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Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial
Publication date: Available online 14 December 2017 Source:The Lancet Author(s): Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin...
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Rifampicin for Staphylococcus aureus bacteraemia: give it ARREST
Publication date: Available online 14 December 2017 Source:The Lancet Author(s): Thomas L Holland, Vance G Fowler (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Timely sensory stimulation and early childhood development
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Bolajoko O Olusanya, Tony Sirimanna, Bradley McPherson (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Targeted-release budesonide therapy for IgA nephropathy – Authors' reply
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Bengt Fellström, Jonathan Barratt, Jürgen Flöge, Alan Jardine (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Targeted-release budesonide therapy for IgA nephropathy
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Kenji Tsuda, Tetsuya Tanimoto, Jinichi Mori, Kazuhiro Kosugi, Tsunehiko Komatsu (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Time for WHO to renew its commitment to health research
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Tikki Pang, Mahmoud Fathalla, Judith Whitworth, Luis-Gabriel Cuervo (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

A call to reinstate Pakistan's death penalty moratorium
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Syed Ibaad Ali, Ariba Khan, Huda Fatima, Syed Ather Hussain (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Joan Bicknell
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Geoff Watts (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

The disaster artists
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Desmond O'Neill (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

They died as they walked
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Richard Barnett (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Elizabeth Garrett Anderson: early pioneer of women in medicine
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Laura Kelly (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

The cost of mass-casualty attacks
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): John Zarocostas (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Public availability of trial protocols
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Morgan Lucey, Jocalyn Clark, Paul Glasziou (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Offline: The unspoken dangers facing UK medical science
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): Richard Horton (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

The balancing act of orphan drug pricing
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Dementia burden coming into focus
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Achieving sustainable solidarity development goals
Publication date: 16–22 December 2017 Source:The Lancet, Volume 390, Issue 10113 Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - December 15, 2017 Category: General Medicine Source Type: research

Challenges in reducing influenza-associated mortality
Publication date: Available online 14 December 2017 Source:The Lancet Author(s): Sheena Sullivan (Source: The Lancet)
Source: The Lancet - December 14, 2017 Category: General Medicine Source Type: research

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
Publication date: Available online 14 December 2017 Source:The Lancet Author(s): A Danielle Iuliano, Katherine M Roguski, Howard H Chang, David J Muscatello, Rakhee Palekar, Stefano Tempia, Cheryl Cohen, Jon Michael Gran, Dena Schanzer, Benjamin J Cowling, Peng Wu, Jan Kyncl, Li Wei Ang, Minah Park, Monika Redlberger-Fritz, Hongjie Yu, Laura Espenhain, Anand Krishnan, Gideon Emukule, Liselotte van Asten, Susana Pereira da Silva, Suchunya Aungkulanon, Udo Buchholz, Marc-Alain Widdowson, Joseph S Bresee Background Estimates of influenza-associated mortality are important for national and international decision making on pub...
Source: The Lancet - December 14, 2017 Category: General Medicine Source Type: research

Tony Capon: the world's first professor of planetary health
Publication date: Available online 12 December 2017 Source:The Lancet Author(s): Tony Kirby (Source: The Lancet)
Source: The Lancet - December 13, 2017 Category: General Medicine Source Type: research

Acalabrutinib in mantle cell lymphoma
Publication date: Available online 11 December 2017 Source:The Lancet Author(s): Prashant Kapoor, Stephen M Ansell (Source: The Lancet)
Source: The Lancet - December 12, 2017 Category: General Medicine Source Type: research

Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial
Publication date: Available online 11 December 2017 Source:The Lancet Author(s): Michael Wang, Simon Rule, Pier Luigi Zinzani, Andre Goy, Olivier Casasnovas, Stephen D Smith, Gandhi Damaj, Jeanette Doorduijn, Thierry Lamy, Franck Morschhauser, Carlos Panizo, Bijal Shah, Andrew Davies, Richard Eek, Jehan Dupuis, Eric Jacobsen, Arnon P Kater, Steven Le Gouill, Lucie Oberic, Taduesz Robak, Todd Covey, Richa Dua, Ahmed Hamdy, Xin Huang, Raquel Izumi, Priti Patel, Wayne Rothbaum, J Greg Slatter, Wojciech Jurczak Background Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) ...
Source: The Lancet - December 12, 2017 Category: General Medicine Source Type: research

Osman Sankoh: better data for better health
Publication date: Available online 8 December 2017 Source:The Lancet Author(s): Geoff Watts (Source: The Lancet)
Source: The Lancet - December 9, 2017 Category: General Medicine Source Type: research

Transparency about the outcomes of mental health services (IAPT approach): an analysis of public data
Publication date: Available online 7 December 2017 Source:The Lancet Author(s): David M Clark, Lauren Canvin, John Green, Richard Layard, Stephen Pilling, Magdalena Janecka Background Internationally, the clinical outcomes of routine mental health services are rarely recorded or reported; however, an exception is the English Improving Access to Psychological Therapies (IAPT) service, which delivers psychological therapies recommended by the National Institute for Health and Care Excellence for depression and anxiety disorders to more than 537 000 patients in the UK each year. A session-by-session outcome monitoring syst...
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Improving access to psychological therapies in England
Publication date: Available online 7 December 2017 Source:The Lancet Author(s): Graham Thornicroft (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

China's Silk Road and global health
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Kun Tang, Zhihui Li, Wenkai Li, Lincoln Chen In 2013, China proposed its Belt and Road Initiative to promote trade, infrastructure, and commercial associations with 65 countries in Asia, Africa, and Europe. This initiative contains important health components. Simultaneously, China launched an unprecedented overseas intervention against Ebola virus in west Africa, dispatching 1200 workers, including Chinese military personnel. The overseas development assistance provided by China has been increasing by 25% annually, reaching U...
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

The primary health-care system in China
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Xi Li, Jiapeng Lu, Shuang Hu, KK Cheng, Jan De Maeseneer, Qingyue Meng, Elias Mossialos, Dong Roman Xu, Winnie Yip, Hongzhao Zhang, Harlan M Krumholz, Lixin Jiang, Shengshou Hu China has made remarkable progress in strengthening its primary health-care system. Nevertheless, the system still faces challenges in structural characteristics, incentives and policies, and quality of care, all of which diminish its preparedness to care for a fifth of the world's population, which is ageing and which has a growing prevalence of chroni...
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Antiplatelet cessation to manage bleeding events in elderly people – Authors' reply
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Linxin Li, Peter M Rothwell (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Antiplatelet cessation to manage bleeding events in elderly people
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Cody Magnusson (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Overestimation of cardiovascular outcome incidence – Authors' reply
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Helmut Schumacher, Felix Mahfoud, Michael Böhm (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Overestimation of cardiovascular outcome incidence
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Yuanzi Ye, Ricardo Fonseca (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Anonymity in HIV testing: implications for public health
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Edson Luis Bernardo, Laura Fuente-Soro, Elisa Lopez-Varela, Denise Naniche (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Political determinants of Sustainable Development Goals
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Camila Gianella, Marta Rodriguez de Assis Machado, Siri Gloppen (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Health-care delivery for long-term survivors of childhood cancer
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Gregory J Aune (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Icarus
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Athar Yawar (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Hospital histories
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Margaret McCartney (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Qimin Zhan: driving medical research for better health in China
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Rachael Davies (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Millions in need of humanitarian assistance in Yemen
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Sharmila Devi (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Phage therapy: revival of the bygone antimicrobial
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Geoff Watts (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Offline: The tasks facing Dr Tedros
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): Richard Horton (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

When a hospital becomes a prison
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Family planning: accelerating the way ahead
Publication date: 9–15 December 2017 Source:The Lancet, Volume 390, Issue 10112 Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - December 8, 2017 Category: General Medicine Source Type: research

Atraumatic lumbar puncture needles: practice needs to change
Publication date: Available online 7 December 2017 Source:The Lancet Author(s): Diederik van de Beek, Matthijs C Brouwer (Source: The Lancet)
Source: The Lancet - December 7, 2017 Category: General Medicine Source Type: research

Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis
This study is registered with the International Prospective Register of Systematic Reviews, number CRD42016047546. Findings We identified 20 241 reports; after exclusions, 110 trials done between 1989 and 2017 from 29 countries, including a total of 31 412 participants, were eligible for analysis. The incidence of postdural-puncture headache was significantly reduced from 11·0% (95% CI 9·1–13·3) in the conventional needle group to 4·2% (3·3–5·2) in the atraumatic group (relative risk 0·40, 95% CI 0·34–0·47, p<0·0001; I 2=45&m...
Source: The Lancet - December 7, 2017 Category: General Medicine Source Type: research

Walking to a pathway for cardiovascular effects of air pollution
Publication date: Available online 5 December 2017 Source:The Lancet Author(s): George D Thurston, Jonathan D Newman (Source: The Lancet)
Source: The Lancet - December 6, 2017 Category: General Medicine Source Type: research

Disease Control Priorities, 3rd edition —from theory to practice
Publication date: Available online 5 December 2017 Source:The Lancet Author(s): Pamela Das, Richard Horton (Source: The Lancet)
Source: The Lancet - December 6, 2017 Category: General Medicine Source Type: research

Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study
Publication date: Available online 5 December 2017 Source:The Lancet Author(s): Rudy Sinharay, Jicheng Gong, Benjamin Barratt, Pamela Ohman-Strickland, Sabine Ernst, Frank Kelly, Junfeng (Jim) Zhang, Peter Collins, Paul Cullinan, Kian Fan Chung Background Long-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic heart disease and exacerbations of COPD. We aimed to assess the...
Source: The Lancet - December 6, 2017 Category: General Medicine Source Type: research

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Publication date: Available online 5 December 2017 Source:The Lancet Author(s): Michael EJ Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Carl Peters, Sviatlana Zhyzhneuskaya, Ahmad Al-Mrabeh, Kieren G Hollingsworth, Angela M Rodrigues, Lucia Rehackova, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Hazel M Ross, Yvonne McIlvenna, Renae Stefanetti, Michael Trenell, Paul Welsh, Sharon Kean, Ian Ford, Alex McConnachie, Naveed Sattar, Roy Taylor Background Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management...
Source: The Lancet - December 6, 2017 Category: General Medicine Source Type: research

Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: phase 1, randomised, double-blind, placebo-controlled clinical trials
Publication date: Available online 5 December 2017 Source:The Lancet Author(s): Kayvon Modjarrad, Leyi Lin, Sarah L George, Kathryn E Stephenson, Kenneth H Eckels, Rafael A De La Barrera, Richard G Jarman, Erica Sondergaard, Janice Tennant, Jessica L Ansel, Kristin Mills, Michael Koren, Merlin L Robb, Jill Barrett, Jason Thompson, Alison E Kosel, Peter Dawson, Andrew Hale, C Sabrina Tan, Stephen R Walsh, Keith E Meyer, James Brien, Trevor A Crowell, Azra Blazevic, Karla Mosby, Rafael A Larocca, Peter Abbink, Michael Boyd, Christine A Bricault, Michael S Seaman, Anne Basil, Melissa Walsh, Veronica Tonwe, Daniel F Hoft, Ste...
Source: The Lancet - December 6, 2017 Category: General Medicine Source Type: research

Tradition and innovation in development of a Zika vaccine
Publication date: Available online 5 December 2017 Source:The Lancet Author(s): Ernesto T A Marques, Donald S Burke (Source: The Lancet)
Source: The Lancet - December 6, 2017 Category: General Medicine Source Type: research