Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis.
Abstract Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta-analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol. Twelve trials were identified: five...
Source: J Cell Mol Med - June 19, 2017 Category: Molecular Biology Authors: Liang W, Ma H, Cao L, Yan W, Yang J Tags: J Cell Mol Med Source Type: research

Blood pressure-lowering efficacy and safety of perindopril/indapamide/amlodipine single-pill combination in patients with uncontrolled essential hypertension: a multicenter, randomized, double-blind, controlled trial
Objectives: This 4-month, double-blind, randomized, controlled trial was designed to demonstrate the superiority of perindopril/indapamide/amlodipine single pill over perindopril/indapamide after 1 month and to determine further up-titration efficacy and safety in patients with mild-to-moderate hypertension. Methods: After a 1-month run-in period on perindopril/indapamide 5/1.25 mg, patients with SBP/DBP at least 150/95 mmHg and no diabetes or renal insufficiency received perindopril/indapamide/amlodipine 5/1.25/5 mg single pill or continued on the same treatment. At 1, 2, and 3 months, patients with uncontrolled bl...
Source: Journal of Hypertension - June 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs.
In conclusion, renal denervation decreases blood pressure in hypertensive rats. The hypotensive action of metoprolol, indapamide, and losartan is not augmented by renal denervation, suggesting the absence of synergy between renal denervation and the drugs investigated in this study. PMID: 28448180 [PubMed - in process] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 29, 2017 Category: Cardiology Authors: Skrzypecki J, Gawlak M, Huc T, Szulczyk P, Ufnal M Tags: Clin Exp Hypertens Source Type: research

Fixed-Dose Triple Combination of Antihypertensive Drugs Improves Blood Pressure Control: From Clinical Trials to Clinical Practice
This study compared the efficacy of a fixed-dose triple combination (FDTC) of antihypertensive drugs with that of a free combination of three antihypertensives in patients with uncontrolled hypertension.MethodsNinety-two patients (mean age 60.8 ± 12.1, 58.0% male) with uncontrolled essential hypertension (office systolic BP ≥ 140 or diastolic BP ≥ 90 mmHg) previously treated with a renin–angiotensin–aldosterone system (RAAS) inhibitor plus hydrochlorothiazide were switched to once-daily FDTC therapy with perindopril/indapamid e/amlodipine (5–10/1.25–2.5/5–...
Source: Advances in Therapy - March 15, 2017 Category: Drugs & Pharmacology Source Type: research

Single-Pill Combination of Perindopril/Indapamide/Amlodipine in Patients with Uncontrolled Hypertension: A Randomized Controlled Trial
AbstractIntroductionPatients with hypertension often require a combination of three antihypertensive agents to achieve  blood pressure control, but very few single-pill triple combinations are available. The aim of this study was to determine whether a single-pill triple combination of perindopril, indapamide, and amlodipine was as effective as a dual-pill combination of perindopril/indapamide plus separate amlodi pine at reducing blood pressure in patients with uncontrolled, essential hypertension.MethodsThis international, multicenter, open-label, randomized controlled trial was conducted in men or women aged &...
Source: Cardiology and Therapy - February 8, 2017 Category: Cardiology Source Type: research

High-throughput NIR-chemometric methods for chemical and pharmaceutical characterization of sustained release tablets
Publication date: 10 May 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 138 Author(s): Alina Porfire, Cristina Filip, Ioan Tomuta The aim of this study was the development and validation of methods based on near-infrared spectroscopy (NIRS) and chemometry, useful for characterization of sustained release (SR) tablets with indapamide, in terms of tablet composition (API and two excipients), in vitro drug release mechanism (k and n Peppas) and crushing strength. A calibration set consisting of 25 different tablets formulations containing API, HPMC and lactose at five different content levels in the ra...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 5, 2017 Category: Drugs & Pharmacology Source Type: research

Renoprotection with indapamide, additional feature to look for
Publication date: Available online 31 January 2017 Source:Indian Heart Journal Author(s): Arindam Pande (Source: Indian Heart Journal)
Source: Indian Heart Journal - February 1, 2017 Category: Cardiology Source Type: research

[All diuretics used in the treatment of hypertension are not the same].
Abstract Diuretics have been used for years to treat hypertension as both a monotherapy and in combination. Hydrochlorothiazide, indapamide, and chlorthalidone have frequently been considered in the same category as thiazide diuretics, but there is no evidence that their activities are similar. Studies have shown that chlorthalidone and indapamide reduce cardiovascular morbidity and mortality; however, there is no study indicating that hydrochlorothiazide has beneficial effects on cardiovascular outcomes such as myocardial infarction, renal failure, stroke, or death. Hydrochlorothiazide has less effect on blood pr...
Source: Turk Kardiyoloji Dernegi arsivi - January 1, 2017 Category: Cardiology Authors: Asil S, Atalar E Tags: Turk Kardiyol Dern Ars Source Type: research

Full-dose Perindopril/Indapamide in the Treatment of Difficult-to-Control Hypertension: The FORTISSIMO Study
AbstractBackground and ObjectiveBlood pressure (BP) control in hypertensive patients remains poor worldwide, particularly in high-risk patients with hypertension and diabetes. Guidelines recommend that such patients receive prompt pharmacological therapy at maximal doses to rapidly control BP. We aimed to evaluate efficacy and safety of single-pill combination (SPC) perindopril/indapamide (PER/IND) at full dose (10/2.5  mg) in hypertensive patients, including diabetics, with BP uncontrolled by previous medication.MethodsTwelve-week prospective, observational study in patients with uncontrolled hypertension ( ≥160&n...
Source: Clinical Drug Investigation - November 22, 2016 Category: Drugs & Pharmacology Source Type: research

Relation between the TRIB3 Gln84Arg genetic variation and vascular complications in type 2 diabetes: an analysis of a 2  × 2 factorial randomised controlled trial
Publication date: November 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Supplement 1 Author(s): Fazhong He, Mouze Liu, Xingyu Wang, Xin Liu, Honghao Zhou, Xiaoping Chen, Wei Zhang Background The TRIB3 Gln84Arg polymorphism is associated with an increased risk of insulin resistance, coronary heart disease, and kidney disease in patients with type 2 diabetes. We aimed to explore the effect of this genetic variation on major vascular outcomes in patients with type 2 diabetes after blood pressure lowering and glycaemic control treatment. Methods We did an analysis of a 2 × 2 factorial randomise...
Source: The Lancet Diabetes and Endocrinology - November 18, 2016 Category: Endocrinology Source Type: research

Diuretics in primary hypertension – Reloaded
Publication date: Available online 10 September 2016 Source:Indian Heart Journal Author(s): Sundeep Mishra Diuretics have long been cherished as drugs of choice for uncomplicated primary hypertension. Robust mortality and morbidity data is available for diuretics to back this strategy. Off-late the interest for diuretics has waned off perhaps due to availability of more effective drugs but more likely due to perceived lack of tolerance and side-effect profile of high-dose of diuretics required for mortality benefit. Low-dose diuretics particularly thiazide diuretics are safer but lack the mortality benefit shown by high-d...
Source: Indian Heart Journal - September 10, 2016 Category: Cardiology Source Type: research

Adherence to Antihypertensive Treatment and the Blood Pressure Lowering Effects of Renal Denervation in the Renal Denervation for Hypertension (DENERHTN) Trial.
CONCLUSIONS: -In the DENERHTN trial, the prevalence of non-adherence to antihypertensive drugs at 6 months was high (≈50%) but not different in the renal denervation and control groups. Regardless of adherence to treatment, renal denervation plus standardized stepped-care antihypertensive treatment resulted in a greater decrease in blood pressure than standardized stepped-care antihypertensive treatment alone. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01570777. PMID: 27576780 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - August 30, 2016 Category: Cardiology Authors: Azizi M, Pereira H, Hamdidouche I, Gosse P, Monge M, Bobrie G, Delsart P, Mounier-Véhier C, Courand PY, Lantelme P, Denolle T, Dourmap-Collas C, Girerd X, Halimi JM, Zannad F, Ormezzano O, Vaisse B, Herpin D, Ribstein J, Chamontin B, Mourad JJ, Ferrari E Tags: Circulation Source Type: research

Antihypertensive treatment decreases arterial stiffness at night but not during the day. Results from the Hypertension in the Very Elderly Trial.
This report from the ambulatory blood pressure sub-study investigates whether changes in arterial stiffness and ambulatory blood pressure (BP) could both explain the benefits observed in the main trial. A total of 139 participants were randomized to placebo [67] and to active treatment [72] and had both day and night observations of BP and arterial stiffness as determined from the Q wave Korotkoff diastolic (QKD) interval. The QKD interval was 5.6 ms longer (p = 0.017) in the actively treated group at night than in the placebo group. This was not true for the more numerous daytime readings so that 24-h...
Source: Blood Pressure - August 24, 2016 Category: Hematology Tags: Blood Press Source Type: research

The Results of ACES (Antihypertensive Combinations’ Long Term Efficacy Comparing Study): Analysis of Metabolic Effects of Antihypertensive Combination Therapies
Conclusions Based on our findings, we conclude that the metabolic profile of indapamide is very similar to the metabolically neutral and well-documented metabolic profiles of the calcium-channel blocker amlodipine and the vasodilator β-blocker carvedilol and that all the combinations studied had similar beneficial effects on the main metabolic parameters. The favorable changes of metabolic parameters are because of the discontinuation of active substances (e.g., conventional thiazides, second-generation β-blockers) used in the previous therapy, which were associated with unfavorable metabolic effects, a...
Source: Clinical Drug Investigation - July 12, 2016 Category: Drugs & Pharmacology Source Type: research

The Results of ACES (Antihypertensive Combinations ’ Long Term Efficacy Comparing Study): Analysis of Metabolic Effects of Antihypertensive Combination Therapies
Conclusions Based on our findings, we conclude that the metabolic profile of indapamide is very similar to the metabolically neutral and well-documented metabolic profiles of the calcium-channel blocker amlodipine and the vasodilator β-blocker carvedilol and that all the combinations studied had similar beneficial effects on the main metabolic parameters. The favorable changes of metabolic parameters are because of the discontinuation of active substances (e.g., conventional thiazides, second-generation β-blockers) used in the previous therapy, which were associated with unfavorable metabolic effects, and to the...
Source: Clinical Drug Investigation - July 12, 2016 Category: Drugs & Pharmacology Source Type: research

Effect of different drug classes on reverse remodeling of intramural coronary arterioles in the spontaneously hypertensive rat
ConclusionsThe effect of anti‐hypertensive treatment on CMD is not only dependent on BP reduction. Compounds with comparable anti‐hypertensive efficacy may exert different effects on CF and induce different degrees of reverse arteriolar remodeling.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - July 1, 2016 Category: Research Authors: Massimiliano Mancini, Angela Scavone, Carmem Luiza Sartorio, Rocco Baccaro, Christina Kleinert, Angelina Pernazza, Veronica Buia, Martina Leopizzi, Giulia D'amati, Paolo G. Camici Tags: Original Research Source Type: research

Clinical pharmacology questions
An 81-year-old man attended the hypertension clinic for review. He also had atrial fibrillation and chronic renal impairment. He was already taking aspirin, digoxin, indapamide and ramipril. (Source: Medicine)
Source: Medicine - June 4, 2016 Category: Internal Medicine Tags: Self-assessment/CPD Source Type: research

Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental design.
;si I, Kovács B, Zöldi K, Sipos E Abstract To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. Because of the low active pharmaceutical ingredient content, it was hypothesized that both powder and tablet properties could be determined only by the characteristics of excipients. In order to test this assumption, both experimental designs were done with placebo mixtures. The optimized formulatio...
Source: Acta Pharmaceutica - June 1, 2016 Category: Drugs & Pharmacology Authors: Szabó ZI, Székely-Szentmiklósi B, Deák B, Székely-Szentmiklósi I, Kovács B, Zöldi K, Sipos E Tags: Acta Pharm Source Type: research

Effects of antihypertensive treatment on plasma apelin, resistin, and visfatin concentrations.
CONCLUSIONS Antihypertensive treatment exerts significant and varied effects on adipokine secretion in obese hypertensive patients. Changes in apelin secretion, caused by the use of different antihypertensive drugs, may protect the cardiovascular system and kidneys. The involvement of adipokins in the mechanism of diverse protective effects of antihypertensive drugs, independently of the effect on blood pressure, requires further research. PMID: 27129086 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)
Source: Polskie Archiwum Medycyny Wewnetrznej - April 30, 2016 Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research

Addition of indapamide to frusemide increases natriuresis and creatinine clearance, but not diuresis, in fluid overloaded ICU patients
Conclusion In fluid overloaded ICU patients, addition of indapamide to frusemide led to a greater natriuresis and creatinine clearance. Such a strategy might be utilised in optimising sodium balance in ICU patients. (Source: Journal of Critical Care)
Source: Journal of Critical Care - April 20, 2016 Category: Gastroenterology Source Type: research

Diuretics for Hypertension: A Review and Update.
Abstract This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypertensive medication, and thiazide-related diuretics have increased at a rate greater than that of antihypertensive medications as a whole. The latest hypertension guidelines have underscored the importance of diuretics for all patients, but particularly for those with salt-sensitive and resista...
Source: American Journal of Hypertension - April 5, 2016 Category: Cardiology Authors: Roush GC, Sica DA Tags: Am J Hypertens Source Type: research

Validated liquid chromatography–tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma
Publication date: 5 June 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 125 Author(s): Mohie M.K. Sharaf El-Din, Mohamed W.I. Nassar, Khalid A.M. Attia, Maha A.El Demellawy, Mohamed M.Y. Kaddah A simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method was developed and validated for the simultaneous quantitation of clopamide, reserpine and dihydroergotoxine (ergoloid mesylates) in human plasma. Under basic conditions, liquid–liquid extraction using ethyl acetate was efficiently used for extraction of the analytes from pl...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 31, 2016 Category: Drugs & Pharmacology Source Type: research

Quantifying intermolecular interactions in solid state indapamide and other popular diuretic drugs: Insights from Hirshfeld surface study
Publication date: 15 July 2016 Source:Journal of Molecular Structure, Volume 1116 Author(s): Joanna Bojarska, Andrzej Fruziński, Waldemar Maniukiewicz Hirshfeld surfaces (HS) and two-dimensional fingerprint plots are used to analyze the intermolecular interactions in indapamide and other popular thiazide diuretic derivatives. The crystal structure of indapamide (INDP) at 100 K determined by single-crystal X-ray analysis, is also reported. The title compound crystallizes in the centrosymmetric I2/a space group with one indapamide and half water molecule (lying on the glide plane) in the asymmetric unit. An interp...
Source: Journal of Molecular Structure - March 15, 2016 Category: Molecular Biology Source Type: research

Evaluation of drug-carrier interactions in quaternary powder mixtures containing perindopril tert-butylamine and indapamide
Publication date: 30 April 2016 Source:International Journal of Pharmaceutics, Volume 503, Issues 1–2 Author(s): Adam Voelkel, Kasylda Milczewska, Michał Teżyk, Bartłomiej Milanowski, Janina Lulek Interactions occurring between components in the quaternary powder mixtures consisting of perindopril tert-butylamine, indapamide (active pharmaceutical ingredients), carrier substance and hydrophobic colloidal silica were examined. Two grades of lactose monohydrate: Spherolac® 100 and Granulac® 200 and two types of microcrystalline cellulose: M101D+ and Vivapur® 102 were used as carriers. We determine...
Source: International Journal of Pharmaceutics - March 5, 2016 Category: Drugs & Pharmacology Source Type: research

Risks associated with permanent discontinuation of blood pressure-lowering medications in patients with type 2 diabetes
Conclusion: Discontinuation of study medication is a potent risk marker for identifying high-risk patients. Thus it is important that clinicians seek to identify such patients early after discontinuation of treatment. Although some short-term residual effects of previous active treatment can be expected, patients who discontinue require further urgent investigation and management. (Source: Journal of Hypertension)
Source: Journal of Hypertension - March 4, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Simultaneous high-throughput determination of interaction kinetics for drugs and cyclodextrins by high performance affinity chromatography with mass spectrometry detection.
In this study, a HPAC with mass spectrometry detection (HPAC-MS/MS) was employed to determine the drug-cyclodextrin (CD) interaction kinetics with low sample loading quantity (
Source: Analytica Chimica Acta - February 8, 2016 Category: Chemistry Authors: Wang C, Wang X, Xu X, Liu B, Xu X, Sun L, Li H, Zhang J Tags: Anal Chim Acta Source Type: research

13C solid-state NMR analysis of the most common pharmaceutical excipients used in solid drug formulations Part II: CP kinetics and relaxation analysis
Publication date: 15 April 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 122 Author(s): Dariusz Maciej Pisklak, Monika Zielińska-Pisklak, Łukasz Szeleszczuk, Iwona Wawer Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters. Therefore, experimental parameters like contact time of cross-polarization and repetition time have a major impact on the registered solid state NMR spectra and in consequence on the results of the NMR analysis. In this work the CP kinetics and relaxation of the most common pharmaceutical excipie...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 3, 2016 Category: Drugs & Pharmacology Source Type: research

Addition of indapamide to frusemide increases natriuresis and creatinine clearance, but not diuresis, in fluid overloaded ICU patients
The objective of this study was to examine the effect of adding indapamide to frusemide on diuresis, natriuresis, creatinine clearance and serum electrolytes. (Source: Journal of Critical Care)
Source: Journal of Critical Care - January 27, 2016 Category: Intensive Care Authors: Shailesh Bihari, Andrew W. Holt, Shivesh Prakash, Andrew D. Bersten Source Type: research

Correction of endothelial dysfunction in patients with COPD and concomitant arterial hypertension
Endothelial dysfunction is a common pathogenetic mechanism of COPD and hypertension. Identification of additional pleiotropic effects of antihypertensive drugs is very actual.Aims: To identify opportunities for correction of endothelial dysfunction in patients with COPD and concomitant hypertension with slow-release (SR) formulation of indapamide.Methods: 42 out-patients with COPD and concomitant hypertension were recruited (34 male, mean age of 66.5±8.4, %FEV1 58.4±11.5%, index smoker 44.6±20.1). COPD duration was 5.8±4.5 years, hypertension duration was 11.3±8.9 years. All patients were...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Nersesyan, Z., Ovcharenko, S., Morozova, T. Tags: 1.12 Clinical Problems - COPD Source Type: research

Red cell distribution width in type 2 diabetic patients
Conclusion: RDW, which is recently considered as an inflammatory marker with a significant predictive value of mortality in diseased and healthy populations, is significantly higher in diabetic patients than healthy subjects and is particularly higher in uncontrolled glycemia. None of the studied hypoglycemic agents showed a significant effect on RDW. Diabetic hypertensive patients receiving antihypertensive therapy in the form of indapamide or the combined therapy of thiazides and angiotensin receptor blockers have RDW values comparable to those of the healthy population. Keywords: red cell distribution, platelet, diabete...
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - October 29, 2015 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Antihypertensive therapy increases natural immunity response in hypertensive patients
Publication date: Available online 26 October 2015 Source:Life Sciences Author(s): Henrique Andrade R. Fonseca, Francisco A. Fonseca, Lívia C. Lins, Andrea M. Monteiro, Henrique T. Bianco, Sergio A. Brandão, Rui M. Povoa, Luiz Juliano, Antônio M. Figueiredo-Neto, Paulo Boschcov, Magnus Gidlund, Maria C. Izar Aims The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function. Main methods Eighty-eight patients with hypertension (stage 1 o...
Source: Life Sciences - October 26, 2015 Category: Biology Source Type: research

Budget Impact Analysis Of Tripliam For The Treatment Of Hypertension In Italy
The objective of this study was to perform a Budget Impact Analysis (BIA) assessing the introduction of Tripliam for the treatment of hypertension into the Italian market. Tripliam is the first and only available single-tablet triple combination antihypertensive therapy containing perindopril, amlodipine and indapamide, in line with current evidence-based recommendations for the treatment and management of hypertension. (Source: Value in Health)
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: EP Lanati, VL Orlando Source Type: research

Molecular Dynamics and Physical Stability of Coamorphous Ezetimib and Indapamide Mixtures
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.5b00334 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - September 1, 2015 Category: Drugs & Pharmacology Authors: J. Knapik, Z. Wojnarowska, K. Grzybowska, K. Jurkiewicz, L. Tajber and M. Paluch Source Type: research

Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches.
Abstract A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in three fixed-dose formulations. The dissolution procedure was optimized using different media, different pH of the buffer, surfactants, paddle speed and temperature. Similarity of dissolution profiles was estimated using different model-independent and model-dependent methods and, additionally, by principal com...
Source: Acta Pharmaceutica - September 1, 2015 Category: Drugs & Pharmacology Authors: Gumieniczek A, Mączka P, Komsta Ł, Pietraś R Tags: Acta Pharm Source Type: research

Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic
Purpose of review: To determine usefulness and versatility of hydrochlorothiazide (HCTZ) relative to other thiazide diuretics in the treatment of hypertension. Recent findings: HCTZ was found to be less potent in lowering blood pressure (BP) than other thiazide diuretics, including chlorthalidone (CTD) and bendroflumethiazide. A recent meta-analysis also suggested HCTZ (12.5–25 mg daily) to be less potent than antihypertensive agents from several other classes, including angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and calcium antagonists. The risk of hyponatremia, hypokalemia, and hyper...
Source: Current Opinion in Cardiology - June 8, 2015 Category: Cardiology Tags: HYPERTENSION: Edited by Franz H. Messerli and Stefano F. Rimoldi Source Type: research

Effects of a selective aldosterone blocker and thiazide-type diuretic on blood pressure and organ damage in hypertensive patients.
In conclusion, eplerenone and indapamide were similarly effective in lowering office and home BPs in hypertensive patients treated with CCBs and ARBs. Eplerenone may exert more favorable effects on arterial stiffness and oxidative stress. PMID: 25992488 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 20, 2015 Category: Cardiology Authors: Ohta Y, Ishizuka A, Hayashi S, Iwashima Y, Kishida M, Yoshihara F, Nakamura S, Kawano Y Tags: Clin Exp Hypertens Source Type: research

Economic evaluation of single-pill combination of indapamide and amlodipine in the treatment of arterial hypertension in the Polish setting.
CONCLUSIONS: The treatment with SPC of indapamide and amlodipine for hypertensive patients was found to be dominant over FC or at least less expensive then treatment with FC when the difference in effectiveness was neglected. The replacement of FC with SPC shall result in savings from both NHF perspective and NHF and patient's perspective. PMID: 25987296 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - May 19, 2015 Category: Cardiology Authors: Kawalec P, Holko P, Stawowczyk E, Borowiec Ł, Filipiak KJ Tags: Kardiol Pol Source Type: research

Volume Overload and Adverse Outcomes in Chronic Kidney Disease: Clinical Observational and Animal Studies [Kidney in Cardiovascular Disease]
Conclusions Volume overload contributes to CKD progression and cardiovascular diseases. Further research is warranted to clarify whether the correction of volume overload would improve outcomes for CKD patients. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 5, 2015 Category: Cardiology Authors: Hung, S.-C., Lai, Y.-S., Kuo, K.-L., Tarng, D.-C. Tags: Kidney in Cardiovascular Disease Source Type: research

Indapamide: Is It The Better Diuretic for Hypertension? [Editorial Commentaries]
(Source: Hypertension)
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Kaplan, N. M. Tags: Cardiovascular Pharmacology, Other hypertension, Clinical Studies Editorial Commentaries Source Type: research

Head-to-Head Comparisons of Hydrochlorothiazide With Indapamide and Chlorthalidone: Antihypertensive and Metabolic Effects [Meta-Analysis: Diuretics]
In conclusion, these head-to-head comparisons demonstrate that, like chlorthalidone, INDAP is more potent than HCTZ at commonly prescribed doses without evidence for greater adverse metabolic effects. (Source: Hypertension)
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Roush, G. C., Ernst, M. E., Kostis, J. B., Tandon, S., Sica, D. A. Tags: Clinical Studies, Other Treatment Meta-Analysis: Diuretics Source Type: research

Not Just Chlorthalidone: Evidence-Based, Single Tablet, Diuretic Alternatives to Hydrochlorothiazide for Hypertension
Abstract Accounting for 15 % of deaths worldwide, hypertension is often treated with hydrochlorothiazide (HCTZ) (50 million prescriptions annually). HCTZ has a
Source: Current Hypertension Reports - March 28, 2015 Category: Primary Care Source Type: research

Prevention of metabolic disorders with telmisartan and indapamide in a Chinese population with high-normal blood pressure
g Lu & Wei Zhang (Source: Hypertension Research)
Source: Hypertension Research - February 5, 2015 Category: Cardiology Authors: Jie PengYingxin ZhaoHua ZhangZhendong LiuZhihao WangMengxiong TangMing ZhongFanghong LuWei Zhang Tags: abdominal obesity high-normal blood pressure metabolic syndrome pharmacoeconomics Source Type: research

Dual-directional regulation of drug permeating amount by combining the technique of ion-pair complexation with chemical enhancers for the synchronous permeation of indapamide and bisoprolol in their compound patch through rabbit skin.
Abstract To achieve the synchronous skin permeation of indapamide (IND) and bisoprolol (BSP) in their compound patch, the technique of ion-pair complexation and chemical enhancers was combined to dual-directionally regulate drug permeating amounts. Ion-pair complexes of BSP and various organic acids were formed by the technique of ion-pair complexation. Among the complexes formed, bisoprolol tartrate (BSP.T) down-regulated the permeating amount of BSP to the same extent as that of IND. Then, to simultaneously up-regulate the amounts of the two drugs, an enhancer combination of 15.8% Span80 (SP), 6.0% Azone (AZ) an...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 4, 2015 Category: Drugs & Pharmacology Authors: Song W, Cun D, Quan P, Liu N, Chen Y, Cui H, Xiang R, Fang L Tags: Eur J Pharm Biopharm Source Type: research

Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial
Publication date: Available online 26 January 2015 Source:The Lancet Author(s): Michel Azizi , Marc Sapoval , Philippe Gosse , Matthieu Monge , Guillaume Bobrie , Pascal Delsart , Marco Midulla , Claire Mounier-Véhier , Pierre-Yves Courand , Pierre Lantelme , Thierry Denolle , Caroline Dourmap-Collas , Hervé Trillaud , Helena Pereira , Pierre-François Plouin , Gilles Chatellier Background Conflicting blood pressure-lowering effects of catheter-based renal artery denervation have been reported in patients with resistant hypertension. We compared the ambulatory blood pressure-lowering efficacy and safe...
Source: The Lancet - January 27, 2015 Category: Journals (General) Source Type: research

Comparison of single-pill strategies first line in hypertension: perindopril/amlodipine versus valsartan/amlodipine
Objectives: An international double-blind, parallel-group, randomized controlled trial was performed to determine the efficacy and safety of a new first-line strategy in mild to moderate hypertension based on a single-pill combination of perindopril/amlodipine versus a validated stepped-care strategy (initiation with valsartan monotherapy, up-titrating to valsartan/amlodipine after 2 months). Methods: At inclusion, patients received perindopril/amlodipine 3.5/2.5 mg or valsartan 80 mg. At 1, 2, and 3 months, patients were up-titrated if they had uncontrolled hypertension (≥140/90 mmHg). The up-titration steps were...
Source: Journal of Hypertension - January 6, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs – Overview and meta-analyses
Conclusion: BP lowering by all classes of antihypertensive drugs is accompanied by significant reductions of stroke and major cardiovascular events. This supports the concept that reduction of these events is because of BP lowering per se rather than specific drug properties. However, evidence of risk reduction of other events and particularly mortality was obtained so far with some drug classes only. As a result of marked differences in the trial design, total cardiovascular risk, SBP/DBP differences and statistical power, comparisons of meta-analyses of different drug-specific placebo-controlled RCTs appear unwarranted. ...
Source: Journal of Hypertension - January 6, 2015 Category: Cardiology Tags: Reviews and Meta-Analyses Source Type: research

COPD and concomitant arterial hypertension: The efficacy and safety of slow-release formulation of indapamide
Treatment of COPD patients with concomitant arterial hypertension is associated with such significant complications as increasing of bronchial obstruction, hyperinflation, electrolytes balance changing and others.Aims: To investigate the efficacy and safety of slow-release (SR) formulation of indapamide in the treatment of COPD and concomitant hypertension.Methods: 33 out-patients with COPD and concomitant hypertension were recruited (27 male, mean age of 60.8±10.5, %FEV1 58.4±11.5%, index smoker 42.3±11.5). COPD duration was 10.5±3.5 years, hypertension duration was 14.3±7.4 years. All p...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Nersesyan, Z., Ovcharenko, S., Morozova, T. Tags: 1.12 Clinical Problems - COPD Source Type: research

Predicting the Effects of Blood Pressure-Lowering Treatment on Major Cardiovascular Events for Individual Patients With Type 2 Diabetes Mellitus: Results From Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation [Clinical Trials]
In conclusion, a multivariable treatment algorithm can identify those individuals who benefit most from blood pressure–lowering therapy in terms of ARR of major adverse cardiovascular events and may be used to guide treatment decisions in individual patients with diabetes. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00145925. (Source: Hypertension)
Source: Hypertension - December 10, 2014 Category: Cardiology Authors: van der Leeuw, J., Visseren, F. L. J., Woodward, M., Zoungas, S., Kengne, A. P., van der Graaf, Y., Glasziou, P., Hamet, P., MacMahon, S., Poulter, N., Grobbee, D. E., Chalmers, J. Tags: Cardiovascular Pharmacology, Type 2 diabetes Clinical Trials Source Type: research

Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension
Conclusion In patients requiring combination antihypertensive treatment, the regimen of perindopril alone or its FDC with Indapamide or amlodipine reduces blood pressure effectively, resulting in high rates of blood pressure control over the short term, with a low frequency of side effects including cough and pedal edema. (Source: Indian Heart Journal)
Source: Indian Heart Journal - November 29, 2014 Category: Cardiology Source Type: research

HPLC-PDA analysis of ACE-inhibitors, hydrochlorthiazide and indapamide utilizing Design of Experiments
Publication date: Available online 18 November 2014 Source:Arabian Journal of Chemistry Author(s): Eyad Rashed Dawud , Ashok K. Shakya A simple, rapid, precise, accurate and sensitive high performance liquid chromatographic method has been developed for simultaneous determination of ACE inhibitors with hydrochlorothiazide and indapamide in pharmaceutical formulations. ‘Design of Experiments’ (DoE) using ‘central composite design’ (CCD) was applied to facilitate method development and optimization. Mobile phase was optimized utilizing response surface methodology using Design Expert software. Chrom...
Source: Arabian Journal of Chemistry - November 18, 2014 Category: Chemistry Source Type: research