Building a tuberculosis-free world: The Lancet Commission on tuberculosis
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Michael J A Reid, Nimalan Arinaminpathy, Amy Bloom, Barry R Bloom, Catharina Boehme, Richard Chaisson, Daniel P Chin, Gavin Churchyard, Helen Cox, Lucica Ditiu, Mark Dybul, Jeremy Farrar, Anthony S Fauci, Endalkachew Fekadu, Paula I Fujiwara, Timothy B Hallett, Christy L Hanson, Mark Harrington, Nick Herbert, Philip C Hopewell (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

India's leadership to end tuberculosis
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Jagat Prakash Nadda (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Time to bring tuberculosis out of the shadows
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Elizabeth Zuccala, Richard Horton (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Building a tuberculosis-free world on a foundation of universal health coverage
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Ban Ki-moon (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Tuberculosis
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Jennifer Furin, Helen Cox, Madhukar PaiSummaryTuberculosis remains the leading cause of death from an infectious disease among adults worldwide, with more than 10 million people becoming newly sick from tuberculosis each year. Advances in diagnosis, including the use of rapid molecular testing and whole-genome sequencing in both sputum and non-sputum samples, could change this situation. Although little has changed in the treatment of drug-susceptible tuberculosis, data on increased efficacy with new and repurposed drugs have led WHO to recommend ...
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Picturing health: it's time to act on tuberculosis
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Alexander Kumar (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Nandita Venkatesan: a voice of hope for tuberculosis survivors
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): John Zarocostas (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Inuit research raises concerns about tuberculosis eradication
Publication date: Available online 20 March 2019Source: The LancetAuthor(s): Paul Webster (Source: The Lancet)
Source: The Lancet - March 22, 2019 Category: General Medicine Source Type: research

Christine Sekaggya-Wiltshire: prizewinner in HIV–tuberculosis research
Publication date: Available online 19 March 2019Source: The LancetAuthor(s): Geoff Watts (Source: The Lancet)
Source: The Lancet - March 20, 2019 Category: General Medicine Source Type: research

Communication with children and adolescents about the diagnosis of their own life-threatening condition
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Alan Stein, Louise Dalton, Elizabeth Rapa, Myra Bluebond-Langner, Lucy Hanington, Kim Fredman Stein, Sue Ziebland, Tamsen Rochat, Emily Harrop, Brenda Kelly, Ruth Bland, Theresa Betancourt, Catherine D'Souza, Mina Fazel, Daniel Hochhauser, Barbara Kolucki, Aoife C Lowney, Elena Netsi, Linda Richter, Aisha YousafzaiSummaryWhen a child is diagnosed with a life-threatening condition, one of the most challenging tasks facing health-care professionals is how to communicate this to the child, and to their parents or caregivers. Evidence...
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

WHO reform continues to confuse
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Let's talk with children about life-threatening diseases
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Investment in health is key to boosting wealth
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Why accountability matters for universal health coverage and meeting the SDGs
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Alicia Ely Yamin, Elizabeth Mason, IAP (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Retraction—Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): The Lancet Editors (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

WHO structural overhaul draws mixed initial response
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): John Zarocostas (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Scott Gottlieb steps down from US FDA leadership
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Susan Jaffe (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

A sinister black finding in the stomach
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Wladyslaw Januszewicz, Pippa Corrie, Hongxiang Liu, James Chan, Rebecca C Fitzgerald, Massimiliano di Pietro (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Everything and the kitchen sink
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Michael Marmot (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Looking and seeing
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Roger Kneebone (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Child health and child rights: Uruguay's progeny
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Anne-Emanuelle Birn (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Margaret Denise Portman
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Geoff Watts (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Practical guidance for patient-centred health research
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Maarten de Wit, Cyrus Cooper, Jean-Yves Reginster, WHO-ESCEO Working Group (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Strengthening the legal framework to regulate human genetic engineering in China
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Cao Yanlin, Zheng Xueqian, Jia Fei (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

The need for a food-systems approach to policy making
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Riaz Bhunnoo (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

The KEYNOTE-061 trial
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Fei Liang (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

The KEYNOTE-061 trial – Authors' reply
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Kohei Shitara, Xinqun Chen (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Ebola virus disease and palliative care in humanitarian crises
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Favila Escobio, Elysée Nouvet (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Department of Error
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Communication with children and adolescents about the diagnosis of a life-threatening condition in their parent
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Louise Dalton, Elizabeth Rapa, Sue Ziebland, Tamsen Rochat, Brenda Kelly, Lucy Hanington, Ruth Bland, Aisha Yousafzai, Alan Stein, Theresa Betancourt, Myra Bluebond-Langner, Catherine D'Souza, Mina Fazel, Kim Fredman-Stein, Emily Harrop, Daniel Hochhauser, Barbara Kolucki, Aoife C Lowney, Elena Netsi, Linda RichterSummaryMany adults diagnosed with a life-threatening condition have children living at home; they and their partners face the dual challenge of coping with the diagnosis while trying to maintain a parenting role. Parents...
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

DR Congo Ebola virus treatment centres attacked
Publication date: 16–22 March 2019Source: The Lancet, Volume 393, Issue 10176Author(s): Andrew Green (Source: The Lancet)
Source: The Lancet - March 16, 2019 Category: General Medicine Source Type: research

Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Brian D Foy, Haoues Alout, Jonathan A Seaman, Sangeeta Rao, Tereza Magalhaes, Martina Wade, Sunil Parikh, Dieudonné D Soma, André B Sagna, Florence Fournet, Hannah C Slater, Roland Bougma, François Drabo, Abdoulaye Diabaté, A Gafar V Coulidiaty, Nöel Rouamba, Roch K DabiréSummaryBackgroundIvermectin is widely used in mass drug administrations for controlling neglected parasitic diseases, and can be lethal to malaria vectors that bite treated humans. Therefore, it could be a new tool to reduce plasmodium tran...
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Management of opioid use disorder in the USA: present status and future directions
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Carlos Blanco, Nora D VolkowSummaryOpioid use disorder is characterised by the persistent use of opioids despite the adverse consequences of its use. The disorder is associated with a range of mental and general medical comorbid disorders, and with increased mortality. Although genetics are important in opioid use disorder, younger age, male sex, and lower educational attainment level and income, increase the risk of opioid use disorder, as do certain psychiatric disorders (eg, other substance use disorders and mood disorders). The medications for...
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Prophylactic laser iridotomy in primary angle-closure suspects
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Robert N Weinreb, Sasan Moghimi (Source: The Lancet)
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Mingguang He, Yuzhen Jiang, Shengsong Huang, Dolly S Chang, Beatriz Munoz, Tin Aung, Paul J Foster, David S FriedmanSummaryBackgroundPrimary angle-closure glaucoma affects 20 million people worldwide. People classified as primary angle closure suspects have a higher but poorly quantified risk of developing glaucoma. We aimed to assess efficacy and safety of laser peripheral iridotomy prophylaxis against primary angle-closure glaucoma in Chinese people classified as primary angle closure suspects.MethodsIn this randomised controlled trial, bilatera...
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

The relationships between democratic experience, adult health, and cause-specific mortality in 170 countries between 1980 and 2016: an observational analysis
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Thomas J Bollyky, Tara Templin, Matthew Cohen, Diana Schoder, Joseph L Dieleman, Simon WigleySummaryBackgroundPrevious analyses of democracy and population health have focused on broad measures, such as life expectancy at birth and child and infant mortality, and have shown some contradictory results. We used a panel of data spanning 170 countries to assess the association between democracy and cause-specific mortality and explore the pathways connecting democratic rule to health gains.MethodsWe extracted cause-specific mortality and HIV-free life...
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Advancing the repurposing of ivermectin for malaria
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Carlos Chaccour, N Regina Rabinovich (Source: The Lancet)
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Optimising the continuum of child and adolescent health and development
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Zulfiqar A Bhutta, Cesar Victora, Ties Boerma, Margaret E Kruk, George Patton, Maureen M Black, Susan Sawyer, Susan Horton, Robert E Black, Richard Horton, Lancet Optimising Child Health Series Steering Committee (Source: The Lancet)
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Good news for democracy
Publication date: Available online 14 March 2019Source: The LancetAuthor(s): Helen Epstein (Source: The Lancet)
Source: The Lancet - March 14, 2019 Category: General Medicine Source Type: research

Improving adolescent health: an evidence-based call to action
Publication date: Available online 12 March 2019Source: The LancetAuthor(s): Helen A Weiss, Rashida A Ferrand (Source: The Lancet)
Source: The Lancet - March 13, 2019 Category: General Medicine Source Type: research

Shedding light on a million annual deaths in mid-childhood
Publication date: Available online 12 March 2019Source: The LancetAuthor(s): Li Liu, George Patton (Source: The Lancet)
Source: The Lancet - March 13, 2019 Category: General Medicine Source Type: research

Progress in adolescent health and wellbeing: tracking 12 headline indicators for 195 countries and territories, 1990–2016
Publication date: Available online 12 March 2019Source: The LancetAuthor(s): Peter S Azzopardi, Stephen J C Hearps, Kate L Francis, Elissa C Kennedy, Ali H Mokdad, Nicholas J Kassebaum, Stephen Lim, Caleb M S Irvine, Theo Vos, Alex D Brown, Surabhi Dogra, Stuart A Kinner, Natasha S Kaoma, Mariam Naguib, Nicola J Reavley, Jennifer Requejo, John S Santelli, Susan M Sawyer, Vegard Skirbekk, Marleen TemmermanSummaryBackgroundRapid demographic, epidemiological, and nutritional transitons have brought a pressing need to track progress in adolescent health. Here, we present country-level estimates of 12 headline indicators from t...
Source: The Lancet - March 13, 2019 Category: General Medicine Source Type: research

Trends in cause-specific mortality among children aged 5–14 years from 2005 to 2016 in India, China, Brazil, and Mexico: an analysis of nationally representative mortality studies
We present data on 12 main disease groups in all countries, with breakdown by communicable and nutritional diseases, non-communicable diseases, injuries, and ill-defined causes. To calculate age-specific and sex-specific death rates for each cause, we applied the national cause of death distribution to the UN mortality envelopes for 2005–16 for each country.FindingsUnlike Brazil, China, and Mexico, communicable diseases still account for nearly half of deaths in India in children aged 5–14 years (73 920 [46·1%] of 160 330 estimated deaths in 2016). In 2016, India had the highest death rates in nearly...
Source: The Lancet - March 13, 2019 Category: General Medicine Source Type: research

Venezuela's public health crisis: a regional emergency
Publication date: Available online 11 March 2019Source: The LancetAuthor(s): Kathleen R Page, Shannon Doocy, Feliciano Reyna Ganteaume, Julio S Castro, Paul Spiegel, Chris BeyrerSummaryThe economic crisis in Venezuela has eroded the country's health-care infrastructure and threatened the public health of its people. Shortages in medications, health supplies, interruptions of basic utilities at health-care facilities, and the emigration of health-care workers have led to a progressive decline in the operational capacity of health care. The effect of the crisis on public health has been difficult to quantify since the Venezu...
Source: The Lancet - March 13, 2019 Category: General Medicine Source Type: research

Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial
This study is registered at controlled-trials.com (ISRCTN32038223).FindingsOf 718 patients enrolled, 356 were randomised to the selective laser trabeculoplasty and 362 to the eye drops group. 652 (91%) returned the primary outcome questionnaire at 36 months. Average EQ-5D score was 0·89 (SD 0·18) in the selective laser trabeculoplasty group versus 0·90 (SD 0·16) in the eye drops group, with no significant difference (difference 0·01, 95% CI −0·01 to 0·03; p=0·23). At 36 months, 74·2% (95% CI 69·3–78·6) of patients in the selective lase...
Source: The Lancet - March 10, 2019 Category: General Medicine Source Type: research

Laser trabeculoplasty as first-line glaucoma treatment
Publication date: Available online 9 March 2019Source: The LancetAuthor(s): Jonathan W Young, Joesph Caprioli (Source: The Lancet)
Source: The Lancet - March 10, 2019 Category: General Medicine Source Type: research

Treatment of metabolic acidosis with an intestinal binder
Publication date: Available online 8 March 2019Source: The LancetAuthor(s): Shen Song, Glenn M Chertow (Source: The Lancet)
Source: The Lancet - March 9, 2019 Category: General Medicine Source Type: research

Post-Brexit food standards
Publication date: Available online 8 March 2019Source: The LancetAuthor(s): Tim Lang, Erik P Millstone (Source: The Lancet)
Source: The Lancet - March 9, 2019 Category: General Medicine Source Type: research

Veverimer versus placebo in patients with metabolic acidosis associated with chronic kidney disease: a multicentre, randomised, double-blind, controlled, phase 3 trial
Publication date: Available online 8 March 2019Source: The LancetAuthor(s): Donald E Wesson, Vandana Mathur, Navdeep Tangri, Yuri Stasiv, Dawn Parsell, Elizabeth Li, Gerrit Klaerner, David A BushinskySummaryBackgroundPatients with advanced chronic kidney disease lose the capacity to fully excrete endogenous acid, resulting in chronic metabolic acidosis that increases the risk of disease progression and causes muscle catabolism and bone resorption. Veverimer, a non-absorbed, counterion-free, polymeric drug, selectively binds and removes hydrochloric acid from the gastrointestinal lumen, unlike current oral sodium bicarbonat...
Source: The Lancet - March 9, 2019 Category: General Medicine Source Type: research