Harnessing the value of NHS patient data
Publication date: Available online 16 November 2018Source: The LancetAuthor(s): Jessamy Bagenal, Annemarie Naylor (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Looking beyond the Decade of Vaccines
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

The future of Trump's global health agenda
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Time to address nutritional security
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Where are the women in academic cardiology?
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Ersilia M DeFilippis, Emily S Lau, Janet Wei, Sharonne N Hayes, Malissa J Wood (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Offline: Part of the human experience
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Richard Horton (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Fighting a polio outbreak in Papua New Guinea
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Jo Chandler (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

So-called babies without arms cases cause concern in France
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Sharmila Devi (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Turkey's proposed bill could challenge doctors' livelihoods
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Sharmila Devi (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

In the front line
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Philip Ball (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

In search of motherhood
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Marco De Ambrogi (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Susan Buchbinder: driving HIV prevention efforts worldwide
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Tony Kirby (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

More haste, less speed: hyponatraemia and osmotic demyelination
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Purav Shah, Chelsea Jacobs, Ali Ataya (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Elizabeth Fee
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Ivan Oransky, Adam Marcus (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Risk thresholds for alcohol consumption
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Arne Astrup, Simona Costanzo, Giovanni de Gaetano (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Risk thresholds for alcohol consumption
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Eva Schernhammer (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Risk thresholds for alcohol consumption
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Warren Thompson (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Risk thresholds for alcohol consumption – Authors' reply
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Angela M Wood, Stephen Kaptoge, Ellie Paige, Emanuele Di Angelantonio, John Danesh (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Perspective of Middle Eastern war-displaced medical students
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Anas M Saad, Ahmad Kunbaz, Muneer J Al-Husseini (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Memory recall of traumatic events in refugees
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Philippe Charlier, Philippe Duverger, Fabiola Bou Abdallah (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Department of Error
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Reimagining addiction
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Sally Marlow (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

De-intensified treatment in human papillomavirus-positive oropharyngeal cancer
Publication date: Available online 15 November 2018Source: The LancetAuthor(s): Johannes Christiaan Oosthuizen, Jaime Doody (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial
This study is registered with ClinicalTrials.gov, number NCT01302834.FindingsBetween June 9, 2011, and July 31, 2014, 987 patients were enrolled, of whom 849 were randomly assigned to receive radiotherapy plus cetuximab (n=425) or radiotherapy plus cisplatin (n=424). 399 patients assigned to receive cetuximab and 406 patients assigned to receive cisplatin were subsequently eligible. After median follow-up duration of 4·5 years, radiotherapy plus cetuximab did not meet the non-inferiority criteria for overall survival (hazard ratio [HR] 1·45, one-sided 95% upper CI 1·94; p=0·5056 for non-inferior...
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial
Publication date: Available online 15 November 2018Source: The LancetAuthor(s): Hisham Mehanna, Max Robinson, Andrew Hartley, Anthony Kong, Bernadette Foran, Tessa Fulton-Lieuw, Matthew Dalby, Pankaj Mistry, Mehmet Sen, Lorcan O'Toole, Hoda Al Booz, Karen Dyker, Rafael Moleron, Stephen Whitaker, Sinead Brennan, Audrey Cook, Matthew Griffin, Eleanor Aynsley, Martin Rolles, Emma De WintonSummaryBackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatmen...
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

The health of Palestinians
Publication date: Available online 15 November 2018Source: The LancetAuthor(s): Rita Giacaman (Source: The Lancet)
Source: The Lancet - November 15, 2018 Category: General Medicine Source Type: research

Stopping medication for heart failure with improved ejection fraction
Publication date: Available online 11 November 2018Source: The LancetAuthor(s): Jane Wilcox, Clyde W Yancy (Source: The Lancet)
Source: The Lancet - November 12, 2018 Category: General Medicine Source Type: research

Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial
Publication date: Available online 11 November 2018Source: The LancetAuthor(s): Brian P Halliday, Rebecca Wassall, Amrit S Lota, Zohya Khalique, John Gregson, Simon Newsome, Robert Jackson, Tsveta Rahneva, Rick Wage, Gillian Smith, Lucia Venneri, Upasana Tayal, Dominique Auger, William Midwinter, Nicola Whiffin, Ronak Rajani, Jason N Dungu, Antonis Pantazis, Stuart A Cook, James S WareSummaryBackgroundPatients with dilated cardiomyopathy whose symptoms and cardiac function have recovered often ask whether their medications can be stopped. The safety of withdrawing treatment in this situation is unknown.MethodsWe did an ope...
Source: The Lancet - November 12, 2018 Category: General Medicine Source Type: research

Framing an agenda for children thriving in the SDG era: a WHO–UNICEF–Lancet Commission on Child Health and Wellbeing
Publication date: Available online 2 November 2018Source: The LancetAuthor(s): Awa Coll-Seck, Helen Clark, Rajiv Bahl, Stefan Peterson, Anthony Costello, Tamara Lucas (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials
Publication date: Available online 9 November 2018Source: The LancetAuthor(s): Pedro Cahn, Juan Sierra Madero, José Ramón Arribas, Andrea Antinori, Roberto Ortiz, Amanda E Clarke, Chien-Ching Hung, Jürgen K Rockstroh, Pierre-Marie Girard, Jörg Sievers, Choy Man, Alexander Currie, Mark Underwood, Allan R Tenorio, Keith Pappa, Brian Wynne, Anna Fettiplace, Martin Gartland, Michael Aboud, Kimberly SmithSummaryBackgroundEffective two-drug regimens could decrease long-term drug exposure and toxicity with HIV-1 antiretroviral therapy (ART). We therefore aimed to evaluate the efficacy and safety of a two-d...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

After Astana: building the economic case for increased investment in primary health care
Publication date: Available online 9 November 2018Source: The LancetAuthor(s): Hans Kluge, Ed Kelley, Soumya Swaminathan, Naoko Yamamoto, Senait Fisseha, Pavlos N Theodorakis, Søren Kristensen, Michael Anderson, Elias Mossialos (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Department of Error
Publication date: Available online 9 November 2018Source: The LancetAuthor(s): (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

A two-drug regimen for antiretroviral therapy
Publication date: Available online 9 November 2018Source: The LancetAuthor(s): Arne Kroidl, Joseph Eberle (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Isabel Emslie Hutton: a doctor at war
Publication date: Available online 10 November 2018Source: The LancetAuthor(s): Patricia Fara (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
Publication date: Available online 10 November 2018Source: The LancetAuthor(s): Thomas A Zelniker, Stephen D Wiviott, Itamar Raz, Kyungah Im, Erica L Goodrich, Marc P Bonaca, Ofri Mosenzon, Eri T Kato, Avivit Cahn, Remo H M Furtado, Deepak L Bhatt, Lawrence A Leiter, Darren K McGuire, John P H Wilding, Marc S SabatineSummaryBackgroundThe magnitude of effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on specific cardiovascular and renal outcomes and whether heterogeneity is based on key baseline characteristics remains undefined.MethodsWe did a systematic review and meta-analysis of randomised, placebo-controlled...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Pump, pipes, and filter: do SGLT2 inhibitors cover it all?
Publication date: Available online 10 November 2018Source: The LancetAuthor(s): Subodh Verma, Peter Jüni, C David Mazer (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

GBD 2017: a fragile world
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods.MethodsWe estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-s...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Gregory A Roth, Degu Abate, Kalkidan Hassen Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Haftom Temesgen Abebe, Molla Abebe, Zegeye Abebe, Ayenew Negesse Abejie, Semaw F Abera, Olifan Zewdie Abil, Haftom Niguse Abraha, Aklilu Roba AbrhamSummaryBackgroundGlobal development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Bur...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury.FundingBill & Melinda Gates Foundation. (Source: The Lancet)
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Hmwe Hmwe Kyu, Degu Abate, Kalkidan Hassen Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Molla Abebe, Zegeye Abebe, Olifan Zewdie Abil, Victor Aboyans, Aklilu Roba Abrham, Laith Jamal Abu-Raddad, Niveen M E Abu-Rmeileh, Manfred Mario Kokou AccrombessiSummaryBackgroundHow long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading ...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
This study included 476 risk–outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk expos...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Rafael Lozano, Nancy Fullman, Degu Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Omar Abdel-Rahman, Alireza Abdi, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Nebiyu Dereje Abebe, Zegeye Abebe, Ayenew Negesse Abejie, Semaw F Abera, Olifan Zewdie Abil, Victor AboyansSummaryBackgroundEfforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and thr...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Daniel Dicker, Grant Nguyen, Degu Abate, Kalkidan Hassen Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Omar Abdel-Rahman, Alireza Abdi, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Ahmed Abdulahi Abdurahman, Haftom Temesgen Abebe, Molla Abebe, Zegeye Abebe, Teshome Abuka AbeboSummaryBackgroundAssessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UN...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

WHO tracking mechanism for IHR additional health measures
Publication date: Available online 8 November 2018Source: The LancetAuthor(s): Adam Kamradt-Scott, Carmen Dolea, Corinne Poncé, Guénaël Rodier, Margaret Lamunu, Patrick Drury, Sophie Ioos (Source: The Lancet)
Source: The Lancet - November 9, 2018 Category: General Medicine Source Type: research

Safety of patient-facing digital symptom checkers
Publication date: Available online 6 November 2018Source: The LancetAuthor(s): Hamish Fraser, Enrico Coiera, David Wong (Source: The Lancet)
Source: The Lancet - November 7, 2018 Category: General Medicine Source Type: research

Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial
Publication date: Available online 5 November 2018Source: The LancetAuthor(s): Emil C Reisinger, Roland Tschismarov, Eckhard Beubler, Ursula Wiedermann, Christa Firbas, Micha Loebermann, Andrea Pfeiffer, Matthias Muellner, Erich Tauber, Katrin RamsauerSummaryBackgroundChikungunya fever is an emerging viral disease and substantial threat to public health. We aimed to assess the safety, tolerability, and immunogenicity of a live-attenuated, measles-vectored chikungunya vaccine (MV-CHIK).MethodsIn this double-blind, randomised, placebo-controlled and active-controlled phase 2 trial, we enrolled healthy volunteers aged 18&ndas...
Source: The Lancet - November 6, 2018 Category: General Medicine Source Type: research

Licensed chikungunya virus vaccine: a possibility?
Publication date: Available online 5 November 2018Source: The LancetAuthor(s): Ann M Powers (Source: The Lancet)
Source: The Lancet - November 6, 2018 Category: General Medicine Source Type: research