PERson-centredness in hypertension management using information technology (PERHIT): a protocol for a randomised controlled trial in primary health care.
Conclusion: The results of this randomised controlled trial with assessment of blood pressure and same-day self-reports will provide patients a tool to understand the interplay between blood pressure and lifestyle applicable to primary health care. The self-management support system may be of importance for improved adherence to treatment and persistence to treatment recommendations. PMID: 31814476 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - December 11, 2019 Category: Hematology Tags: Blood Press Source Type: research

Plasma total calcium concentration is associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects.
Authors: Oinonen L, Koskela J, Eräranta A, Tikkakoski A, Kähönen M, Niemelä O, Mustonen J, Pörsti I Abstract Purpose: The underlying causes of primary hypertension are not fully understood. Evidence on the relation of plasma calcium concentration with blood pressure (BP) is inconsistent and relies largely on studies utilizing office BP measurements in populations using cardiovascular drugs. In many studies adjustment for confounders was not optimal. In this cross-sectional study we examined the association of plasma total calcium concentration with the haemodynamic determinants of blood pre...
Source: Blood Pressure - December 4, 2019 Category: Hematology Tags: Blood Press Source Type: research

Blood pressure-related electrocardiographic findings in healthy young individuals.
Authors: Hassing GJ, van der Wall HEC, van Westen GJP, Kemme MJB, Adiyaman A, Elvan A, Burggraaf J, Gal P Abstract Purpose: Elevated blood pressure induces electrocardiographic changes and is associated with an increase in cardiovascular disease later in life compared to normal blood pressure levels. The purpose of this study was to evaluate the association between normal to high normal blood pressure values (90-139/50-89 mmHg) and electrocardiographic parameters related to cardiac changes in hypertension in healthy young adults.Methods: Data from 1449 volunteers aged 18-30 years collected at our cent...
Source: Blood Pressure - November 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

The association between orthostatic hypotension and cognition and stroke: a meta-analysis of prospective cohort studies.
Conclusion: This meta-analysis provides evidence that OH was associated with worse cognition. OH accounted for a 30% increase in the risk of dementia and a 36% increase in the risk of stroke. PMID: 31718311 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study.
Conclusions: The present study seeks to provide new insight in the pathophysiological mechanisms linking reduced kidney function to cardiovascular disease. In addition, we aim to enlighten predictors of adverse cardiovascular outcome in living kidney donors. The study is registered at Clinical-Trials.gov (identifier: NCT03729557). PMID: 31718316 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 14, 2019 Category: Hematology Tags: Blood Press Source Type: research

Over-the-counter mouthwash use, nitric oxide and hypertension risk.
Conclusion: In this study, frequent regular use of over-the-counter mouthwash was associated with increased risk of hypertension, independent of major risk factors for hypertension and several other potential confounders. PMID: 31709856 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 13, 2019 Category: Hematology Tags: Blood Press Source Type: research

Lower utilization of home blood pressure monitoring in younger, poorly educated hypertensive males - real-life data.
Authors: Chudek A, Owczarek AJ, Ficek J, Almgren-Rachtan A, Chudek J Abstract Background: Home blood pressure monitoring (HBPM) became a standard in the management of hypertension. However, there are few data concerning the utilisation of blood pressure (BP) monitors in daily clinical practice.Aim: The aim of this analysis was to show: (1) how frequently hypertensive patients are equipped with BP monitors, (2) how often they perform regular HBPM and running BP diaries, (3) what are the correlates of utilisation of BP monitors, in a large real-life cohort of hypertensives examined for the efficacy of antihypertensiv...
Source: Blood Pressure - November 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

Soluble RAGEs and cardiovascular risk factors in adult offspring of patients with premature coronary heart disease.
Conclusion: Offspring of patients with early onset of CHD compared to age-matched healthy controls had significantly lower sRAGE levels suggesting a shift in the oxidative balance between stressors and defence mechanisms that may influence a higher cardiovascular risk in the future. The measurement of sRAGE might be a valuable predictor for more precise stratification of cardiovascular risk. PMID: 31691578 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

A randomized controlled trial on ambulatory blood pressure lowering effect of CPAP in patients with obstructive sleep apnea and nocturnal hypertension.
Conclusions: The CPAP treatment did not show significant ambulatory BP lowering effect in patients with moderate-severe OSAS and nocturnal hypertension. However, it may be effective in lowering daytime BP in patients with a faster pulse rate. PMID: 31696741 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - November 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

Systolic blood pressure control prevents cognitive decline and slows development of white matter lesions in the brain: the SPRINT MIND study outcomes.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31623467 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - October 20, 2019 Category: Hematology Tags: Blood Press Source Type: research

Masked hypertension is associated with end organ damage in geriatric age: Geriatric MASked Hypertension and End organ damage (G-MASH-End organ Study).
Conclusion: MH is associated with end-organ damage in geriatric patients. Urinary albumin excretion and LVH which are the parameters of end-organ damage were significantly higher in MH patients. MH may cause end-organ damage and should not be overlooked in geriatric patients. PMID: 31607165 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - October 15, 2019 Category: Hematology Tags: Blood Press Source Type: research

The PARAGON-Heart failure trial - another disappointment for heart failure patients with hypertension and preserved ejection fraction.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31542958 [PubMed - in process] (Source: Blood Pressure)
Source: Blood Pressure - September 25, 2019 Category: Hematology Tags: Blood Press Source Type: research

A case of an extreme white coat effect.
In this report, we present a challenging case of a 63-year-old Caucasian woman with an extreme stress response to blood pressure (BP) measurements. Office- and ambulatory BP measurements consistently found systolic BP above 200 mmHg. However, antihypertensive medication made her dizzy and extremely unwell, and she could barely tolerate treatment with a moderate dose of angiotensin-converting enzyme (ACE) inhibitor. Finger-cuff-based measurements (Finapres Finometer®) revealed extreme hypertension in relation to contact with medical professionals, but hypotension when the patient was seated alone unobserved. Mont...
Source: Blood Pressure - August 29, 2019 Category: Hematology Tags: Blood Press Source Type: research

The intensity of oscillations of the photoplethysmographic waveform variability at frequencies 0.04-0.4  Hz is effective marker of hypertension and coronary artery disease in males.
The intensity of oscillations of the photoplethysmographic waveform variability at frequencies 0.04-0.4 Hz is effective marker of hypertension and coronary artery disease in males. Blood Press. 2019 Aug 12;:1-8 Authors: Kiselev AR, Karavaev AS Abstract Background: It is believed that the intensity of oscillations in the photoplethysmographic waveform variability reflects the activity of vascular regulatory mechanisms. However, the relationship of such fluctuations with the state of health is poorly understood. Purpose: The aim of our study was to assess the possibility of using spectral indices ...
Source: Blood Pressure - August 15, 2019 Category: Hematology Tags: Blood Press Source Type: research

The impact of pulsed electromagnetic field therapy on blood pressure and circulating nitric oxide levels: a double blind, randomized study in subjects with metabolic syndrome.
Authors: Kim CH, Wheatley-Guy CM, Stewart GM, Yeo D, Shen WK, Johnson BD Abstract Purpose: Regulation of blood pressure (BP) is important in reducing the risk for cardiovascular disease. There is growing interest in non-pharmacological methods to treat BP including a novel approach using pulsed electromagnetic field therapy (PEMF). PEMF therapy has been proposed to impact physiological function at the cellular and tissue level and one possible mechanism is through an impact on endothelial function and nitric oxide (NO) related pathways. The focus of the present study was to evaluate the effect of PEMF on BP and NO ...
Source: Blood Pressure - August 11, 2019 Category: Hematology Tags: Blood Press Source Type: research

Effect of angiotensin receptor blockers on blood pressure and renal function in patients with concomitant hypertension and chronic kidney disease: a systematic review and meta-analysis.
Authors: Burnier M, Lin S, Ruilope L, Bader G, Durg S, Brunel P Abstract Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or without diabetes. Methods: Literature search was performed in PubMed/MEDLINE, EMBASE and BIOSIS to identify parallel-group, randomized controlled trials (≥8 weeks) reporting the effects of ARB on office systolic/diastolic BP (SBP/DBP...
Source: Blood Pressure - August 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

Electrocardiographic left ventricular hypertrophy in relation to peripheral and central blood pressure indices in a Nigerian population.
Authors: Odili AN, Chori BS, Danladi B, Yang WY, Zhang ZY, Thijs L, Wei FF, Nawrot TS, Kuznetsova T, Staessen JA Abstract Purpose: Previous studies that addressed whether left ventricular hypertrophy is more closely associated with central than peripheral blood pressure (BP) have been inconsistent. Radial artery wave generated by applanation tonometry and calibrated with brachial BP in 162 adult Nigerians were analysed by using generalized transfer function to derive central BP. Materials and methods: We compared the associations of ECG voltages and left ventricular hypertrophy (ECG-LVH) as continuous and binary va...
Source: Blood Pressure - July 30, 2019 Category: Hematology Tags: Blood Press Source Type: research

Relation of the renin-angiotensin-aldosterone system with potential cardiac injury and remodelling: the SABPA study.
This study investigated the associations of cardiac troponin T (cTnT), N-terminal pro-brain natriuretic peptide (NTproBNP) and subclinical LVH with components of the RAAS (renin, aldosterone and aldosterone-to-renin ratio (ARR)) and copeptin in a black and white South African cohort. Materials and methods: The study population consisted of 305 participants (black = 139, white = 166) aged 20-62 years. Serum cTnT, NTproBNP, Cornell product, components of the RAAS (active renin, aldosterone and ARR) and copeptin were determined. Results: The black group had lower renin (p 
Source: Blood Pressure - July 26, 2019 Category: Hematology Tags: Blood Press Source Type: research

Added value of aortic pulse wave velocity index for the detection of coronary heart disease by elective coronary angiography.
Authors: Vallée A, Zhang Y, Protogerou A, Safar ME, Blacher J Abstract Background: Non-invasive tests leading to elective coronary angiography (CAG) have low diagnostic yield for obstructive coronary heart disease (CHD). Aortic stiffness, an independent predictor of CHD events can be easily measured by pulse wave velocity (PWV). We aimed at retrospectively evaluating the diagnostic accuracy PWV index to detect CHD in consecutive patients with suspected CHD that underwent CAG. Method: In population of 86 healthy patients with available PWV data, a theoretical PWV was derived. In different population of 62 ind...
Source: Blood Pressure - July 13, 2019 Category: Hematology Tags: Blood Press Source Type: research

Influence of quality of sleep in the first trimester on blood pressure in the third trimester in primipara women.
Authors: Okada K, Saito I, Katada C, Tsujino T Abstract Purpose: The purpose of this study was to clarify the relationship between decreased sleep quality during the first trimester and a rise in blood pressure during an otherwise normal course of pregnancy in primipara women. Materials and methods: We recruited 128 pregnant women (primipara) who visited the obstetrics and gynecology clinic for medical examination, of which 89 were longitudinally investigated from the first to the third trimester after obtaining informed consent. A survey was conducted in the first, second, and third trimesters to evaluate sleep qu...
Source: Blood Pressure - July 5, 2019 Category: Hematology Tags: Blood Press Source Type: research

Predictors of blood pressure control in patients with resistant hypertension after intensive management in two expert centres: the Brussels-Torino experience.
Authors: Pappaccogli M, Di Monaco S, Coralie G, Petit G, Eula E, Ritscher S, Lengelé JP, Fanelli E, Severino F, Renkin J, Avataneo V, Wallemacq P, Toennes SW, de Timary P, Rabbia F, Persu A Abstract Background: Management of resistant hypertension (RHTN) is challenging and often implies the use of complex polypharmacy and interventional therapies. The main objectives of this study were (i) to describe the characteristics of patients with RHTN referred to two expert centres; (ii) to identify predictors of blood pressure (BP) control after intensive management. Methods: We reviewed electronic medical files of ...
Source: Blood Pressure - July 3, 2019 Category: Hematology Tags: Blood Press Source Type: research

Antihypertensive therapy prevents new-onset atrial fibrillation in patients with isolated systolic hypertension: the LIFE study.
Conclusion: Our data suggest that the effect of in-treatment SBP reduction in preventing new-onset AF is stronger in ISH compared to non-ISH patients with hypertension and ECG-LVH. However, the principal findings were the same in ISH and non-ISH patients. PMID: 31259628 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - July 3, 2019 Category: Hematology Tags: Blood Press Source Type: research

Directly observed therapy prior to ambulatory blood pressure measurement (DOT-HTN) in uncontrolled hypertensive patients - Effect on blood pressure, safety and patient perception.
Conclusions: Two of eight patients seemed to be non-adherent after DOT-HTN. Descriptive findings suggested reluctance towards control with DOT-HTN not captured by the VAS assessment. No DOT-related medical adverse-effects were reported. PMID: 31250668 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - June 30, 2019 Category: Hematology Tags: Blood Press Source Type: research

Medication persistence to antihypertensive drug treatment - a cross-sectional study of attitudes towards hypertension and medication in persistent and non-persistent patients.
Authors: Qvarnström M, Kahan T, Kieler H, Brandt L, Hasselström J, Wettermark B Abstract Purpose: To study the differences in attitudes towards hypertension and drug treatment between patients persistent and non-persistent to antihypertensive drug treatment. Materials and methods: Cross-sectional study on patients with hypertension treated at 25 primary healthcare centres in Stockholm, Sweden. Questionnaires were sent to the patients 3-12 months after initiation of antihypertensive drug treatment. Persistent medication users, defined as patients with less than 30 days without tablet supply between prescri...
Source: Blood Pressure - June 19, 2019 Category: Hematology Tags: Blood Press Source Type: research

The PARAGON Heart Failure trial - ongoing investigation of the angiotensin receptor antagonist/neprilysin inhibitor sacubitril/valsartan in heart failure patients with hypertension and preserved ejection fraction.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31184508 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - June 13, 2019 Category: Hematology Tags: Blood Press Source Type: research

Non-dipping blood pressure pattern and new-onset diabetes in a 21-year follow-up.
Authors: Lempiäinen PA, Vasunta RL, Bloigu R, Kesäniemi YA, Ukkola OH Abstract PURPOSE: Non-dipping blood pressure (BP) pattern has been associated with metabolic changes and cardiovascular events. With regard of diabetes, studies are scarce. Our aim was to investigate if there is an association between changes in dipping patterns and incidence of diabetes. MATERIALS AND METHODS: A 24-h ambulatory BP measurement was recorded in addition to other laboratory measurements, and a questionnaire and physical examination were carried out in the baseline study and after 21-year follow-up among a study populat...
Source: Blood Pressure - May 17, 2019 Category: Hematology Tags: Blood Press Source Type: research

Central hemodynamics in relation to blood lead in young men prior to chronic occupational exposure.
CONCLUSION: At the exposure levels observed in our current study, aPWV, the gold standard to assess arterial stiffness, was not associated with BL. Increased peripheral arterial resistance, as reflected by higher diastolic pressure, might bring reflection points closer to the heart, thereby moving the backward wave into systole and increasing the augmentation ratio in relation to BL. PMID: 31075995 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 13, 2019 Category: Hematology Tags: Blood Press Source Type: research

Need for multiple risk reduction strategies in clinical trials enrolling high risk patients - FOURIER investigating PCSK-9 inhibitor to lower cholesterol revisited.
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 31076016 [PubMed - in process] (Source: Blood Pressure)
Source: Blood Pressure - May 13, 2019 Category: Hematology Tags: Blood Press Source Type: research

Prognostic impact of increased pulse pressure/stroke index in a registry of hypertensive patients: the Campania Salute Network.
Authors: Mancusi C, Losi MA, Izzo R, Gerdts E, Canciello G, Arnone MI, Trimarco B, de Simone G, De Luca N Abstract OBJECTIVES: Increased arterial stiffness is associated with advanced arteriosclerosis, abnormal left ventricular (LV) geometry and function. Whether increased arterial stiffness is associated with incident cardiovascular (CV) event (MACE), independent of other markers of target organ damage needs to be clarified. METHODS: We selected hypertensive participants of the Campania Salute Network free of prevalent CV disease, with available echocardiogram and carotid ultrasound, ejection fraction ≥50%,...
Source: Blood Pressure - May 10, 2019 Category: Hematology Tags: Blood Press Source Type: research

A randomized cross-over study on the blood pressure lowering effect of the combined passive head-up and -down movement with Device-Guided slow breathing.
CONCLUSIONS: The combined head movement with slow breathing did not influence 24-h BP, but reduced nighttime BP in untreated mild hypertension or high-normal BP. PMID: 31068018 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - May 10, 2019 Category: Hematology Tags: Blood Press Source Type: research

Removing the mask on hypertension (REMAH) study: Design; quality of blood pressure phenotypes and characteristics of the first 490 participants.
Authors: Nwakile PC, Chori BS, Danladi B, Umar A, Okoye IC, Nwegbu M, Zawaya K, Essien I, Sada K, Ogedengbe J, Aje A, Isiguzo G, Odili AN Abstract PURPOSE: Previous studies that evaluated the prevalence of hypertension in Nigeria were either clinic based, non-standardized or did not include out-of-clinic blood pressure (BP) measurement. MATERIALS AND METHODS: We selected a rural and an urban community in one state in each of the 6 geopolitical zones of Nigeria. Five consecutive BP of adults older than 18 years were measured in the clinic following which, each participant was provided with a home BP device to ob...
Source: Blood Pressure - May 9, 2019 Category: Hematology Tags: Blood Press Source Type: research

Short-term reproducibility of the 24-h ambulatory monitoring of brachial and central hemodynamics in untreated Chinese.
Authors: Wang Y, Zhang DY, Guo QH, Cheng YB, Huang QF, Sheng CS, Xu TY, Wang JG, Li Y Abstract OBJECTIVE: Advanced technology allows non-invasive monitoring of the 24-h brachial and central hemodynamics simultaneously. However, related reproducibility data was limited in White patients. We therefore explored if the novel measurements would be reproducible in Chinese. METHODS: From February 2017 to January 2018, 152 untreated patients who were suspected of hypertension and referred for ambulatory blood pressure (BP) monitoring were recruited. Ambulatory BP monitoring was repeated within one month (median, 12.5 d...
Source: Blood Pressure - May 7, 2019 Category: Hematology Tags: Blood Press Source Type: research

Genome-wide association study of white-coat effect in hypertensive patients.
Authors: Rimpelä JM, Niiranen T, Jula A, Pörsti IH, Tikkakoski A, Havulinna A, Lehtimäki T, Salomaa V, Kontula KK, Hiltunen TP Abstract BACKGROUND: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role. METHODS: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension...
Source: Blood Pressure - May 4, 2019 Category: Hematology Tags: Blood Press Source Type: research

Cardiovascular reactivity and oxidative stress in young and older adults: the African-PREDICT and SABPA studies.
CONCLUSIONS: In the older black group, cardiovascular reactivity associated with markers of glutathione metabolism, suggesting a possible compensatory up-regulation thereof in order to correct their heightened responses to stress. Independent of age, findings in the white groups support a regulatory role of ROS to maintain vascular tone during stress. PMID: 31030564 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - April 30, 2019 Category: Hematology Tags: Blood Press Source Type: research

Clinical inertia in hypertension: a new holistic and practical concept within the cardiovascular continuum and clinical care process.
CONCLUSION: Although some concepts should be considered as 'justified inertia' or 'investigator inertia', the idea that inertia may be present throughout the continuum of care gives physicians a holistic view of the problem that is easily applicable to their clinical practice. Measures to overcome inertia are complicated because of the intrinsic complexity of the concept. PMID: 31023106 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - April 27, 2019 Category: Hematology Tags: Blood Press Source Type: research

Frequency of fragmented QRS in patients with hypertension.
Authors: Tanriverdi Z, Besli F, Gungoren F, Begenc Tascanov M, Halil Altiparmak I PMID: 31010338 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - April 24, 2019 Category: Hematology Tags: Blood Press Source Type: research

Orthostatic hypotension: definition, classification and evaluation.
CONCLUSIONS: Correct assessment of OH is essential for its accurate diagnosis. The methodology of OH evaluation has not been sufficiently standardized. We emphasize the clinical importance of the uniform investigation of OH, according to the current guidelines for OH definition and meaning. PMID: 30982364 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - April 17, 2019 Category: Hematology Tags: Blood Press Source Type: research

Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study.
CONCLUSIONS: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time. PMID: 30942111 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - April 4, 2019 Category: Hematology Tags: Blood Press Source Type: research

Comparison of arterial stiffness indices measured by pulse wave velocity and pulse wave analysis.
Authors: Zhu H, Gao Y, Cheng H, Lu Y, Cheang I, Xu D, Yao W, Xu T, Zhou F, Zhou Y, Xu F, Kong X, Li X, Zhang H Abstract OBJECTIVE: Arterial stiffness indices measured by pulse wave velocity and pulse wave analysis have been widely studied in different populations. Only a few small studies have been reported regarding these two measurement methods. Therefore, the aim of our study was to compare the arterial stiffness indices measured by pulse wave velocity and pulse wave analysis in a randomly selected Chinese population. METHODS: A total of 4285 subjects were recruited from Gaoyou County, Jiangsu Province, Chin...
Source: Blood Pressure - March 31, 2019 Category: Hematology Tags: Blood Press Source Type: research

Multivariate analysis of hypertension in general US adults based on the 2017 ACC/AHA guideline: data from the national health and nutrition examination survey 1999 to 2016.
Authors: Wang D, Hatahet M, Wang Y, Liang H, Bazikian Y, Bray CL Abstract PURPOSE: Since the publication of the 2017 ACC/AHA hypertension guideline, few studies have analyzed the epidemiology and management of hypertension across many heterogeneous subgroups in the US. MATERIALS AND METHODS: We analyzed the data collected by the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. Participants greater than 20 years of age, who had valid blood pressure measurements, were included in the study. A comprehensive analysis of 14 population subgroups was done to systematically examine how hyper...
Source: Blood Pressure - March 23, 2019 Category: Hematology Tags: Blood Press Source Type: research

Should we calculate arterial stiffness gradient in middle-aged women with increased cardiovascular risk?
Authors: Laucyte-Cibulskiene A, Vickiene A, Ryliskyte L, Badariene J, Rimsevicius L, Miglinas M Abstract PURPOSE: The study was designed to evaluate clinical and laboratory determinants pulse wave velocity (PWV) ratio in women at the age of 50-65 years without overt cardiovascular disease but having elevated cardiovascular risk, such as hypertension, obesity, diabetes and hypercholesterolemia. MATERIALS AND METHODS: We analyzed data from 1170 women enrolled in the national-wide primary prevention program. Univariate and multivariate linear regression analysis was used to establish independent risk factors in gr...
Source: Blood Pressure - March 20, 2019 Category: Hematology Tags: Blood Press Source Type: research

Association between functional capacity and heart rate variability in patients with uncomplicated type 2 diabetes.
Authors: Vukomanovic V, Suzic-Lazic J, Celic V, Cuspidi C, Petrovic T, Ilic S, Skokic D, Armando Morris D, Tadic M Abstract OBJECTIVE: We sought to investigate functional capacity, heart rate variability (HRV), as well as their relationship in the patients with uncomplicated type 2 diabetes. METHODS: This cross-sectional observational study included 62 controls and 53 uncomplicated diabetic patients. Included subjects underwent laboratory analysis, 24-h ECG Holter monitoring and cardiopulmonary exercise testing. RESULTS: All parameters of time and frequency domain of HRV were decreased in the diabetic patie...
Source: Blood Pressure - March 8, 2019 Category: Hematology Tags: Blood Press Source Type: research

A sleep apnoea questionnaire predicts organ damage in hypertensive patients.
Authors: Bisogni V, Pengo MF, Maiolino G, Cesari M, Lerco S, Rossitto G, Concistrè A, Petramala L, Letizia C, Seccia TM, Rossi GP Abstract BACKGROUND: Arterial hypertension is associated with obstructive sleep apnoea, poor quality and duration of sleep, which might contribute to hypertension-mediated organ damage. METHODS: We investigated the presence of insomnia, restless legs syndrome, and obstructive sleep apnoea using validated questionnaires (Insomnia Severity Index, Restless Legs Syndrome Rating Scale, and STOP-Bang), and their relationship with hypertension-mediated organ damage, in hypertensive p...
Source: Blood Pressure - March 8, 2019 Category: Hematology Tags: Blood Press Source Type: research

Atherogenic index of plasma is related to arterial stiffness but not to blood pressure in normotensive and never-treated hypertensive subjects.
Authors: Choudhary MK, Eräranta A, Koskela J, Tikkakoski AJ, Nevalainen PI, Kähönen M, Mustonen J, Pörsti I Abstract BACKGROUND AND AIMS: Atherogenic index of plasma (AIP), defined as the logarithm of triglycerides to high-density lipoprotein cholesterol (HDL-C) ratio, is a strong predictor of future cardiovascular disease. Our aim was to examine the association of AIP with haemodynamic variables in normotensive and never-treated hypertensive subjects in a cross-sectional study. METHODS: Supine haemodynamics in 615 subjects without antihypertensive and lipid-lowering medications were examine...
Source: Blood Pressure - March 4, 2019 Category: Hematology Tags: Blood Press Source Type: research

Will we ever use angiotensin receptor neprilysin inhibition (ARNi) for the treatment of hypertension?
Authors: Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S PMID: 30806086 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - February 28, 2019 Category: Hematology Tags: Blood Press Source Type: research

New data on antihypertensive drugs and risk of cancer: should we worry?
Authors: Burnier M, Narkiewicz K, Kjeldsen SE, Oparil S PMID: 30714837 [PubMed - in process] (Source: Blood Pressure)
Source: Blood Pressure - February 5, 2019 Category: Hematology Tags: Blood Press Source Type: research

Association of aortic stiffness, carotid intima-media thickness and endothelial function with cardiovascular events in metabolic syndrome subjects.
The objective of this study was to assess predictive value of various arterial markers for cardiovascular (CV) events in patients with metabolic syndrome (MetS). MATERIALS AND METHODS: A longitudinal study with the follow-up period of 3.9 ± 1.7 years investigated 2728 middle-aged (53.9 ± 6.2 years old, 63% women) MetS subjects without overt CV disease. The study cohort was comprised of the participants of the Lithuanian High Cardiovascular Risk primary prevention program. The baseline assessment included the evaluation of brachial flow-mediated dilatation (FMD), carotid intima-...
Source: Blood Pressure - February 1, 2019 Category: Hematology Tags: Blood Press Source Type: research

Association of left bundle branch block with new onset abnormal wall motion in treated hypertensive patients with left ventricle hypertrophy: the LIFE Echo Sub-study.
Authors: Stokke IM, Li ZB, Cicala S, Okin PM, Kjeldsen SE, Devereux RB, Wachtell K Abstract AIMS: We aimed to investigate whether left bundle branch block (LBBB) is related to new-onset left ventricle (LV) wall motion abnormalities during treatment in hypertensive patients with electrocardiographic (ECG) defined left ventricular hypertrophy (LVH). METHODS AND RESULTS: 960 patients with essential hypertension and ECG-LVH participating in the LIFE Echo Sub-study were investigated at baseline and annually with echocardiography, during randomized antihypertensive therapy. After excluding patients with LV wall motio...
Source: Blood Pressure - February 1, 2019 Category: Hematology Tags: Blood Press Source Type: research

Prevalence and risk factors for hypertensive crisis in a predominantly African American inner-city community.
Authors: Waldron FA, Benenson I, Jones-Dillon SA, Zinzuwadia SN, Adeboye AM, Eris E, Mbadugha NE, Vicente N, Over A Abstract PURPOSE: A 3-year case control study was conducted to determine the prevalence of hypertensive crisis and its subtypes, hypertensive emergency and hypertensive urgency. The secondary objectives were to identify risk factors for hypertensive emergencies and to determine the odds of developing acute target organ damage among predominantly African American patients with a confirmed diagnosis of hypertension. MATERIALS AND METHODS: Using emergency department medical records, patients with a c...
Source: Blood Pressure - January 25, 2019 Category: Hematology Tags: Blood Press Source Type: research

Association between fragmented QRS and exercise intolerance in hypertensive patients: the relation with coronary flow.
Authors: Mahfouz RA, Gouda M, Ghareb MS, Galal I Abstract OBJECTIVE: We aimed to investigate the relation between the presence of fragmented QRS (FQRS) and exercise intolerance as assessed by 6 minute walking test (6MWT) and its association with coronary flow reserve (CFR). METHODS: One hundred and twenty patients with hypertension (age: 47.3 + 6.9) who were never treated and without left ventricular hypertrophy underwent 6MWT. Echocardiographic examination was obtained for all patients. CFR was calculated as the hyperemic to baseline mean velocity ratio (hyperemia was induced by intravenou...
Source: Blood Pressure - January 25, 2019 Category: Hematology Tags: Blood Press Source Type: research