23, 2017 Category: Drugs & Pharmacology Source Type: research

Comparison of thiazide ‐like diuretics versus thiazide‐type diuretics: a meta‐analysis
Abstract Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide‐type diuretics hydrochlorothiazide and thiazide‐like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta‐analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol. Twelve trials were identified: five ba...
Source: Journal of Cellular and Molecular Medicine - June 19, 2017 Category: Molecular Biology Authors: Wenjing Liang, Hui Ma, Luxi Cao, Wenjiang Yan, Jingjing Yang Tags: Review Source Type: research