Renoprotection with indapamide, additional feature to look for
Publication date: Available online 31 January 2017 Source:Indian Heart Journal Author(s): Arindam Pande (Source: Indian Heart Journal)
Source: Indian Heart Journal - January 31, 2017 Category: Cardiology Source Type: research
[All diuretics used in the treatment of hypertension are not the same].
Abstract
Diuretics have been used for years to treat hypertension as both a monotherapy and in combination. Hydrochlorothiazide, indapamide, and chlorthalidone have frequently been considered in the same category as thiazide diuretics, but there is no evidence that their activities are similar. Studies have shown that chlorthalidone and indapamide reduce cardiovascular morbidity and mortality; however, there is no study indicating that hydrochlorothiazide has beneficial effects on cardiovascular outcomes such as myocardial infarction, renal failure, stroke, or death. Hydrochlorothiazide has less effect on ...
Source: Turk Kardiyoloji Dernegi arsivi - December 31, 2016 Category: Cardiology Authors: Asil S, Atalar E Tags: Turk Kardiyol Dern Ars Source Type: research
Full-dose Perindopril/Indapamide in the Treatment of Difficult-to-Control Hypertension: The FORTISSIMO Study
ConclusionsSwitching to PER/IND at full dose (10/2.5 mg) was well tolerated, leading to fast BP reduction and control in the majority of patients with uncontrolled hypertension, including difficult-to-treat patients with diabetes. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 21, 2016 Category: Drugs & Pharmacology Source Type: research
Relation between the TRIB3 Gln84Arg genetic variation and vascular complications in type 2 diabetes: an analysis of a 2 × 2 factorial randomised controlled trial
Publication date: November 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Supplement 1 Author(s): Fazhong He, Mouze Liu, Xingyu Wang, Xin Liu, Honghao Zhou, Xiaoping Chen, Wei Zhang Background The TRIB3 Gln84Arg polymorphism is associated with an increased risk of insulin resistance, coronary heart disease, and kidney disease in patients with type 2 diabetes. We aimed to explore the effect of this genetic variation on major vascular outcomes in patients with type 2 diabetes after blood pressure lowering and glycaemic control treatment. Methods We did an analysis of a 2 × 2 factorial rando...
Source: The Lancet Diabetes and Endocrinology - November 17, 2016 Category: Endocrinology Source Type: research
Diuretics in primary hypertension – Reloaded
Publication date: Available online 10 September 2016 Source:Indian Heart Journal Author(s): Sundeep Mishra Diuretics have long been cherished as drugs of choice for uncomplicated primary hypertension. Robust mortality and morbidity data is available for diuretics to back this strategy. Off-late the interest for diuretics has waned off perhaps due to availability of more effective drugs but more likely due to perceived lack of tolerance and side-effect profile of high-dose of diuretics required for mortality benefit. Low-dose diuretics particularly thiazide diuretics are safer but lack the mortality benefit shown by high...
Source: Indian Heart Journal - September 9, 2016 Category: Cardiology Source Type: research
Adherence to Antihypertensive Treatment and the Blood Pressure Lowering Effects of Renal Denervation in the Renal Denervation for Hypertension (DENERHTN) Trial.
CONCLUSIONS: -In the DENERHTN trial, the prevalence of non-adherence to antihypertensive drugs at 6 months was high (≈50%) but not different in the renal denervation and control groups. Regardless of adherence to treatment, renal denervation plus standardized stepped-care antihypertensive treatment resulted in a greater decrease in blood pressure than standardized stepped-care antihypertensive treatment alone. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01570777.
PMID: 27576780 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - August 29, 2016 Category: Cardiology Authors: Azizi M, Pereira H, Hamdidouche I, Gosse P, Monge M, Bobrie G, Delsart P, Mounier-Véhier C, Courand PY, Lantelme P, Denolle T, Dourmap-Collas C, Girerd X, Halimi JM, Zannad F, Ormezzano O, Vaisse B, Herpin D, Ribstein J, Chamontin B, Mourad JJ, Ferrari E Tags: Circulation Source Type: research
Antihypertensive treatment decreases arterial stiffness at night but not during the day. Results from the Hypertension in the Very Elderly Trial.
This report from the ambulatory blood pressure sub-study investigates whether changes in arterial stiffness and ambulatory blood pressure (BP) could both explain the benefits observed in the main trial. A total of 139 participants were randomized to placebo [67] and to active treatment [72] and had both day and night observations of BP and arterial stiffness as determined from the Q wave Korotkoff diastolic (QKD) interval. The QKD interval was 5.6 ms longer (p = 0.017) in the actively treated group at night than in the placebo group. This was not true for the more numerous daytime readings so that 24-h results were s...
Source: Blood Pressure - August 24, 2016 Category: Hematology Tags: Blood Press Source Type: research
The Results of ACES (Antihypertensive Combinations ’ Long Term Efficacy Comparing Study): Analysis of Metabolic Effects of Antihypertensive Combination Therapies
Conclusions < /h3 > < p class= " a-plus-plus " > Based on our findings, we conclude that the metabolic profile of indapamide is very similar to the metabolically neutral and well-documented metabolic profiles of the calcium-channel blocker amlodipine and the vasodilator β-blocker carvedilol and that all the combinations studied had similar beneficial effects on the main metabolic parameters. The favorable changes of metabolic parameters are because of the discontinuation of active substances (e.g., conventional thiazides, second-generation β-blockers) used in the previous therapy, which were associated with unfavorable ...
Source: Clinical Drug Investigation - July 11, 2016 Category: Drugs & Pharmacology Source Type: research
The Results of ACES (Antihypertensive Combinations’ Long Term Efficacy Comparing Study): Analysis of Metabolic Effects of Antihypertensive Combination Therapies
Conclusions
Based on our findings, we conclude that the metabolic profile of indapamide is very similar to the metabolically neutral and well-documented metabolic profiles of the calcium-channel blocker amlodipine and the vasodilator β-blocker carvedilol and that all the combinations studied had similar beneficial effects on the main metabolic parameters. The favorable changes of metabolic parameters are because of the discontinuation of active substances (e.g., conventional thiazides, second-generation β-blockers) used in the previous therapy, which were associated with unfavorable metabolic effects,...
Source: Clinical Drug Investigation - July 11, 2016 Category: Drugs & Pharmacology Source Type: research
Effect of different drug classes on reverse remodeling of intramural coronary arterioles in the spontaneously hypertensive rat
ConclusionsThe effect of anti‐hypertensive treatment on CMD is not only dependent on BP reduction. Compounds with comparable anti‐hypertensive efficacy may exert different effects on CF and induce different degrees of reverse arteriolar remodeling.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - June 30, 2016 Category: Research Authors: Massimiliano Mancini, Angela Scavone, Carmem Luiza Sartorio, Rocco Baccaro, Christina Kleinert, Angelina Pernazza, Veronica Buia, Martina Leopizzi, Giulia D'amati, Paolo G. Camici Tags: Original Research Source Type: research
Clinical pharmacology questions
An 81-year-old man attended the hypertension clinic for review. He also had atrial fibrillation and chronic renal impairment. He was already taking aspirin, digoxin, indapamide and ramipril. (Source: Medicine)
Source: Medicine - June 3, 2016 Category: Internal Medicine Tags: Self-assessment/CPD Source Type: research
Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design.
Abstract
To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. Because of the low active pharmaceutical ingredient content, it was hypothesized that both powder and tablet properties could be determined only by the characteristics of excipients. In order to test this assumption, both experimental designs were done with placebo mixtures. The optimized formulation was then evaluated both with and wit...
Source: Acta Pharmaceutica - May 31, 2016 Category: Drugs & Pharmacology Authors: Szabó ZI, Székely-Szentmiklósi B, Deák B, Székely-Szentmiklósi I, Kovács B, Zöldi K, Sipos E Tags: Acta Pharm Source Type: research
Effects of antihypertensive treatment on plasma apelin, resistin, and visfatin concentrations.
CONCLUSIONS Antihypertensive treatment exerts significant and varied effects on adipokine secretion in obese hypertensive patients. Changes in apelin secretion, caused by the use of different antihypertensive drugs, may protect the cardiovascular system and kidneys. The involvement of adipokins in the mechanism of diverse protective effects of antihypertensive drugs, independently of the effect on blood pressure, requires further research.
PMID: 27129086 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)
Source: Polskie Archiwum Medycyny Wewnetrznej - April 30, 2016 Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research
Addition of indapamide to frusemide increases natriuresis and creatinine clearance, but not diuresis, in fluid overloaded ICU patients
Conclusion In fluid overloaded ICU patients, addition of indapamide to frusemide led to a greater natriuresis and creatinine clearance. Such a strategy might be utilised in optimising sodium balance in ICU patients. (Source: Journal of Critical Care)
Source: Journal of Critical Care - April 19, 2016 Category: Gastroenterology Source Type: research
Diuretics for Hypertension: A Review and Update.
Abstract
This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypertensive medication, and thiazide-related diuretics have increased at a rate greater than that of antihypertensive medications as a whole. The latest hypertension guidelines have underscored the importance of diuretics for all patients, but particularly for those with salt-sensitive and...
Source: American Journal of Hypertension - April 4, 2016 Category: Cardiology Authors: Roush GC, Sica DA Tags: Am J Hypertens Source Type: research
