Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension.
Authors: Bergo KK, Larstorp AC, Hoffmann P, Hjørnholm U, Cataliotti A, Høieggen A, Rostrup M, Fadl Elmula FEM Abstract PURPOSE: Renal sympathetic denervation (RDN) is again gaining interest as recent well-designed trials have demonstrated reduced ambulatory blood pressure (BP) after RDN. However, the hemodynamic mechanisms have not been elucidated. We aimed for the first time to investigate the effect of RDN on the "Hallmark of Hypertension" namely increased systemic vascular resistance index (SVRI). MATERIALS AND METHODS: We investigated SVRI change in patients with true treatment-resis...
Source: Blood Pressure - July 8, 2020 Category: Hematology Tags: Blood Press Source Type: research

Smoking and overweight associated with masked uncontrolled hypertension: a Hypertension Optimal Treatment (HOT) Sub-Study.
Authors: Holanger M, Kjeldsen SE, Jamerson K, Julius S, HOT Study investigators Abstract PURPOSE: The Hypertension Optimal Treatment (HOT) Study investigated the relationship between target office diastolic blood pressure (BP) ≤80, ≤85 or ≤90 mmHg and cardiovascular morbidity and mortality in 18,790 patients aged 50-80 years. The home BP sub-study enrolled 926 patients and the aim was to clarify whether the separation into the BP target groups in the office prevailed in the out-of-office setting. The present study aimed to identify variables that characterised masked uncontrolled hypertension...
Source: Blood Pressure - July 8, 2020 Category: Hematology Tags: Blood Press Source Type: research

Systemic vascular resistance predicts the development of hypertension: the cardiovascular risk in young Finns study.
Authors: Kähönen E, Lyytikäinen LP, Aatola H, Koivistoinen T, Haarala A, Sipilä K, Juonala M, Lehtimäki T, Raitakari OT, Kähönen M, Hutri-Kähönen N Abstract Purpose: To study whether systemic hemodynamics, especially systemic vascular resistance, predicts the development of hypertension and improves the risk prediction of incident hypertension beyond common risk factors in the risk models in young adults.Materials and methods: Typical risk factors for hypertension in the risk prediction models (systolic and diastolic blood pressure, parental history of hypertension, age,...
Source: Blood Pressure - July 2, 2020 Category: Hematology Tags: Blood Press Source Type: research

Evaluation of time delay between discovery of a high blood pressure in a health screening survey and hypertension diagnosis.
Conclusion: In conclusion, when an elevated blood pressure was discovered in elderly persons at a health screening, 70% of those received a hypertension diagnosis within 10 years, with a mean time to diagnosis of 5 years. Health care actions should be enforced to shorten this time lag both in terms of information to the individuals, as well as the handling of this patient group in primary care. PMID: 32603237 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - July 2, 2020 Category: Hematology Tags: Blood Press Source Type: research

Ambulatory blood pressure monitoring by a novel cuffless device: a pilot study.
Authors: Scalise F, Margonato D, Sole A, Sorropago A, Sorropago G, Mancia G Abstract Purpose: Cuffless blood pressure (CL-BP) measurements are believed to be a potentially alternative to cuff-occlusion-based (C-BP) measurement. A new cuffless device was developed for ambulatory BP monitoring. We assessed the accuracy of a new CL-BP device compared to a standard oscillatory C-BP device over the 24 h.Materials and methods: Eighty-four consecutive patients were included in the study. BP was measured simultaneously by the CL-BP device and by a C-BP device over the 24 h. Calculations included 24 h m...
Source: Blood Pressure - July 2, 2020 Category: Hematology Tags: Blood Press Source Type: research

On-treatment HDL cholesterol predicts incident atrial fibrillation in hypertensive patients with left ventricular hypertrophy.
Conclusion: Lower on-treatment HDL is strongly associated with risk of new AF. These findings suggest that serial assessment of HDL can estimate AF risk better than baseline HDL in hypertensive patients with left ventricular hypertrophy. Future studies may investigate whether therapies that increase HDL can lower risk of developing AF.Clinical Trials Registration: http://clinicaltrials.gov/ct/show/NCT00338260?order=1. PMID: 32586143 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - June 28, 2020 Category: Hematology Tags: Blood Press Source Type: research

Intensive systolic blood pressure control and prevention of new onset atrial fibrillation in the SPRINT study: is the association really controversial?
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 32584173 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - June 27, 2020 Category: Hematology Tags: Blood Press Source Type: research

Antihypertensive prescription patterns and cardiovascular risk in patients with newly diagnosed hypertension- an analysis of statutory health insurance data in Germany.
Conclusion: Initial treatment strategies may not always be stratified according to cardiovascular risk. The majority of patients with hypertension receives initial monotherapy independent of their individual risk. However, combination therapy represents the major form of therapy in the long-term. PMID: 32543915 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - June 18, 2020 Category: Hematology Tags: Blood Press Source Type: research

Changes of augmentation index early after ischaemic stroke predict functional outcome.
Conclusions: Rise in AIx within one week after ischaemic stroke may be of additional importance in determining better early and late favourable functional outcome. PMID: 32456469 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 29, 2020 Category: Hematology Tags: Blood Press Source Type: research

Subclinical macroangiopathic target organ damage in type 1 diabetes mellitus patients.
Conclusions: There is shortage of data from prospective studies which could confirm the benefits of early treatment initiation based on the presence of the subclinical organ damage in T1DM. Most evidence comes from T2DM trials, where effective preventive measures were identified i.e.: smoking cessation, reasonable blood glucose control, efficacious hypertension treatment, and dyslipidemia management, as well as renoprotection. There is still a field for further research to see if routine assessment of asymptomatic vascular damage and early implementation of aggressive treatment would reduce mortality excess from CVD in T1D...
Source: Blood Pressure - May 29, 2020 Category: Hematology Tags: Blood Press Source Type: research

Impending hypertensive emergency is frequently considered in guidelines, but neither defined nor explained.
Authors: Koracevic G, Stojanovic M, Lovic D, Djordjevic D PMID: 32441140 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 23, 2020 Category: Hematology Tags: Blood Press Source Type: research

Longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease in hypertensive and normotensive adults.
Authors: Krajčoviechová A, Wohlfahrt P, Bruthans J, Šulc P, Lánská V, Borghi C, Cífková R Abstract The purpose: To evaluate longitudinal trends in the prevalence of hyperuricaemia and chronic kidney disease (CKD) in Czech adults with and without arterial hypertension (HT).Materials and methods: Two independent cross-sectional surveys were performed in 2006-2009 and 2015-2018, each screening involving 1% population random sample of the general population of nine districts of the Czech Republic aged 25-64 years, stratified by age and gender. Hyperuricaemia was defined...
Source: Blood Pressure - May 21, 2020 Category: Hematology Tags: Blood Press Source Type: research

Subtypes of masked hypertension and target organ damage in untreated outpatients.
Authors: Zhang DY, Cheng YB, Guo QH, Wang Y, Sheng CS, Huang QF, An DW, Li MX, Huang JF, Xu TY, Wang JG, Li Y Abstract Purpose: Masked hypertension (MHT) is characterised as an office normotension in the presence of out-of-office hypertension, and can be further categorised as isolated daytime (dMHT), night-time (nMHT) or day-night MHT (dnMHT) according to the time when hypertension is present. MHT is associated with adverse cardiovascular outcome. However, no previous studies contrasted these MHT subtypes in their associations with target organ damage (TOD).Materials and methods: Consecutive untreated patients ref...
Source: Blood Pressure - May 15, 2020 Category: Hematology Tags: Blood Press Source Type: research

Assessment of adherence to diuretics and β-blockers by serum drug monitoring in comparison to urine analysis.
Conclusion: This study suggests that assessment of adherence can be performed more precisely on the basis of serum drug concentrations with individually calculated lower DRC than by using the TRR or qualitative urinalysis. PMID: 32400211 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 15, 2020 Category: Hematology Tags: Blood Press Source Type: research

Factors associated with increase in blood pressure and incident hypertension in early midlife: the Hordaland Health Study.
Authors: Kringeland E, Tell GS, Midtbø H, Haugsgjerd TR, Igland J, Gerdts E Abstract Purpose: We aimed to identify sex-specific factors associated with increase in blood pressure (BP) and incident hypertension in early midlife.Materials and methods: 2,008 women and 1,610 men aged 40-43 years were followed for six years in the Hordaland Health Study. Participants taking antihypertensive medication at baseline were excluded. High-normal BP was defined as baseline BP 130-139/85-89 mmHg, and incident hypertension as BP≥140/90 mmHg or use of antihypertensive medication at follow-up.Results: During follow-up, a...
Source: Blood Pressure - May 15, 2020 Category: Hematology Tags: Blood Press Source Type: research

Results of renal artery revascularization in the post-ASTRAL era with 4 years mean follow-up.
Authors: Zachrisson K, Krupic F, Svensson M, Wigelius A, Jonsson A, Dimopoulou A, Stenborg A, Jensen G, Herlitz H, Gottsäter A, Falkenberg M Abstract Purpose: To investigate contemporary results of percutaneous transluminal renal angioplasty (PTRA).Materials and Methods: A multicentre retrospective study analysing all patients treated with PTRA for primary symptomatic renal artery stenosis (RAS) between 2010 and 2013 at four tertiary centres. Procedures during the preceding four years were counted to evaluate for change in PTRA frequency.Results: The number of PTRA procedures decreased by approximately 50% fro...
Source: Blood Pressure - May 6, 2020 Category: Hematology Tags: Blood Press Source Type: research

Prevalence, awareness, treatment and control of hypertension in various ethnic groups (Hui, Kazakh, Kyrgyz, Mongolian, Tajik) in Xinjiang, Northwest China.
Conclusions: Hypertension is moderately prevalent in Xinjiang, whereas poorly controlled. Standardization of its treatment such as introducing treatment algorithm might be the priorities for future improvement, with healthy life promotion. PMID: 32349556 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 2, 2020 Category: Hematology Tags: Blood Press Source Type: research

Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project.
Authors: Kreutz R, Kjeldsen SE, Burnier M, Narkiewicz K, Oparil S, Mancia G PMID: 32338542 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - April 29, 2020 Category: Hematology Tags: Blood Press Source Type: research

Pulse wave velocity is related to exercise blood pressure response in young adults. The Cardiovascular Risk in Young Finns Study.
This study consisted of 209 young adults (mean age 38 years) who participated in the ongoing Cardiovascular Risk in Young Finns Study between 2007 and 2009. We measured resting PWV with impedance cardiography in 2007, and participants performed a maximal cardiopulmonary exercise test with blood pressure (BP) measurements at rest, during exercise and during recovery in 2008-2009.Results: High PWV (≥age- and sex-specific median) at baseline was associated with EEBP (SBP>210 mmHg for men and>190 mmHg for women) an average of 14 months later and with systolic BP during different stages of e...
Source: Blood Pressure - April 16, 2020 Category: Hematology Tags: Blood Press Source Type: research

Influence of pre-treatment blood pressure levels on antihypertensive drug benefits in diabetics: the roadmap experience.
Authors: Chatzikyrkou C, Scourt FG, Menne J, Korda A, Mertens PR, Haller H Abstract Purpose: Most guidelines for treatment of hypertension in the setting of diabetes recommend a blood pressure (BP) target of
Source: Blood Pressure - April 15, 2020 Category: Hematology Tags: Blood Press Source Type: research

Lumen narrowing and increased wall to lumen ratio of retinal microcirculation are valuable biomarkers of hypertension-mediated cardiac damage.
Authors: Dąbrowska E, Harazny JM, Miszkowska-Nagórna E, Stefański A, Graff B, Kunicka K, Świerblewska E, Rojek A, Szyndler A, Wolf J, Gruchała M, Schmieder RE, Narkiewicz K Abstract Purpose: In the course of hypertension, left ventricular hypertrophy and diastolic dysfunction develop very often and may progress toward heart failure. The aim of the study was to analyze the relationship between abnormalities of retinal microcirculation and cardiac damage defined as left ventricular hypertrophy and/or diastolic dysfunction.Materials and methods: The study comprised 88 patients with essential hypertension. T...
Source: Blood Pressure - April 2, 2020 Category: Hematology Tags: Blood Press Source Type: research

Effect of the shape of the cuff on blood pressure measurement in people with large arms.
Authors: Palatini P, Benetti E, Fania C, Ermolao A, Spinella P, Battista F, Gasperetti A, Saladini F Abstract Purpose: Previous data suggest that tronco-conical cuffs should be used for accurate blood pressure (BP) measurement in the obese. However, not only arm size but also its shape may affect the accuracy of BP measurement when a cylindrical cuff is used.Methods: In 197 subjects with arm circumference>32 cm, and 157 subjects with arm circumference ≤ 32 cm, the upper-arm was considered as formed from two truncated cones and the frustum slant angles of the proximal (upper angle) and distal (mi...
Source: Blood Pressure - March 17, 2020 Category: Hematology Tags: Blood Press Source Type: research

Association between antecedent blood pressure, hypertension-mediated organ damage and cardiovascular outcome.
The objective of this study was to test if combining antecedent systolic blood pressure (SBP) with traditional risk factors and hypertension-mediated organ damage (HMOD) improves risk stratification for subsequent cardiovascular disease.Materials and methods: 1910 subjects participated in this study. Antecedent SBP was defined as the average of measurements obtained in 1982 and in 1987. Current SBP was obtained in 1993. HMOD were examined in 1993. HMOD was defined as either atherosclerotic plaque(s), increased pulse wave velocity, increased urine albumin creatinine ratio (above the 90th percentile) or left ventricular hype...
Source: Blood Pressure - March 13, 2020 Category: Hematology Tags: Blood Press Source Type: research

Delayed versus classic orthostatic hypotension: clinical and prognostic implications.
Authors: Tzur I, Barchel D, Khateb Z, Swarka M, Izhakian S, Gorelik O Abstract Purpose: Orthostatic hypotension (OH) is a common disorder, especially among hospitalised patients. Classic OH is defined as occurring 3 or less minutes of orthostatic stress, and delayed OH as occurring after 3 min of stress. We aimed to compare clinical characteristics and prognosis between inpatients with classic vs. delayed OH.Methods: We performed a retrospective analysis of data from 358 inpatients, aged ≥60 years, who were evaluated for the occurrence of OH at the initial phase of ambulation in four previous prosp...
Source: Blood Pressure - March 7, 2020 Category: Hematology Tags: Blood Press Source Type: research

Association between uric acid and pulse wave velocity in hypertensive patients and in the general population: a systematic review and meta-analysis.
Conclusion: The association between SUA and cf-PWV resulted significant in general population in both males and females while it was only significant for female regarding ba-PWV. Furthermore, the few available studies found no significant relationship between SUA and both cf- and ba-PWV in hypertensive subjects. PMID: 32138547 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - March 7, 2020 Category: Hematology Tags: Blood Press Source Type: research

Screening for hypertension at the hairdresser: a feasibility study in France and Morocco.
Authors: Boivin JM, Risse J, Laurière E, Burnier M Abstract Purpose: Worldwide, hypertension awareness remains largely insufficient. This is particularly true in some population subgroups with a low socioeconomic status or in young adults who have limited interactions with healthcare systems. Performing Blood Pressure (BP) screening in non-conventional settings, such as in barbershops, has been suggested by a number of American authors. Whether this approach is feasible in Europe or in North Africa has not been evaluated, however. We, therefore, undertook a study to assess the value of BP screening at hairdr...
Source: Blood Pressure - February 16, 2020 Category: Hematology Tags: Blood Press Source Type: research

How to deal with the occurrence of rare drug-induced adverse events: the example of sprue-like enteropathy induced by olmesartan medoxomil and other angiotensin-receptor blockers.
Authors: Burnier M, Kjeldsen SE, Narkiewicz K, Oparil S PMID: 32049554 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - February 14, 2020 Category: Hematology Tags: Blood Press Source Type: research

Primary aldosteronism in a general population sample. The Czech post-MONICA study.
Conclusion: Elevated serum aldosterone together with low renin and high ARR were found in 52 (8%) of hypertensives selected from a general population sample, however, the diagnosis of PA was confirmed only in 13 of them (2%). This study based on a general population survey highlighted the difficulty of conducting epidemiological studies on primary aldosteronism in a relatively healthy cohort part of whom did not provide the level of collaboration that is necessary to assess the true prevalence of this condition. PMID: 32036692 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - February 12, 2020 Category: Hematology Tags: Blood Press Source Type: research

Cardiovascular risk factors as determinants of cerebral blood flow - a cross-sectional and 6-year follow-up study.
Authors: Kwater A, Gąsowski J, Wizner B, Kasprzyk Z, Cwynar M, Rewiuk K, Grodzicki T Abstract Purpose: The parameters of cerebral blood flow are modulated by many factors. The aim of the study was to prospectively assess the relationship between the number of the established cardiovascular risk factors and hemodynamic parameters of cerebral blood flow.Material and methods: The study was cross-sectional baseline and 6-year follow-up data analysis. We analyzed data regarding cardiovascular risk factors, medications use, and ultrasonographically (transcranial Doppler) obtained mean cerebral blood flow velocity (mCBFV...
Source: Blood Pressure - January 29, 2020 Category: Hematology Tags: Blood Press Source Type: research

The effect of an exam period as a stress situation on baroreflex sensitivity among healthy university students.
Authors: Fejes I, Ábrahám G, Légrády P Abstract Purpose: Authors investigated the effect of a university exam period on blood pressure (BP) and baroreflex-sensitivity (BRS) among healthy students.Materials and methods: Fifty-three healthy normotensive university students participated in the test. BP values and BRS were recorded once during a 14-week long semester and once during a 6-week long exam period with a Finometer device. The time-domain spontaneous BRS in lying position and after standing up was calculated with Nevrokard software. Students were divided into optimal, normal, high-...
Source: Blood Pressure - January 16, 2020 Category: Hematology Tags: Blood Press Source Type: research

The Health Outcomes Prevention and Evaluation 4 (HOPE 4) project: A successful community-based intervention to lower cardiovascular risk in people with hypertension.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31902246 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - January 7, 2020 Category: Hematology Tags: Blood Press Source Type: research

Current antihypertensive drug therapy in 12,436 Swedish patients, 90 years and above, in relation to sex and comorbidity.
Authors: Wallentin F, Wettermark B, Kahan T Abstract Purpose: To describe current antihypertensive treatment in very old hypertensive patients according to sex and comorbidity.Materials and methods: We used the Stockholm regional healthcare data warehouse (Vårdanalysdatabasen) providing information on all healthcare consultations, diagnoses, hospitalizations, dispensed prescription drugs, sex and age in 2.1 million people living in the greater Stockholm region, Sweden. This cross-sectional analysis identified 12,436 individuals with a diagnosis of hypertension, who were 90 years or older.Results: Mean ag...
Source: Blood Pressure - December 28, 2019 Category: Hematology Tags: Blood Press Source Type: research

Identifying poor cardiorespiratory fitness in overweight and obese children and adolescents by using heart rate variability analysis under resting conditions.
Conclusions: A screening tool based on heart rate variability and anthropometric parameters was developed to identify subjects with higher probability of suffering or developing cardio metabolic risk factors. PMID: 31829032 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - December 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

Central hemodynamics in relation to low-level environmental lead exposure.
Conclusion: In conclusion, low-level environmental lead exposure possibly contributes to arterial stiffening and wave reflection from peripheral sites. PMID: 31833420 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - December 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

PERson-centredness in hypertension management using information technology (PERHIT): a protocol for a randomised controlled trial in primary health care.
Conclusion: The results of this randomised controlled trial with assessment of blood pressure and same-day self-reports will provide patients a tool to understand the interplay between blood pressure and lifestyle applicable to primary health care. The self-management support system may be of importance for improved adherence to treatment and persistence to treatment recommendations. PMID: 31814476 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - December 11, 2019 Category: Hematology Tags: Blood Press Source Type: research

Plasma total calcium concentration is associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects.
Authors: Oinonen L, Koskela J, Eräranta A, Tikkakoski A, Kähönen M, Niemelä O, Mustonen J, Pörsti I Abstract Purpose: The underlying causes of primary hypertension are not fully understood. Evidence on the relation of plasma calcium concentration with blood pressure (BP) is inconsistent and relies largely on studies utilizing office BP measurements in populations using cardiovascular drugs. In many studies adjustment for confounders was not optimal. In this cross-sectional study we examined the association of plasma total calcium concentration with the haemodynamic determinants of blood pre...
Source: Blood Pressure - December 4, 2019 Category: Hematology Tags: Blood Press Source Type: research

Blood pressure-related electrocardiographic findings in healthy young individuals.
Authors: Hassing GJ, van der Wall HEC, van Westen GJP, Kemme MJB, Adiyaman A, Elvan A, Burggraaf J, Gal P Abstract Purpose: Elevated blood pressure induces electrocardiographic changes and is associated with an increase in cardiovascular disease later in life compared to normal blood pressure levels. The purpose of this study was to evaluate the association between normal to high normal blood pressure values (90-139/50-89 mmHg) and electrocardiographic parameters related to cardiac changes in hypertension in healthy young adults.Methods: Data from 1449 volunteers aged 18-30 years collected at our cent...
Source: Blood Pressure - November 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

The association between orthostatic hypotension and cognition and stroke: a meta-analysis of prospective cohort studies.
Conclusion: This meta-analysis provides evidence that OH was associated with worse cognition. OH accounted for a 30% increase in the risk of dementia and a 36% increase in the risk of stroke. PMID: 31718311 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study.
Conclusions: The present study seeks to provide new insight in the pathophysiological mechanisms linking reduced kidney function to cardiovascular disease. In addition, we aim to enlighten predictors of adverse cardiovascular outcome in living kidney donors. The study is registered at Clinical-Trials.gov (identifier: NCT03729557). PMID: 31718316 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

Over-the-counter mouthwash use, nitric oxide and hypertension risk.
Conclusion: In this study, frequent regular use of over-the-counter mouthwash was associated with increased risk of hypertension, independent of major risk factors for hypertension and several other potential confounders. PMID: 31709856 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 13, 2019 Category: Hematology Tags: Blood Press Source Type: research

Lower utilization of home blood pressure monitoring in younger, poorly educated hypertensive males - real-life data.
Authors: Chudek A, Owczarek AJ, Ficek J, Almgren-Rachtan A, Chudek J Abstract Background: Home blood pressure monitoring (HBPM) became a standard in the management of hypertension. However, there are few data concerning the utilisation of blood pressure (BP) monitors in daily clinical practice.Aim: The aim of this analysis was to show: (1) how frequently hypertensive patients are equipped with BP monitors, (2) how often they perform regular HBPM and running BP diaries, (3) what are the correlates of utilisation of BP monitors, in a large real-life cohort of hypertensives examined for the efficacy of antihypertensiv...
Source: Blood Pressure - November 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

Soluble RAGEs and cardiovascular risk factors in adult offspring of patients with premature coronary heart disease.
Conclusion: Offspring of patients with early onset of CHD compared to age-matched healthy controls had significantly lower sRAGE levels suggesting a shift in the oxidative balance between stressors and defence mechanisms that may influence a higher cardiovascular risk in the future. The measurement of sRAGE might be a valuable predictor for more precise stratification of cardiovascular risk. PMID: 31691578 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

A randomized controlled trial on ambulatory blood pressure lowering effect of CPAP in patients with obstructive sleep apnea and nocturnal hypertension.
Conclusions: The CPAP treatment did not show significant ambulatory BP lowering effect in patients with moderate-severe OSAS and nocturnal hypertension. However, it may be effective in lowering daytime BP in patients with a faster pulse rate. PMID: 31696741 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

Systolic blood pressure control prevents cognitive decline and slows development of white matter lesions in the brain: the SPRINT MIND study outcomes.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31623467 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - October 20, 2019 Category: Hematology Tags: Blood Press Source Type: research

Masked hypertension is associated with end organ damage in geriatric age: Geriatric MASked Hypertension and End organ damage (G-MASH-End organ Study).
Conclusion: MH is associated with end-organ damage in geriatric patients. Urinary albumin excretion and LVH which are the parameters of end-organ damage were significantly higher in MH patients. MH may cause end-organ damage and should not be overlooked in geriatric patients. PMID: 31607165 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - October 15, 2019 Category: Hematology Tags: Blood Press Source Type: research

The PARAGON-Heart failure trial - another disappointment for heart failure patients with hypertension and preserved ejection fraction.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31542958 [PubMed - in process] (Source: Blood Pressure)
Source: Blood Pressure - September 25, 2019 Category: Hematology Tags: Blood Press Source Type: research

A case of an extreme white coat effect.
In this report, we present a challenging case of a 63-year-old Caucasian woman with an extreme stress response to blood pressure (BP) measurements. Office- and ambulatory BP measurements consistently found systolic BP above 200 mmHg. However, antihypertensive medication made her dizzy and extremely unwell, and she could barely tolerate treatment with a moderate dose of angiotensin-converting enzyme (ACE) inhibitor. Finger-cuff-based measurements (Finapres Finometer®) revealed extreme hypertension in relation to contact with medical professionals, but hypotension when the patient was seated alone unobserved. Mont...
Source: Blood Pressure - August 29, 2019 Category: Hematology Tags: Blood Press Source Type: research

The intensity of oscillations of the photoplethysmographic waveform variability at frequencies 0.04-0.4  Hz is effective marker of hypertension and coronary artery disease in males.
The intensity of oscillations of the photoplethysmographic waveform variability at frequencies 0.04-0.4 Hz is effective marker of hypertension and coronary artery disease in males. Blood Press. 2019 Aug 12;:1-8 Authors: Kiselev AR, Karavaev AS Abstract Background: It is believed that the intensity of oscillations in the photoplethysmographic waveform variability reflects the activity of vascular regulatory mechanisms. However, the relationship of such fluctuations with the state of health is poorly understood. Purpose: The aim of our study was to assess the possibility of using spectral indices ...
Source: Blood Pressure - August 15, 2019 Category: Hematology Tags: Blood Press Source Type: research

The impact of pulsed electromagnetic field therapy on blood pressure and circulating nitric oxide levels: a double blind, randomized study in subjects with metabolic syndrome.
Authors: Kim CH, Wheatley-Guy CM, Stewart GM, Yeo D, Shen WK, Johnson BD Abstract Purpose: Regulation of blood pressure (BP) is important in reducing the risk for cardiovascular disease. There is growing interest in non-pharmacological methods to treat BP including a novel approach using pulsed electromagnetic field therapy (PEMF). PEMF therapy has been proposed to impact physiological function at the cellular and tissue level and one possible mechanism is through an impact on endothelial function and nitric oxide (NO) related pathways. The focus of the present study was to evaluate the effect of PEMF on BP and NO ...
Source: Blood Pressure - August 11, 2019 Category: Hematology Tags: Blood Press Source Type: research

Effect of angiotensin receptor blockers on blood pressure and renal function in patients with concomitant hypertension and chronic kidney disease: a systematic review and meta-analysis.
Authors: Burnier M, Lin S, Ruilope L, Bader G, Durg S, Brunel P Abstract Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or without diabetes. Methods: Literature search was performed in PubMed/MEDLINE, EMBASE and BIOSIS to identify parallel-group, randomized controlled trials (≥8 weeks) reporting the effects of ARB on office systolic/diastolic BP (SBP/DBP...
Source: Blood Pressure - August 9, 2019 Category: Hematology Tags: Blood Press Source Type: research